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robert J. Sternberg

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https://www.readbyqxmd.com/read/28902533/randomized-phase-iii-trial-of-adjuvant-pazopanib-versus-placebo-after-nephrectomy-in-patients-with-localized-or-locally-advanced-renal-cell-carcinoma
#1
Robert J Motzer, Naomi B Haas, Frede Donskov, Marine Gross-Goupil, Sergei Varlamov, Evgeny Kopyltsov, Jae Lyun Lee, Bohuslav Melichar, Brian I Rini, Toni K Choueiri, Milada Zemanova, Lori A Wood, M Neil Reaume, Arnulf Stenzl, Simon Chowdhury, Ho Yeong Lim, Ray McDermott, Agnieszka Michael, Weichao Bao, Marlene J Carrasco-Alfonso, Paola Aimone, Maurizio Voi, Christian Doehn, Paul Russo, Cora N Sternberg
Purpose This phase III trial evaluated the efficacy and safety of pazopanib versus placebo in patients with locally advanced renal cell carcinoma (RCC) at high risk for relapse after nephrectomy. Patients and Methods A total of 1,538 patients with resected pT2 (high grade) or ≥ pT3, including N1, clear cell RCC were randomly assigned to pazopanib or placebo for 1 year; 403 patients received a starting dose of 800 mg or placebo. To address toxicity attrition, the 800-mg starting dose was lowered to 600 mg, and the primary end point analysis was changed to disease-free survival (DFS) for pazopanib 600 mg versus placebo (n = 1,135)...
September 13, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28893733/topological-analysis-reveals-a-pd-l1-associated-microenvironmental-niche-for-reed-sternberg-cells-in-hodgkin-lymphoma
#2
Christopher D Carey, Daniel Gusenleitner, Mikel Lipschitz, Margaretha G M Roemer, Edward C Stack, Evisa Gjini, Xihao Hu, Robert Redd, Gordon J Freeman, Donna Neuberg, F Stephen Hodi, Xiaole Shirley Liu, Margaret A Shipp, Scott J Rodig
Signaling between programmed cell death protein 1 (PD-1) and the programmed cell death -1 ligands (PD-1 ligands, PD-L1, PD-L2) is essential for malignant Hodgkin Reed-Sternberg (HRS) cells to evade anti-tumor immunity in classical Hodgkin lymphoma (cHL). Copy number alterations of 9p24.1/CD274(PD-L1)/PDCD1LG2(PD-L2) contribute to robust PD-L1 and PD-L2 expression by HRS cells. PD-L1 is also expressed by non-malignant tumor-associated macrophages (TAMs) but the relationships between PD-L1+ HRS cells, PD-L1+ TAMs, and PD-1+ T-cells remain undefined...
September 11, 2017: Blood
https://www.readbyqxmd.com/read/28886907/final-efficacy-immunogenicity-and-safety-analyses-of-a-nine-valent-human-papillomavirus-vaccine-in-women-aged-16-26-years-a-randomised-double-blind-trial
#3
Warner K Huh, Elmar A Joura, Anna R Giuliano, Ole-Erik Iversen, Rosires Pereira de Andrade, Kevin A Ault, Deborah Bartholomew, Ramon M Cestero, Edison N Fedrizzi, Angelica L Hirschberg, Marie-Hélène Mayrand, Angela Maria Ruiz-Sternberg, Jack T Stapleton, Dorothy J Wiley, Alex Ferenczy, Robert Kurman, Brigitte M Ronnett, Mark H Stoler, Jack Cuzick, Suzanne M Garland, Susanne K Kjaer, Oliver M Bautista, Richard Haupt, Erin Moeller, Michael Ritter, Christine C Roberts, Christine Shields, Alain Luxembourg
BACKGROUND: Primary analyses of a study in young women aged 16-26 years showed efficacy of the nine-valent human papillomavirus (9vHPV; HPV 6, 11, 16, 18, 31, 33, 45, 52, and 58) vaccine against infections and disease related to HPV 31, 33, 45, 52, and 58, and non-inferior HPV 6, 11, 16, and 18 antibody responses when compared with quadrivalent HPV (qHPV; HPV 6, 11, 16, and 18) vaccine. We aimed to report efficacy of the 9vHPV vaccine for up to 6 years following first administration and antibody responses over 5 years...
September 5, 2017: Lancet
https://www.readbyqxmd.com/read/28727966/mountain-climbing-in-the-dark-introduction-to-the-special-symposium-on-the-future-direction-of-psychological-science
#4
Robert J Sternberg
This special symposium in Perspectives on Psychological Science answers the question, "Do you believe the field of psychological science is headed in the right direction?" Respondents are a sampling of Association for Psychological Science award winners over the past 5 years dating back from publication of this symposium.
July 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/28723513/the-natural-history-and-outcome-predictors-of-metastatic-castration-resistant-prostate-cancer
#5
REVIEW
Robert J van Soest, Jason A Efstathiou, Cora N Sternberg, Bertand Tombal
CONTEXT: Biomarkers for the treatment of metastatic castration-resistant prostate cancer (mCRPC) are urgently needed by clinicians to facilitate treatment decisions. OBJECTIVE: To review current prognostic and predictive biomarkers in mCRPC. EVIDENCE ACQUISITION: We performed a nonsystematic review of the literature from 2004 to August 2016 by searching in Medline. Cross-matching references were used to search for additional articles. We reviewed clinical research and review articles written in the English language...
December 2016: European Urology Focus
https://www.readbyqxmd.com/read/27899729/-am-i-famous-yet-judging-scholarly-merit-in-psychological-science-an-introduction
#6
Robert J Sternberg
The purpose of this symposium is to consider new ways of judging merit in academia, especially with respect to research in psychological science. First, I discuss the importance of merit-based evaluation and the purpose of this symposium. Next, I review some previous ideas about judging merit-especially creative merit-and I describe some of the main criteria used by institutions today for judging the quality of research in psychological science. Finally, I suggest a new criterion that institutions and individuals might use and draw some conclusions...
November 2016: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/27737878/classical-hodgkin-lymphoma-with-reduced-%C3%AE-2m-mhc-class-i-expression-is-associated-with-inferior-outcome-independent-of-9p24-1-status
#7
Margaretha G M Roemer, Ranjana H Advani, Robert A Redd, Geraldine S Pinkus, Yasodha Natkunam, Azra H Ligon, Courtney F Connelly, Christine J Pak, Christopher D Carey, Sarah E Daadi, Bjoern Chapuy, Daphne de Jong, Richard T Hoppe, Donna S Neuberg, Margaret A Shipp, Scott J Rodig
In classical Hodgkin lymphoma (cHL), malignant Hodgkin Reed-Sternberg (HRS) cells evade antitumor immunity by multiple mechanisms, including perturbed antigen presentation and enhanced PD-1 signaling. HRS cell expression of the PD-1 ligands is attributable, in part, to copy number alterations of 9p24.1/CD274(PD-L1)/PDCD1LG2(PD-L2) Amplification of PD-L1/PD-L2 is associated with advanced clinical stage and inferior progression-free survival (PFS) following first-line (induction) therapy. The relationships between altered expression of β2-microglobulin (β2M), MHC class I, and MHC class II by HRS cells, PD-L1/PD-L2 amplification, and clinical outcome in cHL are poorly defined...
November 2016: Cancer Immunology Research
https://www.readbyqxmd.com/read/27694460/introduction-to-optimizing-learning-in-college-tips-from-cognitive-psychology
#8
Robert J Sternberg
No abstract text is available yet for this article.
September 2016: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/27378885/oscillation-phase-locking-and-late-erp-components-of-intracranial-hippocampal-recordings-correlate-to-patient-performance-in-a-working-memory-task
#9
Jonathan K Kleen, Markus E Testorf, David W Roberts, Rod C Scott, Barbara J Jobst, Gregory L Holmes, Pierre-Pascal Lenck-Santini
In working memory tasks, stimulus presentation induces a resetting of intracranial temporal lobe oscillations in multiple frequency bands. To further understand the functional relevance of this phenomenon, we investigated whether working memory performance depends on the phase precision of ongoing oscillations in the hippocampus. We recorded intra-hippocampal local field potentials in individuals performing a working memory task. Two types of trials were administered. For high memory trials presentation of a list of four letters ("List") was followed by a single letter memory probe ("Test")...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27367781/genetics-and-genomics-of-longitudinal-lung-function-patterns-in-individuals-with-asthma
#10
Michael J McGeachie, Katherine P Yates, Xiaobo Zhou, Feng Guo, Alice L Sternberg, Mark L Van Natta, Robert A Wise, Stanley J Szefler, Sunita Sharma, Alvin T Kho, Michael H Cho, Damien C Croteau-Chonka, Peter J Castaldi, Gaurav Jain, Amartya Sanyal, Ye Zhan, Bryan R Lajoie, Job Dekker, John Stamatoyannopoulos, Ronina A Covar, Robert S Zeiger, N Franklin Adkinson, Paul V Williams, H William Kelly, Hartmut Grasemann, Judith M Vonk, Gerard H Koppelman, Dirkje S Postma, Benjamin A Raby, Isaac Houston, Quan Lu, Anne L Fuhlbrigge, Kelan G Tantisira, Edwin K Silverman, James Tonascia, Robert C Strunk, Scott T Weiss
RATIONALE: Patterns of longitudinal lung function growth and decline in childhood asthma have been shown to be important in determining risk for future respiratory ailments including chronic airway obstruction and chronic obstructive pulmonary disease. OBJECTIVES: To determine the genetic underpinnings of lung function patterns in subjects with childhood asthma. METHODS: We performed a genome-wide association study of 581 non-Hispanic white individuals with asthma that were previously classified by patterns of lung function growth and decline (normal growth, normal growth with early decline, reduced growth, and reduced growth with early decline)...
December 15, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27279544/cabozantinib-versus-everolimus-in-advanced-renal-cell-carcinoma-meteor-final-results-from-a-randomised-open-label-phase-3-trial
#11
RANDOMIZED CONTROLLED TRIAL
Toni K Choueiri, Bernard Escudier, Thomas Powles, Nizar M Tannir, Paul N Mainwaring, Brian I Rini, Hans J Hammers, Frede Donskov, Bruce J Roth, Katriina Peltola, Jae Lyun Lee, Daniel Y C Heng, Manuela Schmidinger, Neeraj Agarwal, Cora N Sternberg, David F McDermott, Dana T Aftab, Colin Hessel, Christian Scheffold, Gisela Schwab, Thomas E Hutson, Sumanta Pal, Robert J Motzer
BACKGROUND: Cabozantinib is an oral inhibitor of tyrosine kinases including MET, VEGFR, and AXL. The randomised phase 3 METEOR trial compared the efficacy and safety of cabozantinib versus the mTOR inhibitor everolimus in patients with advanced renal cell carcinoma who progressed after previous VEGFR tyrosine-kinase inhibitor treatment. Here, we report the final overall survival results from this study based on an unplanned second interim analysis. METHODS: In this open-label, randomised phase 3 trial, we randomly assigned (1:1) patients aged 18 years and older with advanced or metastatic clear-cell renal cell carcinoma, measurable disease, and previous treatment with one or more VEGFR tyrosine-kinase inhibitors to receive 60 mg cabozantinib once a day or 10 mg everolimus once a day...
July 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27168434/patterns-of-growth-and-decline-in-lung-function-in-persistent-childhood-asthma
#12
RANDOMIZED CONTROLLED TRIAL
M J McGeachie, K P Yates, X Zhou, F Guo, A L Sternberg, M L Van Natta, R A Wise, S J Szefler, S Sharma, A T Kho, M H Cho, D C Croteau-Chonka, P J Castaldi, G Jain, A Sanyal, Y Zhan, B R Lajoie, J Dekker, J Stamatoyannopoulos, R A Covar, R S Zeiger, N F Adkinson, P V Williams, H W Kelly, H Grasemann, J M Vonk, G H Koppelman, D S Postma, B A Raby, I Houston, Q Lu, A L Fuhlbrigge, K G Tantisira, E K Silverman, J Tonascia, S T Weiss, R C Strunk
BACKGROUND: Tracking longitudinal measurements of growth and decline in lung function in patients with persistent childhood asthma may reveal links between asthma and subsequent chronic airflow obstruction. METHODS: We classified children with asthma according to four characteristic patterns of lung-function growth and decline on the basis of graphs showing forced expiratory volume in 1 second (FEV1), representing spirometric measurements performed from childhood into adulthood...
May 12, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27069084/pd-l1-and-pd-l2-genetic-alterations-define-classical-hodgkin-lymphoma-and-predict-outcome
#13
Margaretha G M Roemer, Ranjana H Advani, Azra H Ligon, Yasodha Natkunam, Robert A Redd, Heather Homer, Courtney F Connelly, Heather H Sun, Sarah E Daadi, Gordon J Freeman, Philippe Armand, Bjoern Chapuy, Daphne de Jong, Richard T Hoppe, Donna S Neuberg, Scott J Rodig, Margaret A Shipp
PURPOSE: Classical Hodgkin lymphomas (cHLs) include small numbers of malignant Reed-Sternberg cells within an extensive but ineffective inflammatory/immune cell infiltrate. In cHL, chromosome 9p24.1/PD-L1/PD-L2 alterations increase the abundance of the PD-1 ligands, PD-L1 and PD-L2, and their further induction through Janus kinase 2-signal transducers and activators of transcription signaling. The unique composition of cHL limits its analysis with high-throughput genomic assays. Therefore, the precise incidence, nature, and prognostic significance of PD-L1/PD-L2 alterations in cHL remain undefined...
August 10, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/26903579/trial-design-and-objectives-for-castration-resistant-prostate-cancer-updated-recommendations-from-the-prostate-cancer-clinical-trials-working-group-3
#14
Howard I Scher, Michael J Morris, Walter M Stadler, Celestia Higano, Ethan Basch, Karim Fizazi, Emmanuel S Antonarakis, Tomasz M Beer, Michael A Carducci, Kim N Chi, Paul G Corn, Johann S de Bono, Robert Dreicer, Daniel J George, Elisabeth I Heath, Maha Hussain, Wm Kevin Kelly, Glenn Liu, Christopher Logothetis, David Nanus, Mark N Stein, Dana E Rathkopf, Susan F Slovin, Charles J Ryan, Oliver Sartor, Eric J Small, Matthew Raymond Smith, Cora N Sternberg, Mary-Ellen Taplin, George Wilding, Peter S Nelson, Lawrence H Schwartz, Susan Halabi, Philip W Kantoff, Andrew J Armstrong
PURPOSE: Evolving treatments, disease phenotypes, and biology, together with a changing drug development environment, have created the need to revise castration-resistant prostate cancer (CRPC) clinical trial recommendations to succeed those from prior Prostate Cancer Clinical Trials Working Groups. METHODS: An international expert committee of prostate cancer clinical investigators (the Prostate Cancer Clinical Trials Working Group 3 [PCWG3]) was reconvened and expanded and met in 2012-2015 to formulate updated criteria on the basis of emerging trial data and validation studies of the Prostate Cancer Clinical Trials Working Group 2 recommendations...
April 20, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/26901053/overall-survival-endpoint-in-oncology-clinical-trials-addressing-the-effect-of-crossover-the-case-of-pazopanib-in-advanced-renal-cell-carcinoma
#15
COMPARATIVE STUDY
Jose Diaz, Cora N Sternberg, Faisal Mehmud, Thomas E Delea, Nicholas Latimer, Lini Pandite, Robert J Motzer
OBJECTIVE: To identify the issues of using overall survival (OS) as a primary endpoint in the presence of crossover and the statistical analyses available to adjust for confounded OS due to crossover in oncology clinical trials. METHODS: An indirect comparison was conducted between pazopanib and sunitinib in advanced renal cell carcinoma. Statistical adjustment methods were used to estimate the true comparative effectiveness of these treatments. Recently, a head-to-head trial comparing pazopanib and sunitinib was completed...
2016: Oncology
https://www.readbyqxmd.com/read/26870952/muscle-logic-new-knowledge-resource-for-anatomy-enables-comprehensive-searches-of-the-literature-on-the-feeding-muscles-of-mammals
#16
Robert E Druzinsky, James P Balhoff, Alfred W Crompton, James Done, Rebecca Z German, Melissa A Haendel, Anthony Herrel, Susan W Herring, Hilmar Lapp, Paula M Mabee, Hans-Michael Muller, Christopher J Mungall, Paul W Sternberg, Kimberly Van Auken, Christopher J Vinyard, Susan H Williams, Christine E Wall
BACKGROUND: In recent years large bibliographic databases have made much of the published literature of biology available for searches. However, the capabilities of the search engines integrated into these databases for text-based bibliographic searches are limited. To enable searches that deliver the results expected by comparative anatomists, an underlying logical structure known as an ontology is required. DEVELOPMENT AND TESTING OF THE ONTOLOGY: Here we present the Mammalian Feeding Muscle Ontology (MFMO), a multi-species ontology focused on anatomical structures that participate in feeding and other oral/pharyngeal behaviors...
2016: PloS One
https://www.readbyqxmd.com/read/26228156/cometary-science-organic-compounds-on-comet-67p-churyumov-gerasimenko-revealed-by-cosac-mass-spectrometry
#17
Fred Goesmann, Helmut Rosenbauer, Jan Hendrik Bredehöft, Michel Cabane, Pascale Ehrenfreund, Thomas Gautier, Chaitanya Giri, Harald Krüger, Léna Le Roy, Alexandra J MacDermott, Susan McKenna-Lawlor, Uwe J Meierhenrich, Guillermo M Muñoz Caro, Francois Raulin, Reinhard Roll, Andrew Steele, Harald Steininger, Robert Sternberg, Cyril Szopa, Wolfram Thiemann, Stephan Ulamec
Comets harbor the most pristine material in our solar system in the form of ice, dust, silicates, and refractory organic material with some interstellar heritage. The evolved gas analyzer Cometary Sampling and Composition (COSAC) experiment aboard Rosetta's Philae lander was designed for in situ analysis of organic molecules on comet 67P/Churyumov-Gerasimenko. Twenty-five minutes after Philae's initial comet touchdown, the COSAC mass spectrometer took a spectrum in sniffing mode, which displayed a suite of 16 organic compounds, including many nitrogen-bearing species but no sulfur-bearing species, and four compounds—methyl isocyanate, acetone, propionaldehyde, and acetamide—that had not previously been reported in comets...
July 31, 2015: Science
https://www.readbyqxmd.com/read/26203561/conserved-nematode-signalling-molecules-elicit-plant-defenses-and-pathogen-resistance
#18
Patricia Manosalva, Murli Manohar, Stephan H von Reuss, Shiyan Chen, Aline Koch, Fatma Kaplan, Andrea Choe, Robert J Micikas, Xiaohong Wang, Karl-Heinz Kogel, Paul W Sternberg, Valerie M Williamson, Frank C Schroeder, Daniel F Klessig
Plant-defense responses are triggered by perception of conserved microbe-associated molecular patterns (MAMPs), for example, flagellin or peptidoglycan. However, it remained unknown whether plants can detect conserved molecular patterns derived from plant-parasitic animals, including nematodes. Here we show that several genera of plant-parasitic nematodes produce small molecules called ascarosides, an evolutionarily conserved family of nematode pheromones. Picomolar to micromolar concentrations of ascr#18, the major ascaroside in plant-parasitic nematodes, induce hallmark defense responses including the expression of genes associated with MAMP-triggered immunity, activation of mitogen-activated protein kinases, as well as salicylic acid- and jasmonic acid-mediated defense signalling pathways...
2015: Nature Communications
https://www.readbyqxmd.com/read/26185249/plant-ecology-worldwide-evidence-of-a-unimodal-relationship-between-productivity-and-plant-species-richness
#19
Lauchlan H Fraser, Jason Pither, Anke Jentsch, Marcelo Sternberg, Martin Zobel, Diana Askarizadeh, Sandor Bartha, Carl Beierkuhnlein, Jonathan A Bennett, Alex Bittel, Bazartseren Boldgiv, Ilsi I Boldrini, Edward Bork, Leslie Brown, Marcelo Cabido, James Cahill, Cameron N Carlyle, Giandiego Campetella, Stefano Chelli, Ofer Cohen, Anna-Maria Csergo, Sandra Díaz, Lucas Enrico, David Ensing, Alessandra Fidelis, Jason D Fridley, Bryan Foster, Heath Garris, Jacob R Goheen, Hugh A L Henry, Maria Hohn, Mohammad Hassan Jouri, John Klironomos, Kadri Koorem, Rachael Lawrence-Lodge, Ruijun Long, Pete Manning, Randall Mitchell, Mari Moora, Sandra C Müller, Carlos Nabinger, Kamal Naseri, Gerhard E Overbeck, Todd M Palmer, Sheena Parsons, Mari Pesek, Valério D Pillar, Robert M Pringle, Kathy Roccaforte, Amanda Schmidt, Zhanhuan Shang, Reinhold Stahlmann, Gisela C Stotz, Shu-ichi Sugiyama, Szilárd Szentes, Don Thompson, Radnaakhand Tungalag, Sainbileg Undrakhbold, Margaretha van Rooyen, Camilla Wellstein, J Bastow Wilson, Talita Zupo
The search for predictions of species diversity across environmental gradients has challenged ecologists for decades. The humped-back model (HBM) suggests that plant diversity peaks at intermediate productivity; at low productivity few species can tolerate the environmental stresses, and at high productivity a few highly competitive species dominate. Over time the HBM has become increasingly controversial, and recent studies claim to have refuted it. Here, by using data from coordinated surveys conducted throughout grasslands worldwide and comprising a wide range of site productivities, we provide evidence in support of the HBM pattern at both global and regional extents...
July 17, 2015: Science
https://www.readbyqxmd.com/read/26172499/-the-intelligence-of-nations-smart-but-not-wise-a-comment-on-hunt-2012
#20
Robert J Sternberg
I argue in this comment that Hunt's analysis of the intelligence of nations is smarter than it is wise. It is based on too narrow a conception of intelligence. It also conflates correlation and causation with regard to the relation between IQ and socially defined success, both individual and familial. I suggest that a better approach might be to compare nations as well for their creativity and wisdom.
March 2013: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
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