keyword
https://read.qxmd.com/read/38586299/dual-process-model-of-courage
#1
JOURNAL ARTICLE
Aakash A Chowkase, Fabio Andrés Parra-Martínez, Mehdi Ghahremani, Zoe Bernstein, Gabrielle Finora, Robert J Sternberg
Courage is one of the most significant psychological constructs for society, but not one of the most frequently studied. This paper presents a process model of courage consisting of decision-based pathways by which one comes to enact a courageous action. We argue the process of courage begins with a trigger involving an actor(s) and a situation(s). The actor(s) then engage(s) in four key assessments concerning (a) immediacy of the situation, (b) meaningfulness, value, and relevance to the actor, (c) adequacy of efficacy to act, and (d) decision to act with courage...
2024: Frontiers in Psychology
https://read.qxmd.com/read/38564927/impact-of-teratoma-on-survival-probabilities-of-patients-with-metastatic-non-seminomatous-germ-cell-cancer-results-from-the-igcccg-update-consortium
#2
JOURNAL ARTICLE
Emanuel Bührer, David D'Haese, Gedske Daugaard, Ronald de Wit, Costantine Albany, Alexey Tryakin, Karim Fizazi, Olof Stahl, Jourik A Gietema, Ugo De Giorgi, Fay H Cafferty, Aaron R Hansen, Torgrim Tandstad, Robert A Huddart, Andrea Necchi, Christopher J Sweeney, Xavier Garcia-Del-Muro, Daniel Y C Heng, Anja Lorch, Michal Chovanec, Eric Winquist, Peter Grimison, Darren R Feldman, Angelika Terbuch, Marcus Hentrich, Carsten Bokemeyer, Helene Negaard, Christian Fankhauser, Jonathan Shamash, David J Vaughn, Cora N Sternberg, Axel Heidenreich, Laurence Collette, Silke Gillessen, Jörg Beyer
AIMS: To resolve the ongoing controversy surrounding the impact of teratoma (TER) in the primary among patients with metastatic testicular non-seminomatous germ-cell tumours (NSGCT). PATIENTS AND METHODS: Using the International Germ Cell Cancer Collaborative Group (IGCCCG) Update Consortium database, we compared the survival probabilities of patients with metastatic testicular GCT with TER (TER) or without TER (NTER) in their primaries corrected for known prognostic factors...
March 30, 2024: European Journal of Cancer
https://read.qxmd.com/read/38190514/extreme-drought-impacts-have-been-underestimated-in-grasslands-and-shrublands-globally
#3
JOURNAL ARTICLE
Melinda D Smith, Kate D Wilkins, Martin C Holdrege, Peter Wilfahrt, Scott L Collins, Alan K Knapp, Osvaldo E Sala, Jeffrey S Dukes, Richard P Phillips, Laura Yahdjian, Laureano A Gherardi, Timothy Ohlert, Claus Beier, Lauchlan H Fraser, Anke Jentsch, Michael E Loik, Fernando T Maestre, Sally A Power, Qiang Yu, Andrew J Felton, Seth M Munson, Yiqi Luo, Hamed Abdoli, Mehdi Abedi, Concepción L Alados, Juan Alberti, Moshe Alon, Hui An, Brian Anacker, Maggie Anderson, Harald Auge, Seton Bachle, Khadijeh Bahalkeh, Michael Bahn, Amgaa Batbaatar, Taryn Bauerle, Karen H Beard, Kai Behn, Ilka Beil, Lucio Biancari, Irmgard Blindow, Viviana Florencia Bondaruk, Elizabeth T Borer, Edward W Bork, Carlos Martin Bruschetti, Kerry M Byrne, James F Cahill, Dianela A Calvo, Michele Carbognani, Augusto Cardoni, Cameron N Carlyle, Miguel Castillo-Garcia, Scott X Chang, Jeff Chieppa, Marcus V Cianciaruso, Ofer Cohen, Amanda L Cordeiro, Daniela F Cusack, Sven Dahlke, Pedro Daleo, Carla M D'Antonio, Lee H Dietterich, Tim S Doherty, Maren Dubbert, Anne Ebeling, Nico Eisenhauer, Felícia M Fischer, T'ai G W Forte, Tobias Gebauer, Beatriz Gozalo, Aaron C Greenville, Karlo G Guidoni-Martins, Heather J Hannusch, Siri Vatsø Haugum, Yann Hautier, Mariet Hefting, Hugh A L Henry, Daniela Hoss, Johannes Ingrisch, Oscar Iribarne, Forest Isbell, Yari Johnson, Samuel Jordan, Eugene F Kelly, Kaitlin Kimmel, Juergen Kreyling, György Kröel-Dulay, Alicia Kröpfl, Angelika Kübert, Andrew Kulmatiski, Eric G Lamb, Klaus Steenberg Larsen, Julie Larson, Jason Lawson, Cintia V Leder, Anja Linstädter, Jielin Liu, Shirong Liu, Alexandra G Lodge, Grisel Longo, Alejandro Loydi, Junwei Luan, Frederick Curtis Lubbe, Craig Macfarlane, Kathleen Mackie-Haas, Andrey V Malyshev, Adrián Maturano-Ruiz, Thomas Merchant, Daniel B Metcalfe, Akira S Mori, Edwin Mudongo, Gregory S Newman, Uffe N Nielsen, Dale Nimmo, Yujie Niu, Paola Nobre, Rory C O'Connor, Romà Ogaya, Gastón R Oñatibia, Ildikó Orbán, Brooke Osborne, Rafael Otfinowski, Meelis Pärtel, Josep Penuelas, Pablo L Peri, Guadalupe Peter, Alessandro Petraglia, Catherine Picon-Cochard, Valério D Pillar, Juan Manuel Piñeiro-Guerra, Laura W Ploughe, Robert M Plowes, Cristy Portales-Reyes, Suzanne M Prober, Yolanda Pueyo, Sasha C Reed, Euan G Ritchie, Dana Aylén Rodríguez, William E Rogers, Christiane Roscher, Ana M Sánchez, Bráulio A Santos, María Cecilia Scarfó, Eric W Seabloom, Baoku Shi, Lara Souza, Andreas Stampfli, Rachel J Standish, Marcelo Sternberg, Wei Sun, Marie Sünnemann, Michelle Tedder, Pål Thorvaldsen, Dashuan Tian, Katja Tielbörger, Alejandro Valdecantos, Liesbeth van den Brink, Vigdis Vandvik, Mathew R Vankoughnett, Liv Guri Velle, Changhui Wang, Yi Wang, Glenda M Wardle, Christiane Werner, Cunzheng Wei, Georg Wiehl, Jennifer L Williams, Amelia A Wolf, Michaela Zeiter, Fawei Zhang, Juntao Zhu, Ning Zong, Xiaoan Zuo
Climate change is increasing the frequency and severity of short-term (~1 y) drought events-the most common duration of drought-globally. Yet the impact of this intensification of drought on ecosystem functioning remains poorly resolved. This is due in part to the widely disparate approaches ecologists have employed to study drought, variation in the severity and duration of drought studied, and differences among ecosystems in vegetation, edaphic and climatic attributes that can mediate drought impacts. To overcome these problems and better identify the factors that modulate drought responses, we used a coordinated distributed experiment to quantify the impact of short-term drought on grassland and shrubland ecosystems...
January 23, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38045425/updates-to-the-alliance-of-genome-resources-central-infrastructure-alliance-of-genome-resources-consortium
#4
Suzanne A Aleksander, Anna V Anagnostopoulos, Giulia Antonazzo, Valerio Arnaboldi, Helen Attrill, Andrés Becerra, Susan M Bello, Olin Blodgett, Yvonne M Bradford, Carol J Bult, Scott Cain, Brian R Calvi, Seth Carbon, Juancarlos Chan, Wen J Chen, J Michael Cherry, Jaehyoung Cho, Madeline A Crosby, Jeffrey L De Pons, Peter D'Eustachio, Stavros Diamantakis, Mary E Dolan, Gilberto Dos Santos, Sarah Dyer, Dustin Ebert, Stacia R Engel, David Fashena, Malcolm Fisher, Saoirse Foley, Adam C Gibson, Varun R Gollapally, L Sian Gramates, Christian A Grove, Paul Hale, Todd Harris, G Thomas Hayman, Yanhui Hu, Christina James-Zorn, Kamran Karimi, Kalpana Karra, Ranjana Kishore, Anne E Kwitek, Stanley J F Laulederkind, Raymond Lee, Ian Longden, Manuel Luypaert, Nicholas Markarian, Steven J Marygold, Beverley Matthews, Monica S McAndrews, Gillian Millburn, Stuart Miyasato, Howie Motenko, Sierra Moxon, Hans-Michael Muller, Christopher J Mungall, Anushya Muruganujan, Tremayne Mushayahama, Robert S Nash, Paulo Nuin, Holly Paddock, Troy Pells, Norbert Perrimon, Christian Pich, Mark Quinton-Tulloch, Daniela Raciti, Sridhar Ramachandran, Joel E Richardson, Susan Russo Gelbart, Leyla Ruzicka, Gary Schindelman, David R Shaw, Gavin Sherlock, Ajay Shrivatsav, Amy Singer, Constance M Smith, Cynthia L Smith, Jennifer R Smith, Lincoln Stein, Paul W Sternberg, Christopher J Tabone, Paul D Thomas, Ketaki Thorat, Jyothi Thota, Monika Tomczuk, Vitor Trovisco, Marek A Tutaj, Jose-Maria Urbano, Kimberly Van Auken, Ceri E Van Slyke, Peter D Vize, Qinghua Wang, Shuai Weng, Monte Westerfield, Laurens G Wilming, Edith D Wong, Adam Wright, Karen Yook, Pinglei Zhou, Aaron Zorn, Mark Zytkovicz
The Alliance of Genome Resources (Alliance) is an extensible coalition of knowledgebases focused on the genetics and genomics of intensively-studied model organisms. The Alliance is organized as individual knowledge centers with strong connections to their research communities and a centralized software infrastructure, discussed here. Model organisms currently represented in the Alliance are budding yeast, C. elegans , Drosophila , zebrafish, frog, laboratory mouse, laboratory rat, and the Gene Ontology Consortium...
November 22, 2023: bioRxiv
https://read.qxmd.com/read/38038856/correction-to-validation-of-the-short-version-tls-15-of-the-triangular-love-scale-tls-45-across-37-languages
#5
Marta Kowal, Piotr Sorokowski, Bojana M Dinić, Katarzyna Pisanski, Biljana Gjoneska, David A Frederick, Gerit Pfuhl, Taciano L Milfont, Adam Bode, Leonardo Aguilar, Felipe E García, S Craig Roberts, Beatriz Abad-Villaverde, Tina Kavčič, Kirill G Miroshnik, Izuchukwu L G Ndukaihe, Katarína Šafárová, Jaroslava V Valentova, Toivo Aavik, Angélique M Blackburn, Hakan Çetinkaya, Izzet Duyar, Farida Guemaz, Tatsunori Ishii, Pavol Kačmár, Jean C Natividade, Ravit Nussinson, Mohd Sofian B Omar-Fauzee, Ma Criselda T Pacquing, Koen Ponnet, Austin H Wang, Gyesook Yoo, Rizwana Amin, Ekaterine Pirtskhalava, Reza Afhami, Alexios Arvanitis, Derya Atamturk Duyar, Théo Besson, Mahmoud Boussena, Seda Can, Ali R Can, João Carneiro, Rita Castro, Dimitri Chubinidze, Ksenija Čunichina, Yahya Don, Seda Dural, Edgardo Etchezahar, Feten Fekih-Romdhane, Tomasz Frackowiak, Nasim Ghahraman Moharrampour, Talía Gómez Yepes, Simone Grassini, Marija Jovic, Kevin S Kertechian, Farah Khan, Aleksander Kobylarek, Valerija Križanić, Samuel Lins, Tetyana Mandzyk, Efisio Manunta, Tamara Martinac Dorčić, Kavitha N Muthu, Arooj Najmussaqib, Tobias Otterbring, Ju Hee Park, Irena Pavela Banai, Mariia Perun, Marc Eric S Reyes, Jan P Röer, Ayşegül Şahin, Fatima Zahra Sahli, Dušana Šakan, Sangeeta Singh, Sanja Smojver-Azic, Sinem Söylemez, Ognen Spasovski, Anna Studzinska, Ezgi Toplu-Demirtas, Arkadiusz Urbanek, Tatiana Volkodav, Anna Wlodarczyk, Mohd Faiz Mohd Y Yaakob, Mat Rahimi Yusof, Marcos Zumárraga-Espinosa, Maja Zupančič, Robert J Sternberg
No abstract text is available yet for this article.
December 1, 2023: Archives of Sexual Behavior
https://read.qxmd.com/read/37998711/cultural-intelligence-deployed-in-one-s-own-vs-in-a-different-culture-the-same-or-different
#6
JOURNAL ARTICLE
Robert J Sternberg, Caleb Co, Ilaria Siriner, Arezoo Soleimani-Dashtaki, Chak Haang Wong
Cultural intelligence is one's ability to adapt when confronted with problems arising in interactions with people or artifacts of cultures other than one's own. In this study, we explored two maximum-performance tests of cultural intelligence. One, used in previous research, measured cultural intelligence in the context of an individual conducting a business trip in another culture. The second, new to this research, measured cultural intelligence in the context of meeting someone from another culture while one is in the context of one's own culture...
November 7, 2023: Journal of Intelligence
https://read.qxmd.com/read/37971879/chronic-graft-versus-host-disease-detected-by-tissue-specific-cell-free-dna-methylation-biomarkers
#7
JOURNAL ARTICLE
Batia Avni, Daniel Neiman, Elior Shaked, Ofer Gal-Rosenberg, Sigal Grisariu, Mona Kuzli, Ilai Avni, Andrea Fracchia, Polina Stepensky, Tsila Zuckerman, Ahinoam Lev-Sagie, Ilana Fox-Fisher, Sheina Piyanzin, Joshua Moss, Seth J Salpeter, Benjamin Glaser, Ruth Shemer, Yuval Dor
BACKGROUND: Accurate detection of graft-versus-host disease (GVHD) is a major challenge in the management of patients undergoing hematopoietic stem cell transplantation (HCT). Here, we demonstrated the use of circulating cell-free DNA (cfDNA) for detection of tissue turnover and chronic GVHD (cGVHD) in specific organs. METHODS: We established a cocktail of tissue-specific DNA methylation markers and used it to determine the concentration of cfDNA molecules derived from the liver, skin, lungs, colon, and specific immune cells in 101 patients undergoing HCT...
January 16, 2024: Journal of Clinical Investigation
https://read.qxmd.com/read/37910143/ultra-deep-sequencing-reveals-the-mutational-landscape-of-classical-hodgkin-lymphoma
#8
JOURNAL ARTICLE
Felicia Gomez, Bryan Fisk, Joshua F McMichael, Matthew Mosior, Jennifer A Foltz, Zachary L Skidmore, Eric J Duncavage, Christopher A Miller, Haley Abel, Yi-Shan Lee, Kilannin Krysiak, David A Russler-Germain, Marcus P Watkins, Cody A Ramirez, Alina Schmidt, Fernanda Martins Rodrigues, Lee Trani, Ajay Khanna, Julia A Wagner, Robert S Fulton, Catrina C Fronick, Michelle D O'Laughlin, Timothy Schappe, Amanda F Cashen, Neha Mehta-Shah, Brad S Kahl, Jason Walker, Nancy L Bartlett, Malachi Griffith, Todd A Fehniger, Obi L Griffith
The malignant Hodgkin and Reed Sternberg (HRS) cells of classical Hodgkin lymphoma (cHL) are scarce in affected lymph nodes, creating a challenge to detect driver somatic mutations. As an alternative to cell purification techniques, we hypothesized that ultra-deep exome sequencing would allow genomic study of HRS cells, thereby streamlining analysis and avoiding technical pitfalls. To test this, 31 cHL tumor/normal pairs were exome sequenced to ~1000x median depth of coverage. An orthogonal error-corrected sequencing approach verified >95% of the discovered mutations...
November 1, 2023: Cancer Res Commun
https://read.qxmd.com/read/37884798/validation-of-the-short-version-tls-15-of-the-triangular-love-scale-tls-45-across-37-languages
#9
JOURNAL ARTICLE
Marta Kowal, Piotr Sorokowski, Bojana M Dinić, Katarzyna Pisanski, Biljana Gjoneska, David A Frederick, Gerit Pfuhl, Taciano L Milfont, Adam Bode, Leonardo Aguilar, Felipe E García, S Craig Roberts, Beatriz Abad-Villaverde, Tina Kavčič, Kirill G Miroshnik, Izuchukwu L G Ndukaihe, Katarína Šafárová, Jaroslava V Valentova, Toivo Aavik, Angélique M Blackburn, Hakan Çetinkaya, Izzet Duyar, Farida Guemaz, Tatsunori Ishii, Pavol Kačmár, Jean C Natividade, Ravit Nussinson, Mohd Sofian B Omar-Fauzee, Ma Criselda T Pacquing, Koen Ponnet, Austin H Wang, Gyesook Yoo, Rizwana Amin, Ekaterine Pirtskhalava, Reza Afhami, Alexios Arvanitis, Derya Atamturk Duyar, Théo Besson, Mahmoud Boussena, Seda Can, Ali R Can, João Carneiro, Rita Castro, Dimitri Chubinidze, Ksenija Čunichina, Yahya Don, Seda Dural, Edgardo Etchezahar, Feten Fekih-Romdhane, Tomasz Frackowiak, Nasim Ghahraman Moharrampour, Talía Gómez Yepes, Simone Grassini, Marija Jovic, Kevin S Kertechian, Farah Khan, Aleksander Kobylarek, Valerija Križanić, Samuel Lins, Tetyana Mandzyk, Efisio Manunta, Tamara Martinac Dorčić, Kavitha N Muthu, Arooj Najmussaqib, Tobias Otterbring, Ju Hee Park, Irena Pavela Banai, Mariia Perun, Marc Eric S Reyes, Jan P Röer, Ayşegül Şahin, Fatima Zahra Sahli, Dušana Šakan, Sangeeta Singh, Sanja Smojver-Azic, Sinem Söylemez, Ognen Spasovski, Anna Studzinska, Ezgi Toplu-Demirtas, Arkadiusz Urbanek, Tatiana Volkodav, Anna Wlodarczyk, Mohd Faiz Mohd Y Yaakob, Mat Rahimi Yusof, Marcos Zumárraga-Espinosa, Maja Zupančič, Robert J Sternberg
Love is a phenomenon that occurs across the world and affects many aspects of human life, including the choice of, and process of bonding with, a romantic partner. Thus, developing a reliable and valid measure of love experiences is crucial. One of the most popular tools to quantify love is Sternberg's 45-item Triangular Love Scale (TLS-45), which measures three love components: intimacy, passion, and commitment. However, our literature review reveals that most studies (64%) use a broad variety of shortened versions of the TLS-45...
October 26, 2023: Archives of Sexual Behavior
https://read.qxmd.com/read/37863196/comments-on-reducing-the-risks-of-nuclear-war-the-role-of-health-professionals
#10
EDITORIAL
Jean-Yves Lefrant, Dan Benhamou, Marc-Olivier Fischer, Romain Pirracchio, Bernard Allaouchiche, Sophie Bastide, Matthieu Biais, Alice Blet, Lionel Bouvet, Olivier Brissaud, Sorin J Brull, Xavier Capdevila, Nicola Clausen, Philippe Cuvillon, Christophe Dadure, Jean-Stéphane David, Victoria Eley, Patrice Forget, Tomoko Fujii, Anne Godier, Dean Gopalan, Pierre-Grégoire Guinot, Ahmed Hasanin, Olivier Joannes-Boyau, Sébastien Kerever, Éric Kipnis, Ruth Landau, Morgan Le Guen, Matthieu Legrand, Emmanuel Lorne, Frédéric Mercier, Nicolas Mongardon, Sheila Nainan Myatra, Armelle Nicolas-Robin, Mark John Peters, Hervé Quintard, Jordi Rello, Philippe G Richebe, Jason Alexander Roberts, Filippo Sanfilippo, Antoine Schneider, Mircea T Sofonea, Miriam Treggiari, Francis Veyckemans, Britta Regli Von Ungern-Sternberg, Ahed Zeidan, Laurent Zieleskiewicz, Marzena Zielinska, Alexandre Milman, Antoine Roquilly
No abstract text is available yet for this article.
October 18, 2023: Anaesthesia, Critical Care & Pain Medicine
https://read.qxmd.com/read/37714742/avelumab-first-line-maintenance-for-advanced-urothelial-carcinoma-analysis-from-javelin-bladder-100-by-duration-of-first-line-chemotherapy-and-interval-before-maintenance
#11
RANDOMIZED CONTROLLED TRIAL
Srikala S Sridhar, Thomas Powles, Miguel Á Climent Durán, Se Hoon Park, Francesco Massari, Antoine Thiery-Vuillemin, Begoña P Valderrama, Anders Ullén, Norihiko Tsuchiya, Jeanny B Aragon-Ching, Shilpa Gupta, Daniel P Petrylak, Joaquim Bellmunt, Jing Wang, Robert J Laliberte, Alessandra di Pietro, Nuno Costa, Petros Grivas, Cora N Sternberg, Yohann Loriot
BACKGROUND: In the JAVELIN Bladder 100 phase 3 trial, avelumab first-line maintenance + best supportive care (BSC) prolonged overall survival (OS) and progression-free survival (PFS) versus BSC alone in patients with advanced urothelial carcinoma (advanced UC) without progression after first-line platinum-based chemotherapy. OBJECTIVE: To report post hoc analyses of subgroups defined by the duration of first-line chemotherapy and interval before maintenance...
February 2024: European Urology
https://read.qxmd.com/read/37572790/what-can-ribo-seq-immunopeptidomics-and-proteomics-tell-us-about-the-non-canonical-proteome
#12
JOURNAL ARTICLE
John R Prensner, Jennifer G Abelin, Leron W Kok, Karl R Clauser, Jonathan M Mudge, Jorge Ruiz-Orera, Michal Bassani-Sternberg, Robert L Moritz, Eric W Deutsch, Sebastiaan van Heesch
Ribosome profiling (Ribo-seq) has proven transformative for our understanding of the human genome and proteome by illuminating thousands of non-canonical sites of ribosome translation outside of the currently annotated coding sequences (CDSs). A conservative estimate suggests that at least 7,000 non-canonical open reading frames (ORFs) are translated, which, at first glance, has the potential to expand the number of human protein-coding sequences by 30%, from ∼19,500 annotated CDSs to over 26,000. Yet, additional scrutiny of these ORFs has raised numerous questions about what fraction of them truly produce a protein product and what fraction of those can be understood as proteins according to conventional understanding of the term...
August 10, 2023: Molecular & Cellular Proteomics: MCP
https://read.qxmd.com/read/37121850/avelumab-first-line-maintenance-therapy-for-advanced-urothelial-carcinoma-comprehensive-clinical-subgroup-analyses-from-the-javelin-bladder-100-phase-3-trial
#13
RANDOMIZED CONTROLLED TRIAL
Petros Grivas, Se Hoon Park, Eric Voog, Claudia Caserta, Howard Gurney, Joaquim Bellmunt, Haralabos Kalofonos, Anders Ullén, Yohann Loriot, Srikala S Sridhar, Yoshiaki Yamamoto, Daniel P Petrylak, Cora N Sternberg, Shilpa Gupta, Bo Huang, Nuno Costa, Robert J Laliberte, Alessandra di Pietro, Begoña P Valderrama, Thomas Powles
BACKGROUND: In the phase 3 JAVELIN Bladder 100 trial, avelumab first-line (1L) maintenance + best supportive care (BSC) significantly prolonged overall survival (OS) and progression-free survival (PFS) versus BSC alone in patients with advanced urothelial carcinoma (aUC) who were progression-free following 1L platinum-based chemotherapy, leading to regulatory approval in various countries. OBJECTIVE: To analyze clinically relevant subgroups from JAVELIN Bladder 100...
July 2023: European Urology
https://read.qxmd.com/read/37071838/avelumab-first-line-maintenance-for-advanced-urothelial-carcinoma-results-from-the-javelin-bladder-100-trial-after-%C3%A2-2-years-of-follow-up
#14
JOURNAL ARTICLE
Thomas Powles, Se Hoon Park, Claudia Caserta, Begoña P Valderrama, Howard Gurney, Anders Ullén, Yohann Loriot, Srikala S Sridhar, Cora N Sternberg, Joaquim Bellmunt, Jeanny B Aragon-Ching, Jing Wang, Bo Huang, Robert J Laliberte, Alessandra di Pietro, Petros Grivas
Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned coprimary or secondary analyses are not yet available. Clinical trial updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported. Initial results from the phase III JAVELIN Bladder 100 trial (ClinicalTrials.gov identifier: NCT02603432) showed that avelumab first-line (1L) maintenance plus best supportive care (BSC) significantly prolonged overall survival (OS) and progression-free survival (PFS) versus BSC alone in patients with advanced urothelial carcinoma (aUC) who were progression-free after 1L platinum-containing chemotherapy...
April 18, 2023: Journal of Clinical Oncology
https://read.qxmd.com/read/37018920/pazopanib-in-locally-advanced-or-metastatic-renal-cell-carcinoma-results-of-a-randomized-phase-iii-trial
#15
JOURNAL ARTICLE
Cora N Sternberg, Ian D Davis, Jozef Mardiak, Cezary Szczylik, Eunsik Lee, John Wagstaff, Carlos H Barrios, Pamela Salman, Oleg A Gladkov, Alexander Kavina, Juan J Zarbá, Mei Chen, Lauren McCann, Lini Pandite, Debasish F Roychowdhury, Robert E Hawkins
PURPOSE: Pazopanib is an oral angiogenesis inhibitor targeting vascular endothelial growth factor receptor, platelet-derived growth factor receptor, and c-Kit. This randomized, double-blind, placebo-controlled phase III study evaluated efficacy and safety of pazopanib monotherapy in treatment-naive and cytokine-pretreated patients with advanced renal cell carcinoma (RCC). PATIENTS AND METHODS: Adult patients with measurable, locally advanced, and/or metastatic RCC were randomly assigned 2:1 to receive oral pazopanib or placebo...
April 10, 2023: Journal of Clinical Oncology
https://read.qxmd.com/read/37014980/patient-and-process-outcomes-among-pediatric-patients-undergoing-appendectomy-during-the-covid-19-pandemic-an-international-retrospective-cohort-study
#16
JOURNAL ARTICLE
Clyde T Matava, Nathaniel T G Tighe, Reto Baerschiger, Robert T Wilder, Lynnie Correll, Steven J Staffa, David Zurakowski, Meridith A Kato, Petra M Meier, Vidya Raman, Srijaya K Reddy, Remigio A Roque, Melissa Brooks Peterson, John Zhong, Thejovathi Edala, Timothy J Greer, Britta S von Ungern-Sternberg, Joseph Cravero, Allan F Simpao
BACKGROUND: COVID-19 forced healthcare systems to make unprecedented changes in clinical care processes. We hypothesized that the COVID-19 pandemic adversely impacted timely access to care, perioperative processes, and clinical outcomes for pediatric patients undergoing primary appendectomy. METHODS: We conducted a retrospective, international, multicenter study using matched cohorts within participating centers of the international PEdiatric Anesthesia COVID-19 Collaborative (PEACOC)...
April 4, 2023: Anesthesiology
https://read.qxmd.com/read/37003085/management-of-patients-with-advanced-prostate-cancer-metastatic-and-or-castration-resistant-prostate-cancer-report-of-the-advanced-prostate-cancer-consensus-conference-apccc-2022
#17
JOURNAL ARTICLE
Silke Gillessen, Alberto Bossi, Ian D Davis, Johann de Bono, Karim Fizazi, Nicholas D James, Nicolas Mottet, Neal Shore, Eric Small, Matthew Smith, Christopher J Sweeney, Bertrand Tombal, Emmanuel S Antonarakis, Ana M Aparicio, Andrew J Armstrong, Gerhardt Attard, Tomasz M Beer, Himisha Beltran, Anders Bjartell, Pierre Blanchard, Alberto Briganti, Rob G Bristow, Muhammad Bulbul, Orazio Caffo, Daniel Castellano, Elena Castro, Heather H Cheng, Kim N Chi, Simon Chowdhury, Caroline S Clarke, Noel Clarke, Gedske Daugaard, Maria De Santis, Ignacio Duran, Ross Eeles, Eleni Efstathiou, Jason Efstathiou, Onyeanunam Ngozi Ekeke, Christopher P Evans, Stefano Fanti, Felix Y Feng, Valerie Fonteyne, Nicola Fossati, Mark Frydenberg, Dan George, Martin Gleave, Gwenaelle Gravis, Susan Halabi, Daniel Heinrich, Ken Herrmann, Celestia Higano, Michael S Hofman, Lisa G Horvath, Maha Hussain, Barbara A Jereczek-Fossa, Rob Jones, Ravindran Kanesvaran, Pirkko-Liisa Kellokumpu-Lehtinen, Raja B Khauli, Laurence Klotz, Gero Kramer, Raja Leibowitz, Christopher Logothetis, Brandon Mahal, Fernando Maluf, Joaquin Mateo, David Matheson, Niven Mehra, Axel Merseburger, Alicia K Morgans, Michael J Morris, Hind Mrabti, Deborah Mukherji, Declan G Murphy, Vedang Murthy, Paul L Nguyen, William K Oh, Piet Ost, Joe M O'Sullivan, Anwar R Padhani, Carmel J Pezaro, Darren M C Poon, Colin C Pritchard, Danny M Rabah, Dana Rathkopf, Robert E Reiter, Mark A Rubin, Charles J Ryan, Fred Saad, Juan Pablo Sade, Oliver Sartor, Howard I Scher, Nima Sharifi, Iwona Skoneczna, Howard Soule, Daniel E Spratt, Sandy Srinivas, Cora N Sternberg, Thomas Steuber, Hiroyoshi Suzuki, Matthew R Sydes, Mary-Ellen Taplin, Derya Tilki, Levent Türkeri, Fabio Turco, Hiroji Uemura, Hirotsugu Uemura, Yüksel Ürün, Claire L Vale, Inge van Oort, Neha Vapiwala, Jochen Walz, Kosj Yamoah, Dingwei Ye, Evan Y Yu, Almudena Zapatero, Thomas Zilli, Aurelius Omlin
BACKGROUND: Innovations in imaging and molecular characterisation together with novel treatment options have improved outcomes in advanced prostate cancer. However, we still lack high-level evidence in many areas relevant to making management decisions in daily clinical practise. The 2022 Advanced Prostate Cancer Consensus Conference (APCCC 2022) addressed some questions in these areas to supplement guidelines that mostly are based on level 1 evidence. OBJECTIVE: To present the voting results of the APCCC 2022...
May 2023: European Journal of Cancer
https://read.qxmd.com/read/36939703/perspectives-of-patients-about-immediate-access-to-test-results-through-an-online-patient-portal
#18
JOURNAL ARTICLE
Bryan D Steitz, Robert W Turer, Chen-Tan Lin, Scott MacDonald, Liz Salmi, Adam Wright, Christoph U Lehmann, Karen Langford, Samuel A McDonald, Thomas J Reese, Paul Sternberg, Qingxia Chen, S Trent Rosenbloom, Catherine M DesRoches
IMPORTANCE: The 21st Century Cures Act Final Rule mandates the immediate electronic availability of test results to patients, likely empowering them to better manage their health. Concerns remain about unintended effects of releasing abnormal test results to patients. OBJECTIVE: To assess patient and caregiver attitudes and preferences related to receiving immediately released test results through an online patient portal. DESIGN, SETTING, AND PARTICIPANTS: This large, multisite survey study was conducted at 4 geographically distributed academic medical centers in the US using an instrument adapted from validated surveys...
March 1, 2023: JAMA Network Open
https://read.qxmd.com/read/36641519/modernization-collectivism-and-gender-equality-predict-love-experiences-in-45-countries
#19
JOURNAL ARTICLE
Piotr Sorokowski, Marta Kowal, Robert J Sternberg, Toivo Aavik, Grace Akello, Mohammad Madallh Alhabahba, Charlotte Alm, Naumana Amjad, Afifa Anjum, Kelly Asao, Chiemezie S Atama, Derya Atamtürk Duyar, Richard Ayebare, Daniel Conroy-Beam, Mons Bendixen, Aicha Bensafia, Boris Bizumic, Mahmoud Boussena, David M Buss, Marina Butovskaya, Seda Can, Antonin Carrier, Hakan Cetinkaya, Ilona Croy, Rosa María Cueto, Marcin Czub, Daria Dronova, Seda Dural, Izzet Duyar, Berna Ertugrul, Agustín Espinosa, Ignacio Estevan, Carla Sofia Esteves, Tomasz Frackowiak, Jorge Contreras Garduño, Karina Ugalde González, Farida Guemaz, Mária Halamová, Iskra Herak, Marina Horvat, Ivana Hromatko, Chin-Ming Hui, Jas Laile Jaafar, Feng Jiang, Konstantinos Kafetsios, Tina Kavčič, Leif Edward Ottesen Kennair, Nicolas Kervyn, Truong Thi Khanh Ha, Imran Ahmed Khilji, Nils C Köbis, Aleksandra Kostic, Hoang Moc Lan, András Láng, Georgina R Lennard, Ernesto León, Torun Lindholm, Trinh Thi Linh, Giulia Lopez, Nguyen Van Luot, Alvaro Mailhos, Zoi Manesi, Rocio Martinez, Sarah L McKerchar, Norbert Meskó, Marija Pejičić, Girishwar Misra, Conal Monaghan, Emanuel C Mora, Alba Moya-Garófano, Bojan Musil, Jean Carlos Natividade, George Nizharadze, Elisabeth Oberzaucher, Anna Oleszkiewicz, Mohd Sofian Omar-Fauzee, Ike E Onyishi, Baris Özener, Ariela Francesca Pagani, Vilmante Pakalniskiene, Miriam Parise, Farid Pazhoohi, Annette Pisanski, Katarzyna Pisanski, Edna Ponciano, Camelia Popa, Pavol Prokop, Muhammad Rizwan, Mario Sainz, Svjetlana Salkičević, Ruta Sargautyte, Ivan Sarmány-Schuller, Susanne Schmehl, Anam Shahid, Shivantika Sharad, Razi Sultan Siddiqui, Franco Simonetti, Meri Tadinac, Christin-Melanie Vauclair, Luis Diego Vega, Kathryn V Walter, Dwi Ajeng Widarini, Gyesook Yoo, Marta Zaťková, Maja Zupančič, Agnieszka Sorokowska
Recent cross-cultural and neuro-hormonal investigations have suggested that love is a near universal phenomenon that has a biological background. Therefore, the remaining important question is not whether love exists worldwide but which cultural, social, or environmental factors influence experiences and expressions of love. In the present study, we explored whether countries' modernization indexes are related to love experiences measured by three subscales (passion, intimacy, commitment) of the Triangular Love Scale...
January 14, 2023: Scientific Reports
https://read.qxmd.com/read/36547503/the-intelligent-attitude-what-is-missing-from-intelligence-tests
#20
JOURNAL ARTICLE
Robert J Sternberg
Intelligence, like creativity and wisdom, has an attitudinal component as well as an ability-based one. The attitudinal component is at least as important as the ability-based one. Theories of intelligence, in ignoring the attitudinal component of intelligence, have failed to account fully or accurately for why so many people who have relatively high levels of intelligence as an ability fail fully to deploy their ability, especially toward positive ends. The article reviews the need to view intelligence as comprising an attitude as well as an ability, and surveys reasons why people's lack of an intelligent attitude hinders their deployment of intelligence...
December 1, 2022: Journal of Intelligence
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