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Andrew Pearle

Hendrik A Zuiderbaan, Jelle P van der List, Pauline Appelboom, Nanne P Kort, Andrew D Pearle, Maarten V Rademakers
In this review, we evaluate the modern indications, subjective outcome scores, and survivorship results of unicompartmental knee arthroplasty (UKA) and high tibial osteotomy (HTO) in the treatment of isolated medial compartment degeneration of the knee. In addition, in a thorough review of the literature, we evaluate global trends in the use of both methods. In our evaluation of articles, we note that inclusion criteria are relatively broader for UKA than for HTO, where age and body mass index should be considered before HTO surgery in order to optimize clinical outcome and survivorship results...
September 2016: American Journal of Orthopedics
Harshvardhan Chawla, Hassan M Ghomrawi, Jelle P van der List, Ashley A Eggman, Hendrik A Zuiderbaan, Andrew D Pearle
BACKGROUND: Improved survivorship has contributed to the increased use of unicompartmental knee arthroplasty (UKA) as an alternative to total knee arthroplasty (TKA) for unicompartmental knee osteoarthritis. However, heterogeneity among cost-effectiveness analysis studies comparing UKA to TKA has prevented the derivation of discrete implant survivorship targets. The aim of this meta-analysis was to determine the age-stratified annual revision rate (ARR) threshold for UKA to become consistently cost-effective for unicompartmental knee osteoarthritis...
August 28, 2016: Journal of Arthroplasty
Jelle P van der List, Harshvardhan Chawla, Jordan C Villa, Andrew D Pearle
BACKGROUND: Medial unicompartmental knee arthroplasty (UKA) and total knee arthroplasty (TKA) are both viable treatment options for medial osteoarthritis (OA). However, it remains unclear when to choose for which arthroplasty treatment. Goals of this study were therefore to (1) compare outcomes after both treatments and (2) assess which treatment has superior outcomes in different patient subgroups. METHODS: In this retrospective cohort study, 166 patients received the RESTORIS MCK Medial UKA and 63 patients the Vanguard TKA and were radiographically matched on isolated medial OA...
August 24, 2016: Journal of Arthroplasty
Andrew B Mick
No abstract text is available yet for this article.
October 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
Andrew C Faust, Pearl Rajan, Lyndsay A Sheperd, Carlos A Alvarez, Phyllis McCorstin, Rebecca L Doebele
BACKGROUND: Recent attention to adverse effects of intensive care unit (ICU) sedation has led to the use of strategies that target a "lighter" depth of sedation. Among these strategies are "analgosedation" protocols, which prioritize pain management and preferentially use IV opioids before administration of continuously infused sedatives such as propofol or midazolam. We hypothesized that using an analgosedation protocol would result in a shorter duration of mechanical ventilation than a protocol with greater emphasis on IV sedatives METHODS: : We conducted a retrospective study comparing the duration of mechanical ventilation before and after implementation of an analgosedation protocol in a 24-bed medical ICU...
October 2016: Anesthesia and Analgesia
Fareen Zaver, Michael Hansen, Evan Leibner, Andrew Little, Michelle Lin
INTRODUCTION: By critically appraising open access, educational blogs and podcasts in emergency medicine (EM) using an objective scoring instrument, this installment of the ALiEM (Academic Life in Emergency Medicine) Blog and Podcast Watch series curated and scored relevant posts in the specific areas of pediatric EM. METHODS: The Approved Instructional Resources - Professional (AIR-Pro) series is a continuously building curriculum covering a new subject area every two months...
September 2016: Western Journal of Emergency Medicine
Jelle P van der List, Harshvardhan Chawla, Leo Joskowicz, Andrew D Pearle
Recently, there is a growing interest in surgical variables that are intraoperatively controlled by orthopaedic surgeons, including lower leg alignment, component positioning and soft tissues balancing. Since more tight control over these factors is associated with improved outcomes of unicompartmental knee arthroplasty and total knee arthroplasty (TKA), several computer navigation and robotic-assisted systems have been developed. Although mechanical axis accuracy and component positioning have been shown to improve with computer navigation, no superiority in functional outcomes has yet been shown...
September 6, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Larissa Sweeny, Andrew Prince, Neel Patel, Lindsay S Moore, Eben L Rosenthal, Brian B Hughley, Jason M Warram
OBJECTIVE: Evaluate if vascular normalization with an antiangiogenic monoclonal antibody improves detection of melanoma using fluorescently labeled antibody-based imaging. STUDY DESIGN: Preclinical. METHODS: Panitumumab and control IgG were covalently linked to a near-infrared fluorescent probe (IRDye800CW). Immunodeficient mice with ear xenografts of melanoma cell lines (A375 and SKMEL5) were systemically injected (200 μg, tail vein) with either IgG-IRDye800CW, panitumumab-IRDye800CW, or a combination (bevacizumab [5mg/kg], administered 72 hours prepanitumumab-IRDye800CW) (n = 5)...
August 31, 2016: Laryngoscope
Andrew B Mick
No abstract text is available yet for this article.
September 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
Anil S Ranawat, Benedict U Nwachukwu, Andrew D Pearle, Hendrik A Zuiderbaan, Kenneth D Weeks, Saker Khamaisy
BACKGROUND: Lateral closing-wedge (LCW) and medial opening-wedge (MOW) high tibial osteotomies (HTOs) correct varus knee alignment and stabilize the anterior cruciate ligament (ACL)-deficient knee. Tibiofemoral and patellofemoral alignment and kinematics after HTO are not well quantified. PURPOSE: To compare the effect of LCW and MOW HTO on tibiofemoral and patellofemoral alignment in the ACL-deficient knee. STUDY DESIGN: Controlled laboratory study...
August 5, 2016: American Journal of Sports Medicine
Danyal H Nawabi, Scott Tucker, Kevin A Schafer, Hendrik Aernout Zuiderbaan, Joseph T Nguyen, Thomas L Wickiewicz, Carl W Imhauser, Andrew D Pearle
BACKGROUND: The femoral insertion of the anterior cruciate ligament (ACL) has direct and indirect fiber types located within the respective high (anterior) and low (posterior) regions of the femoral footprint. HYPOTHESIS: The fibers in the high region of the ACL footprint carry more force and are more isometric than the fibers in the low region of the ACL footprint. STUDY DESIGN: Controlled laboratory study. METHODS: Ten fresh-frozen cadaveric knees were mounted to a robotic manipulator...
October 2016: American Journal of Sports Medicine
Charlotte M Beddoes, Johanna Berge, Julia E Bartenstein, Kathrin Lange, Andrew J Smith, Richard K Heenan, Wuge H Briscoe
Using high pressure small angle X-ray scattering (HP-SAXS), we have studied monoolein (MO) mesophases at 18 wt% hydration in the presence of 10 nm silica nanoparticles (NPs) at NP-lipid number ratios (ν) of 1 × 10(-6), 1 × 10(-5) and 1 × 10(-4) over the pressure range 1-2700 bar and temperature range 20-60 °C. In the absence of the silica NPs, the pressure-temperature (p-T) phase diagram of monoolein exhibited inverse bicontinuous cubic gyroid (Q), lamellar alpha (Lα), and lamellar crystalline (Lc) phases...
July 13, 2016: Soft Matter
Jelle P van der List, Harshvardhan Chawla, Andrew D Pearle
Unicompartmental knee arthroplasty and total knee arthroplasty are reliable treatment options for osteoarthritis. In order to improve survivorship rates, variables that are intraoperatively controlled by the orthopedic surgeon are being evaluated. These variables include lower leg alignment, soft tissue balance, joint line maintenance, and tibial and femoral component alignment, size, and fixation methods. Since tighter control of these factors is associated with improved outcomes of knee arthroplasty, several computer-assisted surgery systems have been developed...
May 2016: American Journal of Orthopedics
Ran Thein, James Boorman-Padgett, Kyle Stone, Thomas L Wickiewicz, Carl W Imhauser, Andrew D Pearle
BACKGROUND: Injury to the lateral capsular tissues of the knee may accompany rupture of the anterior cruciate ligament (ACL). A distinct lateral structure, the anterolateral ligament, has been identified, and reconstruction strategies for this tissue in combination with ACL reconstruction have been proposed. However, the biomechanical function of the anterolateral ligament is not well understood. Thus, this study had two research questions: (1) What is the contribution of the anterolateral ligament to knee stability in the ACL-sectioned knee? (2) Does the anterolateral ligament bear increased load in the absence of the ACL? METHODS: Twelve cadaveric knees from donors who were a mean (and standard deviation) of 43 ± 15 years old at the time of death were loaded using a robotic manipulator to simulate clinical tests of the pivot shift and anterior stability...
June 1, 2016: Journal of Bone and Joint Surgery. American Volume
Ran Thein, Elad Spitzer, John Doyle, Saker Khamaisy, Danyal H Nawabi, Harshvardhan Chawla, Joseph D Lipman, Andrew D Pearle
BACKGROUND: Impingement of anterior cruciate ligament (ACL) grafts against the femoral notch and the posterior cruciate ligament (PCL) is thought to be influenced primarily by tunnel position and graft orientation. Recent data have implied that the native ACL is ribbon-shaped. PURPOSE: To evaluate the 3-dimensional shape and cross-sectional area of the native ACL versus the ACL graft and to compare the degree of impingement against the femoral notch and PCL. STUDY DESIGN: Cross-sectional study; Level of evidence, 3...
August 2016: American Journal of Sports Medicine
Jelle P van der List, Harshvardhan Chawla, Hendrik A Zuiderbaan, Andrew D Pearle
BACKGROUND: In 1989, Kozinn and Scott introduced strict exclusion criteria for unicompartmental knee arthroplasty (UKA). Because outcomes have improved with modern techniques and implants, these criteria have now been challenged. Therefore, the goal was to assess the role of these criteria on (1) functional outcomes and (2) revision rates of medial UKA. The hypothesis was that, with modern surgical techniques and implants, these traditional exclusion criteria are no longer strict contraindications for UKA...
May 9, 2016: Journal of Arthroplasty
Van P Thompson, Andrew B Schenkel, Bapanaiah Penugonda, Mark S Wolff, Gregory G Zeller, Hongyu Wu, Don Vena, Ashley C Grill, Frederick A Curro
The International Caries Detection and Assessment System (ICDAS II) and the Caries Classification System (CCS) are caries stage description systems proposed for adoption into clinical practice. This pilot study investigated clinicians' training in and use of these systems for detection of early caries and recommendations for individual tooth treatment. Patient participants (N = 8) with a range of noncavitated lesions (CCS ranks 2 and 4 and ICDAS II ranks 2-4) identified by a team of calibrated examiners were recruited from the New York University College of Dentistry clinic...
May 2016: General Dentistry
Lidia Maroñas-Jiménez, Andrew C Krakowski
Acne vulgaris presenting from birth to preadolescence can be confusing to diagnose and even more challenging to evaluate and manage. The differential diagnosis of acne varies by age and, in some cases (especially when it presents in midchildhood), deserves a thorough evaluation to rule out underlying systemic abnormalities. Acne management strategies, including factors affecting adherence to the treatment regimen, may be influenced by the patient's age. This article presents an overview of the clinical presentations of acne by age and our approach to evaluation and management of this common condition...
April 2016: Dermatologic Clinics
Gokce Yildirim, Ananthkrishnan Gopalakrishnan, Robert A Davignon, John W Parker, Harshvardhan Chawla, Andrew D Pearle
BACKGROUND: Aseptic loosening is the primary cause of failure for both cemented and cementless unicondylar knee replacements (UKRs). Micromotion and subsidence of tibial baseplate are two causes of failure, due to poor fixation and misalignment, respectively. METHODS: Stair ascent activity profiles from Bergmann et al and Li et al were used. Biphasic Sawbones models were prepared according to the surgical techniques of traditional and novel cementless UKRs. Implants were tested for 10,000 cycles representing post-operative bone interdigitation period, and micromotion was observed using speckle pattern measurements, which demonstrated sufficient resolution...
September 2016: Journal of Arthroplasty
Saker Khamaisy, Hendrik A Zuiderbaan, Jelle P van der List, Denis Nam, Andrew D Pearle
BACKGROUND: Osteoarthritic progression of the lateral compartment remains a leading indication for medial unicompartmental knee arthroplasty (UKA) revision. Therefore, the purpose of this study was to evaluate the alterations of the lateral compartment congruence and joint space width (JSW) following medial UKA. METHODS: Retrospectively, lateral compartment congruence and JSW were evaluated in 174 knees (74 females, 85 males, mean age 65.5years; SD±10.1) preoperatively and six weeks postoperatively, and compared to 41 healthy knees (26 men, 15 women, mean age 33...
June 2016: Knee
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