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https://www.readbyqxmd.com/read/28383841/-atypical-presentation-of-a-breast-cancer-pituitary-metastasis
#1
J Langrand-Escure, A Vallard, J-Ph Suchaud, P Diao, N Magné
Pituitary metastasis occur in 1-5 % of patients with cancer. We report the discovery of a unique pituitary metastasis of breast cancer. A 67 years old woman was treated in 2003 for local adenocarcinoma. After bone metastatic relapse in 2008, the patient developed diplopia and diabetes insipidus. An MRI revealed a histologically proven metastatic pituitary nodule. Further explorations revealed failure of multiple endocrine axes. Pituitary metastases are relatively rare, but are probably under-diagnosed in the presence of advanced cancers with impaired general condition...
July 2016: Revue Médicale de Liège
https://www.readbyqxmd.com/read/28383279/accuracy-of-diffusion-kurtosis-imaging-in-characterization-of-breast-lesions
#2
Alexandra Christou, Abraham Ghiatas, Dimitrios Priovolos, Konstantia Veliou, Haralambos Bougias
OBJECTIVE: The aim of this study was to evaluate the accuracy of diffusion kurtosis in the characterization and differentiation of breast lesions. METHODS: 49 females with 53 breast lesions underwent breast MRI. The MRI magnetic field is 1.5 T, and the protocol is standard MRI sequences, dynamic sequences pre- and post-contrast agent administration and diffusion images. Diffusion kurtosis imaging (DKI) was applied as part of our standard breast MRΙ protocol. Two experienced radiologists on breast MRI, blinded to the final diagnosis, reviewed the parametric maps and placed a volume of interest on all slices including each lesion...
May 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28370289/estimating-breast-tumor-blood-flow-during-neoadjuvant-chemotherapy-using-interleaved-high-temporal-and-high-spatial-resolution-mri
#3
Leonidas Georgiou, Nisha Sharma, David A Broadbent, Daniel J Wilson, Barbara J Dall, Anmol Gangi, David L Buckley
PURPOSE: To evaluate an interleaved MRI sampling strategy that acquires both high temporal resolution (HTR) dynamic contrast-enhanced (DCE) data for quantifying breast tumor blood flow (TBF) and high spatial resolution (HSR) DCE data for clinical reporting, following a single standard injection of contrast agent. METHODS: A simulation study was used to evaluate the performance of the interleaved technique under different conditions. In a prospective clinical study, 18 patients with primary breast cancer, who were due to undergo neoadjuvant chemotherapy (NACT), were examined using interleaved HTR and HSR DCE-MRI at 1...
April 3, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28366759/mri-ductography-of-contrast-agent-distribution-and-leakage-in-normal-mouse-mammary-ducts-and-ducts-with-in-situ-cancer
#4
Erica Markiewicz, Xiaobing Fan, Devkumar Mustafi, Marta Zamora, Suzanne D Conzen, Gregory S Karczmar
High resolution 3D MRI was used to study contrast agent distribution and leakage in normal mouse mammary glands and glands containing in situ cancer after intra-ductal injection. Five female FVB/N mice (~19weeks old) with no detectable mammary cancer and eight C3(1) SV40 Tag virgin female mice (~15weeks old) with extensive in situ cancer were studied. A 34G, 45° tip Hamilton needle with a 25μL Hamilton syringe was inserted into the tip of the nipple and approximately 15μL of a Gadodiamide was injected slowly over 1min into the nipple and throughout the duct on one side of the inguinal gland...
March 30, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28364724/magnetic-resonance-imaging-characteristics-of-granulomatous-mastitis
#5
Amanda N Chu, Stephen J Seiler, Jody C Hayes, Rachel Wooldridge, Jessica H Porembka
Granulomatous mastitis (GM) is a benign chronic inflammatory condition of the breast. This study was performed to determine the utility of magnetic resonance imaging (MRI) in differentiating GM from malignancy. MRI findings in 12 women with clinical or histopathologically-proven GM were retrospectively reviewed. Non-mass enhancement on MRI was present in all 12 patients with clustered ring enhancement being the most common pattern (n=7, 58%). Architectural distortion (n=10, 83%), skin thickening (n=10, 83%) and focal skin enhancement (n=10, 83%) were also very common...
March 15, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28349273/background-parenchymal-enhancement-on-breast-mri-association-with-recurrence-free-survival-in-patients-with-newly-diagnosed-invasive-breast-cancer
#6
Yaeji Lim, Eun Sook Ko, Boo-Kyung Han, Eun Young Ko, Ji Soo Choi, Jeong Eon Lee, Se Kyung Lee
PURPOSE: To determine whether BPE in preoperative breast MRI influences patients' recurrence-free survival (RFS). METHODS: Between February 2010 and December 2011, 804 consecutive women with invasive breast cancer who had undergone preoperative breast MRI and curative cancer surgery were identified. BPE was visually graded by two reviewers. We determined the correlation between BPE grade and other clinicopathological variables, including age, adjuvant therapy, menopausal status, histologic grade, T stage, N stage, lymphovascular invasion, molecular subtype, surgical margin status, and mammographic density...
March 27, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28332033/surgeon-attitudes-and-use-of-mri-in-patients-newly-diagnosed-with-breast-cancer
#7
Monica Morrow, Sarah T Hawley, M Chandler McLeod, Ann S Hamilton, Kevin C Ward, Steven J Katz, Reshma Jagsi
BACKGROUND: Usage of magnetic resonance imaging (MRI) in newly diagnosed breast cancer patients is increasing, despite scant evidence that it improves outcomes. Little is known about the knowledge, perspectives, and clinical characteristics of surgeons associated with MRI use. METHODS: Women with early-stage breast cancer undergoing definitive surgery between July 2013 and August 2015 were identified from the Los Angeles and Georgia Surveillance, Epidemiology and End Results (SEER) registries and were asked to name their attending surgeons...
March 22, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28323572/bilateral-changes-in-deep-tissue-environment-after-manual-lymphatic-drainage-in-patients-with-breast-cancer-treatment-related-lymphedema
#8
Paula M C Donahue, Rachelle Crescenzi, Allison O Scott, Vaughn Braxton, Aditi Desai, Seth A Smith, John Jordi, Ingrid M Meszoely, Ana M Grau, Rondi M Kauffmann, Raeshell S Sweeting, Kandace Spotanski, Sheila H Ridner, Manus J Donahue
BACKGROUND: Breast cancer treatment-related lymphedema (BCRL) arises from a mechanical insufficiency following cancer therapies. Early BCRL detection and personalized intervention require an improved understanding of the physiological processes that initiate lymphatic impairment. Here, internal magnetic resonance imaging (MRI) measures of the tissue microenvironment were paired with clinical measures of tissue structure to test fundamental hypotheses regarding structural tissue and muscle changes after the commonly used therapeutic intervention of manual lymphatic drainage (MLD)...
March 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28315967/relationship-of-breast-mri-to-recurrence-rates-in-patients-undergoing-breast-conservation-treatment
#9
Maureen V Hill, Julia L Beeman, Khushboo Jhala, Stefan D Holubar, Kari M Rosenkranz, Richard J Barth
PURPOSE: The effect of pre-operative MRI on the in-breast tumor recurrence rate (IBTR) of patients undergoing breast-conservation treatment (BCT) remains uncertain. We began to routinely perform pre-operative MRI in 2006. Our goal was to determine the effect of pre-operative MRI on IBTR. METHODS: Retrospective review of a prospective database of all patients undergoing BCT (n = 1396) from 2000 to 2010. IBTR were calculated using Kaplan-Meier estimates. RESULTS: 664 (47...
March 18, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28301933/ferritin-decorated-plga-paclitaxel-loaded-nanoparticles-endowed-with-an-enhanced-toxicity-toward-mcf-7-breast-tumor-cells
#10
Ludmila N Turino, Maria R Ruggiero, Rachele Stefanìa, Juan C Cutrin, Silvio Aime, Simonetta Geninatti Crich
Polylactic and glycolic acid nanoparticles (PLGA-NPs), coated with L-ferritin, are exploited for the simultaneous delivery of paclitaxel and an amphiphilic Gd based MRI contrast agent into breast cancer cells (MCF7). L-ferritin has been covalently conjugated to the external surface of PLGA-NPs exploiting NHS activated carboxylic groups. The results confirmed that nanoparticles decorated with L-ferritin have many advantages with respect to both albumin-decorated and nondecorated particles. Ferritin moieties endow PLGA-NPs with targeting capability, exploiting SCARA5 receptors overexpressed by these tumor cells, that results in an increased paclitaxel cytotoxicity...
March 24, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28295903/feasibility-of-intraoperative-breast-mri-and-the-role-of-prone-versus-supine-positioning-in-surgical-planning-for-breast-conserving-surgery
#11
Melissa A Mallory, Yasuaki Sagara, Fatih Aydogan, Stephen DeSantis, Jagadeesan Jayender, Diana Caragacianu, Eva Gombos, Kirby G Vosburgh, Ferenc A Jolesz, Mehra Golshan
We assessed the feasibility of supine intraoperative MRI (iMRI) during breast-conserving surgery (BCS), enrolling 15 patients in our phase I trial between 2012 and 2014. Patients received diagnostic prone MRI, BCS, pre-excisional supine iMRI, and postexcisional supine iMRI. Feasibility was assessed based on safety, sterility, duration, and image-quality. Twelve patients completed the study; mean duration = 114 minutes; all images were adequate; no complications, safety, or sterility issues were encountered...
March 10, 2017: Breast Journal
https://www.readbyqxmd.com/read/28295791/value-of-breast-mri-for-patients-with-a-biopsy-showing-atypical-ductal-hyperplasia-adh
#12
Keiko Tsuchiya, Naoko Mori, David V Schacht, Deepa Sheth, Gregory S Karczmar, Gillian M Newstead, Hiroyuki Abe
PURPOSE: To evaluate the diagnostic value of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) for patients with atypical ductal hyperplasia (ADH) in predicting malignant upgrade. MATERIALS AND METHODS: 3T DCE-MRI was performed for 17 patients with ADH (median age 52, range 42-76) proven by stereotactic biopsy (n = 15), and ultrasound-guided biopsy (n = 2) from January 2011 to April 2015. All patients underwent surgical excision after the MRI...
March 10, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28290072/changes-in-brain-white-matter-integrity-after-systemic-treatment-for-breast-cancer-a-prospective-longitudinal-study
#13
Sanne Menning, Michiel B de Ruiter, Dick J Veltman, Willem Boogerd, Hester S A Oldenburg, Liesbeth Reneman, Sanne B Schagen
An increasing number of studies suggest chemotherapy for breast cancer may be neurotoxic. Cross-sectional MRI diffusion tensor imaging (DTI) studies suggest a vulnerability of brain white matter to various chemotherapeutic regimens. Up till now, this was confirmed in one prospective DTI study: Deprez et al. (2012) showed a widespread decline in fractional anisotropy (FA) of breast cancer patients after chemotherapy consisting of 5-fluorouracil (5-FU), epirubicin and cyclophosphamide (FEC) +/- taxanes +/- endocrine treatment...
March 13, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28273747/histogram-analysis-of-volume-based-apparent-diffusion-coefficient-in-breast-cancer
#14
Ga Eun Park, Sung Hun Kim, Eun Jeong Kim, Bong Joo Kang, Mi Sun Park
Background Breast cancer is a heterogeneous disease. Recent studies showed that apparent diffusion coefficient (ADC) values have various association with tumor aggressiveness and prognosis. Purpose To evaluate the value of histogram analysis of ADC values obtained from the whole tumor volume in invasive ductal cancer (IDC) and ductal carcinoma in situ (DCIS). Material and Methods This retrospective study included 201 patients with confirmed DCIS (n = 37) and IDC (n = 164). The IDC group was divided into two groups based on the presence of a DCIS component: IDC-DCIS (n = 76) and pure IDC (n = 88)...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28267534/cross-sectional-imaging-to-evaluate-the-extent-of-regional-nodal-disease-in-breast-cancer-patients-undergoing-neoadjuvant-systemic-therapy
#15
Tara L Anderson, Katrina N Glazebrook, Brittany L Murphy, Lyndsay D Viers, Tina J Hieken
PURPOSE: Cross-sectional imaging often is performed in breast cancer patients undergoing neoadjuvant systemic therapy (NST) and may identify level III axillary and extra-axillary nodal disease. Our aim was to investigate associations of radiologic nodal staging with pathological N (pN) stage at operation and to explore how this might aid surgical and radiotherapy treatment planning. MATERIALS AND METHODS: With IRB approval, we reviewed pre-treatment breast MRI, PET/CT, and CT imaging and clinicopathologic data on 348 breast cancer patients with imaging available for review undergoing NST followed by operation at our institution 1/2008-9/2013...
April 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28267372/clinical-utility-of-breast-mri-in-the-diagnosis-of-malignancy-after-inconclusive-or-equivocal-mammographic-diagnostic-evaluation
#16
Catherine S Giess, Sona A Chikarmane, Dorothy A Sippo, Robyn L Birdwell
OBJECTIVE: The purpose of this study was to determine the clinical utility of breast MRI for diagnosing malignancy in women with equivocal mammographic findings but no symptoms. MATERIALS AND METHODS: Retrospective review of an institutional MRI database of 7332 contrast-enhanced breast MRI examinations from January 1, 2009, through December 31, 2012, yielded the records of 296 (4.0%) examinations of 294 women without symptoms who underwent MRI for mammographic findings uncertain at diagnostic evaluation...
March 7, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28267361/volume-navigation-technique-for-ultrasound-guided-biopsy-of-breast-lesions-detected-only-at-mri
#17
Erkin Aribal, Derya Tureli, Fikret Kucukkaya, Handan Kaya
OBJECTIVE: The purpose of this study is to assess the utility of a volume navigation technique (VNT) for ultrasound-guided biopsy of MRI-detected, but sonographically ambiguous or occult, breast lesions. SUBJECTS AND METHODS: Within a recruitment period of 13 months (January 1, 2014, through February 1, 2015), 22 patients with 26 BI-RADS category 4 or 5 lesions that were detected at MRI but missed at second-look ultrasound were reimaged using a rapid sequence and a flexible body coil in a 3-T MRI scanner...
March 7, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28265306/screening-with-magnetic-resonance-imaging-mammography-and-ultrasound-in-women-at-average-and-intermediate-risk-of-breast-cancer
#18
Tomasz Huzarski, Barbara Górecka-Szyld, Jowita Huzarska, Grażyna Psut-Muszyńska, Grażyna Wilk, Robert Sibilski, Cezary Cybulski, Beata Kozak-Klonowska, Monika Siołek, Ewa Kilar, Dorota Czudowska, Hanna Janiszewska, Dariusz Godlewski, Andrzej Mackiewicz, Joanna Jarkiewicz-Tretyn, Jadwiga Szabo-Moskal, Jacek Gronwald, Jan Lubiński, Steven A Narod
BACKGROUND: The addition of MRI to mammography and ultrasound for breast cancer screening has been shown to improve screening sensitivity for high risk women, but there is little data to date for women at average or intermediate risk. METHODS: Two thousand nine hundred and ninety-five women, aged 40 to 65 years with no previous history of breast cancer were enrolled in a screening program, which consisted of two rounds of MRI, ultrasound and mammography, one year apart...
2017: Hereditary Cancer in Clinical Practice
https://www.readbyqxmd.com/read/28256441/supine-breast-mri-using-respiratory-triggering
#19
Natasja N Y Janssen, Leon C Ter Beek, Claudette E Loo, Gonneke Winter-Warnars, Charlotte A H Lange, Marjolein van Loveren, Tanja Alderliesten, Jan-Jakob Sonke, Jasper Nijkamp
RATIONALE AND OBJECTIVES: This study aims to evaluate if navigator-echo respiratory-triggered magnetic resonance acquisition can acquire supine high-quality breast magnetic resonance imaging (MRI). MATERIALS AND METHODS: Supine respiratory-triggered magnetic resonance imaging (Trig-MRI) was compared to supine non-Trig-MRI to evaluate breathing-induced motion artifacts (group 1), and to conventional prone non-Trig-MRI (group 2, 16-channel breast coil), all at 3T...
February 27, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28245733/targeted-fascicular-biopsy-of-the-brachial-plexus-rationale-and-operative-technique
#20
Pierre Laumonerie, Stepan Capek, Kimberly K Amrami, P James B Dyck, Robert J Spinner
OBJECTIVE Nerve biopsy is useful in the management of neuromuscular disorders and is commonly performed in distal, noncritical cutaneous nerves. In general, these procedures are diagnostic in only 20%-50%. In selected cases in which preoperative evaluation points toward a more localized process, targeted biopsy would likely improve diagnostic yield. The authors report their experience with targeted fascicular biopsy of the brachial plexus and provide a description of the operative technique. METHODS All cases of targeted biopsy of the brachial plexus biopsy performed between 2003 and 2015 were reviewed...
March 2017: Neurosurgical Focus
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