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https://www.readbyqxmd.com/read/28650316/the-na-ca-2-k-exchanger-nckx4-is-required-for-efficient-cone-mediated-vision
#1
Frans Vinberg, Tian Wang, Alicia De Maria, Haiqing Zhao, Steven Bassnett, Jeannie Chen, Vladimir J Kefalov
Calcium (Ca(2+)) plays an important role in the function and health of neurons. In vertebrate cone photoreceptors, Ca(2+) controls photoresponse sensitivity, kinetics, and light adaptation. Despite the critical role of Ca(2+) in supporting the function and survival of cones, the mechanism for its extrusion from cone outer segments is not well understood. Here, we show that the Na(+)/Ca(2+), K(+) exchanger NCKX4 is expressed in zebrafish, mouse, and primate cones. Functional analysis of NCKX4-deficient mouse cones revealed that this exchanger is essential for the wide operating range and high temporal resolution of cone-mediated vision...
June 26, 2017: ELife
https://www.readbyqxmd.com/read/28647641/impact-of-left-subclavian-artery-revascularization-prior-to-thoracic-endovascular-aortic-repair-on-post-operative-cerebrovascular-hemodynamics
#2
Arnoud V Kamman, Jonathan L Eliason, David M Williams, Bo Yang, Frans L Moll, Santi Trimarchi, Kim A Eagle, Himanshu J Patel
OBJECTIVES: The impact of left subclavian artery (LSA) revascularization prior to thoracic endovascular aortic repair (TEVAR) on cerebrovascular flow is not well described. We studied bilateral vertebral and carotid artery flow characteristics before and after TEVAR, to evaluate the hemodynamic effects of LSA revascularization. METHODS: Seventy-four patients with mixed etiologies (mean age 70.9±10.5 years) underwent LSA revascularization and TEVAR (2006-2016) and had available pre- and post-operative carotid Duplex study available...
June 21, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28647166/clinical-development-of-a-recombinant-ebola-vaccine-in-the-midst-of-an-unprecedented-epidemic
#3
Beth-Ann G Coller, Jeffrey Blue, Rituparna Das, Sheri Dubey, Lynn Finelli, Swati Gupta, Frans Helmond, Rebecca J Grant-Klein, Kenneth Liu, Jakub Simon, Sean Troth, Susan VanRheenen, Julie Waterbury, Ashley Wivel, Jayanthi Wolf, D Gray Heppner, Tracy Kemp, Rick Nichols, Thomas P Monath
The 2014-2016 Ebola outbreak caused over 28,000 cases and 11,000 deaths. Merck & Co. Inc., Kenilworth, NJ USA and NewLink Genetics are working with private and public partners to develop and license an Ebola vaccine that was evaluated extensively during the outbreak. The vaccine referred to as V920 is a recombinant vesicular stomatitis virus (rVSV) in which the VSV-G envelope glycoprotein (GP) is completely replaced by the Zaire ebolavirus GP (rVSVΔG-ZEBOV-GP). Eight Phase I and four Phase II/III clinical trials enrolling approximately 17,000 subjects were conducted in parallel to the outbreak to assess the safety, immunogenicity, and/or efficacy of V920...
June 21, 2017: Vaccine
https://www.readbyqxmd.com/read/28646082/subcutaneous-magnesium-in-the-advanced-cancer-setting
#4
Stephen J Fenning, Steinunn R Boyce, Paul Wilson, Fran Stretton
Hypomagnesaemia can arise from a variety of causes but is particularly prevalent in cancer populations. This case report describes a patient with recurrent symptomatic hypomagnesaemia, on the background of advanced ovarian cancer and a high-output ileostomy, who was successfully managed on a daily continuous subcutaneous infusion of magnesium via a syringe pump. There is limited published information on the subcutaneous administration of magnesium and, to our knowledge, this is the first case to report its routine delivery over 24 hours in a syringe pump...
June 23, 2017: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/28643900/exploring-perspectives-of-young-onset-dementia-caregivers-with-high-versus-low-unmet-needs
#5
Joany K Millenaar, Christian Bakker, Deliane van Vliet, Raymond T C M Koopmans, Alexander Kurz, Frans R J Verhey, Marjolein E de Vugt
BACKGROUND: This study is part of the Research to Assess Policies and Strategies for Dementia in the Young project. Information about specific needs in young onset dementia (YOD) will provide the basis for the development of an e-health intervention to assist caregivers in coping with YOD in several European countries. OBJECTIVE: The aim was to investigate the issues caregivers of people with YOD face. METHODS: A qualitative content analysis method was used to analyse interviews with YOD caregivers...
June 23, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28642400/human-nature
#6
Frans de Waal
No abstract text is available yet for this article.
June 23, 2017: Science
https://www.readbyqxmd.com/read/28639307/anti-d-in-a-mother-hemizygous-for-the-variant-rhd-dnb-gene-associated-with-hemolytic-disease-of-the-fetus-and-newborn
#7
Kelli M Quantock, Genghis H Lopez, Catherine A Hyland, Yew-Wah Liew, Robert L Flower, Frans J Niemann, Arthur Joyce
BACKGROUND: Individuals with the partial D phenotype when exposed to D+ red blood cells (RBCs) carrying the epitopes they lack may develop anti-D specific for the missing epitopes. DNB is the most common partial D in Caucasians and the clinical significance for anti-D in these individuals is unknown. STUDY DESIGN AND METHODS: This article describes the serologic genotyping results and clinical manifestations in two group D+ babies of a mother presenting as group O, D+ with alloanti-D...
June 21, 2017: Transfusion
https://www.readbyqxmd.com/read/28627230/relationship-between-community-hospital-versus-pre-hospital-location-of-randomisation-and-clinical-outcomes-in-st-elevation-myocardial-infarction-patients-insights-from-the-stream-study
#8
Robert C Welsh, Patrick Goldstein, Peter Sinnaeve, Miodrag C Ostojic, Yinggan Zheng, Thierry Danays, Cynthia M Westerhout, Frans Van de Werf, Paul W Armstrong
AIMS: The STREAM study randomly assigned ST-elevation myocardial infarction (STEMI) patients to receive a pharmacoinvasive versus primary percutaneous coronary intervention reperfusion strategy. We assessed whether there was an association between outcomes based on randomisation at a community hospital versus a prehospital location. METHODS/RESULTS: Community hospital patients (358/1866 (19.2%)) were compared to prehospital patients and their outcomes categorised into pharmacoinvasive according to their treatment assignment...
June 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28626990/exhaled-breath-profiles-in-the-monitoring-of-loss-of-control-and-clinical-recovery-in-asthma
#9
Paul Brinkman, Marianne A van de Pol, Marije G Gerritsen, Lieuwe D Bos, Tamara Dekker, Barbara S Smids, Anirban Sinha, Christof J Majoor, Marlous M Sneeboer, Hugo H Knobel, Teunis J Vink, Frans H de Jongh, René Lutter, Peter J Sterk, Niki Fens
BACKGROUND: Asthma is a chronic inflammatory airway disease, associated with episodes of exacerbations. Therapy with inhaled corticosteroids (ICS) targets airway inflammation, which aims to maintain and restore asthma control. Clinical features are only modestly associated with airways inflammation. Therefore, we hypothesized that exhaled volatile metabolites identify longitudinal changes between clinically stable episodes and loss of asthma control. OBJECTIVES: To determine whether exhaled volatile organic compounds (VOCs) as measured by gas-chromatography / mass-spectrometry (GC/MS) and electronic nose (eNose) technology discriminate between clinically stable and unstable episodes of asthma...
June 19, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28623346/early-onset-primary-antibody-deficiency-resembling-common-variable-immunodeficiency-challenges-the-diagnosis-of-wiedeman-steiner-and-roifman-syndromes
#10
Delfien J Bogaert, Melissa Dullaers, Hye Sun Kuehn, Bart P Leroy, Julie E Niemela, Hans De Wilde, Sarah De Schryver, Marieke De Bruyne, Frauke Coppieters, Bart N Lambrecht, Frans De Baets, Sergio D Rosenzweig, Elfride De Baere, Filomeen Haerynck
Syndromic primary immunodeficiencies are rare genetic disorders that affect both the immune system and other organ systems. More often, the immune defect is not the major clinical problem and is sometimes only recognized after a diagnosis has been made based on extra-immunological abnormalities. Here, we report two sibling pairs with syndromic primary immunodeficiencies that exceptionally presented with a phenotype resembling early-onset common variable immunodeficiency, while extra-immunological characteristics were not apparent at that time...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28623067/a-case-report-of-abnormal-fracture-healing-as-detected-with-high-resolution-peripheral-quantitative-computed-tomography
#11
Frans L Heyer, Joost J A de Jong, Rob J E M Smeets, Jacobus J Arts, Martijn Poeze, Piet P Geusens, Bert van Rietbergen, Joop P van den Bergh, Paul C Willems
No abstract text is available yet for this article.
June 13, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28622045/age-related-characteristics-of-outpatients-with-anxiety-disorders-the-leiden-routine-outcome-monitoring-study
#12
Anke Schat, Martijn S van Noorden, Therese van Amelsvoort, Erik J Giltay, Nic J A van der Wee, Marc J Noom, Robert R J M Vermeiren, Frans G Zitman
OBJECTIVE: It has been hypothesised that clinically important age-related differences between adults with anxiety disorders exist; this study aims to elucidate these differences. METHODS: We analysed data from 1950 outpatients diagnosed with DSM-IV-TR anxiety disorders treated at a Dutch hospital or affiliated mental healthcare centres. Three age-groups (young- (18-25; n = 435), mid- (26-40; n = 788) and older adult (41-65; n = 727)) were compared with regard to social demographic characteristics, diagnostic characteristics, anxiety symptom profile, general psychiatric symptom profile and generic health status, in addition, linear analyses were carried out with age as a continuous variable...
June 16, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28619423/acute-respiratory-distress-syndrome-following-alemtuzumab-therapy-for-relapsing-multiple-sclerosis
#13
Keh Yann, Fran Jackson, Nazar Sharaf, Tatiana Mihalova, Paul Talbot, David Rog, Adrian Pace
We present the case of a 54 year old woman with known relapsing-remitting multiple sclerosis who presented with acute respiratory deterioration five weeks after a first course of alemtuzumab. Imaging showed bilateral ground glass changes and extensive investigations confirmed chest infection with dual pathogens - Pneumocystis jirovecii and Cytomegalovirus. She responded to standard anti-PJP and CMV therapy and was discharged on oral prophylaxis. Opportunistic infections in the weeks immediately following alemtuzumab therapy remain an uncommon complication but one that requires clinical vigilance, careful monitoring and appropriate prophylactic therapy...
May 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28609488/comment-who-s-weakness-is-not-technical-but-due-to-lack-of-accountability
#14
David G Legge, Claudio Schuftan, Fran E Baum, Remco van de Pas, David Sanders, Lori Hanson, David McCoy, Amit Sengupta
No abstract text is available yet for this article.
February 2017: BMJ Global Health
https://www.readbyqxmd.com/read/28608451/commissioning-and-equity-in-primary-care-in-australia-views-from-primary-health-networks
#15
Julie Henderson, Sara Javanparast, Tamara MacKean, Toby Freeman, Fran Baum, Anna Ziersch
This paper reports findings from 55 stakeholder interviews undertaken in six Primary Health Networks (PHNs) in Australia as part of a study of the impact of population health planning in regional primary health organisations on service access and equity. Primary healthcare planning is currently undertaken by PHNs which were established in 2015 as commissioning organisations. This was a departure from the role of Medicare Locals, the previous regional primary health organisations which frequently provided services...
June 12, 2017: Health & Social Care in the Community
https://www.readbyqxmd.com/read/28606195/a-mismatch-between-supply-and-demand-of-social-support-in-dementia-care-a-qualitative-study-on-the-perspectives-of-spousal-caregivers-and-their-social-network-members
#16
Alieske E H Dam, Lizzy M M Boots, Martin P J van Boxtel, Frans R J Verhey, Marjolein E de Vugt
BACKGROUND: Access to social support contributes to feelings of independence and better social health. This qualitative study aims to investigate multi-informant perspectives on informal social support in dementia care networks. METHODS: Ten spousal caregivers of people with dementia (PwD) completed an ecogram, a social network card and a semi-structured interview. The ecogram aimed to trigger subjective experiences regarding social support. Subsequently, 17 network members were interviewed...
June 13, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28605497/message-from-the-iscb-2017-outstanding-contributions-to-iscb-award-given-to-fran-lewitter
#17
Christiana N Fogg, Diane E Kovats, Bonnie Berger
No abstract text is available yet for this article.
June 10, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28605402/sparse-redundancy-analysis-of-high-dimensional-genetic-and-genomic-data
#18
Attila Csala, Frans P J M Voorbraak, Aeilko H Zwinderman, Michel H Hof
Motivation: Recent technological developments have enabled the possibility of genetic and genomic integrated data analysis approaches, where multiple omics data sets from various biological levels are combined and used to describe (disease) phenotypic variations. The main goal is to explain and ultimately predict phenotypic variations by understanding their genetic basis and the interaction of the associated genetic factors. Therefore, understanding the underlying geneticmechanisms of phenotypic variations is an ever increasing research interest in biomedical sciences...
June 12, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28603078/gatekeepers-in-the-healthcare-sector-knowledge-and-bourdieu-s-concept-of-field
#19
Fran M Collyer, Karen F Willis, Sophie Lewis
Choice is an imperative for patients in the Australian healthcare system. The complexity of this healthcare 'maze', however, means that successfully navigating and making choices depends not only on the decisions of patients, but also other key players in the healthcare sector. Utilising Bourdieu's concepts of capital, habitus and field, we analyse the role of gatekeepers (i.e., those who control access to resources, services and knowledge) in shaping patients' experiences of healthcare, and producing opportunities to enable or constrain their choices...
June 3, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28599541/prosodic-exaggeration-within-infant-directed-speech-consequences-for-vowel-learnability
#20
Frans Adriaans, Daniel Swingley
Perceptual experiments with infants show that they adapt their perception of speech sounds toward the categories of the native language. How do infants learn these categories? For the most part, acoustic analyses of natural infant-directed speech have suggested that phonetic categories are not presented to learners as separable clusters of sounds in acoustic space. As a step toward explaining how infants begin to solve this problem, the current study proposes that the exaggerated prosody characteristic of infant-directed speech may highlight for infants certain speech-sound tokens that collectively form more readily identifiable categories...
May 2017: Journal of the Acoustical Society of America
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