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https://www.readbyqxmd.com/read/29758498/accumulation-elimination-and-neuro-oxidative-damage-under-lanthanum-exposure-in-glass-eels-anguilla-anguilla
#1
Cátia Figueiredo, Tiago F Grilo, Clara Lopes, Pedro Brito, Mário Diniz, Miguel Caetano, Rui Rosa, Joana Raimundo
Rare earth elements (REEs) comprise elements from lanthanum to lutetium that together with yttrium and scandium are emergent contaminants of critical importance for numerous groundbreaking environmental technologies. Transfer to aquatic ecosystems is expected to increase, however, little information is known about their potential impacts in marine biota. Considering the endangered conservation status of the European eel (Anguilla anguilla) and the vulnerability of early fish life stages to contaminants, we exposed glass eels, through water, to an environmentally relevant concentration (120 ng...
May 7, 2018: Chemosphere
https://www.readbyqxmd.com/read/29744622/lethal-and-sublethal-responses-in-the-fish-odontesthes-bonariensis-exposed-to-chlorpyrifos-alone-or-under-mixtures-with-endosulf%C3%A3-n-and-lambda-cyhalothrin
#2
Viviana López Aca, Patricia Verónica Gonzalez, Pedro Carriquiriborde
Need for ecotoxicological information on local species has been recently highlighted as a priority issue in Latin America. In addition, little information has been found on concentration distances between lethal and sublethal effects, and the effect of mixtures at these two levels of analysis. Chlorpyrifos (CPF) is an organophosphate insecticide broadly used in soybean crops which has dramatically expanded in Latin America and other regions of the world. The aim of the present study was to evaluate lethal and sublethal effects of CPF, singly or in mixtures, on the inland "Pejerrey" (Odontesthes bonariensis) under laboratory conditions...
May 9, 2018: Ecotoxicology
https://www.readbyqxmd.com/read/29682018/modern-microsurgical-resection-of-olfactory-groove-meningiomas-by-classical-bicoronal-subfrontal-approach-without-orbital-osteotomies
#3
Ghulam Farooq, Lal Rehman, Irum Bokhari, Syed Raza Hussain Rizvi
Background: The olfactory groove meningioma has always been surgically challenging. The common microscopic surgical procedures exercised involve modification of pterional or sub-frontal approaches with or without orbital osteotomies. However, we believe that orbital osteotomies are not mandatory to achieve gross total resection. Hence, this study was performed to evaluate the surgical outcomes of olfactory groove meningioma with bicoronal sub frontal approach but without orbital osteotomies...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29677280/assessment-of-the-effectiveness-of-combat-eyewear-protection-against-blast-overpressure
#4
A Sundaramurthy, M Skotak, E Alay, G Unnikrishnan, H Mao, X Duan, S T Williams, T H Harding, N Chandra, J Reifman
It is unclear whether combat eyewear used by U. S. Service members is protective against blast overpressures (BOPs) caused by explosive devices. Here, we investigated the mechanisms by which BOP bypasses eyewear and increases eye surface pressure. We performed experiments and developed three-dimensional (3D) finite element (FE) models of a head form (HF) equipped with an advanced combat helmet (ACH) and with no eyewear, spectacles, or goggles in a shock tube at three BOPs and five head orientations relative to the blast wave...
July 1, 2018: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29662890/harsh-working-conditions-and-poor-eating-habits-health-related-concerns-of-female-head-porters-kayayei-in-the-mallam-atta-market-accra-ghana
#5
Samuel Harrenson Nyarko, Abdul Majeed Tahiru
Background: The kaya business is known to pose significant health-related risks to female migrants. This study sought to explore the health-related concerns of female head porters in the Mallam Atta market, Accra, Ghana. Methods: A qualitative study was conducted in which twenty female head porters at the Mallam Atta market in Accra were interviewed. A thematic analysis was performed and the emerging themes were presented and supported with quotations from the respondents...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29540210/a-vegetable-induced-hemolytic-crisis-in-a-g6pd-deficient-person-a-case-report
#6
N D B Ehelepola, A N Abayagunawardana, T N Sudusinghe
BACKGROUND: Hemolysis can occur in people with G6PD deficiency under oxidative stress. Acalypha indica is a tropical plant used as a medicinal plant as well as a vegetable. There are a few reported cases of Acalypha indica ingestion induced hemolysis in G6PD deficient people. All except one of them are from Sri Lanka. The information available at present (2017) about G6PD deficiency prevalence and variants of the G6PD gene among Sri Lankans is very sparse. There are no past reports on hemolytic crisis in a G6PD deficient person presenting mimicking leptospirosis...
March 14, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29408046/maleimide-acetylcholine-headed-bolaamphiphilic-vesicles-made-from-ricinoleic-acid-prospective-active-targeted-drug-delivery-systems
#7
Monique B Ewonkem, Sarina Grinberg
Based on ricinoleic acid, two asymmetric bolaamphiphiles with unsymmetrical hydrophobic skeletons and two different hydrophilic head groups were designed and synthesized. The first bola compound had acetylcholine (ACh) and maleimide (MAL) head groups while the second was derived from the first bolaamphiphile by thiol-ene conjugation of its maleimide moiety with l-glutathione and possessed ACh and l-glutathione-MAL head groups. Both synthetic bolaamphiphiles were characterized by common spectroscopic methods...
February 2, 2018: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/29276203/-all-the-world-is-gone-to-the-assembly-elizabeth-carter-s-headaches-nerves-and-in-sociability
#8
Mascha Hansen
Elizabeth Carter suffered from severe headaches all her life. Her letters are peppered with references to fits of "head-ach" so bad they made her bold enough to demand her own room wherever she visited, and to cherish a preference for solitude contrary to the ideal of Bluestocking sociability. Following her friends and physicians, she bowed to fashionable diagnoses in considering these headaches the result of a nervous constitution, and she was prescribed the usual remedies, including sociable trips to fashionable watering places...
2017: Literature and Medicine
https://www.readbyqxmd.com/read/29258877/different-response-of-acetylcholinesterases-in-salt-and-detergent-soluble-fractions-of-honeybee-haemolymph-head-and-thorax-after-exposure-to-diazinon
#9
Gordana Glavan, Monika Kos, Janko Božič, Damjana Drobne, Jerica Sabotič, Anita Jemec Kokalj
Organophosphate pesticide diazinon is a specific inhibitor of acetylcholinesterase (AChE), which is a common neurotoxicity biomarker in environmental studies. In honeybees, AChE exists in two forms having different physiological roles, one existing as a soluble form and the other as membrane-bound. In most studies AChE activity has been analysed without paying considerable attention to different forms of AChE. In this study, we exposed honeybees Apis mellifera carnica for 10days to diazinon via oral exposure and analysed the total AChE activities in salt soluble (SS) and detergent soluble (DS) fractions...
February 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29233238/neck-kinematics-and-electromyography-while-wearing-head-supported-mass-during-running
#10
Matthew M Hanks, JoEllen M Sefton, Gretchen D Oliver
BACKGROUND: Advanced combat helmets (ACH) coupled with night-vision goggles (NVG) are required for tactical athletes during training and service. Head and neck injuries due to head supported mass (HSM) are a common occurrence in military personnel. The current study aimed to investigate the effects of HSM on neck muscle fatigue that may lead to chronic stress and injury of the head and neck. METHODS: Subjects wore an ACH and were affixed with electromagnetic sensors to obtain kinematic data, as well as EMG electrodes to obtain muscle activations of bilateral sternocleidomastoid, upper trapezius, and paraspinal muscles while running on a treadmill...
January 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29191452/hesperidin-attenuates-iron-induced-oxidative-damage-and-dopamine-depletion-in-drosophila-melanogaster-model-of-parkinson-s-disease
#11
Márcia Rósula Poetini, Stífani Machado Araujo, Mariane Trindade de Paula, Vandreza Cardoso Bortolotto, Luana Barreto Meichtry, Francielli Polet de Almeida, Cristiano Ricardo Jesse, Simone Noremberg Kunz, Marina Prigol
This study has evaluated the action of flavonoid hesperidin on the neurotoxic effects caused by the intake of iron (Fe) in Drosophila melanogaster. Male adult flies, aged 1-3 days, have been divided into four groups of 50 each: (1) control, (2) Hsd 10 μM, (3) Fe 20 mM (4) Hsd 10 μM + Fe 20 mM. During the exposure protocol, the flies have been exposed to a diet containing Hsd and/or Fe for 48 h. The survival and behavioral analyses have been carried out in vivo, and ex vivo. The analyses involved acetylcholinesterase (AChE) activity and Fe levels in the flies' heads and bodies and determination of dopaminergic levels, cellular and mitochondrial viability, activities of superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), reactive species levels (RS), thiobarbituric acid reactive substances (TBARS) and contents of total thiols and non-proteic thiols (NPSH) in the flies' heads...
January 5, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29031972/selective-two-dimensional-effect-directed-analysis-with-thin-layer-chromatography
#12
Lena Stütz, Stefan C Weiss, Wolfgang Schulz, Wolfgang Schwack, Rudi Winzenbacher
There are thousands of organic trace substances in the environment that are not fully characterized, and evaluation of their relevance to the ecosystem is difficult. Effect-directed analysis (EDA) is a suitable tool to assess the effects of a substance via in-vitro bioassays, which can provide information about the relevance of the substance. High-performance thin-layer chromatography (HPTLC) has been shown to be a good method for fractionation. Environmental samples, however, often have high complexity, which is why the peak capacity of HPTLC is not sufficient...
November 17, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28994023/treatment-with-pentylenetetrazole-ptz-and-4-aminopyridine-4-ap-differently-affects-survival-locomotor-activity-and-biochemical-markers-in-drosophila-melanogaster
#13
Deividi C S Soares, José L R Portela, Daniel H Roos, Nathane R Rodrigues, Karen K Gomes, Giulianna E Macedo, Thais Posser, Jeferson L Franco, Waseem Hassan, Robson L Puntel
PTZ is a convulsive agent that acts via selective blockage of GABAA receptor channels, whereas 4-AP leads to a convulsive episode via blockage of K+ channels. However, the mechanism(s) by which pentylenetetrazole (PTZ) and 4-aminopyridine (4-AP) cause toxicity to Drosophila melanogaster needs to be properly explored, once it will help in establishing an alternative model for development of proper therapeutic strategies and also to counteract the changes associated with exposure to both epileptic drugs. For the purpose, we investigated the effects of exposure (48 h) to PTZ (60 mM) and/or 4-AP (20 mM) on survival, locomotor performance, and biochemical markers in the body and/or head of flies...
May 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28972699/ledipasvir-and-sofosbuvir-for-untreated-hcv-genotype-1-infection-in-end-stage-renal-disease-patients-a-prospective-observational-study
#14
Mandarapu Surendra, Sree Bhushan Raju, Nimmagadda Sridhar, Bangillapati Vijay Kiran, Goli Rajesh, Golla Anvesh, Nallagasu Raju
INTRODUCTION: Hepatitis C virus (HCV) infection in end stage renal disease (ESRD) is associated with increased mortality. Recently, numerous directly acting antiviral agents have been approved for the management of HCV. Ledipasvir along with Sofosbuvir has been approved for management of genotype 1 infection in patients with eGFR ≥30 mL/min. However, there is paucity of data regarding its role in the management of patients on dialysis. MATERIAL AND METHODS: This is a single center prospective open label observational study to assess the safety and efficacy of Ledipasvir and Sofosbuvir in hemodialysis (HD) patients who were diagnosed with HCV genotype 1 infection...
October 3, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28805272/clinical-phenotype-of-south-east-asian-temporomandibular-disorder-patients-with-upper-airway-resistance-syndrome
#15
D K L Tay, K P Pang
Clinical and radiographic characteristics of a subset of South East Asian temporomandibular disorder (TMD) patients with comorbid upper airway resistance syndrome (UARS) were documented in a multi-center prospective series of 86 patients (26 men and 60 women / mean age 35.7 years). All had excessive daytime sleepiness, high arousal index and Apnoea-Hypopnoea Index (AHI) <5. The mean body mass index was 20·1, mean arousal index 16·2, mean respiratory disturbance index 19·6, mean AHI 3·9 while the mean Epworth Sleepiness Scale was 14·8...
January 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28793400/enhanced-uptake-of-bpa-in-the-presence-of-nanoplastics-can-lead-to-neurotoxic-effects-in-adult-zebrafish
#16
Qiqing Chen, Daqiang Yin, Yunlu Jia, Sabrina Schiwy, Jessica Legradi, Shouye Yang, Henner Hollert
Plastic particles have been proven to be abundant in the aquatic environment, raising concerns about their potential toxic effects. In the present study, we determined the bioaccumulation potential of bisphenol A (BPA) in adult zebrafish (Danio rerio) in the absence and presence of nano-sized plastic particles (nanoplastics, NPPs). Results show that BPA can accumulate in the viscera, gill, head and muscle of zebrafish with 85, 43, 20, and 3μg/g ww after 1d exposure. NPPs were also found to accumulate in different tissues of the fish...
December 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28694460/two-bombyx-mori-acetylcholinesterase-genes-influence-motor-control-and-development-in-different-ways
#17
Xinhai Ye, Liwen Yang, David Stanley, Fei Li, Qi Fang
Among its other biological roles, acetylcholinesterase (AChE, EC 3.1.1.7), encoded by two ace in most insects, catalyses the breakdown of acetylcholine, thereby terminating synaptic transmission. ace1 encodes the synaptic enzyme and ace2 has other essential actions in many insect species, such as Chilo suppressalis and Plutella xylostella. The silkworm, Bombyx mori, has been domesticated for more than two thousand years and its aces have no history of pesticide exposure. Here, we investigated the functional differences between two ace genes, BmAce1 and BmAce2, in the silkworm...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28672421/-acute-coronary-syndrome-what-should-the-general-practitioner-do
#18
REVIEW
Stefan Stadler, Dierk Endemann, Lars S Maier
Acute myocardial infarction is the second most common cause of mortality in Germany after chronic ischemic cardiac disease. It is essential to think of acute coronary syndrome also in patients who do not present with typical signs (pressure, tightness, pain, or a squeezing or aching sensation in the chest or arms that may spread to the neck, jaw or back) in the general practitioner's practice. Vital signs (blood pressure, heart rate and oxygen saturation) must be measured; an ECG should be recorded and analyzed within ten minutes of first medical contact...
July 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28630843/osteosarcoma-of-jaw-with-varying-histomorphologic-patterns-case-report
#19
Ruchika Ravi Agrawal, Jyoti Dilip Bhavthankar, Mandakini Subhash Mandale, Purva Prakash Patil
INTRODUCTION: Osteosarcoma is a malignant mesenchymal tumor whose cancerous cells produce osteoid matrix. It is a common primary malignant bone tumor, representing 23% of total head and neck malignancies. Osteosarcomas of the jaws are rare lesions, representing only 4-7% of all osteosarcomas. This presentation discusses the clinical, radiographical, and histopathological features of a case of osteosarcoma of the mandible with unusual histopathological appearance. CASE REPORT: A 21-year-old male patient reported with a diffuse swelling of the right side of mandible with dull ache and increasing difficulties with eating and speech...
January 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28288576/prodromal-symptoms-health-care-seeking-in-response-to-symptoms-and-associated-factors-in-eclamptic-patients
#20
Wondimu Gudu
BACKGROUND: Eclampsia is one of the leading causes of maternal death worldwide. Maternal catastrophe is made worse in developing countries by the high incidence coupled with delayed presentation of patients and health facility constraints in effective management of eclampsia and its complications. METHODS: A prospective study of all 93 eclamptic women admitted to a general hospital in Somali regional state, Ethiopia was conducted between May 1, 2014 and April 30, 2015 using a structured questionnaire which included socio-demographic data, antenatal visit status, distance of nearest maternal health facility, timing of convulsions, questions related to symptoms preceding seizures; health care seeking for the symptoms and time interval from prodromal symptoms to the diagnosis of eclampsia...
March 14, 2017: BMC Pregnancy and Childbirth
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