Minjie Gao, Hua Bai, Yogesh Jethava, Yujie Wu, Yuqi Zhu, Ye Yang, Jiliang Xia, Huojun Cao, Reinaldo Franqui-Machin, Kalyan Nadiminti, Gregory S Thomas, Mohamed E Salama, Peter Altevogt, Gail Bishop, Michael Tomasson, Siegfried Janz, Jumei Shi, Lijuan Chen, Ivana Frech, Guido Tricot, Fenghuang Zhan
BACKGROUND: Treatment failures in cancers, including multiple myeloma (MM), are most likely due to the persistence of a minor population of tumor-initiating cells (TICs), which are noncycling or slowly cycling and very drug resistant. METHODS: Gene expression profiling and real-time quantitative reverse transcription polymerase chain reaction were employed to define genes differentially expressed between the side-population cells, which contain the TICs, and the main population of MM cells derived from 11 MM patient samples...
May 1, 2020: Journal of the National Cancer Institute