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https://www.readbyqxmd.com/read/28239970/atmospheric-pressure-chemical-ionization-of-explosives-induced-by-soft-x-radiation-in-ion-mobility-spectrometry-mass-spectrometric-investigation-of-the-ionization-reactions-of-drift-gasses-dopants-and-alkyl-nitrates
#1
Daniel Riebe, Alexander Erler, Thomas Ritschel, Toralf Beitz, Hans-Gerd Löhmannsröben, Andreas Beil, Michael Blaschke, Thomas Ludwig
A promising replacement for the radioactive sources commonly encountered in ion mobility spectrometers is a miniaturized, energy-efficient photoionization source that produce the reactant ions via soft X-radiation (2.8 keV). In order to successfully apply the photoionization source, it is imperative to know the spectrum of reactant ions and the subsequent ionization reactions leading to the detection of analytes. To that end, an ionization chamber based on the photoionization source that reproduces the ionization processes in the ion mobility spectrometer and facilitates efficient transfer of the product ions into a mass spectrometer was developed...
August 2016: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28239845/stimulation-of-na-k-pump-currents-by-epithelial-nicotinic-receptors-in-rat-colon
#2
Sandra Bader, Lena Lottig, Martin Diener
BACKGROUND AND PURPOSE: Acetylcholine-induced epithelial Cl(-) secretion is generally thought to be mediated by epithelial muscarinic receptors and nicotinic receptors on secretomotor neurons. However, recent data showed the expression of nicotinic receptors by intestinal epithelium and the stimulation of Cl(-) secretion by nicotine in the presence of the neurotoxin, tetrodotoxin. In the present study, we aimed to identify the transporters activated by epithelial nicotinic receptors and to clarify their role in cholinergic regulation of intestinal ion transport...
February 27, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28239706/structure-and-dynamic-nmr-behavior-of-rhodium-complexes-supported-by-lewis-acidic-group-13-metallatranes
#3
James T Moore, Nicholas E Smith, Connie C Lu
Monovalent Rh was installed into the group 13 metallatranes, M[N(o-(NCH2P((i)Pr)2)C6H4)3] (where M = Al and Ga, abbreviated as ML) to generate Rh → M bonds in the parent complexes, Cl-RhAlL (1-Cl) and Cl-RhGaL (2-Cl). The electron-withdrawing nature of the group 13 metalloids was probed by cyclic voltammetry, and Rh-Ga was found to be more electron-deficient than Rh-Al (Epc = -2.07 and -1.95 V vs. Fc(+)/Fc for 1-Cl and 2-Cl, respectively). Both 1-Cl and 2-Cl were further functionalized through metathesis reactions using MeLi to generate 1-CH3 and 2-CH3, respectively, or using LiHBEt3 to form 1-H and 2-H, respectively...
February 27, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28239699/stabilization-of-carbocations-ch3-c2h5-i-c3h7-tert-bu-and-cyclo-pentyl-in-solid-phases-experimental-data-versus-calculations
#4
Evgenii S Stoyanov, Anton S Nizovtsev
Comparison of experimental infrared (IR) spectra of the simplest carbocations (with the weakest carborane counterions in terms of basicity, CHB11Hal11(-), Hal = F, Cl) with their calculated IR spectra revealed that they are completely inconsistent, as previously reported for the t-Bu(+) cation [Stoyanov E. S., et al. J. Phys. Chem. A, 2015, 119, 8619]. This means that the generally accepted explanation of hyperconjugative stabilization of the carbocations should be revised. According to the theory, one CH bond (denoted as ) from each CH3/CH2 group transfers its σ-electron density to the empty 2pz orbital of the sp(2) C atom, whereas the σ-electron density on the other CH bonds of the CH3/CH2 group slightly increases...
February 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28238700/acute-toxicity-biochemical-toxicity-and-genotoxicity-caused-by-1-butyl-3-methylimidazolium-chloride-and-1-butyl-3-methylimidazolium-tetrafluoroborate-in-zebrafish-danio-rerio-livers
#5
Cheng Zhang, Yuting Shao, Lusheng Zhu, Jinhua Wang, Jun Wang, Yingying Guo
The present study examined the potential toxicity of 1-butyl-3-methylimidazolium chloride ([Bmim]Cl) and 1-butyl-3- methylimidazolium tetrafluoroborate ([Bmim]BF4) in the liver cells of zebrafish (Danio rerio) with different doses (20-160mg/L) on 7 and 14days. The effects of [Bmim]Cl and [Bmim]BF4 on acute toxicity, reactive oxygen species (ROS), antioxidant enzymes, glutathione S-transferase (GST), malondialdehyde (MDA), and DNA damage degree in livers of zebrafish were determined. The 50% lethal concentration (LC50) values after a 96-h exposure to [Bmim]Cl and [Bmim]BF4 were 632...
February 21, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28237757/preparation-and-characterization-of-an-antibacterial-ultrafiltration-membrane-with-n-chloramine-functional-groups
#6
Shuhua Hou, Xue Dong, Jianhua Zhu, Jifu Zheng, Weihui Bi, Shenghai Li, Suobo Zhang
In this study, a cardo poly(aryl ether ketone) ultrafiltration membrane containing an N-chloramine functional group (PEK-N-Cl membrane) was easily obtained via exposure of a cardo poly(aryl ether ketone) ultrafiltration membrane (PEK-NH membrane) to dilute sodium hypochlorite solution. The chlorination process did not harm membrane performance. In addition, the PEK-N-Cl membrane was stable in both air and water. The PEK-N-Cl membrane exhibited excellent antimicrobial properties against both Gram-negative and Gram-positive bacteria (i...
January 18, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28237756/the-retained-templates-as-helpers-for-the-spherical-meso-silica-in-adsorption-of-heavy-metals-and-impacts-of-solution-chemistry
#7
Zhijie Liang, Wenxin Shi, Zhiwei Zhao, Tianyi Sun, Fuyi Cui
The spherical mesoporous silica (meso-silica) MCM-41 and those with different dosage of the retained templates were prepared and characterized. Particularly, effects of the retained template and its dosage on the adsorption of typical heavy metals (Cu(2+) and Cd(2+)) in the synthesized materials were investigated. The results indicated that the retained templates acted as "helpers" for the adsorption of Cu(2+) and Cd(2+) in the spherical meso-silica MCM-41, and the maximum adsorption capacities (Qmax) increased with the increase of the retained template dosage...
February 12, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28237341/onset-of-luteolytic-action-of-exogenous-prostaglandinf-2%C3%AE-during-estrous-cycle-in-goats
#8
Juan E Romano, Abdalhamid Alkar, Marcel Amstalden
The objectives of these two experiments were to determine the day of onset of luteolysis after exogenous PGF-2α administration during the estrous cycle and the fertility of this synchronized estrus in goats. In the first experiment, during the breeding season, 48 Nubian does were estrous synchronized, using intravaginal sponges impregnated with a progestin, and estrus was detected by vasectomized bucks. The does were divided at random into three groups of 16 does each to be treated at days 2, 3, and 4 of the estrous cycle (estrus = day 0)...
April 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28236787/apigenin-7-o-glucoside-oxidation-catalyzed-by-p450-bioinspired-systems
#9
Lucas B Bolzon, Joicy S Dos Santos, Denise B Silva, Eduardo J Crevelin, Luiz A B Moraes, Norberto P Lopes, Marilda D Assis
Apigenin-7-O-glucoside (A7G) is the main flavonoid of Bidens gardneri Bak., a Brazilian plant with wide application in folk medicine. Despite the popular use of this plant, its biological effects are not completely known. This work tested the 5,10,15,20-tetrakis(pentafluorophenyl)porphyrin iron(III) and manganese(III) chloride (Fe(TFPP)Cl and Mn(TFPP)Cl), and Jacobsen's catalyst as P450-bioinspired catalysts for A7G oxidation by different oxidants (PhIO, H2O2, m-CPBA, and t-BuOOH). Up to nine different products were detected by HPLC analysis; Reactions with metalloporphyrin/PhIO systems afforded high catalytic conversions (58-89%)...
February 20, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28236407/comparative-pharmacokinetics-of-bergenin-a-main-active-constituent-of-saxifraga-stolonifera-curt-in-normal-and-hepatic-injury-rats-after-oral-administration
#10
Rong-Hua Pan, Hong-Mei He, Yue Dai, Yu-Feng Xia
Bergenin, isolated from the herb of Saxifrage stolonifera Curt. (Hu-Er-Cao) has hepatoprotective, anti-inflammatory, antitussive, and neuroprotective activities. The aim of the present study was to establish a simple, rapid, and sensitive RP-HPLC method for determination of bergenin in rat plasma and compare its oral pharmacokinetic behaviors in normal and CCl4-induced hepatic injury rats. With norisoboldine as an internal standard, chromatographic separation was performed on a C18 analytical column with acetonitrile and water (11 : 89, V/V) containing 0...
October 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28236149/hydrochemical-characterization-and-pollution-assessment-of-groundwater-in-jammu-siwaliks-india
#11
Shakil A Romshoo, Reyaz Ahmad Dar, Khalid Omar Murtaza, Irfan Rashid, Farooq A Dar
Physico-chemical groundwater (GW) parameters were evaluated to understand the hydrogeochemical processes in the Siwalik plains of Jammu and Kashmir, India. During the 2012-2013 post-monsoon (POM) and pre-monsoon (PRM) seasons, GW samples (n = 207) from deep bore wells and shallow open wells were chemically analysed. Cations (Ca(2+), Mg(2+), Na(+), K(+) and Fe(2+)) and anions (HCO3(-), Cl(-), SO4(2-) and F(-)) showed a wide spatio-temporal variation. Results suggest that weathering and dissolution of carbonates and silicate rocks is the main source of water mineralization...
March 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28235805/a-kainate-receptor-subunit-promotes-the-recycling-of-the-neuron-specific-k-cl-cotransporter-kcc2-in-hippocampal-neurons
#12
Jessica C Pressey, Vivek Mahadevan, C Sahara Khademullah, Zahra Dargaei, Jonah Chevrier, Alamjeet K Chauhan, Steven J Meas, Pavel Uvarov, Matti S Airaksinen, Melanie A Woodin
Synaptic inhibition depends on a transmembrane gradient of chloride, which is set by the neuron-specific K+-Cl- cotransporter KCC2. Reduced KCC2 levels in the neuronal membrane contribute to the generation of epilepsy, neuropathic pain, and autism spectrum disorders; thus, it is important to characterize the mechanisms regulating KCC2 expression. In the present study, we determined the role of KCC2-protein interactions in regulating total and surface-membrane KCC2 expression. Using quantitative immunofluorescence in cultured mouse hippocampal neurons, we discovered that the kainate receptor subunit GluK2 and the auxiliary subunit Neto2 significantly increase the total KCC2 abundance in neurons, but that GluK2 exclusively increases the abundance of KCC2 in the surface membrane...
February 24, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28231432/dismantling-the-red-wall-of-colloidal-perovskites-highly-luminescent-formamidinium-and-formamidinium-cesium-lead-iodide-nanocrystals
#13
Loredana Protesescu, Sergii Yakunin, Sudhir Kumar, Janine Bär, Federica Bertolotti, Norberto Masciocchi, Antonietta Guagliardi, Matthias Grotevent, Ivan Shorubalko, Maryna I Bodnarchuk, Chih-Jen Shih, Maksym V Kovalenko
Colloidal nanocrystals (NCs) of APbX3-type lead halide perovskites [A=Cs+, CH3NH3+ (methylammonium or MA+) or CH(NH2)2+ (formamidinium or FA+); X=Cl-, Br-, I-] have recently emerged as highly versatile photonic sources for applications ranging from simple photoluminescence down-conversion (e.g., for display backlighting) to light emitting diodes. From the perspective of spectral coverage, a formidable challenge facing the use of these materials is how to obtain stable emissions in the red and infrared spectral regions covered by the iodide-based compositions...
February 23, 2017: ACS Nano
https://www.readbyqxmd.com/read/28230756/synthesis-and-structural-evaluation-of-organo-ruthenium-complexes-with-%C3%AE-diketonates
#14
Matija Uršič, Tanja Lipec, Anton Meden, Iztok Turel
Four novel ruthenium organometallic complexes: [(η⁶-p-cymene)Ru(4,4,4-trifluoro-1-(4-bromophenyl)-1,3-butanedione)Cl] (1), [(η⁶-p-cymene)Ru(4,4,4-trifluoro-1-(4-bromophenyl)-1,3-butanedione)pta]PF₆ (2), [(η⁶-p-cymene)Ru(4,4,4-trifluoro-1-(4-iodophenyl)-1,3-butanedione)Cl] (3) and [(η⁶-p-cymene)Ru(4,4,4-trifluoro-1-(4-iodophenyl)-1,3-butanedione)pta]PF₆ (4) were synthesized and characterized by elemental analysis, infrared (IR), UV-Vis, NMR and mass spectroscopy and single-crystal X-ray diffraction...
February 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28230755/three-chalconoids-and-a-pterocarpene-from-the-roots-of-tephrosia-aequilata
#15
Yoseph Atilaw, Sandra Duffy, Matthias Heydenreich, Lois Muiva-Mutisya, Vicky M Avery, Máté Erdélyi, Abiy Yenesew
In our search for new antiplasmodial agents, the CH₂Cl₂/CH₃OH (1:1) extract of the roots of Tephrosia aequilata was investigated, and observed to cause 100% mortality of the chloroquine-sensitive (3D7) strain of Plasmodium falciparum at a 10 mg/mL concentration. From this extract three new chalconoids, E-2',6'-dimethoxy-3',4'-(2'',2''-dimethyl)pyranoretrochalcone (1, aequichalcone A), Z-2',6'-dimethoxy-3',4'-(2'',2''-dimethyl)pyranoretrochalcone (2, aequichalcone B), 4''-ethoxy-3''-hydroxypraecansone B (3, aequichalcone C) and a new pterocarpene, 3,4:8,9-dimethylenedioxy-6a,11a-pterocarpene (4), along with seven known compounds were isolated...
February 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28230602/subcutaneous-c-shape-muscular-flap-for-correcting-the-depression-of-alar-base-in-affected-side-in-patients-with-unilateral-complete-cleft-lip-palate-during-primary-surgery
#16
Dandan Wu, Guomin Wang, Ningjuan Ouyang, Yuhen Lin, Yang Chen, Jiewen Dai
PURPOSE: The depression of alar base in affected side in patients with unilateral complete cleft lip/palate (CL/P) is one of common clinical features. In this study, the authors try to explore the effect of subcutaneous C shape muscular flap for correcting the depression of alar base in affected side in patients with unilateral complete CL/P during primary surgery. METHODS: A total of 30 patients with unilateral complete CL/P who received primary correction of the lip nose deformity were included in this study...
February 22, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28230290/a3-adenosine-receptor-agonist-inhibited-survival-of-breast-cancer-stem-cells-via-gli-1-and-erk1-2-pathway
#17
Seyyed Mehdi Jafari, Mojtaba Panjehpour, Mahmoud Aghaei, Hamid Reza Joshaghani, Seyed Ehsan Enderami
Numerous studies have demonstrated the role of A3 adenosine receptor (A3AR) and signaling pathways in the multiple aspects of the tumor. However, there is a little study about the function of A3AR in the biological processes of cancer stem cells (CSCs). CSCs have a critical role in the maintenance and survival of breast cancer. The aim of current study was to investigate the effect of A3AR agonist on breast cancer stem cells (BCSCs). XTT assay showed antiprolierative effect of A3AR agonist (Cl-IB-MECA) on BCSCs...
February 23, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28230269/antigenic-burden-and-serum-igg-concentrations-influence-rituximab-pharmacokinetics-in-rheumatoid-arthritis-patients
#18
Bertrand Lioger, Soujanya Ratna Edupuganti, Denis Mulleman, Christophe Passot, Céline Desvignes, Théodora Bejan-Angoulvant, Gilles Thibault, Valérie Gouilleux-Gruart, Julien Mélet, Gilles Paintaud, David Ternant
AIMS: Rituximab is a monoclonal antibody directed against CD20, which is approved in rheumatoid arthritis (RA). This study aimed at assessing the influence of CD19+ cell counts as target-antigen amount, and of immunoglobulin G (IgG) serum concentrations on rituximab pharmacokinetics in RA patients. METHODS: In a cohort of 64 RA patients who had received repetitive courses of rituximab, the influence of CD19+ cell count, IgG serum concentration, body surface area (BSA), sex, and disease activity score in 28 joints (DAS28) on rituximab pharmacokinetic parameters was assessed using a population pharmacokinetic analysis...
February 23, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28229367/inhibition-of-mtor-pathway-by-rapamycin-decreases-p-glycoprotein-expression-and-spontaneous-seizures-in-pharmacoresistant-epilepsy
#19
Xiaosa Chi, Cheng Huang, Rui Li, Wei Wang, Mengqian Wu, Jinmei Li, Dong Zhou
The mammalian target of rapamycin (mTOR) has been demonstrated to mediate multidrug resistance in various tumors by inducing P-glycoprotein (P-gp) overexpression. Here, we investigated the correlation between the mTOR pathway and P-gp expression in pharmacoresistant epilepsy. Temporal cortex specimens were obtained from patients with refractory mesial temporal lobe epilepsy (mTLE) and age-matched controls who underwent surgeries at West China Hospital of Sichuan University between June 2014 and May 2015. We established a rat model of epilepsy kindled by coriaria lactone (CL) and screened pharmacoresistant rats (non-responders) using phenytoin...
February 22, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28229153/calculations-of-current-densities-for-neutral-and-doubly-charged-persubstituted-benzenes-using-effective-core-potentials
#20
Markus Rauhalahti, Stefan Taubert, Dage Sundholm, Vincent Liégeois
Magnetically induced current density susceptibilities and ring-current strengths have been calculated for neutral and doubly charged persubstituted benzenes C6X6 and C6X6(2+) with X = F, Cl, Br, I, At, SeH, SeMe, TeH, TeMe, and SbH2. The current densities have been calculated using the gauge-including magnetically induced current (GIMIC) method, which has been interfaced to the Gaussian electronic structure code rendering current density calculations using effective core potentials (ECP) feasible. Relativistic effects on the ring-current strengths have been assessed by employing ECP calculations of the current densities...
February 23, 2017: Physical Chemistry Chemical Physics: PCCP
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