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JOURNAL ARTICLE
Xinbo Wang, Javier Espadas, Yumei Wu, Shujun Cai, Jinghua Ge, Lin Shao, Aurélien Roux, Pietro De Camilli
Mutations in Leucine-rich repeat kinase 2 (LRRK2) are responsible for late-onset autosomal dominant Parkinson's disease. LRRK2 has been implicated in a wide range of physiological processes including membrane repair in the endolysosomal system. Here, using cell-free systems, we report that purified LRRK2 directly binds acidic lipid bilayers with a preference for highly curved bilayers. While this binding is nucleotide independent, LRRK2 can also deform low-curvature liposomes into narrow tubules in a guanylnucleotide-dependent but Adenosine 5'-triphosphate-independent way...
October 24, 2023: Proceedings of the National Academy of Sciences of the United States of America
#22
REVIEW
Irma Bisceglia, Maria Laura Canale, Nicola Silvestris, Giuseppina Gallucci, Andrea Camerini, Alessandro Inno, Massimiliano Camilli, Fabio Maria Turazza, Giulia Russo, Andrea Paccone, Raffaella Mistrulli, Leonardo De Luca, Stefania Angela Di Fusco, Luigi Tarantini, Fabiana Lucà, Stefano Oliva, Antonella Moreo, Nicola Maurea, Vincenzo Quagliariello, Giuseppina Rosaria Ricciardi, Chiara Lestuzzi, Damiana Fiscella, Iris Parrini, Vito Racanelli, Antonio Russo, Lorena Incorvaia, Fabio Calabrò, Giuseppe Curigliano, Saverio Cinieri, Michele Massimo Gulizia, Domenico Gabrielli, Fabrizio Oliva, Furio Colivicchi
In cancer, a patient is considered a survivor from the time of initial diagnosis until the end of life. With improvements in early diagnosis and treatment, the number of cancer survivors (CS) has grown considerably and includes: (1) Patients cured and free from cancer who may be at risk of late-onset cancer therapy-related cardiovascular toxicity (CTR-CVT); (2) Patients with long-term control of not-curable cancers in whom CTR-CVT may need to be addressed. This paper highlights the importance of the cancer care continuum, of a patient-centered approach and of a prevention-oriented policy...
2023: Frontiers in Cardiovascular Medicine
#23
REVIEW
Mariia Ivanova, Francesca Maria Porta, Marianna D'Ercole, Carlo Pescia, Elham Sajjadi, Giulia Cursano, Elisa De Camilli, Oriana Pala, Giovanni Mazzarol, Konstantinos Venetis, Elena Guerini-Rocco, Giuseppe Curigliano, Giuseppe Viale, Nicola Fusco
Since the release of the DESTINY-Breast04 (DB-04) trial findings in June 2022, the field of pathology has seen a renaissance of HER2 as a predictive biomarker in breast cancer. The trial focused on patients with metastatic breast cancer who were classified as "HER2-low," i.e., those with immunohistochemistry (IHC) HER2 1 + or 2 + and negative in situ hybridization (ISH) results. The study revealed that treating these patients with trastuzumab deruxtecan (T-DXd) instead of the oncologist's chosen chemotherapy led to outstanding improvements in survival...
September 28, 2023: Virchows Archiv: An International Journal of Pathology
#24
JOURNAL ARTICLE
Moema de Alencar Hausen, Ariana de Souza Moraes, Flavia Pedrini, Felipe Grabarz, José Angelo Camilli, Eliana Aparecida de Rezende Duek
The skin, the human body's largest organ, possesses a protective barrier that renders it susceptible to various injuries, including burns. Following burn trauma, the inflammatory process triggers both innate and adaptive immune responses, leading to the polarization of macrophages into two distinct phenotypes: the pro-inflammatory M1 and the anti-inflammatory M2. This dual response sets the stage for wound healing and subsequent tissue regeneration. Contributing to this transition from M1 to M2 polarization are human adipose-derived stem cells (ASCs), which employ paracrine signaling and inflammation suppression to enhance the remodeling phase...
September 12, 2023: Macromolecular Bioscience
#25
REVIEW
Maria Alessia Zerella, Mattia Zaffaroni, Giuseppe Ronci, Samantha Dicuonzo, Damaris Patricia Rojas, Anna Morra, Marianna Alessandra Gerardi, Cristiana Fodor, Elena Rondi, Sabrina Vigorito, Silvia Penco, Manuela Sargenti, Paola Baratella, Elisa Vicini, Consuelo Morigi, Sabrina Kahler-Ribeiro-Fontana, Viviana Enrica Galimberti, Sara Gandini, Elisa De Camilli, Giuseppe Renne, Federica Cattani, Paolo Veronesi, Roberto Orecchia, Barbara Alicja Jereczek-Fossa, Maria Cristina Leonardi
The strategy to anticipate radiotherapy (RT) before surgery, for breast cancer (BC) treatment, has recently generated a renewed interest. Historically, preoperative RT has remained confined either to highly selected patients, in the context of personalized therapy, or to clinical research protocols. Nevertheless, in the recent years, thanks to technological advances and increased tumor biology understanding, RT has undergone great changes that have also impacted the preoperative settings, embracing the modern approach to breast cancer...
August 31, 2023: La Radiologia Medica
#26
REVIEW
Alessandro De Camilli, Gregory Fischer
Targeted cellular and immunotherapies have welcomed a new chapter in multi-modal cancer therapy. These agents harness our innate immune system and destroy malignant cells in a precise way as compared with "legacy" chemotherapeutic agents that largely rely on abolishing cell division. New therapies can augment the T-cell recognition of tumor antigens and effectively prevent tumor cells from their historically successful ability to evade immune recognition. These novel agents cause acute and chronic toxicities to a variety of organ systems (enteritis, pneumonitis, hypophysitis, and hepatitis), and this may masquerade as other chronic illnesses or paraneoplastic effects...
August 16, 2023: Current Oncology
#27
REVIEW
Nicola Fusco, Mariia Ivanova, Chiara Frascarelli, Carmen Criscitiello, Bruna Cerbelli, Maria Gemma Pignataro, Angelina Pernazza, Elham Sajjadi, Konstantinos Venetis, Giulia Cursano, Fabio Pagni, Camillo Di Bella, Marina Accardo, Michelina Amato, Paolo Amico, Caterina Bartoli, Giuseppe Bogina, Laura Bortesi, Renzo Boldorini, Sara Bruno, Daniela Cabibi, Pietro Caruana, Emanuele Dainese, Elisa De Camilli, Vladimiro Dell'Anna, Loren Duda, Carmela Emmanuele, Giuseppe Nicolò Fanelli, Bethania Fernandes, Gerardo Ferrara, Letizia Gnetti, Alessandra Gurrera, Giorgia Leone, Raffaella Lucci, Cristina Mancini, Grazia Marangi, Mauro G Mastropasqua, Lorenzo Nibid, Sandra Orrù, Maria Pastena, Monica Peresi, Letizia Perracchio, Angela Santoro, Vania Vezzosi, Claudia Zambelli, Valeria Zuccalà, Antonio Rizzo, Leopoldo Costarelli, Francesca Pietribiasi, Alfredo Santinelli, Cristian Scatena, Giuseppe Curigliano, Elena Guerini-Rocco, Maurizio Martini, Paolo Graziano, Isabella Castellano, Giulia d'Amati
Pembrolizumab has received approval as a first-line treatment for unresectable/metastatic triple-negative breast cancer (mTNBC) with a PD-L1 combined positive score (CPS) of ≥ 10. However, assessing CPS in mTNBC poses challenges. Firstly, it represents a novel analysis for breast pathologists. Secondly, the heterogeneity of PD-L1 expression in mTNBC further complicates the assessment. Lastly, the lack of standardized assays and staining platforms adds to the complexity. In KEYNOTE trials, PD-L1 expression was evaluated using the IHC 22C3 pharmDx kit as a companion diagnostic test...
August 16, 2023: Critical Reviews in Oncology/hematology
#28
JOURNAL ARTICLE
Junhyun Park, Yi Xie, Kenneth G Miller, Pietro De Camilli, Shaul Yogev
Axonal transport is key to neuronal function. Efficient transport requires specific motor-cargo association in the soma, yet the mechanisms regulating this early step remain poorly understood. We found that EBP-1, the C. elegans ortholog of the canonical-microtubule-end-binding protein EB1, promotes the specific association between kinesin-3/KIF1A/UNC-104 and dense core vesicles (DCVs) prior to their axonal delivery. Using single-neuron, in vivo labeling of endogenous cargo and EBs, we observed reduced axonal abundance and reduced secretion of DCV cargo, but not other KIF1A/UNC-104 cargoes, in ebp-1 mutants...
August 8, 2023: Current Biology: CB
#29
Elisa Pesce, Chiara Cordiglieri, Mauro Bombaci, Serenella Eppenberger-Castori, Stefania Oliveto, Cristina Manara, Mariacristina Crosti, Caner Ercan, Mairene Coto, Andrea Gobbini, Susanna Campagnoli, Tiziano Donnarumma, Manuele Martinelli, Valeria Bevilacqua, Elisa De Camilli, Paola Gruarin, Maria L Sarnicola, Elisa Cassinotti, Ludovica Baldari, Giuseppe Viale, Stefano Biffo, Sergio Abrignani, Luigi M Terracciano, Renata Grifantini
[This corrects the article DOI: 10.3389/fimmu.2023.1194087.].
2023: Frontiers in Immunology
#30
JOURNAL ARTICLE
Elisa Pesce, Chiara Cordiglieri, Mauro Bombaci, Serenella Eppenberger-Castori, Stefania Oliveto, Cristina Manara, Mariacristina Crosti, Caner Ercan, Mairene Coto, Andrea Gobbini, Susanna Campagnoli, Tiziano Donnarumma, Manuele Martinelli, Valeria Bevilacqua, Elisa De Camilli, Paola Gruarin, Maria L Sarnicola, Elisa Cassinotti, Ludovica Baldari, Giuseppe Viale, Stefano Biffo, Sergio Abrignani, Luigi M Terracciano, Renata Grifantini
Colorectal cancer (CRC) is a leading cause of cancer-associated death. In the tumor site, the interplay between effector immune cells and cancer cells determines the balance between tumor elimination or outgrowth. We discovered that the protein TMEM123 is over-expressed in tumour-infiltrating CD4 and CD8 T lymphocytes and it contributes to their effector phenotype. The presence of infiltrating TMEM123+ CD8+ T cells is associated with better overall and metastasis-free survival. TMEM123 localizes in the protrusions of infiltrating T cells, it contributes to lymphocyte migration and cytoskeleton organization...
2023: Frontiers in Immunology
#31
REVIEW
Michael Hanna, Andrés Guillén-Samander, Pietro De Camilli
The life of eukaryotic cells requires the transport of lipids between membranes, which are separated by the aqueous environment of the cytosol. Vesicle-mediated traffic along the secretory and endocytic pathways and lipid transfer proteins (LTPs) cooperate in this transport. Until recently, known LTPs were shown to carry one or a few lipids at a time and were thought to mediate transport by shuttle-like mechanisms. Over the last few years, a new family of LTPs has been discovered that is defined by a repeating β-groove (RBG) rod-like structure with a hydrophobic channel running along their entire length...
July 5, 2023: Annual Review of Cell and Developmental Biology
#32
JOURNAL ARTICLE
Alessia Armellini, Gianluigi Ferri, Carlotta Lauteri, Antonio De Camillis, Luca Pennisi
Microplastics (μPs) represent an emerging problem for the marine environment given their wide bioavailability for all aquatic organisms, from zooplankton to top predators. This work aimed to evaluate a method of extracting microplastics from the gastrointestinal tract of 122 Sepia officinalis caught from the Adriatic Sea (along Abruzzo region coasts) to measure its quantity in a poorly investigated species. The extraction method used for gastrointestinal content was performed using 10% potassium hydroxide...
June 8, 2023: Italian Journal of Food Safety
#33
JOURNAL ARTICLE
Elena De Angelis, Thomas Bochaton, Enrico Ammirati, Andrea Tedeschi, Maria Vincenza Polito, Maurizio Pieroni, Marco Merlo, Piero Gentile, Caroline M Van De Heyning, Thalia Bekelaar, Alberto Cipriani, Massimiliano Camilli, Tommaso Sanna, Martina Perazzolo Marra, Aderville Cabassi, Massimo F Piepoli, Gianfranco Sinagra, Nathan Mewton, Eric Bonnefoy-Cudraz, Amelia Ravera, Ahmad Hayek
OBJECTIVE: There is still uncertainty about the management of patients with pheochromocytoma-induced cardiogenic shock (PICS). This study aims to investigate the clinical presentation, management, and outcome of patients with PICS. METHODS: We collected, retrospectively, the data of 18 patients without previously known pheochromocytoma admitted to 8 European hospitals with a diagnosis of PICS. RESULTS: Among the 18 patients with a median age of 50 years (Q1-Q3: 40-61), 50% were men...
May 8, 2023: International Journal of Cardiology
#34
JOURNAL ARTICLE
Taryn J Olivas, Yumei Wu, Shenliang Yu, Lin Luan, Peter Choi, Emily D Guinn, Shanta Nag, Pietro V De Camilli, Kallol Gupta, Thomas J Melia
As the autophagosome forms, its membrane surface area expands rapidly, while its volume is kept low. Protein-mediated transfer of lipids from another organelle to the autophagosome likely drives this expansion, but as these lipids are only introduced into the cytoplasmic-facing leaflet of the organelle, full membrane growth also requires lipid scramblase activity. ATG9 harbors scramblase activity and is essential to autophagosome formation; however, whether ATG9 is integrated into mammalian autophagosomes remains unclear...
July 3, 2023: Journal of Cell Biology
#35
REVIEW
Elham Sajjadi, Elena Guerini-Rocco, Elisa De Camilli, Oriana Pala, Giovanni Mazzarol, Konstantinos Venetis, Mariia Ivanova, Nicola Fusco
The introduction of novel anti-HER2 antibody-drug conjugates (ADC) for the treatment of HER2-low breast cancers has transformed the traditional dichotomy of HER2 status to an expanded spectrum. However, the identification of HER2-low (i.e., immunohistochemistry (IHC) score 1 + or IHC score 2+, without gene amplification) tumors is challenged by methodological and analytical variables that might influence the sensitivity and reproducibility of HER2 testing. To open all possible therapeutic opportunities for HER2-low breast cancer patients the implementation of more accurate and reproducible testing strategies is mandatory...
2023: Frontiers in Molecular Biosciences
#36
REVIEW
Matheus Correia Casotti, Débora Dummer Meira, Lyvia Neves Rebello Alves, Barbara Gomes de Oliveira Bessa, Camilly Victória Campanharo, Creuza Rachel Vicente, Carla Carvalho Aguiar, Daniel de Almeida Duque, Débora Gonçalves Barbosa, Eldamária de Vargas Wolfgramm Dos Santos, Fernanda Mariano Garcia, Flávia de Paula, Gabriel Mendonça Santana, Isabele Pagani Pavan, Luana Santos Louro, Raquel Furlani Rocon Braga, Raquel Silva Dos Reis Trabach, Thomas Santos Louro, Elizeu Fagundes de Carvalho, Iúri Drumond Louro
Translational Bioinformatics (TBI) is defined as the union of translational medicine and bioinformatics. It emerges as a major advance in science and technology by covering everything, from the most basic database discoveries, to the development of algorithms for molecular and cellular analysis, as well as their clinical applications. This technology makes it possible to access the knowledge of scientific evidence and apply it to clinical practice. This manuscript aims to highlight the role of TBI in the study of complex diseases, as well as its application to the understanding and treatment of cancer...
February 6, 2023: Genes
#37
JOURNAL ARTICLE
Xin Yi Ng, Yumei Wu, Youneng Lin, Sidra Mohamed Yaqoob, Lois E Greene, Pietro De Camilli, Mian Cao
Parkinson's disease (PD) is a neurodegenerative disorder characterized by defective dopaminergic (DAergic) input to the striatum. Mutations in two genes encoding synaptically enriched clathrin-uncoating factors, synaptojanin 1 (SJ1) and auxilin, have been implicated in atypical Parkinsonism. SJ1 knock-in (SJ1-KIRQ ) mice carrying a disease-linked mutation display neurological manifestations reminiscent of Parkinsonism. Here we report that auxilin knockout (Aux-KO) mice display dystrophic changes of a subset of nigrostriatal DAergic terminals similar to those of SJ1-KIRQ mice...
February 15, 2023: NPJ Parkinson's Disease
#38
Junhyun Park, Kenneth G Miller, Pietro De Camilli, Shaul Yogev
Axonal transport is key to neuronal function. Efficient transport requires specific motor-cargo association in the soma, yet the mechanisms regulating this early step remain poorly understood. We found that EBP-1, the C. elegans ortholog of the canonical microtubule end binding protein EB1, promotes the specific association between kinesin-3/KIF1A/UNC-104 and Dense Core Vesicles (DCVs) prior to their axonal delivery. Using single-neuron, in vivo labelling of endogenous cargo and EBs, we observed reduced axonal abundance and reduced secretion of DCV cargo, but not other KIF1A/UNC-104 cargo, in ebp-1 mutants...
January 12, 2023: bioRxiv
#39
JOURNAL ARTICLE
Daehun Park, Yumei Wu, Xinbo Wang, Swetha Gowrishankar, Aaron Baublis, Pietro De Camilli
Ectopic expression in fibroblasts of synapsin 1 and synaptophysin is sufficient to generate condensates of vesicles highly reminiscent of synaptic vesicle (SV) clusters and with liquid-like properties. Here we show that unlike synaptophysin, other major integral SV membrane proteins fail to form condensates with synapsin, but co-assemble into the clusters formed by synaptophysin and synapsin in this ectopic expression system. Another vesicle membrane protein, ATG9A, undergoes activity-dependent exo-endocytosis at synapses, raising questions about the relation of ATG9A traffic to the traffic of SVs...
January 28, 2023: Nature Communications
#40
JOURNAL ARTICLE
Mariana Souza, Camilly P Pires de Melo, Letícia Villafranca Faro, Luciane Fragel-Madeira, Viveca Giongo, Paula Alvarez Abreu, Fernanda da Costa Santos Boechat, David de Oliveira Silva, Nathalia Motta de Carvalho Tolentino, Claudio Cesar Cirne-Santos, Caroline de Souza Barros, Helena C Castro, Marcos Costa de Souza, Maria Cecília B V de Souza, Izabel C N P Paixão
BACKGROUND: Since the emergence of HSV resistant strains, new antiviral agents have emerged and still are urgently needed, especially those with alternative targets. OBJECTIVE: In this work, we evaluated new quinolone derivatives as anti-HSV. METHODS: For this study, cells were infected and treated with different components to evaluate the profile of HSV replication in vitro. In addition, studies were performed to determine the pharmacokinetic toxicity and profile of the compound...
December 20, 2022: Current Topics in Medicinal Chemistry
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