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https://www.readbyqxmd.com/read/29778393/fertility-preservation-in-pediatric-female-cancer-patients
#1
Sara E Arian, Rebecca L Flyckt, Richard Herman, Hadi Erfani, Tommaso Falcone
OBJECTIVE: To describe and demonstrate ovarian tissue cryopreservation (OTC) as an emerging fertility preservation technique DESIGN: Video presentation. SETTING: University hospital. PATIENT(S): A 6 year-old female patient diagnosed with aplastic anemia with plan for bone marrow transplantation underwent laparoscopic unilateral oophorectomy in conjunction with surgical procedure for port placement by the pediatric surgeon, followed by cryopreservation of ovarian tissue...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29751218/coping-strategies-of-caregivers-towards-aggressive-behaviors-of-persons-with-severe-mental-illness
#2
Neethu Bhaskaran Madathumkovilakath, Sindhu Kizhakkeppattu, Saleem Thekekunnath, Firoz Kazhungil
Aggression is one of the chief determinants of caregiver burden in severe mental illnesses. Clinical and treatment implications of aggression in mental illness are predominantly studied in perspectives of mental health care professionals. Coping style of caregivers towards aggression of persons with mental illness is understudied. So we studied coping strategies used by caregivers of patients with severe mental illness towards aggressive behaviors of patients and relationship between aggressive behavior and coping strategies...
April 24, 2018: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29732976/anaphylaxis-in-children-epidemiology-risk-factors-and-management
#3
Aikaterini Anagnostou
Anaphylaxis is defined as a serious, generalized or systemic allergic reaction that is rapid in onset and may cause death. It is unpredictable and can be the result of various allergic triggers including food, insect venom and medication. The European Anaphylaxis Registry confirmed food as the major elicitor of anaphylaxis in children, specifically hen's egg, cow's milk and nuts. It has been reported that the incidence of anaphylaxis is on the rise. In the US, there is a continued trend of increasing food-induced anaphylaxis hospitalizations among children, which is supported by nationally representative data...
May 6, 2018: Current Pediatric Reviews
https://www.readbyqxmd.com/read/29719626/identification-of-specific-and-common-diagnostic-antibody-markers-for-gastrointestinal-cancers-by-serex-screening-using-testis-cdna-phage-library
#4
Sohei Kobayashi, Takaki Hiwasa, Takahiro Arasawa, Akiko Kagaya, Sayaka Ishii, Hideaki Shimada, Masaaki Ito, Masae Suzuki, Masayuki Kano, Bahityar Rahmutulla, Kouichi Kitamura, Yuji Sawabe, Hideo Shin, Masaki Takiguchi, Fumio Nomura, Hisahiro Matsubara, Kazuyuki Matsushita
The present study was planned to identify novel serum antibody markers for digestive organ cancers. We have used screening by phage expression cloning and identified novel fourteen antigens in this experiment. The presence of auto-antibodies against these antigens in serum specimens was confirmed by western blotting. As for auto-antibodies against fourteen antigens, AlphaLISA (amplified luminescence proximity homogeneous assay) assay was performed in the sera of gastrointestinal cancers patients to confirm the results...
April 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29657893/targeting-accuracy-at-couch-kick-for-a-frameless-image-guided-radiosurgery-system
#5
Yimei Huang, Bo Zhao, Joshua Kim, Ning Wen, Indrin J Chetty, Salim Siddiqui
Purpose/Objectives: Targeting accuracy at all possible couch angles needs to be carefully evaluated prior to initiating a frameless image-guided stereotactic radiosurgery program on a Linac for treating functional disorders such as trigeminal neuralgia. In this study, we report positioning accuracy with stereoscopic x-ray imaging over the complete range of couch rotation using anthropomorphic head phantoms. Materials/Methods: An anthropomorphic head phantom with three 5 mm tungsten BBs as hidden targets was CT simulated...
2018: Journal of Radiosurgery and SBRT
https://www.readbyqxmd.com/read/29590411/wartime-soft-tissue-coverage-techniques-for-the-deployed-surgeon
#6
Vilas Saldanha, Nathan Tiedeken, Brandon Godfrey, Nichole Ingalls
Background: Since the start of the conflict in the Middle East in 2001, military orthopedic surgeons have faced complex orthopedic injuries including high-energy soft tissue wounds, traumatic amputations, and open fractures. Although orthopedic surgeons are well trained in the management of osseous injuries, the treatment of soft tissue injuries can be technically challenging and unfamiliar. Early washout, debridement of devitalized tissue, external fixation of bony injuries, and antibiotic therapy remain the foundation of early wound management...
March 26, 2018: Military Medicine
https://www.readbyqxmd.com/read/29519402/evaluation-of-a-commercial-automatic-treatment-planning-system-for-liver-stereotactic-body-radiation-therapy-treatments
#7
Elena Gallio, Francesca Romana Giglioli, Andrea Girardi, Alessia Guarneri, Umberto Ricardi, Roberto Ropolo, Riccardo Ragona, Christian Fiandra
PURPOSE: Automated treatment planning is a new frontier in radiotherapy. The Auto-Planning module of the Pinnacle3 treatment planning system (TPS) was evaluated for liver stereotactic body radiation therapy treatments. METHODS: Ten cases were included in the study. Six plans were generated for each case by four medical physics experts. The first two planned with Pinnacle TPS, both with manual module (MP) and Auto-Planning one (AP). The other two physicists generated two plans with Monaco TPS (VM)...
February 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29459741/a-fuzzy-feature-fusion-method-for-auto-segmentation-of-gliomas-with-multi-modality-diffusion-and-perfusion-magnetic-resonance-images-in-radiotherapy
#8
Lu Guo, Ping Wang, Ranran Sun, Chengwen Yang, Ning Zhang, Yu Guo, Yuanming Feng
The diffusion and perfusion magnetic resonance (MR) images can provide functional information about tumour and enable more sensitive detection of the tumour extent. We aimed to develop a fuzzy feature fusion method for auto-segmentation of gliomas in radiotherapy planning using multi-parametric functional MR images including apparent diffusion coefficient (ADC), fractional anisotropy (FA) and relative cerebral blood volume (rCBV). For each functional modality, one histogram-based fuzzy model was created to transform image volume into a fuzzy feature space...
February 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29449099/cost-of-goods-sold-and-total-cost-of-delivery-for-oral-and-parenteral-vaccine-packaging-formats
#9
Jeff Sedita, Stefanie Perrella, Matt Morio, Michael Berbari, Jui-Shan Hsu, Eugene Saxon, Courtney Jarrahian, Annie Rein-Weston, Darin Zehrung
Despite limitations of glass packaging for vaccines, the industry has been slow to implement alternative formats. Polymer containers may address many of these limitations, such as breakage and delamination. However, the ability of polymer containers to achieve cost of goods sold (COGS) and total cost of delivery (TCOD) competitive with that of glass containers is unclear, especially for cost-sensitive low- and lower-middle-income countries. COGS and TCOD models for oral and parenteral vaccine packaging formats were developed based on information from subject matter experts, published literature, and Kenya's comprehensive multiyear plan for immunization...
March 14, 2018: Vaccine
https://www.readbyqxmd.com/read/29415461/does-walkability-contribute-to-geographic-variation-in-psychosocial-distress-a-spatial-analysis-of-91-142-members-of-the-45-and-up-study-in-sydney-australia
#10
Darren J Mayne, Geoffrey G Morgan, Bin B Jalaludin, Adrian E Bauman
Walkability describes the capacity of the built environment to promote walking, and has been proposed as a potential focus for community-level mental health planning. We evaluated this possibility by examining the contribution of area-level walkability to variation in psychosocial distress in a population cohort at spatial scales comparable to those used for regional planning in Sydney, Australia. Data on psychosocial distress were analysed for 91,142 respondents to the 45 and Up Study baseline survey between January 2006 and April 2009...
February 6, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29397212/real-time-whole-brain-radiation-therapy-a-single-institution-experience
#11
Anh H Le, Strahinja Stojadinovic, Robert Timmerman, Hak Choy, Romona L Duncan, Steve B Jiang, Arnold Pompos
PURPOSE: To demonstrate the feasibility of a real-time whole-brain radiation therapy (WBRT) workflow, taking advantage of contemporary radiation therapy capabilities and seeking to optimize clinical workflow for WBRT. METHODS AND MATERIALS: We developed a method incorporating the linear accelerator's on-board imaging system for patient simulation, used cone-beam computed tomography (CBCT) data for treatment planning, and delivered the first fraction of prescribed therapy, all during the patient's initial appointment...
December 28, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29394292/correction-gbm-auto-a-software-tool-to-simplify-spatial-modelling-and-marine-protected-area-planning
#12
Simon Dedman, Rick Officer, Maurice Clarke, David G Reid, Deirdre Brophy
[This corrects the article DOI: 10.1371/journal.pone.0188955.].
2018: PloS One
https://www.readbyqxmd.com/read/29362433/application-of-cardiovascular-virtual-endoscopy-a-pilot-study-on-roaming-path-planning-for-diagnosis-of-congenital-heart-diseases-in-children
#13
Li-Ping Yao, Ju Mei, Fang-Bao Ding, Li Zhang, Hui-Ming Li, Ming Ding, Xin Yang, Xiao-Ming Li, Kun Sun
To investigate roaming paths planning for diagnosis of congenital heart diseases (CHD) using a cardiovascular virtual endoscopy (VE) system. Forty children were enrolled. VE system was applied to support in establishing a diagnosis. Performance in diagnosing CHDs by CT, VE using automatically planned roaming paths (VE-auto, objects were treated as left heart system and right heart system), VE using manually planned paths (VE-manual), and VE using automatically planned path for left heart system and manually planned path for right heart system (VE-combined) were studied and compared...
January 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29357875/optimization-of-dose-distributions-of-target-volumes-and-organs-at-risk-during-stereotactic-body-radiation-therapy-for-pancreatic-cancer-with-dose-limiting-auto-shells
#14
Yangsen Cao, Xiaofei Zhu, Xiaoping Ju, Yongming Liu, Chunshan Yu, Yongjian Sun, Zhitao Dai, Xueling Guo, Huojun Zhang
BACKGROUND: To identify optimization of dose distributions of target volumes and decrease of radiation doses to normal tissues during stereotactic body radiation therapy (SBRT) for pancreatic cancer with dose-limiting auto-shells. METHODS: With the same prescription dose, dose constraints of normal organs and calculation algorithm, treatment plans of each eligible patient were re-generated with 3 shells, 5 shells and 7 shells, respectively. The prescription isodose line and beam number of each patient in 3-shell, 5-shell and 7-shell plan remained the same...
January 22, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29351303/automated-inverse-optimization-facilitates-lower-doses-to-normal-tissue-in-pancreatic-stereotactic-body-radiotherapy
#15
Ivaylo B Mihaylov, Eric A Mellon, Raphael Yechieli, Lorraine Portelance
PURPOSE: Inverse planning is trial-and-error iterative process. This work introduces a fully automated inverse optimization approach, where the treatment plan is closely tailored to the unique patient anatomy. The auto-optimization is applied to pancreatic stereotactic body radiotherapy (SBRT). MATERIALS AND METHODS: The automation is based on stepwise reduction of dose-volume histograms (DVHs). Five uniformly spaced points, from 1% to 70% of the organ at risk (OAR) volumes, are used...
2018: PloS One
https://www.readbyqxmd.com/read/29338154/characteristics-etiology-and-treatment-of-pediatric-and-adult-anaphylaxis-in-iran
#16
Mohammad Nabavi, Mehrnoosh Lavavpour, Saba Arshi, Mohammad Hasan Bemanian, Hossein Esmaeilzadeh, Rasool Molatefi, Mahsa Rekabi, Javad Ahmadian, Narges Eslami, Sima Shokri, Kian Darabi, Gholam Reza Sedighi, Morteza Fallahpour
Despite the increasing prevalence of anaphylaxis, there is little information about the characteristics and practice of healthcare providers in treating anaphylaxis, so this study was conducted to record the characteristics and therapeutic approaches of anaphylaxis from May 2012 until April 2015, the data of all patients diagnosed with anaphylaxis in the Allergy department of three referral university hospitals in Tehran, Iran were recorded. Thereafter, the demographics, clinical features, triggers and therapeutic approach were evaluated...
December 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29333408/is-long-term-storage-of-cryopreserved-stem-cells-for-hematopoietic-stem-cell-transplantation-a-worthwhile-exercise-in-developing-countries
#17
Santhosh Kumar Devadas, Minal Khairnar, Sumathi S Hiregoudar, Shashank Ojha, Sachin Punatar, Alok Gupta, Anant Gokarn, Pallavi Bhole, Sadhana Kannan, Navin Khattry
Background: Stem cell units (SCUs) that are cryopreserved prior to both autologous and allogeneic hematopoietic stem cell transplants (for donor lymphocyte infusion) remain unused or partially used several times, and become an increased burden to blood banks/SCU repositories. Because of the scarcity of data regarding the duration for which the storage is useful, there is no general consensus regarding disposal of SCUs. Methods: We conducted a retrospective audit of SCU utilization in 435 patients who planned to undergo either autologous stem cell transplantation (auto-SCT) (N=239) or allogeneic stem cell transplantation (allo-SCT) (N=196) at a tertiary cancer care center between November 2007 to January 2015...
December 2017: Blood Research
https://www.readbyqxmd.com/read/29328050/threshold-driven-optimization-for-reference-based-auto-planning
#18
Troy Long, Mingli Chen, Steve Jiang, Weiguo Lu
We study threshold-driven optimization methodology for automatically generating a treatment plan that is motivated by a reference DVH for IMRT treatment planning. We present a framework for threshold-driven optimization for reference-based auto-planning (TORA). Commonly used voxel-based quadratic penalties have two components for penalizing under- and over-dosing of voxels: a reference dose threshold and associated penalty weight. Conventional manual- and auto-planning using such a function involves iteratively updating the preference weights while keeping the thresholds constant, an unintuitive and often inconsistent method for planning toward some reference DVH...
February 8, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29248057/medicaid-program-choice-inertia-and-adverse-selection
#19
James Marton, Aaron Yelowitz, Jeffery C Talbert
In 2012, Kentucky implemented Medicaid managed care statewide, auto-assigned enrollees to three plans, and allowed switching. Using administrative data, we find that the state's auto-assignment algorithm most heavily weighted cost-minimization and plan balancing, and placed little weight on the quality of the enrollee-plan match. Immobility - apparently driven by health plan inertia - contributed to the success of the cost-minimization strategy, as more than half of enrollees auto-assigned to even the lowest quality plans did not opt-out...
December 2017: Journal of Health Economics
https://www.readbyqxmd.com/read/29216310/gbm-auto-a-software-tool-to-simplify-spatial-modelling-and-marine-protected-area-planning
#20
Simon Dedman, Rick Officer, Maurice Clarke, David G Reid, Deirdre Brophy
BOOSTED REGRESSION TREES. EXCELLENT FOR DATA-POOR SPATIAL MANAGEMENT BUT HARD TO USE: Marine resource managers and scientists often advocate spatial approaches to manage data-poor species. Existing spatial prediction and management techniques are either insufficiently robust, struggle with sparse input data, or make suboptimal use of multiple explanatory variables. Boosted Regression Trees feature excellent performance and are well suited to modelling the distribution of data-limited species, but are extremely complicated and time-consuming to learn and use, hindering access for a wide potential user base and therefore limiting uptake and usage...
2017: PloS One
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