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Thinking outside the box

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https://www.readbyqxmd.com/read/27790469/student-project-in-anatomy-spa-making-the-first-year-medical-students-responsible-and-creative
#1
Satheesha B Nayak, Snigdha Mishra, Bincy M George, Naveen Kumar
INTRODUCTION: Creativity is a combination of ones' capacity to think outside the box, the gained knowledge and the passion for creating something. It very easily and effectively provides the creator a chance to be responsible for his/her creation and acts as a confidence booster for him/her. Creativity is inherent, but needs to be polished and nurtured. If nurtured well through proper motivation, the creator excels leaps and bounds. It develops an empathetic behaviour in the creator, when he allows his creations to be used by others...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27709892/current-challenges-towards-in-vitro-cellular-validation-of-inorganic-nanoparticles
#2
Malou Henriksen-Lacey, Susana Carregal-Romero, Luis M Liz-Marzán
An impressive development has been achieved toward the production of well defined "smart" inorganic nanoparticles, in which the physicochemical properties can be controlled and predicted to a high degree of accuracy. Nanoparticle design is indeed highly advanced, multi-modal and multi-targeting being the norm, yet we do not fully understand yet the obstacles that nanoparticles face when used in vivo. Increased cooperation between chemists and biochemists, immunologists and physicists, has allowed us to think outside the box and we are slowly starting to understand the interactions that nanoparticles undergo under more realistic situations...
October 6, 2016: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/27707735/when-clinical-heterogeneity-exceeds-genetic-heterogeneity-thinking-outside-the-genomic-box-in-chronic-myelomonocytic-leukemia
#3
Markus Ball, Alan F List, Eric Padron
Exome sequencing studies in Chronic Myelomonocytic Leukemia (CMML) illustrate a mutational landscape characterized by few somatic mutations involving a subset of recurrent gene mutations in ASXL1, SRSF2, and TET2, each approaching 40% in incidence. This has led to the clinical implementation of next generation sequencing panels that effectively identify clonal monocytosis and complement clinical prognostic scoring systems in most patients. However, most murine models based on single gene mutations fail to recapitulate the CMML phenotype and many gene mutations are loss-of-function making the identification of traditional therapeutic vulnerabilities challenging...
October 5, 2016: Blood
https://www.readbyqxmd.com/read/27680980/pre-emptive-antibiotic-therapy-to-reduce-ventilator-associated-pneumonia-thinking-outside-the-box
#4
Donald E Craven, Jana Hudcova, Yuxiu Lei, Kathleen A Craven, Ahsan Waqas
Mechanically ventilated, intubated patients are at increased risk for tracheal colonization with bacterial pathogens that may progress to heavy bacterial colonization, ventilator-associated tracheobronchitis (VAT), and/or ventilator-associated pneumonia (VAP). Previous studies report that 10 to 30 % of patients with VAT progress to VAP, resulting in increased morbidity and significant acute and chronic healthcare costs. Several natural history studies, randomized, controlled trials, and a meta-analysis have reported antibiotic treatment for VAT can reduce VAP, ventilator days, length of intensive care unit (ICU) stay, and patient morbidity and mortality...
September 29, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27650173/think-outside-the-box-acanthamoeba-encephalitis-following-autologous-haematopoietic-stem-cell-transplantation
#5
Narendranath Epperla, Horatiu Olteanu, Mehdi Hamadani
No abstract text is available yet for this article.
September 21, 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27648418/socio-cultural-factors-in-the-access-of-women-to-hiv-aids-prevention-and-treatment-services-in-south-southern-nigeria
#6
Edlyne Anugwom, Kenechukwu Anugwom
BACKGROUND: The South-southern zone of Nigeria is one of the zones in the country that has reported consistent high prevalent rates of HIV/AIDS pandemic in the last decade. In spite of bio-medical reasons adduced for the spread of the pandemic, socio-cultural factors may be major issues in the access to both prevention and treatment services especially for women. Hence, this study investigated the socio-cultural factors, which influence the access of women to HIV/AIDS prevention and treatment services in Nigeria...
June 2016: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/27567402/editorial-overview-antimicrobials-fighting-bacterial-infections-in-the-21st-century-thinking-outside-of-the-box
#7
Michael J Pucci, Thomas J Dougherty
No abstract text is available yet for this article.
October 2016: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/27530191/thinking-outside-the-box-use-of-the-pressure-wire-to-assess-intracranial-large-artery-stenoses
#8
EDITORIAL
Vani P Sanon, Anand Prasad
A novel study investigating the utility of the 0.014″ diameter pressure wire to assess the hemodynamic significance of intermediate intracranial stenosis. Technical aspects of pressure wire positioning across intracranial arteries are described. Further research is required to clarify the assessment of pressure gradients in the cerebral circulation and to define the optimal threshold for intervention.
August 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27512156/total-radiosynthesis-thinking-outside-the-box
#9
Steven H Liang, Neil Vasdev
The logic of total synthesis transformed a stagnant state of medicinal and synthetic organic chemistry when there was a paucity of methods and reagents to synthesize drug molecules and/or natural products. Molecular imaging by positron emission tomography (PET) is now experiencing a renaissance in the way radiopharmaceuticals for molecular imaging are synthesized, however, a paradigm shift is desperately needed in the discovery pipeline to accelerate in vivo imaging studies. A significant challenge in radiochemistry is the limited choice of labeled reagents (or building blocks) available for the synthesis of novel radiopharmaceuticals with the most commonly used short-lived radionuclides carbon-11 ((11)C; half-life ~20 minutes) and fluorine-18 ((18)F; half-life ~2 hours)...
September 2015: Australian Journal of Chemistry
https://www.readbyqxmd.com/read/27510424/thinking-outside-the-box-orbitofrontal-cortex-imagination-and-how-we-can-treat-addiction
#10
REVIEW
Geoffrey Schoenbaum, Chun-Yun Chang, Federica Lucantonio, Yuji K Takahashi
Addiction involves an inability to control drug-seeking behavior. While this may be thought of as secondary to an overwhelming desire for drugs, it could equally well reflect a failure of the brain mechanisms that allow addicts to learn about and mentally simulate non-drug consequences. Importantly, this process of mental simulation draws upon, but is not normally bound by, our past experiences. Rather we have the ability to think outside the box of our past, integrating knowledge gained from a variety of similar and not-so-similar life experiences to derive estimates or imagine what might happen next...
December 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27458751/representational-account-of-memory-insights-from-aging-and-synesthesia
#11
Gaby Pfeifer, Jamie Ward, Dennis Chan, Natasha Sigala
The representational account of memory envisages perception and memory to be on a continuum rather than in discretely divided brain systems [Bussey, T. J., & Saksida, L. M. Memory, perception, and the ventral visual-perirhinal-hippocampal stream: Thinking outside of the boxes. Hippocampus, 17, 898-908, 2007]. We tested this account using a novel between-group design with young grapheme-color synesthetes, older adults, and young controls. We investigated how the disparate sensory-perceptual abilities between these groups translated into associative memory performance for visual stimuli that do not induce synesthesia...
July 26, 2016: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/27456621/the-immune-pathogenesis-of-type-1-diabetes-not-only-thinking-outside-the-cell-but-also-outside-the-islet-and-out-of-the-box
#12
Hemmo A Drexhage, Wim A Dik, Pieter J M Leenen, Marjan A Versnel
No abstract text is available yet for this article.
August 2016: Diabetes
https://www.readbyqxmd.com/read/27453984/global-forum-2015-dialogue-on-from-evidence-to-policy-thinking-outside-the-box-perspectives-to-improve-evidence-uptake-and-good-practices-in-the-african-region
#13
Joses Muthuri Kirigia, Charles Ok Pannenborg, Luis Gabriel Cuervo Amore, Hassen Ghannem, Carel IJsselmuiden, Juliet Nabyonga-Orem
BACKGROUND: The Global Forum 2015 panel session dialogue entitled "From evidence to policy - thinking outside the box" was held on 26 August 2015 in the Philippines to debate why evidence was not fully translated into policy and practice and what could be done to increase its uptake. This paper reports the reasons and possible actions for increasing the uptake of evidence, and highlights the actions partners could take to increase the use of evidence in the African Region. DISCUSSION: The Global Forum 2015 debate attributed African Region's low uptake of evidence to the big gap in incentives and interests between research for health researchers and public health policy-makers; limited appreciation on the side of researchers that public health decisions are based on multiple and complex considerations; perception among users that research evidence is not relevant to local contexts; absence of knowledge translation platforms; sub-optimal collaboration and engagement between industry and research institutions; lack of involvement of civil society organizations; lack of engagement of communities in the research process; failure to engage the media; limited awareness and debate in national and local parliaments on the importance of investing in research and innovation; and dearth of research and innovation parks in the African Region...
2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27433408/systemic-mastocytosis-as-an-unconventional-cause-of-variceal-bleeding-think-outside-the-box
#14
Moiz Ahmed, Mayurathan Kesavan, Basmah N Jilani, Saba Ahmed, Liliane Deeb
Systemic mastocytosis is a rare infiltrative disease involving the skin, bone marrow, digestive system, and liver. We report a case of a 59-year-old male who presented with a massive variceal bleed without any evidence of cirrhosis; however was later found to have severe perisinusoidal fibrosis with mast cells in portal tracts on liver biopsy and hypercellular mast cell infiltrated bone marrow. This rare case describes an out-of-the-ordinary reason of variceal bleeding with preserved liver function due to non-cirrhotic portal hypertension...
2016: Curēus
https://www.readbyqxmd.com/read/27372957/training-in-perioperative-echocardiography-time-to-think-outside-the-box
#15
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
July 2016: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/27369026/engaging-critically-ill-patients-in-symptom-management-thinking-outside-the-box
#16
Linda L Chlan
Caring for critically ill patients receiving mechanical ventilation in the intensive care unit (ICU) is an immense challenge for clinicians. Interventions to maintain physiological stability and life itself can cause a number of adverse effects that have a marked impact on patients beyond the period of critical illness or injury. These ICU-acquired conditions include but are not limited to weakness, depression, and post-intensive care syndrome, all of which markedly affect patients' quality of life after they leave the unit...
July 2016: American Journal of Critical Care: An Official Publication, American Association of Critical-Care Nurses
https://www.readbyqxmd.com/read/27290875/thinking-outside-the-box
#17
Jo Killingley
No abstract text is available yet for this article.
2016: Midwives
https://www.readbyqxmd.com/read/27246532/engineering-bacteriophage-for-a-pragmatic-low-resource-setting-bacterial-diagnostic-platform
#18
COMMENT
Joey N Talbert, Samuel D Alcaine, Sam R Nugen
Bacteriophages represent multifaceted building blocks that can be incorporated as substitutes for, or in unison with other detection methods, to create powerful new diagnostics for the detection of bacteria. The ease of phage manipulation, production, and detection speed clearly highlights that there remains unrealized opportunities to leverage these phage-based components in diagnostics amenable to resource-limited settings. The passage of regulations like the Food Safety Modernization act, and the ever increasing extent of global trade and travel, will create further demand for these types of diagnostics...
April 2016: Bioengineered
https://www.readbyqxmd.com/read/27240027/thinking-outside-of-the-box-transfer-of-shape-based-reorientation-across-the-boundary-of-an-arena
#19
Matthew G Buckley, Alastair D Smith, Mark Haselgrove
The way in which human and non-human animals represent the shape of their environments remains a contentious issue. According to local theories of shape learning, organisms encode the local geometric features of the environment that signal a goal location. In contrast, global theories of shape learning suggest that organisms encode the overall shape of the environment. There is, however, a surprising lack of evidence to support this latter claim, despite the fact that common behaviours seem to require encoding of the global-shape of an environment...
June 2016: Cognitive Psychology
https://www.readbyqxmd.com/read/27194248/thinking-outside-the-box-re-evaluating-the-approach-to-penetrating-cardiac-injuries
#20
E W Stranch, B L Zarzaur, S A Savage
INTRODUCTION: Penetrating cardiac injuries are infrequent but highly lethal. To address these injuries, cardiopulmonary bypass and cardiothoracic surgery availability are required for Level I trauma center verification. However, acute care surgeons are more readily available for this time-sensitive injury. The purpose of this study was to review an acute care surgery-based experience with penetrating cardiac trauma at an urban Level 1 trauma center. Our hypothesis was that care provided solely by acute care surgeons was both safe and effective for this patient population...
May 18, 2016: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
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