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https://www.readbyqxmd.com/read/27912169/non-harmonicity-in-high-frequency-components-of-the-intra-operative-corticogram-to-delineate-epileptogenic-tissue-during-surgery
#1
Evelien E Geertsema, Maryse A van 't Klooster, Nicole E C van Klink, Frans S S Leijten, Peter C van Rijen, Gerhard H Visser, Stiliyan N Kalitzin, Maeike Zijlmans
OBJECTIVE: We aimed to test the potential of auto-regressive model residual modulation (ARRm), an artefact-insensitive method based on non-harmonicity of the high-frequency signal, to identify epileptogenic tissue during surgery. METHODS: Intra-operative electrocorticography (ECoG) of 54 patients with refractory focal epilepsy were recorded pre- and post-resection at 2048Hz. The ARRm was calculated in one-minute epochs in which high-frequency oscillations (HFOs; fast ripples, 250-500Hz; ripples, 80-250Hz) and spikes were marked...
November 17, 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/27908315/-life-threatening-ketoacidosis-in-a-25-year-old-woman-treated-with-sodium-glucose-cotransporter-2-inhibitor
#2
Mats Jacob Hermansson Lindberg, Frans Brandt Kristensen, Alev Yildiz
We report a case of atypical ketoacidosis in a patient treated with a sodium-glucose cotransporter- (SGLT) 2 inhibitor. The 25-year-old woman, who one year earlier had been prescribed dapagliflozin for presumed Type 2 diabetes, came to the emergency department in a state of severe ketoacidosis, pH 6.85, and a plasma glucose level of 14.3 mmol/l. She received standard treatment and recovered. We discuss the increasing evidence for atypical ketoacidosis being a serious side effect of the SGLT2 inhibitors.
November 21, 2016: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/27908305/abatacept-treatment-of-patients-with-primary-sj%C3%A3-gren-s-syndrome-results-in-a-decrease-of-germinal-centres-in-salivary-gland-tissue
#3
Erlin A Haacke, Bert van der Vegt, Petra M Meiners, Arjan Vissink, Fred K L Spijkervet, Hendrika Bootsma, Frans G M Kroese
OBJECTIVES: The aim of this study was to assess the histopathological changes in parotid gland tissue of primary Sjögren's syndrome (pSS) patients treated with abatacept. METHODS: In all 15 pSS patients included in the open-label Active Sjögren Abatacept Pilot (ASAP, 8 abatacept infusions) study parotid gland biopsies were taken before treatment and at 24 weeks of follow up. Biopsies were analysed for pSS-related histopathological features and placed in context of clini- cal responsiveness as assessed with EULAR Sjögren's syndrome disease activity index (ESSDAI)...
November 12, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27907250/the-transcriptional-co-activator-bob1-is-associated-with-pathologic-b-cell-responses-in-autoimmune-tissue-inflammation
#4
Maria J Levels, Melissa N Van Tok, Tineke Cantaert, Juan D Cañete, Frans G M Kroese, Kristine Germar, Hergen Spits, Dominique L P Baeten, Nataliya G Yeremenko
OBJECTIVE: The molecular mechanisms steering abnormal B cell responses in autoimmune diseases remain poorly understood. In this study we aimed to identify molecular switches controlling pathological B cell responses in rheumatoid arthritis (RA). METHODS: Candidate molecules were identified by gene expression profiling of RA synovitis and validated by qPCR and immunohistochemistry. B cell-specific expression was confirmed by immunofluorescence, immunoblotting and flow cytometry...
December 1, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27907006/prediction-of-impending-type-1-diabetes-through-automated-dual-label-measurement-of-proinsulin-c-peptide-ratio
#5
Annelien Van Dalem, Simke Demeester, Eric V Balti, Bart Keymeulen, Pieter Gillard, Bruno Lapauw, Christophe De Block, Pascale Abrams, Eric Weber, Ilse Vermeulen, Pieter De Pauw, Daniël Pipeleers, Ilse Weets, Frans K Gorus
BACKGROUND: The hyperglycemic clamp test, the gold standard of beta cell function, predicts impending type 1 diabetes in islet autoantibody-positive individuals, but the latter may benefit from less invasive function tests such as the proinsulin:C-peptide ratio (PI:C). The present study aims to optimize precision of PI:C measurements by automating a dual-label trefoil-type time-resolved fluorescence immunoassay (TT-TRFIA), and to compare its diagnostic performance for predicting type 1 diabetes with that of clamp-derived C-peptide release...
2016: PloS One
https://www.readbyqxmd.com/read/27905056/principal-covariates-clusterwise-regression-pccr-accounting-for-multicollinearity-and-population-heterogeneity-in-hierarchically-organized-data
#6
Tom Frans Wilderjans, Eva Vande Gaer, Henk A L Kiers, Iven Van Mechelen, Eva Ceulemans
In the behavioral sciences, many research questions pertain to a regression problem in that one wants to predict a criterion on the basis of a number of predictors. Although in many cases, ordinary least squares regression will suffice, sometimes the prediction problem is more challenging, for three reasons: first, multiple highly collinear predictors can be available, making it difficult to grasp their mutual relations as well as their relations to the criterion. In that case, it may be very useful to reduce the predictors to a few summary variables, on which one regresses the criterion and which at the same time yields insight into the predictor structure...
November 30, 2016: Psychometrika
https://www.readbyqxmd.com/read/27899431/monitoring-process-water-quality-using-near-infrared-spectroscopy-and-partial-least-squares-regression-with-prediction-uncertainty-estimation
#7
Peter B Skou, Thilo A Berg, Stina D Aunsbjerg, Dorrit Thaysen, Morten A Rasmussen, Frans van den Berg
Reuse of process water in dairy ingredient production-and food processing in general-opens the possibility for sustainable water regimes. Membrane filtration processes are an attractive source of process-water recovery since the technology is already utilized in the dairy industry and its use is expected to grow considerably. At Arla Foods Ingredients (AFI), permeate from a reverse osmosis polisher filtration unit is sought to be reused as process water, replacing the intake of potable water. However, as for all dairy and food producers, the process-water quality must be monitored continuously to ensure food safety...
November 29, 2016: Applied Spectroscopy
https://www.readbyqxmd.com/read/27898640/2016-note-to-reviewers
#8
Stephen Ludwig, Gary Fleisher, Fran Klass, Zella Ludwig
No abstract text is available yet for this article.
December 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27897438/the-relationship-between-cognitive-ability-and-experiences-of-vaginal-oral-and-anal-sex-in-the-united-states
#9
Nicole Fran Kahn, Carolyn Tucker Halpern
Few studies have investigated the sexual development of populations with low cognitive abilities in the United States. This article examines the relationship between cognitive ability and various sexual experiences from adolescence (ages 12 to 18) to early adulthood (ages 28 to 34). Data were from 13,845 respondents interviewed at Waves I and IV of the National Longitudinal Study of Adolescent to Adult Health (Add Health), a probability sample of adolescents in the United States followed from adolescence to adulthood...
November 29, 2016: Journal of Sex Research
https://www.readbyqxmd.com/read/27897362/unambiguous-determination-of-protein-arginine-ionization-states-in-solution-by-nmr-spectroscopy
#10
Yuichi Yoshimura, Nur Alia Oktaviani, Kento Yonezawa, Hironari Kamikubo, Frans A A Mulder
Because arginine residues in proteins are expected to be in their protonated form almost without exception, reports demonstrating that a protein arginine residue is charge-neutral are rare and potentially controversial. Herein, we present a (13) C-detected NMR experiment for probing individual arginine residues in proteins notwithstanding the presence of chemical and conformational exchange effects. In the experiment, the (15) N(η) and (15) N(ϵ) chemical shifts of an arginine head group are correlated with that of the directly attached (13) C(ζ) ...
November 29, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27894487/2016-esc-guidelines-for-the-diagnosis-and-treatment-of-acute-and-chronic-heart-failure
#11
Piotr Ponikowski, Adriaan A Voors, Stefan D Anker, Héctor Bueno, John G F Cleland, Andrew J S Coats, Volkmar Falk, José Ramón González-Juanatey, Veli-Pekka Harjola, Ewa A Jankowska, Mariell Jessup, Cecilia Linde, Petros Nihoyannopoulos, John T Parissis, Burkert Pieske, Jillian P Riley, Giuseppe M C Rosano, Luis M Ruilope, Frank Ruschitzka, Frans H Rutten, Peter van der Meer
No abstract text is available yet for this article.
December 2016: Revista Española de Cardiología
https://www.readbyqxmd.com/read/27894205/outcomes-of-second-line-treatment-in-chronic-lymphocytic-leukemia-a-population-based-study-from-a-well-defined-geographical-region-between-2003-and-2013
#12
Anna Asklid, Maria Winqvist, Sandra Eketorp Sylvan, Agnes Mattsson, Einar Björgvinsson, Frans Søltoft, Johanna Repits, Joris Diels, Anders Österborg, Lotta Hansson
No abstract text is available yet for this article.
November 28, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27893309/acarological-risk-of-borrelia-burgdorferi-sensu-lato-infections-across-space-and-time-in-the-netherlands
#13
Willem Takken, Arnold J H van Vliet, Niels O Verhulst, Frans H H Jacobs, Fedor Gassner, Nienke Hartemink, Sara Mulder, Hein Sprong
A longitudinal investigation on tick populations and their Borrelia infections in the Netherlands was undertaken between 2006 and 2011 with the aim to assess spatial and temporal patterns of the acarological risk in forested sites across the country and to assess variations in Borrelia genospecies diversity. Ticks were collected monthly in 11 sites and nymphs were examined for Borrelia infections. Tick populations expressed strong seasonal variations, with consistent and significant differences in mean tick densities between sites...
November 28, 2016: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/27889921/chimpanzee-uses-manipulative-gaze-cues-to-conceal-and-reveal-information-to-foraging-competitor
#14
Katie Hall, Mike W Oram, Matthew W Campbell, Timothy M Eppley, Richard W Byrne, Frans B M de Waal
: Tactical deception has been widely reported in primates on a functional basis, but details of behavioral mechanisms are usually unspecified. We tested a pair of chimpanzees (Pan troglodytes) in the informed forager paradigm, in which the subordinate saw the location of hidden food and the dominant did not. We employed cross-correlations to examine temporal contingencies between chimpanzees' behavior: specifically how the direction of the subordinate's gaze and movement functioned to manipulate the dominant's searching behavior through two tactics, withholding, and misleading information...
November 27, 2016: American Journal of Primatology
https://www.readbyqxmd.com/read/27889521/azacytidine-and-mir156-promote-rooting-in-adult-but-not-in-juvenile-arabidopsis-tissues
#15
Mehdi Massoumi, Frans A Krens, Richard G F Visser, Geert-Jan M De Klerk
Poor adventitious root (AR) formation is a major obstacle in micropropagation and conventional vegetative propagation of many crops. It is affected by many endogenous and exogenous factors. With respect to endogenous factors, the phase change from juvenile to adult has a major influence on AR formation and rooting is usually much reduced or even fully inhibited in adult tissues. It has been reported that the phase change is characterized by an increase in DNA-methylation and a decrease in the expression of microRNA156 (miR156)...
November 15, 2016: Journal of Plant Physiology
https://www.readbyqxmd.com/read/27885993/arterial-pulsatility-under-phasic-left-ventricular-assist-device-support
#16
Selim Bozkurt, Sjoerd van Tuijl, Frans N van de Vosse, Marcel C M Rutten
The aim of this study is to understand whether the phasic Continuous Flow Left Ventricular Assist Device (CF-LVAD) support would increase the arterial pulsatility. A Micromed DeBakey CF-LVAD was used to apply phasic support in an ex-vivo experimental platform. CF-LVAD was operated over a cardiac cycle by phase-shifting the pulsatile pump control with respect to the heart cycle, in 0.05 s increments in each experiment. The pump flow rate was selected as the control variable and a reference model was used to operate the CF-LVAD at a pulsatile speed...
November 25, 2016: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/27885904/the-effect-of-p2y12-inhibition-on-platelet-activation-assessed-with-aggregation-and-flow-cytometry-based-assays
#17
Tesse C Leunissen, Peter Paul Wisman, Thijs C van Holten, Philip G de Groot, Suzanne J Korporaal, Arnold C Koekman, Frans L Moll, Martin Teraa, Marianne C Verhaar, Gert Jan de Borst, Rolf T Urbanus, Mark Roest
Patients on P2Y12 inhibitors may still develop thrombosis or bleeding complications. Tailored antiplatelet therapy, based on platelet reactivity testing, might reduce these complications. Several tests have been used, but failed to show a benefit of tailored antiplatelet therapy. This could be due to the narrowness of current platelet reactivity tests, which are limited to analysis of platelet aggregation after stimulation of the adenosine diphosphate (ADP)-pathway. However, the response to ADP does not necessarily reflect the effect of P2Y12 inhibition on platelet function in vivo...
November 25, 2016: Platelets
https://www.readbyqxmd.com/read/27884917/managing-barriers-to-empathy-in-the-clinical-encounter-a-qualitative-interview-study-with-gps
#18
Frans Awm Derksen, Tim C Olde Hartman, Jozien M Bensing, Antoine Lm Lagro-Janssen
BACKGROUND: Current daily general practice has become increasingly technical and somatically oriented (where attention to patients' feelings is decreased) due to an increase in protocol-based guidelines. Priorities in GP-patient communication have shifted from a focus on listening and empathy to task-oriented communication. AIM: To explore what barriers GPs experience when applying empathy in daily practice, and how these barriers are managed. DESIGN AND SETTING: Thirty Dutch GPs with sufficient heterogeneity in sex, age, type of practice, and rural or urban setting were interviewed...
December 2016: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/27884401/the-make-love-not-war-ape-bonobos-and-late-twentieth-century-explanations-for-war-and-peace
#19
Deborah Weinstein
Why do people fight wars? Following the devastation of the Second World War, this question became particularly pressing. Postwar scholars in the human sciences, from political science to anthropology, investigated the role of human nature in the causes of war even as they debated the very meaning of human nature itself. Among the wide-ranging efforts of postwar social and behavioral scientists to explain the causes of war, research on primate aggression became a compelling approach to studying the evolution of human warfare...
November 21, 2016: Endeavour
https://www.readbyqxmd.com/read/27884130/a-profile-of-the-clinical-course-of-cognition-and-comorbidity-in-mild-cognitive-impairment-and-dementia-study-the-4c-study-two-complementary-longitudinal-clinical-cohorts-in-the-netherlands
#20
Weiqi Liao, Renske E G Hamel, Marcel G M Olde Rikkert, Saskia M Oosterveld, Pauline Aalten, Frans R J Verhey, Philip Scheltens, Nicole Sistermans, Yolande A L Pijnenburg, Wiesje M van der Flier, Inez H G B Ramakers, René J F Melis
BACKGROUND: Heterogeneous disease trajectories of mild cognitive impairment (MCI) and dementia are frequently encountered in clinical practice, but there is still insufficient knowledge to understand the reasons and mechanisms causing this heterogeneity. In addition to correlates of the disorder, patient characteristics such as their health status, social environment, comorbidities and frailty may contribute to variability in trajectories over time. The current paper outlines the study design and the study population of and provides an overview of the data collected in the Clinical Course of Cognition and Comorbidity in Mild Cognitive Impairment (4C-MCI cohort, n = 315) and Dementia (4C-Dementia cohort, n = 331) Study...
November 25, 2016: BMC Neurology
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