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Epigallocatechin

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https://www.readbyqxmd.com/read/29146347/effect-of-tea-products-on-the-in-vitro-enzymatic-digestibility-of-starch
#1
Haihua Zhang, Yulan Jiang, Junxian Pan, Yangjun Lv, Jun Liu, Shikang Zhang, Yuejin Zhu
The importance of postprandial hyperglycemia in the treatment of diabetes has been recognized recently. Tea products, such as tea polyphenols (TP), epigallocatechin gallate (EGCG), matcha, and instant tea, were chosen as constituents of tea-flour food, aimed at regulating the release of glucose from starchy foods in the postprandial period. Six starches were chosen for internal composition analysis and hydrolysis studies in vitro. Corn starch, wheat starch, and lily root flour appeared to have higher resistant starch content, slower digestion profiles, and lower kinetic constants, implying sustained release of glucose in the gastrointestinal tract...
March 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29137307/reversal-of-5-fluorouracil-resistance-by-egcg-is-mediate-by-inactivation-of-tfap2a-vegf-signaling-pathway-and-down-regulation-of-mdr-1-and-p-gp-expression-in-gastric-cancer
#2
Hongsheng Tang, Lisi Zeng, Jiahong Wang, Xiangliang Zhang, Qiang Ruan, Jin Wang, Shuzhong Cui, Dinghua Yang
The effect of 5-fluorouracil (5-FU) chemotherapy for gastric cancer (GC) is limited by drug-resistance. To conquer this drug-resistance, various treatments including combination therapy have been used, but the overall survival has not been improved yet. In our current study, 5-FU resistant GC cells, SGC7901/FU and MGC803/FU, were established by long term exposure to 5-FU, and the proliferation capability of these resistant cells was verified to be reduced. The drug related proteins, MDR1 and P-gp were up-regulated in resistant cells compared to the parental cells...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29136554/separation-and-purification-of-four-phenolic-compounds-from-persimmon-by-high-speed-counter-current-chromatography
#3
Jinming Peng, Kaikai Li, Wei Zhu, Xiangyi Deng, Chunmei Li
An efficient method was established by high-speed counter-current chromatography (HSCCC) for preparation of four phenolic compounds from the depolymerization products of persimmon tannin. Using the two solvent systems of n-hexane/ethyl acetate/water (3:17:20, v/v/v) and ethyl acetate/methanol/water (50:1:50, v/v/v), the preparative isolation was successfully performed by a two-step separation. The yields of one run (150mg crude sample) for gallic acid, methyl gallate, and epigallocatechin-3-gallate-(4β→8, 2β→O→7)-epigallocatechin-3-gallate dimer (A-type EGCG dimer) were 4...
November 7, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29131612/functional-characterization-of-epitheaflagallin-3-o-gallate-generated-in-laccase-treated-green-tea-extracts-in-the-presence-of-gallic-acid
#4
Nobuya Itoh, Junji Kurokawa, Yasuhiro Isogai, Masaru Ogasawara, Takayuki Matsunaga, Tutomu Okubo, Yuji Katsube
Epitheaflagallin (ETFG) and epitheaflagallin 3-O-gallate (ETFGg) are minor polyphenols in black tea extract that are enzymatically synthesized from epigallocatechin (EGC) and epigallocatechin gallate (EGCg), respectively, in green tea extract via laccase oxidation in the presence of gallic acid. The constituents of laccase-treated green tea extract in the presence of gallic acid are thus quite different from those of non-laccase-treated green tea extract: EGC and EGCg are present in lower concentrations, and ETFG and ETFGg are present in higher concentrations...
November 13, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29129901/the-inhibitory-effects-of-anthocyanin-rich-sunrouge-tea-on-pancreatic-lipase-activity
#5
Nobuya Shirai
This study investigated the in vitro and in vivo effects of Sunrouge (SR), which is an anthocyaninrich green tea. Hot and cold water extracts (CWEX) of Yabukita (YK; regular green tea), SR second crop (SR2), and SR third crop (SR3) were prepared. The 50% inhibitory concentrations for YK, SR2, and SR3 CWEXs against pancreatic lipase in vitro were 12.3±2.8, 6.2±0.3, and 4.0±1.1 mg/mL, respectively. Epigallocatechin gallate (EGCG) accounted for 4.3%, 6.0%, and 6.3% of YK, SR2, and SR3 CWEXs, respectively. SR2 had the highest anthocyanin content of these three samples...
November 13, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/29127880/effects-of-flavonoids-on-microrna-145-regulation-through-klf4-and-myocardin-in-neointimal-formation-in-vitro-and-in-vivo
#6
Chiu-Mei Lin, Bao-Wei Wang, Chun-Ming Pan, Wei-Jen Fang, Su-Kiat Chua, Sheng-Wen Hou, Hang Chang, Kou-Gi Shyu
MicroRNA 145 (miR-145) is a critical modulator of vascular smooth muscle cell (VSMC) phenotyping and proliferation. Flavonoids have been studied extensively due to their diverse pharmacological properties, including anti-inflammatory effects. The aims of this study is designed to evaluate the atheroprotective effects on angiotensin II (Ang II)-induced miR-145 and Klf4/myocardin expression in vitro and in vivo of flavonoids, including (-)-epigallocatechin gallate (EGCG), chrysin, wogonin, silibinin, and ferulic acid...
September 14, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29122665/in-vitro-screening-of-dual-flavonoid-combinations-for-reversing-p-glycoprotein-mediated-multidrug-resistance-focus-on-antiepileptic-drugs
#7
Ana Ferreira, Adriana O Santos, Amílcar Falcão, Gilberto Alves
The combined use of different P-glycoprotein (P-gp) inhibitors may be a relevant approach to the synergistic and safer inhibition of the P-gp-mediated drug efflux. Herein, we aimed to explore dual combinations of the flavonoids baicalein, (-)-epigallocatechin gallate, kaempferol, quercetin and silymarin to reverse the interference of P-gp on the intracellular accumulation of antiepileptic drugs (AEDs). The intracellular accumulation of rhodamine 123 (a classic P-gp substrate) and of several commonly used AEDs (carbamazepine, phenytoin, oxcarbazepine) or their metabolites (carbamazepine-10,11-epoxide and licarbazepine) was evaluated in MDCK-MDR1 cells in the presence and absence of individual flavonoids and their combinations...
November 6, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29120370/amorphous-solid-dispersion-of-epigallocatechin-gallate-for-enhanced-physical-stability-and-controlled-release
#8
Yizheng Cao, Jing Teng, Jon Selbo
Epigallocatechin gallate (EGCG) has been recognized as the most prominent green tea extract due to its healthy influences. The high instability and low bioavailability, however, strongly limit its utilization in food and drug industries. This work, for the first time, develops amorphous solid dispersion of EGCG to enhance its bioavailability and physical stability. Four commonly used polymeric excipients are found to be compatible with EGCG in water-dioxane mixtures via a stepwise mixing method aided by vigorous mechanical interference...
November 9, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/29119790/green-tea-polyphenols-decrease-strecker-aldehydes-and-bind-to-proteins-in-lactose-hydrolyzed-uht-milk
#9
Therese Jansson, Valentin Rauh, Bente P Danielsen, Mahesha M Poojary, Sandra S Waehrens, Wender L P Bredie, John Sørensen, Mikael A Petersen, Colin A Ray, Marianne N Lund
The effect of epigallocatechin gallate enriched green tea extract (GTE) on flavor, Maillard reactions and protein modifications in lactose-hydrolyzed (LH) ultrahigh temperature (UHT) processed milk was examined during storage at 40 °C for up to 42 days. Addition of GTE inhibited the formation of Strecker aldehydes by up to 95% compared to control milk, and the effect was similar when GTE was added either before or after UHT treatment. Release of free amino acids, caused by proteolysis, during storage was also decreased in GTE-added milk either before or after UHT treatment compared to control milk...
November 17, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29117537/antioxidant-effects-of-epigallocatechin-3-gallate-on-the-atc1-6-pancreatic-alpha-cell-line
#10
Ting Cao, Xiong Zhang, Dan Yang, Yue-Qian Wang, Zheng-Dong Qiao, Jian-Ming Huang, Peng Zhang
Hypoglycemia is a major barrier to achieving stable metabolic control in patients with diabetes which is a serious clinical concern. With progression of diabetes, the ability of pancreatic α-cells which respond to hypoglycemia becomes impaired; However, it is not clear whether the dysfunctional responses of α-cells during hypoglycemia are related with oxidative stress. In the present study, we investigated whether epigallocatechin-3-gallate (EGCG) has antioxidant potential on pancreatic alpha TC1-6 (αTC1-6) cell lines and protect the normal function of α-cells from H2O2 induced oxidative stress...
November 5, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29115797/polyphenol-epigallocatechin-3-gallate-inhibits-hypoxia-reoxygenation-induced-h9c2-cell-apoptosis
#11
Wenlong Wang, Xiaohui Huang, Deliang Shen, Zonghua Ming, Mei Zheng, Jinying Zhang
BACKGROUND: We aimed to observe the protective effect of EGCG on hypoxia/reoxygenation injury of H9C2 myocardial cells and to study the inhibition mechanism of EGCG on hypoxia/reoxygenation injury of H9C2 myocardial cells. METHODS: H9C2 cells were used as the objects of study and hypoxia/reoxygenation cells were pretreated with EGCG in different concentrations. MTT, Hoechst 33258 and LDH were used to detect the viability and apoptosis of H9C2 cells. The protection mechanism of polyphenol epigallocatechin-3-gallate was studied via western blotting and mitochondrial membrane potential detection...
November 7, 2017: Minerva Medica
https://www.readbyqxmd.com/read/29113871/oxidative-stress-and-dietary-phytochemicals-role-in-cancer-chemoprevention-and-treatment
#12
Shireen Chikara, Lokesh Dalasanur Nagaprashantha, Jyotsana Singhal, David Horne, Sanjay Awasthi, Sharad S Singhal
Several epidemiological observations have shown an inverse relation between consumption of plant-based foods, rich in phytochemicals, and incidence of cancer. Phytochemicals, secondary plant metabolites, via their antioxidant property play a key role in cancer chemoprevention by suppressing oxidative stress-induced DNA damage. In addition, they modulate several oxidative stress-mediated signaling pathways through their anti-oxidant effects, and ultimately protect cells from undergoing molecular changes that trigger carcinogenesis...
November 4, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29113283/epigallocatechin-3-gallate-induces-apoptosis-in-acute-promyelocytic-leukemia-cells-via-a-shp-1-p38%C3%AE-mapk-bax-cascade
#13
Liugen Gan, Liang Zhong, Zhiling Shan, Chunlan Xiao, Ting Xu, Hao Song, Liu Li, Rong Yang, Beizhong Liu
Acute promyelocytic leukemia (APL) is characterized by a specific chromosomal translation, resulting in a fusion gene that affects the differentiation, proliferation and apoptosis of APL cells. Epigallocatechin-3-gallate (EGCG), a catechin, exhibits numerous biological functions, including antitumor activities. Previous studies have reported that EGCG induces apoptosis in NB4 cells. However, the molecular mechanism underlying EGCG-induced apoptosis remains unclear. The present study aimed to determine the molecular basis of EGCG-induced apoptosis in NB4 cells...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29111045/physical-properties-and-antioxidant-capacity-of-chitosan-epigallocatechin-3-gallate-films-reinforced-with-nano-bacterial-cellulose
#14
Xuejiao Wang, Yumei Xie, Hanjing Ge, Lin Chen, Jiali Wang, Shuang Zhang, Yan Guo, Zhixi Li, Xianchao Feng
Films with antioxidant activity were prepared by combining chitosan (CH) and epigallocatechin-3-gallate (EGCG) with nano-bacterial cellulose (BC) as a reinforcement agent. Results showed that BC addition improved the qualities of films jeopardized by EGCG. Fourier Transform Infrared (FTIR) spectroscopy analysis confirmed that there were intermolecular interactions among BC, CH and EGCG though hydrogen bonding. Consequently, BC addition increased the crystallinity and thermal stability of CH-BC5/10-EGCG15/30 films analyzed by X-ray diffraction (XRD) and thermogravimetric (TGA) analysis...
January 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29107927/photochemoprotective-effect-of-a-fraction-of-a-partially-purified-extract-of-byrsonima-crassifolia-leaves-against-uvb-induced-oxidative-stress-in-fibroblasts-and-hairless-mice
#15
Rebeca Oliveira de Souza, Geórgia de Assis Dias Alves, Ana Luiza Scarano Aguillera, Hervé Rogez, Maria José Vieira Fonseca
Ultraviolet B (UVB) irradiation increases the risk of various skin disorders, leading to inflammation and oxidative stress and thereby increasing the risk of skin photoaging and carcinogenesis. The use of photochemoprotectors such as natural products with antioxidant and anti-inflammatory properties represents a strategy for preventing UVB-induced skin damage. We investigated the photochemoprotective effect of a fraction of a partially purified extract of Byrsonima crassifolia leaves (BCF) on fibroblasts and hairless mice exposed to UVB radiation...
October 28, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29107025/association-of-changes-in-er-stress-mediated-signaling-pathway-with-lead-induced-insulin-resistance-and-apoptosis-in-rats-and-their-prevention-by-a-type-dimeric-epigallocatechin-3-gallate
#16
Chan-Min Liu, Jie-Qiong Ma, Jian-Mei Sun, Zhao-Jun Feng, Chao Cheng, Wei Yang, Hong Jiang
A-type dimeric epigallocatechin-3-gallate (A-type-EGCG-dimer, AEd), a new proanthocyanidins dimer from persimmon fruits, has been shown to have health benefit effects. However, A-type-EGCG-dimer affects gluose metabolism in the liver and the underlying mechanism is not clarified. The present study aims to examine the protective effects of A-type-EGCG-dimer on Pb-induced hepatic insulin resistance, endoplasmic reticulum (ER) stress and apoptosis in rats. Male wistar rats exposed to 0.05% w/v Pb acetate in the drinking water with or without A-type-EGCG-dimer coadministration (200 mg/kg body weight/day, intragastrically) for three months...
October 27, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29103764/additive-cytotoxic-effects-of-radiation-and-mtor-inhibitors-in-a-cervical-cancer-cell-line
#17
Daniele Xavier Assad, Gabriel Alvares Borges, Samuel Ramalho Avelino, Eliete Neves Silva Guerra
The PI3K/AKT/mTOR signaling pathway is frequently activated in HPV-positive cervical squamous cell cancer (CC). This study investigated the biological effects of mTOR inhibitors associated with radiotherapy in a CC cell line (HeLa). A human keratinocyte cell line (HaCaT) was used as control. Temsirolimus, everolimus, resveratrol, curcumin and epigallocatechin gallate (EGCG) were the mTOR inhibitors assessed. The 50% cell cytotoxicity rate (CC50) for each treatment was determined by MTT cell viability assay...
November 2, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29096961/cooking-and-co-ingested-polyphenols-reduce-in-vitro-methylmercury-bioaccessibility-from-fish-and-may-alter-exposure-in-humans
#18
Catherine Girard, Tania Charette, Maxime Leclerc, B Jesse Shapiro, Marc Amyot
Fish consumption is a major pathway for mercury exposure in humans. Current guidelines and risk assessments assume that 100% of methylmercury (MeHg) in fish is absorbed by the human body after ingestion. However, a growing body of literature suggests that this absorption rate may be overestimated. We used an in vitro digestion method to measure MeHg bioaccessibility in commercially-purchased fish, and investigated the effects of dietary practices on MeHg bioaccessibility. Cooking had the greatest effect, decreasing bioaccessibility on average to 12...
October 30, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29093332/anti-obesity-effect-of-halophyte-crop-limonium-tetragonum-in-high-fat-diet-induced-obese-mice-and-3t3-l1-adipocytes
#19
Na-Hyun Kim, Jeong-Doo Heo, Jung-Rae Rho, Min Hye Yang, Eun Ju Jeong
Halophyte Limonium tetragonum has recently been of interest in Korea for its nutritional value and salty taste which made it an ideal vegetable. In this study, the potential of L. tetragonum preventing excess weight gain, obesity and the related health problem has been evaluated in vitro and in vivo. The treatment with 100 mg/kg of L. tetragonum EtOAc soluble fraction (EALT) apparently prevented the body weight gain, adipose tissue weight gain, and the increase of triglyceride and total cholesterol level in mice fed a high-fat diet for 8 weeks...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29091862/the-anti-hyperuricemic-effect-of-epigallocatechin-3-gallate-egcg-on-hyperuricemic-mice
#20
Chuang Zhu, Yan Xu, Zeng-Hui Liu, Xiao-Chun Wan, Da-Xiang Li, Ling-Ling Tai
Epigallocatechin-3-gallate (EGCG), a major constituent of green tea catechin, has been used for antioxidant. This study aimed to evaluate the antihyperuricemic activity of EGCG on hyperuricemic mice. We demonstrated that serum uric acid (UA) level was decreased significantly with dose-dependence by EGCG treated with 10, 20, and 50mg/kg. Compared with the model, data on blood urea nitrogen (BUN) supported that there was significance with high dose of EGCG (50mg/kg). Levels of serum creatinine (Cr) in each EGCG-treated group were decreased but not significant; the activities of hepatic xanthine oxidase (XOD) and adenosine deaminase (ADA) in high dose groups' EGCG were notably lower than those of model group...
October 26, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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