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https://www.readbyqxmd.com/read/28088767/pharmacokinetic-study-of-anidulafungin-in-icu-patients-with-intra-abdominal-candidiasis
#1
H Dupont, L Massias, B Jung, N Ammenouche, P Montravers
BACKGROUND: Only limited pharmacokinetic data are available for anidulafungin in ICU patients, especially in patients treated for severe intra-abdominal infection (IAI). METHODS: This was a prospective multicentre observational study in ICU patients with suspected yeast IAI. All patients received an intravenous loading dose of 200 mg of anidulafungin, followed by 100 mg/day. Thirteen blood samples were drawn between day 1 and day 5 for pharmacokinetic analysis...
January 14, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28088529/effect-of-water-chemistry-on-disinfection-by-product-formation-in-the-complex-surface-water-system
#2
Rongjie Hao, Yan Zhang, Tingting Du, Li Yang, Adeyemi S Adeleye, Yao Li
The relationship between the disinfection by-products (DBPs) formed with chlorination and chloramination techniques and the water chemistry of Haihe River was compared. Samples were collected at 28 different points within the mainstream and tributaries of the river. The DBPs investigated include trihalomethanes (THMs), haloacetic acids (HAAs), haloacetonitriles (HANs), haloketones (HKs), and trichloronitromethane. THMs formed when the samples were chlorinated mostly exceeded 100 and 600 μg/L in the mainstream and tributaries and in the estuary, respectively...
December 8, 2016: Chemosphere
https://www.readbyqxmd.com/read/28088360/hollow-porous-ionic-liquids-composite-polymers-based-solid-phase-extraction-coupled-online-with-high-performance-liquid-chromatography-for-selective-analysis-of-hydrophilic-hydroxybenzoic-acids-from-complex-samples
#3
Xingping Dai, Dongsheng Wang, Hui Li, Yanyi Chen, Zhicheng Gong, Haiyan Xiang, Shuyun Shi, Xiaoqing Chen
Polar and hydrophilic properties of hydroxybenzoic acids usually made them coelute with interferences in high performance liquid chromatography (HPLC) analysis. Then selective analysis of them was necessary. Herein, hollow porous ionic liquids composite polymers (PILs) based solid phase extraction (SPE) was firstly fabricated and coupled online with HPLC for selective analysis of hydroxybenzoic acids from complex matrices. Hollow porous PILs were firstly synthesized using Mobil Composition of Matter No. 48 (MCM-48) spheres as sacrificial support, 1-vinyl-3-methylimidazolium chloride (VMIM(+)Cl(-)) as monomer, and ethylene glycol dimethacrylate (EGDMA) as cross-linker...
January 9, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28088117/adsorption-of-phosphate-from-aqueous-solution-using-iron-zirconium-modified-activated-carbon-nanofiber-performance-and-mechanism
#4
Weiping Xiong, Jing Tong, Zhaohui Yang, Guangming Zeng, Yaoyu Zhou, Dongbo Wang, Peipei Song, Rui Xu, Chen Zhang, Min Cheng
Phosphate (P) removal is significant for the prevention of eutrophication in natural waters. In this paper, a novel adsorbent for the removal of P from aqueous solution was synthesized by loading zirconium oxide and iron oxide onto activated carbon nanofiber (ACF-ZrFe) simultaneously. The adsorbent was characterized by scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) spectroscopy and X-ray photoelectron spectroscopy (XPS). The results showed that P adsorption was highly pH dependent and the optimum pH was found to be 4...
January 7, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28088107/gaas-laser-therapy-reestablishes-the-morphology-of-the-nmj-and-nachrs-after-injury-due-to-bupivacaine
#5
Cristiane Neves Alessi Pissulin, Paula Aiello Tomé de Souza Castro, Flávio Codina, Carina Guidi Pinto, Ivan Jose Vechetti-Junior, Selma Maria Michelin Matheus
BACKGROUND: Local anesthetics are used to relieve pre- and postoperative pain, acting on both sodium channels and nicotinic acetylcholine receptors (nAChR) at the neuromuscular junction (NMJ). Bupivacaine acts as a non-competitive antagonist and has limitations, such as myotoxicity, neurotoxicity, and inflammation. Low-level laser therapy (LLLT) has anti-inflammatory, regenerative, and analgesic effects. The aim of the present study was to evaluate the effects of a gallium arsenide laser (GaAs) on the morphology of the NMJ and nAChRs after application of bupivacaine in the sternomastoid muscle...
December 22, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28088012/new-4-4-chlorophenyl-2-2-6-2%C3%A2-terpyridine-ruthenium-ii-complexes-synthesis-characterization-interaction-with-dna-bsa-and-cytotoxicity-studies
#6
Milan M Milutinović, Ana Rilak, Ioannis Bratsos, Olivera Klisurić, Milan Vraneš, Nevenka Gligorijević, Siniša Radulović, Živadin D Bugarčić
In this study, we have developed a series of new monofunctional Ru(II) complexes of the general formula mer-[Ru(Cl-Ph-tpy)(N-N)Cl]Cl in which Cl-Ph-tpy is 4'-(4-chlorophenyl)-2,2':6',2″-terpyridine, N-N is a bidentate chelating ligand (1,2-diaminoethane (en, 1), 1,2-diaminocyclohexane (dach, 2) or 2,2'-bipyridine (bpy, 3)). All complexes were fully characterized by elemental analysis and spectroscopic techniques (IR, UV-Vis, 1D and 2D NMR). Their chemical behavior in aqueous solution was studied by UV-Vis and NMR spectroscopy showing that all compounds are relatively labile leading to the formation of the corresponding aqua species 1aq-3aq...
October 14, 2016: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28087906/-effect-and-its-molecular-mechanisms-of-curcumin-on-pulmonary-artery-smooth-muscle-cells-in-rat-model-with-chronic-obstructive-pulmonary-disease
#7
Xiangang Lin, Yenong Chen, Zhuqing Liu
Objective: To investigate the effects and the underlying molecular mechanisms of curcumin on pulmonary artery smooth muscle cells in rat model with chronic obstructive pulmonary disease (COPD). Methods: A total of 75 male Wistar rats were randomly divided into control group (group CN), model group (group M), low-dose curcumin group (group CL), medium-dose curcumin group (group CM) and high-dose curcumin group (group CH). HE staining was used to observe the morphology of pulmonary artery. Proliferating cell nuclear antigen (PCNA), apoptosis-related protein Bcl-2 and Bax were detected by immunohistochemical staining...
May 25, 2016: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/28087701/the-ubiquitin-ligase-nedd4l-regulates-the-na-k-2cl-co-transporter-nkcc1-slc12a2-in-the-colon
#8
Chong Jiang, Hiroshi Kawabe, Daniela Rotin
The ubiquitin ligase Nedd4-like (Nedd4L, or Nedd4-2) binds to and regulates stability of the epithelial Na+ channel (ENaC) in salt absorbing epithelia in the kidney, lung, and other tissues. Its role in the distal colon, which also absorbs salt and fluid and expresses ENaC, is unknown. Using conditional knockout approach to knockout Nedd4L in mice intestinal epithelium (Nedd4Lf/f;Vil-CreERT2) we show here that Nedd4L depletion leads to a higher steady-state short circuit current (Isc) in mouse distal colon tissue relative to controls...
January 13, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28087700/two-small-molecules-restore-stability-to-a-sub-population-of-the-cystic-fibrosis-transmembrane-conductance-regulator-with-the-predominant-disease-causing-mutation
#9
Xin Meng, Yiting Wang, Xiaomeng Wang, Joe A Wrennall, Tracy L Rimington, Hongyu Li, Zhiwei Cai, Robert C Ford, David N Sheppard
Cystic fibrosis (CF) is caused by mutations that disrupt the plasma membrane expression, stability, and function of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel. Two small molecules, the CFTR corrector lumacaftor and the potentiator ivacaftor, are now used clinically to treat CF, although some studies suggest that they have counteracting effects on CFTR stability. Here, we investigated the impact of these compounds on the instability of F508del-CFTR, the most common CF mutation...
January 13, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28087365/parasite-induced-increases-in-the-energy-costs-of-movement-of-host-freshwater-fish
#10
Ondřej Slavík, Pavel Horký, Karel Douda, Josef Velíšek, Jitka Kolářová, Pavel Lepič
Parasitization by the larvae (glochidia) of freshwater mussels can cause harm to a fish's gills, resulting in less effective respiration and/or reduced activity by the host fish. The impact of glochidia infections on the host's physiology remains poorly understood, and no information is available concerning energy consumption in parasitized fish. Hence, we obtained glochidia of the invasive unionid mussel Sinanodonta (Anodonta) woodiana and experimentally infected common carp, Cyprinus carpio, tagged with physiological sensors to measure energy consumption...
January 10, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28087074/quantifying-loading-toxic-concentrations-and-systemic-persistence-of-chloride-in-a-contemporary-mixed-land-use-watershed-using-an-experimental-watershed-approach
#11
J A Hubbart, E Kellner, L W Hooper, S Zeiger
A nested-scale experimental watershed study was implemented to quantify loading and persistence of chloride in an urbanizing, mixed-land-use watershed. A Midwest USA (Missouri) watershed was partitioned into five sub-basins with contrasting dominant land use. Streamwater was tested for chloride concentration four days per week from October 2009 through May 2014 at each site. Monitoring sites included co-located gauging and climate stations recording variables at 30-minute intervals. Results indicate significant (p<0...
January 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28086835/stunting-and-severe-stunting-among-children-under-5%C3%A2-years-in-nigeria-a-multilevel-analysis
#12
Blessing Jaka Akombi, Kingsley Emwinyore Agho, John Joseph Hall, Dafna Merom, Thomas Astell-Burt, Andre M N Renzaho
BACKGROUND: Stunting has been identified as one of the major proximal risk factors for poor physical and mental development of children under-5 years. Stunting predominantly occurs in the first 1000 days of life (0-23 months) and continues to the age of five. This study examines factors associated with stunting and severe stunting among children under-5 years in Nigeria. METHODS: The sample included 24,529 children aged 0-59 months from the 2013 Nigeria Demographic and Health Survey (NDHS)...
January 13, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28080044/structural-dependence-of-the-ising-type-magnetic-anisotropy-and-of-the-relaxation-time-in-mononuclear-trigonal-bipyramidal-co-ii-single-molecule-magnets
#13
Feng Shao, Benjamin Cahier, Eric Rivière, Régis Guillot, Nathalie Guihéry, Victoria E Campbell, Talal Mallah
This paper describes the correlation between Ising-type magnetic anisotropy and structure in trigonal bipyramidal Co(II) complexes. Three sulfur-containing trigonal bipyramidal Co(II) complexes were synthesized and characterized. It was shown that we can engineer the magnitude of the Ising anisotropy using ligand field theory arguments in conjunction with structural parameters. To prepare this series of compounds, we used, on the one hand, a tetradentate ligand containing three sulfur atoms and one amine (NS3(tBu)) and on the other hand three different axial ligands, namely, Cl(-), Br(-), and NCS(-)...
January 12, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28079707/effect-of-number-of-sprints-in-a-sit-session-on-change-in-vo2max-a-meta-analysis
#14
Niels Bj Vollaard, Richard S Metcalfe, Sean Williams
PURPOSE: Recent meta-analyses indicate that sprint interval training (SIT) improves cardiorespiratory fitness (V[Combining Dot Above]O2max), but the effects of various training parameters on the magnitude of the improvement remain unknown. The present meta-analysis examined the modifying effect of the number of sprint repetitions in a SIT session on improvements in V[Combining Dot Above]O2max. METHODS: The databases PubMed and Web of Science were searched for original studies that have examined pre- and post-training V[Combining Dot Above]O2max in adults following ≥2 weeks of training consisting of repeated (≥2) Wingate-type cycle sprints, published up to 1 May 2016...
January 10, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28079462/establishing-the-standard-method-of-cochlear-implant-in-rongchang-pig
#15
Wei Chen, Haijin Yi, Liang Zhang, Fei Ji, Shuolong Yuan, Yue Zhang, Lili Ren, Jianan Li, Lei Chen, Weiwei Guo, Shiming Yang
CONCLUSIONS: In this investigation, a large mammal, Rongchang pigs were used to successfully establish a research platform for cochlear implant study on the routine use of it in clinic. OBJECTIVE: The aim of this study was to establish a standard method of cochlear implant in a large mammal-pig. METHODS: Rongchang pigs were selected, then divided into two groups: normal-hearing group (Mitf +/+) and mutation group with hearing loss (Mitf -/-)...
January 12, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28079368/ligand-design-for-isomer-selective-oxorhenium-v-complex-synthesis
#16
Jinyong Liu, Xiaoge Su, Mengwei Han, Dimao Wu, Danielle L Gray, John R Shapley, Charles J Werth, Timothy J Strathmann
Recently, N,N-trans Re(O)(LN-O)2X (LN-O = monoanionic N-O chelates; X = Cl or Br prior to being replaced by solvents or alkoxides) complexes have been found to be superior to the corresponding N,N-cis isomers in the catalytic reduction of perchlorate via oxygen atom transfer. However, reported methods for Re(O)(LN-O)2X synthesis often yield only the N,N-cis complex or a mixture of trans and cis isomers. This study reports a geometry-inspired ligand design rationale that selectively yields N,N-trans Re(O)(LN-O)2Cl complexes...
January 12, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28079173/new-experimental-evidence-to-support-roaming-in-the-reaction-cl%C3%A2-%C3%A2-isobutene-i-c4h8
#17
Li-Wei Chen, Ching-Ming Hung, Hiroyuki Matsui, Yuan-Pern Lee
The reaction Cl + isobutene (i-C4H8) was reported by Suits et al. to proceed via, in addition to abstraction, an addition-elimination path following a roaming excursion of Cl; a near-zero translational energy release and an isotropic angular distribution observed at a small collision energy characterized this mechanism. We employed a new experimental method to further characterize this roaming mechanism through observation of the internal distribution of HCl (v, J) and their temporal behavior upon irradiation of a mixture of Cl2C2O2 and i-C4H8 in He or Ar buffer gas...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28078852/cell-based-therapies-for-experimental-diabetic-nephropathy-a-systematic-review-and-meta-analysis
#18
H J Tang, Z G Tian, X Yang, Y Cao, W G Li
Study has shown that stem cell–based therapies are promising strategies in the treatment of several chronic diseases, but their overall benefit in the treatment of diabetic nephropathy (DN) remains controversial. The purpose of this study is to summarize the evidence of the effect of cell-based therapy in the treatment of DN to guide future clinical trials. We searched PubMed, EmBase, and the Cochrane Library for studies from the inception of cell-based therapies up to July 2015. We included animal trials that reported the effects of cell-based therapy on kidney function, cardiovascular risk factors, and body factors...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28078590/quantifying-cd95-cl-cd95l-implications-in-cell-mechanics-and-membrane-tension-by-atomic-force-microscopy-based-force-measurements
#19
Anaïs Sadoun, Pierre-Henri Puech
Atomic force microscopy (AFM) is an invaluable tool to investigate the structure of biological material surfaces by imaging them at nanometer scale in physiological conditions. It can also be used to measure the forces and mechanics from single molecule interaction to cell-cell adhesion. Here, we present a methodology that allows to quantify cell elastic properties (using the Young modulus) and cell membrane tension modulated by CD95/cl-CD95L interactions by coupling nanoindentation and membrane tube pulling using suitably decorated AFM levers...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28078588/boyden-chamber-assay-to-study-of-cell-migration-induced-by-metalloprotease-cleaved-cd95l
#20
Amanda Poissonnier, Patrick Legembre
CD95 receptor, also called Fas or Apo-1, is a member of the tumor necrosis factor receptors (TNF-R) superfamily (Itoh and Nagata, J Biol Chem 268:10932-10937, 1993). Its cognate ligand, CD95L, is a transmembrane cytokine, which can be cleaved by metalloproteases (Matsuno et al., J Rheumatol 28:22-28, 2001; Vargo-Gogola et al., Arch Biochem Biophys 408:155-161, 2002; Kiaei et al., Exp Neurol 205:74-81, 2007; Schulte et al., Cell Death Differ 14:1040-1049, 2007) releasing a soluble ligand into the bloodstream...
2017: Methods in Molecular Biology
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