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https://www.readbyqxmd.com/read/29922085/the-effect-of-passive-leg-raising-maneuver-on-hemodynamic-stability-during-anesthesia-induction-for-adult-cardiac-surgery
#1
Solmaz Fakhari, Eissa Bilehjani, Haleh Farzin, Hojjat Pourfathi, Mohsen Chalabianlou
Introduction: Some cardiac patients do not tolerate the intravenous fluid load commonly administered before anesthesia induction. This study investigated preinduction passive leg-raising maneuver (PLRM) as an alternative method to fluid loading before cardiac anesthesia. Methods and materials: During a 6-month period, 120 adult elective heart surgery patients were enrolled in this study and allocated into 2 groups: PLRM group vs control group (n=60). Anesthesia was induced using midazolam, fentanyl, and cisatracurium...
2018: Integrated Blood Pressure Control
https://www.readbyqxmd.com/read/29921087/negative-association-between-previous-allergy-and-intradermal-tests-for-rocuronium-and-cisatracurium-what-about-additional-tests
#2
Nicholas G Kounis, Ioanna Koniari, Emmanouil Chourdakis, Periklis Davlouros, George Hahalis
No abstract text is available yet for this article.
June 20, 2018: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/29900767/anesthesia-of-aquarium-housed-walrus-odobenus-rosmarus-a-case-series
#3
Johanna Kaartinen, Stéphane Lair, Michael T Walsh, Patrick Burns, Marion Desmarchelier, Jessica M Pang, Daniel S J Pang
  Walruses are a challenging species to anesthetize as a result of their large mass, limited access for drug delivery, unique physiology, and small number of reports describing anesthetic procedures. Three aquarium-housed walruses ( Odobenus rosmarus) ranging in age from 3 to 11 yr old (344-1,000 kg) were anesthetized for dental or ophthalmic surgical procedures, with one animal anesthetized twice and one anesthetized three times. Preanesthetic medication was with intramuscular midazolam (0.1-0.2 mg/kg) and meperidine (2-3 mg/kg)...
June 2018: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/29805180/acyclic-cucurbit-n-uril-type-receptors-preparation-molecular-recognition-properties-and-biological-applications
#4
Shweta Ganapati, Lyle Isaacs
This article traces the development of acyclic cucurbit[n]uril-type receptors with a focus on work from the Isaacs group. First, we describe the synthesis of methylene bridged glycoluril dimers capped with aromatic sidewalls which allowed us to probe the interconversion of the S- and C-shaped dimers which is a fundamental step in CB[n] formation. The C-shaped compounds were found to undergo discrete self-assembly (dimerization) in both water and organic solvents which lead us to investigate multicomponent self-sorting systems...
April 2018: Israel Journal of Chemistry
https://www.readbyqxmd.com/read/29725382/effects-of-cisatracurium-in-combination-with-ventilation-on-inflammatory-factors-and-immune-variations-in-sepsis-rats
#5
Tongyun He, Jianmei Tao, Xinqiang Wang, Xuena Wang
The effects of cisatracurium in combination with ventilation on inflammatory factors and immune variations in sepsis rats were investigated. A total of 54 male Sprague-Dawley rats were selected and divided randomly into three groups: Sham group (n=6), model group (n=24) and experiment group (n=24). Rats in the model and experiment groups underwent cecal ligation and puncture (CLP) for establishment of sepsis model. Rats in experiment group additionally received cisatracurium medication in combination with ventilation for treatment...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29696129/controlled-hypotension-during-rhinoplasty-a-comparison-of-dexmedetomidine-with-magnesium-sulfate
#6
Faranak Rokhtabnak, Soudabeh Djalali Motlagh, Mohamadreza Ghodraty, Alireza Pournajafian, Mojtaba Maleki Delarestaghi, Arash Tehrani Banihashemi, Zeinab Araghi
Objective: The current study aimed at comparing the efficacy of dexmedetomidine and magnesium sulfate to control blood pressure (BP) during rhinoplasty and the resultant effects on the quality of surgical field in terms of bleeding and visibility. Methods: The current randomized, prospective, double-blind study was conducted on 60 patients aged 18 to 50 years classified as ASA (American Society of Anesthesiologists) physical status I who were candidates for rhinoplasty...
December 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/29684989/intradermal-skin-tests-for-rocuronium-and-cisatracurium-in-patients-with-a-history-of-allergy-a-retrospective-study
#7
Yu Yil Kim, Ik Thae Kim, Sung In Shin, So Mang Yim
Background: Neuromuscular blocking agents (NMBAs) are a leading cause of perioperative anaphylaxis. However, the performance of systematic screening skin tests to detect reactions for NMBAs prior to general anesthesia is not recommended. We retrospectively examined intradermal tests (IDTs) for rocuronium and cisatracurium in patients with a history of allergy. Methods: We reviewed the records of patients who underwent IDTs for NMBAs between January 1 and December 31, 2016...
April 24, 2018: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/29652752/practice-change-from-intermittent-medication-boluses-to-bolusing-from-a-continuous-infusion-in-pediatric-critical-care-a-quality-improvement-project
#8
Jessica L Hochstetler, A Jill Thompson, Natalie M Ball, Melissa C Evans, Shaun C Frame, A Lauren Haney, Amelia K Little, Jaime L O'Donnell, Bryna M Rickett, Elizabeth H Mack
OBJECTIVES: To determine whether implementing a guideline to bolus medications from continuous infusions in PICUs affects nursing satisfaction, patient safety, central line entries, medication utilization, or cost. DESIGN: This is a pre- and postimplementation quality improvement study. SETTING: An 11-bed ICU and 14-bed cardiac ICU in a university-affiliated children's hospital. PATIENTS: Patients less than 18 years old admitted to the PICU or pediatric cardiac ICU receiving a continuous infusion of dexmedetomidine, midazolam, fentanyl, morphine, vecuronium, or cisatracurium from May 2015 to May 2016, excluding November 2015 (washout period), were eligible for inclusion...
June 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29624542/effects-of-combined-lower-thoracic-epidural-general-anesthesia-on-pain-control-in-patients-undergoing-elective-lumbar-spine-surgery-a-randomized-controlled-trial
#9
Marvin Thepsoparn, Jariya Sereeyotin, Patt Pannangpetch
STUDY DESIGN: Randomized controlled trial. OBJECTIVE: Our objective was to compare postoperative pain relief and operating field condition of single shot low thoracic epidural anesthesia combined with general anesthesia versus general anesthesia alone. SUMMARY OF BACKGROUND DATA: Prior studies have suggested that continuous epidural analgesia provides better postoperative pain relief and less intraoperative blood loss, but with the risk of the epidural catheter contaminating the surgical field...
April 5, 2018: Spine
https://www.readbyqxmd.com/read/29584526/corrected-qt-interval-prolongation-during-anesthetic-induction-for-laryngeal-mask-airway-insertion-with-or-without-cisatracurium
#10
Chengluan Xuan, Nan Wu, Yanhui Li, Xiaoting Sun, Qunshu Zhang, Haichun Ma
Objective This study was performed to observe the occurrence of corrected QT (QTc) interval prolongation during anesthetic induction for laryngeal mask airway insertion and the effects of cisatracurium administration on the QTc interval. Methods Eighty-eight patients were assigned to two groups: the cisatracurium administration group (n = 45) and non-cisatracurium administration group (n = 43). The QTc interval was continuously recorded by a 12-lead Holter electrocardiogram beginning in the hospital ward and continuing until after anesthetic induction...
May 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29517695/optimal-dose-of-combined-rocuronium-and-cisatracurium-during-minor-surgery-a-randomized-trial
#11
RANDOMIZED CONTROLLED TRIAL
Woo Young Park, Jae Chan Choi, Hey Jeong Yun, Yeong Gwan Jeon, Gisoon Park, Jong Bum Choi
BACKGROUND: Combined rocuronium and cisatracurium have synergistic effects. We investigated whether reduced doses are effective during coadministration, by monitoring neuromuscular relaxation during surgery. METHODS: This randomized, controlled clinical trial was registered at http://clinicaltrials.gov (registration number NCT02495038). The participants were 81 patients scheduled for elective mastoidectomy and tympanoplasty. Participants were assigned to groups, including the intubating dose group (Group I, n = 27; combined ED95 rocuronium and ED95 cisatracurium), the small reduction group (Group S, n = 27; dose reduced by 10% of each ED95), or the large reduction group (Group L, n = 27; dose reduced by 20% of each ED95)...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29327523/association-of-physicians-of-india-position-statement-on-role-of-chirally-pure-molecules-in-clinical-practice
#12
Milind Y Nadkar, Mangesh Tiwaskar, Sanjay Kalra, Siddharth N Shah, B R Bansode, Anjanlal Dutta, Sarita Bajaj, Sameer Aggarwal, Yatan Pal Singh Balhara, A K Das, Puneet Dhamija, Y K Gupta, Jubbin Jacob, Sundeep Mishra, S N Narasingan, C K Ponde, Ram Prabhoo, Balakrishnan S, Manisha Sahay, R K Sahay, I Sathyamurthy, Shilpa Tiwaskar, Agam Vora
Chirally pure molecules or enantiomers are non-superimposable mirror images of each other with a chiral center (such as carbon, sulphur, nitrogen or phosphorous atom). An equimolar mixture of enantiomers forms a racemate. Chirally pure molecules (single enantiomers) are important in the field of drug discovery as the drug targets such as enzymes and receptors are enantioselective in nature. Clinical studies have demonstrated that chirally pure drugs exhibit different pharmacokinetic and metabolic profiles, reduced adverse events, improved safety profiles and similar therapeutic activity at lowered drug dosage as compared with the racemate in many therapeutic areas...
December 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29324189/is-cisatracurium-the-neuromuscular-blocking-agent-of-choice-in-acute-respiratory-distress-syndrome
#13
David T Huang, Laurent Papazian
No abstract text is available yet for this article.
April 1, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29241014/an-observational-study-of-the-efficacy-of-cisatracurium-compared-with-vecuronium-in-patients-with-or-at-risk-for-acute-respiratory-distress-syndrome
#14
Peter D Sottile, Tyree H Kiser, Ellen L Burnham, P Michael Ho, Richard R Allen, R William Vandivier, Marc Moss
RATIONALE: The neuromuscular blocking agent cisatracurium may improve mortality for patients with moderate-to-severe acute respiratory distress syndrome (ARDS). Other neuromuscular blocking agents, such as vecuronium, are commonly used and have different mechanisms of action, side effects, cost, and availability in the setting of drug shortages. OBJECTIVES: To determine whether cisatracurium is associated with improved outcomes when compared with vecuronium in patients at risk for and with ARDS...
April 1, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29210718/successful-treatment-of-idiopathic-intractable-hiccup-with-cisatracurium-under-intravenous-general-anesthesia-a-case-report
#15
Jian-Ping Wu, Jian-Xiong An, Xiao-Yan Qian, Yong Wang
We report the successful treatment of idiopathic intractable hiccups with cisatracurium under intravenous general anesthesia. The patient had a history of hiccups for 19 years that were refractory to a variety of treatments. When his hiccups were accompanied by vomiting, insomnia, shortness of breath, and poor oral intake for 9 days, he sought relief. We administered a nondepolarizing muscle relaxant, cisatracurium, during total intravenous anesthesia, to stop the hiccups. The duration of the anesthetic was determined by the time it took for the patient to recover from the neuromuscular blockade without reversal the cisatracurium...
April 1, 2018: A&A practice
https://www.readbyqxmd.com/read/29121289/association-between-intraoperative-non-depolarising-neuromuscular-blocking-agent-dose-and-30-day-readmission-after-abdominal-surgery
#16
T Thevathasan, S L Shih, K C Safavi, D L Berger, S M Burns, S D Grabitz, R S Glidden, R D Zafonte, M Eikermann, J C Schneider
Background: We hypothesised that intraoperative non-depolarising neuromuscular blocking agent (NMBA) dose is associated with 30-day hospital readmission. Methods: Data from 13,122 adult patients who underwent abdominal surgery under general anaesthesia at a tertiary care hospital were analysed by multivariable regression, to examine the effects of intraoperatively administered NMBA dose on 30-day readmission (primary endpoint), hospital length of stay, and hospital costs...
October 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29119733/administration-of-fentanyl-via-a-slow-intravenous-fluid-line-compared-with-rapid-bolus-alleviates-fentanyl-induced-cough-during-general-anesthesia-induction
#17
Min-Qiang Liu, Feng-Xian Li, Ya-Kun Han, Jun-Yong He, Hao-Wen Shi, Li Liu, Ren-Liang He
OBJECTIVE: Fentanyl-induced cough (FIC) is a common complication with a reported incidence from 18.0% to 74.4% during general anesthesia induction. FIC increases the intrathoracic pressure and risks of postoperative nausea and vomiting, yet available treatments are limited. This study was designed to investigate whether administering fentanyl via a slow intravenous fluid line can effectively alleviate FIC during induction of total intravenous general anesthesia. METHODS: A total number of 1200 patients, aged 18-64 years, were enrolled, all of whom were American Society of Anesthesiologists (ASA) grade I or II undergoing scheduled surgeries...
2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/28862524/effect-of-anaesthetic-and-choice-of-neuromuscular-blocker-on-vagal-control-of-heart-rate-under-laboratory-animal-experimental-conditions
#18
Divya Sarma Kandukuri, Jacqueline K Phillips, Mark Tahmindjis, Cara M Hildreth
Neuromuscular-blocking agents are commonly used in laboratory animal research settings. Due to actions of cholinergic receptors at locations other than the motor end-plate, these agents have a strong propensity to modulate autonomic outflow and may therefore not be desirable in studies examining autonomic function. This study aimed to compare the effect of two non-depolarizing neuromuscular-blocking agents, pancuronium and cisatracurium, on blood pressure, heart rate and non-invasive indices of autonomic function (heart rate variability, systolic blood pressure variability and baroreflex sensitivity) under two different types of anaesthesia in Lewis rats...
January 1, 2017: Laboratory Animals
https://www.readbyqxmd.com/read/28770545/how-to-reduce-cisatracurium-consumption-in-ards-patients-the-tof-ards-study
#19
Sami Hraiech, Jean-Marie Forel, Christophe Guervilly, Romain Rambaud, Samuel Lehingue, Mélanie Adda, Pierre Sylla, Sabine Valera, Julien Carvelli, Marc Gainnier, Laurent Papazian, Jérémy Bourenne
BACKGROUND: Neuromuscular blocking agents (NMBAs) have been shown to improve the outcome of the most severely hypoxemic, acute respiratory distress syndrome (ARDS) patients. However, the recommended dosage as well as the necessity of monitoring the neuromuscular block is unknown. We aimed to evaluate the efficiency of a nurse-directed protocol of NMBA administration based on a train-of-four (TOF) assessment to ensure a profound neuromuscular block and decrease cisatracurium consumption compared to an elevated and constant dose regimen...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28743341/-effect-of-external-abdominal-aorta-compression-on-circulation-during-anesthesia-induction-in-elderly-patients
#20
Xiuman Li, Lixiang Wang
OBJECTIVE: To investigate the effect of external abdominal aorta compression on circulation during anesthetic induction in elderly patients. METHODS: A prospective randomized controlled trial was conducted. Patients with age of 60-75 years old, requiring a general anesthesia for non-abdominal surgery, and with II-III class of American Society of Anesthesiologists (ASA) physical status classification, and admitted to General Hospital of Chinese People's Armed Police Forces from January to April in 2017 were enrolled...
July 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
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