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https://www.readbyqxmd.com/read/28432909/source-receptor-relationships-for-pm2-5-during-typical-pollution-episodes-in-the-pearl-river-delta-city-cluster-china
#1
Yiming Liu, Yingying Hong, Qi Fan, Xuemei Wang, Pakwai Chan, Xiaoyang Chen, Anqi Lai, Mingjie Wang, Xunlai Chen
Located in the Southern China monsoon region, pollution days in Pearl River Delta (PRD) were classified into "Western type", "Central type" or "Eastern type", with a relative percentage of 67%, 24% and 9%, respectively. Using this classification system, three typical pollution events were selected for numerical simulations using the WRF-Chem model. The source sensitivity method for anthropogenic emissions of PM2.5 and its precursors was applied to identify the source-receptor relationships for PM2.5 among 9 cities in PRD...
April 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28430674/continuous-eeg-in-pediatric-critical-care-yield-and-efficiency-of-seizure-detection
#2
Arnold J Sansevere, Elizabeth D Duncan, Mark H Libenson, Tobias Loddenkemper, Phillip L Pearl, Robert C Tasker
PURPOSE: Our goal was to define the duration of continuous EEG (cEEG) monitoring needed to adequately capture electrographic seizures and EEG status epilepticus in the pediatric intensive care unit using clinical and background EEG features. METHODS: Retrospective study of patients aged 1 month to 21 years admitted to a tertiary pediatric intensive care unit and undergoing cEEG (>3 hours). Clinical data collected included admission diagnosis, EEG background features, and time variables including time to first seizure after initiation of cEEG...
April 20, 2017: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/28425994/modulating-the-therapeutic-response-of-tumours-to-dietary-serine-and-glycine-starvation
#3
Oliver D K Maddocks, Dimitris Athineos, Eric C Cheung, Pearl Lee, Tong Zhang, Niels J F van den Broek, Gillian M Mackay, Christiaan F Labuschagne, David Gay, Flore Kruiswijk, Julianna Blagih, David F Vincent, Kirsteen J Campbell, Fatih Ceteci, Owen J Sansom, Karen Blyth, Karen H Vousden
The non-essential amino acids serine and glycine are used in multiple anabolic processes that support cancer cell growth and proliferation (reviewed in ref. 1). While some cancer cells upregulate de novo serine synthesis, many others rely on exogenous serine for optimal growth. Restriction of dietary serine and glycine can reduce tumour growth in xenograft and allograft models. Here we show that this observation translates into more clinically relevant autochthonous tumours in genetically engineered mouse models of intestinal cancer (driven by Apc inactivation) or lymphoma (driven by Myc activation)...
April 19, 2017: Nature
https://www.readbyqxmd.com/read/28423774/the-pearl-data-warehouse-initial-challenges-faced-with-semantic-and-syntactic-interoperability
#4
Samhar Mahmoud, Andy Boyd, Vasa Curcin, Richard Bache, Asad Ali, Simon Miles, Adel Taweel, Brendan Delaney, John Macleod
Data about patients are available from diverse sources, including those routinely collected as individuals interact with service providers, and those provided directly by individuals through surveys. Linking these data can lead to a more complete picture about the individual, to inform either care decision making or research investigations. However, post-linkage, differences in data recording systems and formats present barriers to achieving these aims. This paper describes an approach to combine linked GP records with study observations, and reports initial challenges related to semantic and syntactic interoperability issues...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28423505/identification-and-analysis-of-mutational-hotspots-in-oncogenes-and-tumour-suppressors
#5
Hanadi Baeissa, Graeme Benstead-Hume, Christopher J Richardson, Frances M G Pearl
BACKGROUND: The key to interpreting the contribution of a disease-associated mutation in the development and progression of cancer is an understanding of the consequences of that mutation both on the function of the affected protein and on the pathways in which that protein is involved. Protein domains encapsulate function and position-specific domain based analysis of mutations have been shown to help elucidate their phenotypes. RESULTS: In this paper we examine the domain biases in oncogenes and tumour suppressors, and find that their domain compositions substantially differ...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28420231/biological-control-of-aflatoxin-contamination-in-us-crops-and-the-use-of-bioplastic-formulations-of-aspergillus-flavus-biocontrol-strains-to-optimize-application-strategies
#6
Hamed K Abbas, Cesare Accinelli, W Thomas Shier
Aflatoxin contamination has a major economic impact on crop production in southern USA. Reduction of aflatoxin contamination in harvested crops has been achieved by applying non-aflatoxigenic biocontrol Aspergillus flavus strains that can out-compete wild aflatoxigenic A. flavus, reducing their numbers at the site of application. Currently, the standard method for applying biocontrol A. flavus strains to soil is using a nutrient-supplying carrier (e.g., pearled barley for Afla-Guard®). Granules of bioplastic (partially acetylated corn starch) have been investigated as an alternative nutritive carrier for biocontrol agents...
April 19, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28419921/development-of-pm2-5-and-no2-models-in-a-lur-framework-incorporating-satellite-remote-sensing-and-air-quality-model-data-in-pearl-river-delta-region-china
#7
Xiaofan Yang, Yixuan Zheng, Guannan Geng, Huan Liu, Hanyang Man, Zhaofeng Lv, Kebin He, Kees de Hoogh
High resolution pollution maps are critical to understand the exposure and health effect of local residents to air pollution. Currently, none of the single technologies used to measure or estimate concentrations of pollutants can provide sufficient resolved exposure data. Land use regression (LUR) models were developed to combine ground-based measurements, satellite remote sensing (SRS) and air quality model (AQM), together with geographic and local source related spatial inputs, to generate high resolution pollution maps for both PM2...
April 15, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28411234/phenotype-of-gaba-transaminase-deficiency
#8
Mary Kay Koenig, Ryan Hodgeman, James J Riviello, Wendy Chung, Jennifer Bain, Claudia A Chiriboga, Kazushi Ichikawa, Hitoshi Osaka, Megumi Tsuji, K Michael Gibson, Penelope E Bonnen, Phillip L Pearl
OBJECTIVE: We report a case series of 10 patients with γ-aminobutyric acid (GABA)-transaminase deficiency including a novel therapeutic trial and an expanded phenotype. METHODS: Case ascertainment, literature review, comprehensive evaluations, and long-term treatment with flumazenil. RESULTS: All patients presented with neonatal or early infantile-onset encephalopathy; other features were hypotonia, hypersomnolence, epilepsy, choreoathetosis, and accelerated linear growth...
April 14, 2017: Neurology
https://www.readbyqxmd.com/read/28409595/exercise-prescriptions-in-older-adults
#9
Pearl Guozhu Lee, Elizabeth A Jackson, Caroline R Richardson
Regular physical activity and exercise are important for healthy aging and are beneficial for chronic disease management. Exercise prescriptions for older adults should account for the individual's health status and functional capacity. Any amount of exercise is better than being sedentary, even if health status prevents a person from achieving recommended goals. For most health outcomes, more benefits occur with physical activity performed at higher intensity, greater frequency, or longer duration. Guidelines recommend at least 150 minutes of moderate-intensity aerobic activity or 75 minutes of vigorous-intensity aerobic activity and at least two days of muscle-strengthening activities per week...
April 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28409506/characterization-of-cyclophilin-d-in-freshwater-pearl-mussel-hyriopsis-schlegelii
#10
Xiu-Xiu Liu, Cheng-Yuan Wang, Chun Luo, Jun-Qing Sheng, Di Wu, Bei-Juan Hu, Jun-Hua Wang, Yi-Jiang Hong
Cyclophilin D (referred to as HsCypD) was obtained from the freshwater pearl mussel (Hyriopsis schlegelii). The full-length cDNA was 2 671 bp, encoding a protein consisting of 367 amino acids. HsCypD was determined to be a hydrophilic intracellular protein with 10 phosphorylation sites and four tetratricopeptide repeat (TPR) domains, but no signal peptide. The core sequence region YKGCIFHRIIKDFMVQGG is highly conserved in vertebrates and invertebrates. Phylogenetic tree analysis indicated that CypD from all species had a common origin, and HsCypD had the closest phylogenetic relationship with CypD from Lottia gigantea...
March 18, 2017: Zoological Research
https://www.readbyqxmd.com/read/28409217/-surgical-techniques-for-treatment-of-vestibular-schwannoma
#11
S Rosahl, D Eßer
BACKGROUND: Microsurgical resection of vestibular schwannomas is demanding, even if not all of these tumors represent a challenge for experienced surgeons. In order to make the right decisions when it comes to balancing the extent of tumor resection with preservation of function, the surgeon must possess detailed knowledge of the surgical techniques and also have mastered these. OBJECTIVE: The current article describes the state-of-the-art of the three major microsurgical techniques for resection of vestibular schwannomas, their pearls and their perils...
April 13, 2017: HNO
https://www.readbyqxmd.com/read/28409106/open-bankart-revisited
#12
Ryan P Coughlin, Andrew Crapser, Kyrstin Coughlin, Larry P Coughlin
The surgical treatment of anterior shoulder instability can present a dilemma. Historically, an open Bankart repair was the benchmark solution. Over the last decade as surgeons became more arthroscopically savvy, the pendulum swung and a paradigm shift occurred. However, more recent studies have challenged this trend and, subsequently, revived interest in open repair. Thus, we feel it is critical to provide a more contemporary stepwise description of a procedure that has become essentially abandoned. The goal is to provide tips and pearls to achieve optimal exposure and, ultimately, a robust repair for a notoriously challenging operation...
February 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28407161/preliminary-evidence-of-successful-near-vision-enhancement-with-a-new-technique-presbyopic-allogenic-refractive-lenticule-pearl-corneal-inlay-using-a-smile-lenticule
#13
Soosan Jacob, Dhivya Ashok Kumar, Amar Agarwal, Athiya Agarwal, Ramalingam Aravind, A I Saijimol
PURPOSE: To describe a new technique (PrEsbyopic Allogenic Refractive Lenticule [PEARL] inlay) using an allogenic corneal inlay prepared from a small incision lenticule extraction (SMILE) lenticule. METHODS: A SMILE lenticule of specified thickness (mean: 61.5 ± 3.32 µm) was trephined at the center to 1-mm diameter and implanted in the cornea on the coaxially sighted light reflex under a femtosecond laser-created cap of 120 µm in the nondominant eye of presbyopic patients...
April 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28406610/advanced-absorption-correction-for-3d-elemental-images-applied-to-the-analysis-of-pearl-millet-seeds-obtained-with-a-laboratory-confocal-micro-x-ray-fluorescence-spectrometer
#14
Ioanna Mantouvalou, Tim Lachmann, Sudhir P Singh, Katarina Vogel-Mikus, Birgit Kanngiesser
We present a novel absorption correction approach for elemental distribution images obtained with a laboratory confocal micro X-ray fluorescence spectrometer. The procedure is suited especially for biological samples, as a constant dark matrix with a varying minor or trace element distribution is assumed. The constant absorption in the sample is extracted from depth dependent measurements. By using the concept of an effective excitation energy, depth-dependent and element-specific excitation energy values are calculated...
April 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28403619/insulin-like-growth-factor-is-associated-with-changes-in-body-composition-with-art-initiation
#15
Kristine M Erlandson, Suzanne P Fiorillo, Sandra Wagner Cardoso, Cynthia Rivere, Jorge Sanchez, James Hakim, Nagalingeswaran Kumarasamy, Sharlaa Badal-Fasesen, Umesh Lalloo, Johnstone J Kumwenda, Thomas B Campbell, Todd Brown
BACKGROUND: Growth hormone (GH)/insulin-like growth factor (IGF)-1 axis abnormalities have been associated with body composition changes among HIV-infected persons with wasting or lipodystrophy. Little is known of GH/IGF-1 axis alterations with ART initiation or differing ART therapies. METHODS: The AIDS Clinical Trials Group Prospective Evaluation of Antiretrovirals in Resource- Limited Settings (PEARLS) study was a prospective, randomized clinical trial of ART initiation with emtricitabine/tenofovir + efavirenz (FTC/TDF+EFV) vs lamivudine/zidovudine + efavirenz (3TC/ZDV+EFV) in HIV-1-infected individuals from resource-diverse settings...
April 12, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28401367/perfluoroalkyl-acids-pfaas-in-sediments-from-rivers-of-the-pearl-river-delta-southern-china
#16
Baolin Liu, Hong Zhang, Juying Li, Weihua Dong, Liuwei Xie
Having been largely used in industrial and household products, perfluoroalkyl acids (PFAAs) appear in environmental and biological systems with prevalence and persistence and have raised great concern in recent years. The present study is aimed at studying concentrations and composition profiles of 16 PFAAs in surface sediments collected from 51 sampling locations in 4 main rivers of the Pearl River Delta, one of the economy-developed areas in China. The total PFAA concentrations (∑ PFAAs) were determined in a wide range of 1...
May 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28393379/surveillance-neck-sonography-after-thyroidectomy-for-papillary-thyroid-carcinoma-pitfalls-in-the-diagnosis-of-locally-recurrent-and-metastatic-disease
#17
Wynne Yuru Chua, Jill E Langer, Lisa P Jones
A sonographic examination of the neck performed 6 to 12 months after thyroid surgery in patients with differentiated thyroid cancer is strongly recommended by the American Thyroid Association and considered mandatory by the European Thyroid Association for locoregional surveillance. The aim of this article is to review the normal anatomic changes expected after thyroid surgery and the pathologic mimics of thyroid carcinoma recurrence in post-thyroidectomy patients as they appear on neck sonography. We hope to offer some pearls to increase diagnostic confidence in this setting...
April 10, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28392384/hyriopsis-cumingii-hic52-a-novel-nacreous-layer-matrix-protein-with-a-collagen-like-structure
#18
Xiaojun Liu, Jingwen Pu, Shimei Zeng, Can Jin, Shaojian Dong, Jiale Li
Nacre is a product of a precisely regulated biomineralization process and a major contributor to the luster of pearls. Nacre is composed of calcium carbonate and an organic matrix of proteins that is secreted from mollusc mantle tissue and is exclusively associated with shell formation. In this study, hic52, a novel matrix protein gene from mantle of Hyriopsis cumingii, was cloned and functionally analyzed. The full-length cDNA of hic52 encoded 542 amino acids and contained a signal peptide of 18 amino acids...
April 6, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28392124/surgical-pathological-findings-in-type-1-and-2-endometrial-cancer-an-nrg-oncology-gynecologic-oncology-group-study-on-gog-210-protocol
#19
William T Creasman, Shamshad Ali, David G Mutch, Richard J Zaino, Matthew A Powell, Robert S Mannel, Floor J Backes, Paul A DiSilvestro, Peter A Argenta, Michael L Pearl, Shashikant B Lele, Saketh R Guntupalli, Steven Waggoner, Nick Spirtos, John F Boggess, Robert P Edwards, Virginia L Filiaci, David S Miller
OBJECTIVE: To report clinical and pathologic relationships with disease spread in endometrial cancer patients. METHODS: Surgical candidates with uterine cancer (adenocarcinoma or carcinosarcoma) who were eligible to participate in a surgical pathological study to create a clinically annotated tissue biorepository to support translational and clinical research studies. All patients were to undergo a hysterectomy, bilateral salpingo-oophorectomy, and bilateral pelvic and para-aortic lymphadenectomy...
April 6, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28380923/ultrafast-laser-induced-birefringence-in-various-porosity-silica-glasses-from-fused-silica-to-aerogel
#20
Ausra Cerkauskaite, Rokas Drevinskas, Alexey O Rybaltovskii, Peter G Kazansky
We compare a femtosecond laser induced modification in silica matrices with three different degrees of porosity. In single pulse regime, the decrease of substrate density from fused silica to high-silica porous glass and to silica aerogel glass results in tenfold increase of laser affected region with the formation of a symmetric cavity surrounded by the compressed silica shell with pearl like structures. In multi-pulse regime, if the cavity produced by the first pulse is relatively large, the subsequent pulses do not cause further modifications...
April 3, 2017: Optics Express
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