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https://www.readbyqxmd.com/read/28643383/multiecho-pseudo-golden-angle-stack-of-stars-thermometry-with-high-spatial-and-temporal-resolution-using-k-space-weighted-image-contrast
#1
Bryant T Svedin, Allison Payne, Bradley D Bolster, Dennis L Parker
PURPOSE: Implement and evaluate a 3D MRI method to measure temperature changes with high spatial and temporal resolution and large field of view. METHODS: A multiecho pseudo-golden angle stack-of-stars (SOS) sequence with k-space weighted image contrast (KWIC) reconstruction was implemented to simultaneously measure multiple quantities, including temperature, initial signal magnitude M(0), transverse relaxation time ( T2*), and water/fat images. Respiration artifacts were corrected using self-navigation...
June 22, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28627463/pre-operative-assessment-of-residual-disease-in-locally-advanced-breast-cancer-patients-a-sequential-study-by-quantitative-diffusion-weighted-mri-as-a-function-of-therapy
#2
Khushbu Agarwal, Uma Sharma, Rani G Sah, Sandeep Mathur, Smriti Hari, Vurthaluru Seenu, Rajinder Parshad, Naranamangalam R Jagannathan
PURPOSE: The potential of diffusion weighted imaging (DWI) in assessing pathologic response and surgical margins in locally advanced breast cancer patients (n=38) undergoing neoadjuvant chemotherapy was investigated. METHODS: DWI was performed at pre-therapy (Tp0), after I (Tp1) and III (Tp3) NACT at 1.5T. Apparent diffusion coefficient (ADC) of whole tumor (ADCWT), solid tumor (ADCST), intra-tumoral necrosis (ADCNec) was determined. Further, ADC of 6 consecutive shells (5mm thickness each) including tumor margin to outside tumor margins (OM1 to OM5) was calculated and the data analyzed to define surgical margins...
June 13, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28610412/diagnostic-value-of-diffusion-weighted-magnetic-resonance-imaging-in-evaluation-of-metastatic-axillary-lymph-nodes-in-a-sample-of-iranian-women-with-breast-cancer
#3
Fereshteh Hasanzadeh, Fariborz Faeghi, Abdollah Valizadeh, Leyla Bayani
Objective: To evaluate the diagnostic value of diffusion weighted magnetic resonance imaging (DW-MRI) in assessment of metastases in axillary lymph nodes (ALNs) in a sample of Iranian women with breast cancer. Methods: A total of 50 axillary lymph nodes from 30 female patients with histologically verified breast cancer were assessed by 1.5 T MRI. DWI was implemented at b-values of 50, 400 and 800 s/mm2. Short axis diameter, presence of fatty hilum and apparent diffusion coefficient (ADC) values (min, max and mean) of metastatic and non-metastatic ALNs was compared...
May 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28600647/hybrid-18-f-fdg-pet-mri-might-improve-locoregional-staging-of-breast-cancer-patients-prior-to-neoadjuvant-chemotherapy
#4
Briete Goorts, Stefan Vöö, Thiemo J A van Nijnatten, Loes F S Kooreman, Maaike de Boer, Kristien B M I Keymeulen, Romy Aarnoutse, Joachim E Wildberger, Felix M Mottaghy, Marc B I Lobbes, Marjolein L Smidt
PURPOSE: Our purpose in this study was to assess the added clinical value of hybrid (18)F-FDG-PET/MRI compared to conventional imaging for locoregional staging in breast cancer patients undergoing neoadjuvant chemotherapy (NAC). METHODS: In this prospective study, primary invasive cT2-4 N0 or cT1-4 N+ breast cancer patients undergoing NAC were included. A PET/MRI breast protocol was performed before treatment. MR images were evaluated by a breast radiologist, blinded for PET images...
June 10, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28599842/composite-breast-reconstruction-implant-based-breast-reconstruction-with%C3%A2-adjunctive-lipofilling
#5
C E Sommeling, K Van Landuyt, H Depypere, R Van den Broecke, S Monstrey, P N Blondeel, W A Morrison, F B Stillaert
INTRODUCTION: Options for breast reconstructions enclose autologous tissue transfers or implants. Fat grafting is gaining more interest in this specific field of breast surgery. This study concentrates on the technique and aesthetic results of breast reconstruction with fat grafts combined with implants, in women who have undergone total mastectomy. METHODS: Breast reconstructions (n = 23) was performed using a protocol of intratissular expansion with serial deflation-lipofilling...
May 22, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28583631/repeated-surgeries-in-invasive-lobular-breast-cancer-with-preoperative-mri-role-of-additional-carcinoma-in-situ-and-background-parenchymal-enhancement
#6
H Preibsch, V Richter, S D Bahrs, V Hattermann, B M Wietek, G Bier, C Kloth, G Blumenstock, M Hahn, A Staebler, K Nikolaou, B Wiesinger
OBJECTIVES: Analysing the influence of additional carcinoma in situ (CIS) and background parenchymal enhancement (BPE) in preoperative MRI on repeated surgeries in patients with invasive lobular carcinoma (ILC) of the breast. METHODS: Retrospective analysis of 106 patients (mean age 58.6±9.9years) with 108 ILC. Preoperative tumour size as assessed by MRI, mammography and sonography was recorded and compared to histopathology. In contrast-enhanced MRI, the degree of BPE was categorised by two readers...
May 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28560655/a-randomized-placebo-controlled-trial-of-diindolylmethane-for-breast-cancer-biomarker-modulation-in-patients-taking-tamoxifen
#7
Cynthia A Thomson, H H Sherry Chow, Betsy C Wertheim, Denise J Roe, Alison Stopeck, Gertraud Maskarinec, Maria Altbach, Pavani Chalasani, Chuan Huang, Meghan B Strom, Jean-Philippe Galons, Patricia A Thompson
PURPOSE: Diindolylmethane (DIM), a bioactive metabolite of indole-3-carbinol found in cruciferous vegetables, has proposed cancer chemoprevention activity in the breast. There is limited evidence of clinically relevant activity of DIM or long-term safety data of its regular use. A randomized, double-blind, placebo-controlled trial was conducted to determine the activity and safety of combined use of BioResponse DIM® (BR-DIM) with tamoxifen. METHODS: Women prescribed tamoxifen (n = 130) were randomly assigned oral BR-DIM at 150 mg twice daily or placebo, for 12 months...
May 30, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28537753/radiologic-pathologic-correlation-for-benign-results-after-mri-guided-breast-biopsy
#8
Katharine D Maglione, Amie Y Lee, Kimberly M Ray, Bonnie N Joe, Ronald Balassanian
OBJECTIVE: The majority of MRI-guided breast biopsies yield benign pathology. The purpose of this article is to provide a comprehensive overview of benign pathologic entities commonly encountered at MRI-guided breast biopsy. CONCLUSION: Proper radiologic-pathologic correlation is an integral component of MRI-guided breast biopsy. Familiarity with the spectrum of MRI findings and key histopathologic features of common benign entities will enhance the radiologist's confidence in determining concordance and lead to improved patient management recommendations...
May 24, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28521821/intratumoral-and-peritumoral-radiomics-for-the-pretreatment-prediction-of-pathological-complete-response-to-neoadjuvant-chemotherapy-based-on-breast-dce-mri
#9
Nathaniel M Braman, Maryam Etesami, Prateek Prasanna, Christina Dubchuk, Hannah Gilmore, Pallavi Tiwari, Donna Pletcha, Anant Madabhushi
BACKGROUND: In this study, we evaluated the ability of radiomic textural analysis of intratumoral and peritumoral regions on pretreatment breast cancer dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to predict pathological complete response (pCR) to neoadjuvant chemotherapy (NAC). METHODS: A total of 117 patients who had received NAC were retrospectively analyzed. Within the intratumoral and peritumoral regions of T1-weighted contrast-enhanced MRI scans, a total of 99 radiomic textural features were computed at multiple phases...
May 18, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28511975/leptomeningeal-failure-in-patients-with-breast-cancer-receiving-stereotactic-radiosurgery-for-brain-metastases
#10
REVIEW
Edina C Wang, Andrew J Huang, Karen E Huang, Emory R McTyre, Hui-Wen Lo, Kounosuke Watabe, Linda Metheny-Barlow, Adrian W Laxton, Stephen B Tatter, Roy E Strowd, Michael D Chan, Brandi R Page
PURPOSE: Prior studies suggest a high incidence of leptomeningeal failure (LMF) in breast cancer metastatic to brain. This study examines breast cancer-specific variables affecting development of LMF and survival after Gamma-Knife Radiosurgery (GKS). METHODS: Between 2000-2010, 149 (breast) and 658 other-histology patients were treated with GKS. Hormone/HER2, age, local/distant brain failure, prior craniotomy, and prior whole-brain radiotherapy (WBRT) were assessed...
May 13, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28487252/capecitabine-induced-acute-toxic-leukoencephalopathy
#11
M Obadia, D Leclercq, Johanna Wasserman, D Galanaud, D Dormont, M Sahli-Amor, Dimitri Psimaras, N Pyatigorskaya, B Law-Ye
A 45-year-old woman was treated by Capecitabine (Xeloda(®)) during 6days for breast cancer with metastatic bone lesions when she presented with nausea, headaches, muscle cramps, dysarthria and swallowing disorders. A stroke was first suspected. Brain CT was normal. MRI showed bilateral and symmetric high signal intensities of deep white matter, corpus callosum and corticospinal tracts on diffusion-weighted imaging and T2 fluid-attenuated inversion recovery (FLAIR) sequence, similar to 5-FU acute leukoencephalopathy...
May 6, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28463932/compressed-sensing-for-breast-mri-resolving-the-trade-off-between-spatial-and-temporal-resolution
#12
Suzan Vreemann, Alejandro Rodriguez-Ruiz, Dominik Nickel, Laura Heacock, Linda Appelman, Jan van Zelst, Nico Karssemeijer, Elisabeth Weiland, Marnix Maas, Linda Moy, Berthold Kiefer, Ritse M Mann
OBJECTIVE: Ultrafast dynamic contrast-enhanced magnetic resonance imaging of the breast enables assessment of the contrast inflow dynamics while providing images with diagnostic spatial resolution. However, the slice thickness of common ultrafast techniques still prevents multiplanar reconstruction. In addition, some temporal blurring of the enhancement characteristics occurs in case view-sharing is used. We evaluate a prototype compressed-sensing volume-interpolated breath-hold examination (CS-VIBE) sequence for ultrafast breast MRI that improves through plane spatial resolution and avoids temporal blurring while maintaining an ultrafast temporal resolution (less than 5 seconds per volume)...
May 1, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28450563/sstr-mediated-breast-cancer-imaging-is-there-a-role-for-radiolabeled-sstr-antagonists
#13
Simone U Dalm, Joost Haeck, Gabriela N Doeswijk, Erik de Blois, Marion de Jong, Carolien van Deurzen
INTRODUCTION: Recent studies showed enhanced tumor targeting by novel somatostatin receptor (SSTR) antagonists compared to clinically widely used agonists. However, these results have mostly been obtained in neuroendocrine tumors and only limited data is available for cancer types with lower SSTR expression, including breast cancer (BC). To date, only two studies reported higher binding of the antagonist versus the agonist in BC, but in both studies a limited number of cases were evaluated. In this pre-clinical study, we further investigated whether the application of a SSTR antagonist could improve SSTR-mediated BC imaging in a large panel of BC specimens...
April 27, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28433532/exci-cest-exploiting-pharmaceutical-excipients-as-mri-cest-contrast-agents-for-tumor-imaging
#14
Dario Livio Longo, Fatima Zzahra Moustaghfir, Alexandre Zerbo, Lorena Consolino, Annasofia Anemone, Martina Bracesco, Silvio Aime
Chemical Exchange Saturation Transfer (CEST) approach is a novel tool within magnetic resonance imaging (MRI) that allows visualization of molecules possessing exchangeable protons with water. Many molecules, employed as excipients for the formulation of finished drug products, are endowed with hydroxyl, amine or amide protons, thus can be exploitable as MRI-CEST contrast agents. Their high safety profiles allow them to be injected at very high doses. Here we investigated the MRI-CEST properties of several excipients (ascorbic acid, sucrose, N-acetyl-d-glucosamine, meglumine and 2-pyrrolidone) and tested them as tumor-detecting agents in two different murine tumor models (breast and melanoma cancers)...
April 20, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28383841/-atypical-presentation-of-a-breast-cancer-pituitary-metastasis
#15
J Langrand-Escure, A Vallard, J-Ph Suchaud, P Diao, N Magné
Pituitary metastasis occur in 1-5 % of patients with cancer. We report the discovery of a unique pituitary metastasis of breast cancer. A 67 years old woman was treated in 2003 for local adenocarcinoma. After bone metastatic relapse in 2008, the patient developed diplopia and diabetes insipidus. An MRI revealed a histologically proven metastatic pituitary nodule. Further explorations revealed failure of multiple endocrine axes. Pituitary metastases are relatively rare, but are probably under-diagnosed in the presence of advanced cancers with impaired general condition...
July 2016: Revue Médicale de Liège
https://www.readbyqxmd.com/read/28383279/accuracy-of-diffusion-kurtosis-imaging-in-characterization-of-breast-lesions
#16
Alexandra Christou, Abraham Ghiatas, Dimitrios Priovolos, Konstantia Veliou, Haralambos Bougias
OBJECTIVE: The aim of this study was to evaluate the accuracy of diffusion kurtosis in the characterization and differentiation of breast lesions. METHODS: 49 females with 53 breast lesions underwent breast MRI. The MRI magnetic field is 1.5 T, and the protocol is standard MRI sequences, dynamic sequences pre- and post-contrast agent administration and diffusion images. Diffusion kurtosis imaging (DKI) was applied as part of our standard breast MRΙ protocol. Two experienced radiologists on breast MRI, blinded to the final diagnosis, reviewed the parametric maps and placed a volume of interest on all slices including each lesion...
May 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28370289/estimating-breast-tumor-blood-flow-during-neoadjuvant-chemotherapy-using-interleaved-high-temporal-and-high-spatial-resolution-mri
#17
Leonidas Georgiou, Nisha Sharma, David A Broadbent, Daniel J Wilson, Barbara J Dall, Anmol Gangi, David L Buckley
PURPOSE: To evaluate an interleaved MRI sampling strategy that acquires both high temporal resolution (HTR) dynamic contrast-enhanced (DCE) data for quantifying breast tumor blood flow (TBF) and high spatial resolution (HSR) DCE data for clinical reporting, following a single standard injection of contrast agent. METHODS: A simulation study was used to evaluate the performance of the interleaved technique under different conditions. In a prospective clinical study, 18 patients with primary breast cancer, who were due to undergo neoadjuvant chemotherapy (NACT), were examined using interleaved HTR and HSR DCE-MRI at 1...
April 3, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28366759/mri-ductography-of-contrast-agent-distribution-and-leakage-in-normal-mouse-mammary-ducts-and-ducts-with-in-situ-cancer
#18
Erica Markiewicz, Xiaobing Fan, Devkumar Mustafi, Marta Zamora, Suzanne D Conzen, Gregory S Karczmar
High resolution 3D MRI was used to study contrast agent distribution and leakage in normal mouse mammary glands and glands containing in situ cancer after intra-ductal injection. Five female FVB/N mice (~19weeks old) with no detectable mammary cancer and eight C3(1) SV40 Tag virgin female mice (~15weeks old) with extensive in situ cancer were studied. A 34G, 45° tip Hamilton needle with a 25μL Hamilton syringe was inserted into the tip of the nipple and approximately 15μL of a Gadodiamide was injected slowly over 1min into the nipple and throughout the duct on one side of the inguinal gland...
July 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28364724/magnetic-resonance-imaging-characteristics-of-granulomatous-mastitis
#19
Amanda N Chu, Stephen J Seiler, Jody C Hayes, Rachel Wooldridge, Jessica H Porembka
Granulomatous mastitis (GM) is a benign chronic inflammatory condition of the breast. This study was performed to determine the utility of magnetic resonance imaging (MRI) in differentiating GM from malignancy. MRI findings in 12 women with clinical or histopathologically-proven GM were retrospectively reviewed. Non-mass enhancement on MRI was present in all 12 patients with clustered ring enhancement being the most common pattern (n=7, 58%). Architectural distortion (n=10, 83%), skin thickening (n=10, 83%) and focal skin enhancement (n=10, 83%) were also very common...
May 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28349273/background-parenchymal-enhancement-on-breast-mri-association-with-recurrence-free-survival-in-patients-with-newly-diagnosed-invasive-breast-cancer
#20
Yaeji Lim, Eun Sook Ko, Boo-Kyung Han, Eun Young Ko, Ji Soo Choi, Jeong Eon Lee, Se Kyung Lee
PURPOSE: To determine whether BPE in preoperative breast MRI influences patients' recurrence-free survival (RFS). METHODS: Between February 2010 and December 2011, 804 consecutive women with invasive breast cancer who had undergone preoperative breast MRI and curative cancer surgery were identified. BPE was visually graded by two reviewers. We determined the correlation between BPE grade and other clinicopathological variables, including age, adjuvant therapy, menopausal status, histologic grade, T stage, N stage, lymphovascular invasion, molecular subtype, surgical margin status, and mammographic density...
March 27, 2017: Breast Cancer Research and Treatment
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