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Damiano Caruso, Marwen Eid, U Joseph Schoepf, Domenico De Santis, Akos Varga-Szemes, Stefanie Mangold, Christian Canstein, Virginia W Lesslie, Stephen R Fuller, B Devon Ball, Andrea Laghi, Carlo N De Cecco
OBJECTIVES: The aim of this study was to investigate the minimum iodine delivery rate (IDR) and contrast media (CM) volume required for diagnostic contrast enhancement of 350 HU (Hounsfield units) in the ascending aorta at different kV settings. METHODS: Dynamic computed tomography acquisitions from 70 to 150 kV were performed in a circulation phantom. First, injections with IDR ranging from 0.1 to 2.0 g I/s were tested for each kV. In the second part, the IDR was held constant, whereas the CM volume was reduced from 50 to 10 mL...
April 26, 2017: Journal of Computer Assisted Tomography
#2
Thomas R Webb, Jeanette Erdmann, Kathleen E Stirrups, Nathan O Stitziel, Nicholas G D Masca, Henning Jansen, Stavroula Kanoni, Christopher P Nelson, Paola G Ferrario, Inke R König, John D Eicher, Andrew D Johnson, Stephen E Hamby, Christer Betsholtz, Arno Ruusalepp, Oscar Franzén, Eric E Schadt, Johan L M Björkegren, Peter E Weeke, Paul L Auer, Ursula M Schick, Yingchang Lu, He Zhang, Marie-Pierre Dube, Anuj Goel, Martin Farrall, Gina M Peloso, Hong-Hee Won, Ron Do, Erik van Iperen, Jochen Kruppa, Anubha Mahajan, Robert A Scott, Christina Willenborg, Peter S Braund, Julian C van Capelleveen, Alex S F Doney, Louise A Donnelly, Rosanna Asselta, Pier A Merlini, Stefano Duga, Nicola Marziliano, Josh C Denny, Christian Shaffer, Nour Eddine El-Mokhtari, Andre Franke, Stefanie Heilmann, Christian Hengstenberg, Per Hoffmann, Oddgeir L Holmen, Kristian Hveem, Jan-Håkan Jansson, Karl-Heinz Jöckel, Thorsten Kessler, Jennifer Kriebel, Karl L Laugwitz, Eirini Marouli, Nicola Martinelli, Mark I McCarthy, Natalie R Van Zuydam, Christa Meisinger, Tõnu Esko, Evelin Mihailov, Stefan A Escher, Maris Alver, Susanne Moebus, Andrew D Morris, Jarma Virtamo, Majid Nikpay, Oliviero Olivieri, Sylvie Provost, Alaa AlQarawi, Neil R Robertson, Karen O Akinsansya, Dermot F Reilly, Thomas F Vogt, Wu Yin, Folkert W Asselbergs, Charles Kooperberg, Rebecca D Jackson, Eli Stahl, Martina Müller-Nurasyid, Konstantin Strauch, Tibor V Varga, Melanie Waldenberger, Lingyao Zeng, Rajiv Chowdhury, Veikko Salomaa, Ian Ford, J Wouter Jukema, Philippe Amouyel, Jukka Kontto, Børge G Nordestgaard, Jean Ferrières, Danish Saleheen, Naveed Sattar, Praveen Surendran, Aline Wagner, Robin Young, Joanna M M Howson, Adam S Butterworth, John Danesh, Diego Ardissino, Erwin P Bottinger, Raimund Erbel, Paul W Franks, Domenico Girelli, Alistair S Hall, G Kees Hovingh, Adnan Kastrati, Wolfgang Lieb, Thomas Meitinger, William E Kraus, Svati H Shah, Ruth McPherson, Marju Orho-Melander, Olle Melander, Andres Metspalu, Colin N A Palmer, Annette Peters, Daniel J Rader, Muredach P Reilly, Ruth J F Loos, Alex P Reiner, Dan M Roden, Jean-Claude Tardif, John R Thompson, Nicholas J Wareham, Hugh Watkins, Cristen J Willer, Nilesh J Samani, Heribert Schunkert, Panos Deloukas, Sekar Kathiresan
BACKGROUND: Genome-wide association studies have so far identified 56 loci associated with risk of coronary artery disease (CAD). Many CAD loci show pleiotropy; that is, they are also associated with other diseases or traits. OBJECTIVES: This study sought to systematically test if genetic variants identified for non-CAD diseases/traits also associate with CAD and to undertake a comprehensive analysis of the extent of pleiotropy of all CAD loci. METHODS: In discovery analyses involving 42,335 CAD cases and 78,240 control subjects we tested the association of 29,383 common (minor allele frequency >5%) single nucleotide polymorphisms available on the exome array, which included a substantial proportion of known or suspected single nucleotide polymorphisms associated with common diseases or traits as of 2011...
February 21, 2017: Journal of the American College of Cardiology
#3
Akos Varga-Szemes, Rob J van der Geest, U Joseph Schoepf, Bruce S Spottiswoode, Carlo N De Cecco, Giuseppe Muscogiuri, Julian L Wichmann, Stefanie Mangold, Stephen R Fuller, Pal Maurovich-Horvat, Bela Merkely, Sheldon E Litwin, Rozemarijn Vliegenthart, Pal Suranyi
OBJECTIVES: To evaluate the influence of inversion time (TI) on the precision of myocardial late gadolinium enhancement (LGE) quantification using synthetic inversion recovery (IR) imaging in patients with myocardial infarction (MI). METHODS: Fifty-three patients with suspected prior MI underwent 1.5-T cardiac MRI with conventional magnitude (MagIR) and phase-sensitive IR (PSIR) LGE imaging and T1 mapping at 15 min post-contrast. T1-based synthetic MagIR and PSIR images were calculated with a TI ranging from -100 to +150 ms at 5-ms intervals relative to the optimal TI (TI0)...
January 3, 2017: European Radiology
#4
Stefanie Mangold, Carlo N De Cecco, U Joseph Schoepf, Taylor S Kuhlman, Akos Varga-Szemes, Damiano Caruso, Taylor M Duguay, Christian Tesche, Thomas J Vogl, Konstantin Nikolaou, Daniel H Steinberg, Julian L Wichmann
PURPOSE: To assess image quality and accuracy of CT angiography (CTA) for transcatheter aortic valve replacement (TAVR) planning performed with 3rd generation dual-source CT (DSCT). MATERIAL AND METHODS: We evaluated 125 patients who underwent TAVR-planning CTA on 3rd generation DSCT. A two-part protocol was performed including retrospectively ECG-gated coronary CTA (CCTA) and prospectively ECG-triggered aortoiliac CTA using 60mL of contrast medium. Automated tube voltage selection and advanced iterative reconstruction were applied...
January 2017: European Journal of Radiology
#5
Matheus D Baldissera, Carine F Souza, Guerino B Júnior, Agueda C de Vargas, Aline A Boligon, Marli M A de Campos, Lenita M Stefani, Bernardo Baldisserotto
The aim of this study was to evaluate the effects of M. alternifolia essential oil used to treat silver catfish (Rhamdia quelen) experimentally infected by Aeromonas hydrophila on oxidative stress variables, and for the first time, on hepatic enzymes of the cholinergic and adenosinergic systems. For that, fish were divided into six groups (A-F), each containing seven animals. Groups A, B and C were composed of uninfected animals, while animals in groups D, E and F were intramuscularly inoculated with A. hydrophila...
February 2017: Fish & Shellfish Immunology
#6
Damiano Caruso, Ashley H Parinella, U Joseph Schoepf, Maxwell H Stroebel, Stefanie Mangold, Julian L Wichmann, Akos Varga-Szemes, B Devon Ball, Domenico De Santis, Andrea Laghi, Carlo N De Cecco
OBJECTIVES: To determine the optimal window setting for displaying virtual monoenergetic reconstructions of third generation dual-source, dual-energy CT (DECT) angiography of the abdomen. METHODS: Forty-five patients were evaluated with DECT angiography (90/150 kV, 180/90 ref. mAs). Three datasets were reconstructed: standard linear blending (M_0.6), 70 keV traditional virtual monoenergetic (M70), and 40 keV advanced noise-optimized virtual monoenergetic (M40+)...
November 23, 2016: Abdominal Radiology
#7
Stefanie Duvigneau, Niharika Sharma-Chawla, Alessandro Boianelli, Sabine Stegemann-Koniszewski, Van Kinh Nguyen, Dunja Bruder, Esteban A Hernandez-Vargas
In the course of influenza A virus (IAV) infections, a secondary bacterial infection frequently leads to serious respiratory conditions provoking high hospitalization and death tolls. Although abundant pro-inflammatory responses have been reported as key contributing factors for these severe dual infections, the relative contributions of cytokines remain largely unclear. In the current study, mathematical modelling based on murine experimental data dissects IFN-γ as a cytokine candidate responsible for impaired bacterial clearance, thereby promoting bacterial growth and systemic dissemination during acute IAV infection...
November 22, 2016: Scientific Reports
#8
Helmut Fuchs, Sibylle Sabrautzki, Gerhard K H Przemeck, Stefanie Leuchtenberger, Bettina Lorenz-Depiereux, Lore Becker, Birgit Rathkolb, Marion Horsch, Lillian Garrett, Manuela A Östereicher, Wolfgang Hans, Koichiro Abe, Nobuho Sagawa, Jan Rozman, Ingrid L Vargas-Panesso, Michael Sandholzer, Thomas S Lisse, Thure Adler, Juan Antonio Aguilar-Pimentel, Julia Calzada-Wack, Nicole Ehrhard, Ralf Elvert, Christine Gau, Sabine M Hölter, Katja Micklich, Kristin Moreth, Cornelia Prehn, Oliver Puk, Ildiko Racz, Claudia Stoeger, Alexandra Vernaleken, Dian Michel, Susanne Diener, Thomas Wieland, Jerzy Adamski, Raffi Bekeredjian, Dirk H Busch, John Favor, Jochen Graw, Martin Klingenspor, Christoph Lengger, Holger Maier, Frauke Neff, Markus Ollert, Tobias Stoeger, Ali Önder Yildirim, Tim M Strom, Andreas Zimmer, Eckhard Wolf, Wolfgang Wurst, Thomas Klopstock, Johannes Beckers, Valerie Gailus-Durner, Martin Hrabé de Angelis
The vertebrate Scube (Signal peptide, CUB, and EGF-like domain-containing protein) family consists of three independent members, Scube1-3, which encode secreted cell surface-associated membrane glycoproteins. Limited information about the general function of this gene family is available, and their roles during adulthood. Here, we present the first Scube3 mutant mouse line (Scube3(N294K/N294K)), which clearly shows phenotypic alterations by carrying a missense mutation in exon 8, and thus contributes to our understanding of SCUBE3 functions...
December 7, 2016: G3: Genes—Genomes—Genetics
#9
Alexa Shull, Stefanie E Mayer, Ellen McGinnis, Elisa Geiss, Ivan Vargas, Nestor L Lopez-Duran
There is a growing realization that cognitive processes associated with stress coping, such as rumination and distraction, can impact the hypothalamic-pituitary-adrenal-axis (HPA-axis). Yet, little is known about what aspects of the HPA-axis stress response (rate of activation, duration of activation, rate of recovery) is impacted by such cognitive processes. This study examines the impact of both ruminative trait tendencies and experimentally induced rumination on salivary cortisol responses to a social evaluative stress task...
December 2016: Psychoneuroendocrinology
#10
Giuseppe Muscogiuri, Wolfgang G Rehwald, U Joseph Schoepf, Pal Suranyi, Sheldon E Litwin, Carlo N De Cecco, Julian L Wichmann, Stefanie Mangold, Damiano Caruso, Stephen R Fuller, Richard R Bayer 2nd, Akos Varga-Szemes
PURPOSE: To evaluate a new dark-blood late gadolinium enhancement (LGE) technique called "T(Rho) And Magnetization transfer and INvErsion Recovery" (TRAMINER) for the ability to detect myocardial LGE versus standard "bright-blood" inversion recovery (SIR) imaging. MATERIALS AND METHODS: This Institutional Review Board (IRB)-approved, Health Insurance Portability and Accountability Act (HIPAA)-compliant prospective study included 40 patients (62 ± 14 years [mean ± standard deviation (SD)], 29 males) with suspected myocardial infarction (MI) referred for the assessment of myocardial viability...
September 30, 2016: Journal of Magnetic Resonance Imaging: JMRI
#11
Stefanie Mangold, Julian L Wichmann, U Joseph Schoepf, Damiano Caruso, Christian Tesche, Daniel H Steinberg, Akos Varga-Szemes, Andrew C Stubenrauch, Richard R Bayer, Matthew Biancalana, Konstantin Nikolaou, Carlo N De Cecco
PURPOSE: To investigate diagnostic accuracy of 3(rd)-generation dual-source CT (DSCT) coronary angiography in obese and non-obese patients. METHODS: We retrospectively analyzed 76 patients who underwent coronary CT angiography (CCTA) and invasive coronary angiography. Prospectively ECG-triggered acquisition was performed with automated tube voltage selection (ATVS). Patients were dichotomized based on body mass index in groups A (<30 kg/m(2), n = 37) and B (≥30 kg/m(2), n = 39) and based on tube voltage in groups C (<120 kV, n = 46) and D (120 kV, n = 30)...
September 28, 2016: European Radiology
#12
Sibylle Sabrautzki, Michael A Sandholzer, Bettina Lorenz-Depiereux, Robert Brommage, Gerhard Przemeck, Ingrid L Vargas Panesso, Alexandra Vernaleken, Lillian Garrett, Katharina Baron, Ali O Yildirim, Jan Rozman, Birgit Rathkolb, Christine Gau, Wolfgang Hans, Sabine M Hoelter, Susan Marschall, Claudia Stoeger, Lore Becker, Helmut Fuchs, Valerie Gailus-Durner, Martin Klingenspor, Thomas Klopstock, Christoph Lengger, Leuchtenberger Stefanie, Eckhard Wolf, Tim M Strom, Wolfgang Wurst, Martin Hrabě de Angelis
Animal models resembling human mutations are valuable tools to research the features of complex human craniofacial syndromes. This is the first report on a viable dominant mouse model carrying a non-synonymous sequence variation within the endothelin receptor type A gene (Ednra c.386A>T, p.Tyr129Phe) derived by an ENU mutagenesis program. The identical amino acid substitution was reported recently as disease causing in three individuals with the mandibulofacial dysostosis with alopecia (MFDA, OMIM 616367) syndrome...
December 2016: Mammalian Genome: Official Journal of the International Mammalian Genome Society
#13
Damiano Caruso, Carlo N De Cecco, U Joseph Schoepf, Lloyd M Felmly, Akos Varga-Szemes, Stefanie Mangold, Christian Canstein, Thomas Allmendinger, Stephen R Fuller, Andrea Laghi, Julian L Wichmann
RATIONALE AND OBJECTIVES: Iterative reconstruction (IR) computed tomography (CT) techniques allow for radiation dose reduction while maintaining image quality. However, CT coronary artery calcium (CAC) scores may be influenced by certain IR algorithms. The aim of our study is to identify suitable correction factors to ensure consistency between IR and filtered back projection (FBP)-based CAC scoring. MATERIAL AND METHODS: A phantom study was performed to derive suitable correction factors for CAC scores and volume (VOL) values with advanced modeled iterative reconstruction (or ADMIRE) strength level 3 (ADM3) and 5 (ADM5) vs FBP...
September 7, 2016: Academic Radiology
#14
Lloyd M Felmly, Carlo N De Cecco, U Joseph Schoepf, Akos Varga-Szemes, Stefanie Mangold, Andrew D McQuiston, Sheldon E Litwin, Richard R Bayer, Thomas J Vogl, Julian L Wichmann
PURPOSE: To investigate feasibility, image quality and safety of low-tube-voltage, low-contrast-volume comprehensive cardiac and aortoiliac CT angiography (CTA) for planning transcatheter aortic valve replacement (TAVR). MATERIALS AND METHODS: Forty consecutive TAVR candidates prospectively underwent combined CTA of the aortic root and vascular access route (270 mgI/ml iodixanol). Patients were assigned to group A (second-generation dual-source CT [DSCT], 100 kV, 60 ml contrast, 4...
May 2017: European Radiology
#15
REVIEW
Christoph J Rageth, Elizabeth Am O'Flynn, Christopher Comstock, Claudia Kurtz, Rahel Kubik, Helmut Madjar, Domenico Lepori, Gert Kampmann, Alexander Mundinger, Astrid Baege, Thomas Decker, Stefanie Hosch, Christoph Tausch, Jean-François Delaloye, Elisabeth Morris, Zsuzsanna Varga
The purpose of this study is to obtain a consensus for the therapy of B3 lesions. The first International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions) including atypical ductal hyperplasia (ADH), flat epithelial atypia (FEA), classical lobular neoplasia (LN), papillary lesions (PL), benign phyllodes tumors (PT), and radial scars (RS) took place in January 2016 in Zurich, Switzerland organized by the International Breast Ultrasound School and the Swiss Minimally Invasive Breast Biopsy group-a subgroup of the Swiss Society of Senology...
September 2016: Breast Cancer Research and Treatment
#16
REVIEW
Damiano Caruso, Marwen Eid, U Joseph Schoepf, Kwang Nam Jin, Akos Varga-Szemes, Christian Tesche, Stefanie Mangold, Adam Spandorfer, Andrea Laghi, Carlo N De Cecco
Non-invasive cardiac imaging has rapidly evolved during the last decade due to advancements in CT based technologies. Coronary CT angiography has been shown to reliably assess coronary anatomy and detect high risk coronary artery disease. However, this technique is limited to anatomical assessment, thus non-invasive techniques for functional assessment of the heart are necessary. CT myocardial perfusion is a new CT based technique that provides functional assessment of the myocardium and allows for a comprehensive assessment of coronary artery disease with a single modality when combined with CTA...
October 2016: European Journal of Radiology
#17
Ivan Vargas, Stefanie Mayer, Nestor Lopez-Duran
The association between depression and the cortisol awakening response (CAR) has been widely examined, yet the results are mixed and factors responsible for such inconsistencies are poorly understood. The current study investigated whether the link between depressive symptomatology and CAR varied as a function of two such factors: sleep and gender. The sample included 58 young adults (30 females; Mage = 18.7; SDage = 0.91). Participants completed the Beck Depression Inventory as well as the Consensus Sleep Diary to assess depressive symptomatology and daily sleep patterns, respectively...
July 28, 2016: Stress and Health: Journal of the International Society for the Investigation of Stress
#18
COMPARATIVE STUDY
Julian L Wichmann, Andrew D Hardie, U Joseph Schoepf, Lloyd M Felmly, Jonathan D Perry, Akos Varga-Szemes, Stefanie Mangold, Damiano Caruso, Christian Canstein, Thomas J Vogl, Carlo N De Cecco
OBJECTIVES: To compare single-energy (SECT) and dual-energy (DECT) abdominal CT examinations in matched patient cohorts regarding differences in radiation dose and image quality performed with second- and third-generation dual-source CT (DSCT). METHODS: We retrospectively analysed 200 patients (100 male, 100 female; mean age 61.2 ± 13.5 years, mean body mass index 27.5 ± 3.8 kg/m(2)) equally divided into four groups matched by gender and body mass index, who had undergone portal venous phase abdominal CT with second-generation (group A, 120-kV-SECT; group B, 80/140-kV-DECT) and third-generation DSCT (group C, 100-kV-SECT; group D, 90/150-kV-DECT)...
February 2017: European Radiology
#19
COMPARATIVE STUDY
Stefanie Mangold, Carlo N De Cecco, Julian L Wichmann, Christian Canstein, Akos Varga-Szemes, Damiano Caruso, Stephen R Fuller, Fabian Bamberg, Konstantin Nikolaou, U Joseph Schoepf
PURPOSE: To compare, on an intra-individual basis, the effect of automated tube voltage selection (ATVS), integrated circuit detector and advanced iterative reconstruction on radiation dose and image quality of aortic CTA studies using 2nd and 3rd generation dual-source CT (DSCT). MATERIAL AND METHODS: We retrospectively evaluated 32 patients who had undergone CTA of the entire aorta with both 2nd generation DSCT at 120kV using filtered back projection (FBP) (protocol 1) and 3rd generation DSCT using ATVS, an integrated circuit detector and advanced iterative reconstruction (protocol 2)...
May 2016: European Journal of Radiology
#20
COMPARATIVE STUDY
Christian Tesche, Carlo N De Cecco, Damiano Caruso, Stefan Baumann, Matthias Renker, Stefanie Mangold, Kevin T Dyer, Akos Varga-Szemes, Moritz Baquet, David Jochheim, Ullrich Ebersberger, Richard R Bayer, Ellen Hoffmann, Daniel H Steinberg, U Joseph Schoepf
OBJECTIVE: Compare morphological and functional coronary plaque markers derived from coronary CT angiography (CCTA) for their ability to detect lesion-specific ischemia. MATERIALS AND METHODS: Data of patients who had undergone both dual-source CCTA and invasive fractional flow reserve (FFR) measurement within 3 months were retrospectively analyzed. Various quantitative stenosis markers were derived from CCTA: Corrected coronary opacification (CCO), transluminal attenuation gradient (TAG), remodeling index (RI), computational FFR (cFFR), lesion length (LL), vessel volume (VV), total plaque volume (TPV), and calcified and non-calcified plaque volume (CPV and NCPV)...
May 2016: Journal of Cardiovascular Computed Tomography
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