keyword
https://read.qxmd.com/read/36494221/management-of-patients-with-advanced-prostate-cancer-part-i-intermediate-high-risk-and-locally-advanced-disease-biochemical-relapse-and-side-effects-of-hormonal-treatment-report-of-the-advanced-prostate-cancer-consensus-conference-2022
#21
JOURNAL ARTICLE
Silke Gillessen, Alberto Bossi, Ian D Davis, Johann de Bono, Karim Fizazi, Nicholas D James, Nicolas Mottet, Neal Shore, Eric Small, Mathew Smith, Christopher Sweeney, Bertrand Tombal, Emmanuel S Antonarakis, Ana M Aparicio, Andrew J Armstrong, Gerhardt Attard, Tomasz M Beer, Himisha Beltran, Anders Bjartell, Pierre Blanchard, Alberto Briganti, Rob G Bristow, Muhammad Bulbul, Orazio Caffo, Daniel Castellano, Elena Castro, Heather H Cheng, Kim N Chi, Simon Chowdhury, Caroline S Clarke, Noel Clarke, Gedske Daugaard, Maria De Santis, Ignacio Duran, Ros Eeles, Eleni Efstathiou, Jason Efstathiou, Onyeanunam Ngozi Ekeke, Christopher P Evans, Stefano Fanti, Felix Y Feng, Valerie Fonteyne, Nicola Fossati, Mark Frydenberg, Daniel George, Martin Gleave, Gwenaelle Gravis, Susan Halabi, Daniel Heinrich, Ken Herrmann, Celestia Higano, Michael S Hofman, Lisa G Horvath, Maha Hussain, Barbara Alicja Jereczek-Fossa, Robert Jones, Ravindran Kanesvaran, Pirkko-Liisa Kellokumpu-Lehtinen, Raja B Khauli, Laurence Klotz, Gero Kramer, Raya Leibowitz, Christopher J Logothetis, Brandon A Mahal, Fernando Maluf, Joaquin Mateo, David Matheson, Niven Mehra, Axel Merseburger, Alicia K Morgans, Michael J Morris, Hind Mrabti, Deborah Mukherji, Declan G Murphy, Vedang Murthy, Paul L Nguyen, William K Oh, Piet Ost, Joe M O'Sullivan, Anwar R Padhani, Carmel Pezaro, Darren M C Poon, Colin C Pritchard, Danny M Rabah, Dana Rathkopf, Robert E Reiter, Mark A Rubin, Charles J Ryan, Fred Saad, Juan Pablo Sade, Oliver A Sartor, Howard I Scher, Nima Sharifi, Iwona Skoneczna, Howard Soule, Daniel E Spratt, Sandy Srinivas, Cora N Sternberg, Thomas Steuber, Hiroyoshi Suzuki, Matthew R Sydes, Mary-Ellen Taplin, Derya Tilki, Levent Türkeri, Fabio Turco, Hiroji Uemura, Hirotsugu Uemura, Yüksel Ürün, Claire L Vale, Inge van Oort, Neha Vapiwala, Jochen Walz, Kosj Yamoah, Dingwei Ye, Evan Y Yu, Almudena Zapatero, Thomas Zilli, Aurelius Omlin
BACKGROUND: Innovations in imaging and molecular characterisation and the evolution of new therapies have improved outcomes in advanced prostate cancer. Nonetheless, we continue to lack high-level evidence on a variety of clinical topics that greatly impact daily practice. To supplement evidence-based guidelines, the 2022 Advanced Prostate Cancer Consensus Conference (APCCC 2022) surveyed experts about key dilemmas in clinical management. OBJECTIVE: To present consensus voting results for select questions from APCCC 2022...
March 2023: European Urology
https://read.qxmd.com/read/35997413/criterion-referenced-assessment-of-intelligence-as-adaptation-to-the-environment-is-it-possible-plausible-or-practical
#22
JOURNAL ARTICLE
Robert J Sternberg, Aakash Chowkase, Fabio Andres Parra-Martinez, Jenna Landy
Criterion-referenced testing is usually applied to the assessment of achievement. In this article, we suggest how it can also be applied to the assessment of adaptive intelligence, that is, intelligence as adaptation to the environment. In the era of the Anthropocene, we argue that adaptive intelligence is what is most important not only for individual success, but also for success in terms of preservation of the world as we know it. We define criterion-referenced testing and compare it to norm-referenced testing...
August 16, 2022: Journal of Intelligence
https://read.qxmd.com/read/35997410/cultural-intelligence-what-is-it-and-how-can-it-effectively-be-measured
#23
JOURNAL ARTICLE
Robert J Sternberg, Ilaria Siriner, Jaime Oh, Chak Haang Wong
We administered both maximum-performance and typical-performance assessments of cultural intelligence to 114 undergraduates in a selective university in the Northeast of the United States. We found that cultural intelligence could be measured by both maximum-performance and typical-performance tests of cultural intelligence. Cultural intelligence as assessed by a maximum-performance measure is largely distinct from the construct as assessed by a typical-performance measure. The maximum-performance test, the Sternberg Test of Cultural Intelligence (SCIT), showed high internal consistency and inter-rater reliability...
August 5, 2022: Journal of Intelligence
https://read.qxmd.com/read/35736006/lessons-from-the-conservatory-model-as-a-basis-for-undergraduate-education-and-the-development-of-intelligence
#24
JOURNAL ARTICLE
Robert J Sternberg, Linda Jarvin, Ophélie Allyssa Desmet
We review the musical conservatory as a model for educators to learn how to enhance admissions, instruction, and assessment in liberal arts collegiate settings. Although conservatories serve primarily students wishing to enter musical careers of various kinds, the model on which they are based can, in many ways, serve any student and any school. We review some of the history of conservatories and describe how they work. Next, we explore how they develop a wide range of technical, cognitive, affective, and conative skills...
June 15, 2022: Journal of Intelligence
https://read.qxmd.com/read/35716665/b-cell-derived-cfdna-after-primary-bnt162b2-mrna-vaccination-anticipates-memory-b-cells-and-sars-cov-2-neutralizing-antibodies
#25
JOURNAL ARTICLE
Ilana Fox-Fisher, Sheina Piyanzin, Mayan Briller, Esther Oiknine-Djian, Or Alfi, Roni Ben-Ami, Ayelet Peretz, Daniel Neiman, Bracha-Lea Ochana, Ori Fridlich, Zeina Drawshy, Agnes Klochendler, Judith Magenheim, Danielle Share, Ran Avrahami, Yaarit Ribak, Aviv Talmon, Limor Rubin, Neta Milman, Meital Segev, Erik Feldman, Yuval Tal, Shai S Shen-Orr, Benjamin Glaser, Ruth Shemer, Dana Wolf, Yuval Dor
BACKGROUND: Much remains unknown regarding the response of the immune system to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccination. METHODS: We employed circulating cell-free DNA (cfDNA) to assess the turnover of specific immune cell types following administration of the Pfizer/BioNTech vaccine. FINDINGS: The levels of B cell cfDNA after the primary dose correlated with development of neutralizing antibodies and memory B cells after the booster, revealing a link between early B cell turnover-potentially reflecting affinity maturation-and later development of effective humoral response...
July 8, 2022: Med
https://read.qxmd.com/read/35645237/the-search-for-the-elusive-basic-processes-underlying-human-intelligence-historical-and-contemporary-perspectives
#26
JOURNAL ARTICLE
Robert J Sternberg
This article discusses the issues of the basic processes underlying intelligence, considering both historical and contemporary perspectives. The attempt to elucidate basic processes has had, at best, mixed success. There are some problems with pinpointing the underlying basic processes of intelligence, both in theory and as tested, such as what constitutes a basic process, what constitutes intelligence, and whether the processes, basic or not, are the same across time and space (cultural contexts). Nevertheless, the search for basic processes has elucidated phenomena of intelligence that the field would have been hard-pressed to elucidate in any other way...
May 13, 2022: Journal of Intelligence
https://read.qxmd.com/read/35592513/the-relationship-of-falls-with-achieved-25-hydroxyvitamin-d-levels-from-vitamin-d-supplementation-the-sturdy-trial
#27
JOURNAL ARTICLE
Erin D Michos, Rita R Kalyani, Amanda L Blackford, Alice L Sternberg, Christine M Mitchell, Stephen P Juraschek, Jennifer A Schrack, Amal A Wanigatunga, David L Roth, Robert H Christenson, Edgar R Miller, Lawrence J Appel
CONTEXT: The Study to Understand Fall Reduction and Vitamin D in You (STURDY), a randomized trial enrolling older adults with low 25-hydroxyvitamin D [25(OH)D], demonstrated vitamin D supplementation ≥ 1000 IU/day did not prevent falls compared with 200 IU/day, with doses ≥ 2000 IU/day potentially showing safety concerns. OBJECTIVE: To examine associations of achieved and change in 25(OH)D concentrations after 3 months of vitamin D supplementation with fall risk...
June 1, 2022: Journal of the Endocrine Society
https://read.qxmd.com/read/35568679/effects-of-metformin-and-statins-on-outcomes-in-men-with-castration-resistant-metastatic-prostate-cancer-secondary-analysis-of-cou-aa-301-and-cou-aa-302
#28
JOURNAL ARTICLE
Brooke E Wilson, Andrew J Armstrong, Johann de Bono, Cora N Sternberg, Charles J Ryan, Howard I Scher, Matthew R Smith, Dana Rathkopf, Christopher J Logothetis, Kim N Chi, Robert J Jones, Fred Saad, Peter De Porre, NamPhuong Tran, Peter Hu, Silke Gillessen, Joan Carles, Karim Fizazi, Anthony M Joshua
BACKGROUND: The associations of metformin and statins with overall survival (OS) and prostate specific antigen response rate (PSA-RR) in trials in metastatic castration-resistant prostate cancer remain unclear. OBJECTIVE: To determine whether metformin or statins ± abiraterone acetate plus prednisone/prednisolone (AAP) influence OS and PSA-RR. DESIGN, SETTING AND PARTICIPANT: COU-AA-301 and COU-AA-302 patients were stratified by metformin and statin use...
May 11, 2022: European Journal of Cancer
https://read.qxmd.com/read/35460922/peace-not-war-in-ukraine-or-anywhere-else-please
#29
EDITORIAL
Jean-Yves Lefrant, Romain Pirracchio, Dan Benhamou, Marc-Olivier Fischer, Rosanna Njeim, Bernard Allaouchiche, Sophie Bastide, Matthieu Biais, Lionel Bouvet, Olivier Brissaud, Sorin J Brull, Xavier Capdevila, Nicola Clausen, Philippe Cuvillon, Christophe Dadure, Jean-Stéphane David, Bin Du, Sharon Einav, Victoria Eley, Patrice Forget, Tomoko Fujii, Anne Godier, Dean P Gopalan, Sophie Hamada, Ahmed Hasanin, Olivier Joannes-Boyau, Sébastien Kerever, Éric Kipnis, Kerstin Kolodzie, Ruth Landau, Arthur Le Gall, Morgan Le Guen, Matthieu Legrand, Emmanuel Lorne, Frédéric J Mercier, Nicolas Mongardon, Sheila Myatra, Armelle Nicolas-Robin, Mark John Peters, Hervé Quintard, Jordi Rello, Philippe Richebé, Jason Alexander Roberts, Antoine Rocquilly, Filippo Sanfilippo, Antoine Schneider, Mircea T Sofonea, Francis Veyckemans, Paul Zetlaoui, Ahed Zeidan, Laurent Zieleskiewicz, Marzena Zielinska, Britta Von Ungern-Sternberg, Osama Abou Arab, Alice Blet, Fanny Bounes, Matthieu Boisson, Anaïs Caillard, Aude Carillion, Thomas Clavier, Denis Frasca, Arthur James, Stéphanie Sigaut, Sacha Rozencwajg, Pierre Albaladejo, Hervé Bouaziz
No abstract text is available yet for this article.
June 2022: Anaesthesia, Critical Care & Pain Medicine
https://read.qxmd.com/read/35450732/management-of-patients-with-advanced-prostate-cancer-report-from-the-advanced-prostate-cancer-consensus-conference-2021
#30
JOURNAL ARTICLE
Silke Gillessen, Andrew Armstrong, Gert Attard, Tomasz M Beer, Himisha Beltran, Anders Bjartell, Alberto Bossi, Alberto Briganti, Robert G Bristow, Muhammad Bulbul, Orazio Caffo, Kim N Chi, Caroline S Clarke, Noel Clarke, Ian D Davis, Johann S de Bono, Ignacio Duran, Ros Eeles, Eleni Efstathiou, Jason Efstathiou, Onyeanunam Ngozi Ekeke, Christopher P Evans, Stefano Fanti, Felix Y Feng, Karim Fizazi, Mark Frydenberg, Dan George, Martin Gleave, Susan Halabi, Daniel Heinrich, Celesta Higano, Michael S Hofman, Maha Hussain, Nick James, Robert Jones, Ravindran Kanesvaran, Raja B Khauli, Laurence Klotz, Raya Leibowitz, Chris Logothetis, Fernando Maluf, Robin Millman, Alicia K Morgans, Michael J Morris, Nicolas Mottet, Hind Mrabti, Declan G Murphy, Vedang Murthy, William K Oh, Piet Ost, Joe M O'Sullivan, Anwar R Padhani, Chris Parker, Darren M C Poon, Colin C Pritchard, Danny M Rabah, Dana Rathkopf, Rob E Reiter, Mark Rubin, Charles J Ryan, Fred Saad, Juan P Sade, Oliver Sartor, Howard I Scher, Neal Shore, Iwona Skoneczna, Eric Small, Matthew Smith, Howard Soule, Daniel E Spratt, Cora N Sternberg, Hiroyoshi Suzuki, Christopher Sweeney, Matthew R Sydes, Mary-Ellen Taplin, Derya Tilki, Bertrand Tombal, Levent Türkeri, Hiroji Uemura, Hirotsugu Uemura, Inge van Oort, Kosj Yamoah, Dingwei Ye, Almudena Zapatero, Aurelius Omlin
BACKGROUND: Innovations in treatments, imaging, and molecular characterisation in advanced prostate cancer have improved outcomes, but various areas of management still lack high-level evidence to inform clinical practice. The 2021 Advanced Prostate Cancer Consensus Conference (APCCC) addressed some of these questions to supplement guidelines that are based on level 1 evidence. OBJECTIVE: To present the voting results from APCCC 2021. DESIGN, SETTING, AND PARTICIPANTS: The experts identified three major areas of controversy related to management of advanced prostate cancer: newly diagnosed metastatic hormone-sensitive prostate cancer (mHSPC), the use of prostate-specific membrane antigen ligands in diagnostics and therapy, and molecular characterisation of tissue and blood...
July 2022: European Urology
https://read.qxmd.com/read/35440417/corrigendum-to-what-experts-think-about-prostate-cancer-management-during-the-covid-19-pandemic-report-from-the-advanced-prostate-cancer-consensus-conference-2021-eur-urol-2022
#31
Fabio Turco, Andrew Armstrong, Gerhardt Attard, Tomasz M Beer, Himisha Beltran, Anders Bjartell, Alberto Bossi, Alberto Briganti, Rob G Bristow, Muhammad Bulbul, Orazio Caffo, Kim N Chi, Caroline Clarke, Noel Clarke, Ian D Davis, Johann de Bono, Ignacio Duran, Ros Eeles, Eleni Efstathiou, Jason Efstathiou, Christopher P Evans, Stefano Fanti, Felix Y Feng, Karim Fizazi, Mark Frydenberg, Dan George, Martin Gleave, Susan Halabi, Daniel Heinrich, Celestia Higano, Michael S Hofman, Maha Hussain, Nicholas James, Rob Jones, Ravindran Kanesvaran, Raja B Khauli, Laurence Klotz, Raya Leibowitz, Christopher Logothetis, Fernando Maluf, Robin Millman, Alicia K Morgans, Michael J Morris, Nicolas Mottet, Hind Mrabti, Declan G Murphy, Vedang Murthy, William K Oh, Onyeanunam Ngozi Ekeke, Piet Ost, Joe M O'Sullivan, Anwar R Padhani, Christopher Parker, Darren M C Poon, Colin C Pritchard, Danny M Rabah, Dana Rathkopf, Robert E Reiter, Mark Rubin, Charles J Ryan, Fred Saad, Juan Pablo Sade, Oliver Sartor, Howard I Scher, Neal Shore, Iwona Skoneczna, Eric Small, Matthew Smith, Howard Soule, Daniel Spratt, Cora N Sternberg, Hiroyoshi Suzuki, Christopher Sweeney, Matthew Sydes, Mary-Ellen Taplin, Derya Tilki, Bertrand Tombal, Levent Türkeri, Hiroji Uemura, Hirotsugu Uemura, Inge van Oort, Kosj Yamoah, Dingwei Ye, Almudena Zapatero, Silke Gillessen, Aurelius Omlin
No abstract text is available yet for this article.
April 16, 2022: European Urology
https://read.qxmd.com/read/35416053/plain-language-summary-of-results-from-the-javelin-bladder-100-study-avelumab-maintenance-treatment-for-advanced-urothelial-cancer
#32
REVIEW
Thomas Powles, Se Hoon Park, Eric Voog, Claudia Caserta, Begoña P Valderrama, Howard Gurney, Haralabos Kalofonos, Sinisa Radulovic, Wim Demey, Anders Ullén, Yohann Loriot, Srikala S Sridhar, Norihiko Tsuchiya, Evgeny Kopyltsov, Cora N Sternberg, Joaquim Bellmunt, Jeanny B Aragon-Ching, Daniel P Petrylak, Robert J Laliberte, Bo Huang, Nuno Costa, John A Blake-Haskins, Petros Grivas
WHAT IS THIS SUMMARY ABOUT?: This is a plain language summary of an article originally published in The New England Journal of Medicine . It is about initial results (collected in October 2019) from the JAVELIN Bladder 100 study (a clinical trial), which looked at avelumab maintenance treatment in people with advanced urothelial cancer. Urothelial cancer is the most common type of bladder cancer. People with advanced urothelial cancer often receive chemotherapy. If this is the first treatment people with advanced disease are given, it is called first-line treatment...
June 2022: Future Oncology
https://read.qxmd.com/read/35393158/what-experts-think-about-prostate-cancer-management-during-the-covid-19-pandemic-report-from-the-advanced-prostate-cancer-consensus-conference-2021
#33
JOURNAL ARTICLE
Fabio Turco, Andrew Armstrong, Gerhardt Attard, Tomasz M Beer, Himisha Beltran, Anders Bjartell, Alberto Bossi, Alberto Briganti, Rob G Bristow, Muhammad Bulbul, Orazio Caffo, Kim N Chi, Caroline Clarke, Noel Clarke, Ian D Davis, Johann de Bono, Ignacio Duran, Ros Eeles, Eleni Efstathiou, Jason Efstathiou, Christopher P Evans, Stefano Fanti, Felix Y Feng, Karim Fizazi, Mark Frydenberg, Dan George, Martin Gleave, Susan Halabi, Daniel Heinrich, Celestia Higano, Michael S Hofman, Maha Hussain, Nicholas James, Rob Jones, Ravindran Kanesvaran, Raja B Khauli, Laurence Klotz, Raya Leibowitz, Christopher Logothetis, Fernando Maluf, Robin Millman, Alicia K Morgans, Michael J Morris, Nicolas Mottet, Hind Mrabti, Declan G Murphy, Vedang Murthy, William K Oh, Ngozi Ekeke Onyeanunam, Piet Ost, Joe M O'Sullivan, Anwar R Padhani, Christopher Parker, Darren M C Poon, Colin C Pritchard, Danny M Rabah, Dana Rathkopf, Robert E Reiter, Mark Rubin, Charles J Ryan, Fred Saad, Juan Pablo Sade, Oliver Sartor, Howard I Scher, Neal Shore, Iwona Skoneczna, Eric Small, Matthew Smith, Howard Soule, Daniel Spratt, Cora N Sternberg, Hiroyoshi Suzuki, Christopher Sweeney, Matthew Sydes, Mary-Ellen Taplin, Derya Tilki, Bertrand Tombal, Levent Türkeri, Hiroji Uemura, Hirotsugu Uemura, Inge van Oort, Kosj Yamoah, Dingwei Ye, Almudena Zapatero, Silke Gillessen, Aurelius Omlin
Patients with advanced prostate cancer (APC) may be at greater risk for severe illness, hospitalisation, or death from coronavirus disease 2019 (COVID-19) due to male gender, older age, potential immunosuppressive treatments, or comorbidities. Thus, the optimal management of APC patients during the COVID-19 pandemic is complex. In October 2021, during the Advanced Prostate Cancer Consensus Conference (APCCC) 2021, the 73 voting members of the panel members discussed and voted on 13 questions on this topic that could help clinicians make treatment choices during the pandemic...
July 2022: European Urology
https://read.qxmd.com/read/34940380/adaptive-intelligence-intelligence-is-not-a-personal-trait-but-rather-a-person-%C3%A3-task-%C3%A3-situation-interaction
#34
JOURNAL ARTICLE
Robert J Sternberg
This article explores the advantages of viewing intelligence not as a fixed trait residing within an individual, but rather as a person × task × situation interaction. The emphasis in the article is on the role of persons solving tasks embedded in situations involving learning, intellectual abilities, and competencies. The article opens with a consideration of the role of situations in intelligent behavior. The article then discusses how intelligence is more similar to creativity and wisdom, in terms of the role of situations, than many psychologists have realized...
November 26, 2021: Journal of Intelligence
https://read.qxmd.com/read/34638132/anti-cd25-radioimmunotherapy-with-beam-autologous-hematopoietic-cell-transplantation-conditioning-in-hodgkin-lymphoma
#35
JOURNAL ARTICLE
Alex F Herrera, Joycelynne M Palmer PhD, Vikram Adhikarla, Dave M Yamauchi, Erasmus Kofi Poku, James Bading, Paul Yazaki, Savita Dandapani, Matthew G Mei, Robert W Chen, Thai Cao, Nicole Amalia Karras, Pamela McTague, Auayporn Nademanee, Leslie Popplewell, Firoozeh Sahebi, John E Shively, Jennifer R Simpson, Diane Lynne Smith, Joo Song, Ricardo Spielberger, Ni-Chun Tsai, Sandra Holley Thomas, Stephen J Forman, David Colcher, Anna M Wu, Jeffrey Yc Wong, Eileen Patricia Smith
High-risk relapsed or refractory (R/R) classical Hodgkin lymphoma (HL) is associated with poor outcomes after conventional salvage therapy and autologous hematopoietic cell transplantation (AHCT). Post-AHCT consolidation with brentuximab vedotin (BV) improves progression-free survival (PFS), but with increasing use of BV early in the treatment course, the utility of consolidation is unclear. CD25 is often expressed on Reed-Sternberg cells and in the tumor microenvironment in HL and we hypothesized that the addition of 90Y-antiCD25 (aTac) to BEAM AHCT would be safe and result in a transplantation platform that is agnostic to prior HL-directed therapy...
October 12, 2021: Blood Advances
https://read.qxmd.com/read/34564293/understanding-and-assessing-cultural-intelligence-maximum-performance-and-typical-performance-approaches
#36
JOURNAL ARTICLE
Robert J Sternberg, Chak Haang Wong, Anastasia P Kreisel
Cultural intelligence is one's ability to adapt when confronted with problems arising in interactions with people or artifacts of diverse cultures. In this study, we conduct an initial construct-validation and assessment of a maximum-performance test of cultural intelligence. We assess the psychometric properties of the test and also correlate the test with other measures with which it might be expected there would be some connection. We found that our test was internally consistent and correlated significantly with maximum-performance tests of abilities but generally less or not at all with typical-performance tests, including cultural intelligence and openness to experience...
September 8, 2021: Journal of Intelligence
https://read.qxmd.com/read/34201680/integrating-diverse-points-of-view-on-intelligence-a-6p-framework-and-its-implications
#37
JOURNAL ARTICLE
Robert J Sternberg, Sareh Karami
This article introduces a 6P framework for understanding intelligence, as well as the theories and tests that are derived from it. The 6Ps in the framework are purpose, press, problems, persons, processes, and products underlying intelligence. Each of the 6Ps is considered in turn. We argue that although the purpose of intelligence is culturally universal, the other Ps can vary at least somewhat over time and space. A single theory or test of intelligence represents a particular configuration of the 6Ps, but other configurations of the 6Ps might yield different theories and different tests...
June 23, 2021: Journal of Intelligence
https://read.qxmd.com/read/34105517/jak2-rearrangements-are-a-recurrent-alteration-in-cd30-systemic-t-cell-lymphomas-with-anaplastic-morphology
#38
JOURNAL ARTICLE
Megan J Fitzpatrick, Lucas R Massoth, Chelsea Marcus, Jo-Anne Vergilio, Eric Severson, Daniel Duncan, Shakti H Ramkissoon, Robert P Hasserjian, Annette S Kim, Aliyah R Sohani, Erik A Williams, Valentina Nardi
Peripheral T-cell lymphoma (PTCL) comprises a heterogenous group of rare mature T-cell neoplasms. While some PTCL subtypes are well-characterized by histology, immunophenotype, and recurrent molecular alterations, others remain incompletely defined. In particular, the distinction between CD30+ PTCL, not otherwise specified and anaplastic lymphoma kinase (ALK)-negative anaplastic large cell lymphoma can be subject to disagreement. We describe a series of 6 JAK2 rearrangements occurring in a cohort of 97 CD30+ ALK- PTCL (6%), assembled after identifying an index case of a novel PABPC1-JAK2 fusion in a case of ALK- anaplastic large cell lymphoma with unusual classic Hodgkin lymphoma (CHL)-like features...
July 1, 2021: American Journal of Surgical Pathology
https://read.qxmd.com/read/33918262/meta-intelligence-understanding-control-and-interactivity-between-creative-analytical-practical-and-wisdom-based-approaches-in-problem-solving
#39
REVIEW
Robert J Sternberg, Vlad Glaveanu, Sareh Karami, James C Kaufman, Shane N Phillipson, David D Preiss
A deeper understanding of the processes leading to problem framing and behind finding solutions to problems should help explain variability in the quality of the solutions to those problems. Using Sternberg's WICS model as the conceptual basis of problem solving, this article discusses the relations between creative, analytical, practical, and wisdom-based approaches as bases for solutions to problems. We use a construct of meta-intelligence to encompass understanding, control, and coordination between these constructs...
April 2, 2021: Journal of Intelligence
https://read.qxmd.com/read/33822655/predicting-outcomes-in-men-with-metastatic-nonseminomatous-germ-cell-tumors-nsgct-results-from-the-igcccg-update-consortium
#40
MULTICENTER STUDY
Silke Gillessen, Nicolas Sauvé, Laurence Collette, Gedske Daugaard, Ronald de Wit, Costantine Albany, Alexey Tryakin, Karim Fizazi, Olof Stahl, Jourik A Gietema, Ugo De Giorgi, Fay H Cafferty, Aaron R Hansen, Torgrim Tandstad, Robert A Huddart, Andrea Necchi, Christopher J Sweeney, Xavier Garcia-Del-Muro, Daniel Y C Heng, Anja Lorch, Michal Chovanec, Eric Winquist, Peter Grimison, Darren R Feldman, Angelika Terbuch, Marcus Hentrich, Carsten Bokemeyer, Helene Negaard, Christian Fankhauser, Jonathan Shamash, David J Vaughn, Cora N Sternberg, Axel Heidenreich, Jörg Beyer
PURPOSE: The classification of the International Germ Cell Cancer Collaborative Group (IGCCCG) plays a pivotal role in the management of metastatic germ cell tumors but relies on data of patients treated between 1975 and 1990. MATERIALS AND METHODS: Data on 9,728 men with metastatic nonseminomatous germ cell tumors treated with cisplatin- and etoposide-based first-line chemotherapy between 1990 and 2013 were collected from 30 institutions or collaborative groups in Europe, North America, and Australia...
May 10, 2021: Journal of Clinical Oncology
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