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https://www.readbyqxmd.com/read/28070828/hypofractionated-stereotactic-radiosurgery-for-pituitary-metastases
#1
Haemin Chon, KyoungJun Yoon, Do Hoon Kwon, Chang Jin Kim, Min-Seon Kim, Young Hyun Cho
Pituitary metastases (PMs) are uncommon, representing only 1% of pituitary lesions. The diagnosis of PMs can be challenging and an optimal management remains to be determined. Here, we present a pilot clinical study on the efficacy and safety of hypofractionated stereotactic radiosurgery (SRS) with an optimized dosimetric plan in treating PMs. Between June 2013 and December 2014, seven consecutive patients (4 men and 3 women; median age 62 years) had been diagnosed with PMs based on their characteristic clinical and radiological features and subsequently treated using hypofractionated SRS...
January 9, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28066808/effect-of-mr-imaging-contrast-thresholds-on-prediction-of-neoadjuvant-chemotherapy-response-in-breast-cancer-subtypes-a-subgroup-analysis-of-the-acrin-6657-i-spy-1-trial
#2
Wen Li, Vignesh Arasu, David C Newitt, Ella F Jones, Lisa Wilmes, Jessica Gibbs, John Kornak, Bonnie N Joe, Laura J Esserman, Nola M Hylton
Functional tumor volume (FTV) measurements by dynamic contrast-enhanced magnetic resonance imaging can predict treatment outcomes for women receiving neoadjuvant chemotherapy for breast cancer. Here, we explore whether the contrast thresholds used to define FTV could be adjusted by breast cancer subtype to improve predictive performance. Absolute FTV and percent change in FTV (ΔFTV) at sequential time-points during treatment were calculated and investigated as predictors of pathologic complete response at surgery...
December 2016: Tomography: a Journal for Imaging Research
https://www.readbyqxmd.com/read/28048929/su-c-207b-04-automated-segmentation-of-pectoral-muscle-in-mr-images-of-dense-breasts
#3
E Verburg, S N de Waard, W B Veldhuis, C H van Gils, Kga Gilhuijs
PURPOSE: To develop and evaluate a fully automated method for segmentation of the pectoral muscle boundary in Magnetic Resonance Imaging (MRI) of dense breasts. METHODS: Segmentation of the pectoral muscle is an important part of automatic breast image analysis methods. Current methods for segmenting the pectoral muscle in breast MRI have difficulties delineating the muscle border correctly in breasts with a large proportion of fibroglandular tissue (i.e., dense breasts)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048384/su-d-207b-06-predicting-breast-cancer-malignancy-on-dce-mri-data-using-pre-trained-convolutional-neural-networks
#4
N Antropova, B Huynh, M Giger
PURPOSE: We investigate deep learning in the task of distinguishing between malignant and benign breast lesions on dynamic contrast-enhanced MR images (DCE-MRIs), eliminating the need for lesion segmentation and extraction of tumor features. We evaluate convolutional neural network (CNN) after transfer learning with ImageNet, a database of thousands of non-medical images. METHODS: Under a HIPAA-compliant IRB protocol, a database of 551 (357 malignant and 194 benign) breast MRI cases was collected...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048140/mo-fg-campus-jep2-05-mri-guided-single-fraction-boost-delivery-on-individual-axillary-lymph-nodes
#5
T C F van Heijst, N Hoekstra, M E P Philippens, D Eschbach, J J W Lagendijk, H J G D van den Bongard, B van Asselen
PURPOSE: The Utrecht MRI-linac (MRL) design enables new MR-guided radiotherapy (RT) approaches. This is a feasibility study for a single-fraction high dose (boost) to individual lymph nodes (LNs) in breast-cancer patients, after breast-conserving surgery (BCS) and hypofractionated whole-breast irradiation (WBI) with conventional axillary RT (AxRT). METHODS: After written informed consent, 5 breast-cancer patients (cT1-3N0) were enrolled (NL500460.041.14 trial) and underwent 1...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047704/su-g-jep2-05-dose-effects-of-a-1-5t-magnetic-field-on-air-tissue-and-lung-tissue-interfaces-in-mri-guided-radiotherapy
#6
Xinfeng Chen, Phillip Prior, Guangpei Chen, Christopher Schultz, X Allen Li
PURPOSE: The purpose of the study is to investigate the dose effects of electron-return-effect (ERE) at air-tissue and lung-tissue interfaces under a 1.5T transverse-magnetic-field (TMF). METHODS: IMRT and VMAT plans for representative pancreas, lung, breast and head & neck (H&N) cases were generated following clinical dose volume (DV) criteria. The air-cavity walls, as well as the lung wall, were delineated to examine the ERE. In each case, the original plan generated without TMF is compared with the reconstructed plan (generated by recalculating the original plan with the presence of TMF) and the optimized plan (generated by a full optimization with TMF), using a variety of DV parameters, including V100%, D95% and dose heterogeneity index for PTV, Dmax, and D1cc for OARs (organs at risk) and tissue interface...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046969/su-d-207b-04-morphological-features-of-mri-as-a-correlate-of-capsular-contracture-in-breast-cancer-patients-with-implant-based-reconstructions
#7
N Tyagi, E Sutton, M Hunt, A Apte, J Zhang, J Oh, J Mechalakos, B Mehrara, E Matros, A Ho
PURPOSE: Capsular contracture (CC) is a serious complication in patients receiving implant-based reconstruction for breast cancer. The goal of this study was to identify image-based correlates of CC using MRI imaging in breast cancer patients who received both MRI and clinical evaluation following reconstructive surgery. METHODS: We analyzed a retrospective dataset of 50 patients who had both a diagnostic MR and a plastic surgeon's evaluations of CC score (Baker's score) within a six month period following mastectomy and reconstructive surgery...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046496/tu-h-bra-09-relationship-between-b0-and-the-contrast-to-noise-ratio-cnr-of-tumour-to-background-for-mri-radiotherapy-hybrids
#8
K Wachowicz, N DeZanche, E Yip, V Volotovskyy, B Fallone
PURPOSE: To investigate the relationship in MRI between B0 and the contrast-to-noise ratio (CNR) of various tumour/normal tissue pairs. This study is motivated by the current interest in MRI/radiotherapy hybrids, for which multiple magnetic field strengths have been proposed. CNR is the single most important parameter governing the ability of a system to identify a tumour in real time for treatment guidance. The MRI community has long since recognized that the SNR of a well-designed MR system is roughly proportional to B0 , the polarizing magnetic field...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046345/su-f-r-26-prognostic-radiomics-of-breast-cancer-on-dce-and-dwi-mr-images
#9
N Maforo, H Li, L Lan, A Edwards, M L Giger
PURPOSE: For this study, we investigated quantitative radiomics of breast tumors on diffusion weighted imaging and dynamic contrast-enhanced MRIs in the task of assessing the prognostic status of breast cancers. METHODS: Our IRB-approved, retrospectively-collected dataset included 316 breast cancers with 235 ER+ and 81 ER- cases. All images were acquired during clinical breast MRI incorporating dynamic-contrast MRI and diffusion-weighted MRI. Phenotypic categories extracted quantitatively from DCE-MRI included tumor size, shape, margin sharpness, enhancement texture, kinetics, and variance kinetics, and from DWI-DCE ADC features (average, range, variation) for DWI...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27981485/-1-h-mr-spectroscopy-of-suspicious-breast-mass-lesions-at-3t-a-clinical-experience
#10
Stefania Montemezzi, Carlo Cavedon, Lucia Camera, Gabriele Meliadò, Francesca Caumo, Ilaria Baglio, Francesco Sardanelli
OBJECTIVES: To test 3T proton magnetic resonance spectroscopy ((1)H-MRS) for breast mass lesions. METHODS: Patients with BI-RADS 4-5 lesions at mammography/ultrasound were prospectively enrolled. After contrast-enhanced breast MRI, single-voxel MRS (point-resolved volume selection, PRESS); pencil-beam shimming; volume of interest 1 cm(3); TR/TE = 3000/135 ms) was performed. Spectra were considered reliable if the full width at half maximum (FWHM) of the water peak was ≤45 Hz...
December 15, 2016: La Radiologia Medica
https://www.readbyqxmd.com/read/27951458/clinical-applicability-and-relevance-of-fibroglandular-tissue-segmentation-on-routine-t1-weighted-breast-mri
#11
Akshat C Pujara, Artem Mikheev, Henry Rusinek, Harikrishna Rallapalli, Jerzy Walczyk, Yiming Gao, Chloe Chhor, Kristine Pysarenko, James S Babb, Amy N Melsaether
PURPOSE: To evaluate clinical applicability of fibroglandular tissue (FGT) segmentation on routine T1 weighted breast MRI and compare FGT quantification with radiologist assessment. METHODS: FGT was segmented on 232 breasts and quantified, and was assessed qualitatively by four breast imagers. RESULTS: FGT segmentation was successful in all 232 breasts. Agreement between radiologists and quantified FGT was moderate to substantial (kappa=0...
December 6, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27925480/evaluation-of-background-parenchymal-enhancement-on-breast-mri-a-systematic-review
#12
Bianca Bignotti, Alessio Signori, Francesca Valdora, Federica Rossi, Massimo Calabrese, Manuela Durando, Giovanna Mariscotti, Alberto Tagliafico
OBJECTIVES: To perform a systematic review of the methods used for background parenchymal enhancement (BPE) evaluation on breast magnetic resonance imaging (MRI). METHODS: Studies dealing with BPE assessment on breast MRI were retrieved from major medical libraries independently by four reviewers up to 6 October 2015. The keywords used for database searching are "background parenchymal enhancement', 'parenchymal enhancement', "MRI" and "breast". The studies were included if a qualitative and/or quantitative methods for BPE assessment were described...
December 7, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27901596/magnetic-resonance-imaging-in-the-pre-surgical-staging-of-breast-cancer-our-experience
#13
Paola Rabasco, Rocchina Caivano, Giuseppina Dinardo, Matilde Gioioso, Antonella Lotumolo, Giancarlo Iannelli, Antonio Villonio, Giuseppe La Torre, Stefano D'Errico, Luca Macarini, Giuseppe Guglielmi, Aldo Cammarota
PURPOSE: To investigate the clinical impact of magnetic resonance imaging (MRI) in the detection of multifocal-multicentric breast cancers, already identified by mammography and ultrasound, and analyzed histologically, to evaluate its role in preoperative staging. MATERIALS AND METHODS: From January 2012 to February 2014, 188 patients, aged 28 to 74 years, newly diagnosed with breast cancer on conventional imaging (mammography and ultrasound) were enrolled. They underwent preoperative contrast-enhanced 3T MRI...
November 30, 2016: Cancer Investigation
https://www.readbyqxmd.com/read/27896640/role-of-axillary-ultrasound-magnetic-resonance-imaging-and-ultrasound-guided-fine-needle-aspiration-biopsy-in-the-preoperative-triage-of-breast-cancer-patients
#14
I Barco, C Chabrera, A García-Fernández, M Fraile, S González, L Canales, J M Lain, C González, M C Vidal, E Vallejo, J Deu, A Pessarrodona, N Giménez, M García Font
PURPOSE: Roughly two-thirds of early breast cancer cases are associated with negative axillary nodes and do not benefit from axillary surgery at all. Accordingly, there is an ongoing search for non-surgical staging procedures to avoid lymph-node dissection or sentinel node biopsy (SNB). Non-invasive imaging techniques with very high sensitivity (Se) and negative predictive value (NPV) could eventually replace SNB. We aimed to establish the role of axillary US and MRI, alone or in combination, associated with ultrasound-guided fine-needle aspiration biopsy (US-FNAB) in the prediction of axillary node involvement...
November 28, 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27895875/takeaways-from-pre-contrast-t1-and-t2-breast-magnetic-resonance-imaging-in-women-with-recently-diagnosed-breast-cancer
#15
Seung Hee Han, Yeong Yi An, Bong Joo Kang, Sung Hun Kim, Eun Jae Lee
BACKGROUND: Dynamic contrast-enhanced magnetic resonance imaging (DCE - MRI) has been widely used in the management of breast cancer, and its diagnostic value in breast imaging has been demonstrated. There have only been a few reports regarding the usefulness of pre-contrast imaging. Knowledge about clinically significant findings of preoperative, pre-contrast T1 and T2 MR images will allow more accurate decisions regarding patient treatment and management. OBJECTIVES: The aim of this study was to evaluate the clinically significant findings of preoperative, pre-contrast T1 and T2 MR images in recently diagnosed breast cancer patients...
October 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27888545/anti-angiogenic-therapy-affects-the-relationship-between-tumor-vascular-structure-and-function-a-correlation-study-between-micro-computed-tomography-angiography-and-dynamic-contrast-enhanced-mri
#16
Eugene Kim, Jana Kim, Gunhild Mari Maelandsmo, Berit Johansen, Siver Andreas Moestue
PURPOSE: To compare the effects of two anti-angiogenic drugs, bevacizumab and a cytosolic phospholipase A2-α inhibitor (AVX235), on the relationship between vascular structure and dynamic contrast enhanced (DCE)-MRI measurements in a patient-derived breast cancer xenograft model. METHODS: Mice bearing MAS98.12 tumors were randomized into three groups: bevacizumab-treated (n = 9), AVX235-treated (n = 9), and control (n = 8). DCE-MRI was performed pre- and post-treatment...
November 25, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27885679/clinical-auditing-as-an-instrument-for-quality-improvement-in-breast-cancer-care-in-the-netherlands-the-national-nabon-breast-cancer-audit
#17
Annelotte C M van Bommel, Pauline E R Spronk, Marie-Jeanne T F D Vrancken Peeters, Agnes Jager, Marc Lobbes, John H Maduro, Marc A M Mureau, Kay Schreuder, Carolien H Smorenburg, Janneke Verloop, Pieter J Westenend, Michel W J M Wouters, Sabine Siesling, Vivianne C G Tjan-Heijnen, Thijs van Dalen
BACKGROUND: In 2011, the NABON Breast Cancer Audit (NBCA) was instituted as a nation-wide audit to address quality of breast cancer care and guideline adherence in the Netherlands. The development of the NBCA and the results of 4 years of auditing are described. METHODS: Clinical and pathological characteristics of patients diagnosed with invasive breast cancer or in situ carcinoma (DCIS) and information regarding diagnosis and treatment are collected in all hospitals (n = 92) in the Netherlands...
November 25, 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27875760/comparing-cancer-detection-rates-of-patients-undergoing-short-term-follow-up-vs-routine-follow-up-after-benign-breast-biopsies-is-follow-up-needed
#18
Donna M Plecha, Courtney Garlick, Christina Dubchuck, Cheryl Thompson, Niki Constantinou
PURPOSE: To compare cancer rates after benign breast biopsies between patients with short term imaging follow-up (STFU) and those with routine follow-up (RFU). MATERIALS & METHODS: Retrospective review of benign stereotactic, US or DCE-MRI breast biopsies. RESULTS: Of 580 lesions, 192 (33%) had STFU, and 388 (67%) had RFU. For US and mammographic detected lesions, there is no difference in cancer rates between the STFU (1 cancer, n=148) and the RFU group (0 cancer, n=365) (p=0...
November 16, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27859874/comparison-of-conventional-dce-mri-and-a-novel-golden-angle-radial-multicoil-compressed-sensing-method-for-the-evaluation-of-breast-lesion-conspicuity
#19
Laura Heacock, Yiming Gao, Samantha L Heller, Amy N Melsaether, James S Babb, Tobias K Block, Ricardo Otazo, Sungheon G Kim, Linda Moy
PURPOSE: To compare a novel multicoil compressed sensing technique with flexible temporal resolution, golden-angle radial sparse parallel (GRASP), to conventional fat-suppressed spoiled three-dimensional (3D) gradient-echo (volumetric interpolated breath-hold examination, VIBE) MRI in evaluating the conspicuity of benign and malignant breast lesions. MATERIALS AND METHODS: Between March and August 2015, 121 women (24-84 years; mean, 49.7 years) with 180 biopsy-proven benign and malignant lesions were imaged consecutively at 3...
November 17, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27853653/dense-breast-tissue-in-postmenopausal-women-is-associated-with-a-pro-inflammatory-microenvironment-in-vivo
#20
Annelie Abrahamsson, Anna Rzepecka, Thobias Romu, Magnus Borga, Olof Dahlqvist Leinhard, Peter Lundberg, Johan Kihlberg, Charlotta Dabrosin
Inflammation is one of the hallmarks of carcinogenesis. High mammographic density has been associated with increased risk of breast cancer but the mechanisms behind are poorly understood. We evaluated whether breasts with different mammographic densities exhibited differences in the inflammatory microenvironment. Postmenopausal women attending the mammography-screening program were assessed having extreme dense, n = 20, or entirely fatty breasts (nondense), n = 19, on their regular mammograms. Thereafter, the women were invited for magnetic resonance imaging (MRI), microdialysis for the collection of extracellular molecules in situ and a core tissue biopsy for research purposes...
2016: Oncoimmunology
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