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Andrew Pearle

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https://www.readbyqxmd.com/read/27923627/outcomes-of-cementless-unicompartmental-and-total-knee-arthroplasty-a-systematic-review
#1
REVIEW
Jelle P van der List, Dana L Sheng, Laura J Kleeblad, Harshvardhan Chawla, Andrew D Pearle
BACKGROUND: Aseptic loosening is a common failure mode in cemented unicompartmental knee arthroplasty (UKA) and total knee arthroplasty (TKA). This led to the development of cementless designs but the historical outcomes were poor. Recent developments in cementless designs have improved outcomes, but the current status is unknown. Therefore, a systematic review was performed to assess recent outcomes of cementless knee arthroplasty. METHODS: A search was performed using PubMed, Embase and Cochrane systems and national registries for studies reporting outcomes since 2005...
December 3, 2016: Knee
https://www.readbyqxmd.com/read/27916580/annual-revision-rates-of-partial-versus-total-knee-arthroplasty-a-comparative-meta-analysis
#2
REVIEW
Harshvardhan Chawla, Jelle P van der List, Alexander B Christ, Maximiliano R Sobrero, Hendrik A Zuiderbaan, Andrew D Pearle
BACKGROUND: Utilization of unicompartmental knee arthroplasty (UKA) and patellofemoral arthroplasty (PFA) as alternatives to total knee arthroplasty (TKA) for unicompartmental knee osteoarthritis (OA) has increased. However, no single resource consolidates survivorship data between TKA and partial resurfacing options for each variant of unicompartmental OA. This meta-analysis compared survivorship between TKA and medial UKA (MUKA), lateral UKA (LUKA) and PFA using annual revision rate as a standardized metric...
December 1, 2016: Knee
https://www.readbyqxmd.com/read/27870817/clinical-pearls
#3
Andrew B Mick
No abstract text is available yet for this article.
December 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/27869622/acl-deficiency-increases-forces-on-the-medial-femoral-condyle-and-the-lateral-meniscus-with-applied-rotatory-loads
#4
Lucas S McDonald, James Boorman-Padgett, Robert Kent, Kyle Stone, Thomas L Wickiewicz, Andrew D Pearle, Carl W Imhauser
BACKGROUND: The articular surfaces and menisci act with the anterior cruciate ligament (ACL) to stabilize the knee joint. Their role in resisting applied rotatory loads characteristic of instability events is unclear despite commonly observed damage to these intra-articular structures in the acute and chronic ACL injury settings. METHODS: Ten fresh-frozen human cadaveric knees were mounted to a robotic manipulator. Combined valgus and internal rotation torques were applied in the presence and absence of a 300-N compressive load...
October 19, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27836938/statistics-for-sleep-and-biological-rhythms-research-from-distributions-and-displays-to-correlation-and-causation
#5
Matt T Bianchi, Andrew J K Phillips, Wei Wang, Elizabeth B Klerman
The Journal of Biological Rhythms will be publishing articles exploring analysis and statistical topics relevant to researchers in biological rhythms and sleep research. The goal is to provide an overview of the most common issues that arise in the analysis and interpretation of data in these fields. By using case examples and highlighting the pearls and pitfalls of statistical inference, the authors will identify and explain ways in which experimental scientists can avoid common analytical and statistical mistakes and use appropriate analytical and statistical methods in their research...
October 24, 2016: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/27833680/blog-and-podcast-watch-neurologic-emergencies
#6
Andrew Grock, Nikita Joshi, Anand Swaminathan, Salim Rezaie, Chris Gaafary, Michelle Lin
INTRODUCTION: The WestJEM Blog and Podcast Watch presents high quality open-access educational blogs and podcasts in emergency medicine (EM) based on the ongoing ALiEM Approved Instructional Resources (AIR) and AIR-Professional series. Both series critically appraise resources using an objective scoring rubric. This installment of the Blog and Podcast Watch highlights the topic of neurologic emergencies from the AIR series. METHODS: The AIR series is a continuously building curriculum that follows the Council of Emergency Medicine Residency Director's (CORD) annual testing schedule...
November 2016: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27810436/different-optimal-alignment-but-equivalent-functional-outcomes-in-medial-and-lateral-unicompartmental-knee-arthroplasty
#7
Jelle P van der List, Harshvardhan Chawla, Jordan C Villa, Andrew D Pearle
INTRODUCTION: Several differences in kinematics, functional outcomes and alignment exist between medial and lateral unicompartmental knee arthroplasty (UKA). Therefore, the purpose of this study was (1) to compare functional outcomes between both procedures with the hypothesis that both have equivalent outcomes and (2) to assess the role of preoperative and postoperative alignment on functional outcomes in both procedures. METHODS: Patients who underwent UKA were included when overall function - using Western Ontario and McMaster Universities Arthritis (WOMAC) score - and joint awareness - using Forgotten Joint Score (FJS) - were available preoperatively and at minimum two-year follow-up...
December 2016: Knee
https://www.readbyqxmd.com/read/27789095/deep-venous-thrombosis-prophylaxis-after-unicompartmental-knee-arthroplasty-a-prospective-study-on-the-safety-of-aspirin
#8
Tom Schmidt-Braekling, Andrew D Pearle, David J Mayman, Geoffrey H Westrich, Wenzel Waldstein, Friedrich Boettner
BACKGROUND: Although venous thromboembolism is one of the leading causes of morbidity after knee arthroplasty, little data exist on the risk of deep venous thrombosis (DVT) after unicompartmental knee arthroplasty (UKA). METHODS: We prospectively enrolled 112 patients undergoing UKA to determine the incidence of DVT utilizing aspirin 325 mg twice a day (BID) for 4 weeks postoperatively as DVT prophylaxis. The data were compared with a recent randomized controlled trial of patients undergoing total knee arthroplasty utilizing aspirin and Lovenox in conjunction with pneumatic compression devices...
September 28, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27782981/clinical-pearls
#9
Andrew B Mick
No abstract text is available yet for this article.
November 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/27737301/modern-indications-results-and-global-trends-in-the-use-of-unicompartmental-knee-arthroplasty-and-high-tibial-osteotomy-in-the-treatment-of-isolated-medial-compartment-osteoarthritis
#10
Hendrik A Zuiderbaan, Jelle P van der List, Laura J Kleeblad, Pauline Appelboom, Nanne P Kort, Andrew D Pearle, Maarten V Rademakers
In this review, we evaluate the modern indications, subjective outcome scores, and survivorship results of unicompartmental knee arthroplasty (UKA) and high tibial osteotomy (HTO) in the treatment of isolated medial compartment degeneration of the knee. In addition, in a thorough review of the literature, we evaluate global trends in the use of both methods. In our evaluation of articles, we note that inclusion criteria are relatively broader for UKA than for HTO, where age and body mass index should be considered before HTO surgery in order to optimize clinical outcome and survivorship results...
September 2016: American Journal of Orthopedics
https://www.readbyqxmd.com/read/27692825/establishing-age-specific-cost-effective-annual-revision-rates-for-unicompartmental-knee-arthroplasty-a-meta-analysis
#11
Harshvardhan Chawla, Hassan M Ghomrawi, Jelle P van der List, Ashley A Eggman, Hendrik A Zuiderbaan, Andrew D Pearle
BACKGROUND: Improved survivorship has contributed to the increased use of unicompartmental knee arthroplasty (UKA) as an alternative to total knee arthroplasty (TKA) for unicompartmental knee osteoarthritis. However, heterogeneity among cost-effectiveness analysis studies comparing UKA to TKA has prevented the derivation of discrete implant survivorship targets. The aim of this meta-analysis was to determine the age-stratified annual revision rate (ARR) threshold for UKA to become consistently cost-effective for unicompartmental knee osteoarthritis...
August 28, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27692783/the-role-of-patient-characteristics-on-the-choice-of-unicompartmental-versus-total-knee-arthroplasty-in-patients-with-medial-osteoarthritis
#12
Jelle P van der List, Harshvardhan Chawla, Jordan C Villa, Andrew D Pearle
BACKGROUND: Medial unicompartmental knee arthroplasty (UKA) and total knee arthroplasty (TKA) are both viable treatment options for medial osteoarthritis (OA). However, it remains unclear when to choose for which arthroplasty treatment. Goals of this study were therefore to (1) compare outcomes after both treatments and (2) assess which treatment has superior outcomes in different patient subgroups. METHODS: In this retrospective cohort study, 166 patients received the RESTORIS MCK Medial UKA and 63 patients the Vanguard TKA and were radiographically matched on isolated medial OA...
August 24, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27662361/clinical-pearls
#13
Andrew B Mick
No abstract text is available yet for this article.
October 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/27644010/impact-of-an-analgesia-based-sedation-protocol-on-mechanically-ventilated-patients-in-a-medical-intensive-care-unit
#14
Andrew C Faust, Pearl Rajan, Lyndsay A Sheperd, Carlos A Alvarez, Phyllis McCorstin, Rebecca L Doebele
BACKGROUND: Recent attention to adverse effects of intensive care unit (ICU) sedation has led to the use of strategies that target a "lighter" depth of sedation. Among these strategies are "analgosedation" protocols, which prioritize pain management and preferentially use IV opioids before administration of continuously infused sedatives such as propofol or midazolam. We hypothesized that using an analgosedation protocol would result in a shorter duration of mechanical ventilation than a protocol with greater emphasis on IV sedatives METHODS: : We conducted a retrospective study comparing the duration of mechanical ventilation before and after implementation of an analgosedation protocol in a 24-bed medical ICU...
October 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27625713/blog-and-podcast-watch-pediatric-emergency-medicine
#15
Fareen Zaver, Michael Hansen, Evan Leibner, Andrew Little, Michelle Lin
INTRODUCTION: By critically appraising open access, educational blogs and podcasts in emergency medicine (EM) using an objective scoring instrument, this installment of the ALiEM (Academic Life in Emergency Medicine) Blog and Podcast Watch series curated and scored relevant posts in the specific areas of pediatric EM. METHODS: The Approved Instructional Resources - Professional (AIR-Pro) series is a continuously building curriculum covering a new subject area every two months...
September 2016: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27600634/current-state-of-computer-navigation-and-robotics-in-unicompartmental-and-total-knee-arthroplasty-a-systematic-review-with-meta-analysis
#16
Jelle P van der List, Harshvardhan Chawla, Leo Joskowicz, Andrew D Pearle
Recently, there is a growing interest in surgical variables that are intraoperatively controlled by orthopaedic surgeons, including lower leg alignment, component positioning and soft tissues balancing. Since more tight control over these factors is associated with improved outcomes of unicompartmental knee arthroplasty and total knee arthroplasty (TKA), several computer navigation and robotic-assisted systems have been developed. Although mechanical axis accuracy and component positioning have been shown to improve with computer navigation, no superiority in functional outcomes has yet been shown...
September 6, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/27576611/antiangiogenic-antibody-improves-melanoma-detection-by-fluorescently-labeled-therapeutic-antibodies
#17
Larissa Sweeny, Andrew Prince, Neel Patel, Lindsay S Moore, Eben L Rosenthal, Brian B Hughley, Jason M Warram
OBJECTIVE: Evaluate if vascular normalization with an antiangiogenic monoclonal antibody improves detection of melanoma using fluorescently labeled antibody-based imaging. STUDY DESIGN: Preclinical. METHODS: Panitumumab and control IgG were covalently linked to a near-infrared fluorescent probe (IRDye800CW). Immunodeficient mice with ear xenografts of melanoma cell lines (A375 and SKMEL5) were systemically injected (200 μg, tail vein) with either IgG-IRDye800CW, panitumumab-IRDye800CW, or a combination (bevacizumab [5mg/kg], administered 72 hours prepanitumumab-IRDye800CW) (n = 5)...
December 2016: Laryngoscope
https://www.readbyqxmd.com/read/27560693/clinical-pearls
#18
Andrew B Mick
No abstract text is available yet for this article.
September 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/27496910/comparison-of-lateral-closing-wedge-versus-medial-opening-wedge-high-tibial-osteotomy-on-knee-joint-alignment-and-kinematics-in-the-acl-deficient-knee
#19
Anil S Ranawat, Benedict U Nwachukwu, Andrew D Pearle, Hendrik A Zuiderbaan, Kenneth D Weeks, Saker Khamaisy
BACKGROUND: Lateral closing-wedge (LCW) and medial opening-wedge (MOW) high tibial osteotomies (HTOs) correct varus knee alignment and stabilize the anterior cruciate ligament (ACL)-deficient knee. Tibiofemoral and patellofemoral alignment and kinematics after HTO are not well quantified. PURPOSE: To compare the effect of LCW and MOW HTO on tibiofemoral and patellofemoral alignment in the ACL-deficient knee. STUDY DESIGN: Controlled laboratory study...
December 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27440804/acl-fibers-near-the-lateral-intercondylar-ridge-are-the-most-load-bearing-during-stability-examinations-and-isometric-through-passive-flexion
#20
Danyal H Nawabi, Scott Tucker, Kevin A Schafer, Hendrik Aernout Zuiderbaan, Joseph T Nguyen, Thomas L Wickiewicz, Carl W Imhauser, Andrew D Pearle
BACKGROUND: The femoral insertion of the anterior cruciate ligament (ACL) has direct and indirect fiber types located within the respective high (anterior) and low (posterior) regions of the femoral footprint. HYPOTHESIS: The fibers in the high region of the ACL footprint carry more force and are more isometric than the fibers in the low region of the ACL footprint. STUDY DESIGN: Controlled laboratory study. METHODS: Ten fresh-frozen cadaveric knees were mounted to a robotic manipulator...
October 2016: American Journal of Sports Medicine
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