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Andrew Pearle

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https://www.readbyqxmd.com/read/28628728/characterizing-the-detection-threshold-for-optical-imaging-in-surgical-oncology
#1
Andrew C Prince, Aditi Jani, Melissa Korb, Kiranya E Tipirneni, Benjamin B Kasten, Eben L Rosenthal, Jason M Warram
BACKGROUND AND OBJECTIVES: Optical imaging to guide cancer resections is rapidly transitioning into the operating room. However, the sensitivity of this technique to detect subclinical disease is yet characterized. The purpose of this study was to determine the minimum range of cancer cells that can be detected by antibody-based fluorescence imaging. METHODS: 2LMP (breast), COLO-205 (colon), MiaPaca-2 (pancreas), and SCC-1 (head and neck) cells incubated in vitro with cetuximab-IRDye800CW (dose range 8...
June 19, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28601764/maternal-perchlorate-exposure-in-pregnancy-and-altered-birth-outcomes
#2
Rainbow Rubin, Michelle Pearl, Martin Kharrazi, Benjamin C Blount, Mark D Miller, Elizabeth N Pearce, Liza Valentin-Blasini, Gerald DeLorenze, Jane Liaw, Andrew N Hoofnagle, Craig Steinmaus
BACKGROUND: At high medicinal doses perchlorate is known to decrease the production of thyroid hormone, a critical factor for fetal development. In a large and uniquely exposed cohort of pregnant women, we recently identified associations between environmental perchlorate exposures and decreased maternal thyroid hormone during pregnancy. Here, we investigate whether perchlorate might be associated with birthweight or preterm birth in the offspring of these women. METHODS: Maternal urinary perchlorate, serum thyroid hormone concentrations, birthweight, gestational age, and urinary nitrate, thiocyanate, and iodide were collected in 1957 mother-infant pairs from San Diego County during 2000-2003, a period when the county's water supply was contaminated with perchlorate...
June 8, 2017: Environmental Research
https://www.readbyqxmd.com/read/28592667/motorboat-noise-impacts-parental-behaviour-and-offspring-survival-in-a-reef-fish
#3
Sophie L Nedelec, Andrew N Radford, Leanne Pearl, Brendan Nedelec, Mark I McCormick, Mark G Meekan, Stephen D Simpson
Anthropogenic noise is a pollutant of international concern, with mounting evidence of disturbance and impacts on animal behaviour and physiology. However, empirical studies measuring survival consequences are rare. We use a field experiment to investigate how repeated motorboat-noise playback affects parental behaviour and offspring survival in the spiny chromis (Acanthochromis polyacanthus), a brooding coral reef fish. Repeated observations were made for 12 days at 38 natural nests with broods of young. Exposure to motorboat-noise playback compared to ambient-sound playback increased defensive acts, and reduced both feeding and offspring interactions by brood-guarding males...
June 14, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28523513/erratum-to-high-interspecimen-variability-in-engagement-of-the-anterolateral-ligament-an-in-vitro-cadaveric-study
#4
Robert N Kent, James F Boorman-Padgett, Ran Thein, Jelle P van der List, Danyal H Nawabi, Thomas L Wickiewicz, Carl W Imhauser, Andrew D Pearle
No abstract text is available yet for this article.
May 18, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28477147/high-interspecimen-variability-in-engagement-of-the-anterolateral-ligament-an-in-vitro-cadaveric-study
#5
REVIEW
Robert N Kent, James F Boorman-Padgett, Ran Thein, Jelle P van der List, Danyal H Nawabi, Thomas L Wickiewicz, Carl W Imhauser, Andrew D Pearle
BACKGROUND: Anterolateral ligament (ALL) reconstruction as an adjunct to anterior cruciate ligament (ACL) reconstruction remains a subject of clinical debate. This uncertainty may be driven in part by a lack of knowledge regarding where, within the range of knee motion, the ALL begins to carry force (engages). QUESTIONS/PURPOSES: (1) Does the ALL engage in the ACL-intact knee; and (2) where within the range of anterior tibial translation occurring in the ACL-sectioned knee does the ALL engage? METHODS: A robotic manipulator was used to measure anterior tibial translation, ACL forces, and ALL forces in 10 fresh-frozen cadaveric knees (10 donors; mean age, 41 ± 16 years; range, 20-64 years; eight male) in response to applied multiplanar torques...
May 5, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28435507/blog-and-podcast-watch-orthopedic-emergencies
#6
Andrew Grock, Salim Rezaie, Anand Swaminathan, Alice Min, Kaushal H Shah, Michelle Lin
INTRODUCTION: The WestJEM Blog and Podcast Watch presents high quality open-access educational blogs and podcasts in emergency medicine (EM) based on the ongoing ALiEM Approved Instructional Resources (AIR) and AIR-Professional series. Both series critically appraise resources using an objective scoring rubric. This installment of the Blog and Podcast Watch highlights the topic of orthopedic emergencies from the AIR series. METHODS: The AIR series is a continuously building curriculum that follows the Council of Emergency Medicine Residency Directors (CORD) annual testing schedule...
April 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28409106/open-bankart-revisited
#7
Ryan P Coughlin, Andrew Crapser, Kyrstin Coughlin, Larry P Coughlin
The surgical treatment of anterior shoulder instability can present a dilemma. Historically, an open Bankart repair was the benchmark solution. Over the last decade as surgeons became more arthroscopically savvy, the pendulum swung and a paradigm shift occurred. However, more recent studies have challenged this trend and, subsequently, revived interest in open repair. Thus, we feel it is critical to provide a more contemporary stepwise description of a procedure that has become essentially abandoned. The goal is to provide tips and pearls to achieve optimal exposure and, ultimately, a robust repair for a notoriously challenging operation...
February 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28355672/ligamentous-reconstruction-of-the-knee-what-orthopaedic-surgeons-want-radiologists-to-know
#8
Andrew G Geeslin, Matthew G Geeslin, Robert F LaPrade
Knee ligament injuries are common, and treatment methods are continually evolving. Accurate clinical diagnosis with imaging confirmation is critical to support appropriate treatment. Several imaging pearls allow for improved recognition of injuries. Stress radiographs may be obtained to quantify knee laxity. Magnetic resonance imaging allows assessment of the complex anatomy of the knee and has excellent sensitivity and specificity for many injuries.
April 2017: Seminars in Musculoskeletal Radiology
https://www.readbyqxmd.com/read/28355083/systematic-review-of-outcomes-reporting-in-professional-baseball-a-call-for-increased-validation-and-consistency
#9
Jelle P van der List, Christopher L Camp, Alec L Sinatro, Joshua S Dines, Andrew D Pearle
BACKGROUND: Historically, treatment efficacy of professional baseball injuries has been determined by assessing the return-to-play (RTP) rate or using patient-reported functional outcomes scores; however, these methods may not be sensitive and specific enough for elite athletes. As a consequence, performance-based statistics are increasingly being reported in the medical literature. PURPOSE: To (1) assess how treatment efficacy is currently reported in professional baseball players; (2) examine the variability in the reporting of these measures in terms of frequency, length of time followed, and units of measure; and (3) identify any attempts to validate these performance-based statistics...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28298053/passive-anterior-tibial-subluxation-in-the-setting-of-anterior-cruciate-ligament-injuries-a-comparative-analysis-of-ligament-deficient-states
#10
Lucas S McDonald, Jelle P van der List, Kristofer J Jones, Hendrik A Zuiderbaan, Joseph T Nguyen, Hollis G Potter, Andrew D Pearle
BACKGROUND: Static anterior tibial subluxation after an anterior cruciate ligament (ACL) injury highlights the abnormal relationship between the tibia and femur in patients with ACL insufficiency, although causal factors including injuries to secondary stabilizers or the time from injury to reconstruction have not been examined. PURPOSE: To determine static relationships between the tibia and femur in patients with various states of ACL deficiency and to identify factors associated with anterior tibial subluxation...
June 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28210366/blog-and-podcast-watch-cutaneous-emergencies
#11
Andrew Grock, Eric J Morley, Lynn Roppolo, Jay Khadpe, Felix Ankel, Michelle Lin
INTRODUCTION: The WestJEM Blog and Podcast Watch presents high quality open-access educational blogs and podcasts in emergency medicine (EM) based on the ongoing Academic Life in Emergency Medicine (ALiEM) Approved Instructional Resources (AIR) and AIR-Professional series. Both series critically appraise resources using an objective scoring rubric. This installment of the Blog and Podcast Watch highlights the topic of cutaneous emergencies from the AIR series. METHODS: The AIR series is a continuously building curriculum that follows the Council of Emergency Medicine Residency Directors (CORD) annual testing schedule...
February 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28185777/survivorship-and-patient-satisfaction-of-robotic-assisted-medial-unicompartmental-knee-arthroplasty-at-a-minimum-two-year-follow-up
#12
Andrew D Pearle, Jelle P van der List, Lily Lee, Thomas M Coon, Todd A Borus, Martin W Roche
BACKGROUND: Successful clinical outcomes following unicompartmental knee arthroplasty (UKA) depend on lower limb alignment, soft tissue balance and component positioning, which can be difficult to control using manual instrumentation. Although robotic-assisted surgery more reliably controls these surgical factors, studies assessing outcomes of robotic-assisted UKA are lacking. Therefore, a prospective multicenter study was performed to assess outcomes of robotic-assisted UKA. METHODS: A total of 1007 consecutive patients (1135 knees) underwent robotic-assisted medial UKA surgery from six surgeons at separate institutions between March 2009 and December 2011...
February 6, 2017: Knee
https://www.readbyqxmd.com/read/28086751/quantifying-predictors-for-the-spatial-diffusion-of-avian-influenza-virus-in-china
#13
Lu Lu, Andrew J Leigh Brown, Samantha J Lycett
BACKGROUND: Avian influenza virus (AIV) causes both severe outbreaks and endemic disease among poultry and has caused sporadic human infections in Asia, furthermore the routes of transmission in avian species between geographic regions can be numerous and complex. Using nucleotide sequences from the internal protein coding segments of AIV, we performed a Bayesian phylogeographic study to uncover regional routes of transmission and factors predictive of the rate of viral diffusion within China...
January 13, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28005121/limited-incision-knotless-achilles-tendon-repair
#14
Andrew R Hsu
Acute midsubstance Achilles tendon ruptures, which are increasingly common among athletes, can result in significant functional limitations and decreased quality of life when not managed appropriately. The various surgical techniques for treating Achilles ruptures include open repair with Krackow locking sutures, percutaneous repair, and limited-incision repair with suture-passing jigs. Less invasive techniques have been developed to optimize the functional benefits of surgery while reducing delayed wound healing, infection, and other postoperative complications...
November 2016: American Journal of Orthopedics
https://www.readbyqxmd.com/read/28005097/why-do-lateral-unicompartmental-knee-arthroplasties-fail-today
#15
REVIEW
Jelle P van der List, Hendrik A Zuiderbaan, Andrew D Pearle
In large studies, the failure modes of lateral unicompartmental knee arthroplasty (UKA) are usually presented in combination with medial UKA, which is mainly due to low surgical frequency of lateral UKA. Because lateral UKA differs from medial UKA in anatomic and kinematic characteristics, failure modes of lateral UKA should not be presented in combination with medial UKA. Therefore, we performed a systematic review to assess failure modes in lateral UKA and compared failure modes in cohort studies with those found in registry-based studies...
November 2016: American Journal of Orthopedics
https://www.readbyqxmd.com/read/27992199/contribution-of-shape-and-charge-to-the-inhibition-of-a-family-gh99-endo-%C3%AE-1-2-mannanase
#16
Marija Petricevic, Lukasz F Sobala, Pearl Z Fernandes, Lluís Raich, Andrew J Thompson, Ganeko Bernardo-Seisdedos, Oscar Millet, Sha Zhu, Matthieu Sollogoub, Jesús Jiménez-Barbero, Carme Rovira, Gideon J Davies, Spencer J Williams
Inhibitor design incorporating features of the reaction coordinate and transition-state structure has emerged as a powerful approach for the development of enzyme inhibitors. Such inhibitors find use as mechanistic probes, chemical biology tools, and therapeutics. Endo-α-1,2-mannosidases and endo-α-1,2-mannanases, members of glycoside hydrolase family 99 (GH99), are interesting targets for inhibitor development as they play key roles in N-glycan maturation and microbiotal yeast mannan degradation, respectively...
January 25, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27984454/nonunion-after-clavicle-osteosynthesis-high-incidence-of-propionibacterium-acnes
#17
Elizabeth B Gausden, Jordan Villa, Stephen J Warner, Mariya Redko, Andrew Pearle, Andy Miller, Michael Henry, Dean G Lorich, David L Helfet, David S Wellman
OBJECTIVE: The objective of this study was to review the etiology of clavicle nonunions after osteosynthesis and investigate the outcomes of a treatment with a single-stage revision. DESIGN: Retrospective case series. SETTING: Orthopaedic specialty hospital. PATIENTS: Twenty cases of nonunion after osteosynthesis of the clavicle were identified. The average age was 44 years (±13 years). In 9 cases, there was catastrophic implant failure that prompted the revision surgery...
April 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/27959878/exploring-the-relationships-between-small-non-community-drinking-water-system-characteristics-and-water-system-performance-in-ontario-canada
#18
Wendy Pons, Ian Young, David Pearl, Andria Jones-Bitton, Scott A McEwen, Katarina Pintar, Andrew Papadopoulos
The objectives of this work were to investigate the relationships between characteristics of small non-community drinking water systems (SDWSs) and the performance of these systems with respect to Escherichia coli testing and risk ratings. Ontario-wide SDWS data were analysed using regression models with outcomes of (1) having an adverse E. coli test result in the 12 months prior to the last inspection and (2) the SDWS risk rating (high/medium vs. low risk) that is assigned by public health inspectors. Almost 34% (2,364/7,003) of SDWSs did not utilize treatment, more commonly for ground water than surface supplies (P < 0...
December 2016: Journal of Water and Health
https://www.readbyqxmd.com/read/27923627/outcomes-of-cementless-unicompartmental-and-total-knee-arthroplasty-a-systematic-review
#19
REVIEW
Jelle P van der List, Dana L Sheng, Laura J Kleeblad, Harshvardhan Chawla, Andrew D Pearle
BACKGROUND: Aseptic loosening is a common failure mode in cemented unicompartmental knee arthroplasty (UKA) and total knee arthroplasty (TKA). This led to the development of cementless designs but the historical outcomes were poor. Recent developments in cementless designs have improved outcomes, but the current status is unknown. Therefore, a systematic review was performed to assess recent outcomes of cementless knee arthroplasty. METHODS: A search was performed using PubMed, Embase and Cochrane systems and national registries for studies reporting outcomes since 2005...
December 3, 2016: Knee
https://www.readbyqxmd.com/read/27916580/annual-revision-rates-of-partial-versus-total-knee-arthroplasty-a-comparative-meta-analysis
#20
REVIEW
Harshvardhan Chawla, Jelle P van der List, Alexander B Christ, Maximiliano R Sobrero, Hendrik A Zuiderbaan, Andrew D Pearle
BACKGROUND: Utilization of unicompartmental knee arthroplasty (UKA) and patellofemoral arthroplasty (PFA) as alternatives to total knee arthroplasty (TKA) for unicompartmental knee osteoarthritis (OA) has increased. However, no single resource consolidates survivorship data between TKA and partial resurfacing options for each variant of unicompartmental OA. This meta-analysis compared survivorship between TKA and medial UKA (MUKA), lateral UKA (LUKA) and PFA using annual revision rate as a standardized metric...
December 1, 2016: Knee
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