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https://www.readbyqxmd.com/read/28881055/individual-healthcare-plan-for-allergic-children%C3%A2-at-school-lessons-from-a-2015-2016-school-year-survey
#1
Guillaume Pouessel, Stépanie Lejeune, Marie-Pierre Dupond, Annie Renard, Camille Fallot, Antoine Deschildre
The Individual Healthcare Plan (IHP) was implemented in schools in France in 2003 to improve management of allergic children. Our objectives were to assess the practical aspects of IHP (excluding asthma) and allergic reactions occurring at school. METHODS: Prospective study conducted in the North Department (France) during the 2015/2016 school-year. Two questionnaires were developed: one for the school doctors (n=67) and one for the school principals (n=2372). RESULTS: Data from 336 (25%) of the 1325 IHPs (0...
September 7, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28865314/safety-analysis-of-urban-arterials-at-the-meso-level
#2
Jia Li, Xuesong Wang
Urban arterials form the main structure of street networks. They typically have multiple lanes, high traffic volume, and high crash frequency. Classical crash prediction models investigate the relationship between arterial characteristics and traffic safety by treating road segments and intersections as isolated units. This micro-level analysis does not work when examining urban arterial crashes because signal spacing is typically short for urban arterials, and there are interactions between intersections and road segments that classical models do not accommodate...
August 30, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28854714/routine-serum-thyroid-stimulating-hormone-testing-optimizing-pre-conception-health-or-generating-toxic-knowledge
#3
Abha Maheshwari, Priya Bhide, Jyotsna Pundir, Siladitya Bhattacharya
Monitoring subclinical hypothyroidism (SCH) in women is believed to be important in terms of preventing overt hypothyroidism and optimizing the health and cognitive development of their children. Current systematic reviews have suggested an association between maternal SCH and adverse obstetric and neonatal outcomes. However, initiating the administration of thyroxine during pregnancy has failed to demonstrate appreciable health benefits. Hence there are calls by professional endocrine societies for optimizing serum thyroid-stimulating hormone (TSH) levels pre-conception...
September 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28840767/automatic-treatment-planning-facilitates-fast-generation-of-high-quality-treatment-plans-for-esophageal-cancer
#4
Christian Rønn Hansen, Morten Nielsen, Anders Smedegaard Bertelsen, Irene Hazell, Eva Holtved, Ruta Zukauskaite, Jon Kroll Bjerregaard, Carsten Brink, Uffe Bernchou
BACKGROUND: The quality of radiotherapy planning has improved substantially in the last decade with the introduction of intensity modulated radiotherapy. The purpose of this study was to analyze the plan quality and efficacy of automatically (AU) generated VMAT plans for inoperable esophageal cancer patients. MATERIAL AND METHODS: Thirty-two consecutive inoperable patients with esophageal cancer originally treated with manually (MA) generated volumetric modulated arc therapy (VMAT) plans were retrospectively replanned using an auto-planning engine...
August 25, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28793876/patient-satisfaction-with-extavipro%C3%A2-30g-a-new-auto-injector-for-administering-interferon-%C3%AE-1b-in-multiple-sclerosis-results-from-a-real-world-observational-exchange-study
#5
Frank A Hoffmann, Anastasiya Trenova, Miguel A Llaneza, Johannes Fischer, Giacomo Lus, Dorothea von Bredow, Núria Lara, Elaine Lam, Marlies Van Hoef, Rajesh Bakshi
BACKGROUND: Patients with multiple sclerosis (MS) receiving long-term, subcutaneous interferon β-1b (IFN β-1b; Extavia®) often experience injection-site reactions and injection-site pain, which together with other side-effects (such as flu-like symptoms) result in suboptimal treatment compliance/adherence. The EXCHANGE study evaluated patient satisfaction with IFN β-1b treatment, administered using ExtaviPro™ 30G, a new auto-injector, in a real-world setting. METHODS: This 26-week, open-label, prospective, non-interventional, observational, multi-country multi-centre study enrolled patients with MS who had been treated with IFN β-1b or other disease-modifying therapies with a self-administered auto-injector for ≥3 months and who were planned to switch to IFN β-1b treatment administered using ExtaviPro™ 30G as part of routine clinical care...
August 9, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28770294/automated-imrt-planning-in-pinnacle-a%C3%A2-study-in-head-and-neck-cancer
#6
J M A M Kusters, K Bzdusek, P Kumar, P G M van Kollenburg, M C Kunze-Busch, M Wendling, T Dijkema, J H A M Kaanders
PURPOSE: This study evaluates the performance and planning efficacy of the Auto-Planning (AP) module in the clinical version of Pinnacle 9.10 (Philips Radiation Oncology Systems, Fitchburg, WI, USA). METHODS AND MATERIALS: Twenty automated intensity-modulated radiotherapy (IMRT) plans were compared with the original manually planned clinical IMRT plans from patients with oropharyngeal cancer. RESULTS: Auto-Planning with IMRT offers similar coverage of the planning target volume as the original manually planned clinical plans, as well as better sparing of the contralateral parotid gland, contralateral submandibular gland, larynx, mandible, and brainstem...
August 2, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28768920/neuronavigation-guided-frameless-stereoelectroencephalography-seeg
#7
Ayataka Fujimoto, Tohru Okanishi, Sotaro Kanai, Keishiro Sato, Mitsuyo Nishimura, Hideo Enoki
Stereoelectroencephalography (SEEG) is an invasive surgical procedure used to identify epileptogenic zones. The combination of both subdural grids and depth electrodes (DEs) is currently used for invasive intracranial monitoring in many epilepsy centers. To perform DE implantation, some centers use frame-based stereotactic techniques and others use stereotactic robotic techniques. However, not all epilepsy centers have access to these tools. We hypothesized that DE implantation using a neuronavigation system can be utilized for subsequent epilepsy surgery...
August 1, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/28754289/dosimetric-benefits-of-automation-in-the-treatment-of-lower-thoracic-esophageal-cancer-is-manual-planning-still-an-alternative-option
#8
Xiadong Li, Lu Wang, Jiahao Wang, Xu Han, Bing Xia, Shixiu Wu, Weigang Hu
This study aimed to design automated volumetric-modulated arc therapy (VMAT) plans in Pinnacle auto-planning and compare it with manual plans for patients with lower thoracic esophageal cancer (EC). Thirty patients with lower thoracic EC were randomly selected for replanning VMAT plans using auto-planning in Pinnacle treatment planning system (TPS) version 9.10. Historical plans of these patients were then compared. Dose-volume histogram (DVH) statistics, dose uniformity, and dose homogeneity were analyzed to evaluate treatment plans...
July 25, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28731267/heuristic-knowledge-based-planning-for-single-isocenter-stereotactic-radiosurgery-to-multiple-brain-metastases
#9
Benjamin P Ziemer, Parag Sanghvi, Jona Hattangadi-Gluth, Kevin L Moore
PURPOSE: Single-isocenter, volumetric modulated arc therapy (VMAT) stereotactic radiosurgery (SRS) for multiple brain metastases (multi-mets) can deliver highly conformal dose distributions and reduce overall patient treatment time compared to other techniques. However, treatment planning for multi-met cases is highly complex due to variability in numbers and sizes of brain metastases, as well as their relative proximity to organs-at-risk (OARs). The purpose of this study was to automate the VMAT planning of multi-met cases through a knowledge-based planning (KBP) approach that adapts single target SRS dose predictions to multiple target predictions...
July 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/28692818/establishing-an-autologous-versus-allogeneic-hematopoietic-cell-transplant-program-in-nations-with-emerging-economies
#10
REVIEW
Naeem A Chaudhri, Mahmoud Aljurf, Fahad I Almohareb, Hazzaa A Alzahrani, Qaiser Bashir, Bipin Savani, Vikas Gupta, Shahrukh K Hashmi
More than 70,000 hematopoietic cell transplants are currently performed each year, and these continue to increase every year. However, there is a significant variation in the number of absolute transplants and transplant rates between centers, countries, and global regions. The prospect for emerging countries to develop a hematopoietic cell transplantation (HCT) program, as well as to decide on whether autologous HCT (auto-HCT) or allogeneic HCT (allo-HCT) should be established to start with, relies heavily on factors that can explain differences between these two procedures...
July 3, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28653120/automation-of-radiation-treatment-planning-evaluation-of-head-and-neck-cancer-patient-plans-created-by-the-pinnacle-3-scripting-and-auto-planning-functions
#11
COMPARATIVE STUDY
Stefan Speer, Andreas Klein, Lukas Kober, Alexander Weiss, Indra Yohannes, Christoph Bert
BACKGROUND: Intensity-modulated radiotherapy (IMRT) techniques are now standard practice. IMRT or volumetric-modulated arc therapy (VMAT) allow treatment of the tumor while simultaneously sparing organs at risk. Nevertheless, treatment plan quality still depends on the physicist's individual skills, experiences, and personal preferences. It would therefore be advantageous to automate the planning process. This possibility is offered by the Pinnacle(3) treatment planning system (Philips Healthcare, Hamburg, Germany) via its scripting language or Auto-Planning (AP) module...
August 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28639013/revisiting-the-environmental-kuznets-curve-and-pollution-haven-hypotheses-mikta-sample
#12
Ibrahim Bakirtas, Mumin Atalay Cetin
This study aims to examine the validity of the environmental Kuznets curve (EKC) and pollution haven hypotheses in Mexico, Indonesia, South Korea, Turkey, and Australia (MIKTA) countries from 1982 to 2011 by using a panel vector auto regressive (PVAR) model. Empirical findings imply that the EKC hypothesis is rejected by the MIKTA sample. However, PVAR estimations reveal Granger causality from income level, foreign direct investment (FDI) inward, and energy consumption to CO2 emissions. Orthogonalized impulse-response functions are derived from PVAR estimations...
June 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28617238/public-health-policy-in-support-of-insurance-coverage-for-smoking-cessation-treatments
#13
Robert Schwartz, Farzana Haji, Alexey Babayan, Christopher Longo, Roberta Ferrence
Insurance coverage for evidence-based smoking cessation treatments (SCTs) promotes uptake and reduces smoking rates. Published studies in this area are based in the US where employers are the primary source of health insurance. In Ontario, Canada, publicly funded healthcare does not cover SCTs, but it can be supplemented with employer-sponsored benefit plans. This study explores factors affecting the inclusion/exclusion of smoking cessation (SC) benefits. In total, 17 interviews were conducted with eight employers (auto, retail, banking, municipal and university industries), four health insurers, two government representatives and three advisors/consultants...
May 2017: Healthcare Policy, Politiques de Santé
https://www.readbyqxmd.com/read/28598564/withdrawn-celecoxib-for-rheumatoid-arthritis
#14
REVIEW
Sarah E Garner, Dogan Fidan, Ruth R Frankish, Maria Judd, Beverley Shea, Tanveer Towheed, Peter Tugwell, George A Wells
BACKGROUND: Rheumatoid arthritis (RA) is a systemic auto-immune disorder, involving persistent joint inflammation. NSAIDs are used to control the symptoms of RA, but are associated with significant gastro-intestinal toxicity, including a risk of potentially life threatening gastroduodenal perforations, ulcers and bleeds. The NSAIDs known as the selective Cox II inhibitors, of which celecoxib is a member, were developed in order to reduce the GI toxicity, but are more expensive. OBJECTIVES: To establish the efficacy and safety of celecoxib in the management of RA by systematic review of available evidence...
June 9, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28573978/automatic-contour-propagation-using-deformable-image-registration-to-determine-delivered-dose-to-spinal-cord-in-head-and-neck-cancer-radiotherapy
#15
Ping Lin Yeap, David Noble, Karl Harrison, Amy Bates, Neil Burnet, Rajesh Jena, Marina Romanchikova, Michael Sutcliffe, Simon Thomas, Gill Barnett, Richard Benson, Sarah Jefferies, M Parker
To determine delivered dose to the spinal cord, a technique has been developed to propagate manual contours from kilovoltage computed-tomography (kVCT) scans for treatment planning to megavoltage computed-tomography (MVCT) guidance scans. The technique uses the Elastix software to perform intensity-based deformable image registration of each kVCT scan to the associated MVCT scans. The registration transform is then applied to contours of the spinal cord drawn manually on the kVCT scan, to obtain contour positions on the MVCT scans...
June 2, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28562113/anaphylaxis-epidemiology-aetiology-and-relevance-for-the-clinic
#16
Sangeeta Dhami, Aziz Sheikh
Anaphylaxis is responsible for considerable morbidity and may in some cases prove fatal. Areas covered: This review summarises the findings from recent studies on the epidemiology and aetiology of anaphylaxis and draws on the insights from this work and recent international guidelines to consider the implications for clinical care. Acute management of anaphylaxis is centred on early recognition, treatment with adrenaline (epinephrine) and other essential life-support measures. The importance of longer-term care of patients with a history of or at risk of anaphylaxis are also considered with a view to minimising the risk of further reactions...
September 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/28549556/evaluation-of-a-commercial-automatic-treatment-planning-system-for-prostate-cancers
#17
Kanabu Nawa, Akihiro Haga, Akihiro Nomoto, Raniel A Sarmiento, Kenshiro Shiraishi, Hideomi Yamashita, Keiichi Nakagawa
Recent developments in Radiation Oncology treatment planning have led to the development of software packages that facilitate automated intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) planning. Such solutions include site-specific modules, plan library methods, and algorithm-based methods. In this study, the plan quality for prostate cancer generated by the Auto-Planning module of the Pinnacle(3) radiation therapy treatment planning system (v9.10, Fitchburg, WI) is retrospectively evaluated...
May 23, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28533050/dual-core-steered-non-rigid-registration-for-multi-modal-images-via-bi-directional-image-synthesis
#18
Xiaohuan Cao, Jianhua Yang, Yaozong Gao, Yanrong Guo, Guorong Wu, Dinggang Shen
In prostate cancer radiotherapy, computed tomography (CT) is widely used for dose planning purposes. However, because CT has low soft tissue contrast, it makes manual contouring difficult for major pelvic organs. In contrast, magnetic resonance imaging (MRI) provides high soft tissue contrast, which makes it ideal for accurate manual contouring. Therefore, the contouring accuracy on CT can be significantly improved if the contours in MRI can be mapped to CT domain by registering MRI with CT of the same subject, which would eventually lead to high treatment efficacy...
May 13, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28508307/duration-of-antiviral-prophylaxis-and-risk-of-herpes-zoster-among-patients-receiving-autologous-hematopoietic-stem-cell-transplants-a-retrospective-observational-study
#19
Dongmu Zhang, Thomas Weiss, Yu Feng, Lynn Finelli
INTRODUCTION: There are no real-world data on antiviral prophylaxis (AP) duration and risk of herpes zoster (HZ) given AP duration in patients receiving autologous hematopoietic stem cell transplants (auto-HSCT). The objectives of this study are to describe the duration of AP and to compare incidence of HZ by AP duration in auto-HSCT patients. METHODS: This is a retrospective, observational database (Marketscan(®)) study. This study included patients ≥18 years old who had auto-HSCT during 2009-2013, had chemotherapy within 60 days prior to auto-HSCT (latest chemotherapy date within the 60 days was the study enrollment date), and had continuous health plan enrollment for at least 365 days before and after the study enrollment date...
July 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28492509/transcriptomic-profiling-of-the-allorecognition-response-to-grafting-in-the-demosponge-amphimedon-queenslandica
#20
Laura F Grice, Bernard M Degnan
Sponges, despite their simple body plan, discriminate between self and nonself with remarkable specificity. Sponge grafting experiments simulate the effects of natural self or nonself contact under laboratory conditions. Here we take a transcriptomic approach to investigate the temporal response to self and nonself grafts in the marine demosponge Amphimedon queenslandica. Auto- and allografts were established, observed and sampled over a period of three days, over which time the grafts either rejected or accepted, depending on the identity of the paired individuals, in a replicable and predictable manner...
May 11, 2017: Marine Drugs
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