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https://www.readbyqxmd.com/read/28333841/audit-of-ca125-follow-up-after-first-line-therapy-for-ovarian-cancer
#1
Daniel Krell, Fran Said Battistino, Sarah Benafif, Lochani Ganegoda, Marcia Hall, Gordon J S Rustin
AIMS: The Medical Research Council OVO5/EORTC 55955 trial showed that patients in remission after first-line therapy for ovarian cancer did not benefit from routine measurement of CA125 during follow-up. Since the presentation of these results, we have counseled patients about the options for follow-up and provided them with an information leaflet about the trial results and the symptoms that should prompt an early appointment and CA125 measurement. We present an audit of practice after the presentation of those results...
March 23, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28332223/change-management-in-an-environment-of-ongoing-primary-health-care-system-reform-a-case-study-of-australian-primary-health-care-services
#2
Sara Javanparast, Janny Maddern, Fran Baum, Toby Freeman, Angela Lawless, Ronald Labonté, David Sanders
INTRODUCTION/BACKGROUND: Globally, health reforms continue to be high on the health policy agenda to respond to the increasing health care costs and managing the emerging complex health conditions. Many countries have emphasised PHC to prevent high cost of hospital care and improve population health and equity. The existing tension in PHC philosophies and complexity of PHC setting make the implementation and management of these changes more difficult. This paper presents an Australian case study of PHC restructuring and how these changes have been managed from the viewpoint of practitioners and middle managers...
March 22, 2017: International Journal of Health Planning and Management
https://www.readbyqxmd.com/read/28332007/rethinking-critical-reflection-on-care-late-modern-uncertainty-and-the-implications-for-care-ethics
#3
Frans Vosman, Alistair Niemeijer
Care ethics as initiated by Gilligan, Held, Tronto and others (in the nineteen eighties and nineties) has from its onset been critical towards ethical concepts established in modernity, like 'autonomy', alternatively proposing to think from within relationships and to pay attention to power. In this article the question is raised whether renewal in this same critical vein is necessary and possible as late modern circumstances require rethinking the care ethical inquiry. Two late modern realities that invite to rethink care ethics are complexity and precariousness...
March 22, 2017: Medicine, Health Care, and Philosophy
https://www.readbyqxmd.com/read/28331380/classical-conditioning-for-preserving-the-effects-of-short-melatonin-treatment-in-children-with-delayed-sleep-a-pilot-study
#4
Annette van Maanen, Anne Marie Meijer, Marcel G Smits, Frans J Oort
Melatonin treatment is effective in treating sleep onset problems in children with delayed melatonin onset, but effects usually disappear when treatment is discontinued. In this pilot study, we investigated whether classical conditioning might help in preserving treatment effects of melatonin in children with sleep onset problems, with and without comorbid attention deficit hyperactivity disorder (ADHD) or autism. After a baseline week, 16 children (mean age: 9.92 years, 31% ADHD/autism) received melatonin treatment for 3 weeks and then gradually discontinued the treatment...
2017: Nature and Science of Sleep
https://www.readbyqxmd.com/read/28330545/-treatment-of-chronic-diseases-in-patients-with-dementia
#5
Hanne Pedersen, Kristian Skikkild Klinkby, Frans Borch Waldorff
Comorbidity is common in patients with dementia, and due to the nature of the dementia disease, patients with dementia have special challenges in relation to comorbidity. This article is about dementia and heart failure, chronic obstructive pulmonary disease, urinary incontinence, falls, polypharmacy and chronic pain. Ongoing goal setting is important, and advance care planning is recommended. In general, comorbidity must be carefully and holistic assessed and managed according to each patient's general status of health and stage of dementia...
March 20, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28330538/brobygning-mellem-patienterne-og-sundhedsv%C3%A3-senet-vil-forbedre-behandlingen-af-patienter-med-demens
#6
EDITORIAL
Frans Boch Waldorff
No abstract text is available yet for this article.
March 20, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28329235/improving-public-health-by-improving-clinical-trial-guidelines-and-their-application
#7
Martin J Landray, Jeroen J Bax, Laurence Alliot, Marc Buyse, Adam Cohen, Rory Collins, Gerhard Hindricks, Stefan K James, Sile Lane, Aldo P Maggioni, Ann Meeker-O'Connell, Gunnar Olsson, Stuart J Pocock, Michael Rawlins, Jonathan Sellors, Kaori Shinagawa, Karin R Sipido, Liam Smeeth, Richard Stephens, Murray W Stewart, Wendy Gattis Stough, Fergus Sweeney, Frans Van de Werf, Kerrie Woods, Barbara Casadei
Evidence generated from randomized controlled trials forms the foundation of cardiovascular therapeutics and has led to the adoption of numerous drugs and devices that prolong survival and reduce morbidity, as well as the avoidance of interventions that have been shown to be ineffective or even unsafe. Many aspects of cardiovascular research have evolved considerably since the first randomized trials in cardiology were conducted. In order to be large enough to provide reliable evidence about effects on major outcomes, cardiovascular trials may now involve thousands of patients recruited from hundreds of clinical sites in many different countries...
March 8, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28329166/outcome-in-middle-aged-individuals-with-anomalous-origin-of-the-coronary-artery-from-the-opposite-sinus-a-matched-cohort-study
#8
Christoph Gräni, Dominik C Benz, Dominik A Steffen, Olivier F Clerc, Christian Schmied, Mathias Possner, Jan Vontobel, Fran Mikulicic, Cathérine Gebhard, Aju P Pazhenkottil, Oliver Gaemperli, Shelley Hurwitz, Philipp A Kaufmann, Ronny R Buechel
Aims: Anomalous origin of a coronary artery from the opposite sinus (ACAOS) has been associated with adverse cardiac events in the young. It remains unknown whether this holds true for middle-aged patients with uncorrected ACAOS as well. We assessed the outcome in middle-aged patients with newly diagnosed ACAOS by coronary computed tomography angiography (CCTA) compared with a matched cohort. Methods and results: We retrospectively identified 68 consecutive patients with ACAOS documented by CCTA...
March 16, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28326792/-i-was-just-so-different-the-experiences-of-women-diagnosed-with-an-autism-spectrum-disorder-in-adulthood-in-relation-to-gender-and-social-relationships
#9
Lucie Kanfiszer, Fran Davies, Suzanne Collins
Existing literature exploring autism spectrum disorders within female populations predominantly utilises quantitative methodology. A limited number of small-scale, qualitative studies have explored the experiences of adolescent girls with autism spectrum disorder, but adult women have remained largely unheard. This study aims to broaden the stories told within autobiographical literature and empower those within the wider community of women with autism spectrum disorder. In doing so, it seeks to extend existing conceptualisations of experience to include socially and culturally located factors...
March 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/28322759/validation-and-refinement-of-prediction-models-to-estimate-exercise-capacity-in-cancer-survivors-using-the-steep-ramp-test
#10
Martijn M Stuiver, Caroline S Kampshoff, Saskia Persoon, Wim Groen, Willem van Mechelen, Mai Jm Chinapaw, Johannes Brug, Frans Nollet, Marie-José Kersten, Goof Schep, Laurien M Buffart
OBJECTIVE: To further test the validity and clinical usefulness of the Steep Ramp Test (SRT) for estimating exercise tolerance in cancer survivors, by external validation and extension of previously published prediction models for VO2peak and Wpeak. DESIGN: Cross-sectional study. SETTING: Multicenter. PARTICIPANTS: Cardiopulmonary exercise tests (CPET) and SRT data from cancer survivors (n=283) in two randomized exercise trials...
March 18, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28321334/the-interpretation-of-cholesterol-balance-derived-synthesis-data-and-surrogate-noncholesterol-plasma-markers-for-cholesterol-synthesis-under-lipid-lowering-therapies
#11
REVIEW
Frans Stellaard, Dieter Lütjohann
The cholesterol balance procedure allows the calculation of cholesterol synthesis based on the assumption that loss of endogenous cholesterol via fecal excretion and bile acid synthesis is compensated by de novo synthesis. Under ezetimibe therapy hepatic cholesterol is diminished which can be compensated by hepatic de novo synthesis and hepatic extraction of plasma cholesterol. The plasma lathosterol concentration corrected for total cholesterol concentration (R_Lath) as a marker of de novo cholesterol synthesis is increased during ezetimibe treatment but unchanged under treatment with ezetimibe and simvastatin...
2017: Cholesterol
https://www.readbyqxmd.com/read/28319003/insulin-resistance-and-cognitive-performance-in-type-2-diabetes-the-maastricht-study
#12
Stefan L C Geijselaers, Simone J S Sep, Miranda T Schram, Martin P J van Boxtel, Ronald M A Henry, Frans R J Verhey, Abraham A Kroon, Nicolaas C Schaper, Pieter C Dagnelie, Carla J H van der Kallen, Coen D A Stehouwer, Geert Jan Biessels
AIMS: Type 2 diabetes, hyperinsulinemia, and insulin resistance are associated with cognitive impairment. Experimental studies indicate that insulin signaling in the brain is related to cognitive performance. Here we evaluated whether insulin-related variables contribute to the variance in cognitive performance among individuals with type 2 diabetes. METHODS: A total of 806 individuals with type 2 diabetes (mean age 62±8years, HbA1c 6.9±1.1%) completed a neuropsychological test battery...
February 12, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28317486/abnormal-clock-gene-expression-and-locomotor-activity-rhythms-in-two-month-old-female-appswe-ps1de9-mice
#13
Olaide Oyegbami, Hilary M Collins, Marie C Pardon, Fran Jp Ebling, David M Heery, Paula M Moran
In addition to cognitive decline, Alzheimer's disease (AD) is also characterized by agitation and disruptions in activity and sleep. These symptoms typically occur in the evening or at night and have been referred to as 'sundowning'. These symptoms are especially difficult for carers and there are no specific drug treatments. There is increasing evidence that these symptoms reflect an underlying pathology of circadian rhythm generation and transmission. We investigated whether a transgenic mouse model relevant to AD (APPswe/PS1dE9) exhibits circadian alterations in locomotor activity and expression of clock genes involved in the regulation of the circadian cycle...
March 17, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28314946/late-onset-islet-autoimmunity-in-childhood-the-diabetes-autoimmunity-study-in-the-young-daisy
#14
Brigitte I Frohnert, Lisa Ide, Fran Dong, Anna E Barón, Andrea K Steck, Jill M Norris, Marian J Rewers
AIMS/HYPOTHESIS: We sought to assess the frequency, determinants and prognosis for future diabetes in individuals with islet autoimmunity and whether these factors differ depending on the age of onset of islet autoimmunity. METHODS: A prospective cohort (n = 2547) of children from the general population who had a high-risk HLA genotype and children who had a first-degree relative with type 1 diabetes were followed for up to 21 years. Those with the persistent presence of one or more islet autoantibodies were categorised as early-onset (<8 years of age, n = 143, median 3...
March 17, 2017: Diabetologia
https://www.readbyqxmd.com/read/28303095/an-explanation-for-the-role-of-the-amygdala-in-aesthetic-judgments
#15
Richard H A H Jacobs, Frans W Cornelissen
It has been proposed that the top-down guidance of feature-based attention is the basis for the involvement of the amygdala in various tasks requiring emotional decision-making (Jacobs et al., 2012a). Aesthetic judgments are correlated with particular visual features and can be considered emotional in nature (Jacobs et al., 2016). Moreover, we have previously shown that various aesthetic judgments result in observers preferentially attending to different visual features (Jacobs et al., 2010). Here, we argue that-together-this explains why the amygdalae become active during aesthetic judgments of visual materials...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28302263/lower-limb-amputation-in-germany
#16
Knut Kröger, Christian Berg, Frans Santosa, Nasser Malyar, Holger Reinecke
BACKGROUND: Declining amputation rates have been reported in multiple countries in recent years. It is not yet known whether amputation rates have declined in Germany as well. METHODS: On the basis of DRG (diagnosis-related group) data, we received a list from the German Federal Statistical Office of all major and minor amputations documented in German hospitals from 2005 to 2014. Changes over this period were studied with linear regression. RESULTS: The absolute number of amputations per year in Germany rose slightly from 55 689 in 2005 to 57 637 (+3...
February 24, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28301864/functional-recovery-in-patients-with-and-without-intensive-care-unit-acquired-weakness
#17
Daniela Susanne Dettling-Ihnenfeldt, Luuk Wieske, Janneke Horn, Frans Nollet, Marike van der Schaaf
OBJECTIVE: The aim of this work was to compare the patient-reported functional health status with regard to physical, psychological, and social functioning of intensive care unit (ICU) survivors with and without ICU-acquired weakness (ICU-AW). DESIGN: Single-center prospective study in ICU patients who were mechanically ventilated for more than 2 days and who survived to ICU discharge. Functional health status was assessed at 3, 6, and 12 months after ICU discharge, using the Sickness Impact Profile 68 (SIP68)...
April 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28296651/the-predictive-validity-of-a-text-based-situational-judgment-test-in-undergraduate-medical-and-dental-school-admissions
#18
Fiona Patterson, Fran Cousans, Helena Edwards, Anna Rosselli, Sandra Nicholson, Barry Wright
PROBLEM: Situational judgment tests (SJTs) can be used to assess the nonacademic attributes necessary for medical and dental trainees to become successful practitioners. Evidence for SJTs' predictive validity, however, relates predominantly to selection in postgraduate settings or using video-based SJTs at the undergraduate level; it may not be directly transferable to text-based SJTs in undergraduate medical and dental school selection. This preliminary study aimed to address these gaps by assessing the validity of the UK Clinical Aptitude Test (UKCAT) text-based SJT...
March 14, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28296253/rituximab-in-the-treatment-of-sj%C3%A3-gren-s-syndrome-is-it-the-wrong-drug
#19
EDITORIAL
Hendrika Bootsma, Frans G M Kroese, Arjan Vissink
No abstract text is available yet for this article.
March 10, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28294220/the-microfluidic-nebulator-production-of-sub-micrometer-sized-airborne-drops
#20
Esther Amstad, Frans Spaepen, Michael P Brenner, David A Weitz
Many powders employed in the food and pharmaceutical industries are produced through spray drying because it is a cost efficient process that offers control over the particle size. However, most commercially available spray-driers cannot produce drops with diameters below 1 μm, limiting the size of spray-dried particles to values above 300 nm. We recently developed a microfluidic spray-drier that can form much smaller drops than commercially available spray-driers. This is achieved through a two-step process: first, the microfluidic spray-drier operates in the dripping regime to form 100 μm diameter primary drops in air and, second, subjects them to high shear stresses due to supersonic flow of air to break them into many much smaller secondary drops...
March 15, 2017: Lab on a Chip
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