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https://www.readbyqxmd.com/read/29774558/clinical-outcome-and-comparison-of-three-different-left-ventricular-assist-devices-in-a-high-risk-cohort
#1
Konstantin Zhigalov, Ahmed Mashhour, Marcin Szczechowicz, Sabreen Mkalaluh, Sergei Karagezian, Irakli Gogia, Maxim Isaev, Bakitbek K Kadyraliev, Jerry Easo, Juergen Ennker, Harald C Eichstaedt, Alexander Weymann
We present a comparison between three left ventricular assist devices (LVADs): HeartWare (HVAD) (HeartWare International Inc., Framingham, MA, USA), HeartMate II (HMII) and HeartMate III (HMIII) (Thoratec Corp., Pleasanton, CA, USA). To our knowledge, no study to date has aimed at placing these three devices in juxtaposition. Between June 2007 and June 2017, 108 consecutive patients received HMII, n = 77 (71.3%), HVAD, n = 14 (13%), or HM III, n = 17 (15.7%), for end-stage heart failure. Mean age was 63...
May 17, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29766321/acute-kidney-injury-after-implantation-of-a-left-ventricular-assist-device-a-comparison-of-axial-flow-heartmate-ii-and-centrifugal-flow-heartware-hvad-devices
#2
Azeen Anjum, Chitaru Kurihara, Andre Critsinelis, Masashi Kawabori, Tadahisa Sugiura, Andrew B Civitello, Whitson B Etheridge, Reynolds M Delgado, Leo Simpson, Joggy K George, Ajith P Nair, O H Frazier, Jeffrey A Morgan
Continuous-flow left ventricular assist devices (CF-LVADs) are increasingly being used to treat advanced, refractory chronic heart failure. Herein, we sought to determine the incidence of postoperative acute kidney injury (AKI) in axial-flow (HeartMate II; HM-II) and centrifugal-flow (HVAD) CF-LVAD recipients, as well as the effect of AKI on mortality. The study cohort comprised 520 patients who received a HM-II (n = 398) or HVAD (n = 122) at our center between November 2003 and March 2016. Their records were reviewed to determine the incidence of RIFLE-defined AKI after LVAD implantation...
May 15, 2018: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/29759673/characterization-of-ventricular-tachycardia-after-left-ventricular-assist-device-implantation-as-destination-therapy-a-single-center-ablation-experience
#3
Joshua D Moss, Erin E Flatley, Andrew D Beaser, John H Shin, Hemal M Nayak, Gaurav A Upadhyay, Martin C Burke, Valluvan Jeevanandam, Nir Uriel, Roderick Tung
OBJECTIVES: This study sought to report mechanisms of ventricular tachycardia (VT) and outcomes of VT ablation in patients with a left ventricular assist device (LVAD) as destination therapy. BACKGROUND: Continuous flow LVAD implantation plays a growing role in the management of end-stage heart failure, and VT is common. There are limited reports of VT ablation in patients with a destination LVAD. METHODS: Patients with a continuous-flow LVAD referred for VT ablation from 2010 to 2016 were analyzed retrospectively...
December 11, 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29757760/cannula-tip-with-integrated-volume-sensor-for-rotary-blood-pump-control-early-stage-development
#4
Joshua Cysyk, Ray Newswanger, Eric Popjes, Walter Pae, Choon-Sik Jhun, Jenelle Izer, William Weiss, Gerson Rosenberg
The lack of direct measurement of left ventricular unloading is a significant impediment to the development of an automatic speed control system for continuous-flow left ventricular assist devices (cf-LVADs). We have developed an inlet cannula tip for cf-LVADs with integrated electrodes for volume sensing based on conductance. Four platinum-iridium ring electrodes were installed into grooves on a cannula body constructed from polyetheretherketone (PEEK). A sinusoidal current excitation waveform (250 μA pk-pk, 50 kHz) was applied across one pair of electrodes, and the conductance-dependent voltage was sensed across the second pair of electrodes...
May 10, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29734258/red-cell-distribution-width-predicts-90-day-mortality-in-continuous-flow-left-ventricular-assist-device-patients
#5
Lauren K Truby, Lakshmi Sridharan, Raul J Flores, A Reshad Garan, Douglas Jennings, Melana Yuzefpolskaya, Koji Takeda, Hiroo Takayama, Yoshifumi Naka, Paolo C Colombo, Veli K Topkara
Red cell distribution width (RDW) measures the variance in size of circulating red blood cells and is a strong independent predictor of morbidity and mortality in cardiovascular disease and heart failure. Predictive power of RDW on mortality after continuous-flow left ventricular assist device (CF-LVAD) implantation remains largely unknown. Four hundred nine patients who underwent CF-LVAD implantation between April 2004 and December 2015 were retrospectively analyzed. The primary outcome of interest was 90 day mortality after CF-LVAD implantation...
April 19, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29734257/noninvasive-measures-of-pulsatility-and-blood-pressure-during-continuous-flow-left-ventricular-assist-device
#6
Sabarivinoth Rangasamy, Shivank Madan, Omar Saeed, Daniel J Goldstein, Ulrich P Jorde, Abdissa Negassa, Snehal R Patel
The reliability and validity of a palpable pulse and other noninvasive measures of pulsatility in patients on continuous-flow (CF) left ventricular assist device (LVAD) support have not been rigorously evaluated. We prospectively enrolled 23 patients who had CF-LVAD and an arterial catheter for blood pressure (BP) monitoring. Pulse pressure (PP) via the arterial line was compared with three noninvasive measures of pulsatility: presence of a palpable pulse, pulsatility index (PI), and aortic valve opening (AVO)...
April 19, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29731190/novel-driveline-route-for-prevention-from-driveline-infection-triple-tunnel-method
#7
Shuichi Yoshitake, Osamu Kinoshita, Kan Nawata, Yasuhiro Hoshino, Yoshifumi Itoda, Mitsutoshi Kimura, Haruo Yamauchi, Minoru Ono
BACKGROUND: The most prevalent and serious infection related to left ventricular assist devices (LVADs) is driveline infection (DLI). From 2014, we employed a revised surgical technique (triple tunnel method), which deployed a longer subfascial driveline (DL) route. METHODS AND PATIENTS: We retrospectively analyzed 34 patients fitted with either of the two types of axial pumps: HeartMate II (n=23) and Jarvik 2000 (n=11). Prior to 2014, the DL proceeded from the pump pocket just above the posterior sheath of the rectus muscle toward a vertical skin incision at the right lateral border of the rectus muscle...
May 3, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29716730/abracadabra-i-ii%C3%A2-heartmate-3
#8
EDITORIAL
Jay K Bhama
No abstract text is available yet for this article.
March 29, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29715362/characterizing-the-heartmate-ii-left-ventricular-assist-device-outflow-using-particle-image-velocimetry
#9
Grant W Rowlands, Bryan C Good, Steven Deutsch, Keefe B Manning
Ventricular assist devices (VADs) are implanted in patients with a diseased ventricle to maintain peripheral perfusion as a bridge-to-transplant or as destination therapy. However, some patients with continuous flow VADs (e.g., HeartMate II (HMII)) have experienced gastrointestinal (GI) bleeding, in part caused by the proteolytic cleavage or mechanical destruction of von Willebrand factor (vWF), a clotting glycoprotein. in vitro studies were performed to measure the flow located within the HMII outlet cannula under both steady and physiological conditions using particle image velocimetry (PIV)...
July 1, 2018: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29688916/gastrointestinal-bleeding-with-left-ventricular-assist-devices-lvad-locating-the-leak-and-identifying-outcomes
#10
Sarah Malik, Shahbaz A Malik, Laura L Ulmer, Lokesh K Jha, Michael S Strupp, Eugenia Raichlin, Elizabeth R Lyden, Alexander T Hewlett
BACKGROUND AND GOALS: Gastrointestinal bleeding (GIB) is a significant complication following left ventricular assist device (LVAD) implantation. We evaluated the incidence, predictors, endoscopic findings, and outcomes of GIB in LVAD recipients. STUDY: Retrospective review of 205 adult patients undergoing HeartMate II LVAD implantation from January 2012 to June 2016. Patients were reviewed and separated into GIB (n=57; 28%) and non-GIB (n=148; 72%) groups. RESULTS: Median time to GIB was 55 (range, 3 to 730) days...
April 23, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29648627/late-outcomes-of-subcostal-exchange-of-the-heartmate-ii-left-ventricular-assist-device-a-word-of-caution
#11
Sarah N Yu, Hiroo Takayama, Jiho Han, Arthur R Garan, Paul Kurlansky, Melana Yuzefpolskaya, Paolo C Colombo, Yoshifumi Naka, Koji Takeda
OBJECTIVES: Previous studies have shown the usefulness of the subcostal exchange of the HeartMate II left ventricular assist device for device malfunction. However, long-term data are still limited. METHODS: Between March 2004 and July 2017, 41 of 568 (7.2%) patients who had received a HeartMate II implant at our institution had a device exchange via a subcostal incision. We summarized early and late outcomes. RESULTS: Forty-one patients had a total of 48 subcostal pump exchanges...
April 10, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29643259/cerebrovascular-accidents-during-mechanical-circulatory-support-new-predictors-of-ischemic-and-hemorrhagic-strokes-and-outcome
#12
Saef Izzy, Daniel B Rubin, Firas S Ahmed, Feras Akbik, Simone Renault, Katelyn W Sylvester, Henrikas Vaitkevicius, Jennifer A Smallwood, Michael M Givertz, Steven K Feske
BACKGROUND AND PURPOSE: Left ventricular assist devices (LVADs) have emerged as an effective treatment for patients with advanced heart failure refractory to medical therapy. Post-LVAD strokes are an important cause of morbidity and reduced quality of life. Data on risks that distinguish between ischemic and hemorrhagic post-LVAD strokes are limited. The aim of this study was to determine the incidence of post-LVAD ischemic and hemorrhagic strokes, their association with stroke risk factors, and their effect on mortality...
May 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29629921/assessment-of-cardiac-thrombosis-in-patients-with-left-ventricular-assist-device-using-multidetector-cardiac-computed-tomography
#13
Chukwuemeka A Obi, Nicholas Chan, Monica G Rizkalla, John N Makaryus
: A 79-year-old man with nonischemic cardiomyopathy who underwent left ventricular assist device HeartMate II and automated implantable cardioverter defibrillator placement presented with recurrent refractory sustained ventricular tachycardia, elevated lactate dehydrogenase, and low haptoglobin. Echocardiography demonstrated no thrombosis; cardiac computed tomography showed patent inflow and outflow cannulas while detecting an irregularly shaped mass adherent to the left coronary cusp of the aortic valve, suggesting a thrombus...
April 7, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29626453/meld-xi-scoring-system-to-predict-outcomes-in-patients-who-undergo-lvad-implantation
#14
Andre Critsinelis, Chitaru Kurihara, Nastasya Volkovicher, Masashi Kawabori, Tadahisa Sugiura, Marcos Manon, Suwei Wang, Andrew B Civitello, Jeffrey A Morgan
BACKGROUND: The use of continuous flow left ventricular assist devices (CF-LVAD) to treat advanced heart failure is increasing. While risk score such as MELD and the HeartMate II Risk Score require the use of INR, many patients are on anticoagulation prior to CF-LVAD implantation. The aim of this study was to evaluate the ability of the Model of End-Stage Liver Disease-eXcluding INR (MELD-XI) scoring system to predict clinical outcomes in patients with advanced heart failure who undergo CF-LVAD implantation...
April 4, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29577927/influence-of-diabetes-on-outcomes-in-patients-after-left-ventricular-assist-device-implantation
#15
Chinenye O Usoh, Saadia Sherazi, Barbara Szepietowska, Valentina Kutyifa, Scott McNitt, Anna Papernov, Meng Wang, Jeffrey D Alexis
BACKGROUND: Despite previous studies, the mortality risk of diabetic patients post left ventricular assist device (LVAD) implant remains unclear. In addition, the relationship between the degree of glycemic control and long-term mortality risk in LVAD patients with diabetes has not been established. METHODS: Ninety-five non-diabetic and 96 diabetic patients from the University of Rochester Medical Center, who received a HeartMate II continuous-flow LVAD between May 2008 and June 2014 were included in this study...
March 22, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29571237/an-approach-to-treating-a-patient-with-a-heartmate-ii%C3%A2-left-ventricularassist-device-in-a-multiplace-hyperbaric-chamber-a-case-report
#16
D Orwig, C Logue, S Hendriksen, B Westgard, J Walter, M Pullis, T Masters
Introduction: Left-ventricular assist devices (LVAD) are becoming a common therapy for end-stage heart failure. These devicesare not tested for pressurization in a hyperbaricchamber by the manufacturer. In this article, we present an approach to modify the power supply in order to safely treat a patient with an LVAD. Materials and Methods: Our patient had a HeartMateII™ LVAD and presented for hyperbaric oxygen treatments for severe radiation cystitis. In order to modify this patient's equipment to be compliant with NFPA6 safety standards we made several modifications...
January 2018: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/29562808/prospective-analysis-of-bleeding-events-in-left-ventricular-assist-device-patients
#17
Saadia Sherazi, Peter Kouides, Charles Francis, Charles Julian Lowenstein, Majed Refaai, Grace Conley, Brent Alan Johnson, Eugene Muchnik, Susan Lien, Howard Todd Massey, Jeffrey Dean Alexis
BACKGROUND: Bleeding is a major cause of morbidity in patients with continuous flow left ventricular assist devices (LVADs). We sought to identify clinical predictors of bleeding within the first year of LVAD implantation. METHODS: A prospective study was performed on 30 patients with HeartMate II implantation at the University of Rochester Medical Center, Rochester, New York, United States. Blood was collected within 1 week before implantation, and at 1, 3, and 30 ± 10 days after implantation...
March 1, 2018: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29562790/role-of-computed-tomography-angiography-for-heartmate-ii-left-ventricular-assist-device-thrombosis
#18
Sarah N Yu, Jiho Han, Koji Takeda, Jonathan N Ginns, Paul A Kurlansky, Arthur R Garan, Melana Yuzefpolskaya, Veli K Topkara, Paolo C Colombo, Yoshifumi Naka, Hiroo Takayama
INTRODUCTION: Device thrombosis is one of the most devastating complications of HeartMate II left ventricular assist devices. The purpose of this study is to assess the anatomical properties that the inflow and outflow computed tomography angiography provides in assessing for left ventricular assist device thrombosis, as well as their impact on clinical management and postoperative outcomes. METHODS: Between April 2010 and December 2016, 22 patients who received a HeartMate II left ventricular assist device implantation were readmitted for suspected device thrombosis and underwent a computed tomography angiography for workup...
March 1, 2018: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29540471/outcomes-after-continuous-flow-left-ventricular-assist-device-implantation-as-destination-therapy-at-transplant-versus-nontransplant-centers
#19
D Marshall Brinkley, David DeNofrio, Robin Ruthazer, Amanda R Vest, Navin K Kapur, Gregory S Couper, Michael S Kiernan
BACKGROUND: Since Food and Drug Administration's approval of the HeartMate II left ventricular assist device (LVAD) as destination therapy, the number of hospitals offering LVAD therapy has grown rapidly. A rising number are performed at centers without internal transplant programs. We sought to determine whether outcomes after destination therapy LVAD implantation are similar at transplant and nontransplant centers. METHODS AND RESULTS: Adult recipients of a primary, continuous-flow LVAD as destination therapy between January 2012 and March 2014 from the Interagency Registry for Mechanically Assisted Circulatory Support were included...
March 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29538016/noninvasive-blood-pressure-monitor-designed-for-patients-with-heart-failure-supported-with-continuous-flow-left-ventricular-assist-devices
#20
Pavol Sajgalik, Vaclav Kremen, Vratislav Fabian, Simon Maltais, John M Stulak, Sudhir S Kushwaha, Lyle D Joyce, John A Schirger, Bruce D Johnson
The gold standard for noninvasive blood pressure (BP) measurement, the Doppler technique, does not provide systolic blood pressure (SBP) and diastolic blood pressure (DBP) and may limit therapy outcomes. To improve patient care, we tested specifically designed experimental BP (ExpBP) monitor and the Doppler technique by comparing noninvasive measures to the intraarterial (I-A) BP in 31 patients with end-stage heart failure (4 females) 2.6 ± 3.4 days post-LVAD implantation (20 HeartMate II and 11 HeartWare)...
March 13, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
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