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JOURNAL ARTICLE
Moritz C Halfmann, Stefanie Bockius, Tilman Emrich, Michaela Hell, U Joseph Schoepf, Gerald S Laux, Larissa Kavermann, Dirk Graafen, Tomasso Gori, Yang Yang, Roman Kloeckner, Pál Maurovich-Horvat, Jens Ricke, Lukas Müller, Akos Varga-Szemes, Nicola Fink
Background Coronary CT angiography is a first-line test in coronary artery disease but is limited by severe calcifications. Photon-counting-detector (PCD) CT improves spatial resolution. Purpose To investigate the effect of improved spatial resolution on coronary stenosis assessment and reclassification. Materials and Methods Coronary stenoses were evaluated prospectively in a vessel phantom (in vitro) containing two stenoses (25%, 50%), and retrospectively in patients (in vivo) who underwent ultrahigh-spatial-resolution cardiac PCD CT (from July 2022 to April 2023)...
February 2024: Radiology
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JOURNAL ARTICLE
Nicholas J Smeeton, Johannes Meyer, Matyas Varga, Stefanie Klatt
Purpose : The aims of this study were to examine the learning of anticipation skill in the presence of kinematic and outcome probabilities information, and to see if this learning exhibited characteristics of Bayesian integration. Method : Participants with no competitive tennis playing experience watched tennis player stimuli playing forehand tennis shots and were tasked with predicted shot outcomes. Accuracy, response times and perceived task effort were recorded, pre, post and during four acquisition blocks where outcome feedback was provided...
February 7, 2024: Research Quarterly for Exercise and Sport
#3
JOURNAL ARTICLE
Elias V Wolf, Moritz C Halfmann, Akos Varga-Szemes, Nicola Fink, Roman Kloeckner, Stefanie Bockius, Thomas Allmendinger, Junia Hagenauer, Till Koehler, Karl-Friedrich Kreitner, U Joseph Schoepf, Thomas Münzel, Christoph Düber, Tommaso Gori, Yang Yang, Michaela M Hell, Tilman Emrich
Background: Calcium blooming causes stenosis overestimation on coronary CTA. Objective: To evaluate the impact of virtual monoenergetic imaging (VMI) reconstruction level on coronary artery stenosis quantification using a photon-counting detector (PCD) CT. Methods: A phantom containing two custom-made vessels (25% and 50% stenoses) underwent PCD CT acquisitions without and with simulated cardiac motion. A retrospective analysis was performed of 33 patients (7 female, 26 male; mean age, 71.3±9.0 years; 64 coronary artery stenoses) who underwent coronary CTA by PCD CT followed by invasive coronary angiography (ICA)...
January 10, 2024: AJR. American Journal of Roentgenology
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JOURNAL ARTICLE
Mohamed A Anany, Stefanie Haack, Isabell Lang, Julia Dahlhoff, Juan Gamboa Vargas, Tim Steinfatt, Lea Päckert, Daniela Weisenberger, Olena Zaitseva, Juliane Medler, Kirstin Kucka, Tengyu Zhang, Tom Van Belle, Luc van Rompaey, Andreas Beilhack, Harald Wajant
Background: Selective TNFR2 activation can be used to treat immune pathologies by activating and expanding regulatory T-cells (Tregs) but may also restore anti-tumour immunity by co-stimulating CD8+ T-cells. Oligomerized TNFR2-specific TNF mutants or anti-TNFR2 antibodies can activate TNFR2 but suffer either from poor production and pharmacokinetics or in the case of anti-TNFR2 antibodies typically from the need of FcγR binding to elicit maximal agonistic activity. Methods: To identify the major factor(s) determining FcγR-independent agonism of anti-TNFR2 antibodies, we systematically investigated a comprehensive panel of anti-TNFR2 antibodies and antibody-based constructs differing in the characteristics of their TNFR2 binding domains but also in the number and positioning of the latter...
2024: Theranostics
#5
JOURNAL ARTICLE
Alessandro Cagol, Pascal Benkert, Lester Melie-Garcia, Sabine A Schaedelin, Selina Leber, Charidimos Tsagkas, Muhamed Barakovic, Riccardo Galbusera, Po-Jui Lu, Matthias Weigel, Esther Ruberte, Ernst-Wilhelm Radue, Özgür Yaldizli, Johanna Oechtering, Johannes Lorscheider, Marcus D'Souza, Bettina Fischer-Barnicol, Stefanie Müller, Lutz Achtnichts, Jochen Vehoff, Giulio Disanto, Oliver Findling, Andrew Chan, Anke Salmen, Caroline Pot, Claire Bridel, Chiara Zecca, Tobias Derfuss, Johanna M Lieb, Luca Remonda, Franca Wagner, Maria Isabel Vargas, Renaud A Du Pasquier, Patrice H Lalive, Emanuele Pravatà, Johannes Weber, Philippe C Cattin, Martina Absinta, Claudio Gobbi, David Leppert, Ludwig Kappos, Jens Kuhle, Cristina Granziera
BACKGROUND AND OBJECTIVES: Progression independent of relapse activity (PIRA) is a crucial determinant of overall disability accumulation in multiple sclerosis (MS). Accelerated brain atrophy has been shown in patients experiencing PIRA. In this study, we assessed the relation between PIRA and neurodegenerative processes reflected by (1) longitudinal spinal cord atrophy and (2) brain paramagnetic rim lesions (PRLs). Besides, the same relationship was investigated in progressive MS (PMS)...
January 9, 2024: Neurology
#6
REVIEW
Prognostic Factors and Markers in Non-Small Cell Lung Cancer: Recent Progress and Future Challenges.
Débora Dummer Meira, Maria Clara de Castro E Caetano, Matheus Correia Casotti, Aléxia Stefani Siqueira Zetum, André Felipe Monteiro Gonçalves, André Rodrigues Moreira, Augusto Henrique de Oliveira, Fellipe Pesente, Gabriel Mendonça Santana, Daniel de Almeida Duque, Gierleson Santos Cangussu Pereira, Giulia de Souza Cupertino de Castro, Isabele Pagani Pavan, João Pedro Sarcinelli Chagas, José Henrique Borges Bourguignon, Juliana Ribeiro de Oliveira, Karen Ruth Michio Barbosa, Lorena Souza Castro Altoé, Luana Santos Louro, Luiza Poppe Merigueti, Lyvia Neves Rebello Alves, Marlon Ramos Rosado Machado, Maria Luísa Rodrigues Oliveira Roque, Pedro Santana Prates, Sayuri Honorio de Paula Segáua, Taissa Dos Santos Uchiya, Thomas Erik Santos Louro, Vinicius Eduardo Daleprane, Yasmin Moreto Guaitolini, Creuza Rachel Vicente, Raquel Silva Dos Reis Trabach, Bruno Cancian de Araújo, Eldamária de Vargas Wolfgramm Dos Santos, Flávia de Paula, Tiago José S Lopes, Elizeu Fagundes de Carvalho, Iúri Drumond Louro
Lung cancer is a highly aggressive neoplasm and, despite the development of recent therapies, tumor progression and recurrence following the initial response remains unsolved. Several questions remain unanswered about non-small cell lung cancer (NSCLC): (1) Which patients will actually benefit from therapy? (2) What are the predictive factors of response to MAbs and TKIs? (3) What are the best combination strategies with conventional treatments or new antineoplastic drugs? To answer these questions, an integrative literature review was carried out, searching articles in PUBMED, NCBI-PMC, Google Academic, and others...
October 4, 2023: Genes
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JOURNAL ARTICLE
Rodrigo Vargas-Vitoria, César Faúndez-Casanova, Alberto Cruz-Flores, Jordan Hernandez-Martinez, Stefany Jarpa-Preisler, Natalia Villar-Cavieres, María Teresa González-Muzzio, Lorena Garrido-González, Jorge Flández-Valderrama, Pablo Valdés-Badilla
This study protocol aims to analyze and compare the effects of combined movement and storytelling intervention (CMSI) on fundamental motor skills (locomotor skills and object control), language development (language comprehension, language expression, vocabulary and language description), and physical activity levels (light intensity, moderate-to-vigorous intensity and sedentary time) in children aged 3 to 6 years. The sample will consist of 144 children from 12 class groups, randomly assigned to 3 experimental groups ( n = 72 children) and 3 control groups ( n = 72 children), belonging to 4 class groups of upper-middle-level classes (2 experimental and 2 control; 3 to 4 years), 4 transition level 1 classes (2 experimental and 2 control; 4 to 5 years) and 4 transition level 2 classes (2 experimental and 2 control; 5 to 6 years)...
September 9, 2023: Children
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JOURNAL ARTICLE
Marcel S Woo, Friederike Ufer, Jana K Sonner, Anouar Belkacemi, Joseph Tintelnot, Pablo J Sáez, Paula F Krieg, Christina Mayer, Lars Binkle-Ladisch, Jan Broder Engler, Simone Bauer, Nina Kursawe, Vanessa Vieira, Stefanie Mannebach, Marc Freichel, Veit Flockerzi, Pablo Vargas, Manuel A Friese
Migratory dendritic cells (migDCs) continuously patrol tissues and are activated by injury and inflammation. Extracellular adenosine triphosphate (ATP) is released by damaged cells or actively secreted during inflammation and increases migDC motility. However, the underlying molecular mechanisms by which ATP accelerates migDC migration is not understood. Here, we show that migDCs can be distinguished from other DC subsets and immune cells by their expression of the voltage-gated calcium channel subunit β3 (Cavβ3; CACNB3), which exclusively facilitates ATP-dependent migration in vitro and during tissue damage in vivo...
September 22, 2023: Science Advances
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JOURNAL ARTICLE
Edson Guzmán-Calderón, Wilen Horacio Suárez-Ale, Leslie Chávez-Rimache, Luygy Zavaleta-Jara, Miguel José Díaz-Gonzales, Wilmer Gustavo Quiroga-Purizaca, Marco Terán-Choquehuanca, Víctor Moisés Lizarzaburu-Rodríguez, Sandra Graciela Vargas-Márquez, Héctor Juarez-Granda, Víctor Rodrigo Contreras-Quincho, Fernando Rómulo Revoredo-Rego, Oscar Miguel Merino-Chávez, Fredy Guillermo Coayla-Castillo, Víctor Velásquez-Rimachi, Sergio Goicochea-Lugo, Jonathan Mejía-Santiváñez, Álvaro Taype-Rondan, Stefany Salvador-Salvador, Vladimir Ernesto Santos-Sánchez
This article summarizes the clinical practice guideline (CPG) for the management of acute pancreatitis in the Social Security of Peru (EsSalud), to provide evidence-based clinical recommendations for the management of acute pancreatitis in EsSalud. A guideline development group (GEG) was formed that included medical specialists and methodologists. The GEG formulated 7 clinical questions to be answered by this CPG. Systematic searches of systematic reviews and -when considered relevant- primary studies were carried out in PubMed during 2022...
2023: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
#10
JOURNAL ARTICLE
Janaina Rigonato, Marko Budinich, Alejandro A Murillo, Manoela C Brandão, Juan J Pierella Karlusich, Yawouvi Dodji Soviadan, Ann C Gregory, Hisashi Endo, Florian Kokoszka, Dean Vik, Nicolas Henry, Paul Frémont, Karine Labadie, Ahmed A Zayed, Céline Dimier, Marc Picheral, Sarah Searson, Julie Poulain, Stefanie Kandels, Stéphane Pesant, Eric Karsenti, Peer Bork, Chris Bowler, Colomban de Vargas, Damien Eveillard, Marion Gehlen, Daniele Iudicone, Fabien Lombard, Hiroyuki Ogata, Lars Stemmann, Matthew B Sullivan, Shinichi Sunagawa, Patrick Wincker, Samuel Chaffron, Olivier Jaillon
For decades, marine plankton have been investigated for their capacity to modulate biogeochemical cycles and provide fishery resources. Between the sunlit (epipelagic) layer and the deep dark waters, lies a vast and heterogeneous part of the ocean: the mesopelagic zone. How plankton composition is shaped by environment has been well-explored in the epipelagic but much less in the mesopelagic ocean. Here, we conducted comparative analyses of trans-kingdom community assemblages thriving in the mesopelagic oxygen minimum zone (OMZ), mesopelagic oxic, and their epipelagic counterparts...
August 18, 2023: ISME Commun
#11
JOURNAL ARTICLE
Marco Maidana-Ojeda, Marta Alicia Fernández Gamarra, Guillermo Enciso, Pedro Chavez, Liliana Talavera Stefani, Gabriela Giuliana Caballero-Mairesse, Yeruti Mongelós-Franco, Andres Sanabria-Velazquez, Maria José Vargas, Cinthia Burgos-Cantoni, Lidia Quintana de Viedma, Horacio D Lopez-Nicora
Wheat ( Triticum aestivum ) is the third most cultivated field crop in Paraguay; it is grown on over 450,000 hectares with an annual production of 927,776 tons (fao.org/faostat). In 1952, Septoria tritici blotch (STB) was associated with the fungus Septoria tritici solely based on microscopic observation of conidia (Viedma and Delgado 1987). However, no morphometric or molecular studies have been performed in Paraguay up to date. Over the following decades, STB epidemic outbreaks were recorded, with a reduction in wheat production of up to 70% (Viedma and Delgado 1987)...
August 1, 2023: Plant Disease
#12
REVIEW
Lyvia Neves Rebello Alves, Débora Dummer Meira, Luiza Poppe Merigueti, Matheus Correia Casotti, Diego do Prado Ventorim, Jucimara Ferreira Figueiredo Almeida, Valdemir Pereira de Sousa, Marllon Cindra Sant'Ana, Rahna Gonçalves Coutinho da Cruz, Luana Santos Louro, Gabriel Mendonça Santana, Thomas Erik Santos Louro, Rhana Evangelista Salazar, Danielle Ribeiro Campos da Silva, Aléxia Stefani Siqueira Zetum, Raquel Silva Dos Reis Trabach, Flávia Imbroisi Valle Errera, Flávia de Paula, Eldamária de Vargas Wolfgramm Dos Santos, Elizeu Fagundes de Carvalho, Iúri Drumond Louro
Breast cancer is the second most frequent cancer in the world. It is a heterogeneous disease and the leading cause of cancer mortality in women. Advances in molecular technologies allowed for the identification of new and more specifics biomarkers for breast cancer diagnosis, prognosis, and risk prediction, enabling personalized treatments, improving therapy, and preventing overtreatment, undertreatment, and incorrect treatment. Several breast cancer biomarkers have been identified and, along with traditional biomarkers, they can assist physicians throughout treatment plan and increase therapy success...
June 28, 2023: Genes
#13
REVIEW
Matheus Correia Casotti, Débora Dummer Meira, Aléxia Stefani Siqueira Zetum, Bruno Cancian de Araújo, Danielle Ribeiro Campos da Silva, Eldamária de Vargas Wolfgramm Dos Santos, Fernanda Mariano Garcia, Flávia de Paula, Gabriel Mendonça Santana, Luana Santos Louro, Lyvia Neves Rebello Alves, Raquel Furlani Rocon Braga, Raquel Silva Dos Reis Trabach, Sara Santos Bernardes, Thomas Erik Santos Louro, Eduardo Cremonese Filippi Chiela, Guido Lenz, Elizeu Fagundes de Carvalho, Iúri Drumond Louro
Precision and organization govern the cell cycle, ensuring normal proliferation. However, some cells may undergo abnormal cell divisions (neosis) or variations of mitotic cycles (endopolyploidy). Consequently, the formation of polyploid giant cancer cells (PGCCs), critical for tumor survival, resistance, and immortalization, can occur. Newly formed cells end up accessing numerous multicellular and unicellular programs that enable metastasis, drug resistance, tumor recurrence, and self-renewal or diverse clone formation...
March 26, 2023: Genes
#14
JOURNAL ARTICLE
Manolo Fernández-Díaz, Angela Montalván-Avalos, Gisela Isasi-Rivas, Doris Villanueva-Pérez, Stefany Quiñones-Garcia, Luis Tataje-Lavanda, Dora Rios-Matos, Milagros Lulo-Vargas, Manolo Fernández-Sánchez, Luis A Guevara-Sarmiento, Mirko Zimic, Aldo Rojas-Neyra, Katherine Calderón
This study presents a draft genome sequence of a Newcastle disease virus (NDV) strain (VFAR-136) isolated from a fighting cock (Gallus gallus) in the south of Peru. Strain VFAR-136 is a new report of NDV genotype VII circulating in Peru.
January 31, 2023: Microbiology Resource Announcements
#15
JOURNAL ARTICLE
Alexandra Ramona Todea, Lester Melie-Garcia, Muhamed Barakovic, Alessandro Cagol, Reza Rahmanzadeh, Riccardo Galbusera, Po-Jui Lu, Matthias Weigel, Esther Ruberte, Ernst-Wilhelm Radue, Sabine Schaedelin, Pascal Benkert, Yaldizli Oezguer, Tim Sinnecker, Stefanie Müller, Lutz Achtnichts, Jochen Vehoff, Giulio Disanto, Oliver Findling, Andrew Chan, Anke Salmen, Caroline Pot, Patrice Lalive, Claire Bridel, Chiara Zecca, Tobias Derfuss, Luca Remonda, Franca Wagner, Maria Vargas, Renaud Du Pasquier, Emanuele Pravata, Johannes Weber, Claudio Gobbi, David Leppert, Jens Wuerfel, Tobias Kober, Benedicte Marechal, Ricardo Corredor-Jerez, Marios Psychogios, Johanna Lieb, Ludwig Kappos, Meritxell Bach Cuadra, Jens Kuhle, Cristina Granziera
BACKGROUND: Detecting new and enlarged lesions in multiple sclerosis (MS) patients is needed to determine their disease activity. LeMan-PV is a software embedded in the scanner reconstruction system of one vendor, which automatically assesses new and enlarged white matter lesions (NELs) in the follow-up of MS patients; however, multicenter validation studies are lacking. PURPOSE: To assess the accuracy of LeMan-PV for the longitudinal detection NEL white-matter MS lesions in a multicenter clinical setting...
January 28, 2023: Journal of Magnetic Resonance Imaging: JMRI
#16
JOURNAL ARTICLE
Juliana Andréa Dörr, Fernanda Majolo, Luísa Bortoluzzi, Evelin Zen de Vargas, Joana Silva, Manoela Pasini, Stefani Natali Stoll, Rafael Lopes da Rosa, Mariana Moreira Figueira, Márcio Fronza, Walter O Beys-da-Silva, Alice Martins, Helena Gaspar, Rui P Pedrosa, Stefan Laufer, Márcia Inês Goettert
Gastrointestinal diseases, such as peptic ulcers, are caused by a damage in the gastric mucosa provoked by several factors. This stomach injury is regulated by many inflammatory mediators and is commonly treated with proton-pump inhibitors, histamine H2 receptor blockers and antacids. However, various medicinal plants have demonstrated positive effects on gastric ulcer treatment, including plants of the Ceiba genus. The aim of this study was to evaluate the antiulcer and anti-inflammatory activities of the stem bark ethanolic extract of Ceiba speciosa (A...
December 9, 2022: International Journal of Molecular Sciences
#17
JOURNAL ARTICLE
Bence Daniel, Julia A Belk, Stefanie L Meier, Andy Y Chen, Katalin Sandor, Zsolt Czimmerer, Zsofia Varga, Krisztian Bene, Frank A Buquicchio, Yanyan Qi, Hugo Kitano, Joshua R Wheeler, Deshka S Foster, Michael Januszyk, Michael T Longaker, Howard Y Chang, Ansuman T Satpathy
Cell cycle (CC) facilitates cell division via robust, cyclical gene expression. Protective immunity requires the expansion of pathogen-responsive cell types, but whether CC confers unique gene expression programs that direct the subsequent immunological response remains unclear. Here, we demonstrate that single macrophages (MFs) adopt different plasticity states in CC, which leads to heterogeneous cytokine-induced polarization, priming, and repolarization programs. Specifically, MF plasticity to interferon gamma (IFNG) is substantially reduced during S-G2/M, whereas interleukin 4 (IL-4) induces S-G2/M-biased gene expression, mediated by CC-biased enhancers...
December 8, 2022: Molecular Cell
#18
JOURNAL ARTICLE
Andre Nicklas, Lisa-Marie Rückel, Benjamin Noël, Matyas Varga, Jens Kleinert, Martin Boss, Stefanie Klatt
Previous research has indicated that social interactions and gaze behavior analyses in a group setting could be essential tools in accomplishing group objectives. However, only a few studies have examined the impact of social interactions on group dynamics in team sports and their influence on team performance. This study aimed to investigate the effects of game performance pressure on the gaze behavior within social interactions between beach volleyball players during game-like situations. Therefore, 18 expert beach volleyball players conducted a high and a low game performance pressure condition while wearing an eye tracking system...
2022: Frontiers in Psychology
#19
JOURNAL ARTICLE
J Pierre Zila-Velasque, Pamela Grados-Espinoza, Kateriny Margot Regalado-Rodríguez, Cesia J Luna-Córdova, Gabriela Stefanie Sierra Calderón, Mills Diaz-Vargas, Cristian Diaz-Vélez, J Sifuentes-Rosales
INTRODUCTION: Eating disorders (ED) are serious conditions that have diverse consequences, associated with high morbidity and mortality: Among the factors associated with their development are, being female, and stress, which increased during the pandemic, and was higher in medical students. Our objective was to identify the prevalence and factors associated with ED in medical students. METHODS: Cross-sectional study, conducted with an online questionnaire, between January 1 and 31, 2021, in 22 universities, using the Eating Disorder Scale (EAT-26) and the Family Communication Scale (FCS)...
August 9, 2022: Revista Colombiana de Psiquiatría
#20
JOURNAL ARTICLE
Daniel J Richter, Romain Watteaux, Thomas Vannier, Jade Leconte, Paul Frémont, Gabriel Reygondeau, Nicolas Maillet, Nicolas Henry, Gaëtan Benoit, Ophélie Da Silva, Tom O Delmont, Antonio Fernàndez-Guerra, Samir Suweis, Romain Narci, Cédric Berney, Damien Eveillard, Frederick Gavory, Lionel Guidi, Karine Labadie, Eric Mahieu, Julie Poulain, Sarah Romac, Simon Roux, Céline Dimier, Stefanie Kandels, Marc Picheral, Sarah Searson, Stéphane Pesant, Jean-Marc Aury, Jennifer R Brum, Claire Lemaitre, Eric Pelletier, Peer Bork, Shinichi Sunagawa, Fabien Lombard, Lee Karp-Boss, Chris Bowler, Matthew B Sullivan, Eric Karsenti, Mahendra Mariadassou, Ian Probert, Pierre Peterlongo, Patrick Wincker, Colomban de Vargas, Maurizio Ribera d'Alcalà, Daniele Iudicone, Olivier Jaillon
Biogeographical studies have traditionally focused on readily visible organisms, but recent technological advances are enabling analyses of the large-scale distribution of microscopic organisms, whose biogeographical patterns have long been debated. Here we assessed the global structure of plankton geography and its relation to the biological, chemical, and physical context of the ocean (the 'seascape') by analyzing metagenomes of plankton communities sampled across oceans during the Tara Oceans expedition, in light of environmental data and ocean current transport...
August 3, 2022: ELife
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