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https://www.readbyqxmd.com/read/29679103/slc30a8-polymorphism-and-bmi-complement-hla-a-24-as-risk-factors-for-poor-graft-function-in-islet-allograft-recipients
#1
Else M Balke, Simke Demeester, DaHae Lee, Pieter Gillard, Robert Hilbrands, Ursule Van de Velde, Bart J Van der Auwera, Zhidong Ling, Bart O Roep, Daniël G Pipeleers, Bart Keymeulen, Frans K Gorus
AIMS/HYPOTHESIS: HLA-A*24 carriership hampers achievement of insulin independence in islet allograft recipients. However, less than half of those who fail to achieve insulin independence carry the allele. We investigated whether genetic polymorphism at the recipients' zinc transporter 8-encoding SLC30A8 gene (rs13266634) could complement their HLA-A*24 status in predicting functional graft outcome. METHODS: We retrospectively analysed data of a hospital-based patient cohort followed for 18 months post transplantation...
April 20, 2018: Diabetologia
https://www.readbyqxmd.com/read/29678908/the-lim-homeodomain-protein-isl1-mediates-the-function-of-tcf7l2-in-pancreatic-beta-cells
#2
Weijuan Shao, Vivian Szeto, Zhuolun Song, Lili Tian, Zhong-Ping Feng, Cristina M Nostro, Tianru Jin
Pancreatic β-cell Tcf7l2 deletion or its functional knockdown suggested the essential role of this Wnt pathway effector in controlling insulin secretion, glucose homeostasis, and β-cell gene expression. As the LIM homeodomain protein Isl1 is a suggested Wnt pathway downstream target, we hypothesize that it mediates metabolic functions of Tcf7l2. We aimed to determine the role of Isl1 in mediating the function of Tcf7l2 and the incretin hormone GLP-1 in pancreatic β-cells. Effect of dominant negative TCF7L2 (TCF7L2DN) mediated Wnt pathway functional knockdown on Isl1 expression was determined in βTCFDN mouse islets and in the rat insulinoma cell line INS-1 832/13...
April 20, 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29678582/reversion-of-aging-related-dheas-decline-in-mouse-plasma-alleviates-aging-related-glucose-tolerance-impairment-by-potentiation-of-glucose-stimulated-insulin-secretion-of-acute-phase
#3
Junlei Ma, Jiang Yue, Rong Huang, Yu Liao, Shengxian Li, Wei Liu
AIMS/HYPOTHESIS: The latest research proposes mild age-related diabetes (MARD) as a subgroup of type 2 diabetes. While in human circulating dehydroepiandrosterone sulfate (DHEAS) decline with age is related to MARD, the role of circulating DHEAS in insulin secretion remains little known. METHODS: After intraperitoneal administration of glucose (2 g/kg) together with DHEAS (50 μg/kg) or equivalent DMSO to young (6-8 week old) or aging (12 month old) male C57BL/6 mice, plasma DHEAS and blood glucose were measured at indicated time point...
April 17, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29676546/alginate-catechol-cross-linking-interferes-with-insulin-secretion-capacity-in-isolated-murine-islet-cells
#4
Yu Sik Kim, Seung Woo Cho, Bomin Ko, Jisoo Shin, Chul Woo Ahn
Over the past three decades, human pancreatic islet isolation and transplantation techniques have developed as a routine clinical procedure for selected patients with type 1 diabetes mellitus. However, due to the donor shortage and required chronic systemic immunosuppression, the widespread application of islet transplantation is limited. To overcome these limitations, providing a physical barrier to transplanted islet cells with encapsulating biomaterial has emerged as a promising approach to enhance engraftment and promote islet survival post-transplantation...
April 2018: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/29675567/human-urine-derived-stem-cells-play-a-novel-role-in-the-treatment-of-stz-induced-diabetic-mice
#5
Tianxue Zhao, Deng Luo, Yun Sun, Xin Niu, Yang Wang, Chen Wang, Weiping Jia
Human urine-derived stem cells (hUSCs) are a potential stem cell source for cell therapy. However, the effect of hUSCs on glucose metabolism regulation in type 1 diabetes was not clear. Therefore, the aim of the study was to evaluate whether hUSCs have protective effect on streptozotocin (STZ)-induced diabetes. hUSCs were extracted and cultivated with a special culture medium. Flow cytometry analysis was applied to detect cell surface markers. BALB/c male nude mice were either injected with high-dose STZ (HD-STZ) or multiple low-dose STZ (MLD-STZ)...
April 19, 2018: Journal of Molecular Histology
https://www.readbyqxmd.com/read/29675560/patterns-of-differential-gene-expression-in-a-cellular-model-of-human-islet-development-and-relationship-to-type-2-diabetes-predisposition
#6
Marta Perez-Alcantara, Christian Honoré, Agata Wesolowska-Andersen, Anna L Gloyn, Mark I McCarthy, Mattias Hansson, Nicola L Beer, Martijn van de Bunt
AIMS/HYPOTHESIS: Most type 2 diabetes-associated genetic variants identified via genome-wide association studies (GWASs) appear to act via the pancreatic islet. Observed defects in insulin secretion could result from an impact of these variants on islet development and/or the function of mature islets. Most functional studies have focused on the latter, given limitations regarding access to human fetal islet tissue. Capitalising upon advances in in vitro differentiation, we characterised the transcriptomes of human induced pluripotent stem cell (iPSC) lines differentiated along the pancreatic endocrine lineage, and explored the contribution of altered islet development to the pathogenesis of type 2 diabetes...
April 19, 2018: Diabetologia
https://www.readbyqxmd.com/read/29675407/pancreatic-aquaporin-7-a-novel-target-for-anti-diabetic-drugs
#7
REVIEW
Leire Méndez-Giménez, Silvia Ezquerro, Inês V da Silva, Graça Soveral, Gema Frühbeck, Amaia Rodríguez
Aquaporins comprise a family of 13 members of water channels (AQP0-12) that facilitate a rapid transport of water across cell membranes. In some cases, these pores are also permeated by small solutes, particularly glycerol, urea or nitric oxide, among other solutes. Several aquaporins have been identified in the pancreas, an exocrine and endocrine organ that plays an essential role in the onset of insulin resistance and type 2 diabetes. The exocrine pancreas, which accounts for 90% of the total pancreas, secretes daily large volumes of a near-isotonic fluid containing digestive enzymes into the duodenum...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29675042/genetic-variability-in-eif2-%C3%AE-gene-is-associated-with-islet-%C3%AE-cell-function-in-the-development-of-diabetes-in-a-chinese-han-population
#8
Nan Gu, Xiaowei Ma, Jianwei Zhang, Mengmeng Jin, Nan Feng, Ruifen Deng, Ge Bai, Hong Zhang, Xiaohui Guo
Aims: Protein kinase-like endoplasmic reticulum kinase (PERK)/eukaryotic translation initiation factor 2 alpha ( eIF2α ) pathway mutations lead to failure of β -cell function. The aim of this article was to assess the association between eIF2α and the risk of glucose metabolism abnormalities. Methods: Two eIF2α SNPs (rs9840992 T>C and rs13072593 A>G) were selected based on CHB data from HapMap, and 1466 unrelated nondiabetes individuals were genotyped...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29674342/app-deficiency-results-in-resistance-to-obesity-but-impairs-glucose-tolerance-upon-high-fat-feeding
#9
Juliane Czeczor, Amanda Genders, Kathryn Aston-Mourney, Timothy Connor, Liam Hall, Kyoko Hasebe, Megan Ellis, Kirstie De Jong, Darren Henstridge, Peter Meikle, Mark Febbraio, Ken Walder, Sean L McGee
The amyloid precursor protein (APP) generates a number of peptides when processed through different cleavage mechanisms, including the Aβ peptide that is implicated in the development of Alzheimer's disease. It is well established that APP via its cleaved peptides regulates aspects of neuronal metabolism. Emerging evidence suggests that amyloidogenic processing of APP can lead to altered systemic metabolism, similar to that observed in metabolic disease states. In the present study, we investigated the effect of APP deficiency on obesity-induced alterations in systemic metabolism...
April 19, 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29673130/effects-of-gip-on-regional-blood-flow-during-normoglycemia-and-hyperglycemia-in-anesthetized-rats
#10
Xiang Gao, Andreas Lindqvist, Monica Sandberg, Leif Groop, Nils Wierup, Leif Jansson
The incretin hormone glucose-dependent insulinotropic polypeptide (GIP) potentiates glucose-stimulated insulin secretion, and affects β-cell turnover. This study aimed at evaluating if some of the beneficial effects of GIP on glucose homeostasis can be explained by modulation of islet blood flow. Anesthetized Sprague-Dawley rats were infused intravenously with different doses of GIP (10, 20, or 60 ng/kg*min) for 30 min. Subsequent organ blood flow measurements were performed with microspheres. In separate animals, islets were perfused ex vivo with GIP (10-6 -10-12  mol/L) during normo- and hyperglycemia and arteriolar responsiveness was recorded...
April 2018: Physiological Reports
https://www.readbyqxmd.com/read/29673066/total-pancreaticoduodenectomy-with-autologous-islet-transplantation-fourteen-years-after-liver-contained-composite-visceral-transplantation
#11
Ahmed Nassar, Cristiano Quintini, Guilherme Costa, Elizabeth Lennon, Rita Bottino, Betul Hatipoglu, Koji Hashimoto, Masato Fujiki, Fouad Kandeel, R Matthew Walsh, Kareem Abu-Elmagd
Chronic pancreatitis (CP) is a severely disabling disorder with potential detrimental effects on quality of life, gut function, and glucose homeostasis. Disease progression often results in irreversible morphological and functional abnormalities with development of chronic pain, mechanical obstruction, and pancreatic insufficiency. Along with comprehensive medical management, the concept of total pancreatectomy and islet autotransplantation (TP-AIT) was introduced forty years ago for patients with intractable pain and preserved beta-cell function...
April 19, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29673064/successful-pregnancy-and-delivery-after-simultaneous-islet-kidney-transplantation
#12
Michela Assalino, Michele Podetta, Sandrine Demuylder-Mischler, Katyuska Francini, Nadine Pernin, Jean-Pierre Randin, Domenico Bosco, Axel Andres, Thierry Berney
Allogeneic islet of Langerhans transplantation is a recognized beta-cell replacement therapy for patients affected by type 1 diabetes mellitus. Type 1 diabetes mellitus is a condition associated with an increased risk of adverse outcomes for pregnant women and fetuses We report the case of a 29 year-old woman with type 1 diabetes mellitus, who underwent successful allogeneic islet transplantation with simultaneous kidney transplantation. She achieved durable insulin independence after two islet infusions. Pregnancy was desired and planned 2 years after last islet infusion...
April 19, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29672250/correction-to-distinction-between-two-populations-of-islet-1-positive-cells-in-hearts-of-different-murine-strains-by-khattar-p-friedrich-fw-bonne-g-carrier-l-eschenhagen-t-evans-sm-schwartz-k-fiszman-my-and-vilquin-j-t-stem-cells-dev-2011-20-6-1043-1052-doi
#13
https://www.readbyqxmd.com/read/29671418/the-role-of-k-atp-channels-in-cerebral-ischemic-stroke-and-diabetes
#14
REVIEW
Vivian Szeto, Nai-Hong Chen, Hong-Shuo Sun, Zhong-Ping Feng
ATP-sensitive potassium (KATP ) channels are ubiquitously expressed on the plasma membrane of cells in multiple organs, including the heart, pancreas and brain. KATP channels play important roles in controlling and regulating cellular functions in response to metabolic state, which are inhibited by ATP and activated by Mg-ADP, allowing the cell to couple cellular metabolic state (ATP/ADP ratio) to electrical activity of the cell membrane. KATP channels mediate insulin secretion in pancreatic islet beta cells, and controlling vascular tone...
April 19, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29671177/tri-modal-in-vivo-imaging-of-pancreatic-islets-transplanted-subcutaneously-in-mice
#15
Sayuan Liang, Karim Louchami, Bryan Holvoet, Rein Verbeke, Christophe M Deroose, Bella Manshian, Stefaan J Soenen, Ine Lentacker, Uwe Himmelreich
PURPOSE: Transplantation of pancreatic islets (PIs) is a promising therapeutic approach for type 1 diabetes. The main obstacle for this strategy is that the outcome of islet engraftment depends on the engraftment site. It was our aim to develop a strategy for using non-invasive imaging techniques to assess the location and fate of transplanted PIs longitudinally in vivo. PROCEDURES: In order to overcome the limitations of individual imaging techniques and cross-validate findings by different modalities, we have combined fluorine magnetic resonance imaging (F-19 MRI), fluorescence imaging (FLI), and bioluminescent imaging (BLI) for studying subcutaneously transplanted PIs and beta cell-like cells (INS-1E cell line) in vivo...
April 18, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29671030/abnormal-islet-sphingolipid-metabolism-in-type-1-diabetes
#16
Laurits J Holm, Lars Krogvold, Jane P Hasselby, Simranjeet Kaur, Laura A Claessens, Mark A Russell, Clayton E Mathews, Kristian F Hanssen, Noel G Morgan, Bobby P C Koeleman, Bart O Roep, Ivan C Gerling, Flemming Pociot, Knut Dahl-Jørgensen, Karsten Buschard
AIMS/HYPOTHESIS: Sphingolipids play important roles in beta cell physiology, by regulating proinsulin folding and insulin secretion and in controlling apoptosis, as studied in animal models and cell cultures. Here we investigate whether sphingolipid metabolism may contribute to the pathogenesis of human type 1 diabetes and whether increasing the levels of the sphingolipid sulfatide would prevent models of diabetes in NOD mice. METHODS: We examined the amount and distribution of sulfatide in human pancreatic islets by immunohistochemistry, immunofluorescence and electron microscopy...
April 18, 2018: Diabetologia
https://www.readbyqxmd.com/read/29670917/pancreatic-beta-cell-death-novel-potential-mechanisms-in-diabetes-therapy
#17
REVIEW
Joselyn Rojas, Valmore Bermudez, Jim Palmar, María Sofía Martínez, Luis Carlos Olivar, Manuel Nava, Daniel Tomey, Milagros Rojas, Juan Salazar, Carlos Garicano, Manuel Velasco
Purpose of Review: Describing the diverse molecular mechanisms (particularly immunological) involved in the death of the pancreatic beta cell in type 1 and type 2 diabetes mellitus. Recent Findings: Beta cell death is the final event in a series of mechanisms that, up to date, have not been entirely clarified; it represents the pathophysiological mechanism in the natural history of diabetes mellitus. These mechanisms are not limited to an apoptotic process only, which is characteristic of the immune-mediated insulitis in type 1 diabetes mellitus...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29669939/cystic-fibrosis-related-diabetes-is-caused-by-islet-loss-and-inflammation
#18
Nathaniel J Hart, Radhika Aramandla, Gregory Poffenberger, Cody Fayolle, Ariel H Thames, Austin Bautista, Aliya F Spigelman, Jenny Aurielle B Babon, Megan E DeNicola, Prasanna K Dadi, William S Bush, Appakalai N Balamurugan, Marcela Brissova, Chunhua Dai, Nripesh Prasad, Rita Bottino, David A Jacobson, Mitchell L Drumm, Sally C Kent, Patrick E MacDonald, Alvin C Powers
Cystic fibrosis-related (CF-related) diabetes (CFRD) is an increasingly common and devastating comorbidity of CF, affecting approximately 35% of adults with CF. However, the underlying causes of CFRD are unclear. Here, we examined cystic fibrosis transmembrane conductance regulator (CFTR) islet expression and whether the CFTR participates in islet endocrine cell function using murine models of β cell CFTR deletion and normal and CF human pancreas and islets. Specific deletion of CFTR from murine β cells did not affect β cell function...
April 19, 2018: JCI Insight
https://www.readbyqxmd.com/read/29669745/gpr119-agonism-increases-glucagon-secretion-during-insulin-induced-hypoglycemia
#19
Nina Xiaoyan Li, Stacey Brown, Tim Kowalski, Margaret Wu, Liming Yang, Ge Dai, Aleksandr Petrov, Yuyan Ding, Tamara Dlugos, H Blair Woods, Liangsu Wang, Mark Erion, Robert Sherwin, David E Kelley
Insulin-induced hypoglycemia in diabetes is associated with impaired glucagon secretion. Here we tested whether stimulation of GPR119, a G-protein coupled receptor expressed in pancreatic islet as well as enteroendocrine cells, and previously shown to stimulate insulin and incretin secretion might enhance glucagon secretion during hypoglycemia. In the study, GPR119 agonists were applied to isolated islets or perfused pancreata perfusions to assess insulin and glucagon secretion during hypoglycemia or hyperglycemic conditions...
April 18, 2018: Diabetes
https://www.readbyqxmd.com/read/29669500/%C3%AE-cell-regenerative-potential-of-selected-herbal-extracts-in-alloxan-induced-diabetic-rats
#20
Anoja Priyadarshani Attanayake, Kamani Ayoma Perera Wijewardana Jayatilaka, Lakmini Kumari Boralugoda Mudduwa, Chitra Pathirana
Effective β-cell regeneration is a recognized therapeutic strategy in the treatment of type 1 diabetes mellitus. Regeneration of β-cells could be achieved via exogenous natural sources as medicinal plant extracts. Medicinal plants selected for the investigation were Spondias pinnata (Linn. f.) Kurz, Coccinia grandis (L.) Voigt and Gmelina arborea Roxb. The objective was to determine the β-cell regenerative potential of these plant extracts in alloxan induced diabetic rats. Alloxan monohydrate was used to induce diabetes (150 mg/kg, ip)...
April 18, 2018: Current Drug Discovery Technologies
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