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https://www.readbyqxmd.com/read/29786775/stormram-4-an-mr-safe-robotic-system-for-breast-biopsy
#1
Vincent Groenhuis, Françoise J Siepel, Jeroen Veltman, Jordy K van Zandwijk, Stefano Stramigioli
Suspicious lesions in the breast that are only visible on magnetic resonance imaging (MRI) need to be biopsied under MR guidance with high accuracy and efficiency for accurate diagnosis. The aim of this study is to present a novel robotic system, the Stormram 4, and to perform preclinical tests in an MRI environment. Excluding racks and needle, its dimensions are 72 × 51 × 40 mm. The Stormram 4 is driven by two linear and two curved pneumatic stepper motors. The linear motor is capable of exerting 63 N of force at a pressure of 0...
May 21, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29781100/factors-associated-with-breast-mri-use-among-women-with-a-family-history-of-breast-cancer
#2
Mary C White, Ashwini Soman, Clarice R Weinberg, Juan L Rodriguez, Susan A Sabatino, Lucy A Peipins, Lisa DeRoo, Hazel B Nichols, M Elizabeth Hodgson, Dale P Sandler
Although annual breast magnetic resonance imaging (MRI) is recommended for women at high risk for breast cancer as an adjunct to screening mammography, breast MRI use remains low. We examined factors associated with breast MRI use in a cohort of women with a family history of breast cancer but no personal cancer history. Study participants came from the Sister Study cohort, a nationwide, prospective study of women with at least 1 sister who had been diagnosed with breast cancer but who themselves had not ever had breast cancer (n = 17 894)...
May 20, 2018: Breast Journal
https://www.readbyqxmd.com/read/29770848/imaging-biomarkers-from-multiparametric-magnetic-resonance-imaging-are-associated-with-survival-outcomes-in-patients-with-brain-metastases-from-breast-cancer
#3
Bang-Bin Chen, Yen-Shen Lu, Chih-Wei Yu, Ching-Hung Lin, Tom Wei-Wu Chen, Shwu-Yuan Wei, Ann-Lii Cheng, Tiffany Ting-Fang Shih
OBJECTIVES: The aim of this study is to investigate the correlation of survival outcomes with imaging biomarkers from multiparametric magnetic resonance imaging (MRI) in patients with brain metastases from breast cancer (BMBC). METHODS: This study was approved by the institutional review board. Twenty-two patients with BMBC who underwent treatment involving bevacizumab on day 1, etoposide on days 2-4, and cisplatin on day 2 in 21-day cycles were prospectively enrolled for a phase II study...
May 16, 2018: European Radiology
https://www.readbyqxmd.com/read/29759590/reasons-for-non-participation-in-supplemental-population-based-mri-breast-screening-for-women-with-extremely-dense-breasts
#4
S V de Lange, M F Bakker, E M Monninkhof, P H M Peeters, P K de Koekkoek-Doll, R M Mann, M J C M Rutten, R H C Bisschops, J Veltman, K M Duvivier, M B I Lobbes, H J de Koning, N Karssemeijer, R M Pijnappel, W B Veldhuis, C H van Gils
AIM: To determine the willingness of women with extremely dense breasts to undergo breast cancer screening with magnetic resonance imaging (MRI) in a research setting, and to examine reasons for women to participate or not. MATERIALS AND METHODS: Between 2011 and 2015, 8,061 women (50-75 years) were invited for supplemental MRI as part of the Dense Tissue and Early Breast Neoplasm Screening (DENSE) trial (ClinicalTrials.gov Identifier: NCT01315015), after a negative screening mammography in the national population-based mammography screening programme...
May 11, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29752327/adherence-to-guidelines-for-breast-surveillance-in-breast-cancer-survivors
#5
Kathryn J Ruddy, Lindsey Sangaralingham, Rachel A Freedman, Sarah Mougalian, Heather Neuman, Caprice Greenberg, Ahmedin Jemal, Narjust Duma, Tufia C Haddad, Valerie Lemaine, Karthik Ghosh, Tina J Hieken, Katie Hunt, Celine Vachon, Cary Gross, Nilay D Shah
Background: Guidelines recommend annual mammography after curative-intent treatment for breast cancer. The goal of this study was to assess contemporary patterns of breast imaging after breast cancer treatment. Methods: Administrative claims data were used to identify privately insured and Medicare Advantage beneficiaries with nonmetastatic breast cancer who had residual breast tissue (not bilateral mastectomy) after breast surgery between January 2005 and May 2015. We calculated the proportion of patients who had a mammogram, MRI, both, or neither during each of 5 subsequent 13-month periods...
May 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29708403/detection-of-unknown-primary-tumor-in-patients-presented-with-brain-metastasis-by-f-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography
#6
Zehra Pınar Koç, Pelin Özcan Kara, Ahmet Dağtekin
AIM:  F-18 fluorodeoxyglucose (FDG) PET/CT has several advantages in diagnosis of cancer of unknown primary with reported incremental diagnostic value. In this study, we evaluated the patients who were presented with multiple brain metastasis and unknown primary tumor. MATERIALS & METHODS: 31 patients (17 males, 14 females; mean: 56.1 ± 14.22 years old) with diagnosis of brain metastasis according to histopathology and/or MRI were included into this retrospective study...
April 30, 2018: CNS Oncology
https://www.readbyqxmd.com/read/29680487/spectrum-of-chronic-complications-related-to-silicone-leakage-and-migration
#7
Alexander J Ryu, Katrina N Glazebrook, Naziya Samreen, Philippe R Bauer, Eunhee S Yi, Jay H Ryu
BACKGROUND: Medical silicone is widely used as implants and free injections but the spectrum of complications related to migration or embolization of silicone remains unclear. METHODS: We retrospectively reviewed 79 patients with silicone migration as confirmed on pathology between January 1, 2001 and December 31, 2016. The presenting clinical and imaging features, diagnostic testing, treatment, and outcome were assessed. RESULTS: Nearly all were women and 43% had a history of breast cancer...
April 19, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29678274/preoperative-mri-evaluation-of-lesion-nipple-distance-in-breast-cancer-patients-thresholds-for-predicting-occult-nipple-areola-complex-involvement
#8
G Mariscotti, M Durando, N Houssami, C M Berzovini, F Esposito, M Fasciano, P P Campanino, D Bosco, R Bussone, A Ala, I Castellano, A Sapino, L Bergamasco, P Fonio, G Gandini
AIM: To identify clinically occult nipple-areola complex (NAC) involvement using preoperative magnetic resonance imaging (MRI), to inform selection of patients eligible for nipple-sparing mastectomy (NSM) or skin-sparing mastectomy (SSM). MATERIAL AND METHODS: This was a retrospective study of 195 patients, who had preoperative breast MRI (February 2011 to January 2017) before undergoing surgical treatments (NSM or SSM) for newly diagnosed breast cancer. Tumour features at MRI (mass or non-mass lesion, diameter, lesion-NAC distance [LND]) and pathology (lesion diameter, histopathological type, receptor status) were recorded, as well as the type of surgery (NSM/SSM) and presence (NAC+) or absence (NAC-) of tumour at intraoperative evaluation of retroareolar tissue...
April 17, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29669584/mri-based-response-patterns-during-neoadjuvant-chemotherapy-can-predict-pathological-complete-response-in-patients-with-breast-cancer
#9
Briete Goorts, Kelly M A Dreuning, Janneke B Houwers, Loes F S Kooreman, Evert-Jan G Boerma, Ritse M Mann, Marc B I Lobbes, Marjolein L Smidt
BACKGROUND: The main purpose was to investigate the correlation between magnetic resonance imaging (MRI)-based response patterns halfway through neoadjuvant chemotherapy and immunotherapy (NAC) and pathological tumor response in patients with breast cancer. Secondary purposes were to compare the predictive value of MRI-based response patterns measured halfway through NAC and after NAC and to measure interobserver variability. METHODS: All consecutive patients treated with NAC for primary invasive breast cancer from 2012 to 2015 and who underwent breast MRI before, halfway through (and after) NAC were included...
April 18, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29658786/imaging-findings-of-mammary-and-systemic-silicone-deposition-secondary-to-breast-implants
#10
Naziya Samreen, Katrina N Glazebrook, Asha Bhatt, Sudhakar K Venkatesh, Brendan P McMenomy, Anupam Chandra, Shuai Ieng, Kalie E Adler, Cynthia H McCollough
In patients with silicone breast implants, implant rupture can occur, which can be intracapsular or extracapsular. Following implant rupture, silicone can travel through the lymphatic system into regional and distant lymph nodes. The purpose of this pictorial essay is to present findings of silicone implant rupture with intramammary and systemic silicone deposition as seen on dual energy CT (DECT), US, mammogram, PET/CT and MRI. We include imaging findings of silicone deposition in the breast in cases of intracapsular and extracapsular rupture...
April 16, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29643136/orbital-metastasis-from-an-occult-breast-carcinoma-t0-n1-m1
#11
Rita Pinto Proença, Júlia Fernandes, Miguel N Burnier, Rui Proença
The authors report a case of an orbital metastasis from an occult breast carcinoma. A 66-year-old woman presented with a growing left orbital tumour. Orbital CT scan was consistent with lymphoma. However, ocular pathology revealed small neoplastic cells showing an 'indian file pattern' suggestive of metastatic carcinoma and immunohistochemistry was positive for CK7, CK CAM5.2 and oestrogen receptor. A systemic evaluation was then performed with mammogram, breast ultrasound and MRI considered normal. An exhaustive systemic evaluation revealed multiple bone lesions, a right axillary lymph node lesion, which presented the same pattern on pathology and immunohistochemistry, with no evidence of a primary tumour...
April 11, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29616369/treatment-response-assessment-with-r-11-cpaq-pet-in-the-mmtv-pymt-mouse-model-of-breast-cancer
#12
T Tegnebratt, L Lu, S Eksborg, A Chireh, P Damberg, S Nikkhou-Aski, T Foukakis, H Rundqvist, S Holmin, R V Kuiper, E Samen
BACKGROUND: The goal of the study was to assess the potential of the vascular endothelial growth factor receptor (VEGFR)-2-targeting carbon-11 labeled (R)-N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methyl-3-piperidinyl)methoxy)-4-quinazolineamine ((R)-[11 C]PAQ) as a positron emission tomography (PET) imaging biomarker for evaluation of the efficacy of anticancer drugs in preclinical models. METHODS: MMTV-PyMT mice were treated with vehicle alone (VEH), murine anti-VEGFA antibody (B20-4...
April 3, 2018: EJNMMI Research
https://www.readbyqxmd.com/read/29613991/imaging-findings-in-papillary-breast-lesions-an-analysis-of-ductal-findings-on-magnetic-resonance-imaging-and-ultrasound
#13
Ozgur Sarica, Murat Dokdok
PURPOSE: This study aims to analyze the imaging features of dilated ducts or ductal extension/relation of masses detected by ultrasound (US) and magnetic resonance imaging (MRI) and to correlate the results obtained through these 2 different imaging methods. Furthermore, the ability of the ductal relation pattern in differentiating benign and malignant lesions was explored. METHODS AND MATERIALS: Magnetic resonance imaging and US findings of 56 patients who had a pathologic diagnosis of papillary lesion were examined...
April 2, 2018: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/29602724/relationship-between-background-parenchymal-enhancement-on-high-risk-screening-mri-and-future-breast-cancer-risk
#14
Lars J Grimm, Ashirbani Saha, Sujata V Ghate, Connie Kim, Mary Scott Soo, Sora C Yoon, Maciej A Mazurowski
RATIONALE AND OBJECTIVES: To determine if background parenchymal enhancement (BPE) on screening breast magnetic resonance imaging (MRI) in high-risk women correlates with future cancer. MATERIALS AND METHODS: All screening breast MRIs (n = 1039) in high-risk women at our institution from August 1, 2004, to July 30, 2013, were identified. Sixty-one patients who subsequently developed breast cancer were matched 1:2 by age and high-risk indication with patients who did not develop breast cancer (n = 122)...
March 27, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29570895/repeatability-reproducibility-and-accuracy-of-quantitative-mri-of-the-breast-in-the-community-radiology-setting
#15
Anna G Sorace, Chengyue Wu, Stephanie L Barnes, Angela M Jarrett, Sarah Avery, Debra Patt, Boone Goodgame, Jeffery J Luci, Hakmook Kang, Richard G Abramson, Thomas E Yankeelov, John Virostko
BACKGROUND: Quantitative diffusion-weighted MRI (DW-MRI) and dynamic contrast-enhanced MRI (DCE-MRI) have the potential to impact patient care by providing noninvasive biological information in breast cancer. PURPOSE/HYPOTHESIS: To quantify the repeatability, reproducibility, and accuracy of apparent diffusion coefficient (ADC) and T1 -mapping of the breast in community radiology practices. STUDY TYPE: Prospective. SUBJECTS/PHANTOM: Ice-water DW-MRI and T1 gel phantoms were used to assess accuracy...
March 23, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29567270/pretreatment-mri-features-associated-with-diagnostic-accuracy-of-post-treatment-mri-after-neoadjuvant-chemotherapy
#16
N L Eun, H M Gweon, E J Son, J H Youk, J-A Kim
AIM: To investigate whether pretreatment magnetic resonance imaging (MRI) features are associated with diagnostic accuracy of post-treatment MRI for predicting pathologic complete response (pCR) after neoadjuvant chemotherapy (NAC) in patients with breast cancer. MATERIALS AND METHODS: From January 2005 and December 2016, 221 consecutive patients (mean age, 50 years; range, 20-81 years) who had undergone NAC, breast MRI before and after NAC, and surgery for invasive breast cancer were enrolled...
March 19, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29556054/appearance-constrained-semi-automatic-segmentation-from-dce-mri-is-reproducible-and-feasible-for-breast-cancer-radiomics-a-feasibility-study
#17
Harini Veeraraghavan, Brittany Z Dashevsky, Natsuko Onishi, Meredith Sadinski, Elizabeth Morris, Joseph O Deasy, Elizabeth J Sutton
We present a segmentation approach that combines GrowCut (GC) with cancer-specific multi-parametric Gaussian Mixture Model (GCGMM) to produce accurate and reproducible segmentations. We evaluated GCGMM using a retrospectively collected 75 invasive ductal carcinoma with ERPR+ HER2- (n = 15), triple negative (TN) (n = 9), and ER-HER2+ (n = 57) cancers with variable presentation (mass and non-mass enhancement) and background parenchymal enhancement (mild and marked). Expert delineated manual contours were used to assess the segmentation performance using Dice coefficient (DSC), mean surface distance (mSD), Hausdorff distance, and volume ratio (VR)...
March 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29550842/tumoricidal-effect-and-pain-relief-after-concurrent-therapy-by-strontium-89-chloride-and-zoledronic-acid-for-bone-metastases
#18
Kenkichi Baba, Hayato Kaida, Chikayuki Hattori, Koichiro Muraki, Tomoko Kugiyama, Hiromasa Fujita, Masatoshi Ishibashi
OBJECTIVE: The purpose of this study was to investigate the palliative and tumoricidal effects of concurrent therapy of strontium-89 chloride (89 SrCl2 ) and zoledronic acid (ZA) for painful bone metastases. SUBJECTS AND METHODS: Fifty-one patients with painful bone metastases prostate cancer (n=17), lung cancer (n=13), breast cancer (n=12), other cancers (n=9) were treated. Bone metastases was confirmed in all patients by technetium-99m hydroxymethylene diphosphonate (99m Tc-HMDP) bone scintigraphy...
March 20, 2018: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29524207/mri-background-parenchymal-enhancement-breast-density-and-serum-hormones-in-postmenopausal-women
#19
Jennifer D Brooks, Janice S Sung, Malcolm C Pike, Irene Orlow, Frank Z Stanczyk, Jonine L Bernstein, Elizabeth A Morris
Background parenchymal enhancement (BPE) is the degree to which normal breast tissue enhances on contrast-enhanced magnetic resonance imaging (MRI). MRI-density is a volumetric measure of breast density that is highly correlated with mammographic density, an established breast cancer risk factor. Endogenous estrogen concentrations are positively associated with postmenopausal breast cancer risk and BPE has been shown to be sensitive to hormonal exposures. The objective of our study was to examine the relationship between BPE and MRI-density and serum hormone concentrations in postmenopausal women...
March 9, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29516372/preoperative-breast-mri-and-mortality-in-older-women-with-breast-cancer
#20
T Onega, W Zhu, J E Weiss, M Goodrich, A N A Tosteson, W DeMartini, B A Virnig, L M Henderson, D S M Buist, K J Wernli, K Kerlikowske, R A Hubbard
PURPOSE: The survival benefit from detecting additional breast cancers by preoperative magnetic resonance imaging (MRI) continues to be controversial. METHODS: We followed a cohort of 4454 women diagnosed with non-metastatic breast cancer (stage I-III) from 2/2005-6/2010 in five registries of the breast cancer surveillance consortium (BCSC). BCSC clinical and registry data were linked to Medicare claims and enrollment data. We estimated the cumulative probability of breast cancer-specific and all-cause mortality...
March 7, 2018: Breast Cancer Research and Treatment
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