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https://www.readbyqxmd.com/read/29779123/pulmonary-valve-replacement-after-repaired-tetralogy-of-fallot
#1
REVIEW
Hideki Tatewaki, Akira Shiose
In this review article, we describe pulmonary valve replacement (PVR) late after repaired Tetralogy of Fallot (TOF). Since the introduction of surgical intervention for patients with TOF in 1945, surgical management of TOF has dramatically improved early survival with mortality rates, less than 2-3%. However, the majority of these patients continue to experience residual right ventricular outflow tract pathology, most commonly pulmonary valve regurgitation (PR). The patients are generally asymptomatic during childhood and adolescence and, however, are at risk for severe PR later which can result in exercise intolerance, heart failure, arrhythmias, and sudden death...
May 19, 2018: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29776957/sudden-death-in-patients-with-severe-aortic-stenosis-observations-from-the-current-as-registry
#2
Tomohiko Taniguchi, Takeshi Morimoto, Hiroki Shiomi, Kenji Ando, Norio Kanamori, Koichiro Murata, Takeshi Kitai, Yuichi Kawase, Chisato Izumi, Takao Kato, Katsuhisa Ishii, Kazuya Nagao, Yoshihisa Nakagawa, Mamoru Toyofuku, Naritatsu Saito, Kenji Minatoya, Takeshi Kimura
BACKGROUND: The annual incidence of sudden death has been reported to be low (<1%/year) in asymptomatic patients with severe aortic stenosis (AS), and there is a paucity of data on the risk factors of sudden death in patients with severe AS. METHODS AND RESULTS: We evaluated the incidence and risk factors of sudden death during the median follow-up period of 1334 days in the Contemporary Outcomes After Surgery and Medical Treatment in Patients With Severe Aortic Stenosis (CURRENT AS) registry enrolling 3815 consecutive patients with severe AS between 2003 and 2011...
May 18, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29769222/transient-outward-k-current-i-to-underlies-the-right-ventricular-initiation-of-polymorphic-ventricular-tachycardia-in-a-transgenic-rabbit-model-of-long-qt-syndrome-type-1
#3
Bum-Rak Choi, Weiyan Li, Dmitry Terentyev, Anatoli Y Kabakov, Mingwang Zhong, Colin M Rees, Radmila Terentyeva, Tae Yun Kim, Zhilin Qu, Xuwen Peng, Alain Karma, Gideon Koren
BACKGROUND: Sudden death in long-QT syndrome type 1 (LQT1), an inherited disease caused by loss-of-function mutations in KCNQ1, is triggered by early afterdepolarizations (EADs) that initiate polymorphic ventricular tachycardia (pVT). We investigated ionic mechanisms that underlie pVT in LQT1 using a transgenic rabbit model of LQT1. METHODS: Optical mapping, cellular patch clamping, and computer modeling were used to elucidate the mechanisms of EADs in transgenic LQT1 rabbits...
June 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29768383/treatable-massive-pericardial-effusion-and-hypertrophic-cardiomyopathy-in-an-infant-with-a-novel-homozygous-acadvl-mutation-a-case-report
#4
Yoo-Mi Kim, Geena Kim, Hoon Ko, Han-Wook Yoo, Hyoung Doo Lee
RATIONALE: Infantile-onset hypertrophic cardiomyopathy (HCMP) should be considered a largely genetic condition, although its onset is most often triggered by infection. Very long chain acyl-CoA dehydrogenase (VLCAD) deficiency is a rare autosomal recessive inborn error of mitochondrial fatty acid β-oxidation that often causes severe cardiomyopathy and/or sudden death during the neonatal period. PATIENT CONCERNS: Herein, we report an infant with VLCAD deficiency who presented with severe cardiac manifestations, including massive pericardial effusion and HCMP...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29766218/qtl-mapping-and-epistatic-interaction-analysis-of-field-resistance-to-sudden-death-syndrome-fusarium-virguliforme-in-soybean
#5
Ruijuan Tan, Bradley Serven, Paul J Collins, Zhongnan Zhang, Zixiang Wen, John F Boyse, Cuihua Gu, Martin I Chilvers, Brian W Diers, Dechun Wang
Two interactive quantitative trait loci (QTLs) controlled the field resistance to sudden death syndrome (SDS) in soybean. The interaction between them was confirmed. Sudden death syndrome (SDS), caused by Fusarium virguliforme, is a major disease of soybean [Glycine max (L.) Merr.] in the United States. Breeding for soybean resistance to SDS is the most cost-effective method to manage the disease. The objective of this study was to identify and characterize quantitative trait loci (QTLs) underlying field resistance to SDS in a recombinant inbred line population from the cross GD2422 × LD01-5907...
May 15, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/29764707/mid-term-outcomes-from-a-multicenter-study-is-tevar-safe-for-ascending-aortic-dissection
#6
Qingsheng Lu, Lei Liu, Guangqi Chang, Xueming Chen, Hai Feng, Xuemin Zhang, Weiguo Fu, Zhihui Dong, Zaiping Jing
OBJECTIVES: This study aims to report mid-term follow-up outcomes of a series of TAAD patients treated with TEVAR in China. BACKGROUND: Thoracic endovascular aortic repair (TEVAR) has been used to treat type A aortic dissection (TAAD) for years. However, by comparing public reports, their outcomes which were based on different sample sizes show inconsistency. METHODS: Between January 2001 and December 2015, there were 56 patients with TAAD received TEVAR identified in 5 medical centers...
May 2, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29761670/arrhythmic-events-in-brugada-syndrome-a-nationwide-israeli-survey-of-the-clinical-characteristics-treatment-and-long-term-follow-up-israbru-vf
#7
Eran Leshem, Michael Rahkovich, Anna Mazo, Mahmoud Suleiman, Miri Blich, Avishag Laish-Farkash, Yuval Konstantino, Rami Fogelman, Boris Strasberg, Michael Geist, Israel Chetboun, Moshe Swissa, Michael Ilan, Aharon Glick, Yoav Michowitz, Raphael Rosso, Michael Glikson, Bernard Belhassen
BACKGROUND: Limited information exists about detailed clinical characteristics and management of the small subset of Brugada syndrome (BrS) patients who had an arrhythmic event (AE). OBJECTIVES: To conduct the first nationwide survey focused on BrS patients with documented AE. METHODS: Israeli electrophysiology units participated if they had treated BrS patients who had cardiac arrest (CA) (lethal/aborted; group 1) or experienced appropriate therapy for tachyarrhythmias after prophylactic implantable cardioverter defibrillator (ICD) implantation (group 2)...
May 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29754760/the-role-of-scube1-in-the-development-of-late-stent-thrombosis-presenting-with-st-elevation-myocardial-infarction
#8
Hasan Ata Bolayır, Tarık Kıvrak, Hakan Güneş, Dursun Akaslan, Ömer Şahin, Aslı Bolayır
INTRODUCTION AND AIM: There is an important link between platelets and inflammation, thrombosis, and vascular and tissue repair mechanisms. SCUBE1 (signal peptide-CUB-EGF domain-containing protein 1) may function as a novel platelet-endothelial adhesion molecule and play pathological roles in cardiovascular biology. Stent thrombosis (ST) following percutaneous coronary intervention is an uncommon and potentially catastrophic event that can manifest as myocardial infarction and sudden death...
May 10, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29753563/critical-appraisal-of-the-2018-acc-scientific-sessions-late-breaking-trials-from-a-statistician-s-perspective
#9
REVIEW
Stuart J Pocock, Tim J Collier
The late-breaking clinical trials presentations at the American College of Cardiology Scientific Sessions in March 2018 are an important contribution to the field of cardiology. This paper presents a constructive critical appraisal of 7 key studies: ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab), VEST (Vest Prevention of Early Sudden Death Trial), SECURE-PCI (Statins Evaluation in Coronary Procedures and Revascularization), TREAT (Ticagrelor in Patients with ST-Elevation Myocardial Infarction treated with Pharmacological Thrombolysis), POISE (PeriOperative ISchemic Evaluation), SMART-DATE (Safety of 6-Month Duration of Dual Antiplatelet Therapy After Percutaneous Coronary Intervention in Patients With Acute Coronary Syndrome), and CVD-REAL 2 (Comparative Effectiveness of Cardiovascular Outcomes in New Users of SGLT-2 Inhibitors)...
May 7, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29750726/slc22a5-mutations-in-a-patient-with-systemic-primary-carnitine-deficiency-and-cleft-palate-successful-perioperative-management
#10
Ching-Wei Hu, Ching-Hsuan Hu, Yah-Huei Wu-Chou, Lun-Jou Lo
BACKGROUND: Primary systemic carnitine deficiency (SCD) is an autosomal-recessive disorder caused by SLC22A5 gene mutation resulting in defective cellular carnitine transporter organic cation transporter 2. Defective carnitine transporter causes renal carnitine wasting and low serum carnitine. Carnitine is an essential cofactor for the transportation of long-chain fatty acids into the mitochondria. Lacking of carnitine may cause metabolic decompensation and sudden death when the patient is exposed to prolonged fasting before an operation...
May 10, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29750680/long-term-effects-of-antihypertensive-therapy-on-cardiovascular-events-and-new-onset-diabetes-mellitus-in-high-risk-hypertensive-patients-in-japan
#11
Jinliang Liu, Shinji Yasuno, Koji Oba, Manako Konda, Chikako Ichihara, Hiromi Kitao, Yoshihiro Kuwabara, Kenji Ueshima
OBJECTIVE: During the Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) trial, patients with hypertension who received amlodipine had similar cardiovascular risks as those who received candesartan. We conducted a post-trial study, the Candesartan Antihypertensive Survival Evaluation in Japan 10-year follow-up (CASE-J 10). This study aimed to confirm the long-term cardiovascular effects of candesartan and amlodipine. METHODS: Case report forms were sent to CASE-J investigators who agreed to participate in the CASE-J 10...
May 9, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29749943/experience-with-wearable-cardioverter-defibrillators-at-2-academic-medical-centers
#12
Jordan S Leyton-Mange, William J Hucker, Nino Mihatov, Matthew Reynolds, Christine Albert, Steven A Lubitz, David J Milan
OBJECTIVES: This study sought to characterize the experience in a cohort of patients prescribed a wearable cardioverter-defibrillator (WCD) over a 2-year interval at 2 academic medical centers. BACKGROUND: The WCD is available for patients felt to be at high risk of sudden cardiac death. However, there is a lack of randomized data to guide its use and prescribing patterns vary. METHODS: We retrospectively reviewed indications and therapies of all WCD prescriptions over a 2-year period from 2 large academic medical centers...
February 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29748973/afm-nano-mechanical-study-of-the-beating-profile-of-hipsc-derived-cardiomyocytes-beating-bodies-wt-and-dm1
#13
S Dinarelli, M Girasole, P Spitalieri, R V Talarico, M Murdocca, A Botta, G Novelli, R Mango, F Sangiuolo, G Longo
Myotonic Dystrophy type 1 (DM1) is the most common form of muscular dystrophy in adults, characterized by a variety of multisystemic features and associated with cardiac anomalies. Among cardiac phenomena, conduction defects, ventricular arrhythmias, and dilated cardiomyopathy represent the main cause of sudden death in DM1 patients. Patient-specific induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) represent a powerful in vitro model for molecular, biochemical, and physiological studies of disease in the target cells...
May 10, 2018: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/29748178/prognostic-significance-of-the-sodium-channel-blocker-test-in-patients-with-brugada-syndrome
#14
Akira Ueoka, Hiroshi Morita, Atsuyuki Watanabe, Yoshimasa Morimoto, Satoshi Kawada, Motomi Tachibana, Masakazu Miyamoto, Koji Nakagawa, Nobuhiro Nishii, Hiroshi Ito
BACKGROUND: A drug provocation test using a sodium channel blocker (SCB) can unmask a type 1 ECG pattern in patients with Brugada syndrome. However, the prognostic value of the results of an SCB challenge is limited in patients with non-type 1 ECG. We investigated the associations of future risk for ventricular fibrillation with SCB-induced ECG changes and ventricular tachyarrhythmias (VTAs). METHODS AND RESULTS: We administered intravenous pilsicainide to 245 consecutive patients with Brugada syndrome (181 patients with spontaneous type 1 ECG, 64 patients with non-type 1 ECG)...
May 10, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29747658/naxos-disease-from-the-origin-to-today
#15
REVIEW
Guo-Liang Li, Ardan M Saguner, Guy H Fontaine
Naxos disease, first described by Dr. Nikos Protonotarios and colleagues on the island of Naxos, Greece, is a special form of arrhythmogenic right ventricular dysplasia (ARVD). It is an inherited condition with a recessive form of transmission and a familial penetrance of 90%. It is associated with thickening of the skin of the hands and sole, and a propensity to woolly hair. The cardiac anomalies characterized by ventricular arrhythmias with ventricular extrasystoles and tachycardia and histologic features of the myocardium are consistent with ARVD, but in a more severe form of dysplasia with major dilatation of the right ventricle...
May 10, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29746987/age-and-benefit-of-early-coronary-angiography-after-out-of-hospital-cardiac-arrest-in-patients-presenting-with-shockable-rhythm-insights-from-the-sudden-death-expertise-center-registry
#16
Nadia Aissaoui, Wulfran Bougouin, Florence Dumas, Franckie Beganton, Richard Chocron, Olivier Varenne, Christian Spaulding, Nicole Karam, Gilles Montalescot, Pierre Aubry, Georges Sideris, Eloi Marijon, Xavier Jouven, Alain Cariou
BACKGROUND: Little is known about the association between provision of post-resuscitation care and prognosis of out-of-hospital cardiac arrest(OHCA) in elderly patients. Previous studies have suggested futility after 65 years of age. OBJECTIVES: We aimed to evaluate the association of early coronary angiogram(CAG) followed if necessary by percutaneous coronary intervention(PCI), with favorable outcome after OHCA among elderly patients, compared to younger patients...
May 7, 2018: Resuscitation
https://www.readbyqxmd.com/read/29743414/asn391thr-mutation-of-%C3%AE-myosin-heavy-chain-in-a-hypertrophic-cardiomyopathy-family
#17
Xiaotong Feng, Tingting He, Ji-Gang Wang, Peng Zhao
The present study was performed to identify the genetic abnormalities in a family with familial hypertrophic cardiomyopathy.Peripheral blood samples were collected from 22 members of a Chinese family with hypertrophic cardiomyopathy and 307 healthy controls. A total of 26 candidate pathogenic genes were analyzed in the proband using targeted capture sequencing. Identified mutations were analyzed using Sanger sequencing in all family members and healthy controls.A missense mutation (c.1172A>C, p. Asn391Thr) in exon 12 of MYH7 was identified in eight family members, among which six of them were hypertrophic cardiomyopathy carriers...
May 9, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29740701/characteristics-and-circadian-distribution-of-cardiac-arrhythmias-in-patients-with-heart-failure-and-sleep-disordered-breathing
#18
Hazem Omran, Thomas Bitter, Dieter Horstkotte, Olaf Oldenburg, Henrik Fox
BACKGROUND: Cardiac arrhythmias and sleep-disordered breathing (SDB) are common comorbidities in heart failure with reduced ejection fraction (HFrEF). However, understanding of the association between arrhythmias and SDB is poor. This study assessed the occurrence and circadian distribution of ventricular arrhythmias in HFrEF patients with and without SDB. METHODS: This retrospective analysis included HFrEF patients admitted for unattended overnight cardiorespiratory polygraphy and 24-h Holter-ECG recording...
May 8, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29740331/voltage-gated-sodium-channel-%C3%AE-1-%C3%AE-1b-subunits-regulate-cardiac-physiology-and-pathophysiology
#19
REVIEW
Nnamdi Edokobi, Lori L Isom
Cardiac myocyte contraction is initiated by a set of intricately orchestrated electrical impulses, collectively known as action potentials (APs). Voltage-gated sodium channels (NaV s) are responsible for the upstroke and propagation of APs in excitable cells, including cardiomyocytes. NaV s consist of a single, pore-forming α subunit and two different β subunits. The β subunits are multifunctional cell adhesion molecules and channel modulators that have cell type and subcellular domain specific functional effects...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29736818/transcriptome-profiling-reveals-phlda1-as-a-novel-molecular-marker-for-ischemic-cardiomyopathy
#20
Jinhui Wang, Feifei Wang, Jingbin Zhu, Mei Song, Jinghong An, Weimin Li
Ischemic cardiomyopathy (ICM) represents a worldwide health issue owning to its high sudden death rate. Easy diagnosis and effective treatment of ICM are still lacking. Identification of novel molecular markers will help illustrate the pathophysiology of ICM and facilitate its diagnosis and targeted treatment. Transcription profiling could be an easy and efficient way for identifying new markers. However, the mega data in the available database may contain a large number of false-positive hits. To identify the true marker for ICM, we systematically compared available microarray datasets in the GEO database and identified 26 genes that are shared by all datasets...
May 8, 2018: Journal of Molecular Neuroscience: MN
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