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https://www.readbyqxmd.com/read/29149351/-medical-examination-preparation-for-ent-specialisation-part%C3%A2-33
#1
REVIEW
A Darbinjan, M Neudert
No abstract text is available yet for this article.
November 17, 2017: HNO
https://www.readbyqxmd.com/read/29145890/pharmacokinetic-study-of-single-and-multiple-dosing-with-metolazone-tablets-in-healthy-chinese-population
#2
Xueqing Li, Rutao Wang, Yang Liu, Yun Liu, Heng Zheng, Yabo Feng, Na Zhao, Hongbin Geng, Wanzhi Zhang, Aidong Wen
BACKGROUND: Metolazone is a diuretic, saluretic and antihypertensive chemical compound from the quinazoline category that possesses medicinal features similar to those of other thiazide diuretic drugs. However, the pharmacokinetics of metolazone in the Chinese population has rarely been studied. This study aimed to examine the pharmacokinetic characteristics, safety characteristic, and tolerability of metolazone in healthy Chinese subjects after single and multiple doses taken orally as well as the effects that food and gender have on oral metolazone pharmacokinetic parameters...
November 16, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29143322/certifying-death-in-the-united-states
#3
Leah Ruiz, Brianne M Posey, Melanie-Angela Neuilly, Mary K Stohr, Craig Hemmens
Accurately identifying death and its causes is integral to the compilation of mortality data and ultimately to the operation of the criminal justice and public health systems. A clear understanding of who is in charge of such processes is paramount to establishing the quality, or lack thereof, of the information provided in death certificates. Our study provides a comprehensive overview of all state statutes identifying death investigators charged with classifying and certifying death in the United States. We found that state statutes designate a broad range of individuals as responsible for the classification and certification of death...
November 16, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29141602/association-between-sarcopenia-and-low-back-pain-in-local-residents-prospective-cohort-study-from-the-gaina-study
#4
Shinji Tanishima, Hiroshi Hagino, Hiromi Matsumoto, Chika Tanimura, Hideki Nagashima
BACKGROUND: Low back pain (LBP) is one of the most common ailments that people experience in their lifetime. On the other hands, Sarcopenia also leads to several physical symptoms and contributes to reducing the quality of life of elderly people.The purpose of this study is to investigate the association between sarcopenia and low back pain among the general population. METHODS: The subjects included 216 adults (79 men and 137 women; mean age, 73.5 years) undergoing a general medical examination in Hino, Japan...
November 15, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29133596/exposure-to-ambient-fine-particulate-matter-and-semen-quality-in-taiwan
#5
Xiang Qian Lao, Zilong Zhang, Alexis Kh Lau, Ta-Chien Chan, Yuan Chieh Chuang, Jimmy Chan, Changqing Lin, Cui Guo, Wun Kai Jiang, Tony Tam, Gerard Hoek, Haidong Kan, Eng-Kiong Yeoh, Ly-Yun Chang
OBJECTIVES: Environmental exposure to chemicals has been considered a potential factor contributing to deteriorated semen quality. However, previous literature on exposure to air pollution and semen quality is inconsistent. We therefore investigated the health effects of short-term and long-term exposure to fine particulate matter (PM2.5) on semen quality in Taiwanese men from the general population. METHODS: A cross-sectional study was conducted among 6475 male participants aged 15-49 years who participated in a standard medical examination programme in Taiwan between 2001 and 2014...
November 13, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29130236/-occurrence-diagnosis-and-treatment-of-de-novo-gastrointestinal-malignancies-after-organ-transplantation
#6
Linhua Ji, Gang Zhao
With the continuous use of immunosuppressive agents routinely, the long-term survival rate of organ transplant recipients has been incessantly improved. However, the risk of de novo malignancies is also increasing, which has become the second cause of death after organ transplantation. De novo gastrointestinal malignancies are common after liver or kidney transplantation, mostly with advanced stage when diagnosed and poor prognosis. There is a significant trend in the development of de novo malignancies in transplant recipients, which is probably related to factors, including direct or indirect effects of immunosuppressive agents, precancerosis and survival time of transplanted grafts and recipients...
October 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29123931/rapid-ascending-sensorimotor-paralysis-hearing-loss-and-fatal-arrhythmia-in-a-multimorbid-patient-due-to-an-accidental-overdose-of-fluoxetine
#7
Matthew Herrmann, Prissilla Xu, Antonio Liu
Background: Common side effects of selective serotonin reuptake inhibitors (SSRIs) include tachycardia, drowsiness, tremor, nausea, and vomiting. Although SSRIs have less toxic side effects compared to more traditional antidepressants, serious and life threatening cases of SSRI overdose have been reported. We describe a 24-year-old multimorbid female who presented to the emergency department with rapid onset ascending sensorimotor paralysis, complicated by respiratory and cardiac arrest, found to have fatal levels of fluoxetine by toxicological analysis, not taken in a suicidal act...
2017: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/29123875/indications-of-early-intubation-for-patients-with-inhalation-injury
#8
Shinya Onishi, Akinori Osuka, Yuichi Kuroki, Masashi Ueyama
Aim: For patients with inhalation injury, the indications for early intubation are diverse. The purpose of this study was to identify the most reliable symptoms, physical findings, and medical examinations with which to determine the indications for early intubation in patients with inhalation injury. Methods: We retrospectively collected patient data from medical records. Collected data included age, sex, burn size, symptoms, physical findings, carboxyhemoglobin levels (COHb), and bronchial wall thickness (BWT) determined from chest computed tomography images...
July 2017: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29119548/association-of-total-cholesterol-low-density-lipoprotein-cholesterol-and-non-high-density-lipoprotein-cholesterol-with-atherosclerotic-cardiovascular-disease-and-cancer-in-a-chinese-male-population
#9
Xu-Min Guan, Shou-Ling Wu, Xiao-Lei Yang, Xu Han, Yi-Heng Yang, Xin-Tao Li, BinWaleed Khalid, Yue Du, Si-Yan Zhan, Ying Liu, Hui-Hua Li, Yun-Long Xia
Objective The objective of this study was to investigate the association between total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and non-high-density lipoprotein cholesterol (non-HDL-C) with atherosclerotic cardiovascular disease (ASCVD) or cancer in a male population in the Kailuan cohort of China. Methods This prospective study included 68,769 Chinese male adults from Kailuan cohort of China who had a standardized medical examination between 2006 and 2007 and were followed up for approximately 8 years until occurrence of ASCVD, cancer or death or until December 31, 2014...
November 9, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29114718/ascertainment-of-self-reported-prescription-medication-use-compared-with-pharmaceutical-claims-data
#10
Danijela Gnjidic, Wei Du, Sallie-Anne Pearson, Sarah N Hilmer, Emily Banks
BACKGROUND: Evidence on the comparative validity of self-reported medication use in large-scale studies is limited. This study compared self-reported medication use of prescription-only medications to gold standard pharmaceutical claims (i.e. dispensing) data. METHODS: We selected a random sample of 500 participants from the 45 and Up Study, a large-scale Australian study, with complete ascertainment of Pharmaceutical Benefits Scheme dispensing records. Self-reported medication use was ascertained by questionnaire requesting data on medications used "for most of the last 4 weeks"...
October 11, 2017: Public Health Research & Practice
https://www.readbyqxmd.com/read/29108003/schistosoma-other-helminth-infections-and-associated-risk-factors-in-preschool-aged-children-in-urban-tanzania
#11
Khadija Said, Jerry Hella, Stefanie Knopp, Tatu Nassoro, Neema Shija, Fatma Aziz, Francis Mhimbira, Christian Schindler, Upendo Mwingira, Anna M Mandalakas, Karim Manji, Marcel Tanner, Jürg Utzinger, Lukas Fenner
BACKGROUND: Despite the high prevalence of helminth infections among preschool-aged children, control programs in sub-Saharan countries primarily focus on school-aged populations. We assessed the prevalence of helminth infections and determined risk factors for infection among preschool-aged children in the urban setting of Dar es Salaam, Tanzania. METHODOLOGY: Starting in October 2015, we conducted a 12-month prospective study among tuberculosis (TB)-exposed children under the age of 5 years and unexposed controls from neighboring households...
November 6, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29101892/performance-evaluation-of-a-mitogenome-capture-and-illumina-sequencing-protocol-using-non-probative-case-type-skeletal-samples-implications-for-the-use-of-a-positive-control-in-a-next-generation-sequencing-procedure
#12
Charla Marshall, Kimberly Sturk-Andreaggi, Jennifer Daniels-Higginbotham, Robert Sean Oliver, Suzanne Barritt-Ross, Timothy P McMahon
Next-generation ancient DNA technologies have the potential to assist in the analysis of degraded DNA extracted from forensic specimens. Mitochondrial genome (mitogenome) sequencing, specifically, may be of benefit to samples that fail to yield forensically relevant genetic information using conventional PCR-based techniques. This report summarizes the Armed Forces Medical Examiner System's Armed Forces DNA Identification Laboratory's (AFMES-AFDIL) performance evaluation of a Next-Generation Sequencing protocol for degraded and chemically treated past accounting samples...
September 8, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/29101746/quantitative-target-proteomics-of-chromosome-13-human-blood-plasma-proteins
#13
A T Kopylov, E V Ilgisonis, O V Tikhonova, T E Farafonova, S E Novikova, V G Zgoda, E A Ponomarenko, A V Lisitsa, A A Markin, B V Morukov, A I Grigoriev, A I Archakov
Quantitative proteomic analysis of 50 blood plasma samples of healthy volunteers who underwent a comprehensive medical examination and were found eligible for space flights was performed. As a result of directed mass spectrometric analysis, signals for 128 proteins, which accounted for nearly 40% of the total number of chromosome 13 gene products, were detected. The analysis of interindividual variation of concentrations of chromosome 13 proteins showed the presence of a pool comprising 41 proteins with a low variation (CV < 30%), which can potentially be used as biomarkers...
September 2017: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29097625/autoantibodies-against-at1-and-%C3%AE-1-adrenergic-receptors-predict-arterial-stiffness-progression-in-normotensive-subjects-over-a-5-year-period
#14
Gang Li, Zhe Cao, Xiao-Wei Wu, Hui-Kun Wu, Yi Ma, Bin Wu, Wei-Qing Wang, Jian Cheng, Zi-Hua Zhou, Yuan-Chao Tu
Objective: Arterial stiffness is an independent indicator of cardiovascular risk. Autoantibodies (AAs) against angiotensin AT1 receptor (AT1-AAs) and α1-Adrenergic receptor (α1-AAs) are important in the pathogenesis of hypertension. We identified the types of AT1-AAs and α1-AAs in normotensive subjects, with the aim of determining whether these antibodies predict aortic stiffness progression. Methods: Carotid-femoral pulse wave velocity (cf-PWV) was used to measure aortic stiffness. Overall, 816 subjects (71% of those invited) underwent a medical examination and evaluation of aortic stiffness...
November 2, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29091542/death-certification-errors-and-the-effect-on-mortality-statistics
#15
Lauri McGivern, Leanne Shulman, Jan K Carney, Steven Shapiro, Elizabeth Bundock
OBJECTIVE: Errors in cause and manner of death on death certificates are common and affect families, mortality statistics, and public health research. The primary objective of this study was to characterize errors in the cause and manner of death on death certificates completed by non-Medical Examiners. A secondary objective was to determine the effects of errors on national mortality statistics. METHODS: We retrospectively compared 601 death certificates completed between July 1, 2015, and January 31, 2016, from the Vermont Electronic Death Registration System with clinical summaries from medical records...
November 2017: Public Health Reports
https://www.readbyqxmd.com/read/29090334/social-vulnerabilities-and-health-conditions-of-arrestees-in-the-greater-paris-area-france-in-2013-a-multicentre-cross-sectional-study
#16
Emilie Verdier, Céline Denis, Nacer Bourokba, Pierre Chauvin, Patrick Chariot
OBJECTIVE: The aim of this study was to describe the health and social conditions of arrestees, as compared to the general population. METHODS: We studied a sample of 600 adult arrestees in three locations in the Greater Paris area, prospectively included (February-May 2013). A descriptive analysis has been performed, then prevalence was estimated using an indirect standardisation according to age, based on data from a population-based, representative survey in the same area...
October 31, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29080523/fatal-poisonings-involving-propoxyphene-before-and-after-voluntary-withdrawal-from-the-united-states-market-an-analysis-from-the-state-of-florida
#17
Chris Delcher, Guanming Chen, Yanning Wang, Svetla Slavova, Bruce A Goldberger
The synthetic opioid propoxyphene was a schedule IV controlled substance with multiple reported health risks before the US Food and Drug Administration issued a request for voluntary market withdrawal in November 2010. The purpose of this study is to investigate the characteristics and occurrences of propoxyphene-related deaths in Florida before and after voluntary market removal. Decedent-level toxicology data from Florida's Medical Examiners Commission was used to compare the temporal, polysubstance use, sociodemographic, and geographic profiles associated with propoxyphene-involved deaths for a pre-withdrawal (November 2008-November 2010) and post-withdrawal (December 2010-December 2012) period...
October 14, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29080494/aqme-a-forensic-mitochondrial-dna-analysis-tool-for-next-generation-sequencing-data
#18
Kimberly Sturk-Andreaggi, Michelle A Peck, Cecilie Boysen, Patrick Dekker, Timothy P McMahon, Charla K Marshall
The feasibility of generating mitochondrial DNA (mtDNA) data has expanded considerably with the advent of next-generation sequencing (NGS), specifically in the generation of entire mtDNA genome (mitogenome) sequences. However, the analysis of these data has emerged as the greatest challenge to implementation in forensics. To address this need, a custom toolkit for use in the CLC Genomics Workbench (QIAGEN, Hilden, Germany) was developed through a collaborative effort between the Armed Forces Medical Examiner System - Armed Forces DNA Identification Laboratory (AFMES-AFDIL) and QIAGEN Bioinformatics...
September 19, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/29065740/budget-impact-analysis-on-the-introduction-of-a-guideline-based-hepatitis-b-and-c-screening-into-a-routine-check-up-in-the-german-primary-care-setting
#19
Cordula Barth, Silke Neusser, Janine Biermann, Jürgen Wasem, Thomas Berg, Johannes Wiegand, Ingmar Wolffram, David Petroff, Pamela Aidelsburger, Alexandra Grünbauer, Anja Neumann
OBJECTIVES: Systematic screening for chronic hepatitis B and C does not yet exist in Germany. Therefore, the implementation of a screening approach within a preventive medical examination performed by primary care physicians ('Check-Up 35+') was evaluated in a recent prospective multicenter study. The present analysis estimates the financial consequences for the statutory health insurance by budget impact analysis. MATERIALS AND METHODS: A Markov cohort model was developed consisting of 21 health states...
October 24, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29065019/formative-assessment-in-an-integrated-curriculum-identifying-at-risk-students-for-poor-performance-on-usmle-step-1-using-nbme-custom-exam-questions
#20
Judith M Brenner, Jeffrey B Bird, Joanne M Willey
PURPOSE: The Hofstra Northwell School of Medicine (HNSOM) uses an essay-based assessment system. Recognizing the emphasis graduate medical education places on the United States Medical Licensing Examination (USMLE) Step exams, the authors developed a method to predict students at risk for lower performance on USMLE Step 1. METHOD: Beginning with the inaugural class (2015), HNSOM administered National Board of Medical Examiners (NBME) Customized Assessment Service (CAS) examinations as formative assessment at the end of each integrated course in the first two years of medical school...
November 2017: Academic Medicine: Journal of the Association of American Medical Colleges
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