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https://www.readbyqxmd.com/read/29788294/epigallocatechin-3-gallate-protected-vanadium-induced-eggshell-depigmentation-via-p38mapk-nrf2-ho-1-signaling-pathway-in-laying-hens
#1
J Wang, Z Yuan, K Zhang, X Ding, S Bai, Q Zeng, H Peng, P Celi
It has been demonstrated that tea polyphenol (TP) epigallocatechin-3-gallate (EGCG) can confer protection against vanadium (V) toxicity in laying hens; however, our understanding of the molecular mechanisms beyond this effect are still limited. In this study, 360 hens were randomly assigned to the 3 groups to study whether the potential mechanism P38MAPK-Nrf2/HO-1 signaling pathway is involved in the protective effect of EGCG on eggshell pigmentation in vanadium challenged laying hens. Treatments included a control group, a 10 mg/kg V (V10), and a V10 plus 130 mg/kg of EGCG group (V10+EGCG130)...
May 19, 2018: Poultry Science
https://www.readbyqxmd.com/read/29787277/targeting-of-egfr-vegfr2-and-akt-by-engineered-dual-drug-encapsulated-mesoporous-silica-gold-nanoclusters-sensitizes-tamoxifen-resistant-breast-cancer
#2
Bn Prashanth Kumar, Nagaprasad Puvvada, Shashi Rajput, Siddik Sarkar, Madhusudan Kr Mahto, Murali M Yallapu, Amita Pathak, Luni Emdad, Swadesh K Das, Rui L Reis, Subhas C Kundu, Paul B Fisher, Mahitosh Mandal
Tamoxifen has improved overall disease-free survival and reduced mortality rates in cancer patients. However, breast cancer patients often fail to respond to tamoxifen therapy due to the development of a drug-resistant phenotype. Functional analysis and molecular studies suggest that protein mutation and dysregulation of survival signaling molecules such as epidermal growth factor receptor, vascular endothelial growth factor receptor 2 and Akt contribute to tamoxifen resistance. Various strategies, including combinatorial therapies, show to chemo-sensitize tamoxifen-resistant cancers...
May 22, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29786471/the-effects-of-polyphenol-supplementation-on-adipose-tissue-morphology-and-gene-expression-in-overweight-and-obese-humans
#3
Jasper Most, Ines Warnke, Mark V Boekschoten, Johan W E Jocken, Philip de Groot, Angelika Friedel, Igor Bendik, Gijs H Goossens, Ellen E Blaak
Dietary polyphenols have beneficial effects on adipose tissue mass and function in rodents, but human studies are scarce. In a randomized, placebo-controlled study, 25 (10 women) overweight and obese humans received a combination of the polyphenols epigallocatechin-gallate and resveratrol (282 mg/d, 80 mg/d, respectively, EGCG+RES, n = 11) or placebo (PLA, n = 14) supplementation for 12 weeks. Abdominal subcutaneous adipose tissue (SAT) biopsies were collected for assessment of adipocyte morphology and micro-array analysis...
May 1, 2018: Adipocyte
https://www.readbyqxmd.com/read/29781252/subtype-selective-inhibition-of-acid-sensing-ion-channel-3-by-a-natural-flavonoid
#4
Xiao-Gang Yan, Wei-Guang Li, Xin Qi, Jia-Jie Zhu, Chen Huang, Shao-Ling Han, Qin Jiang, Tian-Le Xu, Jian-Hua Liu
AIMS: Acid-sensing ion channels (ASICs) are extracellular proton-gated cation channels that have been implicated in multiple physiological and pathological processes, and peripheral ASIC3 prominently participate into the pathogenesis of chronic pain, itch, and neuroinflammation, which necessitates the need for discovery and development of novel modulators in a subtype-specific manner. METHODS: Whole-cell patch clamp recordings and behavioral assays were used to examine the effect of several natural compounds on the ASIC-mediated currents and acid-induced nocifensive behavior, respectively...
May 20, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29777127/paradoxical-cardiotoxicity-of-intraperitoneally-injected-epigallocatechin-gallate-preparation-in-diabetic-mice
#5
Nora O Abdel Rasheed, Lamiaa A Ahmed, Dalaal M Abdallah, Bahia M El-Sayeh
Numerous clinical and bioavailability studies addressed epigallocatechin gallate (EGCG) beneficial effects; however, our previous work revealed EGCG-induced nephrotoxicity in the presence of diabetes. In this study, the potential myocardial toxicity of EGCG preparation (100 mg/kg/day, IP; 4 days) in diabetic mice injected with streptozotocin (STZ; 150 mg/kg, IP) was investigated. Diabetic mice receiving EGCG preparation showed electrocardiographic changes in addition to elevation of both serum creatine kinase-MB and troponin-I levels accompanied by microscopic myocardial damage...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29772299/biophenols-enzymes-%C3%AE-secretase-cholinesterases-histone-deacetylase-and-tyrosinase-inhibitors-from-olive-olea-europaea-l
#6
Syed Haris Omar, Christopher J Scott, Adam S Hamlin, Hassan K Obied
The focus of this study was on inhibition of enzymes involved in the pathogenesis Alzheimer's disease (AD) including prime amyloid beta (Aβ) producing enzyme (β-secretase: BACE-1) and disease progression enzymes including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), histone deacetylase (HDAC), and tyrosinase along with the catecholamine L-DOPA, by using olive biophenols. Here we report the strongest inhibition of BACE-1 from rutin (IC50 : 3.8 nM) followed by verbascoside (IC50 : 6.3 nM) and olive fruit extract (IC50 : 18 ng), respectively...
May 14, 2018: Fitoterapia
https://www.readbyqxmd.com/read/29770336/epigallocatechin-3-gallate-reduces-neuronal-apoptosis-in-rats-after-middle-cerebral-artery-occlusion-injury-via-pi3k-akt-enos-signaling-pathway
#7
Wang Nan, Xu Zhonghang, Chen Keyan, Liu Tongtong, Guo Wanshu, Xu Zhongxin
Background/Aims: Epigallocatechin-3-gallate (EGCG) has neuroprotective effects and the ability to resist amyloidosis. This study observed the protective effect of EGCG against neuronal injury in rat models of middle cerebral artery occlusion (MCAO) and investigated the mechanism of action of PI3K/AKT/eNOS signaling pathway. Methods: Rat models of permanent MCAO were established using the suture method. Rat behavior was measured using neurological deficit score. Pathology and apoptosis were measured using HE staining and TUNEL...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29767332/recent-development-in-antihyperalgesic-effect-of-phytochemicals-anti-inflammatory-and-neuro-modulatory-actions
#8
REVIEW
Ajeet Kumar Singh, Sanjay Kumar, Manjula Vinayak
INTRODUCTION: Pain is an unpleasant sensation triggered by noxious stimulation. It is one of the most prevalent conditions, limiting productivity and diminishing quality of life. Non steroidal anti inflammatory drugs (NSAIDs) are widely used as pain relievers in present day practice as pain is mostly initiated due to inflammation. However, due to potentially serious side effects, long term use of these antihyperalgesic drugs raises concern. Therefore there is a demand to search novel medicines with least side effects...
May 16, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29762899/metagenomics-analysis-of-gut-microbiota-in-a-high-fat-diet-induced-obesity-mouse-model-fed-with-epigallocatechin-3-o-3-o-methyl-gallate-egcg3-me
#9
Xin Zhang, Yuhui Chen, Jieyu Zhu, Man Zhang, Chi-Tang Ho, Qingrong Huang, Jinxuan Cao
SCOPE: (-)-Epigallocatechin 3-O-(3-O-methyl) gallate (EGCG3''Me) has been shown to have a modulatory effect on human intestinal microbiota, and the relationship between intestinal flora and obesity has attracted more and more attention recently. Here, we investigated the potential link between EGCG3''Me and gut microbiota composition, as well as the underlying mechanisms of the anti-obesity activity of EGCG3''Me. METHODS AND RESULTS: EGCG3''Me was prepared from oolong tea by column chromatography, and the influence of EGCG3''Me on intestinal microbiota was analysed using a human flora-associated high fat diet (HFD)-induced obesity mouse model by metagenomics...
May 15, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29762529/combined-analysis-of-the-fruit-metabolome-and-transcriptome-reveals-candidate-genes-involved-in-flavonoid-biosynthesis-in-actinidia-arguta
#10
Yukuo Li, Jinbao Fang, Xiujuan Qi, Miaomiao Lin, Yunpeng Zhong, Leiming Sun, Wen Cui
To assess the interrelation between the change of metabolites and the change of fruit color, we performed a combined metabolome and transcriptome analysis of the flesh in two different Actinidia arguta cultivars: "HB" ("Hongbaoshixing") and "YF" ("Yongfengyihao") at two different fruit developmental stages: 70d (days after full bloom) and 100d (days after full bloom). Metabolite and transcript profiling was obtained by ultra-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometer and high-throughput RNA sequencing, respectively...
May 15, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29762498/cytoprotective-effect-of-epigallocatechin-gallate-egcg-5-o-%C3%AE-glucopyranoside-a-novel-egcg-derivative
#11
Sang Yun Han, Eunji Kim, Kyeonghwan Hwang, Zubair Ahmed Ratan, Hyunsik Hwang, Eun-Mi Kim, Doman Kim, Junseong Park, Jae Youl Cho
Epigallocatechin gallate (EGCG) is a well-studied polyphenol with antioxidant effects. Since EGCG has low solubility and stability, many researchers have modified EGCG residues to ameliorate these problems. A novel EGCG derivative, EGCG-5'- O -α-glucopyranoside (EGCG-5'Glu), was synthesized, and its characteristics were investigated. EGCG-5'Glu showed antioxidant effects in cell and cell-free systems. Under SNP-derived radical exposure, EGCG-5'Glu decreased nitric oxide (NO) production, and recovered ROS-mediated cell viability...
May 15, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29759183/evaluation-of-thrombin-inhibitory-activity-of-catechins-by-online-capillary-electrophoresis-based-immobilized-enzyme-microreactor-and-molecular-docking
#12
Qiao-Qiao Li, Feng-Qing Yang, Yin-Zhen Wang, Zhao-Yu Wu, Zhi-Ning Xia, Hua Chen
An online capillary electrophoresis (CE)-based thrombin (THR) immobilized enzyme microreactor (IMER) method was established to screen THR inhibitors in this study. S-2366 was used as chromogenic substrate for determination of THR activity and other kinetic constants. After continuously run for 50 times, the prepared IMER could still remain 89% of the initial immobilized enzyme activity. The Michaelis-Menten constant (Km ) of immobilized THR was measured as 0.514 mmol/L and the half-maximal inhibitory concentration (IC50 ) and inhibition constant (Ki ) of argatroban on THR were determined as 78...
August 1, 2018: Talanta
https://www.readbyqxmd.com/read/29751678/-epigallocatechin-3-gallate-synthetic-analogues-inhibit-fatty-acid-synthase-and-show-anticancer-activity-in-triple-negative-breast-cancer
#13
Joan Crous-Masó, Sònia Palomeras, Joana Relat, Cristina Camó, Úrsula Martínez-Garza, Marta Planas, Lidia Feliu, Teresa Puig
(-)-Epigallocatechin 3-gallate (EGCG) is a natural polyphenol from green tea with reported anticancer activity and capacity to inhibit the lipogenic enzyme fatty acid synthase (FASN), which is overexpressed in several human carcinomas. To improve the pharmacological profile of EGCG, we previously developed a family of EGCG derivatives and the lead compounds G28, G37 and G56 were characterized in HER2-positive breast cancer cells overexpressing FASN. Here, diesters G28, G37 and G56 and two G28 derivatives, monoesters M1 and M2, were synthesized and assessed in vitro for their cytotoxic, FASN inhibition and apoptotic activities in MDA-MB-231 triple-negative breast cancer (TNBC) cells...
May 11, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29747413/binding-of-catechins-to-staphylococcal-enterotoxin-a
#14
Yuko Shimamura, Mio Utsumi, Chikako Hirai, Shogo Nakano, Sohei Ito, Ai Tsuji, Takeshi Ishii, Takahiro Hosoya, Toshiyuki Kan, Norio Ohashi, Shuichi Masuda
Staphylococcal enterotoxin A (SEA) is a toxin protein, and is the most common cause of staphylococcal food poisoning. Polyphenols, such as catechins, are known to interact with proteins. In this study, we investigated the binding of catechins to SEA using SPR (Biacore), Fourier transform infrared spectroscopy (FT-IR), isothermal titration calorimetry (ITC), and protein-ligand docking. We found that (−)-epigallocatechin gallate (EGCG) could strongly bind to SEA. According to thermodynamic parameters, a negative Δ G indicated that the interaction between EGCG and SEA was spontaneous, and the electrostatic force accompanied by hydrophobic binding forces may play a major role in the binding...
May 9, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29745376/corrigendum-epigallocatechin-3-gallate-ameliorates-atherosclerosis-and-modulates-hepatic-lipid-metabolic-gene-expression-in-apolipoprotein-e-knockout-mice-involvement-of-ttc39b
#15
Wei Wang, Zheng-Zhu Zhang, Yan Wu, Ru-Qing Wang, Jin-Wu Chen, Jing Chen, Yan Zhang, Ya-Jun Chen, Ming Geng, Zhong-Dong Xu, Min Dai, Jin-Hua Li, Li-Long Pan
[This corrects the article on p. 195 in vol. 9, PMID: 29593532.].
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29744906/on-line-high-performance-liquid-chromatography-coupled-with-biochemical-detection-method-for-screening-of-%C3%AE-glucosidase-inhibitors-in-green-tea
#16
Peng-Cheng Guo, Hua-Dan Shen, Jiang-Ji Fang, Tian-Ming Ding, Xiao-Ping Ding, Jun-Feng Liu
An on-line high performance liquid chromatography- biochemical detection (HPLC-BCD) method, which compounds separated by HPLC were on-line reacted with enzyme and substrate solutions delivered by flow injection and enzyme inhibition signal was collected in time by UV detector, was developed to rapidly screen α-glucosidase inhibitors from green tea extracts in this study. The chromatographic fingerprints and enzyme inhibition profiles of the different brands of green tea could be simultaneously detected by the on-line HPLC-BCD method...
May 9, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29744892/-epigallocatechin-3-gallate-induces-grp78-accumulation-in-the-er-and-shifts-mesothelioma-constitutive-upr-into-proapoptotic-er-stress
#17
Simona Martinotti, Elia Ranzato, Bruno Burlando
GRP78 is a molecular chaperone of the endoplasmic reticulum (ER) that aids proper folding of nascent polypeptides. When unfolded proteins accumulate, GRP78 triggers unfolded protein response (UPR), involving activation of transcription factors like XBP1 and CHOP that may restore cell homeostasis. Increased expression of GRP78 and mild UPR can be constitutive in cancer cells, hindering apoptosis, and promoting cell survival, for example, by GRP78 relocation to the plasma membrane that activates MAPK and PI3 K/AKT pathways...
May 10, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29742465/myricetin-induced-apoptosis-of-triple-negative-breast-cancer-cells-is-mediated-by-the-iron-dependent-generation-of-reactive-oxygen-species-from-hydrogen-peroxide
#18
Allison Knickle, Wasundara Fernando, Anna L Greenshields, H P Vasantha Rupasinghe, David W Hoskin
Myricetin is a dietary phytochemical with anticancer activity; however, the effect of myricetin on breast cancer cells remains unclear. Here, we show that myricetin inhibited the growth of triple-negative breast cancer (TNBC) cells but was less inhibitory for normal cells. The effect of myricetin was comparable to epigallocatechin gallate and doxorubicin, and greater than resveratrol and cisplatin. Myricetin-treated TNBC cells showed evidence of early and late apoptosis/necrosis, which was associated with intracellular reactive oxygen species (ROS) accumulation, extracellular regulated kinase 1/2 and p38 mitogen-activated protein kinase activation, mitochondrial membrane destabilization and cytochrome c release, and double-strand DNA breaks...
May 6, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29740891/effects-of-gut-microbiota-and-time-of-treatment-on-tissue-levels-of-green-tea-polyphenols-in-mice
#19
Anna B Liu, Siyao Tao, Mao-Jung Lee, Qi Hu, Xiaofeng Meng, Yong Lin, Chung S Yang
The previous studies have shown that tea polyphenols are metabolized by gut microbiota. This study investigated the effect of gut microbiota on the bioavailability, tissue levels, and degradation of tea polyphenols. Mice were treated with antibiotics (ampicillin/sulfamethoxazole/trimethoprim) in drinking water and the control mice received water for 11 days, and they were given an AIN93M diet enriched with 0.32% of Polyphenon E. The levels of catechins and their metabolites (if present) in the serum, liver, urine, and fecal samples were determined by high-performance liquid chromatography...
May 8, 2018: BioFactors
https://www.readbyqxmd.com/read/29739590/quantification-of-ascorbyl-adducts-of-epigallocatechin-gallate-and-gallocatechin-gallate-in-bottled-tea-beverages
#20
Wei-Lun Hung, Siyu Wang, Shengmin Sang, Xiaochun Wan, Yu Wang, Chi-Tang Ho
Catechins are the major bioactive compounds existing in tea leaves (Camellia sinensis). Dehydroascorbic acid is (DHAA) a reactive dicarbonyl species and previous studies have demonstrated that catechins could effectively trap DHAA to form ascorbyl adducts of catechins, especially epigallocatechin gallate (EGCG). Since catechins in the aqueous solution are unstable due to their structural features, ascorbic acid (AA) is usually added to bottled tea beverages to protect catechins. However, whether ascorbyl adducts of catechins are formed in bottled tea beverages remains unclear...
September 30, 2018: Food Chemistry
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