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Cutaneous sarcoidosis

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https://www.readbyqxmd.com/read/29456153/differences-between-patients-with-sarcoidosis-with-and-without-joint-involvement-treated-for-fifteen-years-in-a-third-level-hospital
#1
Carolina Muñoz, Mauricio Restrepo-Escobar, Manuel Martínez-Muñoz, Andrés Echeverri, Javier Márquez, Luis Fernando Pinto
INTRODUCTION: Sarcoidosis is a complex disease of unknown etiology, with a variable course and highly different forms of presentation. Our objective was to characterize all our patients with sarcoidosis with emphasis on their clinical presentation and to establish differences between patients with sarcoidosis with and without joint involvement. METHODS: We reviewed the medical records of all patients with a diagnosis of sarcoidosis who were treated at the outpatient or inpatient services of the Pablo Tobón Uribe Hospital in Medellín, Colombia, from January 2002 to April 2017...
February 15, 2018: Reumatología Clinica
https://www.readbyqxmd.com/read/29417028/annular-cutaneous-sarcoidosis-with-systemic-involvement
#2
Ajay Kumar Mishra, Anu Anna George, Dincy Peter
Sarcoidosis is a granulomatous disease involving multiple systems. Cutaneous involvement is present in 25% of patients. A 42-year-old woman presented with itchy skin lesions on her face for 5 years duration. She was found to have annular and discoid plaques with prominent overlying telangiectasia. A biopsy from the plaque was suggestive of sarcoidosis. On further evaluation, she was found to have both pulmonary and ocular involvements. Annular sarcoidosis is a rare variant of cutaneous sarcoidosis. We report this case to highlight this rare variant of sarcoidosis and discuss the various cutaneous manifestations of sarcoidosis...
July 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29377079/incidence-of-diseases-primarily-affecting-the-skin-by-age-group-population-based-epidemiologic-study-in-olmsted-county-minnesota-and-comparison-with-age-specific-incidence-rates-worldwide
#3
REVIEW
Laurel L Wessman, Louise K Andersen, Mark D P Davis
Understanding the effects of age on the epidemiology of diseases primarily affecting the skin is important to the practice of dermatology, both for proper allocation of resources and for optimal patient-centered care. To fully appreciate the effect that age may have on the population-based calculations of incidence of diseases primarily affecting the skin in Olmsted County, Minnesota, and worldwide, we performed a review of all relevant Rochester Epidemiology Project-published data and compared them to similar reports in the worldwide English literature...
January 29, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29371378/phenotypes-of-organ-involvement-in-sarcoidosis
#4
Jonas Christian Schupp, Sandra Freitag-Wolf, Elena Bargagli, Violeta Mihailović-Vučinić, Paola Rottoli, Aleksandar Grubanovic, Annegret Müller, Arne Jochens, Lukas Tittmann, Jasmin Schnerch, Carmela Olivieri, Annegret Fischer, Dragana Jovanovic, Snežana Filipovic, Jelica Videnovic-Ivanovic, Paul Bresser, René Jonkers, Kate O'Reilly, Ling-Pei Ho, Karoline I Gaede, Peter Zabel, Anna Dubaniewicz, Ben Marshall, Robert Kieszko, Janusz Milanowski, Andreas Günther, Anette Weihrich, Martin Petrek, Vitezslav Kolek, Michael P Keane, Sarah O'Beirne, Seamas Donnelly, Sigridur Olina Haraldsdottir, Kristin B Jorundsdottir, Ulrich Costabel, Francesco Bonella, Benoît Wallaert, Christian Grah, Tatjana Peroš-Golubičić, Mauritio Luisetti, Zamir Kadija, Stefan Pabst, Christian Grohé, János Strausz, Martina Vašáková, Martina Sterclova, Ann Millar, Jiří Homolka, Alena Slováková, Yvonne Kendrick, Anjali Crawshaw, Wim Wuyts, Lisa Spencer, Michael Pfeifer, Dominique Valeyre, Venerino Poletti, Hubertus Wirtz, Antje Prasse, Stefan Schreiber, Michael Krawczak, Joachim Müller-Quernheim
Sarcoidosis is a highly variable, systemic granulomatous disease of hitherto unknown aetiology. The GenPhenReSa (Genotype-Phenotype Relationship in Sarcoidosis) project represents a European multicentre study to investigate the influence of genotype on disease phenotypes in sarcoidosis.The baseline phenotype module of GenPhenReSa comprised 2163 Caucasian patients with sarcoidosis who were phenotyped at 31 study centres according to a standardised protocol.From this module, we found that patients with acute onset were mainly female, young and of Scadding type I or II...
January 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29352388/cutaneous-granulomatosis-a-comprehensive-review
#5
REVIEW
Benedetta Terziroli Beretta-Piccoli, Carlo Mainetti, Marie-Astrid Peeters, Emmanuel Laffitte
Cutaneous granulomatosis is a heterogeneous group of diseases, characterized by a skin inflammatory reaction triggered by a wide variety of stimuli, including infections, foreign bodies, malignancy, metabolites, and chemicals. From a pathogenic point of view, they are divided into non-infectious and infectious granulomas. Pathophysiological mechanisms are still poorly understood. Non-infectious granulomatous skin diseases include granuloma annulare, necrobiosis lipoidica, rheumatic nodules, foreign body granulomas, cutaneous sarcoidosis, and interstitial granulomatous dermatitis...
February 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29314333/programmed-cell-death-1-blockade-induced-cutaneous-sarcoid-like-epithelioid-granulomas-in-advanced-melanoma-a-case-report
#6
T Ogawa, Y Ishitsuka, K Iwamoto, H Koguchi-Yoshioka, R Tanaka, R Watanabe, Y Fujisawa, M Fujimoto
Sarcoidosis is a chronic, systemic inflammatory disorder of unknown etiology that is characterized by the formation of noncaseating granuloma in affected organs, most commonly the lung.1 In pulmonary sarcoidosis patients, the T helper 1 (Th1) cytokine profile of CD4+ as well as CD8+ T cells was demonstrated in bronchoalveolar lavage fluid.2 However, there has been no detailed description of a lymphocyte profile in cutaneous sarcoid-like epithelioid granulomas. Here, we report a case of sarcoid-like epithelioid granulomas induced by nivolumab in a patient with advanced melanoma and we performed functional lymphocyte analysis of the granuloma lesions...
January 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29277453/sarcoidosis-post-anti-pd-1-therapy-mimicking-relapse-of-metastatic-melanoma-in-a-patient-undergoing-complete-remission
#7
N Yatim, C Mateus, P Charles
Novel treatments of metastatic melanoma include the usage of checkpoint inhibitors such as anti-cytotoxic-T-lymphocyte-associated antigen (CTLA-4) or anti-programmed death-1 (PD-1) antibodies, which are immunomodulatory antibodies that enhance the immune response against tumors. While they have substantially improved the prognosis for patients, these therapies are associated with a large spectrum of immune-related adverse effects (irAEs). We report a patient developing pulmonary and cutaneous sarcoidosis after pembrolizumab therapy while complete regression of stage IV melanoma was perceived...
December 22, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29242948/light-and-laser-modalities-in-the-treatment-of-cutaneous-sarcoidosis-a-systematic-review
#8
Ana Luiza Lima, Steven Goetze, Tanja Illing, Peter Elsner
No abstract text is available yet for this article.
December 15, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29240869/recalcitrant-diffuse-cutaneous-sarcoidosis-with-perianal-involvement-responding-to-adalimumab
#9
George F Cohen, Christopher M Wolfe
<p>Recalcitrant cutaneous sarcoidosis with perianal involvement is rare. To our knowledge we present the first documented case of cutaneous sarcoidosis with perianal involvement successfully treated with adalimumab.</p> <p><em>J Drugs Dermatol. 2017;16(12):1305-1306.</em></p>.
December 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29232421/ulcerative-sarcoidosis-a-prototypical-presentation-and-review
#10
Emily Powell, Ted Rosen
Although rare, ulcerative sarcoidosis is an acknowledged morphologic variant of cutaneous sarcoidosis encountered in both the United States and worldwide, particularly in patients with skin of color. Herein, we present a patient with prototypical ulcerative sarcoidosis to highlight this unusual presentation of a relatively rare cutaneous condition. We also review 34 additional cases drawn from the English-language literature to define historical presentation, associated findings, treatments, and outcomes.
November 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29221649/-two-cases-of-granuloma-annulare-under-anti-pd1-therapy
#11
R Charollais, F Aubin, B Roche-Kubler, E Puzenat
BACKGROUND: Granuloma annulare as a granulomatous cutaneous reaction may be drug-induced. Immune checkpoint inhibitors including programmed death-1 (PD-1) inhibitors show remarkable antitumor activity and are approved for melanoma and other cancers. Different immune-related adverse effects have been described. We report herein a rare adverse effect of anti-PD1 therapy given for metastatic melanoma : granuloma annulare. PATIENTS AND METHODS: Two women receiving pembrolizumab metastatic melanoma presented with granuloma annulare...
December 5, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29197467/diagnostic-tools-to-use-when-we-suspect-an-allergic-reaction-to-a-tattoo-a-proposal-based-on-cases-at-our-hospital
#12
I González-Villanueva, J F Silvestre Salvador
INTRODUCTION: Tattooing has become a popular practice in western countries, particularly among younger populations. Tattoos, however, can cause complications, such as infections, allergic or foreign-body reactions, and even systemic inflammatory responses. PATIENTS AND METHODS: We conducted a retrospective study of all patients seen for tattoo-related complications at our skin allergy unit between January 2002 and December 2016. RESULTS: We studied 23 patients...
November 29, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29186261/cutaneous-sarcoidosis-and-secondary-open-angle-glaucoma-in-a-patient-case-report-and-literature-review
#13
Qiancheng Deng, Shu Ding, Shengbo Yang, JinHua Huang
The current report presents the case of a 41-year-old male patient with a two-month history of asthenopia and plaques in the frontotemporal region. Computed tomography revealed bilateral hilar and mediastinal lymphadenopathy. Ophthalmological examination showed elevated intraocular pressure. Skin biopsy demonstrated aa dermal inflammatory infiltrate composed mainly of epithelioid cells and a few multinucleated giant cells, but no obvious lymphocytes. Findings of thorough physical examinations and auxiliary examinations suggested the presence of cutaneous sarcoidosis and secondary open-angle glaucoma...
May 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29165307/cutaneous-sarcoidosis-during-rituximab-treatment-for-microscopic-polyangiitis-an-uncommon-adverse-effect
#14
Leonardo Pescitelli, Giacomo Emmi, Lara Tripo, Linda Lazzeri, Maria Letizia Urban, Elena Silvesri, Margherita Vannucchi, Francesca Prignano
No abstract text is available yet for this article.
November 22, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29068075/histomorphometric-approach-to-differentiate-skin-lesions-of-tuberculoid-leprosy-from-sarcoidosis
#15
Fabiane Leonel Utino, Gislaine Vieira Damiani, Marina Garcia, Tânia Cristina Benetti Soares, Rafael Fantelli Stelini, Paulo Eduardo Neves Ferreira Velho, Elemir Macedo de Souza, Maria Letícia Cintra
BACKGROUND: More than 200 000 new cases of leprosy are detected worldwide annually. Physicians commonly have difficulty in differentiating tuberculoid form of leprosy (TL) from sarcoidosis' cutaneous manifestation. METHODS: Skin biopsies of 33 patients with TL and 24 with sarcoidosis were reviewed on hematoxylin and eosin- and Gomori-stained sections, in order to find reliable criteria for distinguishing one disease from another. RESULTS: Nine of the 24 features analyzed presented significant predictive value for diagnosis (P < ...
October 25, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29033821/certolizumab-pegol-induced-folliculitis-like-lichenoid-sarcoidosis-in-a-patient-with-rheumatoid-arthritis
#16
Hiroyuki Sakai, Wakana Nomura, Motoshi Sugawara
Anti-tumor necrosis factor α (TNF-α) biologic agents are used for treating refractory sarcoidosis. However, sarcoidosis-like epithelioid cell granulomas may develop during anti-TNF-α treatment. A 63-year-old man suffering from rheumatoid arthritis was treated with oral methotrexate and methylprednisolone for 4 years. He subsequently started biweekly subcutaneous injections of certolizumab pegol. Three months later, light red follicular papules developed on his chest and they spread over the trunk and bilateral upper arms...
September 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29026615/an-unusual-cutaneous-infection-caused-by-mycobacterium-marinum
#17
Federica Veronese, Elisa Zavattaro, Pamela Farinelli, Enrico Colombo, Paola Savoia
Introduction.Mycobacterium marinum is a non-tubercular mycobacterium residing in fresh or salt water (in tropical or temperate areas); it is a fish and human pathogen, and in immunocompromised patients can cause severe cutaneous and subcutaneous infections. Case presentation. A 46-year-old white man who underwent immunosuppressive therapy was admitted to our department in May 2016 for skin lesions previously diagnosed as 'unusual erysipelas'. We rejected the hypothesis of erysipelas, due to the clinical features, and our diagnostic hypotheses were oriented towards sporotrichosis, atypical mycobacteriosis, cutaneous tuberculosis and cutaneous sarcoidosis...
April 2017: JMM Case Reports
https://www.readbyqxmd.com/read/28990976/orbital-inflammation-as-a-presenting-sign-for-crest-syndrome
#18
Shirin W Hamed-Azzam, David P D'Cruz, David H Verity
A 61-year-old male was referred with a week's history of a painful and swollen left eye. Examination revealed normal visual acuities, left proptosis and global restriction of ocular ductions, and subretinal fluid at the macula. CT imaging confirmed thickening of the posterior scleral coat, with an associated choroidal effusion. Serology revealed positive antinuclear antibodies with a centromere staining pattern; subsequent rheumatology review revealed extensive telangiectasia with digital ulceration in both hands, and a diagnosis of limited cutaneous systemic sclerosis was made...
September 27, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28984765/cutaneous-sarcoidosis-a-retrospective-case-series-and-a-hospital-based-case-control-study-in-taiwan
#19
Kwei-Lan Liu, Wen-Chien Tsai, Chih-Hung Lee
Sarcoidosis is a systemic granulomatous disorder of unknown etiology often involving skin. Studies on cutaneous sarcoidosis and comorbidities are limited. This study is aimed to describe the clinical features of cutaneous sarcoidosis diagnosed in our hospital and to determine the relationships between cutaneous sarcoidosis and comorbidities.This retrospective study evaluates patients with cutaneous sarcoidosis in a tertiary center in Taiwan from 1996 to 2015. The records of 38 patients with cutaneous sarcoidosis were reviewed for clinical characteristics and evaluated by analysis of variance...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28969254/unusual-clinical-presentations-in-early-onset-childhood-sarcoidosis-a-correlation-or-coincidence
#20
Priyadarshini Sahu, Sudhanshu Sharma, Nidhi Sharma, Sarika Sharma, Shilpa Garg
Sarcoidosis is a multisystem granulomatous disease which frequently affects young adults. Because of its rarity, the exact incidence and prevalence of childhood sarcoidosis is not known. It mostly affects children of older age group i.e., 13-15 years. Early onset sarcoidosis (<5 years) is characterized by a triad of arthritis, uveitis and rash. Late onset sarcoidosis present with a multisystem disease similar to adults, with frequent pulmonary infiltrations and lymphadenopathy. Herein, we report a case of early-onset childhood sarcoidosis in a four-year-old female along with uncommon clinical features like cutaneous ulceration, onycholysis and geographical tongue and its rarity in the literature...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
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