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Il-23 and sle

Agnieszka Paradowska-Gorycka, Anna Sowinska, Barbara Stypinska, M K Grobelna, Marcela Walczyk, Marzena Olesinska, Piotr Piotrowski, Pawe Piotr Jagodzinski
Systemic lupus erythematosus (SLE) is a disease characterized by excessive proinflammatory cytokine production and damage to multiple organ systems. To investigate the potential association between cytokine gene polymorphisms and SLE, we performed a case-control study based on Polish population. SLE patients and controls, were examined for IL-23A rs11171806 G/A and IL-23R (rs1884444 G/T, rs10489629 G/A) by TaqMan SNP genotyping assay, for IL-17F rs763780 A/G and rs2397084A/G using the PCR- RFLP method...
June 19, 2016: Autoimmunity
Fatemeh Faraji, Maryam Rastin, Fahimeh Lavi Arab, Mohammad Reza Kalantari, Shahrzad Zamani Taghizadeh Rabe, Nafise Tabasi, Mahmoud Mahmoudi
OBJECTIVES: Systemic lupus erythematosus (SLE) is a multi-factorial autoimmune disease which may be characterized by T lymphocytes dysfunctions. Th17 cells have been identified as new effector cells, which play an important role in the pathogenesis. In recent years, immunomodulatory effect of vitamin D3 has been noticed. In the present experiment, the effect of vitamin D3 on the expression of IL-17, IL-23, IL-4 and IFN-γ were assessed in activated chromatin-induced mouse model for SLE...
April 2016: Iranian Journal of Basic Medical Sciences
Xiaoqian Wang, Yinxiang Wei, He Xiao, Xiaoling Liu, Yu Zhang, Gencheng Han, Guojiang Chen, Chunmei Hou, Ning Ma, Beifen Shen, Yan Li, Charles E Egwuagu, Renxi Wang
Interleukin-12 family cytokines have emerged as critical regulators of immunity with some members (IL-12, IL-23) associated with disease pathogenesis while others (IL-27, IL-35) mitigate autoimmune diseases. Each IL-12 family member is comprised of an α and a β chain, and chain-sharing is a key feature. Although four bona fide members have thus far been described, promiscuous chain-pairing between alpha (IL-23p19, IL-27p28, IL-12/IL-35p35) and beta (IL-12/IL-23p40, IL-27/IL-35Ebi3) subunits, predicts six possible heterodimeric IL-12 family cytokines...
June 2016: European Journal of Immunology
S Ren, J Hu, Y Chen, T Yuan, H Hu, S Li
Inflammation instigated by interleukin (IL)-17-producing cells is central to the development and pathogenesis of several human autoimmune diseases and animal models of autoimmunity. The expansion of IL-17-producing cells from healthy donors is reportedly promoted by mesenchymal stem cells derived from fetal bone marrow. In the present study, human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) were examined for their effects on lymphocytes from healthy donors and from patients with systemic lupus erythematosus (SLE)...
March 2016: Clinical and Experimental Immunology
Chen Wang, Wei Guo, Di Cai, Xin Wang, Dongmei Yu, Xiangdong Gao, Wenbing Yao
Th1 and Th17 cells have been strongly implicated in the pathogenesis of systemic lupus erythematosus (SLE). Interleukin (IL)-12 and IL-23 respectively drive the polarization of Th1 and Th17 cells and share a common p40 subunit. In this study, the protective and therapeutic effects of a truncated human IL-12rβ1 receptor (tIL12rβ1) targeting IL-12/IL-23 p40 were evaluated in chronic graft-versus-host disease (cGVHD)-induced SLE-like model. The results indicated that tIL12rβ1 treatment effectively delayed the proteinuria onset and induced a significant remission of proteinuria, autoantibody production, and immune complex deposition in the mouse model...
December 2015: International Immunopharmacology
Cecilia N Pisoni, Silvia Reina, Diego Arakaki, Alicia Eimon, Carolina Carrizo, Enri Borda
OBJECTIVES: Patients with systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (pSS) have increased IL-1β levels. IL-1β and other pro-inflammatory cytokines have a modulating activity on cardiac ion channels and have been associated with increased arrhythmic risk in rheumatoid arthritis patients. Likewise, adult patients with connective tissue diseases (CTDs) may have prolonged QTc intervals associated with the presence of anti-Ro/SSA antibodies. Our objective was to evaluate the presence of serum IL-1β in subjects with CTDs, in relation to the presence of anti-Ro/SSA antibodies and QTc interval duration...
September 2015: Clinical and Experimental Rheumatology
Hadi Reihani, Maryam Rastin, Mahmoud Mahmoudi, Mohsen Ghoryani, Nafiseh Abdollahi, Nafiseh Sadat Tabasi, Shahrzad Zamani Taghizadeh Rabe, Maryam Sahebari
BACKGROUND: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. Emerging data suggests that T helper 17 (Th17) cells play a pathogenic role in SLE and the increased number of these cells correlates with disease activity. In recent years, 1α, 25-dihydroxyvitamin D3 (1,25VitD3) has been considered as an immunomodulatory factor. OBJECTIVE: To investigate the effect of 1,25VitD3 on Th17 cells and on the expression of related cytokines in SLE patients...
June 2015: Iranian Journal of Immunology: IJI
Smriti K Raychaudhuri, Ankit Saxena, Siba P Raychaudhuri
Th17 cells are a discrete subset of T cell subpopulation, which produce IL-17 and certain other pro-inflammatory cytokines. A regulatory role of Th17 cells have been proposed in several autoimmune diseases including psoriasis, psoriatic arthritis (PsA), ankylosing spondylitis (AS), rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, and multiple sclerosis. Psoriatic disease is an autoimmune disease which mainly involves skin and joints. Until recently, psoriasis and PsA were thought to be Th1 mediated disease, but after the discovery of IL-17 and IL-17 knockout animal studies as well as human experimental data indicate a crucial role of the Th17 cells in the pathogenesis of psoriasis and PsA...
June 2015: Clinical Rheumatology
Roba M Talaat, Sara F Mohamed, Iman H Bassyouni, Ahmed A Raouf
AIM: Imbalance of T-helper-cell (TH) subsets (TH1/TH2/TH17) and regulatory T-cells (Tregs) is suggested to contribute to the pathogenesis of Systemic lupus erythematosus (SLE). Therefore, we evaluated their cytokine secretion profile in SLE patients and their possible association with disease activity. METHODS: Sixty SLE patients, 24 rheumatoid arthritis (RA) patients and 24 healthy volunteers were included in this study. Demographic, clinical, disease activity and serological data were prospectively assessed...
April 2015: Cytokine
L P Xia, B F Li, H Shen, J Lu
OBJECTIVES: To analyse the concentration of interleukin (IL)-27 and IL-23 in serum and urine of patients with systemic lupus erythematosus (SLE) compared with healthy controls (HC). METHOD: An enzyme-linked immunosorbent assay (ELISA) was used to analyse the serum and urine concentration of IL-27 and IL-23 from 50 patients with lupus nephritis (LN), 55 patients without LN, and 30 HC. The correlations between the levels of IL-27, IL-23, and disease activity, clinical parameters in SLE patients were analysed...
May 2015: Scandinavian Journal of Rheumatology
Jonathan P Sherlock, Peter C Taylor, Christopher D Buckley
PURPOSE OF REVIEW: Interleukin (IL)-23 and the related cytokine IL-17 play vital roles in immune-mediated inflammatory pathology. In the years since its discovery, IL-23 has been implicated as a central pathogenic factor in multiple rheumatic conditions and has been shown to act via a wide range of immune cells including type 17 T-helper (Th17) cells and innate-like immune cells. We review here the pivotal role of these cytokines and IL-23-responsive cells in both the bona fide autoimmune rheumatic diseases rheumatoid arthritis and systemic lupus erythematosus, as well as the spondyloarthropathies which more closely resemble the auto-inflammatory conditions...
January 2015: Current Opinion in Rheumatology
Daniel J Wallace, Igor M Gavin, Oleksly Karpenko, Farnaz Barkhordar, Bruce S Gillis
Making a correct diagnosis is pivotal in the practice of clinical rheumatology. Occasionally, the consultation fails to provide desired clarity in making labeling an individual as having fibromyalgia (FM), systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA). A chemokine and cytokine multiplex assay was developed and tested with the goal of improving and achieving an accurate differential diagnosis. 160 patients with FM, 98 with RA and 100 with SLE fulfilling accepted criteria were recruited and compared to 119 controls...
June 2015: Rheumatology International
Claudia Azucena Palafox-Sánchez, Edith Oregon-Romero, Diana Celeste Salazar-Camarena, Yeminia Maribel Valle, Jesús René Machado-Contreras, Alvaro Cruz, Mariana Orozco-López, Gerardo Orozco-Barocio, Mónica Vázquez-Del Mercado, José Francisco Muñoz-Valle
Systemic lupus erythematosus (SLE) is the prototype autoimmune rheumatic disease. The etiology of this disease is incompletely understood; however, environmental factors and genetic predisposition are involved. Cytokine-mediated immunity plays a crucial role in the pathogenesis of SLE. We investigate the association of interleukin-10 (IL-10) promoter polymorphisms and their haplotypes in SLE patients from the western Mexico. One hundred and twenty-five SLE patients fulfilling the 1997 ACR criteria and 260 unrelated healthy subjects (HS), both Mexican mestizos, were genotyped for IL-10 -1082A>G, -819C>T, and -592C>A polymorphisms...
November 2015: Clinical and Experimental Medicine
Li Wang, Pingwei Zhao, Liang Ma, Yuxing Shan, Zhenyu Jiang, Juan Wang, Yanfang Jiang
OBJECTIVE: To elucidate the potential role of follicular helper T cells (TFH) and interleukin 10 (IL-10)+ B cells in the development of systemic lupus erythematosus (SLE). METHODS: The numbers of peripheral blood CD27+, CD38+, CD86+, CD95+, IL-10+ B cells, and inducible T cell costimulator (ICOS)+, programmed death-1 (PD-1)+, IL-21+, CXCR5+CD4+ TFH-like cells were examined in 23 patients with new onset SLE and 20 healthy controls (HC). RESULTS: In comparison with HC, significantly reduced numbers of CD19+ and IL-10+ B cells, but increased numbers of CD27(high), CD86+, CD95+ B cells, CXCR5+CD4+, ICOS+, PD-1+, and IL-21+ TFH-like cells were detected, which were accompanied by higher levels of serum IL-21, but lower levels of IL-10 in the patients...
September 2014: Journal of Rheumatology
Juan Du, Zongshu Li, Jingwei Shi, Liqi Bi
OBJECTIVE: To analyse the association between serum interleukin (IL)-23 mRNA levels and clinical characteristics in patients with systemic lupus erythematosus (SLE). METHODS: Serum IL-23 and IL-17 mRNA levels were quantified using real-time reverse transcription-polymerase chain reaction in patients with SLE and healthy controls. Disease activity was assessed using the SLE Disease Activity Index-2k. RESULTS: A total of 108 patients with SLE and 60 control subjects were recruited...
October 2014: Journal of International Medical Research
Magdalena Szmyrka-Kaczmarek, Agata Kosmaczewska, Lidia Ciszak, Aleksandra Szteblich, Piotr Wiland
INTRODUCTION: The balance between proinflammatory Th17 cells and regulatory T cells plays an important role in the pathogenesis of autoimmune diseases, including systemic lupus erythematosus (SLE). In particular, an increased ratio of Th17/Treg cells has been shown to correlate with active SLE and specific organ involvement. The aim of our study was to assess Th17 and Treg cell populations in peripheral blood (PB) of patients with clinically quiescent SLE, and to evaluate their correlation with organ involvement...
2014: Postȩpy Higieny i Medycyny Doświadczalnej
Jérôme C Martin, Dominique L Baeten, Régis Josien
Despite the success of targeted therapies in managing immune-mediated inflammatory diseases (IMIDs) such as RA, IBDs, MS and psoriasis, unmet needs for such approach in SLE are widely recognized. In the past 2years, exciting insights supporting previous lines of evidence on the role of the IL-23/IL-17 axis in SLE have emerged. This is of particular importance as IL-17 blockers have now moved successfully into the clinical space, as illustrated in psoriasis and ankylosing spondylitis. However, recent fundamental studies also highlighted unexpected aspects of IL-17/Th17 biology whose comprehension may prevent disappointing results of IL-17 targeting such as those obtained in Crohn's disease...
September 2014: Clinical Immunology: the Official Journal of the Clinical Immunology Society
Zhenke Wen, Lin Xu, Wei Xu, Sidong Xiong
Recent evidence implicated an important role of Th17 cells in the pathogenesis of systemic lupus erythematosus (SLE). However, the association between dynamic changes of Th17 cell frequency and clinical parameters in SLE patients receiving clinical managements remains unknown. Here, we sought to evaluate their correlation in Chinese new-onset SLE patients with standard therapy. We found that the frequency of Th17 cells was higher in SLE patients than that in healthy controls and could be decreased by standard care...
2014: Clinical Rheumatology
A L Barbulescu, F Vreju, I R Cojocaru-Gofita, A E Musetescu, P L Ciurea
BACKGROUND: Systemic lupus erythematosus (SLE) is an inflammatory disease caused by autoimmune dysregulation, which mainly affects young women, usually free from atherosclerosis. Accelerated atherosclerosis is a well established complication of SLE and it cannot be explained by Framingham risk factors alone, and has been attributed to complex interactions between traditional risk factors and factors associated with the disease per se, or its treatment. Arterial stiffness and endothelium function may serve as a valuable measure to be counted in the follow-up of these patients prior to a potential cardiovascular event...
April 2012: Current Health Sciences Journal
Yan Liang, Yan Zhu, Yi Xia, Hui Peng, Xiao-Ke Yang, Yan-Yan Liu, Wang-Dong Xu, Hai-Feng Pan, Dong-Qing Ye
INTRODUCTION: Tyrosine kinase 2 (Tyk2) is a Janus kinase family member that is crucial for signaling transduction in response to a wide variety of cytokines, including type I IFNs, IL-6, IL-10, IL-12 and IL-23. An appropriate expression of Tyk2-mediated signaling might be essential for maintaining normal immune responses. AREAS COVERED: This review summarizes that Tyk2 is essential for the differentiation and function of a wide variety of immune cells, including natural killer cells, B cells, as well as T helper cells...
May 2014: Expert Opinion on Therapeutic Targets
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