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Andrew Pearle

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https://www.readbyqxmd.com/read/28086751/quantifying-predictors-for-the-spatial-diffusion-of-avian-influenza-virus-in-china
#1
Lu Lu, Andrew J Leigh Brown, Samantha J Lycett
BACKGROUND: Avian influenza virus (AIV) causes both severe outbreaks and endemic disease among poultry and has caused sporadic human infections in Asia, furthermore the routes of transmission in avian species between geographic regions can be numerous and complex. Using nucleotide sequences from the internal protein coding segments of AIV, we performed a Bayesian phylogeographic study to uncover regional routes of transmission and factors predictive of the rate of viral diffusion within China...
January 13, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28005121/limited-incision-knotless-achilles-tendon-repair
#2
Andrew R Hsu
Acute midsubstance Achilles tendon ruptures, which are increasingly common among athletes, can result in significant functional limitations and decreased quality of life when not managed appropriately. The various surgical techniques for treating Achilles ruptures include open repair with Krackow locking sutures, percutaneous repair, and limited-incision repair with suture-passing jigs. Less invasive techniques have been developed to optimize the functional benefits of surgery while reducing delayed wound healing, infection, and other postoperative complications...
November 2016: American Journal of Orthopedics
https://www.readbyqxmd.com/read/28005097/why-do-lateral-unicompartmental-knee-arthroplasties-fail-today
#3
Jelle P van der List, Hendrik A Zuiderbaan, Andrew D Pearle
In large studies, the failure modes of lateral unicompartmental knee arthroplasty (UKA) are usually presented in combination with medial UKA, which is mainly due to low surgical frequency of lateral UKA. Because lateral UKA differs from medial UKA in anatomic and kinematic characteristics, failure modes of lateral UKA should not be presented in combination with medial UKA. Therefore, we performed a systematic review to assess failure modes in lateral UKA and compared failure modes in cohort studies with those found in registry-based studies...
November 2016: American Journal of Orthopedics
https://www.readbyqxmd.com/read/27992199/contribution-of-shape-and-charge-to-the-inhibition-of-a-family-gh99-endo-%C3%AE-1-2-mannanase
#4
Marija Petricevic, Lukasz F Sobala, Pearl Z Fernandes, Lluís Raich, Andrew J Thompson, Ganeko Bernardo-Seisdedos, Oscar Millet, Sha Zhu, Matthieu Sollogoub, Jesús Jiménez-Barbero, Carme Rovira, Gideon J Davies, Spencer J Williams
Inhibitor design incorporating features of the reaction coordinate and transition-state structure has emerged as a powerful approach for the development of enzyme inhibitors. Such inhibitors find use as mechanistic probes, chemical biology tools, and therapeutics. Endo-α-1,2-mannosidases and endo-α-1,2-mannanases, members of glycoside hydrolase family 99 (GH99), are interesting targets for inhibitor development as they play key roles in N-glycan maturation and microbiotal yeast mannan degradation, respectively...
January 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27984454/nonunion-after-clavicle-osteosynthesis-high-incidence-of-propionibacterium-acnes
#5
Elizabeth B Gausden, Jordan Villa, Stephen J Warner, Mariya Redko, Andrew Pearle, Andy Miller, Michael Henry, Dean G Lorich, David L Helfet, David S Wellman
OBJECTIVE: The objective of this study was to review the etiology of clavicle nonunions following osteosynthesis and investigate the outcomes of a treatment with a single stage revision. DESIGN: Retrospective case series SETTING:: Orthopaedic specialty hospital PATIENTS:: Twenty cases of nonunion following osteosynthesis of the clavicle were identified. The average age was 44 years old (+/- 13 years). In nine cases there was catastrophic implant failure that prompted the revision surgery...
December 8, 2016: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/27959878/exploring-the-relationships-between-small-non-community-drinking-water-system-characteristics-and-water-system-performance-in-ontario-canada
#6
Wendy Pons, Ian Young, David Pearl, Andria Jones-Bitton, Scott A McEwen, Katarina Pintar, Andrew Papadopoulos
The objectives of this work were to investigate the relationships between characteristics of small non-community drinking water systems (SDWSs) and the performance of these systems with respect to Escherichia coli testing and risk ratings. Ontario-wide SDWS data were analysed using regression models with outcomes of (1) having an adverse E. coli test result in the 12 months prior to the last inspection and (2) the SDWS risk rating (high/medium vs. low risk) that is assigned by public health inspectors. Almost 34% (2,364/7,003) of SDWSs did not utilize treatment, more commonly for ground water than surface supplies (P < 0...
December 2016: Journal of Water and Health
https://www.readbyqxmd.com/read/27923627/outcomes-of-cementless-unicompartmental-and-total-knee-arthroplasty-a-systematic-review
#7
REVIEW
Jelle P van der List, Dana L Sheng, Laura J Kleeblad, Harshvardhan Chawla, Andrew D Pearle
BACKGROUND: Aseptic loosening is a common failure mode in cemented unicompartmental knee arthroplasty (UKA) and total knee arthroplasty (TKA). This led to the development of cementless designs but the historical outcomes were poor. Recent developments in cementless designs have improved outcomes, but the current status is unknown. Therefore, a systematic review was performed to assess recent outcomes of cementless knee arthroplasty. METHODS: A search was performed using PubMed, Embase and Cochrane systems and national registries for studies reporting outcomes since 2005...
December 3, 2016: Knee
https://www.readbyqxmd.com/read/27916580/annual-revision-rates-of-partial-versus-total-knee-arthroplasty-a-comparative-meta-analysis
#8
REVIEW
Harshvardhan Chawla, Jelle P van der List, Alexander B Christ, Maximiliano R Sobrero, Hendrik A Zuiderbaan, Andrew D Pearle
BACKGROUND: Utilization of unicompartmental knee arthroplasty (UKA) and patellofemoral arthroplasty (PFA) as alternatives to total knee arthroplasty (TKA) for unicompartmental knee osteoarthritis (OA) has increased. However, no single resource consolidates survivorship data between TKA and partial resurfacing options for each variant of unicompartmental OA. This meta-analysis compared survivorship between TKA and medial UKA (MUKA), lateral UKA (LUKA) and PFA using annual revision rate as a standardized metric...
December 1, 2016: Knee
https://www.readbyqxmd.com/read/27870817/clinical-pearls
#9
Andrew B Mick
No abstract text is available yet for this article.
December 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/27869622/acl-deficiency-increases-forces-on-the-medial-femoral-condyle-and-the-lateral-meniscus-with-applied-rotatory-loads
#10
Lucas S McDonald, James Boorman-Padgett, Robert Kent, Kyle Stone, Thomas L Wickiewicz, Andrew D Pearle, Carl W Imhauser
BACKGROUND: The articular surfaces and menisci act with the anterior cruciate ligament (ACL) to stabilize the knee joint. Their role in resisting applied rotatory loads characteristic of instability events is unclear despite commonly observed damage to these intra-articular structures in the acute and chronic ACL injury settings. METHODS: Ten fresh-frozen human cadaveric knees were mounted to a robotic manipulator. Combined valgus and internal rotation torques were applied in the presence and absence of a 300-N compressive load...
October 19, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27836938/statistics-for-sleep-and-biological-rhythms-research-from-distributions-and-displays-to-correlation-and-causation
#11
Matt T Bianchi, Andrew J K Phillips, Wei Wang, Elizabeth B Klerman
The Journal of Biological Rhythms will be publishing articles exploring analysis and statistical topics relevant to researchers in biological rhythms and sleep research. The goal is to provide an overview of the most common issues that arise in the analysis and interpretation of data in these fields. By using case examples and highlighting the pearls and pitfalls of statistical inference, the authors will identify and explain ways in which experimental scientists can avoid common analytical and statistical mistakes and use appropriate analytical and statistical methods in their research...
October 24, 2016: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/27833680/blog-and-podcast-watch-neurologic-emergencies
#12
Andrew Grock, Nikita Joshi, Anand Swaminathan, Salim Rezaie, Chris Gaafary, Michelle Lin
INTRODUCTION: The WestJEM Blog and Podcast Watch presents high quality open-access educational blogs and podcasts in emergency medicine (EM) based on the ongoing ALiEM Approved Instructional Resources (AIR) and AIR-Professional series. Both series critically appraise resources using an objective scoring rubric. This installment of the Blog and Podcast Watch highlights the topic of neurologic emergencies from the AIR series. METHODS: The AIR series is a continuously building curriculum that follows the Council of Emergency Medicine Residency Director's (CORD) annual testing schedule...
November 2016: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27810436/different-optimal-alignment-but-equivalent-functional-outcomes-in-medial-and-lateral-unicompartmental-knee-arthroplasty
#13
Jelle P van der List, Harshvardhan Chawla, Jordan C Villa, Andrew D Pearle
INTRODUCTION: Several differences in kinematics, functional outcomes and alignment exist between medial and lateral unicompartmental knee arthroplasty (UKA). Therefore, the purpose of this study was (1) to compare functional outcomes between both procedures with the hypothesis that both have equivalent outcomes and (2) to assess the role of preoperative and postoperative alignment on functional outcomes in both procedures. METHODS: Patients who underwent UKA were included when overall function - using Western Ontario and McMaster Universities Arthritis (WOMAC) score - and joint awareness - using Forgotten Joint Score (FJS) - were available preoperatively and at minimum two-year follow-up...
December 2016: Knee
https://www.readbyqxmd.com/read/27789095/deep-venous-thrombosis-prophylaxis-after-unicompartmental-knee-arthroplasty-a-prospective-study-on-the-safety-of-aspirin
#14
Tom Schmidt-Braekling, Andrew D Pearle, David J Mayman, Geoffrey H Westrich, Wenzel Waldstein, Friedrich Boettner
BACKGROUND: Although venous thromboembolism is one of the leading causes of morbidity after knee arthroplasty, little data exist on the risk of deep venous thrombosis (DVT) after unicompartmental knee arthroplasty (UKA). METHODS: We prospectively enrolled 112 patients undergoing UKA to determine the incidence of DVT utilizing aspirin 325 mg twice a day (BID) for 4 weeks postoperatively as DVT prophylaxis. The data were compared with a recent randomized controlled trial of patients undergoing total knee arthroplasty utilizing aspirin and Lovenox in conjunction with pneumatic compression devices...
September 28, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27782981/clinical-pearls
#15
Andrew B Mick
No abstract text is available yet for this article.
November 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/27737301/modern-indications-results-and-global-trends-in-the-use-of-unicompartmental-knee-arthroplasty-and-high-tibial-osteotomy-in-the-treatment-of-isolated-medial-compartment-osteoarthritis
#16
Hendrik A Zuiderbaan, Jelle P van der List, Laura J Kleeblad, Pauline Appelboom, Nanne P Kort, Andrew D Pearle, Maarten V Rademakers
In this review, we evaluate the modern indications, subjective outcome scores, and survivorship results of unicompartmental knee arthroplasty (UKA) and high tibial osteotomy (HTO) in the treatment of isolated medial compartment degeneration of the knee. In addition, in a thorough review of the literature, we evaluate global trends in the use of both methods. In our evaluation of articles, we note that inclusion criteria are relatively broader for UKA than for HTO, where age and body mass index should be considered before HTO surgery in order to optimize clinical outcome and survivorship results...
September 2016: American Journal of Orthopedics
https://www.readbyqxmd.com/read/27692825/establishing-age-specific-cost-effective-annual-revision-rates-for-unicompartmental-knee-arthroplasty-a-meta-analysis
#17
REVIEW
Harshvardhan Chawla, Hassan M Ghomrawi, Jelle P van der List, Ashley A Eggman, Hendrik A Zuiderbaan, Andrew D Pearle
BACKGROUND: Improved survivorship has contributed to the increased use of unicompartmental knee arthroplasty (UKA) as an alternative to total knee arthroplasty (TKA) for unicompartmental knee osteoarthritis. However, heterogeneity among cost-effectiveness analysis studies comparing UKA to TKA has prevented the derivation of discrete implant survivorship targets. The aim of this meta-analysis was to determine the age-stratified annual revision rate (ARR) threshold for UKA to become consistently cost-effective for unicompartmental knee osteoarthritis...
January 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27692783/the-role-of-patient-characteristics-on-the-choice-of-unicompartmental-versus-total-knee-arthroplasty-in-patients-with-medial-osteoarthritis
#18
Jelle P van der List, Harshvardhan Chawla, Jordan C Villa, Andrew D Pearle
BACKGROUND: Medial unicompartmental knee arthroplasty (UKA) and total knee arthroplasty (TKA) are both viable treatment options for medial osteoarthritis (OA). However, it remains unclear when to choose for which arthroplasty treatment. Goals of this study were therefore to (1) compare outcomes after both treatments and (2) assess which treatment has superior outcomes in different patient subgroups. METHODS: In this retrospective cohort study, 166 patients received the RESTORIS MCK Medial UKA and 63 patients the Vanguard TKA and were radiographically matched on isolated medial OA...
August 24, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27662361/clinical-pearls
#19
Andrew B Mick
No abstract text is available yet for this article.
October 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/27644010/impact-of-an-analgesia-based-sedation-protocol-on-mechanically-ventilated-patients-in-a-medical-intensive-care-unit
#20
Andrew C Faust, Pearl Rajan, Lyndsay A Sheperd, Carlos A Alvarez, Phyllis McCorstin, Rebecca L Doebele
BACKGROUND: Recent attention to adverse effects of intensive care unit (ICU) sedation has led to the use of strategies that target a "lighter" depth of sedation. Among these strategies are "analgosedation" protocols, which prioritize pain management and preferentially use IV opioids before administration of continuously infused sedatives such as propofol or midazolam. We hypothesized that using an analgosedation protocol would result in a shorter duration of mechanical ventilation than a protocol with greater emphasis on IV sedatives METHODS: : We conducted a retrospective study comparing the duration of mechanical ventilation before and after implementation of an analgosedation protocol in a 24-bed medical ICU...
October 2016: Anesthesia and Analgesia
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