Wireko Andrew Awuah, Arjun Ahluwalia, Shankaneel Ghosh, Sakshi Roy, Joecelyn Kirani Tan, Favour Tope Adebusoye, Tomas Ferreira, Hareesha Rishab Bharadwaj, Vallabh Shet, Mrinmoy Kundu, Amanda Leong Weng Yee, Toufik Abdul-Rahman, Oday Atallah
Single-cell ribonucleic acid sequencing (scRNA-seq) has emerged as a transformative technology in neurological and neurosurgical research, revolutionising our comprehension of complex neurological disorders. In brain tumours, scRNA-seq has provided valuable insights into cancer heterogeneity, the tumour microenvironment, treatment resistance, and invasion patterns. It has also elucidated the brain tri-lineage cancer hierarchy and addressed limitations of current models. Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis have been molecularly subtyped, dysregulated pathways have been identified, and potential therapeutic targets have been revealed using scRNA-seq...
November 16, 2023: European Journal of Medical Research