keyword
MENU ▼
Read by QxMD icon Read
search

fran

keyword
https://www.readbyqxmd.com/read/29786516/immediate-or-deferred-adjustment-of-drug-regimens-in-multidose-drug-dispensing-systems
#1
Bram J Mertens, Henk-Frans Kwint, Rob J van Marum, Marcel L Bouvy
BACKGROUND: Multidose drug dispensing (MDD) is used to help patients take their medicines appropriately. Little is known about drug regimen changes within these MDD systems and how they are effectuated by the community pharmacist. Manual immediate adjustments of the MDD system could introduce dispensing errors. MDD guidelines therefore recommend to effectuate drug regimen changes at the start of a new MDD system. OBJECTIVE: The aim of this study was to investigate the frequency, type, procedure followed, immediate necessity, and time taken to make MDD adjustments...
May 18, 2018: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29784512/epidemiology-and-etiology-of-invasive-bacterial-infection-in-infants-%C3%A2-60-days-old-treated-in-emergency-departments
#2
Christopher Woll, Mark I Neuman, Christopher M Pruitt, Marie E Wang, Eugene D Shapiro, Samir S Shah, Russell J McCulloh, Lise E Nigrovic, Sanyukta Desai, Adrienne G DePorre, Rianna C Leazer, Richard D Marble, Fran Balamuth, Elana A Feldman, Laura F Sartori, Whitney L Browning, Paul L Aronson
OBJECTIVES: To help guide empiric treatment of infants ≤60 days old with suspected invasive bacterial infection by describing pathogens and their antimicrobial susceptibilities. STUDY DESIGN: Cross-sectional study of infants ≤60 days old with invasive bacterial infection (bacteremia and/or bacterial meningitis) evaluated in the emergency departments of 11 children's hospitals between July 1, 2011 and June 30, 2016. Each site's microbiology laboratory database or electronic medical record system was queried to identify infants from whom a bacterial pathogen was isolated from either blood or cerebrospinal fluid...
May 18, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29777850/a-novel-cardiovascular-prosthesis-made-from-woven-ultra-high-molecular-weight-polyethylene-fibers-proof-of-concept-in-a-sheep-model
#3
Amir Basir, Mylène Loncq de Jong, Aryan Vink, Gerard Pasterkamp, Paul Gründeman, Frans Moll, Joost van Herwaarden
BACKGROUND: A patch, made of woven ultra-high molecular weight polyethylene (UHMWPE) fibers is thin, strong, and flexible, and may be attractive for use in cardiovascular prostheses. This study assessed the hemocompatibility of this patch in a sheep model. METHODS: The UHMWPE patches were sutured in the right carotid artery and jugular vein in 12 adult sheep, and in the same animal, expanded polytetrafluoroethylene (ePTFE) patches were sutured as control patches in the left carotid artery and jugular vein...
May 16, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29776063/electrostatic-stiffening-and-induced-persistence-length-for-coassembled-molecular-bottlebrushes
#4
Ingeborg M Storm, Martien A Cohen Stuart, Renko de Vries, Frans A M Leermakers
A self-consistent field analysis for tunable contributions to the persistence length of isolated semiflexible polymer chains including electrostatically driven coassembled deoxyribonucleic acid (DNA) bottlebrushes is presented. When a chain is charged, i.e., for polyelectrolytes, there is, in addition to an intrinsic rigidity, an electrostatic stiffening effect, because the electric double layer resists bending. For molecular bottlebrushes, there is an induced contribution due to the grafts. We explore cases beyond the classical phantom main-chain approximation and elaborate molecularly more realistic models where the backbone has a finite volume, which is necessary for treating coassembled bottlebrushes...
March 2018: Physical Review. E
https://www.readbyqxmd.com/read/29775206/prospective-determination-of-aspirin-sensitivity-in-patients-resistant-to-low-dose-aspirin-a-proof-of-concept-study
#5
Erica S Westphal, Michelle Rainka, Michelle Amsler, Traci Aladeen, Caitlin Wisniewski, Vernice Bates, Fran M Gengo
This study tested the capability of an assay to predict aspirin response and reduce ischemic events, and healthcare costs, and delays to optimal treatment. Patients who needed aspirin in the course of normal medical care were included. Patients were excluded if they had disorders affecting platelet function, alcohol use within 24 hours of a test, or NSAID use. Dose escalation of chewable aspirin from 81 mg, to 162 mg, to 325 mg daily occurred based on the results of whole blood impedance aggregation testing to the agonists, collagen (1ug/mL, 5 ug/mL) and arachidonate (0...
May 18, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29775202/the-development-of-an-in-vitro-assay-for-the-prospective-determination-of-aspirin-sensitivity
#6
Erica S Westphal, Caitlin Wisniewski, Michelle Rainka, Nicholas M Smith, Vernice Bates, Fran M Gengo
Aspirin remains the standard for stroke prophylaxis. However, as many as 20%-25% of patients may fail to show a full response to aspirin. Ideally, patients who are resistant to aspirin could be identified, then receive an increased dose of aspirin or be changed to an alternative therapy more efficiently. We have developed an in vitro assay that may make this possible. Healthy volunteers (n = 13) between 18 and 50 years of age were tested for both ex vivo and in vivo responses to aspirin. Dimethyl sulfoxide (DMSO) was selected as the solvent for aspirin in the assay...
May 18, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29771311/pathobiology-of-cardiac-dyssynchrony-and-resynchronization-therapy
#7
Uyên Châu Nguyên, Nienke J Verzaal, Frans A van Nieuwenhoven, Kevin Vernooy, Frits W Prinzen
Synchronous ventricular electrical activation is a prerequisite for adequate left ventricular (LV) systolic function. Conduction abnormalities such as left bundle branch block, and ventricular pacing lead to a dyssynchronous electrical activation sequence, which may have deleterious consequences. The present review attempts to connect the various processes involved in the development of 'dyssynchronopathy', and its correction by cardiac resynchronization therapy (CRT). Abnormal electrical impulse conduction leads to abnormal contraction, characterized by regional differences in timing as well as shortening patterns and amount of external work performed...
May 15, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29769073/measuring-bothersome-menopausal-symptoms-development-and-validation-of-the-menoscores-questionnaire
#8
Kamma Sundgaard Lund, Volkert Dirk Siersma, Karl Bang Christensen, Frans Boch Waldorff, John Brodersen
BACKGROUND: The experience of menopausal symptoms is common and an adequate patient-reported outcome measure is crucial in studies where women are treated for these symptoms. The aims of this study were to identify a patient-reported outcome measure for bothersome menopausal symptoms and, in the absence of an adequate tool, to develop a new measure with high content validity, and to validate it using modern psychometric methods. METHODS: The literature was reviewed for existing questionnaires and checklists for bothersome menopausal symptoms...
May 16, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29768181/description-of-hot-debriefings-after-in-hospital-cardiac-arrests-in-an-international-pediatric-quality-improvement-collaborative
#9
Todd Sweberg, Anita I Sen, Paul C Mullan, Adam Cheng, Lynda Knight, Jimena Del Castillo, Takanari Ikeyama, Roopa Seshadri, Mary Fran Hazinski, Tia Raymond, Dana E Niles, Vinay Nadkarni, Heather Wolfe
BACKGROUND: The American Heart Association recommends debriefing after attempted resuscitation from in-hospital cardiac arrest (IHCA) to improve resuscitation quality and outcomes. This is the first published study detailing the utilization, process and content of hot debriefings after pediatric IHCA. METHODS: Using prospective data from the Pediatric Resuscitation Quality Collaborative (pediRES-Q), we analyzed data from 227 arrests occurring between February 1, 2016, and August 31, 2017...
May 13, 2018: Resuscitation
https://www.readbyqxmd.com/read/29756222/disease-associated-changes-in-drug-transporters-may-impact-the-pharmacokinetics-and-or-toxicity-of-drugs-a-white-paper-from-the-international-transporter-consortium
#10
REVIEW
Raymond Evers, Micheline Piquette-Miller, Joseph W Polli, Frans G M Russel, Jason A Sprowl, Kimio Tohyama, Joseph A Ware, Saskia N de Wildt, Wen Xie, Kim L R Brouwer
No abstract text is available yet for this article.
May 14, 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29752720/prognostic-roles-for-il-2-producing-and-cd69-t-cell-subsets-in-colorectal-cancer-patients
#11
Edward S Taylor, John L McCall, Shirley Shen, Adam Girardin, Fran M Munro, Michael A Black, Kirsten A Ward-Hartstonge, Roslyn A Kemp
Tumor infiltrating T cells are a predictor of patient outcome in patients with colorectal cancer (CRC). However, many T cell populations have been associated with both poor and positive patient prognoses, indicating a need to further understand the role of different T cell subsets in CRC. In this study, the T cell infiltrate from the tumor and non-tumor bowel (NTB) was examined in 95 CRC patients using flow cytometry and associations with cancer stage and disease recurrence made. Our findings showed that IFN-γ-producing T cells were associated with positive patient outcomes, and CD69+ T cells were associated with disease recurrence...
May 11, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29747915/prognostic-and-practical-validation-of-current-definitions-of-myocardial-infarction-associated-with-percutaneous-coronary-intervention
#12
Pierluigi Tricoci, L Kristin Newby, Robert M Clare, Sergio Leonardi, C Michael Gibson, Robert P Giugliano, Paul W Armstrong, Frans Van de Werf, Gilles Montalescot, David J Moliterno, Claes Held, Philip E Aylward, Lars Wallentin, Robert A Harrington, Eugene Braunwald, Kenneth W Mahaffey, Harvey D White
OBJECTIVES: In 13,038 patients with non-ST-segment elevation acute coronary syndrome undergoing index percutaneous coronary intervention (PCI) in the EARLY ACS (Early Glycoprotein IIb/IIIa Inhibition in Non-ST-Segment Elevation Acute Coronary Syndrome) and TRACER (Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome) trials, the relationship between PCI-related myocardial infarction (MI) and 1-year mortality was assessed. BACKGROUND: The definition of PCI-related MI is controversial...
May 14, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29746602/correction-changes-in-aortic-pulse-wave-velocity-of-four-thoracic-aortic-stent-grafts-in-an-ex-vivo-porcine-model
#13
Hector W L de Beaufort, Margherita Coda, Michele Conti, Theodorus M J van Bakel, Foeke J H Nauta, Ettore Lanzarone, Frans L Moll, Joost A van Herwaarden, Ferdinando Auricchio, Santi Trimarchi
[This corrects the article DOI: 10.1371/journal.pone.0186080.].
2018: PloS One
https://www.readbyqxmd.com/read/29740269/comparison-of-multi-tensor-diffusion-models-performance-for-white-matter-integrity-estimation-in-chronic-stroke
#14
Olena G Filatova, Lucas J van Vliet, Alfred C Schouten, Gert Kwakkel, Frans C T van der Helm, Frans M Vos
Better insight into white matter (WM) alterations after stroke onset could help to understand the underlying recovery mechanisms and improve future interventions. MR diffusion imaging enables to assess such changes. Our goal was to investigate the relation of WM diffusion characteristics derived from diffusion models of increasing complexity with the motor function of the upper limb. Moreover, we aimed to evaluate the variation of such characteristics across different WM structures of chronic stroke patients in comparison to healthy subjects...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29734144/long-term-neurodevelopmental-and-respiratory-outcome-after-intrauterine-therapy-for-fetal-thoracic-abnormalities
#15
Ruben S G M Witlox, Enrico Lopriore, Monique Rijken, Frans J C M Klumper, Dick Oepkes, Jeanine M M van Klink
INTRODUCTION: The aim of this study is to evaluate long-term neurodevelopmental and respiratory outcome after fetal therapy for fetal pleural effusion, congenital cystic adenomatoid malformation, and bronchopulmonary sequestration. METHODS: Children ≥18 months of age underwent an assessment of neurologic, motor, and cognitive development. Medical records were reviewed to determine respiratory outcome. Behavioral outcome was assessed using the Child Behavioral Checklist...
May 7, 2018: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29733675/implications-of-attachment-theory-and-neuroscience-for-the-psychotherapeutic-treatment-of-obesity-and-overeating
#16
Fran Weiss
This article examines psychological sequelae underlying dysregulated eating in the overweight and obese patient and proposes a psychotherapy approach informed by classical and modern attachment theory, developmental trauma, and neuroscience to address these structural deficits.
May 7, 2018: American Journal of Psychotherapy
https://www.readbyqxmd.com/read/29723923/a-humidifier-in-the-invasive-mode-during-non-invasive-respiratory-support-could-increase-condensation-and-thereby-impair-airway-patency
#17
Rutger C Flink, Anton H van Kaam, Frans H de Jongh
AIM: Humidifying non-invasively ventilated preterm infants is critical to prevent dehydration of respiratory mucosa, but over humidification can result in impaired airway patency and lung mechanics. This neonatal bench study investigated the humidity delivered using invasive and non-invasive humidification modes during nasal continuous positive airway pressure. METHODS: The study was conducted at the neonatal intensive care unit of Emma Children's Hospital, the Netherlands, in March 2014...
May 3, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29722656/patterns-of-involved-field-radiation-therapy-protocol-deviations-in-pediatric-versus-adolescent-and-young-adults-with-hodgkin-lymphoma-a-report-from-the-children-s-oncology-group-ahod0031
#18
Aaron Parzuchowski, Rizvan Bush, Qinglin Pei, Debra L Friedman, Thomas J FitzGerald, Suzanne L Wolden, Kavita V Dharmarajan, Louis S Constine, Fran Laurie, Sandy K Kessel, Burton Appel, Karen Fernandez, Angela Punnett, Cindy L Schwartz, Jacob Cox, Stephanie A Terezakis
PURPOSE: The presented protocol for pediatric intermediate-risk Hodgkin lymphoma evaluated the use of a dose-intensive chemotherapy regimen (ABVE-PC [doxorubicin, bleomycin, vincristine, etoposide, cyclophosphamide, prednisone]) with response-based therapy augmentation (addition of DECA [dexamethasone, etoposide, cisplatin, cytarabine]) or therapy reduction (elimination of radiation). METHODS AND MATERIALS: A central review of the radiation therapy data for quality assurance was performed, and the association between radiation protocol deviation (RPD) and relapse was assessed in the pediatric group (age <15 years) and adolescent and young adult (AYA) group (age ≥15-21 years)...
April 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29721931/antisense-oligonucleotide-based-splice-correction-of-a-deep-intronic-mutation-in-chm-underlying-choroideremia
#19
Alejandro Garanto, Saskia D van der Velde-Visser, Frans P M Cremers, Rob W J Collin
Choroideremia is a progressive genetic eye disorder caused by mutations in the CHM gene that encodes the Rab escort protein-1 (REP-1). One of the many CHM mutations described so far is a deep-intronic variant, c.315-4587T>A, that creates a novel splice acceptor site resulting in the insertion of a 98-bp pseudoexon in the CHM transcript. Antisense oligonucleotides (AONs) are a potential therapeutic tool for correcting splice defects, as they have the properties to bind to the pre-mRNA and redirect the splicing process...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29719289/the-effect-of-minimally-invasive-surfactant-therapy-on-diaphragmatic-activity
#20
Cornelia G de Waal, Gerard J Hutten, Frans H de Jongh, Anton H van Kaam
BACKGROUND: Minimally invasive surfactant therapy (MIST) is increasingly used to treat preterm infants with respiratory distress syndrome (RDS). However, the effect of MIST on breathing effort is poorly studied. OBJECTIVES: To describe the effect of MIST on neural breathing effort assessed with transcutaneous electromyography of the diaphragm (dEMG) in preterm infants with RDS. METHODS: Preterm infants with a gestational age < 37 weeks treated with MIST for RDS were included...
May 2, 2018: Neonatology
keyword
keyword
70492
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"