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Babil Menjón, Miguel Baya, Alberto Pérez-Bitrián, Sonia Martínez-Salvador, José María Casas, Jesús Orduna
The anionic trifluoromethyl-gold(I) derivatives [CF₃AuX]⁻, which have been prepared and isolated as their [PPh₄]⁺ salts in good yield, undergo thermally-induced difluorocarbene extrusion in the gas phase giving rise to the mixed gold(I) fluorohalide complexes [F-Au-X]⁻ (X = Cl, Br, I). These triatomic species have been detected by tandem mass spectrometry (MS2) experiments and their properties have been analyzed by DFT methods. The CF₂ extrusion mechanism from the Au-CF₃ moiety serves as a model for the CF₂ insertion into the Au-F bond, since both reactivity channels are connected by the microreversibility principle...
December 9, 2016: Chemistry: a European Journal
Sergio M Borghi, Victor Fattori, Ivete Conchon-Costa, Phileno Pinge-Filho, Wander R Pavanelli, Waldiceu A Verri
The complex life cycle and immunopathological features underpinning the interaction of Leishmania parasites and their mammalian hosts poses frequent poorly explored and inconclusively resolved questions. The altered nociceptive signals over the course of leishmaniasis remain an intriguing issue for nociceptive and parasitology researchers. Experimental investigations have utilized behavioral, morphological, and neuro-immune approaches in the study of experimental cutaneous leishmaniasis (CL). The data generated indicates new venues for the study of the pathological characteristics of nociceptive processing in this parasitic disease...
December 9, 2016: Parasitology Research
Bo Yu, Yu Jiang, Lingling Jin, Tonghui Ma, Hong Yang
Epithelial chloride channels provide the pathways for fluid secretion in the intestine. Cystic fibrosis transmembrane conductance regulator (CFTR) and calcium-activated chloride channels (CaCCs) are the main chloride channels in the luminal membrane of enterocytes. These transmembrane proteins play important roles in many physiological processes. In this study, we have identified a flavonoid quercetin as a modulator of CaCC chloride channel activity. Fluorescence quenching assay showed that quercetin activated Cl(-) transport in a dose-dependent manner, with EC50 ~37 μM...
2016: Frontiers in Physiology
Yanyan Wang, Lihong Zhang, Dingding Wang, Xiuyun Guo, Shihua Wu
Counter-current chromatography (CCC) is a solid support-free liquid-liquid partition chromatography and has wide applications. However, CCC separation is still a challenging process and the selection of appropriate solvent system for separation of target compound(s) is still relatively time-consuming. In this work, we introduced a room temperature ionic liquids-based salting-in strategy for the rapid selection of suitable solvent systems for CCC separation. In the randomly selected solvent systems, such as ethyl acetate-water, n-butanol-water, n-pentanol-water, n-hexanol-water, and n-octanol-water, several ionic liquids such as [AMIM]Cl, [MAMIM]Cl, and [BMIM]Cl can increase the solubility of the solutes in the lower phase, which made a dose-dependent decreasing of partition coefficient of solute in the two-phase solvent system...
November 30, 2016: Journal of Chromatography. A
Yitao Pan, Yingshuang Zhu, Tongzhang Zheng, Qianqian Cui, Stephen L Buka, Bin Zhang, Yong Guo, Wei Xia, Leo Wai-Yin Yeung, Yuanyuan Li, Aifen Zhou, Lin Qiu, Hongxiu Liu, Minmin Jiang, Chuansha Wu, Shunqing Xu, Jiayin Dai
Per- and polyfluoroalkyl substances (PFASs) may cross the placental barrier and lead to fetal exposure. However, little is known about the factors that influence maternal-fetal transfer of these chemicals. PFAS concentrations were analyzed in 100 paired samples of human maternal sera collected in each trimester and cord sera at delivery; these samples were collected in Wuhan, China, 2014. Linear regression was used to estimate associations of transfer efficiencies with factors. Chlorinated polyfluorinated ether sulfonates (Cl-PFAESs: 6:2 and 8:2) were frequently detected (> 99%) in maternal and cord sera...
December 8, 2016: Environmental Science & Technology
Tomohito Kameda, Jumpei Oba, Toshiaki Yoshioka
Mg-Al layered double hydroxide intercalated with NO3(-) and Mg-Al oxide were found to remove hazardous materials such as B and As, as well as Cl(-) and SO4(2-), from artificial and real hot spring wastewater. However, compared with the mixture of Al2(SO4)3 and Ca(OH)2, both adsorbents were inferior for the removal of B from real hot spring wastewater. Both adsorbents were also found to remove F(-) and PO4(3-) from artificial semiconductor plant wastewater. Both adsorbents have the same ability to remove B from landfill wastewater as the mixture of Al2(SO4)3 and Ca(OH)2; furthermore, both remove Cl(-), Br(-), and SO4(2-)...
December 5, 2016: Journal of Environmental Management
Shu-Hua Zhang, Ji-Ming Wang, Hai-Yang Zhang, Yi-Peng Fan, Yu Xiao
Four coordination polymers, formulated as [Zn(L(1))2]n (1), [Cd(L(1))2]n (2), [Zn(L(2))2]n (3) and [Cd(L(2))2]n (4) (HL1 is (E)-2-(((4H-1,2,4-triazol-4-yl)imino)methyl)-4,6-dibromophenol; HL2 is (E)-2-(((4H-1,2,4-triazol-4-yl)imino)methyl)-4,6-dichlorophenol) have been synthesized through vial reactions. The four compounds were structurally characterized by single crystal X-ray diffraction, elemental analysis, PXRD, and fluorescence spectroscopy. For 1-4, a detailed analysis of Hirshfeld surfaces and fingerprint plots facilitates a comparison of intermolecular interactions, which are crucial in building different supramolecular architectures...
December 8, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Mareike Binder, Claudio Schrenk, Andreas Schnepf
The number of well-characterized metalloid tin clusters, synthesized by applying the disproportionation of a metastable Sn(I) halide in the presence of a sterically demanding ligand, has increased in recent years. The metastable Sn(I) halide is synthesized at "outer space conditions" via the preparative co-condensation technique. Thereby, the subhalide is synthesized in an oven at high temperatures, around 1,300 °C, and at reduced pressure by the reaction of elemental tin with hydrogen halide gas (e.g., HCl)...
November 28, 2016: Journal of Visualized Experiments: JoVE
Pankaj Kumar Pandey, Kamla Rawat, V K Aswal, J Kohlbrecher, H B Bohidar
DNA dissolved in ionic liquid (IL) solution (1-ethyl-3-methylimidazolium chloride, [C2mim][Cl]) showed a transition to the gel phase ([DNA] ≥ 1% (w/v)). The gelation time was 400 s for the 1% [IL] sample which reduced to 260 s for 5% [IL] concentration. Gelation times, obtained from the viscosity and ergodicity breaking from the dynamic structure factor data, were remarkably identical to each other. Correspondingly, the gelation temperature which was ∼60 °C increased to 67 °C with [IL] content. The small angle neutron scattering (SANS) structure factor profile revealed the presence of the following three distinct length scales: (a) mesh size, ξ ≈ 3 ± 0...
December 8, 2016: Physical Chemistry Chemical Physics: PCCP
Freja F Østerstrøm, Simone Thirstrup Andersen, Theis I Sølling, Ole John Nielsen, Mads P Sulbaek Andersen
The atmospheric fates of Z- and E-CF3CH[double bond, length as m-dash]CHCF3 have been studied, investigating the kinetics and the products of the reactions of the two compounds with Cl atoms, OH radicals, OD radicals, and O3. FTIR smog chamber experiments measured: k(Cl + Z-CF3CH[double bond, length as m-dash]CHCF3) = (2.59 ± 0.47) × 10(-11), k(Cl + E-CF3CH[double bond, length as m-dash]CHCF3) = (1.36 ± 0.27) × 10(-11), k(OH + Z-CF3CH[double bond, length as m-dash]CHCF3) = (4.21 ± 0.62) × 10(-13), k(OH + E-CF3CH[double bond, length as m-dash]CHCF3) = (1...
December 8, 2016: Physical Chemistry Chemical Physics: PCCP
Zi-Cheng Fu, Yong Xu, Sharon Lai-Fung Chan, Wei-Wei Wang, Fang Li, Fei Liang, Yong Chen, Zhe-Shuai Lin, Wen-Fu Fu, Chi-Ming Che
The CoP nanoparticle catalyst had excellent catalytic activity and a short catalytic induction period in the presence of anions, and high sustainability in ammonia borane hydrolysis, with an initial turnover frequency of 72.2 mol(H2) mol(CoP)(-1) min(-1) at ambient temperature. This value is unprecedented for noble-metal-free catalytic systems.
December 8, 2016: Chemical Communications: Chem Comm
Paolo Scudieri, Ilaria Musante, Ambra Gianotti, Oscar Moran, Luis J V Galietta
TMEM16A and TMEM16B are plasma membrane proteins with Ca(2+)-dependent Cl(-) channel function. By replacing the carboxy-terminus of TMEM16A with the equivalent region of TMEM16B, we obtained channels with potentiation of channel activity. Progressive shortening of the chimeric region restricted the "activating domain" to a short sequence close to the last transmembrane domain and led to TMEM16A channels with high activity at very low intracellular Ca(2+) concentrations. To elucidate the molecular mechanism underlying this effect, we carried out experiments based on double chimeras, Forster resonance energy transfer, and intermolecular cross-linking...
December 8, 2016: Scientific Reports
Camila Massae Sato, Maria Carmen Arroyo Sanchez, Beatriz Julieta Celeste, Malcolm S Duthie, Jeffrey Guderian, Steven G Reed, Maria Edileuza Felinto Brito, Marliane Batista Campos, Helia Valeria de Souza Encarnação, Jorge Guerra, Tirza Gabrielle Ramos de Mesquita, Suzana Kanawati Pinheiro, Rajendranath Ramasawmy, Fernando Tobias Silveira, Marina de Assis Souza, Hiro Goto
American tegumentary leishmaniasis (ATL; also known as cutaneous leishmaniasis (CL)) is caused by various species of protozoa of the genus Leishmania The diagnosis is achieved on a clinical, epidemiological and pathological basis supported with positive parasitological exams and demonstration of Leishmanin delayed-type hypersensitivity. Serological assays are not routinely used in the diagnosis because many are considered to have low sensitivity and the particular Leishmania species causing the disease can lead to variable perfomance...
December 7, 2016: Journal of Clinical Microbiology
Ciro Martins Gomes, Mariana Vicente Cesetti, Natália Aparecida de Paula, Sebastián Vernal, Gaurav Gupta, Raimunda Nonata Ribeiro Sampaio, Ana Maria Roselino
The precise diagnosis of American tegumentary leishmaniasis (ATL) is an essential task due to the disease's associated morbidity. A non-invasive, extremely sensitive and highly specific exam is critical, particularly for mucosal leishmaniasis (ML), in which a low parasite quantity is expected. We aimed to compare the diagnostic accuracy of swab and biopsy sample analysis using SYBR® Green- and TaqMan®-based real-time polymerase chain reaction (qPCR) assays with that of a composite reference standard consisting of the Montenegro skin test, serology, histopathology, smears, culture and conventional PCR...
December 7, 2016: Journal of Clinical Microbiology
Deepa L Ramamurthy, Gregg H Recanzone
The mammalian auditory cortex is necessary for spectral and spatial processing of acoustic stimuli. Most physiological studies of single neurons in the auditory cortex have focused on the onset and sustained portions of evoked responses, but there have been far fewer studies on the relationship between onset and offset responses. In the current study, we compared spectral and spatial tuning of onset and offset responses of neurons in primary auditory cortex (A1) and the caudolateral (CL) belt area of awake macaque monkeys...
December 7, 2016: Journal of Neurophysiology
Kwok-Tung Lu, Tai-Chun Huang, Ya-Hsin Tsai, Yi-Ling Yang
Na(+) -K(+) -2Cl(-) co-transporter (NKCC1) plays an important role in traumatic brain injury (TBI)-induced brain edema via the mitogen-activated protein kinases (MAPK) cascade. The transient receptor potential vanilloid type 4 (TRPV4) channel participates in neurogenic inflammation, pain transmission and edema. In this study, we investigated the relationship between NKCC1 and TRPV4 and the related signaling pathways in TBI-induced brain edema and neuronal damage. TBI was induced by the calibrated weight-drop device...
December 7, 2016: Journal of Neurochemistry
Can Hou, Ben Carter, Jonathan Hewitt, Trevor Francisa, Sharon Mayor
OBJECTIVE: To investigate the effect of mobile phone applications (apps) on glycemic control (HbA1c) in the self-management of diabetes. RESEARCH DESIGN AND METHODS: Relevant studies that were published between 1 January 1996 and 1 June 2015 were searched from five databases: Medline, CINAHL, Cochrane Library, Web of Science, and Embase. Randomized controlled trials that evaluated diabetes apps were included. We conducted a systematic review with meta-analysis and GRADE (Grading of Recommendations Assessment, Development and Evaluation) of the evidence...
November 2016: Diabetes Care
Michael E Hildebrand, Jian Xu, Annemarie Dedek, Yi Li, Ameet S Sengar, Simon Beggs, Paul J Lombroso, Michael W Salter
In chronic pain states, the neurotrophin brain-derived neurotrophic factor (BDNF) transforms the output of lamina I spinal neurons by decreasing synaptic inhibition. Pain hypersensitivity also depends on N-methyl-D-aspartate receptors (NMDARs) and Src-family kinases, but the locus of NMDAR dysregulation remains unknown. Here, we show that NMDAR-mediated currents at lamina I synapses are potentiated in a peripheral nerve injury model of neuropathic pain. We find that BDNF mediates NMDAR potentiation through activation of TrkB and phosphorylation of the GluN2B subunit by the Src-family kinase Fyn...
December 6, 2016: Cell Reports
Jonathan M Slezak, Rajeev I Desai, Jonathan L Katz
The present studies compared the acute effects of benztropine analogs (4-Cl-BZT, JHW 007, AHN 1-055), which are atypical dopamine uptake inhibitors, with those of the standard dopamine uptake inhibitors GBR 12909 and cocaine, on the reinforcing efficacy of food and food intake in male Sprague-Dawley rats. Repeated drug effects of JHW 007 on food intake were also determined. The number of ratios completed under a progressive-ratio schedule of food delivery was used as an index of reinforcing efficacy. Food intake was determined by measuring powdered laboratory-chow consumption during daily 40 min food-availability time periods...
December 6, 2016: Behavioural Pharmacology
Max Herzog, Dennis Konnerup, Ole Pedersen, Anders Winkel, Timothy David Colmer
Floods and salinization of agricultural land adversely impact global rice production. We investigated whether gas films on leaves of submerged rice delay salt entry during saline submergence. Two-week-old plants with leaf gas films (+GF) or with gas films experimentally removed (-GF) were submerged in artificial floodwater with 0 or 50 mM NaCl for up to 16 d. Gas films were present > 9 d on + GF plants after which gas films were diminished. Tissue ion analysis (Na(+) , Cl(-) and K(+) ) showed that gas films caused some delay of Na(+) entry, as leaf Na(+) concentration was 36-42% higher in -GF leaves than + GF leaves on d 1-5...
December 7, 2016: Plant, Cell & Environment
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