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https://www.readbyqxmd.com/read/28651419/-significance-of-evaluating-the-severity-of-patients-with-extremely-severe-burn-by-platelet-count-recovery-in-the-early-stage-post-burn
#1
Y Wu, Q Zhang, J Liu, J J Tang, J X Zheng, M Liu
Objective: To retrospectively analyze the prognostic value of platelet count recovery in the early stage post burn for patients with extremely severe burn, so as to evaluate their severity. Methods: A study involving 244 adult patients with extremely severe burn admitted to our hospital from January 2006 to December 2015, conforming to the inclusion criteria, was conducted. Data of their demography, injury, transmission, disease change in hospital, and platelet count from post injury day (PID) 1 to 10 were collected...
May 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28651416/-clinical-effects-of-joint-active-system-on-the-treatment-of-joint-dysfunction-after-deep-burn
#2
T F Ru, F F Li, P Chen, H Luo, L Yuan, F Lei, Y L Tang, W G Xie
Objective: To observe the clinical effects of the Joint Active System on the treatment of joint dysfunction after deep burn. Methods: Twenty-two patients with joint dysfunction after deep burn were hospitalized in Institute of Burns of Tongren Hospital of Wuhan University & Wuhan Third Hospital from January 2015 to October 2016, involving 18 elbow joints with flexion disorder, 10 wrist joints with dorsal extension disorder, and 12 ankle joints with dorsal extension disorder. They were treated with the elbow joint activity training device, the wrist joint activity training device, and the ankle joint activity training device of the Joint Active System, respectively...
May 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28651409/-drug-susceptibility-test-guided-therapy-and-novel-empirical-quadruple-therapy-for-helicobacter-pylori-infection-a-network-meta-analysis
#3
Q Y Gou, R B Yu, R H Shi
Objective: To compare the efficacy and the risk of adverse effect of drug susceptibility test guided therapy and novel empirical quadruple therapy for Helicobacter (H.) pylori infection. Methods: Literature retrieval was conducted by using major databases. Related papers published up to June 2015 were considered eligible if they were randomized control trials comparing different pharmacological formulations for H. pylori infection and used in a network Meta-analysis and a single rate Meta-analysis to evaluate the relative and absolute rates of H...
May 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28651408/-identification-and-evaluation-of-t-cell-epitopes-of-rv0585c-from-mycobacterium-tuberculosis
#4
X X Wang, X Chen, Y Q Li, T Y Xiao, Y Jiang, M C Li, H C Liu, K L Wan
Objective: To investigate the human T cell epitopes of Mycobacterium (M.) tuberculosis Rv0585c protein antigen and their immunogenicity and provide evidence for the development of specific tuberculosis immune diagnostic techniques and tuberculosis vaccine. Methods: We synthesized peptides from M. tuberculosis Rv0585c protein antigen predicted by TE-predict and IEDB human T cell epitope prediction tool. The cellular immunoreactivity of the predicted peptides was evaluated through ELISpot assay with the peripheral blood monouclear cells (PBMC) of clinical tuberculosis patients...
May 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28651407/-homology-analysis-and-historical-tracing-for-inter-continental-burkholderia-pseudomallei-strains-of-sequence-type-562
#5
X Zheng, L X Wang, H Wu, H Chen, X Zhu, J R He, L X Xia, W Li
Objective: To understand the homology of sequence type 562 (ST562) strains of Burkholderia pseudomallei which circulated in two separate continents (Asia and Australia) at different times. Methods:SpeⅠrestriction fragments and 4-locus multiple locus variable number tandem repeat analysis (MLVA-4) profiles were extracted from MSHR5858 (ST562 Australia strain) and 350105 (ST562 historical strain of Hainan) genomes respectively by in silico analysis and then compared with the PFGE and MLVA-4 results of five ST562 clinical isolates from Hainan to test their homology...
May 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28651405/-clinical-stages-and-outcomes-of-severe-cases-on-hand-foot-and-mouth-disease
#6
J Zhang, Y Jin, J L Sun, Y X Wang, X J Wang, X Q Fu, Z P Miao, J Lyu
Objective: To understand the characteristics and relation of clinical stage and outcome of severe cases on hand, foot and mouth disease (HFMD) and to establish the evaluation method for understanding severity of this disease. Methods: According to factors as geographical location, economic and epidemic levels, five provinces (Henan, Shandong, Yunnan, Zhejiang and Sichuan provinces) were selected. Reported severe cases of HFMD from the National Notifiable Diseases Reporting System were selected randomly in the five provinces...
May 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28651374/cd70-a-novel-target-of-car-t-cell-therapy-for-gliomas
#7
Linchun Jin, Haitao Ge, Yu Long, Changlin Yang, Yifan Emily Chang, Luyan Mu, Elias J Sayour, Gabriel De Leon, Qiong J Wang, James C Yang, Paul S Kubilis, Hongbo Bao, Songsong Xia, Dunyue Lu, Yingjun Kong, Li Hu, Yujiao Shang, Chencheng Jiang, Jing Nie, Shimin Li, Yunhe Gu, Jiahang Sun, Duane A Mitchell, Zhiguo Lin, Jianping Huang
Background: Cancer immunotherapy represents a promising treatment approach for malignant-gliomas, but is hampered by the limited number of ubiquitously expressed tumor antigens and the profoundly immunosuppressive tumor microenvironment. We identified CD70 as a novel immunosuppressive ligand and glioma target. Methods: Normal tissues derived from 52 different organs, and primary and recurrent low-grade gliomas (LGGs) and glioblastomas (GBMs) were thoroughly evaluated for CD70 gene and protein expression...
June 23, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28651338/evaluation-of-the-impact-of-tumor-hpv-status-on-outcome-in-patients-with-locally-advanced-unresectable-head-and-neck-squamous-cell-carcinoma-hnscc-receiving-cisplatin-5-fluorouracil-with-or-without-docetaxel-a-subset-analysis-of-eortc-24971-study
#8
A Psyrri, C Fortpied, G Koutsodontis, M Avgeris, C Kroupis, N Goutas, J Menis, L Herman, L Giurgea, E Remenar, M Degardin, I S Pateras, J A Langendijk, C van Herpen, A Awada, J R Germà-Lluch, H R Kienzer, L Licitra, J B Vermorken
Background: EORTC 24971 was a phase III trial demonstrating superiority of induction regimen TPF over PF, in terms of progression-free (PFS) and overall survival (OS) in locoregionally advanced unresectable HNSCC. We conducted a retrospective analysis of prospectively collected data aiming to evaluate whether only HPV(-) patients (pts) benefit from adding docetaxel to PF, in which case de-intensifying induction treatment in HPV(+) pts could be considered. Methods: Pre-therapy tumor biopsies (blocks or slides) were assessed for high-risk HPV by p16 immunohistochemistry, PCR and qPCR...
June 23, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28651262/relationship-of-radiographic-osteoarthritis-severity-with%C3%A2-treatment-outcomes-after-imaging-guided-knee%C3%A2-injections-a-prospective-outcomes-study
#9
Ivan Miletic, Christoph Agten, Reto Sutter, Christian Pfirrmann, Cynthia Peterson
Introduction To be able to predict which patients are more likely to have a positive treatment outcome, the purpose of this study is 1: To compare outcomes after intra-articular corticosteroid knee injections with the Kellgren and Lawrence (KL) 5 and 3 grading systems for knee osteoarthritis, the Osteoarthritis Research Society International (OARSI) grading system and actual joint space measurements; and 2: To compare the reliability of these grading systems. Materials and Methods Knee radiographs of 117 patients who received intra-articular corticosteroid injections were independently evaluated by two radiologists blinded to the outcome...
June 26, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28651231/evaluation-of-in-vitro-anticancer-activity-of-1-8-cineole-containing-n-hexane-extract-of-callistemon-citrinus-curtis-skeels-plant-and-its-apoptotic-potential
#10
Sowndarya Sampath, Vidhya Veeramani, Gopal Shankar Krishnakumar, Udhayakumar Sivalingam, Suguna Lakshmi Madurai, Rose Chellan
Plants are the source of a variety of secondary metabolites, which are often used in the anticancer activity. Discovering new anticancer drug from herbal source is more important in both biological and pharmacological activities. Hence, the objective of this study is to identify the anticancer agent in Callistemon citrinus (Curtis) Skeels (CC) for the treatment of cancer. Very recently we have reported an increased antioxidant activity in the ethanolic and methanolic extracts (EE and ME) of CC but significantly reduced activity (rather increased cytotoxicity), in the n-hexane extract (HE)...
June 23, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28651230/comparative-proteomic-and-metabolomic-studies-between-prunus-persica-genotypes-resistant-and-susceptible-to-taphrina-deformans-suggest-a-molecular-basis-of-resistance
#11
Camila Goldy, Laura A Svetaz, Claudia A Bustamante, Marco Allegrini, Gabriel H Valentini, María F Drincovich, Alisdair R Fernie, María V Lara
The worldwide-distributed leaf peach curl disease is caused by the biotroph Taphrina deformans. To characterize the plant-fungus interaction, resistant and susceptible Prunus persica genotypes grown in the orchard were studied. Asymptomatic leaves were tested for fungal presence. In all resistant leaves analyzed the fungus was not detected. Conversely, leaves from the susceptible genotype were categorized according to the presence or absence of the pathogen. Comparative metabolomic analysis disclosed the metabolite composition associated with resistant and susceptible interactions, and of compounds involved in fungal growth inhibition such as chlorogenic acid, whose in vitro antifungal activity was verified in this work...
June 17, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28651213/reward-related-frontostriatal-activity-and-smoking-behavior-among-adolescents-in-treatment-for-smoking-cessation
#12
Kathleen A Garrison, Sarah W Yip, Iris M Balodis, Kathleen M Carroll, Marc N Potenza, Suchitra Krishnan-Sarin
BACKGROUND: Tobacco use is often initiated during adolescence and continued into adulthood despite desires to quit. A better understanding of the neural correlates of abstinence from smoking in adolescents may inform more effective smoking cessation interventions. Neural reward systems are implicated in tobacco use disorder, and adolescent smokers have shown reduced reward-related ventral striatal activation related to increased smoking. METHODS: The current study evaluated nondrug reward anticipation in adolescent smokers using a monetary incentive delay task in fMRI pre- and post- smoking cessation treatment (n=14)...
June 3, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28651158/prospective-validation-of-a-lymphocyte-infiltration-prognostic-test-in-stage-iii-colon-cancer-patients-treated-with-adjuvant-folfox
#13
Jean-François Emile, Catherine Julié, Karine Le Malicot, Come Lepage, Josep Tabernero, Enrico Mini, Gunnar Folprecht, Jean-Luc Van Laethem, Stéphanie Dimet, Camille Boulagnon-Rombi, Marc-Antoine Allard, Frédérique Penault-Llorca, Jaafar Bennouna, Pierre Laurent-Puig, Julien Taieb
BACKGROUND: The prognostic value of lymphocyte infiltration (LI) of colorectal carcinoma (CC) has been demonstrated by several groups. However, no validated test is currently available for clinical practice. We previously described an automated and reproducible method for testing LI and aimed to validate it for clinical use. PATIENTS AND METHODS: According to National Institutes of Health criteria, we designed a prospective validation of this biomarker in patients included in the PETACC8 phase III study...
June 23, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28651093/the-effect-of-a-hydroxyapatite-impregnated-pcl-membrane-in-rat-subcritical-calvarial-bone-defects
#14
Monica Feresini Groppo, Paulo Henrique Caria, Alexandre Rodrigues Freire, Sidney R Figueroba, Wilson Alves Ribeiro-Neto, Rosario Elida Suman Bretas, Felippe Bevilacqua Prado, Francisco Haiter-Neto, Flavio Henrique Aguiar, Ana Claudia Rossi
OBJECTIVE: The present study evaluated the effect of polymeric-nanofibers membranes impregnated with microparticulate hydroxyapatite (HA) in the subcritical calvarial bone defects (SCBD) healing. DESIGN: PCL membranes with and without HA were obtained by electrospinning. SCBD were perforated (3.3mm) in left and right sides of 36 rat calvarias. The right-side SBCD of 18 animals was filled with HA mixed with blood clot and blood clot at the contralateral side. The remaining animals received PCL+HA membrane at the right-side SCBD and PCL membrane at the contralateral side...
June 15, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28651071/an-independent-active-contours-segmentation-framework-for-bone-micro-ct-images
#15
Vasileios Ch Korfiatis, Simone Tassani, George K Matsopoulos
Micro-CT is an imaging technique for small tissues and objects that is gaining increased popularity especially as a pre-clinical application. Nevertheless, there is no well-established micro-CT segmentation method, while typical procedures lack sophistication and frequently require a degree of manual intervention, leading to errors and subjective results. To address these issues, a novel segmentation framework, called Independent Active Contours Segmentation (IACS), is proposed in this paper. The proposed IACS is based on two autonomous modules, namely automatic ROI extraction and IAC Evolution, which segments the ROI image using multiple Active Contours that evolve simultaneously and independently of one another...
June 19, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28651060/mechanism-underlying-methyl-eugenol-attenuation-of-intestinal-ischemia-reperfusion-injury
#16
Hanan Saleh, Haidan M El-Shorbagy
Intestinal Ischemia/Reperfusion injury (I/R) is associated with a high risk of mortality in the clinical situation. Many factors are involved in I/R including reactive oxygen species (ROS), cytokine release and apoptosis. We aimed to determine whether a pure methyl eugenol (ME) given before intestinal ischemia, protects against intestinal I/R and the possible mechanism involved in this protection. Rat received ME (100 mg/kg) for 30 days then underwent intestinal I/R with 30 min ischemia and 60 min reperfusion...
June 26, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28651023/many-to-one-comparisons-after-safety-selection-in-multi-arm-clinical-trials
#17
Gerald Hlavin, Lisa V Hampson, Franz Koenig
In phase II platform trials, 'many-to-one' comparisons are performed when K experimental treatments are compared with a common control to identify the most promising treatment(s) to be selected for Phase III trials. However, when sample sizes are limited, such as when the disease of interest is rare, only a single Phase II/III trial addressing both treatment selection and confirmatory efficacy testing may be feasible. In this paper, we suggest a two-step safety selection and testing procedure for such seamless trials...
2017: PloS One
https://www.readbyqxmd.com/read/28651006/application-of-laboratory-and-portable-attenuated-total-reflectance-infrared-spectroscopic-approaches-for-rapid-quantification-of-alpaca-serum-immunoglobulin-g
#18
Ibrahim Elsohaby, Jennifer B Burns, Christopher B Riley, R Anthony Shaw, J Trenton McClure
The objective of this study was to develop and compare the performance of laboratory grade and portable attenuated total reflectance infrared (ATR-IR) spectroscopic approaches in combination with partial least squares regression (PLSR) for the rapid quantification of alpaca serum IgG concentration, and the identification of low IgG (<1000 mg/dL), which is consistent with the diagnosis of failure of transfer of passive immunity (FTPI) in neonates. Serum samples (n = 175) collected from privately owned, healthy alpacas were tested by the reference method of radial immunodiffusion (RID) assay, and laboratory grade and portable ATR-IR spectrometers...
2017: PloS One
https://www.readbyqxmd.com/read/28650987/accuracy-of-zika-virus-disease-case-definition-during-simultaneous-dengue-and-chikungunya-epidemics
#19
José Ueleres Braga, Clarisse Bressan, Ana Paula Razal Dalvi, Guilherme Amaral Calvet, Regina Paiva Daumas, Nadia Rodrigues, Mayumi Wakimoto, Rita Maria Ribeiro Nogueira, Karin Nielsen-Saines, Carlos Brito, Ana Maria Bispo de Filippis, Patrícia Brasil
BACKGROUND: Zika is a new disease in the American continent and its surveillance is of utmost importance, especially because of its ability to cause neurological manifestations as Guillain-Barré syndrome and serious congenital malformations through vertical transmission. The detection of suspected cases by the surveillance system depends on the case definition adopted. As the laboratory diagnosis of Zika infection still relies on the use of expensive and complex molecular techniques with low sensitivity due to a narrow window of detection, most suspected cases are not confirmed by laboratory tests, mainly reserved for pregnant women and newborns...
2017: PloS One
https://www.readbyqxmd.com/read/28650969/development-and-psychometric-properties-of-knee-specific-body-perception-questionnaire-in-people-with-knee-osteoarthritis-the-fremantle-knee-awareness-questionnaire
#20
Tomohiko Nishigami, Akira Mibu, Katsuyoshi Tanaka, Yuh Yamashita, Eiji Yamada, Benedict M Wand, Mark J Catley, Tasha R Stanton, G Lorimer Moseley
BACKGROUND: Recent systematic reviews have demonstrated that pain associated with knee osteoarthritis (OA) is a complex phenomenon that involves various contributors. People with knee OA exhibit symptoms of impaired body-perception, including reduced tactile acuity, impairments in limb laterality recognition, and degraded proprioceptive acuity. The Fremantle Back Awareness Questionnaire (FreBAQ) was developed to assess body-perception specific to the back in people with chronic low back pain...
2017: PloS One
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