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Thinking outside the box

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https://www.readbyqxmd.com/read/28818156/time-for-surgeons-to-think-outside-the-anatomical-box
#1
Raj C Dedhia
No abstract text is available yet for this article.
August 14, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28795989/thinking-outside-the-box
#2
(no author information available yet)
No abstract text is available yet for this article.
August 8, 2017: Nursing
https://www.readbyqxmd.com/read/28761015/the-evolution-of-culture-or-the-lack-thereof-mapping-the-conceptual-space
#3
Raghavendra Gadagkar
This short essay is based on a lecture that I gave at short notice on a subject in which I am by no means an expert. The combination of lack of expertise and time for preparation, created an unexpectedly unique opportunity for thinking outside the box. I decided not to try to read up (as there was no time in any case) but instead to organize the little that I already knew about cultural evolution in a systematic schema-I attempted to create a scaffolding, on which I could hang everything I knew about cultural evolution, and hopefully, everything I might ever discover about cultural evolution in the future...
July 2017: Journal of Genetics
https://www.readbyqxmd.com/read/28741488/extraordinary-cancer-epigenomics-thinking-outside-the-classical-coding-and-promoter-box
#4
REVIEW
Matthew Murtha, Manel Esteller
The advent of functional genomics powered by high-throughput sequencing has given us a new appreciation of the genomic sequences that lie outside the canonical promoter-coding sequence box. These regions harbor distant regulatory elements, enhancers, super-enhancers, insulators, alternative promoters, and sequences that transcribe as noncoding RNAs (ncRNAs) such as miRNAs and long ncRNAs. These functional genomics studies have also enabled a clearer understanding of the role of the 3D structure of the genome in epigenetic regulation...
October 2016: Trends in Cancer
https://www.readbyqxmd.com/read/28661748/modernizing-research-regulations-is-not-enough-it-s-time-to-think-outside-the-regulatory-box
#5
Suzanne M Rivera, Kyle B Brothers, R Jean Cadigan, Heather L Harrell, Mark A Rothstein, Richard R Sharp, Aaron J Goldenberg
No abstract text is available yet for this article.
July 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/28646406/podocytes-and-the-quest-for-precision-medicines-for-kidney-diseases
#6
REVIEW
Peter Mundel
In this review, I describe a 30-year journey in the quest for precision medicines for patients with kidney diseases. In 1987, when I started my reseach career, most scientists studying glomerular disease biology were focused on mesangial cells. The crucial role of the podocyte in many kidney diseases characterized by proteinuria, including focal segmental glomerulosclerosis (FSGS) and diabetic nephropathy, had not yet been recognized. We were not aware of genetic causes or drivers of kidney diseases nor of molecular markers and cell culture systems for mechanistic studies of podocyte biology...
August 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28640959/the-deeper-self-an-expanded-view-of-consciousness
#7
Steve Paulson, Siri Hustvedt, Mark Solms, Sonu Shamdasani
As science continues to explore the mysteries of the unconscious, two critical questions remain. First, can unconscious impulses, desires, and feelings be willfully raised to the level of the conscious self?, and, if so, would the unveiling of unconscious mechanisms lead to genuine self-knowledge or empowerment? Second, can we methodically tap into the unconscious to gear ourselves along more creative lines? If the unconscious is a source of intuitive and creative inspiration, how might a more expansive understanding of consciousness help us to flourish? How can we harness the intuitive parts of ourselves to think "outside the box," transcending the limitations of preconceived categories? And along those same lines, how would an expanded view of the unconscious frame our spiritual experiences or offer spiritual nourishment? Writer Siri Hustvedt, historian of psychology Sonu Shamdasani, and neuropsychologist Mark Solms will tackle everything from noetic experiences and the role of intuition to the phenomenon of peak experience and Jung's "collective unconscious...
June 22, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28551051/time-to-think-outside-the-box-prompt-individualised-safe-management-pr-i-s-m-should-prevail-in-patients-with-multiple-injuries
#8
EDITORIAL
P V Giannoudis, Vasileios P Giannoudis, Daniel S Horwitz
No abstract text is available yet for this article.
May 19, 2017: Injury
https://www.readbyqxmd.com/read/28550145/paediatric-innovation-in-pakistan-our-experience-and-a-call-to-action
#9
Walid Farooqi, Faysal Subhani, Asad Mian
Standardisation in paediatric medicine may have the unintended effect of stifling innovation. Thinking outside the box becomes even more important in low-income to middle-income countries like Pakistan, where a large paediatric population requires healthcare. In addition, there is always a lack of funds, making an innovative, low-cost and high impact solution all the more necessary. While regulation and formal research is an integral part of the process, the local synthesis of a solution must start with a creative idea...
May 26, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28432171/ascites-in-a-patient-with-episodic-angio-oedema-and-eosinophilia-thinking-outside-the-box
#10
Eirini I Rigopoulou, Maria Ioannou, Georgia Papadamou, Georgios N Dalekos
Episodic angio-oedema with eosinophilia (EAE) or Gleich's syndrome is a rare condition characterised by recurrent episodes of oedema and eosinophilia, accompanied by urticaria, fever and weight gain. The presence of ascites has not been reported so far. We report a 21-year-old Caucasian woman who presented with marked ocular oedema and ascites. Laboratory evaluation revealed marked eosinophilia. During the last 3 months, three episodes of facial and neck oedema were reported, which resolved spontaneously over a period of 3-5 days...
April 21, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28427333/the-experiences-of-physiotherapists-treating-people-with-dementia-who-fracture-their-hip
#11
A J Hall, R Watkins, I A Lang, R Endacott, V A Goodwin
BACKGROUND: It is estimated that people with dementia are approximately three times more likely to fracture their hip than sex and age matched controls. A report by the Chartered Society of Physiotherapy found that this population have poor access to rehabilitation as inpatients and in the community. A recent scoping review found a paucity of research in this area, indeed there has been no qualitative research undertaken with physiotherapists. In order to address this evidence gap, the aim of this current study was to explore the experiences of physiotherapists treating this population...
April 20, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28422918/reassessing-the-cardiac-box-a-comprehensive-evaluation-of-the-relationship-between-thoracic-gunshot-wounds-and-cardiac-injury
#12
Rashi Jhunjhunwala, Michael J Mina, Elizabeth I Roger, Christopher J Dente, Michael Heninger, Jacquelyn S Carr, Stacy D Dougherty, Rondi B Gelbard, Jeffrey M Nicholas, Amy D Wyrzykowski, David V Feliciano, Bryan C Morse
BACKGROUND: High energy missiles can cause cardiac injury regardless of entrance site. This study assesses the adequacy of the anatomic borders of the current "cardiac box" to predict cardiac injury. METHODS: Retrospective autopsy review was performed to identify patients with penetrating torso gunshot wounds 2011-2013. Using a circumferential grid system around the thorax, logistic regression analysis was performed to detect differences in rates of cardiac injury from entrance/exit wounds in the "cardiac box" vs...
April 18, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28393387/dental-students-reflections-about-long-term-care-experiences-through-an-existing-model-of-oral-health
#13
Mario Brondani, Komkham Pattanaporn
OBJECTIVE: The aim of this study was to explore students' reflective thinking about long-term care experiences from the perspective of a model of oral health. MATERIALS AND METHODS: A total of 186 reflections from 193 second-year undergraduate dental students enrolled between 2011/12 and 2014/15 at the University of British Columbia were explored qualitatively. Reflections had a word limit of 300, and students were asked to relate an existing model of oral health to their long-term care experiences...
April 10, 2017: Gerodontology
https://www.readbyqxmd.com/read/28380677/thinking-outside-the-box
#14
EDITORIAL
Claire Su-Yeon Park
Much evidence supports that having more nurses leads to better patient outcomes. However, why is nurse staffing still lacking in practice? Previous studies on the nursing workforce have, so far, focused on determining 'more nurses and better patient outcomes.' However, a controversial debate on the cost-effectiveness of hiring more nurses still continues (Aiken et al. 2011). When it comes to nursing workforce policy-materializing in practice, the inconclusiveness of nursing efficiency is considered to be one of the critical reasons for the failure to narrow the gap between the ideal and the real...
April 5, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28376665/thinking-outside-the-box
#15
Judith Ingles, Chandrashekara N Kyathanahalli, Pancharatnam Jeyasuria, Jennifer C Condon
A broad definition of preconditioning is "the preparation for a subsequent action." Mounting evidence demonstrates that novel remote preconditioning paradigms, in which protective stimuli experienced locally can capacitate systemic tolerance and enhanced cell viability upon exposure to ensuing cellular insults, have been largely successful in the field of cardiovascular ischemia/reperfusion injury. To ensure successful protective preconditioning, some models (including the uterus) have been demonstrated to activate the unfolded protein response (UPR), which is a cellular stress response controlled at the level of the endoplasmic reticulum...
July 2017: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28231260/effects-of-the-skills4genius-sports-based-training-program-in-creative-behavior
#16
Sara Santos, Sergio Jiménez, Jaime Sampaio, Nuno Leite
Team Sports has been suggested as a suitable environment to investigate creative behavior. This study's purpose was two-fold: first, it intended to identify the effects of the Skills4Genius sports-bases training program in thinking, motor, and in-game creative behavior in team sports. Second, it aimed to investigate the relationship between creative thinking and in-game creativity. Forty children from primary school were allocated into control (n = 18, age: 9.2±0.4) and experimental (n = 22, age: 9.5±0.7) groups...
2017: PloS One
https://www.readbyqxmd.com/read/28029472/the-role-of-interventional-cardiology-to-our-understanding-of-basic-mechanisms-related-to-coronary-atherosclerosis-thinking-outside-the-box
#17
REVIEW
Konstantinos Dean Boudoulas, Christodoulos Stefanadis, Harisios Boudoulas
Interventional cardiology has contributed significantly to our understanding of coronary atherosclerosis. Interventional cardiology has allowed a correlation between the clinical picture of coronary atherosclerosis with the underlying pathology and has helped establish the evolution of atherosclerotic plaques in vivo. Better understanding of the basic mechanisms of coronary atherosclerosis, due to the contributions of interventional cardiology, will help cure and/or prevent coronary atherosclerosis in the next few decades...
March 2017: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/28007231/-think-outside-the-box-visionary-of-cross-training
#18
EDITORIAL
Tsuyoshi Kaneko
No abstract text is available yet for this article.
January 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27790469/student-project-in-anatomy-spa-making-the-first-year-medical-students-responsible-and-creative
#19
Satheesha B Nayak, Snigdha Mishra, Bincy M George, Naveen Kumar
INTRODUCTION: Creativity is a combination of ones' capacity to think outside the box, the gained knowledge and the passion for creating something. It very easily and effectively provides the creator a chance to be responsible for his/her creation and acts as a confidence booster for him/her. Creativity is inherent, but needs to be polished and nurtured. If nurtured well through proper motivation, the creator excels leaps and bounds. It develops an empathetic behaviour in the creator, when he allows his creations to be used by others...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27709892/current-challenges-toward-in-vitro-cellular-validation-of-inorganic-nanoparticles
#20
REVIEW
Malou Henriksen-Lacey, Susana Carregal-Romero, Luis M Liz-Marzán
An impressive development has been achieved toward the production of well-defined "smart" inorganic nanoparticles, in which the physicochemical properties can be controlled and predicted to a high degree of accuracy. Nanoparticle design is indeed highly advanced, multimodal and multitargeting being the norm, yet we do not fully understand the obstacles that nanoparticles face when used in vivo. Increased cooperation between chemists and biochemists, immunologists and physicists, has allowed us to think outside the box, and we are slowly starting to understand the interactions that nanoparticles undergo under more realistic situations...
January 18, 2017: Bioconjugate Chemistry
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