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https://www.readbyqxmd.com/read/28003109/bilateral-hand-transplantation-supporting-the-patient-s-choice
#1
M Dumont, L Sann, A Gazarian
Bilateral hand transplantation, as a fairly new reconstructive option for amputees, raises major ethical questions. This article, which is based on the reflections arising from the rich experience of Lyon's team in this field, addresses the topic of supporting the patient in his choice for or against this procedure. How should autonomy be understood in this particular setting? The developing field of composite tissue allotransplantation needs to establish a common thinking on this subject. The article emphasises that, even if it is their right to decide, patients have to be carefully supported to help them make the most consolidated choice possible in this challenging procedure...
November 24, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/27989341/juvenile-particulate-osteochondral-allograft-for-treatment-of-osteochondral-lesions-of-the-talus-detection-of-altered-repair-tissue-biochemical-composition-using-7-tesla-mri-and-t2-mapping
#2
Shaleen Vira, Austin J Ramme, Cary Chapman, Ding Xia, Ravinder R Regatte, Gregory Chang
During the previous 2 decades, numerous surgical procedures have become available to treat osteochondral lesions of the talus. The objective of the present study was to use 7 Tesla (7T) magnetic resonance imaging (MRI) to quantify and compare T2 values (a marker of collagen architecture) of native tibiotalar cartilage and cartilage repair tissue in patients treated with a juvenile particulate allograft for osteochondral lesions of the talus. The institutional review board approved the present study, and all subjects provided written informed consent...
January 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/27931590/cytotoxic-t-lymphocyte-associated-protein-4-acts-on-local-draining-lymph-nodes-in-the-allogeneic-abdominal-skin-flap-of-a-rat-model-to-extend-its-survival
#3
G Ma, J Pei, Y Li, Y Han, D Liu
BACKGROUND: Early acute allograft rejection is the result of immune cells mainly composed of thymocyte (T) cells, which are activated, mature, and differentiate in lymphoid tissue. METHODS: Cytotoxic T lymphocyte-associated protein 4 immunoglobulin (CTLA4-Ig) competitively suppresses the cluster of differentiation 28/CTLA4-B7 costimulatory signaling pathway and alters the ratio of T helper 1 to T helper 2, leading to the inhibition of T cell activation. RESULTS: We used lentivirus-packed CTLA4-Ig to infect the local draining lymph nodes of the allograft skin flap in a rat model, which effectively extended the survival of the allograft...
December 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27873528/transplantation-of-vascularized-composite-allografts-review-of-current-knowledge
#4
M Molitor
Transplantation in reconstructive surgery has been performed for more than 20 years, although the official beginning of these procedures is considered the first successful transplantation of the hand in 1998. The original name "Composite Tissue Transplantation" has been used less frequently; more common is the term "Vascularized Composite Allotransplant", which better describes the basis of the procedure. There have been so far approximately 180 transplantations performed, the exact number is difficult to find...
2016: Acta Chirurgiae Plasticae
https://www.readbyqxmd.com/read/27752256/understanding-immune-cells-in-tertiary-lymphoid-organ-development-it-is-all-starting-to-come-together
#5
REVIEW
Gareth W Jones, David G Hill, Simon A Jones
Tertiary lymphoid organs (TLOs) are frequently observed in tissues affected by non-resolving inflammation as a result of infection, autoimmunity, cancer, and allograft rejection. These highly ordered structures resemble the cellular composition of lymphoid follicles typically associated with the spleen and lymph node compartments. Although TLOs within tissues show varying degrees of organization, they frequently display evidence of segregated T and B cell zones, follicular dendritic cell networks, a supporting stromal reticulum, and high endothelial venules...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27740465/perioperative-management-of-a-bilateral-forearm-allograft
#6
M Clerc, J Prothet, T Rimmelé
Composite tissue allotransplantation (CTA) is a complex procedure requiring a multidisciplinary collaboration between surgeons, anesthetists, and transplantation specialists. We will describe the perioperative management of a bilateral forearm allograft performed at our facility. A 40-year-old man who lost both forearms was registered on the transplant waiting list; a suitable graft was available 11months later. Anesthesia required planning for vascular access, hemodynamic monitoring, fluid therapy management and prevention of deep vein thrombosis...
June 2016: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/27722242/periosteum-tissue-engineering-a-review
#7
Nanying Li, Juqing Song, Guanglin Zhu, Xiaoyu Li, Lei Liu, Xuetao Shi, Yingjun Wang
As always, the clinical therapy of critical size bone defects caused by trauma, tumor removal surgery or congenital malformation is facing great challenges. Currently, various approaches including autograft, allograft and cell-biomaterial composite based tissue-engineering strategies have been implemented to reconstruct injured bone. However, due to damage during the transplantation processes or design negligence of the bionic scaffolds, these methods expose vulnerabilities without the assistance of periosteum, a bilayer membrane on the outer surface of the bone...
October 18, 2016: Biomaterials Science
https://www.readbyqxmd.com/read/27679752/plastic-surgery-challenges-in-war-wounded-ii-regenerative-medicine
#8
REVIEW
Ian L Valerio, Jennifer M Sabino, Christopher L Dearth
Background: A large volume of service members have sustained complex injuries during Operations Iraqi Freedom (OIF) and Enduring Freedom (OEF). These injuries are complicated by contamination with particulate and foreign materials, have high rates of bacterial and/or fungal infections, are often composite-type defects with massive soft tissue wounds, and usually have multisystem involvement. While traditional treatment modalities remain a mainstay for optimal wound care, traditional reconstruction approaches alone may be inadequate to fully address the scope and magnitude of such massive complex wounds...
September 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/27556604/effect-of-cold-preservation-on-chronic-rejection-in-a-rat-hindlimb-transplantation-model
#9
Jorge Bonastre, Luis Landín, Pedro Bolado, César Casado-Sánchez, Eduardo López-Collazo, Jesús Díez
BACKGROUND: Previous studies on solid organ transplantation have shown that cold ischemia contributes to the development of chronic allograft vasculopathy. The authors evaluated the effect of cold ischemia on the development of chronic rejection in vascularized composite allotransplantation. METHODS: Thirty rat hindlimbs were transplanted and divided into two experimental groups: immediate transplantation and transplantation after 7 hours of cold ischemia. The animals received daily low-dose immunosuppression with cyclosporine A for 2 months...
September 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27546723/modular-megaprosthesis-reconstruction-for-oncological-and-non-oncological-resection-of-the-elbow-joint
#10
Rodolfo Capanna, Francesco Muratori, Francesco R Campo, Antonio D'Arienzo, Filippo Frenos, Giovanni Beltrami, Guido Scoccianti, Pierluigi Cuomo, Andrea Piccioli, Daniel A Müller
BACKGROUND: Reconstruction of large bone defects around the elbow joint is surgically demanding due to sparse soft tissue coverage, complex biomechanics and the close proximity to neurovascular structures. Modular megaprostheses are established reconstruction tools for the elbow, but only small case series have been reported in the literature. METHODS: Thirty-six patients who underwent reconstruction of the elbow joint with a modular megaprosthesis were reviewed retrospectively...
October 2016: Injury
https://www.readbyqxmd.com/read/27543201/increasing-donation-opportunities-for-vascularized-composite-allografts-an-analysis-of-worldwide-donor-registries-and-procurement-organization-web-content-volar-study
#11
Katrina A Bramstedt
There are 40 vascularized composite allotransplant programs across 5 continents served by 31 organ procurement organizations (or equivalent). The organizations' websites inform about organ and tissue donation. This research explored worldwide educational efforts on vascularized composite allograft (VCAG) donation via their corporate websites as well as options within donor registries and donor card systems to indicate a VCAG donation preference. Of these, 13 (41.9%) of 31 had VCAG content and 7 (22.6%) of 31 offered a mechanism for individuals to voice a preference about VCAG donation through an opt in donor registry or card or an opt out registry...
August 19, 2016: Progress in Transplantation
https://www.readbyqxmd.com/read/27538107/characterization-of-a-cryopreserved-split-thickness-human-skin-allograft-theraskin
#12
Adam Landsman, Eran Rosines, Amanda Houck, Angela Murchison, Alyce Jones, Xiaofei Qin, Silvia Chen, Arnold R Landsman
OBJECTIVE: The purpose of this study was to examine the characteristics of a cryopreserved split-thickness skin allograft produced from donated human skin and compare it with fresh, unprocessed human split-thickness skin. BACKGROUND: Cutaneous wound healing is a complex and organized process, where the body re-establishes the integrity of the injured tissue. However, chronic wounds, such as diabetic or venous stasis ulcers, are difficult to manage and often require advanced biologics to facilitate healing...
September 2016: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/27517069/evaluation-of-clinical-results-and-complications-of-structural-allograft-reconstruction-after-bone-tumor-surgery
#13
Mohammad Gharedaghi, Mohammad Taghi Peivandi, Mehdi Mazloomi, Hasan Rahimi Shoorin, Mohammad Hasani, Parham Seyf, Fatemeh Khazaee
BACKGROUND: Massive bone allograft is an option in cases of limb preservation and reconstruction after massive benign and malignant bone tumor resection. The purpose of this study was to analyze the outcome of these procedures at Imam Reza Hospital, Mashhad University of Medical Sciences. METHODS: In this study, 113 cases have been presented. Eleven cases were excluded (patients has a traumatic defect or they passed away before the completion of the study's two-year follow up period)...
June 2016: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/27515453/effect-of-anatomic-site-and-irradiation-on-the-rates-of-revision-and-infection-of-allograft-prosthesis-composites-after-resection-of-a-primary-bone-tumor-a-meta-analysis
#14
Jean-Charles Aurégan, Raphaël Pietton, Thierry Bégué, Philippe Anract, David Biau
INTRODUCTION: Allograft-prosthesis composite reconstruction after resection of a primary bone tumor may have theoretical advantages, such as restoration of bone stock and soft tissue attachments. However, the reported results of APC of different anatomical sites differ widely. We conducted a meta-analysis to estimate the revision and infection rates associated with allograft-prosthesis composite (APC) reconstructions after resection of a primary bone tumor. We looked for variables, such as anatomic sites and irradiation of the allograft, associated with these outcomes...
October 2016: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/27474556/a-review-of-chitosan-and-its-derivatives-in-bone-tissue-engineering
#15
REVIEW
R LogithKumar, A KeshavNarayan, S Dhivya, A Chawla, S Saravanan, N Selvamurugan
Critical-sized bone defects treated with biomaterials offer an efficient alternative to traditional methods involving surgical reconstruction, allografts, and metal implants. Chitosan, a natural biopolymer is widely studied for bone regeneration applications owing to its tunable chemical and biological properties. However, the potential of chitosan to repair bone defects is limited due to its water insolubility, faster in vivo depolymerization, hemo-incompatibility, and weak antimicrobial property. Functionalization of chitosan structure through various chemical modifications provides a solution to these limitations...
October 20, 2016: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27453269/combined-pcr-and-q-rt-pcr-technique-for-detecting-chimerism-in-a-non-human-primate-vascularized-osteomyocutaneous-allografts-model
#16
J Jiang, J Wang, F Zhong, G Chen, Y Li, X X Zheng
Face transplantation and other composite tissue transplantation (CTA) are permissive to transplantation tolerance. The real reason, that composite tissue containing bone achieves transplantation immune tolerance more easily than the composite tissue without the bone is not clear. The chimerism may be the main mechanism in the progress of inducing the transplantation tolerance by CTA. We currently have established a non-human Primate Vascularized Osteomyocutaneous Allografts Model. To test the chimerism which comes from donor after the transplantation, we developed a method which combined reverse transcription polymerase chain reaction (RT-PCR) and real-time quantitative PCR (qRT-PCR) technique using primers specific for Macaca fascicularis sex determination region on the Y chromosome (SRY) gene...
June 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/27446265/use-of-a-biological-reactor-and-platelet-rich-plasma-for-the-construction-of-tissue-engineered-bone-to-repair-articular-cartilage-defects
#17
Huibo Li, Shui Sun, Haili Liu, Hua Chen, Xin Rong, Jigang Lou, Yunbei Yang, Yi Yang, Hao Liu
Articular cartilage defects are a major clinical burden worldwide. Current methods to repair bone defects include bone autografts, allografts and external fixation. In recent years, the repair of bone defects by tissue engineering has emerged as a promising approach. The present study aimed to assess a novel method using a biological reactor with platelet-rich plasma to construct tissue-engineered bone. Beagle bone marrow mesenchymal stem cells (BMSCs) were isolated and differentiated into osteoblasts and chondroblasts using platelet-rich plasma and tricalcium phosphate scaffolds cultured in a bioreactor for 3 weeks...
August 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27421969/adipose-gene-expression-profile-changes-with-lung-allograft-reperfusion
#18
J M Diamond, S Arcasoy, J A McDonnough, J R Sonett, M Bacchetta, F D'Ovidio, E Cantu, C A Bermudez, A McBurnie, M Rushefski, L H Kalman, M Oyster, C D'Errico, Y Suzuki, J T Giles, A Ferrante, M Lippel, G Singh, D J Lederer, J D Christie
Obesity is a risk factor for primary graft dysfunction (PGD), a form of lung injury resulting from ischemia-reperfusion after lung transplantation, but the impact of ischemia-reperfusion on adipose tissue is unknown. We evaluated differential gene expression in thoracic visceral adipose tissue (VAT) before and after lung reperfusion. Total RNA was isolated from thoracic VAT sampled from six subjects enrolled in the Lung Transplant Body Composition study before and after allograft reperfusion and quantified using the Human Gene 2...
January 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/27267575/3d-printed-scaffolds-with-bactericidal-activity-aimed-for-bone-tissue-regeneration
#19
Tiago R Correia, Daniela R Figueira, Kevin D de Sá, Sónia P Miguel, Ricardo G Fradique, António G Mendonça, Ilídio J Correia
Nowadays, the incidence of bone disorders has steeply ascended and it is expected to double in the next decade, especially due to the ageing of the worldwide population. Bone defects and fractures lead to reduced patient's quality of life. Autografts, allografts and xenografts have been used to overcome different types of bone injuries, although limited availability, immune rejection or implant failure demand the development of new bone replacements. Moreover, the bacterial colonization of bone substitutes is the main cause of implant rejection...
December 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27248293/airway-microbiota-determines-innate-cell-inflammatory-or-tissue-remodeling-profiles-in-lung-transplantation
#20
Eric Bernasconi, Céline Pattaroni, Angela Koutsokera, Christophe Pison, Romain Kessler, Christian Benden, Paola M Soccal, Antoine Magnan, John-David Aubert, Benjamin J Marsland, Laurent P Nicod
RATIONALE: In lung transplant recipients, long-term graft survival relies upon the control of inflammation and tissue remodeling in order to maintain graft functionality and avoid chronic lung allograft dysfunction. Although advances in clinical practice have improved transplant success, the mechanisms by which the balance between inflammation and remodeling is maintained are largely unknown. OBJECTIVES: To assess whether host-microbe interactions in the transplanted lung determine the immunological tone of the airways, and consequently could impact upon graft survival...
June 1, 2016: American Journal of Respiratory and Critical Care Medicine
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