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https://www.readbyqxmd.com/read/28194546/a-multisite-benchmarking-trial-of-capnometry-guided-respiratory-intervention-for-panic-disorder-in-naturalistic-treatment-settings
#1
David F Tolin, Patrick B McGrath, Lisa R Hale, Daniel N Weiner, Ralitza Gueorguieva
Panic disorder (PD) is associated with hyperventilation. The efficacy of a brief respiratory feedback program for PD has been established. The aim of the present study was to expand these results by testing a similar program with more clinically representative patients and settings. Sixty-nine adults with PD received 4 weeks of Capnometry Guided Respiratory Intervention (CGRI) using Freespira, which provides feedback of end-tidal CO2 (PETCO2) and respiration rate (RR), in four non-academic clinical settings...
March 2017: Applied Psychophysiology and Biofeedback
https://www.readbyqxmd.com/read/28109869/outcomes-infectiousness-and-transmission-dynamics-of-patients-with-extensively-drug-resistant-tuberculosis-and-home-discharged-patients-with-programmatically-incurable-tuberculosis-a-prospective-cohort-study
#2
Keertan Dheda, Jason D Limberis, Elize Pietersen, Jody Phelan, Aliasgar Esmail, Maia Lesosky, Kevin P Fennelly, Julian Te Riele, Barbara Mastrapa, Elizabeth M Streicher, Tania Dolby, Abdallah M Abdallah, Fathia Ben-Rached, John Simpson, Liezel Smith, Tawanda Gumbo, Paul van Helden, Frederick A Sirgel, Ruth McNerney, Grant Theron, Arnab Pain, Taane G Clark, Robin M Warren
BACKGROUND: The emergence of programmatically incurable tuberculosis threatens to destabilise control efforts. The aim of this study was to collect prospective patient-level data to inform treatment and containment strategies. METHODS: In a prospective cohort study, 273 South African patients with extensively drug-resistant tuberculosis, or resistance beyond extensively drug-resistant tuberculosis, were followed up over a period of 6 years. Transmission dynamics, infectiousness, and drug susceptibility were analysed in a subset of patients from the Western Cape using whole-genome sequencing (WGS; n=149), a cough aerosol sampling system (CASS; n=26), and phenotypic testing for 18 drugs (n=179)...
January 18, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28086991/does-waterfall-aerosol-influence-mucosal-immunity-and-chronic-stress-a-randomized-controlled-clinical-trial
#3
Carina Grafetstätter, Martin Gaisberger, Johanna Prossegger, Markus Ritter, Predrag Kolarž, Christina Pichler, Josef Thalhamer, Arnulf Hartl
BACKGROUND: The specific microclimate of alpine waterfalls with high levels of ionized water aerosols has been suggested to trigger beneficial immunological and psychological effects. In the present three-armed randomized controlled clinical study, we focused on effects on (i) immunological reagibility, on (ii) physiological stress responses, and on (iii) stress-related psychological parameters. METHODS: People with moderate to high stress levels (n = 65) spent an active sojourn with daily hiking tours in the National Park Hohe Tauern (Großkirchheim, Austria)...
January 13, 2017: Journal of Physiological Anthropology
https://www.readbyqxmd.com/read/27993527/use-of-electric-field-sensors-for-recording-respiration-heart-rate-and-stereotyped-motor-behaviors-in-the-rodent-home-cage
#4
Donald J Noble, Camden J MacDowell, Michael L McKinnon, Tamra I Neblett, William N Goolsby, Shawn Hochman
BACKGROUND: Numerous environmental and genetic factors can contribute significantly to behavioral and cardiorespiratory variability observed experimentally. Affordable technologies that allow for noninvasive home cage capture of physio-behavioral variables should enhance understanding of inter-animal variability including after experimental interventions. NEW METHOD: We assessed whether EPIC electric field sensors (Plessey Semiconductors) embedded within or attached externally to a rodent's home cage could accurately record respiration, heart rate, and motor behaviors...
February 1, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/27936351/metal-exposures-at-three-u-s-electronic-scrap-recycling-facilities
#5
Diana Ceballos, Catherine Beaucham, Elena Page
Many metals found in electronic scrap are known to cause serious health effects, including but not limited to cancer and respiratory, neurologic, renal, and reproductive damage. The National Institute for Occupational Safety and Health/Centers for Disease Control and Prevention performed three health hazard evaluations at electronic scrap recycling facilities in the U.S. to characterize employee exposure to metals and recommend control strategies to reduce these exposures. We performed air, surface, and biological monitoring for metals...
December 9, 2016: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/27797801/weston-hurst-syndrome-a-rare-fulminant-form-of-acute-disseminated-encephalomyelitis-adem
#6
Sumaira Nabi, Mazhar Badshah, Shahzad Ahmed, Ali Zohair Nomani
A 25-year-old Pakistani woman presented to the emergency department with a 2-day history of rapidly progressive tetraplegia followed by sudden loss of consciousness. This was preceded by an upper respiratory tract infection. On examination, she was deeply comatose with a GCS of 3/15 and intact brainstem reflexes. She was in respiratory distress, and an endotracheal tube had been passed. She had flaccid quadriplegia with depressed deep tendon reflexes and upgoing plantar response. Her MRI brain with contrast showed extensive brainstem involvement with haemorrhagic foci along with signal changes in the corpus callosum...
October 19, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27708585/comparative-analysis-of-the-equivital-eq02-lifemonitor-with-holter-ambulatory-ecg-device-for-continuous-measurement-of-ecg-heart-rate-and-heart-rate-variability-a-validation-study-for-precision-and-accuracy
#7
Abimbola A Akintola, Vera van de Pol, Daniel Bimmel, Arie C Maan, Diana van Heemst
Background: The Equivital (EQ02) is a multi-parameter telemetric device offering both real-time and/or retrospective, synchronized monitoring of ECG, HR, and HRV, respiration, activity, and temperature. Unlike the Holter, which is the gold standard for continuous ECG measurement, EQO2 continuously monitors ECG via electrodes interwoven in the textile of a wearable belt. Objective: To compare EQ02 with the Holter for continuous home measurement of ECG, heart rate (HR), and heart rate variability (HRV). Methods: Eighteen healthy participants wore, simultaneously for 24 h, the Holter and EQ02 monitors...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27626633/unconstrained-sleep-stage-estimation-based-on-respiratory-dynamics-and-body-movement
#8
Su H Hwang, Yu J Lee, Do U Jeong, Kwang S Park
OBJECTIVES: The aim of this study is to establish a sleep monitoring method that can classify sleep into four stages in an unconstrained manner using a polyvinylidene fluoride (PVDF) sensor for continuous and accurate estimation of sleep stages. METHODS: The study participants consisted of 12 normal subjects and 13 obstructive sleep apnea (OSA) patients. The physiological signals of the subjects were unconstrainedly measured using the PVDF sensor during polysomnography...
December 7, 2016: Methods of Information in Medicine
https://www.readbyqxmd.com/read/27598922/-weannet-the-network-of-weaning-units-of-the-dgp-deutsche-gesellschaft-f%C3%A3-r-pneumologie-und-beatmungsmedizin-results-to-epidemiology-an-outcome-in-patients-with-prolonged-weaning
#9
(no author information available yet)
BACKGROUND: In 40 % of all ventilated patients weaning is problematic. Prolonged weaning is associated with an increased mortality. METHODS: For the first time, data on epidemiology and outcomes of 6899 patients with prolonged weaning from the WeanNet register are published in this study. RESULTS: Patients with prolonged weaning suffer from profound comorbidities (median 5 relevant comorbidities). The majority of patients (62.2 %) were successfully weaned from the ventilator and dischared from the weaning unit without invasive ventialtion after a median of 33 days...
September 2016: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27440136/dust-library-of-plasmonically-enhanced-infrared-spectra-of-individual-respirable-particles
#10
Antriksh Luthra, Aruna Ravi, Sirui Li, Steven V Nystrom, Zechariah Thompson, James V Coe
This work characterizes collections of infrared spectra of individual dust particles of ∼4 µm size that were obtained from three very different environments: our lab air, a home air filter, and the 11 September 2001 World Trade Center event. Particle collection was done either directly from the air or by placing dust powder from various samples directly on the plasmonic mesh with 5 µm square holes as air is pumped through the mesh. This arrangement enables the recording of "scatter-free" infrared absorption spectra of individual particles of size comparable to the probing wavelengths whose vibrational signatures are otherwise dominated by scattering and dispersive line shape distortions...
September 2016: Applied Spectroscopy
https://www.readbyqxmd.com/read/27401086/creatine-transporter-deficiency-leads-to-increased-whole-body-and-cellular-metabolism
#11
Marla K Perna, Amanda N Kokenge, Keila N Miles, Kenea C Udobi, Joseph F Clark, Gail J Pyne-Geithman, Zaza Khuchua, Matthew R Skelton
Creatine (Cr) is a guanidino compound required for rapid replenishment of ATP in cells with a high-energy demand. In humans, mutations in the Cr transporter (CRT;SLC6A8) prevent Cr entry into tissue and result in a significant intellectual impairment, epilepsy, and aphasia. The lack of Cr on both the whole body and cellular metabolism was evaluated in Crt knockout (Crt (-/y) ) mice, a high-fidelity model of human CRT deficiency. Crt (-/y) mice have reduced body mass and, however, show a twofold increase in body fat...
August 2016: Amino Acids
https://www.readbyqxmd.com/read/27397661/effectiveness-of-oral-appliances-in-obstructive-sleep-apnea-with-respiratory-arousals
#12
Pia Nerfeldt, Danielle Friberg
STUDY OBJECTIVES: To compare adherence and treatment effects with an oral appliance (OA) in patients with different types of obstructive sleep apnea (OSA): those with mainly respiratory arousals ("arousers"), and those with oxygen desaturations ("desaturaters") at polysomnography (PSG). METHODS: A prospective intervention study on 72 "tired snorers" with "normal" home sleep study (HSS), but later diagnosed as OSA with PSG, who accepted OA treatment. They were offered evaluation with a follow-up PSG and questionnaires, including the Epworth Sleepiness Scale (ESS), general health (GH), satisfaction, and side effects...
August 15, 2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/27327257/nucleus-accumbens-deep-brain-stimulation-efficacy-in-acth-pretreated-rats-alterations-in-mitochondrial-function-relate-to-antidepressant-like-effects
#13
Y Kim, S McGee, J K Czeczor, A J Walker, R P Kale, A Z Kouzani, K Walder, M Berk, S J Tye
Mitochondrial dysfunction has a critical role in the pathophysiology of mood disorders and treatment response. To investigate this, we established an animal model exhibiting a state of antidepressant treatment resistance in male Wistar rats using 21 days of adrenocorticotropic hormone (ACTH) administration (100 μg per day). First, the effect of ACTH treatment on the efficacy of imipramine (10 mg kg(-1)) was investigated alongside its effect on the prefrontal cortex (PFC) mitochondrial function. Second, we examined the mood-regulatory actions of chronic (7 day) high-frequency nucleus accumbens (NAc) deep-brain stimulation (DBS; 130 Hz, 100 μA, 90 μS) and concomitant PFC mitochondrial function...
2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27067482/sdf-1-cxcl12-modulates-mitochondrial-respiration-of-immature-blood-cells-in-a-bi-phasic-manner
#14
Steven Messina-Graham, Hal Broxmeyer
SDF-1/CXCL12 is a potent chemokine required for the homing and engraftment of hematopoietic stem and progenitor cells. Previous data from our group has shown that in an SDF-1/CXCL12 transgenic mouse model, lineage(-) Sca-1(+) c-Kit(+) (LSK) bone marrow cells have reduced mitochondrial membrane potential versus wild-type. These results suggested that SDF-1/CXCL12 may function to keep mitochondrial respiration low in immature blood cells in the bone marrow. Low mitochondrial metabolism helps to maintain low levels of reactive oxygen species (ROS), which can influence differentiation...
May 2016: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/26967045/measuring-cardiac-autonomic-nervous-system-ans-activity-in-toddlers-resting-and-developmental-challenges
#15
Nicole R Bush, Zoe K Caron, Katherine S Blackburn, Abbey Alkon
The autonomic nervous system (ANS) consists of two branches, the parasympathetic and sympathetic nervous systems, and controls the function of internal organs (e.g., heart rate, respiration, digestion) and responds to everyday and adverse experiences (1). ANS measures in children have been found to be related to behavior problems, emotion regulation, and health (2-7). Therefore, understanding the factors that affect ANS development during early childhood is important. Both branches of the ANS affect young children's cardiovascular responses to stimuli and have been measured noninvasively, via external monitoring equipment, using valid and reliable measures of physiological change (8-11)...
February 25, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/26847975/sleep-quality-changes-in-chronically-depressed-patients-treated-with-mindfulness-based-cognitive-therapy-or-the-cognitive-behavioral-analysis-system-of-psychotherapy-a-pilot-study
#16
RANDOMIZED CONTROLLED TRIAL
Preetam J Schramm, Ingo Zobel, Kathrin Mönch, Elisabeth Schramm, Johannes Michalak
OBJECTIVE: To capture any sleep quality changes associated with group psychotherapy. PATIENTS/METHODS: Physician-referred, chronically depressed patients (n = 25) were randomized to either eight group sessions of Mindfulness-based Cognitive Therapy (MBCT, n = 9) plus Treatment As Usual (TAU), or the Cognitive Behavioral Analysis System of Psychotherapy (CBASP, n = 8) plus TAU, or to TAU only (control group, n = 8). Participants recorded their sleep at home...
January 2016: Sleep Medicine
https://www.readbyqxmd.com/read/26797725/mechanistic-pathways-of-mindfulness-meditation-in-combat-veterans-with-posttraumatic-stress-disorder
#17
RANDOMIZED CONTROLLED TRIAL
Helané Wahbeh, Elena Goodrich, Elizabeth Goy, Barry S Oken
OBJECTIVE: This study's objective was to evaluate the effect of two common components of meditation (mindfulness and slow breathing) on potential mechanistic pathways. METHODS: A total of 102 combat veterans with posttraumatic stress disorder (PTSD) were randomized to (a) the body scan mindfulness meditation (MM), (b) slow breathing (SB) with a biofeedback device, (c) mindful awareness of the breath with an intention to slow the breath (MM+SB), or (d) sitting quietly (SQ)...
April 2016: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/26775187/inhalation-a-significant-exposure-route-for-chlorinated-organophosphate-flame-retardants
#18
Erika D Schreder, Nancy Uding, Mark J La Guardia
Chlorinated organophosphate flame retardants (ClOPFRs) are widely used as additive flame retardants in consumer products including furniture, children's products, building materials, and textiles. Tests of indoor media in homes, offices, and other environments have shown these compounds are released from products and have become ubiquitous indoor pollutants. In house dust samples from Washington State, U.S.A., ClOPFRs were the flame retardants detected in the highest concentrations. Two ClOPFRs, tris(1,3-dichloro-2-propyl)phosphate (TDCPP or TDCIPP) and tris(2-chloroethyl)phosphate (TCEP), have been designated as carcinogens, and there is growing concern about the toxicity of the homologue tris(1-chloro-2-propyl)phosphate (TCPP or TCIPP)...
May 2016: Chemosphere
https://www.readbyqxmd.com/read/26710646/-responses-of-soil-microbial-carbolic-metabolism-characteristics-to-home-field-advantage-of-leaf-litter-decomposition-in-liaoheyuan-nature-reserve-of-northern-hebei-province-china
#19
Tian-yu Li, Feng-feng Kang, Hai-rong Han, Jing Gao, Xiao-shuai Song, Shu Yu
Using litter bag method, we studied the responses of soil microbial biomass carbon (MBC), microbial respiration (MR) and microbial metabolic quotient (qCO2) in 0-5 cm, 5-10 cm and 10-20 cm soil layers to home-field advantage of Betula platyphlla and Quercus mongolica leaf litter decomposition in Liaoheyuan Nature Reserve, northern Hebei Province. The results showed that the contents of MBC in Betula platyphila and Quercus mongolica leaf litter treatments in home environment (Bh and Qh treatments) were significant higher than that in B...
July 2015: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/26686520/the-18th-collegium-ramazzini-statement-the-global-health-dimensions-of-asbestos-and-asbestos-related-diseases
#20
(no author information available yet)
The Collegium Ramazzini reaffirms its long-standing position that responsible public health action is to ban all extraction and use of asbestos, including chrysotile. This current statement updates the Collegium's earlier statements with a focus on global health dimensions of asbestos and asbestos-related diseases (ARD). The ARD epidemic will likely not peak for at least a decade in most industrialized countries and for several decades in industrializing countries. Asbestos and ARD will continue to present challenges in the arena of occupational medicine and public health, as well as in clinical research and practice, and have thus emerged as a global health issue...
January 2016: Scandinavian Journal of Work, Environment & Health
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