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icg breast cancer sln

Bin-Bin Cong, Xiao Sun, Xian-Rang Song, Yan-Bing Liu, Tong Zhao, Xiao-Shan Cao, Peng-Fei Qiu, Chong-Lin Tian, Jin-Ming Yu, Yong-Sheng Wang
An appropriate receptor-targeted tracer for sentinel lymph node biopsy (SLNB) was prepared. We combined the fluorescence tracer (Indocyanine green, ICG) with Rituximab (a chimeric human/murine monoclonal antibody targeting the CD20 antigen on the surface of lymphocyte) directly to produce a new tracer (ICG-Rituximab). When the new tracer drains to the lymph node, Rituximab will combine with CD20 receptor on the B-cell surface in the lymph node. If the statue of antibody-receptor connection does not reach saturation, the number of Rituximab is less than CD20...
June 21, 2016: Oncotarget
M-A Poumellec, M Dejode, A Figl, J Darcourt, J Haudebourg, Y Sabah, A Voury, A Martaens, E Barranger
OBJECTIVE: Assess the biopsy's feasibility of the sentinel lymph node biopsy (SLNB) using optonuclear probe after of indocyanine green (ICG) and radio-isotope (RI) injections. METHODS: Twenty-one patients with a localized breast cancer and unsuspicious axillary nodes underwent a SLNB after both injections of ICG and radio-isotope. RESULTS: One or more SLN were identified on the 21 patients (identification rate of 100%). The median number SLN was 2 (1-3)...
April 2016: Gynécologie, Obstétrique & Fertilité
M G Niebling, R G Pleijhuis, E Bastiaannet, A H Brouwers, G M van Dam, H J Hoekstra
PURPOSE: Sentinel lymph node biopsy (SLNB) has become a widely accepted staging procedure for both breast carcinoma and melanoma. The aim of our study was to systematically review different SLNB techniques and perform a meta-analysis for corresponding identification and false-negative rates. METHODS: A systematic review of the literature on SLNB in patients with early stage breast carcinoma and melanoma was performed. Only original study groups were included. The SLN identification rate and false negative rate were pooled for patients with breast carcinoma or melanoma according to radiocolloid tracer, blue dye, indocyanine green (ICG), or a combination of a radiocolloid tracer with blue dye or ICG...
April 2016: European Journal of Surgical Oncology
Tomoharu Sugie, Takayuki Kinoshita, Norikazu Masuda, Terumasa Sawada, Akira Yamauchi, Katsumasa Kuroi, Tetsuya Taguchi, Hiroko Bando, Hiroyasu Yamashiro, Tecchuu Lee, Nobuhiko Shinkura, Hironori Kato, Takafumi Ikeda, Kenichi Yoshimura, Hanae Ueyama, Masakazu Toi
PURPOSE: This study compared the clinical utility of indocyanine green (ICG) fluorescence and radioisotope (RI) for sentinel lymph node (SLN) detection in breast cancer. METHODS: Women with node-negative breast cancer underwent SLN biopsy using ICG fluorescence and RI. The primary end point was the sensitivity of ICG fluorescence compared with RI in the patients with tumor-positive SLNs. Secondary end points included detection rates for SLN, the additive effect of ICG fluorescence to RI, signature of positive SLNs according to tier, and adverse events related to ICG administration...
January 2016: Annals of Surgical Oncology
Shigeru Tsuyuki, Ayane Yamaguchi, Yukiko Kawata, Kosuke Kawaguchi
BACKGROUNDS: It is not clear how lymphatic pathways to the sentinel lymph node (SLN) change during neoadjuvant chemotherapy (NAC) for breast cancer. METHODS: Using the indocyanine green (ICG)-fluorescence method, we compared lymphatic pathways to the SLN (sentinel lymphatic pathways) and SLN location before and after NAC in 36 patients (38 breasts). RESULTS: Despite that 42.8% of the sentinel lymphatic pathways were changed by NAC, the locations of the SLNs were not affected by NAC...
June 2015: Breast: Official Journal of the European Society of Mastology
Tomoo Inoue, Toshio Nishi, Yoshiaki Nakano, Ayaka Nishimae, Yuka Sawai, Masaru Yamasaki, Hideo Inaji
BACKGROUND: There is limited information on indocyanine green (ICG) fluorescence and blue dye for detecting sentinel lymph node (SLN) in early breast cancer. A retrospective study was conducted to assess the feasibility of an SLN biopsy using the combination of ICG fluorescence and the blue dye method. METHODS: Seven hundred and fourteen patients with clinically node-negative breast cancer were included in this study. They underwent SLN biopsy using a combination of ICG fluorescence and the blue dye method from March 2007 to February 2014...
March 2016: Breast Cancer: the Journal of the Japanese Breast Cancer Society
Meng Tong, Wenbin Guo, Wei Gao
PURPOSE: Near-infrared fluorescence imaging with indocyanine green (ICG) has the potential to improve sentinel lymph node (SLN) mapping in breast cancer. In this clinical trial, we compared the potential value of ICG combined with blue dye with that of blue dye alone for detecting SLNs. METHODS: Patients undergoing SLN biopsy (SLNB) between November 2010 and November 2013 were included. Up to December 2011, SLNs were detected by using patent blue (PB) alone, and since January 2012, by using PB in combination with ICG...
September 2014: Journal of Breast Cancer
Wenbin Guo, Li Zhang, Jun Ji, Wei Gao, Jintao Liu, Meng Tong
BACKGROUND: Near infrared-guided indocyanine green (ICG) fluorescence has vast potential for guiding sentinel lymph node biopsy (SLNB) in patients with breast cancer. The purpose of this study was to evaluate any additional clinical benefit for SLNB when blue dye is used in combination with ICG. METHODS: Between November of 2009 and September of 2013, 86 patients diagnosed with breast cancer were investigated by SLNB using a combination of patent blue and ICG. A lymph node was considered as the sentinel lymph node (SLN) when it was stained with blue dye and/or fluorescence...
2014: World Journal of Surgical Oncology
Karol Polom, Dawid Murawa, Michał Michalak, Paweł Murawa
BACKGROUND: Sentinel node biopsy (SNB) is a gold standard in staging of early breast cancer. Nowadays, routine mapping of lymphatic tract is based on two tracers: human albumin with radioactive technetium, with or without blue dye. Recent years have seen a search for new tracers to examine sentinel node as well as lymphatic network. One of them is indocyanine green (ICG) visible in infrared light. AIM: The aim of this study is to evaluate clinical usage of ICG in comparison with standard tracer, i...
2011: Reports of Practical Oncology and Radiotherapy
Chongwei Chi, Jinzuo Ye, Haolong Ding, De He, Wenhe Huang, Guo-Jun Zhang, Jie Tian
Assessment of the sentinel lymph node (SLN) in patients with early stage breast cancer is vital in selecting the appropriate surgical approach. However, the existing methods, including methylene blue and nuclides, possess low efficiency and effectiveness in mapping SLNs, and to a certain extent exert side effects during application. Indocyanine green (ICG), as a fluorescent dye, has been proved reliable usage in SLN detection by several other groups. In this paper, we introduce a novel surgical navigation system to detect SLN with ICG...
2013: PloS One
Floris P R Verbeek, Susan L Troyan, J Sven D Mieog, Gerrit-Jan Liefers, Lorissa A Moffitt, Mireille Rosenberg, Judith Hirshfield-Bartek, Sylvain Gioux, Cornelis J H van de Velde, Alexander L Vahrmeijer, John V Frangioni
Near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) has the potential to improve the sentinel lymph node (SLN) procedure by facilitating percutaneous and intraoperative identification of lymphatic channels and SLNs. Previous studies suggested that a dose of 0.62 mg (1.6 mL of 0.5 mM) ICG is optimal for SLN mapping in breast cancer. The aim of this study was to evaluate the diagnostic accuracy of NIR fluorescence for SLN mapping in breast cancer patients when used in conjunction with conventional techniques...
January 2014: Breast Cancer Research and Treatment
Wenbin Guo, Li Zhang, Jun Ji, Wei Gao, Jintao Liu, Meng Tong
Near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) was considered to have the potential to improve sentinel lymph node (SLN) mapping in breast cancer. Herein, we performed a randomized clinical trial to evaluate the effectiveness of ICG fluorescence imaging compared with blue dye imaging in SLN navigation surgery. We also analyzed lymph drainage pathways to identify targets for sentinel lymph node biopsy (SLNB). Finally, 68 consecutive patients diagnosed with breast cancer and who underwent SLNB between November 2010 and September 2012 were enrolled in the study...
April 2014: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Tomoharu Sugie, Kassim Abdelazeem Kassim, Megumi Takeuchi, Takashi Hashimoto, Kazuhiko Yamagami, Yoshikazu Masai, Masakazu Toi
We investigated the feasibility of sentinel lymph node (SLN) biopsy using indocyanine green (ICG) technique in 411 patients with early breast cancer at three institutes. ICG, a fluorescence source, and blue dye were injected into the subareolar area to enable real-time image-guided surgery and identification of SLN fluorescence after meticulous dissection. The subcutaneous lymphatic channels were precisely detected in all cases. SLN identification rate was 99% (408/411) with a mean of 2.3 nodes identified per patient...
2010: Cancers
Shigeru Yamamoto, Noriko Maeda, Kiyoshi Yoshimura, Masaaki Oka
PURPOSE: This study aims to determine the utility of ultrasonography (US)-guided direct dye-marking of sentinel lymph nodes (SLNs) by real-time virtual sonography (RVS) constructed with three-dimensional (3D) computed tomography (CT)-lymphography (LG). PATIENTS AND METHODS: We identified SLNs in 258 clinically node-negative breast cancer patients using an RVS system to display in real time a virtual multiplanar reconstruction CT image obtained from CT volume data corresponding to the same cross-sectional image from US...
October 2013: Breast: Official Journal of the European Society of Mastology
B E Schaafsma, F P R Verbeek, D D D Rietbergen, B van der Hiel, J R van der Vorst, G J Liefers, J V Frangioni, C J H van de Velde, F W B van Leeuwen, A L Vahrmeijer
BACKGROUND: Combining radioactive colloids and a near-infrared (NIR) fluorophore permits preoperative planning and intraoperative localization of deeply located sentinel lymph nodes (SLNs) with direct optical guidance by a single lymphatic tracer. The aim of this clinical trial was to evaluate and optimize a hybrid NIR fluorescence and radioactive tracer for SLN detection in patients with breast cancer. METHODS: Patients with breast cancer undergoing SLN biopsy were enrolled...
July 2013: British Journal of Surgery
Tomoharu Sugie, Terumasa Sawada, Nobumi Tagaya, Takayuki Kinoshita, Kazuhiko Yamagami, Hirofumi Suwa, Takafumi Ikeda, Kenichi Yoshimura, Miyuki Niimi, Akira Shimizu, Masakazu Toi
PURPOSE: To assess the diagnostic performance of sentinel lymph node (SLN) biopsy using the indocyanine green (ICG) fluorescence method compared with that using the blue dye method, a prospective multicenter study was performed. METHODS: Patients with T1-3 primary breast cancer without clinical lymph node involvement were included in this study. ICG as a fluorescence-emitting source and indigo carmine as blue dye were injected into the subareolar area. Extracted lymph nodes were examined to identify the first, second, and other SLNs...
July 2013: Annals of Surgical Oncology
Jasung Koo, Mansik Jeon, Yunok Oh, Hyun Wook Kang, Jeehyun Kim, Chulhong Kim, Junghwan Oh
We demonstrate the feasibility of mapping a sentinel lymph node (SLN) and urinary bladder by using modified single-walled carbon nanotubes (SWNTs) as a nonionizing photoacoustic (PA) contrast agent. To improve the PA sensitivity, indocyanine green (ICG) was conjugated with SWNTs and the optical absorption of SWNTs-ICG was enhanced by approximately four times compared to that of plain SWNTs at a concentration of 0.3 µM. In vivo PA imaging results showed that the SLN and bladder were clearly visualized due to accumulation of SWNTs-ICG...
December 7, 2012: Physics in Medicine and Biology
Akira Hirano, Mari Kamimura, Kaoru Ogura, Naomi Kim, Akinori Hattori, Yumika Setoguchi, Fumie Okubo, Hiroaki Inoue, Reiko Miyamoto, Jun Kinoshita, Mariko Fujibayashi, Tadao Shimizu
PURPOSE: To evaluate two methods of sentinel node navigation surgery (SNNS) using blue dye with and without indocyanine green (ICG) fluorescence imaging (FI) to determine the usefulness of combined ICG and blue dye. METHODS: Between 2005 and 2010, a total of 501 patients underwent SNNS in our hospital. Detection of sentinel lymph node (SLN) was performed with sulfan blue (SB) alone until 2008 and with a combination of SB and ICG-FI since 2009. ICG 5 mg and SB 15 mg were injected in the subareolar region, and FI was obtained by a fluorescence imaging device...
December 2012: Annals of Surgical Oncology
Joost R van der Vorst, Boudewijn E Schaafsma, Floris P R Verbeek, Merlijn Hutteman, J Sven D Mieog, Clemens W G M Lowik, Gerrit-Jan Liefers, John V Frangioni, Cornelis J H van de Velde, Alexander L Vahrmeijer
BACKGROUND: Near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) has the potential to improve sentinel lymph node (SLN) mapping of breast cancer. We performed a randomized clinical trial to assess the value of blue dyes when used in combination with NIR fluorescence. We also preliminarily examined the possibility of performing SLN mapping without radiotracers. METHODS: Clinical trial subjects were 24 consecutive breast cancer patients scheduled to undergo SLN biopsy...
December 2012: Annals of Surgical Oncology
G C Wishart, S-W Loh, L Jones, J R Benson
BACKGROUND: There is now increasing evidence to support the use of indocyanine green (ICG) for sentinel lymph node (SLN) detection in early breast cancer. The primary objective of this feasibility study (ICG-10) was to determine the sensitivity and safety of ICG fluorescence imaging in sentinel lymph node identification when combined with blue dye and radiocolloid. METHODS: One hundred women with clinically node negative breast cancer (95 unilateral; 5 bilateral) had sentinel lymph node (SLN) biopsy using blue dye, radioisotope and ICG...
August 2012: European Journal of Surgical Oncology
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