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https://www.readbyqxmd.com/read/29333023/nivolumab-pearls-of-evidence
#1
REVIEW
Pratishtha B Chaudhari
Purpose: Nivolumab is one of the most extensively studied immune checkpoint inhibitors across various tumor types. In this narrative review, the current clinical efficacy and safety data of anti-programmed death-1 (PD-1) nivolumab for nonsmall cell lung cancer (NSCLC) and renal cell cancer (RCC) are elucidated. Methods: Systematic search was done on Pubmed, Medline, Embase, Web of Knowledge, and Cochrane Central through September 2016 for controlled prospective interventional studies of nivolumab across two indications - NSCLC and RCC...
October 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29332368/-pearl-oyster-a-new-ultrasonographic-sign-of-the-regressed-testicular-tumor
#2
Lucio Dell'Atti, Andrea Benedetto Galosi
No abstract text is available yet for this article.
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29329533/nutritional-status-of-in-school-children-and-its-associated-factors-in-denkyembour-district-eastern-region-ghana-comparing-schools-with-feeding-and-non-school-feeding-policies
#3
Mavis Pearl Kwabla, Charlotte Gyan, Francis Zotor
BACKGROUND: Childhood malnutrition still remains a major public health problem impacting negatively on the academic aptitude of school-aged children (SAC) particularly in limited resource countries. The Government of Ghana in collaboration with the Dutch Government introduced the school feeding programme (SFP) to boost the nutritional status of SAC in the country. This study sought to compare the nutritional status of SAC enrolled in schools with the SFP and SAC enrolled in schools without the SFP in place for the purpose of identifying which group has the higher rate of malnutrition...
January 12, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/29326194/association-of-erythrocyte-parameters-with-metabolic-syndrome-in-the-pearl-river-delta-region-of-china-a-cross-sectional-study
#4
Ling Ling Huang, Dong-Mei Dou, Nan Liu, Xiao Xiao Wang, Li-Ying Fu, Xiao Wu, Peixi Wang
OBJECTIVE: Increasing studies have reported that erythrocyte parameters, including red blood cells (RBCs), haematocrit (HCT), haemoglobin (Hb) and red blood cell distribution width (RDW), are associated with metabolic syndrome (MetS) in adults worldwide. However, the association, stratified by sex, remains to be elucidated, particularly in the Pearl River Delta region of China. Therefore, our aim was to explore the association of erythrocyte parameters with MetS, stratified by sex, in the Pearl River Delta region of China...
January 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29323067/modified-cajal-s-trichrome-stain-as-a-diagnostic-aid-in-the-study-of-epithelial-pathology
#5
Karpagaselvi Sanjai, Anjum Baker, Lokesh Papiah Reddy, Bhavna Pandey
BACKGROUND: Diagnosis of initial epithelial pathology maybe difficult in Squamous Cell Carcinoma (SCC), Carcinoma In Situ and other atypical epithelial malignancies, under routine Haematoxylin and Eosin (H and E) stain. The detection of minor basement membrane alterations in doubtful cases is both time consuming and confusing. AIMS: To evaluate efficacy of Modified Cajal's Trichrome Stain (CTS) in relation to Haematoxylin and Eosin for study of epithelial dysplasia, carcinoma in situ, micro invasive SCC, frank SCC, and SCC in lymph nodes...
October 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29320333/prostate-specific-membrane-antigen-pet-clinical-utility-in-prostate-cancer-normal-patterns-pearls-and-pitfalls
#6
Michael S Hofman, Rodney J Hicks, Tobias Maurer, Matthias Eiber
Prostate-specific membrane antigen (PSMA) is a transmembrane glycoprotein that is overexpressed in prostate cancer. Radiolabeled small molecules that bind with high affinity to its active extracellular center have emerged as a potential new diagnostic standard of reference for prostate cancer, resulting in images with extraordinary tumor-to-background contrast. Currently, gallium 68 (68Ga)-PSMA-11 (or HBED-PSMA) is the most widely used radiotracer for PSMA positron emission tomography (PET)/computed tomography (CT) or PSMA PET/magnetic resonance (MR) imaging...
January 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29319389/top-10-tips-palliative-care-clinicians-should-know-when-caring-for-patients-with-ovarian-cancer
#7
Brittany A Davidson, Haley A Moss, Arif H Kamal
The vast majority of women diagnosed with ovarian cancer present with advanced-stage disease with a five-year survival rate less than 50%. Studies have shown that in the past, gynecologic oncologists were not routinely collaborating with palliative care physicians resulting in goals of care planning often not occurring until the last 30 days before death. In recent years, professional societies have been increasingly more vocal about the importance of incorporating palliative care early in a patient's disease course...
January 10, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29317743/genome-wide-comparisons-reveal-evidence-for-a-species-complex-in-the-black-lip-pearl-oyster-pinctada-margaritifera-bivalvia-pteriidae
#8
Monal M Lal, Paul C Southgate, Dean R Jerry, Kyall R Zenger
Evolutionary relationships in the black-lip pearl oyster Pinctada margaritifera which is highly valued for pearl production remain poorly understood. This species possesses an 18,000 km Indo-Pacific natural distribution, and its current description includes six subspecies defined exclusively on morphological characters. To evaluate its taxonomic identity using molecular data, 14 populations in both the Indian and Pacific Oceans (n = 69), and the congeneric taxa P. maxima and P. mazatlanica (n = 29 and n = 10, respectively) were sampled...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29317424/correction-effect-of-iron-and-zinc-biofortified-pearl-millet-consumption-on-growth-and-immune-competence-in-children-aged-12-18-months-in-india-study-protocol-for-a-randomised-controlled-trial
#9
https://www.readbyqxmd.com/read/29314260/approach-to-the-jewelry-aficionado
#10
Lauren A Ivey, Brittanya A Limone, Sharon E Jacob
Children's and teens' frequent use of inexpensive "costume" jewelry exposes them to a variety of contact allergens. Greater use heightens the risk of developing allergic contact dermatitis, especially in the setting of body piercings. Several clinical pearls, prevention strategies, and avoidance alternatives are provided in this article to guide clinicians and patients in the management of jewelry-related allergic contact dermatitis.
January 4, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29313489/associability-modulated-loss-learning-is-increased-in-posttraumatic-stress-disorder
#11
Vanessa M Brown, Lusha Zhu, John M Wang, B Christopher Frueh, Brooks King-Casas, Pearl H Chiu
Disproportionate reactions to unexpected stimuli in the environment are a cardinal symptom of posttraumatic stress disorder (PTSD). Here, we test whether these heightened responses are associated with disruptions in distinct components of reinforcement learning. Specifically, using functional neuroimaging, a loss-learning task, and a computational model-based approach, we assessed the mechanistic hypothesis that overreactions to stimuli in PTSD arise from anomalous gating of attention during learning (i.e., associability)...
January 9, 2018: ELife
https://www.readbyqxmd.com/read/29311629/climate-warming-as-a-possible-trigger-of-keystone-mussel-population-decline-in-oligotrophic-rivers-at-the-continental-scale
#12
Ivan N Bolotov, Alexander A Makhrov, Mikhail Yu Gofarov, Olga V Aksenova, Paul E Aspholm, Yulia V Bespalaya, Mikhail B Kabakov, Yulia S Kolosova, Alexander V Kondakov, Thomas Ofenböck, Andrew N Ostrovsky, Igor Yu Popov, Ted von Proschwitz, Mudīte Rudzīte, Māris Rudzītis, Svetlana E Sokolova, Ilmari Valovirta, Ilya V Vikhrev, Maxim V Vinarski, Alexey A Zotin
The effects of climate change on oligotrophic rivers and their communities are almost unknown, albeit these ecosystems are the primary habitat of the critically endangered freshwater pearl mussel and its host fishes, salmonids. The distribution and abundance of pearl mussels have drastically decreased throughout Europe over the last century, particularly within the southern part of the range, but causes of this wide-scale extinction process are unclear. Here we estimate the effects of climate change on pearl mussels based on historical and recent samples from 50 rivers and 6 countries across Europe...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29299722/successful-recovery-from-misdirection-syndrome-in-nanophthalmic-eyes-by-performing-an-anterior-vitrectomy-through-the-anterior-chamber
#13
Andi Akhmad Faisal, Muhammad Irfan Kamaruddin, Ryotaro Toda, Yoshiaki Kiuchi
PURPOSE: To determine the effectiveness of iridectomy, capsulotomy and anterior vitrectomy through the anterior chamber to treat misdirection syndrome in pseudophakic nanophthalmic eyes. METHODS: This was a non-comparative study of seven nanophthalmic eyes from four consecutive patients. All eyes developed misdirection syndrome after successful cataract surgery. Treatment for misdirection syndrome involved capsulotomy and anterior vitrectomy through a peripheral iridectomy from the anterior chamber using a 25-gauge vitreous cutter...
January 3, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29291565/a-regional-scale-investigation-on-factors-controlling-the-groundwater-chemistry-of-various-aquifers-in-a-rapidly-urbanized-area-a-case-study-of-the-pearl-river-delta
#14
Guanxing Huang, Chunyan Liu, Jichao Sun, Ming Zhang, Jihong Jing, Liangping Li
A growing population accompanied by urbanization has increased groundwater resource demands in the Pearl River Delta (PRD) area, southern China, and a comprehensive understanding of the groundwater chemistry in the PRD is necessary. The aims of this study were to investigate the groundwater chemistry in various aquifers in the PRD on a regional scale and to discuss the factors that control the groundwater chemistries of different types of aquifers. In addition, the effect of the expansion of construction land on the groundwater chemistry was also taken into consideration in this study...
December 29, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29288545/a-randomized-trial-of-lorcaserin-and-lifestyle-counseling-for-maintaining-weight-loss-achieved-with-a-low-calorie-diet
#15
Jena Shaw Tronieri, Thomas A Wadden, Robert I Berkowitz, Ariana M Chao, Rebecca L Pearl, Naji Alamuddin, Sharon M Leonard, Ray Carvajal, Zayna M Bakizada, Emilie Pinkasavage, Kathryn A Gruber, Olivia A Walsh, Nasreen Alfaris
OBJECTIVE: Improving the maintenance of lost weight remains a critical challenge, which can be addressed by long-term behavioral and/or pharmacological interventions. METHODS: This study investigated the efficacy of combined behavioral and pharmacological treatment in facilitating weight loss maintenance (WLM) in 137 adults (86.1% female; 68.6% black; BMI = 37.0 ± 5.6 kg/m2 ) who had lost ≥ 5% of initial weight during a 14-week low-calorie diet (LCD) program (mean = 9...
December 29, 2017: Obesity
https://www.readbyqxmd.com/read/29282873/reconsidering-the-psychosocial-behavioral-evaluation-required-prior-to-bariatric-surgery
#16
EDITORIAL
Rebecca L Pearl, Kelly C Allison, Jena Shaw Tronieri, Thomas A Wadden
No abstract text is available yet for this article.
December 27, 2017: Obesity
https://www.readbyqxmd.com/read/29281675/northward-range-expansion-of-ixodes-scapularis-evident-over-a-short-timescale-in-ontario-canada
#17
Katie M Clow, Patrick A Leighton, Nicholas H Ogden, L Robbin Lindsay, Pascal Michel, David L Pearl, Claire M Jardine
The invasion of the blacklegged tick, Ixodes scapularis into Ontario, Canada poses a significant risk to public health because it is a vector for numerous pathogens, including Borrelia burgdorferi sensu stricto, the causative agent of Lyme disease. Baseline field sampling in 2014 and 2015 detected I. scapularis and B. burgdorferi at sites across southern, eastern and central Ontario, including a hot spot in eastern Ontario. A "speed of spread" model for I. scapularis developed by Leighton and colleagues (2012) estimated that the tick's range was expanding northward at 46 km/year...
2017: PloS One
https://www.readbyqxmd.com/read/29281127/bone-tissue-collagen-maturity-and-mineral-content-increase-with-sustained-hyperglycemia-in-the-kk-ay-murine-model-of-type-2-diabetes
#18
Heather B Hunt, Jared C Pearl, David R Diaz, Karen B King, Eve Donnelly
Type 2 diabetes mellitus (T2DM) increases fracture risk for a given bone mineral density, which suggests that T2DM changes bone tissue properties independently of bone mass. In this study, we assessed the effects of hyperglycemia on bone tissue compositional properties, enzymatic collagen crosslinks, and advanced glycation endproducts (AGEs) in the KK-Ay murine model of T2DM using Fourier transform infrared imaging and high-performance liquid chromatography. Compared to KK-aa littermate controls (n = 8), proximal femoral bone tissue of KK-Ay mice (n = 14) exhibited increased collagen maturity, increased mineral content, and less heterogeneous mineral properties...
December 27, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29276521/simulated-optimum-sowing-date-for-forage-pearl-millet-cultivars-in-multilocation-trials-in-brazilian-semi-arid-region
#19
Rafael D Santos, Kenneth J Boote, Lynn E Sollenberger, Andre L A Neves, Luiz G R Pereira, Carolina B Scherer, Lucio C Gonçalves
Forage production is primarily limited by weather conditions under dryland production systems in Brazilian semi-arid regions, therefore sowing at the appropriate time is critical. The objectives of this study were to evaluate the CSM-CERES-Pearl Millet model from the DSSAT software suite for its ability to simulate growth, development, and forage accumulation of pearl millet [Pennisetum glaucum (L.) R.] at three Brazilian semi-arid locations, and to use the model to study the impact of different sowing dates on pearl millet performance for forage...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29275270/distribution-and-partitioning-of-polybrominated-diphenyl-ethers-in-sediments-from-the-pearl-river-delta-and-guiyu-south-china
#20
Youda Huang, Dainan Zhang, Yu Yang, Xiangying Zeng, Yong Ran
Polybrominated diphenyl ethers (PBDEs) were investigated by GC-NCI-MS in sediments collected from the Pearl River Delta (PRD) and Guiyu town, South China. The concentrations of ∑39PBDEs and BDE 209 were in the ranges of 0.31-38.9 ng g-1 and 12.2-488 ng g-1 in the PRD, and 2.57-21,207 ng g-1 and 7.02-66,573 ng g-1 in Guiyu, respectively. The levels of PBDEs in Dongjiang River (DJ), Zhujiang River (ZJ), and Beijiang River (BJ), and Guiyu (GY) followed the order: GY > DJ > ZJ > BJ...
December 21, 2017: Environmental Pollution
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