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https://www.readbyqxmd.com/read/28931039/abnormalities-in-substance-p-neurokinin-1-receptor-binding-in-key-brainstem-nuclei-in-sudden-infant-death-syndrome-related-to-prematurity-and-sex
#1
Fiona M Bright, Robert Vink, Roger W Byard, Jhodie R Duncan, Henry F Krous, David S Paterson
Sudden infant death syndrome (SIDS) involves failure of arousal to potentially life threatening events, including hypoxia, during sleep. While neuronal dysfunction and abnormalities in neurotransmitter systems within the medulla oblongata have been implicated, the specific pathways associated with autonomic and cardiorespiratory failure are unknown. The neuropeptide substance P (SP) and its tachykinin neurokinin-1 receptor (NK1R) have been shown to play an integral role in the modulation of homeostatic function in the medulla, including regulation of respiratory rhythm generation, integration of cardiovascular control, and modulation of the baroreceptor reflex and mediation of the chemoreceptor reflex in response to hypoxia...
2017: PloS One
https://www.readbyqxmd.com/read/28928913/quality-of-life-in-elderly-iranian-population-using-leiden-padua-questionnaire-a-systematic-review-and-meta-analysis
#2
REVIEW
Parvin Cheraghi, Zahra Cheraghi, Amin Doosti-Irani, Sima Nedjat, Saharnaz Nedjat
The world population is getting old rapidly; the aging population is the new phenomenon in Iran too. The aim of this meta-analysis was to estimate the overall and subscales mean score of quality of life (QOL) based on the Leiden-Padua (LEIPAD) questionnaire among the elderly population of Iran. The major international and national databases including; Medlin, Scopus, Science Direct, SID, MagIran, IranMedex, and Irandoc was searched. All cross-sectional studies, which measured the QOL among the elderly population in Iran using the LEIPAD questionnaire, were included...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28926779/cardiopulmonary-resuscitation-associated-injuries-in-still-newborns-infants-and-toddlers-in-a-german-forensic-collective
#3
B Ondruschka, C Baier, M Siekmeyer, C Buschmann, J Dreßler, M Bernhard
INTRODUCTION: Cardiopulmonary resuscitation (CPR) may lead to injuries. Forensic experts are sometimes confronted with claims that fatal injuries were caused by chest compressions during CPR rather than by assaults. We want to answer, how often CPR-associated injuries are present in younger children and if they may mimic injuries caused by abuse. MATERIAL AND METHODS: All autopsy records of the Institute of Legal Medicine in Leipzig, Germany in a 6-year study period were used (2011-2016)...
September 12, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28922849/medullary-serotonin-neuron-abnormalities-in-an-australian-cohort-of-sudden-infant-death-syndrome
#4
Fiona M Bright, Roger W Byard, Robert Vink, David S Paterson
Serotonin (5-hydroxytryptamine [5-HT]) neurons in the medulla oblongata project extensively to key autonomic and respiratory nuclei in the brainstem and spinal cord regulating critical homeostatic functions. Multiple abnormalities in markers of 5-HT function in the medulla in sudden infant death syndrome (SIDS) have been reported, informing the hypothesis that at least a subset of SIDS cases is caused by deficits in 5-HT function resulting in impaired homeostatic responses to potentially life-threatening events during sleep...
October 1, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/28920784/treatment-success-in-three-andean-bears-tremarctos-ornatus-with-alopecia-syndrome-using-oclacitinib-maleate-apoquel%C3%A2
#5
Gabby J Drake, Tim Nuttall, Javier López, William Magnone, Antoine Leclerc, Romain Potier, Alexis Lécu, Maëlle Guézénec, Lydia Kolter, Amélie Nicolau, Karin Lemberger, Didier Pin, Sallie B Cosgrove
Andean bear (Tremarctos ornatus) alopecia syndrome (ABAS) commonly affects captive bears, particularly sexually mature females. ABAS is characterized by bilaterally symmetrical predominantly flank alopecia with or without profound pruritus and secondary bacterial and Malassezia infections. There is no effective treatment and severely affected bears have been euthanized. This paper describes the successful management of ABAS in three female Andean bears. Skin biopsies and cytology revealed a mixed dermal inflammatory infiltrate, alopecia, hyperkeratosis, and Malassezia dermatitis...
September 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28916264/sidt2-transports-extracellular-dsrna-into-the-cytoplasm-for-innate-immune-recognition
#6
Tan A Nguyen, Blake R C Smith, Michelle D Tate, Gabrielle T Belz, Marilou H Barrios, Kirstin D Elgass, Alexandra S Weisman, Paul J Baker, Simon P Preston, Lachlan Whitehead, Alexandra Garnham, Rachel J Lundie, Gordon K Smyth, Marc Pellegrini, Meredith O'Keeffe, Ian P Wicks, Seth L Masters, Craig P Hunter, Ken C Pang
Double-stranded RNA (dsRNA) is a common by-product of viral infections and acts as a potent trigger of antiviral immunity. In the nematode C. elegans, sid-1 encodes a dsRNA transporter that is highly conserved throughout animal evolution, but the physiological role of SID-1 and its orthologs remains unclear. Here, we show that the mammalian SID-1 ortholog, SIDT2, is required to transport internalized extracellular dsRNA from endocytic compartments into the cytoplasm for immune activation. Sidt2-deficient mice exposed to extracellular dsRNA, encephalomyocarditis virus (EMCV), and herpes simplex virus 1 (HSV-1) show impaired production of antiviral cytokines and-in the case of EMCV and HSV-1-reduced survival...
September 7, 2017: Immunity
https://www.readbyqxmd.com/read/28912666/prevalence-of-low-back-pain-in-iranian-nurses-a-systematic-review-and-meta-analysis
#7
Yosra Azizpour, Ali Delpisheh, Zahra Montazeri, Kourosh Sayehmiri
BACKGROUND: Low back pain (LBP) as a musculoskeletal disorder is one of the most common occupational injuries in nurses but there isn't any valid measure of the prevalence of LBP in Iranian nursing. In order to increase the power and improve the estimates of the prevalence of LBP in Iranian nurses, a comprehensive meta-analysis was carried out. A summary measure of all studies conducted in this field was found and distributions of LBP were evaluated based on different variables. METHODS: Inclusion criteria included articles with prevalence of LBP in Iranian nurses, who had at least six months of work experience without any trauma, injuries to spine, or any underlying disease...
2017: BMC Nursing
https://www.readbyqxmd.com/read/28904535/effect-of-massage-therapy-on-labor-pain-reduction-in-primiparous-women-a-systematic-review-and-meta-analysis-of-randomized-controlled-clinical-trials-in-iran
#8
REVIEW
Mehdi Ranjbaran, Maahboobeh Khorsandi, Pegah Matourypour, Mohsen Shamsi
BACKGROUND: Pain is a common experience for women during labor. Therefore, pain relief care for mothers during labor is very important. This meta-analysis was conducted to evaluate the efficacy of massage therapy on labor pain reduction in primiparous women. MATERIALS AND METHODS: In this meta-analysis, the databases of Web of Knowledge, PubMed, Scopus, Cochrane, Iranmedex, Scientific Information Database (SID), and Magiran were searched for published articles in English and Persian language up to January 2016...
July 2017: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/28900448/scolicidal-agents-for-protoscolices-of-echinococcus-granulosus-hydatid-cyst-review-of-literature
#9
REVIEW
Seyedeh Maryam Sharafi, Raheleh Rafiei Sefiddashti, Behnam Sanei, Morteza Yousefi, Hossein Yousofi Darani
Hydatid cyst is the larval stage of dog tape worm Echinococcus granulosus. Protoscolices are parasite larvae that develop into adult worms in the final host intestine. During surgical treatment of human hydatidsosis spillage of live protoscolices is the major cause of hydatidosis recurrence. To prevent this problem scolicidal agent such as hypertonic salt are used to kill the protoscolices that may disseminate into the patient's tissues during surgery. However, they may have some unacceptable side effects. To find scolicidal agents with high efficacy, the effect of different compounds on protoscolices of hydatid cyst in vitro has been reviewed...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28894537/lifestyles-in-suburban-populations-a-systematic-review
#10
REVIEW
Samira Khayat, Mahrokh Dolatian, Ali Navidian, Zohreh Mahmoodi, Nasibeh Sharifi, Amir Kasaeian
BACKGROUND: Lifestyle and suburban population are important issues in the field of health. The living conditions of informal settlements can lead to acquisition of an unhealthy lifestyle. OBJECTIVE: This study has been designed to investigate the articles that have been published regarding lifestyle in suburban populations. METHODS: The present research was a systematic review of studies in databases including Iranmedex, Magiran, SID, Irandoc, PubMed, Google Scholar, Science Direct and Scopus, in 2017...
July 2017: Electronic Physician
https://www.readbyqxmd.com/read/28881142/thermal-and-cytokine-responses-to-endotoxin-challenge-during-early-life
#11
Fiona Brigid McDonald, Ahmad M Khawaja, Ahmad Ali Imran, Margot E Ellis, Kumaran Chandrasekharan, Shabih U Hasan
Sudden infant death syndrome (SIDS) remains the leading cause of infant mortality beyond the neonatal period. An increase in body temperature as a result of high environmental temperature, over-wrapping of infants and/or infection are associated with SIDS. Endotoxins such as lipopolysaccharide (LPS) and heat stress may perturb cardiorespiratory function and thermoregulation. Although LPS-mediated body temperature and cytokine responses are well-documented in older animals, the capacity of LPS to induce fever and cytokine response in young rats remains unclear...
September 7, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28880023/sudden-infant-death-syndrome-and-inherited-cardiac-conditions
#12
REVIEW
Alban-Elouen Baruteau, David J Tester, Jamie D Kapplinger, Michael J Ackerman, Elijah R Behr
Sudden infant death syndrome (SIDS) is the leading cause of post-neonatal infant mortality in developed countries, characterized by the death of infants for no obvious reason and without prior warning. The complex interaction of multiple factors in the pathogenesis of SIDS is illustrated by the 'triple risk hypothesis', which proposed that SIDS results from a convergence of three overlapping risk factors: a critical developmental period, an exogenous stressor, and underlying genetic and/or nongenetic vulnerability in the infant...
September 7, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28877228/exploring-the-possible-relationship-between-ambient-heat-and-sudden-infant-death-with-data-from-vienna-austria
#13
Thomas Waldhoer, Harald Heinzl
A non-linear relationship between maximum ambient temperature and number of sudden infant death syndrome (SIDS) cases had been reported for Montreal, Canada, for the warm season. In particular, high maximum ambient temperatures were found to be extra-hazardous for infants. The study was replicated with data from Vienna, Austria, applying the same statistical approach. Vienna is roughly comparable to Montreal with regard to temperatures in the warm season, size of population, and number of SIDS cases. Although the Viennese study was powerful enough to detect even smaller effects, the Montrealean results could not be confirmed...
2017: PloS One
https://www.readbyqxmd.com/read/28874467/an-evolutionarily-conserved-pathway-essential-for-orsay-virus-infection-of-caenorhabditis-elegans
#14
Hongbing Jiang, Kevin Chen, Luis E Sandoval, Christian Leung, David Wang
Many fundamental biological discoveries have been made in Caenorhabditis elegans The discovery of Orsay virus has enabled studies of host-virus interactions in this model organism. To identify host factors critical for Orsay virus infection, we designed a forward genetic screen that utilizes a virally induced green fluorescent protein (GFP) reporter. Following chemical mutagenesis, two Viro (virus induced reporter off) mutants that failed to express GFP were mapped to sid-3, a nonreceptor tyrosine kinase, and B0280...
September 5, 2017: MBio
https://www.readbyqxmd.com/read/28874466/an-alternative-stat-signaling-pathway-acts-in-viral-immunity-in-caenorhabditis-elegans
#15
Mélanie Tanguy, Louise Véron, Przemyslaw Stempor, Julie Ahringer, Peter Sarkies, Eric A Miska
Across metazoans, innate immunity is vital in defending organisms against viral infection. In mammals, antiviral innate immunity is orchestrated by interferon signaling, activating the STAT transcription factors downstream of the JAK kinases to induce expression of antiviral effector genes. In the nematode Caenorhabditis elegans, which lacks the interferon system, the major antiviral response so far described is RNA interference (RNAi), but whether additional gene expression responses are employed is not known...
September 5, 2017: MBio
https://www.readbyqxmd.com/read/28869119/does-home-based-pulmonary-rehabilitation-improve-functional-capacity-peripheral-muscle-strength-and-quality-of-life-in-patients-with-bronchiectasis-compared-to-standard-care
#16
Anderson José, Anne E Holland, Cristiane S de Oliveira, Jessyca P R Selman, Rejane A S de Castro, Rodrigo A Athanazio, Samia Z Rached, Alberto Cukier, Rafael Stelmach, Simone Dal Corso
BACKGROUND: Home-based pulmonary rehabilitation is a promising intervention that may help patients to overcome the barriers to undergoing pulmonary rehabilitation. However, home-based pulmonary rehabilitation has not yet been investigated in patients with bronchiectasis. OBJECTIVES: To investigate the effects of home-based pulmonary rehabilitation in patients with bronchiectasis. METHODS: An open-label, randomized controlled trial with 48 adult patients with bronchiectasis will be conducted...
August 19, 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/28863284/establishing-objective-volume-outcome-measures-for-anterior-and-posterior-cervical-spine-fusion
#17
Micah B Blais, Sean Michael Rider, Daniel J Sturgeon, Justin Blucher, Jay M Zampini, James D Kang, Andrew J Schoenfeld
OBJECTIVES: There is a growing literature on the relationship between provider volume and patient outcomes, specifically within joint arthroplasty and lumbar spine surgery. Such benchmarks have yet to be established for many other spinal procedures, including cervical fusion. We sought to determine whether outcomes-based volume measures for both surgeons and hospitals can be established for cervical spine fusion procedures. PATIENTS AND METHODS: This was a retrospective review of patient data in the Florida Statewide Inpatient Dataset (SID; 2011-14)...
August 24, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28861355/prevalence-of-retinopathy-of-prematurity-in-iran-a-systematic-review-and-meta-analysis
#18
Saman Maroufizadeh, Amir Almasi-Hashiani, Reza Omani Samani, Mahdi Sepidarkish
AIM: To estimate overall prevalence of retinopathy of prematurity (ROP) in Iran using a systematic review and Meta-analysis. METHODS: A systematic review and Meta-analysis was performed of all published studies pertaining to prevalence of ROP using international and national electronic databases (ISI Web of Sciences, PubMed, Scopus, Google Scholar, SID, MagIran, and IranMedex) from their inception until May 2016 with standard keywords. Begg and Egger tests were used to examine the publication bias and Cochran test and I(2) statistics were used to evaluate the statistical heterogeneity...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28854754/effects-of-multi-carbohydrase-and-phytase-on-standardized-ileal-digestibility-of-amino-acids-and-apparent-metabolizable-energy-in-canola-meal-fed-to-broiler-chicks
#19
C Gallardo, J C Dadalt, E Kiarie, M A Trindade Neto
Two assays were conducted to evaluate nutritive value of canola meal (CM) fed to broiler chicks without or with a multi-carbohydrase (MC) preparation (700 U α-galactosidase, 2,200 U galactomannanase, 30,000 U xylanase, and 22,000 U β-glucanase per kg of diet) and phytase (Phy, 500 FTU per kg of diet). Assay 1 determined apparent total tract digestibility (ATTD) of nutrients and metabolizable energy (AME) by the difference method. Assay 2 determined apparent ileal digestibility (AID) and standardized ileal digestibility (SID) of amino acids by the index method...
September 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28853101/the-effect-of-folate-and-folate-plus-zinc-supplementation-on-endocrine-parameters-and-sperm-characteristics-in-sub-fertile-men-a-systematic-review-and-meta-analysis
#20
Morvarid Irani, Malihe Amirian, Ramin Sadeghi, Justine Le Lez, Robab Latifnejad Roudsari
PURPOSE: To evaluate the effect of folate and folate plus zinc supplementation on endocrine parameters and sperm characteristics in sub fertile men. MATERIALS AND METHODS: We conducted a systematic review and meta-analysis. Electronic databases of Medline, Scopus , Google scholar and Persian databases (SID, Iran medex, Magiran, Medlib, Iran doc) were searched from 1966 to December 2016 using a set of relevant keywords including "folate or folic acid AND (infertility, infertile, sterility)"...
August 29, 2017: Urology Journal
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