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https://www.readbyqxmd.com/read/27878637/optimization-of-window-settings-for-standard-and-advanced-virtual-monoenergetic-imaging-in-abdominal-dual-energy-ct-angiography
#1
Damiano Caruso, Ashley H Parinella, U Joseph Schoepf, Maxwell H Stroebel, Stefanie Mangold, Julian L Wichmann, Akos Varga-Szemes, B Devon Ball, Domenico De Santis, Andrea Laghi, Carlo N De Cecco
OBJECTIVES: To determine the optimal window setting for displaying virtual monoenergetic reconstructions of third generation dual-source, dual-energy CT (DECT) angiography of the abdomen. METHODS: Forty-five patients were evaluated with DECT angiography (90/150 kV, 180/90 ref. mAs). Three datasets were reconstructed: standard linear blending (M_0.6), 70 keV traditional virtual monoenergetic (M70), and 40 keV advanced noise-optimized virtual monoenergetic (M40+)...
November 23, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27872472/hierarchical-effects-of-pro-inflammatory-cytokines-on-the-post-influenza-susceptibility-to-pneumococcal-coinfection
#2
Stefanie Duvigneau, Niharika Sharma-Chawla, Alessandro Boianelli, Sabine Stegemann-Koniszewski, Van Kinh Nguyen, Dunja Bruder, Esteban A Hernandez-Vargas
In the course of influenza A virus (IAV) infections, a secondary bacterial infection frequently leads to serious respiratory conditions provoking high hospitalization and death tolls. Although abundant pro-inflammatory responses have been reported as key contributing factors for these severe dual infections, the relative contributions of cytokines remain largely unclear. In the current study, mathematical modelling based on murine experimental data dissects IFN-γ as a cytokine candidate responsible for impaired bacterial clearance, thereby promoting bacterial growth and systemic dissemination during acute IAV infection...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27815347/the-first-scube3-mutant-mouse-line-with-pleiotropic-phenotypic-alterations
#3
Helmut Fuchs, Sibylle Sabrautzki, Gerhard K H Przemeck, Stefanie Leuchtenberger, Bettina Lorenz-Depiereux, Lore Becker, Birgit Rathkolb, Marion Horsch, Lillian Garrett, Manuela A Östereicher, Wolfgang Hans, Koichiro Abe, Nobuho Sagawa, Jan Rozman, Ingrid L Vargas-Panesso, Michael Sandholzer, Thomas S Lisse, Thure Adler, Juan Antonio Aguilar-Pimentel, Julia Calzada-Wack, Nicole Ehrhard, Ralf Elvert, Christine Gau, Sabine M Hölter, Katja Micklich, Kristin Moreth, Cornelia Prehn, Oliver Puk, Ildiko Racz, Claudia Stoeger, Alexandra Vernaleken, Dian Michel, Susanne Diener, Thomas Wieland, Jerzy Adamski, Raffi Bekeredjian, Dirk H Busch, John Favor, Jochen Graw, Martin Klingenspor, Christoph Lengger, Holger Maier, Frauke Neff, Markus Ollert, Tobias Stoeger, Ali Önder Yildirim, Tim M Strom, Andreas Zimmer, Eckhard Wolf, Wolfgang Wurst, Thomas Klopstock, Johannes Beckers, Valerie Gailus-Durner, Martin Hrabě de Angelis
The vertebrate Scube (Signal peptide, CUB and EGF-like domain-containing protein) family consists of three independent members Scube1-3, which encode secreted cell surface-associated membrane glycoproteins. Limited information about the general function of this gene family is available, and their roles during adulthood. Here, we present the first Scube3 mutant mouse line (Scube3(N294K/N294K)) that clearly shows phenotypic alterations by carrying a missense mutation in exon 8, and thus contributes to understand SCUBE3 functions...
November 4, 2016: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/27716572/trait-and-state-rumination-interact-to-prolong-cortisol-activation-to-psychosocial-stress-in-females
#4
Alexa Shull, Stefanie E Mayer, Ellen McGinnis, Elisa Geiss, Ivan Vargas, Nestor L Lopez-Duran
There is a growing realization that cognitive processes associated with stress coping, such as rumination and distraction, can impact the hypothalamic-pituitary-adrenal-axis (HPA-axis). Yet, little is known about what aspects of the HPA-axis stress response (rate of activation, duration of activation, rate of recovery) is impacted by such cognitive processes. This study examines the impact of both ruminative trait tendencies and experimentally induced rumination on salivary cortisol responses to a social evaluative stress task...
September 20, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27690324/t-rho-and-magnetization-transfer-and-inversion-recovery-traminer-prepared-imaging-a-novel-contrast-enhanced-flow-independent-dark-blood-technique-for-the-evaluation-of-myocardial-late-gadolinium-enhancement-in-patients-with-myocardial-infarction
#5
Giuseppe Muscogiuri, Wolfgang G Rehwald, U Joseph Schoepf, Pal Suranyi, Sheldon E Litwin, Carlo N De Cecco, Julian L Wichmann, Stefanie Mangold, Damiano Caruso, Stephen R Fuller, Richard R Bayer 2nd, Akos Varga-Szemes
PURPOSE: To evaluate a new dark-blood late gadolinium enhancement (LGE) technique called "T(Rho) And Magnetization transfer and INvErsion Recovery" (TRAMINER) for the ability to detect myocardial LGE versus standard "bright-blood" inversion recovery (SIR) imaging. MATERIALS AND METHODS: This Institutional Review Board (IRB)-approved, Health Insurance Portability and Accountability Act (HIPAA)-compliant prospective study included 40 patients (62 ± 14 years [mean ± standard deviation (SD)], 29 males) with suspected myocardial infarction (MI) referred for the assessment of myocardial viability...
September 30, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27682312/diagnostic-accuracy-of-coronary-ct-angiography-using-3-rd-generation-dual-source-ct-and-automated-tube-voltage-selection-clinical-application-in-a-non-obese-and-obese-patient-population
#6
Stefanie Mangold, Julian L Wichmann, U Joseph Schoepf, Damiano Caruso, Christian Tesche, Daniel H Steinberg, Akos Varga-Szemes, Andrew C Stubenrauch, Richard R Bayer, Matthew Biancalana, Konstantin Nikolaou, Carlo N De Cecco
PURPOSE: To investigate diagnostic accuracy of 3(rd)-generation dual-source CT (DSCT) coronary angiography in obese and non-obese patients. METHODS: We retrospectively analyzed 76 patients who underwent coronary CT angiography (CCTA) and invasive coronary angiography. Prospectively ECG-triggered acquisition was performed with automated tube voltage selection (ATVS). Patients were dichotomized based on body mass index in groups A (<30 kg/m(2), n = 37) and B (≥30 kg/m(2), n = 39) and based on tube voltage in groups C (<120 kV, n = 46) and D (120 kV, n = 30)...
September 28, 2016: European Radiology
https://www.readbyqxmd.com/read/27671791/viable-ednra-y129f-mice-feature-human-mandibulofacial-dysostosis-with-alopecia-mfda-syndrome-due-to-the-homologue-mutation
#7
Sibylle Sabrautzki, Michael A Sandholzer, Bettina Lorenz-Depiereux, Robert Brommage, Gerhard Przemeck, Ingrid L Vargas Panesso, Alexandra Vernaleken, Lillian Garrett, Katharina Baron, Ali O Yildirim, Jan Rozman, Birgit Rathkolb, Christine Gau, Wolfgang Hans, Sabine M Hoelter, Susan Marschall, Claudia Stoeger, Lore Becker, Helmut Fuchs, Valerie Gailus-Durner, Martin Klingenspor, Thomas Klopstock, Christoph Lengger, Leuchtenberger Stefanie, Eckhard Wolf, Tim M Strom, Wolfgang Wurst, Martin Hrabě de Angelis
Animal models resembling human mutations are valuable tools to research the features of complex human craniofacial syndromes. This is the first report on a viable dominant mouse model carrying a non-synonymous sequence variation within the endothelin receptor type A gene (Ednra c.386A>T, p.Tyr129Phe) derived by an ENU mutagenesis program. The identical amino acid substitution was reported recently as disease causing in three individuals with the mandibulofacial dysostosis with alopecia (MFDA, OMIM 616367) syndrome...
December 2016: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/27614365/correction-factors-for-ct-coronary-artery-calcium-scoring-using-advanced-modeled-iterative-reconstruction-instead-of-filtered-back-projection
#8
Damiano Caruso, Carlo N De Cecco, U Joseph Schoepf, Lloyd M Felmly, Akos Varga-Szemes, Stefanie Mangold, Christian Canstein, Thomas Allmendinger, Stephen R Fuller, Andrea Laghi, Julian L Wichmann
RATIONALE AND OBJECTIVES: Iterative reconstruction (IR) computed tomography (CT) techniques allow for radiation dose reduction while maintaining image quality. However, CT coronary artery calcium (CAC) scores may be influenced by certain IR algorithms. The aim of our study is to identify suitable correction factors to ensure consistency between IR and filtered back projection (FBP)-based CAC scoring. MATERIAL AND METHODS: A phantom study was performed to derive suitable correction factors for CAC scores and volume (VOL) values with advanced modeled iterative reconstruction (or ADMIRE) strength level 3 (ADM3) and 5 (ADM5) vs FBP...
September 7, 2016: Academic Radiology
https://www.readbyqxmd.com/read/27553939/low-contrast-medium-volume-third-generation-dual-source-computed-tomography-angiography-for-transcatheter-aortic-valve-replacement-planning
#9
Lloyd M Felmly, Carlo N De Cecco, U Joseph Schoepf, Akos Varga-Szemes, Stefanie Mangold, Andrew D McQuiston, Sheldon E Litwin, Richard R Bayer, Thomas J Vogl, Julian L Wichmann
PURPOSE: To investigate feasibility, image quality and safety of low-tube-voltage, low-contrast-volume comprehensive cardiac and aortoiliac CT angiography (CTA) for planning transcatheter aortic valve replacement (TAVR). MATERIALS AND METHODS: Forty consecutive TAVR candidates prospectively underwent combined CTA of the aortic root and vascular access route (270 mgI/ml iodixanol). Patients were assigned to group A (second-generation dual-source CT [DSCT], 100 kV, 60 ml contrast, 4...
August 23, 2016: European Radiology
https://www.readbyqxmd.com/read/27522516/first-international-consensus-conference-on-lesions-of-uncertain-malignant-potential-in-the-breast-b3-lesions
#10
REVIEW
Christoph J Rageth, Elizabeth Am O'Flynn, Christopher Comstock, Claudia Kurtz, Rahel Kubik, Helmut Madjar, Domenico Lepori, Gert Kampmann, Alexander Mundinger, Astrid Baege, Thomas Decker, Stefanie Hosch, Christoph Tausch, Jean-François Delaloye, Elisabeth Morris, Zsuzsanna Varga
The purpose of this study is to obtain a consensus for the therapy of B3 lesions. The first International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions) including atypical ductal hyperplasia (ADH), flat epithelial atypia (FEA), classical lobular neoplasia (LN), papillary lesions (PL), benign phyllodes tumors (PT), and radial scars (RS) took place in January 2016 in Zurich, Switzerland organized by the International Breast Ultrasound School and the Swiss Minimally Invasive Breast Biopsy group-a subgroup of the Swiss Society of Senology...
September 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27510361/dynamic-ct-myocardial-perfusion-imaging
#11
Damiano Caruso, Marwen Eid, U Joseph Schoepf, Kwang Nam Jin, Akos Varga-Szemes, Christian Tesche, Stefanie Mangold, Adam Spandorfer, Andrea Laghi, Carlo N De Cecco
Non-invasive cardiac imaging has rapidly evolved during the last decade due to advancements in CT based technologies. Coronary CT angiography has been shown to reliably assess coronary anatomy and detect high risk coronary artery disease. However, this technique is limited to anatomical assessment, thus non-invasive techniques for functional assessment of the heart are necessary. CT myocardial perfusion is a new CT based technique that provides functional assessment of the myocardium and allows for a comprehensive assessment of coronary artery disease with a single modality when combined with CTA...
October 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27465684/the-cortisol-awakening-response-and-depressive-symptomatology-the-moderating-role-of-sleep-and-gender
#12
Ivan Vargas, Stefanie Mayer, Nestor Lopez-Duran
The association between depression and the cortisol awakening response (CAR) has been widely examined, yet the results are mixed and factors responsible for such inconsistencies are poorly understood. The current study investigated whether the link between depressive symptomatology and CAR varied as a function of two such factors: sleep and gender. The sample included 58 young adults (30 females; Mage  = 18.7; SDage  = 0.91). Participants completed the Beck Depression Inventory as well as the Consensus Sleep Diary to assess depressive symptomatology and daily sleep patterns, respectively...
July 28, 2016: Stress and Health: Journal of the International Society for the Investigation of Stress
https://www.readbyqxmd.com/read/27165140/single-and-dual-energy-ct-of-the-abdomen-comparison-of-radiation-dose-and-image-quality-of-2nd-and-3rd-generation-dual-source-ct
#13
Julian L Wichmann, Andrew D Hardie, U Joseph Schoepf, Lloyd M Felmly, Jonathan D Perry, Akos Varga-Szemes, Stefanie Mangold, Damiano Caruso, Christian Canstein, Thomas J Vogl, Carlo N De Cecco
OBJECTIVES: To compare single-energy (SECT) and dual-energy (DECT) abdominal CT examinations in matched patient cohorts regarding differences in radiation dose and image quality performed with second- and third-generation dual-source CT (DSCT). METHODS: We retrospectively analysed 200 patients (100 male, 100 female; mean age 61.2 ± 13.5 years, mean body mass index 27.5 ± 3.8 kg/m(2)) equally divided into four groups matched by gender and body mass index, who had undergone portal venous phase abdominal CT with second-generation (group A, 120-kV-SECT; group B, 80/140-kV-DECT) and third-generation DSCT (group C, 100-kV-SECT; group D, 90/150-kV-DECT)...
May 10, 2016: European Radiology
https://www.readbyqxmd.com/read/27130058/effect-of-automated-tube-voltage-selection-integrated-circuit-detector-and-advanced-iterative-reconstruction-on-radiation-dose-and-image-quality-of-3rd-generation-dual-source-aortic-ct-angiography-an-intra-individual-comparison
#14
Stefanie Mangold, Carlo N De Cecco, Julian L Wichmann, Christian Canstein, Akos Varga-Szemes, Damiano Caruso, Stephen R Fuller, Fabian Bamberg, Konstantin Nikolaou, U Joseph Schoepf
PURPOSE: To compare, on an intra-individual basis, the effect of automated tube voltage selection (ATVS), integrated circuit detector and advanced iterative reconstruction on radiation dose and image quality of aortic CTA studies using 2nd and 3rd generation dual-source CT (DSCT). MATERIAL AND METHODS: We retrospectively evaluated 32 patients who had undergone CTA of the entire aorta with both 2nd generation DSCT at 120kV using filtered back projection (FBP) (protocol 1) and 3rd generation DSCT using ATVS, an integrated circuit detector and advanced iterative reconstruction (protocol 2)...
May 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/26993434/coronary-ct-angiography-derived-morphological-and-functional-quantitative-plaque-markers-correlated-with-invasive-fractional-flow-reserve-for-detecting-hemodynamically-significant-stenosis
#15
Christian Tesche, Carlo N De Cecco, Damiano Caruso, Stefan Baumann, Matthias Renker, Stefanie Mangold, Kevin T Dyer, Akos Varga-Szemes, Moritz Baquet, David Jochheim, Ullrich Ebersberger, Richard R Bayer, Ellen Hoffmann, Daniel H Steinberg, U Joseph Schoepf
OBJECTIVE: Compare morphological and functional coronary plaque markers derived from coronary CT angiography (CCTA) for their ability to detect lesion-specific ischemia. MATERIALS AND METHODS: Data of patients who had undergone both dual-source CCTA and invasive fractional flow reserve (FFR) measurement within 3 months were retrospectively analyzed. Various quantitative stenosis markers were derived from CCTA: Corrected coronary opacification (CCO), transluminal attenuation gradient (TAG), remodeling index (RI), computational FFR (cFFR), lesion length (LL), vessel volume (VV), total plaque volume (TPV), and calcified and non-calcified plaque volume (CPV and NCPV)...
May 2016: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/26960541/a-noise-optimized-virtual-monochromatic-reconstruction-algorithm-improves-stent-visualization-and-diagnostic-accuracy-for-detection-of-in-stent-re-stenosis-in-lower-extremity-run-off-ct-angiography
#16
Stefanie Mangold, Carlo N De Cecco, U Joseph Schoepf, Ricardo T Yamada, Akos Varga-Szemes, Andrew C Stubenrauch, Damiano Caruso, Stephen R Fuller, Thomas J Vogl, Konstantin Nikolaou, Thomas M Todoran, Julian L Wichmann
PURPOSE: To evaluate the impact of noise-optimized virtual monochromatic imaging (VMI+) on stent visualization and accuracy for in-stent re-stenosis at lower extremity dual-energy CT angiography (DE-CTA). MATERIAL AND METHODS: We evaluated third-generation dual-source DE-CTA studies in 31 patients with prior stent placement. Images were reconstructed with linear blending (F_0.5) and VMI+ at 40-150 keV. In-stent luminal diameter was measured and contrast-to-noise ratio (CNR) calculated...
March 9, 2016: European Radiology
https://www.readbyqxmd.com/read/26863193/plankton-networks-driving-carbon-export-in-the-oligotrophic-ocean
#17
Lionel Guidi, Samuel Chaffron, Lucie Bittner, Damien Eveillard, Abdelhalim Larhlimi, Simon Roux, Youssef Darzi, Stephane Audic, Léo Berline, Jennifer R Brum, Luis Pedro Coelho, Julio Cesar Ignacio Espinoza, Shruti Malviya, Shinichi Sunagawa, Céline Dimier, Stefanie Kandels-Lewis, Marc Picheral, Julie Poulain, Sarah Searson, Lars Stemmann, Fabrice Not, Pascal Hingamp, Sabrina Speich, Mick Follows, Lee Karp-Boss, Emmanuel Boss, Hiroyuki Ogata, Stephane Pesant, Jean Weissenbach, Patrick Wincker, Silvia G Acinas, Peer Bork, Colomban de Vargas, Daniele Iudicone, Matthew B Sullivan, Jeroen Raes, Eric Karsenti, Chris Bowler, Gabriel Gorsky
The biological carbon pump is the process by which CO2 is transformed to organic carbon via photosynthesis, exported through sinking particles, and finally sequestered in the deep ocean. While the intensity of the pump correlates with plankton community composition, the underlying ecosystem structure driving the process remains largely uncharacterized. Here we use environmental and metagenomic data gathered during the Tara Oceans expedition to improve our understanding of carbon export in the oligotrophic ocean...
April 28, 2016: Nature
https://www.readbyqxmd.com/read/26847044/automated-tube-voltage-selection-for-radiation-dose-and-contrast-medium-reduction-at-coronary-ct-angiography-using-3-rd-generation-dual-source-ct
#18
Stefanie Mangold, Julian L Wichmann, U Joseph Schoepf, Zachary B Poole, Christian Canstein, Akos Varga-Szemes, Damiano Caruso, Fabian Bamberg, Konstantin Nikolaou, Carlo N De Cecco
OBJECTIVES: To investigate the relationship between automated tube voltage selection (ATVS) and body mass index (BMI) and its effect on image quality and radiation dose of coronary CT angiography (CCTA). METHODS: We evaluated 272 patients who underwent CCTA with 3(rd) generation dual-source CT (DSCT). Prospectively ECG-triggered spiral acquisition was performed with automated tube current selection and advanced iterative reconstruction. Tube voltages were selected by ATVS (70-120 kV)...
October 2016: European Radiology
https://www.readbyqxmd.com/read/26843805/the-healthy-community-neighborhood-initiative-rationale-and-design
#19
Arleen F Brown, D'Ann M Morris, Katherine L Kahn, Ibrahima C Sankaré, Keyonna M King, Roberto Vargas, Aziza Lucas-Wright, Loretta F Jones, Astrea Flowers, Felica U Jones, Rachelle Bross, Dennishia Banner, Homero E Del Pino, Orwilda L Pitts, Lujia Zhang, Courtney Porter, Sigrid K Madrigal, Stefanie D Vassar, Sitaram Vangala, Li-Jung Liang, Arturo B Martinez, Keith C Norris
OBJECTIVE: To describe the design and rationale of the Healthy Community Neighborhood Initiative (HCNI), a multi-component study to understand and document health risk and resources in a low-income and minority community. DESIGN: A community-partnered participatory research project. SETTING: A low-income, biethnic African American and Latino neighborhood in South Los Angeles. PARTICIPANTS: Adult community residents aged >18 years...
2016: Ethnicity & Disease
https://www.readbyqxmd.com/read/26768740/vascular-imaging-before-transcatheter-aortic-valve-replacement-tavr-why-and-how
#20
Damiano Caruso, Russell D Rosenberg, Carlo N De Cecco, Stefanie Mangold, Julian L Wichmann, Akos Varga-Szemes, Daniel H Steinberg, Andrea Laghi, U Joseph Schoepf
Transcatheter aortic valve replacement (TAVR) has become an alternative to surgical intervention for symptomatic or severe aortic valve stenosis in patients with high surgical risk. Successful TAVR requires a multimodality imaging approach for appropriate patient selection and prosthesis sizing. Here, we describe individual imaging modalities and report their respective roles in this emerging field. To date, echocardiography remains the traditional test for determining patient candidacy and prosthesis selection, but computed tomography (CT) has been taking on an increasingly important role in the evaluation of both the aortic root anatomy and aortoiliofemoral vessels as a single examination...
February 2016: Current Cardiology Reports
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