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https://www.readbyqxmd.com/read/28230213/knock-in-human-fgfr3-achondroplasia-mutation-as-a-mouse-model-for-human-skeletal-dysplasia
#1
Yi-Ching Lee, I-Wen Song, Ya-Ju Pai, Sheng-De Chen, Yuan-Tsong Chen
Achondroplasia (ACH), the most common genetic dwarfism in human, is caused by a gain-of function mutation in fibroblast growth factor receptor 3 (FGFR3). Currently, there is no effective treatment for ACH. The development of an appropriate human-relevant model is important for testing potential therapeutic interventions before human clinical trials. Here, we have generated an ACH mouse model in which the endogenous mouse Fgfr3 gene was replaced with human FGFR3(G380R) (FGFR3(ACH)) cDNA, the most common mutation in human ACH...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28188850/immunolocalization-of-the-vesicular-acetylcholine-transporter-in-larval-and-adult-drosophila-neurons
#2
Sridhar Boppana, Natalie Kendall, Opeyemi Akinrinsola, Daniel White, Krushali Patel, Hakeem Lawal
Vesicular acetylcholine transporter (VAChT) function is essential for organismal survival, mediating the packaging of acetylcholine (ACh) for exocytotic release. However, its expression pattern in the Drosophila brain has not been fully elucidated. To investigate the localization of VAChT, we developed an antibody against the C terminal region of the protein and we show that this antibody recognizes a 65KDa protein corresponding to VAChT on an immunoblot in both Drosophila head homogenates and in Schneider 2 cells...
February 7, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/27988393/binary-combinations-of-organophosphorus-and-synthetic-pyrethroids-are-more-potent-acetylcholinesterase-inhibitors-than-organophosphorus-and-carbamate-mixtures-an-in-vitro-assessment
#3
COMPARATIVE STUDY
Sumitra Arora, Sahil Balotra, Gunjan Pandey, Anu Kumar
Anticholinesterase insecticides such as organophosphorous (OP) and carbamates pesticides (CB); and synthetic pyrethroids (SP) pesticides commonly co-occur in the environment. This raises the possibility of antagonistic, additive, or synergistic neurotoxicity in exposed organisms. Acetylcholinesterase (AChE) inhibition has been demonstrated to be useful as a biomarker for exposure to OP and CBs in many environments. This study investigated the response of housefly (Musca domestica) head AChE (HF-AChE) exposed to five OPs; chlorpyrifos (CPF), malathion (MLT), triazophos (TRZ), monocrotophos (MCP) and profenofos (PRF) and two CBs; carbaryl (CRB) and carbofuran (CBF) as individual compounds and as binary mixtures of OPs and CBs under in vitro conditions...
February 15, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/27922934/psychometric-properties-of-the-chinese-version-of-the-menopause-specific-quality-of-life-questionnaire
#4
Guangning Nie, Hongyan Yang, Jian Liu, ChunMei Zhao, Xiaoyun Wang
OBJECTIVE: The Menopause-Specific Quality-of-Life (MENQOL) questionnaire was developed as a specific tool to measure the health-related quality-of-life of postmenopausal women. Thus far, the Chinese version questionnaire has not been subjected to psychometric assessment with a large sample. This study aims to evaluate the validity and reliability of the Chinese version of the MENQOL specific to postmenopausal women in China. METHODS: A total of 1,137 menopausal symptomatic and 491 menopausal asymptomatic women from eight cities in China were recruited using a convenience sampling method...
December 5, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27826219/a-dengue-infection-without-bleeding-manifestations-in-an-adult-with-immune-thrombocytopenic-purpura
#5
N D B Ehelepola, M B K Gunawardhana, T N Sudusinghe, S K D Sooriyaarachchi, S P Manchanayake, K L R Kalupahana
BACKGROUND: Dengue is the most prevalent and fast spreading arboviral infection affecting people. No specific drug is available to treat dengue. Thrombocytopenia with potential of serious hemorrhages is one of the hall mark features of dengue. Immune thrombocytopenic purpura is an autoimmune disease causing thrombocytopenia. If a patient with that gets dengue, we expect severe thrombocytopenia with bleeding manifestations. Only a handful of such cases were reported before, and they were managed in different ways...
2016: Tropical Medicine and Health
https://www.readbyqxmd.com/read/27805337/tuberous-sclerosis-with-disseminated-malignancy
#6
Achintya S, Ragesh R, Neeraj Nischal, Manish Soneja, Aanchal Kakkar, Mehar C Sharma, Geethu Anthony, Surabhi Vyas, S K SharmaSenior Professor And Head Department Of Medicine All India Institute Of Medical Sciences Ansari Nagar New Delhi
Tuberous sclerosis is characterized by typical skin and clinical manifestations with predilection to neoplasia. We describe the case of a 42-year old female who presented with a mass and pain in right lumbar region with constitutional symptoms and generalized body aches since last one year. She had adenoma sebaceum, subungual fibromas and hepatomegaly. CT chest, abdomen and MRI revealed mass in the right renal fossa with wide spread extensions in the abdomen, left renal angiomyolipomas (AMLs) and intracerebral lesions...
November 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27730276/cholinesterases-in-gambusia-yucatana-biochemical-characterization-and-its-relationship-with-sex-and-total-length
#7
Gabriela Rodríguez-Fuentes, Valeria Marín-López, Esperanza Hernández-Márquez
Since several reports have indicated that cholinesterases (ChE) type and distribution is species specific and that in some species there is a relationship among gender, size and ChE activities, characterization has been suggested. The aim of the present study was to characterize the ChE present in head and muscle of Gambusia yucatana (using selective substrates and inhibitors) and to find its relationship with total length or gender. Results indicated that the ChE present in G. yucatana is an acetylcholinesterase (AChE) with high sensitivity to BW284C51 and an atypical smaller Km with butyrylthiocholine...
December 2016: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/27695567/anterior-cervical-discectomy-and-fusion-with-titanium-cages-for-simple-or-multilevel-herniated-discs-and-spur-of-the-cervical-spine-report-of-2-cases-and-experience-in-bali
#8
G B Mahadewa Tjokorda, Golden Nyoman, Maliawan Sri, Mizuno Junichi
This report presents two cases of cervicobrachialgia and radiculopathy due to multiple cervical herniated discs and spur formation that dealt with anterior cervical discectomy and fusion (ACDF) using different titanium interbody cages. The description of the clinical presentation, magnetic resonance imaging (MRI) appearances and management strategy are discussed. Both cases showed chronic neck pain and radiating pain from the shoulder to the arm. They had a history of blurry vision, cluster head ache, weakness, and numbness on the shoulder for 2 years...
October 2016: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/27614865/interaction-between-diabetes-mellitus-and-hypertension-on-risk-of-hearing-loss-in-highly-endogamous-population
#9
Abdulbari Bener, Abdulla O A A Al-Hamaq, Khalid Abdulhadi, Ahmed H Salahaldin, Loida Gansan
AIM: The aim of this study was to determine the prevalence of hearing loss and its association with type 2 diabetes mellitus (T2DM) in a highly endogamous population. DESIGN: This is a cross-sectional study. SETTING: The present study is carried out in Ear Nose Throat (ENT) and Endocrinology outpatient clinics of the Hamad General and Rumeilah Hospitals, Hamad Medical Corporation. SUBJECTS: All subjects aged between 20 and 59 years who visited the Endocrinology and ENT outpatient clinics of the Hamad Medical Corporation with hearing difficulty were included in this study during the period from January 2013 to July 2014...
September 5, 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/27597816/key-targets-for-multi-target-ligands-designed-to-combat-neurodegeneration
#10
REVIEW
Rona R Ramsay, Magdalena Majekova, Milagros Medina, Massimo Valoti
HIGHLIGHTS Compounds that interact with multiple targets but minimally with the cytochrome P450 system (CYP) address the many factors leading to neurodegeneration.Acetyl- and Butyryl-cholineEsterases (AChE, BChE) and Monoamine Oxidases A/B (MAO A, MAO B) are targets for Multi-Target Designed Ligands (MTDL).ASS234 is an irreversible inhibitor of MAO A >MAO B and has micromolar potency against the cholinesterases.ASS234 is a poor CYP substrate in human liver, yielding the depropargylated metabolite.SMe1EC2, a stobadine derivative, showed high radical scavenging property, in vitro and in vivo giving protection in head trauma and diabetic damage of endothelium...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27521226/involvement-of-cholinergic-and-purinergic-systems-during-the-inflammatory-response-caused-by-aeromonas-hydrophila-in-rhamdia-quelen
#11
Matheus D Baldissera, Carine F Souza, Pedro Henrique Doleski, Guerino B Júnior, Agueda C de Vargas, Bernardo Baldisserotto
The aim of this study was to evaluate the cholinergic (acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)) and purinergic (adenosine deaminase (ADA)) systems in head kidney, spleen, total blood and serum samples in experimentally infected fish with A. hydrophila, and the involvement of these systems during the inflammatory process. Silver catfish (Rhamdia quelen) juveniles were divided into two groups with seven fish each: uninfected (negative control) and infected (positive control). On day 2 post-infection, animals were euthanized and the head kidney, spleen, total blood and serum were collected...
October 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27497329/acute-restraint-stress-provokes-sudden-cardiac-death-in-normotensive-rats-and-enhances-susceptibility-to-arrhythmogenic-effects-of-adrenaline-in-spontaneously-hypertensive-rats
#12
Jinyao Liu, Ayako Hakucho, Xu Liu, Tatsuya Fujimiya
BACKGROUND: A high incidence of cardiovascular events and sudden cardiac death (SCD) has been reported following unexpected acute psychosocial stress. The possible pathways by which acute restraint stress (ARS), a kind of acute psychosocial stress, leads to SCD were determined. METHODS: Using 16-week-old male normotensive Wistar Kyoto rats (WKY, n=24) as controls and spontaneously hypertensive rats (SHR, n=24) as the hypertensive subjects with left ventricular hypertrophy (LVH), we assessed ARS-related incidence of SCD, cardiac and myocardial autonomic nervous system dysfunction, gap junction connexin-43 (Cx43) channel remodeling, and ventricular repolarization abnormality, based on electrocardiography, an adrenaline test, heart rate variability (HRV), and reverse transcriptase polymerase chain reaction analyses...
July 2016: Legal Medicine
https://www.readbyqxmd.com/read/27419095/antinociceptive-activity-of-euadenia-trifoliolata-schum-thonn-oliv-leaves-and-roots-in-mice
#13
Margaret O Sofidiya, Opeyemi M Oloruntola, Ikepo Sofola, Muyiwa S Fageyinbo
The leaves and roots of Euadenia trifoliolata are used in Nigeria traditional medicine for the treatment of ear ache, head ache and inflammation. The aim of the study was to evaluate the antinociceptive activity of ethanolic extract of the leaves (EL) and roots (ER) of E. trifoliolata in mice. Oral toxicity testing was performed using OECD guidelines. Antinociceptive effect was studied in mice using acetic acid-induced writhing, formalin, tail immersion and hot plate tests. Total polyphenolic contents were determined using standard methods...
July 2016: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/27274270/orbital-metastasis-as-the-initial-presentation-of-lung-adenocarcinoma-a-case-report
#14
Liangchao Sun, Yali Qi, Xindong Sun, Jinming Yu, Xue Meng
Orbital metastasis as the initial presentation of lung adenocarcinoma is very rare, and so the lack of knowledge about this phenomenon can easily result in misdiagnosis, either as a orbital primary tumor or benign lesion. Here, we report a rare case in which the orbital symptom appeared first without any pulmonary manifestations. Our patient developed decreasing vision in his right eye over a 3-month duration. He then presented with proptosis and multiple aches from head to back. After systemic evaluation, our patient was diagnosed with Stage IV non-small-cell lung cancer and was managed with palliative chemoradiotherapy...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27225139/effect-of-leadership-styles-on-job-satisfaction-among-critical-care-nurses-in-aseer-saudi-arabia
#15
Fawaz Musaed M Alshahrani, Lubna A Baig
OBJECTIVE: To evaluate the effect of transformational and transactional leadership styles of head nurses on the job satisfaction of staff nurses in critical care units (CCU) of a tertiary care hospital. STUDY DESIGN: Cross-sectional study. PLACE AND DURATION OF STUDY: Critical care units at Aseer Central Hospital (ACH), Abha, Saudi Arabia, from July to December 2012. METHODOLOGY: The multifactor leadership questionnaire (MLQ-5X) and job satisfaction survey with demographics were used...
May 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/27224742/varicella-zoster-virus-triggers-the-immunopathology-of-giant-cell-arteritis
#16
Don Gilden, Maria A Nagel
PURPOSE OF REVIEW: Giant cell arteritis (GCA) is a severe form of vasculitis in the elderly. The recent discovery of varicella zoster virus (VZV) in the temporal arteries and adjacent skeletal muscle of patients with GCA, and the rationale and strategy for antiviral and corticosteroid treatment for GCA are reviewed. RECENT FINDINGS: The clinical features of GCA include excruciating headache/head pain, often with scalp tenderness, a nodular temporal arteries and decreased temporal artery pulsations...
July 2016: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27122955/heart-attack-causes-head-ache-cardiac-cephalalgia
#17
Chi-Cheng Huang, Pen-Chih Liao
UNLABELLED: Chest pain is the typical symptom of myocardial infarction (MI), and there are many atypical manifestations such as stomachache or dyspnea. Headache is a rare presentation of MI, which has specifically been termed "cardiac cephalalgia" or "cardiac cephalgia". In this article, we have reported a case of sudden onset headache and neck pain, of whom MI was confirmed by electrocardiography, cardiac markers, and coronary angiogram. The patient's headache subsided dramatically after coronary angioplasty, and it had not recurred in the following one year...
March 2016: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/27082875/novel-stress-increases-hypothalamic-pituitary-adrenal-activity-in-mice-with-a-raised-bite
#18
Hidekazu Miyake, Daisuke Mori, Tasuku Katayama, Shuu Fujiwara, Yuichi Sato, Kagaku Azuma, Kin-Ya Kubo
BACKGROUND AND OBJECTIVE: In humans, occlusal disharmony may cause various physical complaints, including head and neck ache, stiffness in the shoulder and neck, and arthrosis of the temporomandibular joints. Occlusal disharmony induced by raising the bite in rodents, increases plasma corticosterone levels, which leads to morphologic changes in the hippocampus and altered hippocampus-related behavior. The paraventricular nucleus (PVN) of the hypothalamus regulates the hypothalamic-pituitary-adrenal system...
August 2016: Archives of Oral Biology
https://www.readbyqxmd.com/read/26997996/severity-and-prognosis-of-acute-organophosphorus-pesticide-poisoning-are-indicated-by-c-reactive-protein-and-copeptin-levels-and-apache-ii-score
#19
Xinkuan Wu, Wei Xie, Yuelei Cheng, Qinglong Guan
The aim of the present study was to investigate the plasma levels of C-reactive protein (CRP) and copeptin, in addition to the acute physiology and chronic health evaluation II (APACHE II) scores, in patients with acute organophosphorus pesticide poisoning (AOPP). A total of 100 patients with AOPP were included and divided into mild, moderate and severe groups according to AOPP diagnosis and classification standards. Blood samples were collected from all patients on days 1, 3 and 7 following AOPP. The concentrations of CRP and copeptin in the plasma were determined using enzyme-linked immunosorbent assay...
March 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/26824831/sublethal-toxicity-endpoints-of-heavy-metals-to-the-nematode-caenorhabditis-elegans
#20
Ying Jiang, Jiandong Chen, Yue Wu, Qiang Wang, Huixin Li
Caenorhabditis elegans, a free-living nematode, is commonly used as a model organism in ecotoxicological studies. The current literatures have provided useful insight into the relative sensitivity of several endpoints, but few direct comparisons of multiple endpoints under a common set of experimental conditions. The objective of this study was to determine appropriate sublethal endpoints to develop an ecotoxicity screening and monitoring system. C. elegans was applied to explore the sublethal toxicity of four heavy metals (copper, zinc, cadmium and chromium)...
2016: PloS One
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