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https://www.readbyqxmd.com/read/28445932/high-cftr-expression-in-philadelphia-chromosome-positive-acute-leukemia-protects-and-maintains-continuous-activation-of-bcr-abl-and-related-signaling-pathways-in-combination-with-pp2a
#1
Xi Yang, Tianyou Yan, Yuping Gong, Xuehua Liu, Huaqin Sun, Wenming Xu, Chunsen Wang, Duolan Naren, Yuhuan Zheng
Cystic fibrosis transmembrane conductance regulator (CFTR) is classified as an anion channel transporter of Cl- and HCO3-. Through interactions with its PDZ domain, CFTR is capable of regulating other proteins, such as protein phosphatase 2A (PP2A). The aberrant expression and mutation of CFTR have been observed in several tumor, but not in philadelphia chromosome-positive(Ph+) acute leukemia, including Ph+ B cell acute lymphoblastic leukemia(Ph+ B-ALL) and chronic myelogenous leukemia blast crisis phases (CML-BC)...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28445640/a-highly-active-and-stable-fe-n-c-catalyst-for-oxygen-depolarized-cathode-applications
#2
Jingkun Li, Qingying Jia, Shraboni Ghoshal, Wentao Liang, Sanjeev Mukerjee
Anion immunity towards oxygen reduction reaction (ORR) has tremendous implications in electrocatalysis with applications for fuel cells, metal-air batteries, and oxygen depolarized cathodes (ODCs) in anodic evolution of chlorine. The necessity for exploring ORR catalysts with immunity to anion adsorption is particularly significant considering that platinum group metal (PGM) catalysts are costly and highly vulnerable to impurities such as halides. Herein, we report a metal organic framework (MOF) derived Fe-N-C catalyst that exhibits a dramatically improved half-wave potential of 240 mV compared to the state-of-the-art RhxSy/C catalyst in a rotating disk electrode in the presence of Cl-...
April 26, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28445281/relationship-between-the-abnormal-diastolic-vortex-structure-and-impaired-left-ventricle-filling-in-patients-with-hyperthyroidism
#3
Bin-Yu Zhou, Ming-Xing Xie, Jing Wang, Xin-Fang Wang, Qing Lv, Man-Wei Liu, Shuang-Shuang Kong, Ping-Yu Zhang, Jin-Feng Liu
Intraventricular hydrodynamics plays an important role in evaluating cardiac function. Relationship between diastolic vortex and left ventricular (LV) filling is still rarely elucidated. The aim of this study was to evaluate the evolution of vortex during diastole in hyperthyroidism (HT) and explore the alteration of hydromechanics characteristics with sensitive indexes.Forty-three patients diagnosed with HT were classified into 2 groups according to whether myocardial damage existed: simple hyperthyroid group (HT1, n = 21) and thyrotoxic cardiomyopathy (HT2, n = 22)...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28445043/assembly-of-effective-halide-receptors-from-components-comparing-hydrogen-halogen-and-tetrel-bonds
#4
Steve Scheiner
Receptors for halide anions are constructed based on the imidazolium unit, and then replacing the H-bonding C-H group first by halogen-bonding C-I and then by tetrel-bonding C-SnH3 and C-SiF3. Attaching a phenyl ring to any of these species has little effect on its ability to bind a halide, but incorporation of a second imidazolium to the benzene connector, forming a bidentate dicationic receptor, greatly enhances the binding. Addition of electron-withdrawing F atoms to each imidazolium adds a further increment...
April 26, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28444920/synthesis-of-mono-bis-and-tris-pentafluoroethyl-tin-derivatives-c2f5-4-nsnxn-x-ph-me-cl-br-cp-n%C3%A2-%C3%A2-1-3
#5
Johannes Klösener, Markus Wiesemann, Mark Niemann, Beate Neumann, Hans-Georg Stammler, Berthold Hoge
For (pentafluoroethyl)phenylstannanes, (C2F5)4-nSnPhn (n = 1-3), and dimethylbis(pentafluoroethyl)stannane, (C2F5)2SnMe2, a high yield synthesis was developed by the use of LiC2F5 as a C2F5 transfer reagent. The treatment of these products with gaseous hydrogen chloride or hydrogen bromide afforded (C2F5)4-nSnXn (X = Cl, Br; n = 1-3) in good yields. The (pentafluoroethyl)stannanes were fully characterized by 1H, 13C, 19F and 119Sn NMR, IR spectroscopy and mass spectrometry. The treatment of the (pentafluoroethyl)tin halides (C2F5)4-nSnXn with 1,10-phenanthroline (phen) led to the formation of the corresponding octahedrally coordinated complexes [(C2F5)4-nSnXn(phen)], the structures of which were elucidated by X-ray diffraction analyses...
April 26, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28444754/retrospective-study-on-the-occurrence-of-canine-lymphoma-and-associated-breed-risks-in-a-population-of-dogs-in-nsw-2001-2009
#6
Ppy Yau, N K Dhand, P C Thomson, R M Taylor
OBJECTIVE: To identify risk factors for canine lymphoma in dogs from New South Wales, Australia, and to compare factors affecting remission duration. METHODS: Client-owned dogs diagnosed with lymphoma presented to the University Veterinary Teaching Hospital (UVTH), University of Sydney, between 2001 and 2009 (n = 134) were compared with a control population of dogs seen in that period of time with a diagnosis other than lymphoma to evaluate association of explanatory variables (breed, age and sex) with the outcome (case or control status)...
May 2017: Australian Veterinary Journal
https://www.readbyqxmd.com/read/28444564/response-to-lead-pollution-mycorrhizal-pinus-sylvestris-forms-the-biomineral-pyromorphite-in-roots-and-needles
#7
Maria L Bizo, Sandor Nietzsche, Ulrich Mansfeld, Falko Langenhorst, Juraj Majzlan, Jörg Göttlicher, Alexandru Ozunu, Steffi Formann, Katrin Krause, Erika Kothe
The development of mycorrhized pine seedlings grown in the presence of lead was assessed in order to investigate how higher plants can tolerate lead pollution in the environment. Examination with scanning electron microscopy (SEM) revealed that Pb uptake was prominent in the roots, while a smaller amount was found in pine needles, which requires symplastic uptake and root-to-shoot transfer. Lead was concentrated in nanocrystalline aggregates attached to the cell wall and, according to elemental microanalyses, is associated with phosphorus and chlorine...
April 25, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28444427/population-pharmacokinetic-modelling-of-doxorubicin-and-doxorubicinol-in-children-with-cancer-is-there-a-relationship-with-cardiac-troponin-profiles
#8
Kuhan Kunarajah, Stefanie Hennig, Ross L G Norris, Michael Lobb, Bruce G Charles, Ross Pinkerton, Andrew S Moore
PURPOSE: Anthracyclines are a mainstay of the treatment of several childhood malignancies, but their utility is limited by dose-related cardiotoxicity. This study is aimed to explore the link between exposure of paediatric cancer patients to doxorubicin and its metabolite doxorubicinol, and cardiac troponin I (cTnI). METHODS: In a prospective pilot study plasma doxorubicin, doxorubicinol, and cTnI concentrations were measured in samples from children undergoing cancer chemotherapy...
April 25, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28443875/investigating-anomalous-thermal-expansion-of-copper-halides-by-inelastic-neutron-scattering-and-ab-initio-phonon-calculations
#9
Abhijith M Gopakumar, M K Gupta, R Mittal, S Rols, S L Chaplot
We investigate the detailed lattice dynamics of copper halides, CuX (X = Cl, Br, and I), using neutron inelastic scattering measurements and ab initio calculations aimed at a comparative study of their thermal expansion behavior. We identify the low energy phonons which soften with pressure and are responsible for negative thermal expansion. The eigenvector analysis of these modes suggests that softening of the transverse-acoustic modes would lead to NTE in these compounds. The calculations are in very good agreement with our measurements of phonon spectra and thermal expansion behavior as reported in the literature...
April 26, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28443694/fractal-features-and-surface-micromorphology-of-unworn-surfaces-of-rigid-gas-permeable-contact-lenses
#10
Ştefan Ţălu, Miroslaw Bramowicz, Slawomir Kulesza, Ilenia Fiorillo, Stefano Giovanzana
PURPOSE: The aim of this exploratory study was to investigate the micromorphology of surfaces of rigid gas permeable (RGP) contact lenses (CLs) using atomic force microscopy (AFM) followed by fractal analysis. MATERIALS AND METHODS: In order to characterize in a quantitative manner the micromorphology of surfaces of new and unworn RGP CLs made of twelve different materials, AFM was taken and then analyzed using fractal methods. Surface topography was sampled in an intermittent-contact mode in air, on square areas of 5 × 5 µm(2) (MultiMode with Nanoscope V (Bruker)...
April 26, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28443335/selective-complexation-of-cyanide-and-fluoride-ions-with-ammonium-boranes-a-theoretical-study-on-sensing-mechanism-involving-intramolecular-charge-transfer-and-configurational-changes
#11
Haamid Rasool Bhat, Prakash Chandra Jha
The anion binding selectivity and the recognition mechanism of two isomeric boranes namely 4-[bis(2,4,6-trimethylphenyl)boranyl]-N,N,N-trimethylaniline ([p-(Mes2B)C6H4(NMe3)]+, 1, where 'Mes' represents mesitylene and 'Me' represents methyl) and 2-[bis(2,4,6-trimethylphenyl)boranyl]-N,N,N-trimethylaniline ([o-(Mes2B)C6H4(NMe3)]+, 2) has been investigated using density functional theory (DFT) and time dependent-density functional theory (TD-DFT) methods. Natural population analysis indicates that the central boron atoms in 1 and 2 are the most active centers for nucleophilic addition of anions...
April 26, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28443326/ionic-liquid-silica-precursors-via-solvent-free-sol-gel-process-and-their-application-in-epoxy-amine-network-a-theoretical-experimental-study
#12
Magdalena Perchacz, Ricardo Keitel Donato, Leandro Seixas, Alexander Zhigunov, Rafal Konefal, Magdalena Serkis-Rodzeń, Hynek Benes
This work describes the solvent-free sol-gel synthesis of epoxy-functionalized silica-based precursors, in the presence of 1-butyl-3-methylimidazolium-based ionic liquids (ILs) containing different anions - chloride (Cl(-)) and methanesulfonate (MeSO3(-)). The IL-driven sol-gel mechanisms were investigated in details using experimental characterizations ((29)Si NMR and ATR FTIR spectroscopy) and a theoretical computational method based on density functional theory (DFT). We observed a complex IL's influence on both hydrolysis and condensation steps, involving especially H-bonding and Coulomb coupling stabilization of the process intermediates...
April 26, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28442639/astaxanthin-increases-progesterone-production-in-cultured-bovine-luteal-cells
#13
Hachiro Kamada, Satoshi Akagi, Shinya Watanabe
Although astaxanthin (AST) is known to be a strong antioxidant, its effects on reproductive function in domestic animals have not yet been elucidated in detail. Therefore, we investigated the effects of AST on luteal cells, which produce progesterone (P4), an important hormone for maintaining pregnancy. Luteal cells were prepared by collagenase dispersion of the corpus luteum (CL). The addition of racemic AST at a low concentration (<10 nM) to cultured bovine luteal cells increased P4 in the culture medium (P<0...
April 23, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28442572/the-phospholipase-ipla2%C3%AE-is-a-major-mediator-releasing-oxidized-aliphatic-chains-from-cardiolipin-integrating-mitochondrial-bioenergetics-and-signaling
#14
Gao-Yuan Liu, Sung Ho Moon, Christopher M Jenkins, Maoyin Li, Harold F Sims, Shaoping Guan, Richard W Gross
Cardiolipin (CL) is a dimeric phospholipid with critical roles in mitochondrial bioenergetics and signaling. Recently, inhibition of the release of oxidized fatty acyl chains from CL by the calcium independent phospholipase A2γ (iPLA2γ) selective inhibitor (R)-BEL suggested that iPLA2γ is responsible for the hydrolysis of oxidized CL and subsequent signaling mediated by the released oxidized fatty acids. However, chemical inhibition by BEL is subject to off-target pharmacologic effects. Accordingly, to unambiguously determine the role of iPLA2γ in the hydrolysis of oxidized CL, we compared alterations in oxidized CLs and the release of oxidized aliphatic chains from CL in experiments with purified recombinant iPLA2γ, germline iPLA2γ(-/-) mice, cardiac myocyte-specific iPLA2γ transgenic mice, and wild-type mice...
April 25, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28442063/peri-ovulatory-endocrine-regulation-of-the-prostanoid-pathways-in-the-bovine-uterus-at-early-dioestrus
#15
Milena Lopes Oliveira, Fabio Luiz D'Alexandri, Guilherme Pugliesi, Veerle Van Hoeck, Fernando Silveira Mesquita, Claudia M B Membrive, João Alberto Negrão, Craig E Wheelock, Mario Binelli
We hypothesised that different endocrine profiles associated with pre-ovulatory follicle (POF) size would impact on uterine prostanoid pathways and thereby modulate the histotroph composition. Beef cows (n=15 per group) were hormonally manipulated to have small (SF-SCL group) or large (LF-LCL group) pre-ovulatory follicles (POF) and corpora lutea (CL). Seven days after induction of ovulation, animals were slaughtered and uterine tissues and flushings were collected for quantification of prostanoids. The POF and CL size and the circulating progesterone concentrations at Day 7 were greater (P<0...
March 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28442057/follicle-vascularity-coordinates-corpus-luteum-blood-flow-and-progesterone-production
#16
S G S de Tarso, G D A Gastal, S T Bashir, M O Gastal, G A Apgar, E L Gastal
Colour Doppler ultrasonography was used to compare the ability of preovulatory follicle (POF) blood flow and its dimensions to predict the size, blood flow and progesterone production capability of the subsequent corpus luteum (CL). Cows (n=30) were submitted to a synchronisation protocol. Follicles ≥7mm were measured and follicular wall blood flow evaluated every 12h for approximately 3.5 days until ovulation. After ovulation, cows were scanned daily for 8 days and similar parameters were evaluated for the CL...
March 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28441922/fluid-displacement-from-intraluminal-thrombus-of-abdominal-aortic-aneurysm-as-a-result-of-uniform-compression
#17
Kim van Noort, Richte Cl Schuurmann, Bryan Wermelink, Cornelis H Slump, Karel C Kuijpers, Jean-Paul Pm de Vries
Objectives The results after aneurysm repair with an endovascular aneurysm sealing (EVAS) system are dependent on the stability of the aneurysm sac and particularly the intraluminal abdominal aortic thrombus (ILT). The postprocedural ILT volume is decreased compared with preprocedural ILT volume in aortic aneurysm patients treated with EVAS. We hypothesize that ILT is not stable in all patients and pressurization of the ILT may result in displacement of fluids from the ILT, no differently than serum is displaced from whole blood when it settles...
January 1, 2017: Vascular
https://www.readbyqxmd.com/read/28441606/growth-inhibition-and-antibiofilm-potential-of-ag-nanoparticles-coated-with-lectin-an-arthropod-immune-molecule
#18
Sangily Jayanthi, Sathappan Shanthi, Baskaralingam Vaseeharan, Narayanan Gopi, Marimuthu Govindarajan, Naiyf S Alharbi, Shine Kadaikunnan, Jamal M Khaled, Giovanni Benelli
Lectins from the haemolymph of arthropods, including crustaceans, are molecules potentially involved in the immune recognition and phagocytosis. Here, lectin was purified from the haemolymph of blue swimmer crab Portunus pelagicus, using mannose-coupled sepharose CL-4B affinity column chromatography. In SDS-PAGE analysis, lectin showed a molecular mass of approximately 155kDa. The synthesis of lectin-coated silver nanoparticles (lectin-coated AgNPs) was confirmed by UV-Vis spectroscopy, XRD, FTIR, SEM, TEM, SAED, and EDX analysis...
April 13, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28441602/fluoride-and-iodine-enrichment-in-groundwater-of-north-china-plain-evidences-from-speciation-analysis-and-geochemical-modeling
#19
Junxia Li, Hailing Zhou, Kun Qian, Xianjun Xie, Xiaobin Xue, Yijun Yang, Yanxin Wang
To better understand the enrichment of fluoride and iodine in groundwater at North China Plain (NCP), speciation analysis and geochemical modeling were conducted to identify the key hydrochemical processes controlling their mobilization in groundwater system. Groundwater fluoride and iodine concentrations ranged from 0.18 to 5.59mg/L and from 1.51 to 1106μg/L, respectively, and approximately 63% and 32.3% of groundwater fluoride and iodine were higher than the guidelines for drinking water (1.5mg/L and 150μg/L)...
April 22, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28441592/characterization-of-major-natural-and-anthropogenic-source-profiles-for-size-fractionated-pm-in-yangtze-river-delta
#20
Pulong Chen, Tijian Wang, Mei Dong, Matthew Kasoar, Yong Han, Min Xie, Shu Li, Bingliang Zhuang, Mengmeng Li, Tunan Huang
Samples of size-fractionated particles were collected from local natural and anthropogenic sources in two industrial cities in the Yangtze River Delta, using either grab/resuspension sampling or ambient air sampling. The chemical characterizations of twenty one source profiles were obtained, based on elements (Al, As, Ca, Cd, Cr, Cu, Fe, K, Mg, Mn, Na, Pb and Zn), soluble ions (Cl(-), NO3(-), SO4(2-), NH4(+), K(+), Na(+) and Ca(2+)) and carbonaceous material such as organic carbon (OC) and elemental carbon (EC)...
April 22, 2017: Science of the Total Environment
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