Chunjia Jin, Shengru Wu, Ziqi Liang, Jun Zhang, Xinjian Lei, Hanxun Bai, Gaofeng Liang, Xiaodong Su, Xiaodong Chen, Peiyue Wang, Yue Wang, Leluo Guan, Junhu Yao
BACKGROUND: Although rumen development is crucial, hindgut undertakes a significant role in young ruminants' physiological development. High-starch diet is usually used to accelerate rumen development for young ruminants, but always leading to the enteral starch overload and hindgut dysbiosis. However, the mechanism behind remains unclear. The combination of colonic transcriptome, colonic luminal metabolome, and metagenome together with histological analysis was conducted using a goat model, with the aim to identify the potential molecular mechanisms behind the disrupted hindgut homeostasis by overload starch in young ruminants...
February 24, 2024: Microbiome