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https://www.readbyqxmd.com/read/29749583/il-35-a-new-immunomodulator-in-autoimmune-rheumatic-diseases
#1
REVIEW
Lazaros I Sakkas, Athanasios Mavropoulos, Carlo Perricone, Dimitrios P Bogdanos
IL-35 is a relatively new cytokine that emerges as an important immunomodulator. IL-35 belongs to IL-12 cytokine family that includes IL-12, IL-23, IL-27, and IL-35. These cytokines are heterodimers that share subunits and their receptors also share subunits. Whereas IL-12 and IL-23 are clearly proinflammatory cytokines, the role of IL-35 is less clear. In mice, IL-35 appears to be anti-inflammatory and to protect from autoimmune inflammatory diseases. IL-35 induces the expansion of a subset of regulatory T cells (Tregs) and Bregs and mediates their suppressive function and inhibits Th17 cells...
May 11, 2018: Immunologic Research
https://www.readbyqxmd.com/read/29611775/upregulated-il-1-receptor-associated-kinase-1-irak1-in-systemic-lupus-erythematosus-irak1-inhibition-represses-th17-differentiation-with-therapeutic-potential
#2
Zhou Zhou, Zhiqiang Tian, Mengjie Zhang, Yuxun Zhang, Bing Ni, Fei Hao
Systemic lupus erythematosus (SLE) is a typical autoimmune disease. Genome-wide analyses have revealed that interleukin-1 receptor-associated kinase 1 (IRAK1) is associated with susceptibility to SLE. Our previous study investigated the role of IRAK1 in nuclear factor-κB (NF-κB)-related pathways in a mouse model of lupus. In this study, we aimed to further explore the etiological role of IRAK1. The gene expression and phosphorylation of IRAK1 in CD4+ T cells from lupus patients and healthy controls were examined by quantitative reverse transcription-polymerase chain reaction and western blotting, respectively...
April 3, 2018: Immunological Investigations
https://www.readbyqxmd.com/read/29557072/correlation-between-il-17a-f-il-23-il-35-and-il-12-23-p40-levels-in-peripheral-blood-lymphocyte-cultures-and-disease-activity-in-behcet-s-patients
#3
Cemile Sonmez, Aysegul Atak Yucel, Turan Hilmi Yesil, Hamit Kucuk, Berna Sezgin, Ridvan Mercan, Ahmet Eftal Yucel, Gulderen Yanikkaya Demirel
Behcet's disease is a chronic multisystemic disease with remissions and relapses. Several studies have shown that immune mechanisms play an important role in the development of the disease. In order to assess the association of disease activity with IL-17A/F, IL-23, IL-12/23 (p40) and IL-35 expression, we aimed to investigate production of these cytokines in peripheral blood mononuclear cells (PBMCs) from Behcet's patients and normal controls. Furthermore, we included Systemic Lupus Erythematosus (SLE) as disease control to evaluate the specificity of our data for immunopathogenesis of BD...
March 20, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/28887660/urinary-interleukin-22-binding-protein-as-a-marker-of-lupus-nephritis-in-egyptian-children-with-juvenile-systemic-lupus-erythematosus
#4
Ahmed Mohamed Mahmoud Badr, Yomna Farag, Maie Abdelshafy, Nermine Magdi Riad
Juvenile systemic lupus erythematosus (JSLE) is a multi-system autoimmune inflammatory disease. Generally, 60% of patients will develop lupus nephritis (LN); thus, early recognition and treatment is associated with better outcome. Interleukin 22 (IL-22) is involved in tissue inflammation and is regulated by interleukin 22 binding protein (IL-22BP). This study aimed to use IL-22BP as a non-invasive marker for disease activity in JSLE and LN. This is a cross-sectional study conducted on 82 subjects: 51 JSLE patients and 31 healthy controls of matched age and gender...
February 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/28646040/il-23-limits-the-production-of-il-2-and-promotes-autoimmunity-in-lupus
#5
Hong Dai, Fan He, George C Tsokos, Vasileios C Kyttaris
The IL-23/IL-17 pathway is important in multiple autoimmune diseases, but its effect on lupus pathology remains unclear, with opposing trials in murine models of the disease. In this study, we show a disease activity-related upregulation of serum IL-23 and IL-23 receptor in patients with systemic lupus erythematosus (SLE) as compared with healthy controls. When added in SLE T cell in vitro cultures, IL-23 induced IL-17 and limited IL-2 production, whereas T follicular helper and double negative (DN) T cells significantly expanded...
August 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28619037/ifn-%C3%AE-1-with-th17-axis-cytokines-and-ifn-%C3%AE-define-different-subsets-in-systemic-lupus-erythematosus-sle
#6
Vilija Oke, Susanna Brauner, Anders Larsson, Johanna Gustafsson, Agneta Zickert, Iva Gunnarsson, Elisabet Svenungsson
BACKGROUND: Interferon (IFN)-α is thought to have a pivotal role in systemic lupus erythematosus (SLE), and type III IFNs (IFN-λ) were recently also associated with SLE. In this study, we measured levels of IFN-α, IFN-λ1, and related cytokines, such as IL-17A, IL-23, and interferon-γ-induced protein 10 (IP-10), in a Karolinska University Hospital cohort of patients with SLE and control subjects. The objective of the study was to investigate if cytokine measurements could identify different subsets of patients with active SLE and higher disease damage...
June 15, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28298837/a-study-of-acute-muscle-dysfunction-with-particular-reference-to-dengue-myopathy
#7
Rajesh Verma, Vikram V Holla, Vijay Kumar, Amita Jain, Nuzhat Husain, Kiran Preet Malhotra, Ravindra Kumar Garg, Hardeep Singh Malhotra, Praveen Kumar Sharma, Neeraj Kumar
BACKGROUND: Acute myopathy is a common cause of acute motor quadriparesis which has various etiologies with different courses of illness and prognosis depending on the cause. Understanding this diversity helps us in proper approach toward diagnosis, predicting the prognosis, and possible complications and in improving the treatments that are being provided. This study was planned to study the clinical, electrophysiological, and etiological profile of patients presenting with acute myopathy...
January 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28263097/transcriptional-and-epigenetic-regulation-of-follicular-t-helper-cells-and-their-role-in-autoimmunity
#8
REVIEW
Hong Qiu, Haijing Wu, Vera Chan, Chak-Sing Lau, Qianjin Lu
T-follicular helper (Tfh) cells are a specialized subset of T cells that provide help to B cells and promote the formation of germinal centers (GCs). Tfh cells transmit important signals to B cells that drive class switch recombination, somatic hyper-mutation, the generation of high-affinity antibodies, immunological memory and their differentiation into plasma cells or memory B cells in the GCs. Tfh-cell differentiation is regulated by the coordinated functions of distinct cytokines, including interleukin (IL)-6, IL-21, IL-12, IL-23, IL-2, IL-7 and transforming growth factor-β (TGF-β), as well as transcription factors, including B-cell lymphoma 6 protein (Bcl-6), Signal transducers and activators of transcription (STAT)1, STAT3, STAT4, B-cell activating transcription factor (Batf), interferon regulatory factor 4 (IRF4), v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog (C-Maf), T-cell-specific transcription factor 1 (TCF-1) and Achaete-scute homolog 2 (Acl2), which have been shown to form a complex transcriptional network...
March 2017: Autoimmunity
https://www.readbyqxmd.com/read/27996081/tolerogenic-probiotics-potential-immunoregulators-in-systemic-lupus-erythematosus
#9
REVIEW
Seyed-Alireza Esmaeili, Mahmoud Mahmoudi, Amir Abbas Momtazi, Amirhossein Sahebkar, Hassan Doulabi, Maryam Rastin
Probiotics are commensal or nonpathogenic microbes that colonize the gastrointestinal tract and confer beneficial effects on the host through several mechanisms such as competitive exclusion, anti-bacterial effects, and modulation of immune responses. There is growing evidence supporting the immunomodulatory ability of some probiotics. Several experimental and clinical studies have been shown beneficial effect of some probiotic bacteria, particularly Lactobacillus and Bifidobacteria strains, on inflammatory and autoimmune diseases...
August 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27927883/serum-25-oh-vitamin-d-level-in-treatment-na%C3%A3-ve-systemic-lupus-erythematosus-patients-relation-to-disease-activity-il-23-and-il-17
#10
COMPARATIVE STUDY
D Shahin, R M El-Farahaty, M E Houssen, S A Machaly, M Sallam, T O ElSaid, N O Neseem
Objectives The aim of this study was to assess the vitamin D status in treatment-naïve SLE patients and its association with clinical and laboratory markers of disease activity, including serum levels of IL-17 and IL-23. Methods Fifty-seven treatment-naïve SLE patients along with 42 matched controls were included. SLEDAI score was used to estimate disease activity. Serum levels of 25(OH) D, IL-17 and IL-23 were measured. Results The median level of 25(OH) D in SLE patients (40.8; 4-70 ng/ml) was significantly lower than in the controls (47; 25-93 ng/ml) ( P = 0...
August 2017: Lupus
https://www.readbyqxmd.com/read/27814627/oxidative-dna-and-mitochondrial-dna-change-in-patients-with-sle
#11
Hui-Ting Lee, Tsai-Hung Wu, Chen-Sung Lin, Chyou-Shen Lee, Siao-Cian Pan, Deh-Ming Chang, Yau-Huei Wei, Chang-Youh Tsai
We evaluated plasma IL-10, IFN-alpha, IL-23, IFN-gamma, IP-10, MCP-1, 8-OHdG, leukocyte mtDNA, serum anti-dsDNA antibodies and disease activity index (SLEDAI) in SLE patients. 93 patients (35 nephritis, 4 under dialysis, 5 under rituximab) and 50 healthy controls were recruited. Compared with healthy controls, SLE patients had higher IL-10, IFN-alpha, IL-23, IFN-gamma, IP-10 and MCP-1 ( p <0.05). High IFN-alpha ( p =0.031) and IP-10 ( p =0.026) correlated with high SLEDAI; high IFN-alpha ( p< 0.001), IL-23 ( p =0...
January 1, 2017: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/27320770/impact-of-the-il-17f-il-23-and-il-23r-on-susceptibility-and-phenotype-of-systemic-lupus-erythematosus
#12
Agnieszka Paradowska-Gorycka, Anna Sowinska, Barbara Stypinska, Malwina Katarzyna Grobelna, Marcela Walczyk, Marzena Olesinska, Piotr Piotrowski, Paweł Piotr Jagodziński
Systemic lupus erythematosus (SLE) is a disease characterized by excessive proinflammatory cytokine production and damage to multiple organ systems. To investigate the potential association between cytokine gene polymorphisms and SLE, we performed a case-control study based on Polish population. SLE patients and controls, were examined for IL-23A rs11171806 G/A and IL-23R (rs1884444 G/T, rs10489629 G/A) by TaqMan SNP genotyping assay, for IL-17F rs763780 A/G and rs2397084A/G using the PCR- RFLP method...
September 2016: Autoimmunity
https://www.readbyqxmd.com/read/27279980/effects-of-1-25-dihydroxyvitamin-d3-on-il-17-il-23-axis-ifn-%C3%AE-and-il-4-expression-in-systemic-lupus-erythematosus-induced-mice-model
#13
Fatemeh Faraji, Maryam Rastin, Fahimeh Lavi Arab, Mohammad Reza Kalantari, Shahrzad Zamani Taghizadeh Rabe, Nafise Tabasi, Mahmoud Mahmoudi
OBJECTIVES: Systemic lupus erythematosus (SLE) is a multi-factorial autoimmune disease which may be characterized by T lymphocytes dysfunctions. Th17 cells have been identified as new effector cells, which play an important role in the pathogenesis. In recent years, immunomodulatory effect of vitamin D3 has been noticed. In the present experiment, the effect of vitamin D3 on the expression of IL-17, IL-23, IL-4 and IFN-γ were assessed in activated chromatin-induced mouse model for SLE...
April 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27019190/a-novel-il-23p19-ebi3-il-39-cytokine-mediates-inflammation-in-lupus-like-mice
#14
Xiaoqian Wang, Yinxiang Wei, He Xiao, Xiaoling Liu, Yu Zhang, Gencheng Han, Guojiang Chen, Chunmei Hou, Ning Ma, Beifen Shen, Yan Li, Charles E Egwuagu, Renxi Wang
Interleukin-12 family cytokines have emerged as critical regulators of immunity with some members (IL-12, IL-23) associated with disease pathogenesis while others (IL-27, IL-35) mitigate autoimmune diseases. Each IL-12 family member is comprised of an α and a β chain, and chain-sharing is a key feature. Although four bona fide members have thus far been described, promiscuous chain-pairing between alpha (IL-23p19, IL-27p28, IL-12/IL-35p35) and beta (IL-12/IL-23p40, IL-27/IL-35Ebi3) subunits, predicts six possible heterodimeric IL-12 family cytokines...
June 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/26507122/human-umbilical-cord-derived-mesenchymal-stem-cells-promote-interleukin-17-production-from-human-peripheral-blood-mononuclear-cells-of-healthy-donors-and-systemic-lupus-erythematosus-patients
#15
S Ren, J Hu, Y Chen, T Yuan, H Hu, S Li
Inflammation instigated by interleukin (IL)-17-producing cells is central to the development and pathogenesis of several human autoimmune diseases and animal models of autoimmunity. The expansion of IL-17-producing cells from healthy donors is reportedly promoted by mesenchymal stem cells derived from fetal bone marrow. In the present study, human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) were examined for their effects on lymphocytes from healthy donors and from patients with systemic lupus erythematosus (SLE)...
March 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/26474696/a-truncated-il-12r%C3%AE-1-receptor-ameliorates-chronic-graft-versus-host-disease-induced-lupus-nephritis-by-inhibiting-th1-and-th17-cells
#16
Chen Wang, Wei Guo, Di Cai, Xin Wang, Dongmei Yu, Xiangdong Gao, Wenbing Yao
Th1 and Th17 cells have been strongly implicated in the pathogenesis of systemic lupus erythematosus (SLE). Interleukin (IL)-12 and IL-23 respectively drive the polarization of Th1 and Th17 cells and share a common p40 subunit. In this study, the protective and therapeutic effects of a truncated human IL-12rβ1 receptor (tIL12rβ1) targeting IL-12/IL-23 p40 were evaluated in chronic graft-versus-host disease (cGVHD)-induced SLE-like model. The results indicated that tIL12rβ1 treatment effectively delayed the proteinuria onset and induced a significant remission of proteinuria, autoantibody production, and immune complex deposition in the mouse model...
December 2015: International Immunopharmacology
https://www.readbyqxmd.com/read/26314292/elevated-il-1%C3%AE-levels-in-anti-ro-ssa-connective-tissue-diseases-patients-with-prolonged-corrected-qtc-interval
#17
Cecilia N Pisoni, Silvia Reina, Diego Arakaki, Alicia Eimon, Carolina Carrizo, Enri Borda
OBJECTIVES: Patients with systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (pSS) have increased IL-1β levels. IL-1β and other pro-inflammatory cytokines have a modulating activity on cardiac ion channels and have been associated with increased arrhythmic risk in rheumatoid arthritis patients. Likewise, adult patients with connective tissue diseases (CTDs) may have prolonged QTc intervals associated with the presence of anti-Ro/SSA antibodies. Our objective was to evaluate the presence of serum IL-1β in subjects with CTDs, in relation to the presence of anti-Ro/SSA antibodies and QTc interval duration...
September 2015: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/26119191/influence-of-1-alpha-25-dihydroxyvitamin-d3-on-t-helper-17-cells-and-related-cytokines-in-systemic-lupus-erythematosus
#18
Hadi Reihani, Maryam Rastin, Mahmoud Mahmoudi, Mohsen Ghoryani, Nafiseh Abdollahi, Nafiseh Sadat Tabasi, Shahrzad Zamani Taghizadeh Rabe, Maryam Sahebari
BACKGROUND: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. Emerging data suggests that T helper 17 (Th17) cells play a pathogenic role in SLE and the increased number of these cells correlates with disease activity. In recent years, 1α, 25-dihydroxyvitamin D3 (1,25VitD3) has been considered as an immunomodulatory factor. OBJECTIVE: To investigate the effect of 1,25VitD3 on Th17 cells and on the expression of related cytokines in SLE patients...
June 2015: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/25939522/role-of-il-17-in-the-pathogenesis-of-psoriatic-arthritis-and-axial-spondyloarthritis
#19
REVIEW
Smriti K Raychaudhuri, Ankit Saxena, Siba P Raychaudhuri
Th17 cells are a discrete subset of T cell subpopulation, which produce IL-17 and certain other pro-inflammatory cytokines. A regulatory role of Th17 cells have been proposed in several autoimmune diseases including psoriasis, psoriatic arthritis (PsA), ankylosing spondylitis (AS), rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, and multiple sclerosis. Psoriatic disease is an autoimmune disease which mainly involves skin and joints. Until recently, psoriasis and PsA were thought to be Th1 mediated disease, but after the discovery of IL-17 and IL-17 knockout animal studies as well as human experimental data indicate a crucial role of the Th17 cells in the pathogenesis of psoriasis and PsA...
June 2015: Clinical Rheumatology
https://www.readbyqxmd.com/read/25647269/th1-th2-th17-treg-cytokine-imbalance-in-systemic-lupus-erythematosus-sle-patients-correlation-with-disease-activity
#20
Roba M Talaat, Sara F Mohamed, Iman H Bassyouni, Ahmed A Raouf
AIM: Imbalance of T-helper-cell (TH) subsets (TH1/TH2/TH17) and regulatory T-cells (Tregs) is suggested to contribute to the pathogenesis of Systemic lupus erythematosus (SLE). Therefore, we evaluated their cytokine secretion profile in SLE patients and their possible association with disease activity. METHODS: Sixty SLE patients, 24 rheumatoid arthritis (RA) patients and 24 healthy volunteers were included in this study. Demographic, clinical, disease activity and serological data were prospectively assessed...
April 2015: Cytokine
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