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Craniofacial orthopedics

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https://www.readbyqxmd.com/read/29186392/hawthorne-effect-reporting-in-orthodontic-randomized-controlled-trials-truth-or-myth-blessing-or-curse
#1
Salem Abdulraheem, Lars Bondemark
Objective: To investigate in 10 orthodontic journals how many randomized controlled trials (RCTs) considered the Hawthorne effect, and if considered, to determine whether it was related to the patients or the therapists involved in the trial and, finally, to discuss the Hawthorne effect in an educational way. Materials and methods: A search was performed on the Medline database, via PubMed, for publication type 'randomized controlled trial' published for each journal between 1 August 2007 and 31 July 2017...
November 28, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/29069355/intention-to-treat-itt-analysis-as-reported-in-orthodontic-randomized-controlled-trials-evaluations-of-methodology-and-recommendations-for-the-accurate-use-of-itt-analysis-and-handling-dropouts
#2
Lars Bondemark, Salem Abdulraheem
Objective: To systematically evaluate in five orthodontic journals how many randomized controlled trials (RCTs) use intention to treat (ITT) analysis and to assess the methodological quality of the ITT analysis, and finally, to demonstrate in an academic way how outcomes can be affected when not implementing the ITT analysis. Material and methods: A search of the database, Medline, was performed via PubMed for publication type 'randomized controlled trial' published for each journal between 1 January 2013 and 30 April 2017...
October 21, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/29042703/modification-of-dentofacial-growth-associated-with-goldenhar-syndrome
#3
Ei Ei Hsu Hlaing, Yoshihito Ishihara, Chikako Hara, Hiroshi Kamioka
The rare developmental defect, Goldenhar syndrome is characterized by complex craniofacial and dentofacial anomalies. Here we describe the successful orthodontic treatment of a 5-year-old Japanese Goldenhar syndrome patient with mild facial asymmetry, right microtia, right-side hearing loss, and tongue-thrusting by a modification of dentofacial growth using a non-surgical orthopedic treatment approach. Improvement of the vertical discrepancies on the affected side and canted occlusal plane as well as mandibular deviation were achieved with a functional orthopaedic approach...
October 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/28872989/orthodontic-treatment-in-conjunction-with-twin-bock-treatment-and-growth-hormone-therapy-in-silver-russell-syndrome
#4
Su-Jin Ko, Ji Young Seo, Yong-Dae Kwon, Kyounga Cheon, Jae Hyun Park
Silver-Russell syndrome (SRS) is a very rare genetic disorder characterized by intrauterine growth retardation, short stature, and typical craniofacial abnormalities including micrognathia. While growth hormone (GH) therapy in children with SRS significantly improves somatic growth, functional orthopedic treatment can also be effective in adolescents with mandibular deficiency. We report the effects of Phase 1 functional orthopedic treatment of a twin-block appliance in conjunction with GH administration in a 9-year-old boy with GH deficiency and SRS, and the result of the subsequent Phase 2 orthodontic treatment...
2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28576607/extensiometric-analysis-of-strain-in-craniofacial-bones-during-implant-supported-palatal-expansion
#5
Carlos Nelson Elias, Daniel Jogaib Fernandes, Denis Souza Zanivan, Yuri Resende Fonseca
Palatal expansion has several orthodontic and orthopedic applications, such as increasing maxillary transverse dimensions and correcting maxillary atresia, oral breathing, and skeletal cross-bites. Little is known about the strain to which craniofacial bones are submitted when a palatal expander is loaded. The objectives of the present work were to propose a new palatal bone-borne titanium device (expansion screw), to determine patterns of strain distribution in craniofacial bones during palatal expansion and to show the clinical results of a new palatal expander supported by implants...
December 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28511506/an-assessment-of-correlation-between-dermatoglyphic-patterns-and-sagittal-skeletal-discrepancies
#6
Susha Miriam George, Biju Philip, Deepika Madathody, Manu Mathew, Jose Paul, Johnson Prakash Dlima
INTRODUCTION: Investigators over years have been fascinated by dermatoglyphic patterns which has led to the development of dermatoglyphics as a science with numerous applications in various fields other than being the best and most widely used method for personal identification. AIM: To assess the correlation between dermatoglyphic patterns and sagittal skeletal discrepancies. MATERIALS AND METHODS: A total of 180 patients, aged 18-40 years, were selected from those who attended the outpatient clinic of the Deparment of Orthodontics and Dentofacial Orthopedics, Mar Baselios Dental College, Kothamangalam, Kerala, India...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28444016/frictionless-segmented-mechanics-for-controlled-space-closure
#7
Ildeu Andrade
Extraction spaces may be needed to achieve specific orthodontic goals of positioning the dentition in harmony with the craniofacial complex. However, the fundamental reality that determines the occlusion final position is the control exerted by the orthodontist while closing the extraction spaces. A specific treatment objective may require the posterior teeth to remain in a constant position anteroposteriorly as well as vertically, while the anterior teeth occupy the entire extraction site. Another treatment objective may require the opposite, or any number of intentional alternatives of extraction site closure...
February 2017: Dental Press Journal of Orthodontics
https://www.readbyqxmd.com/read/28415545/engineering-bone-regeneration-with-novel-cell-laden-hydrogel-microfiber-injectable-calcium-phosphate-scaffold
#8
Yang Song, Chi Zhang, Ping Wang, Lin Wang, Chunyun Bao, Michael D Weir, Mark A Reynolds, Ke Ren, Liang Zhao, Hockin H K Xu
Cell-based tissue engineering is promising to create living functional tissues for bone regeneration. The implanted cells should be evenly distributed in the scaffold, be fast-released to the defect and maintain high viability in order to actively participate in the regenerative process. Herein, we report an injectable calcium phosphate cement (CPC) scaffold containing cell-encapsulating hydrogel microfibers with desirable degradability that could deliver cells in a timely manner and maintain cell viability...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28328806/craniosynostosis-scheuermann-s-disease-and-intellectual-disability-resembling-shprintzen-goldberg-syndrome-a-report-on-a-family-over-4-generations-case-report
#9
Ali Al Kaissi, Zahra Marrakchi, Nabil M Nassib, Jochen Hofstaetter, Franz Grill, Rudolf Ganger, Susanne Gerit Kircher
RATIONALE: Craniosynostosis is a disorder characterized by premature fusion of cranial sutures with subsequent development of abnormal craniofacial contour associated with variable skeletal and extra-skeletal abnormalities. In this family syndromic type of craniosynostosis was recognized and the etiology behind diverse forms of deformities have been diagnosed. PATIENT CONCERNS: The negative impact of the disorder on the child and his family is enormous. Particularly when the diagnosis is late and little can be done...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28240815/antimicrobial-and-immunomodulatory-surface-functionalized-electrospun-membranes-for-bone-regeneration
#10
Asha Mathew, Cedryck Vaquette, Saeed Hashimi, Irani Rathnayake, Flavia Huygens, Dietmar W Hutmacher, Saso Ivanovski
Guided bone regeneration (GBR) is a surgical procedure utilizing occlusive membranes for providing space maintenance and enabling selective repopulation of the damaged area. While this technique is effective in regenerating bone, bacterial infiltration occurs frequently and can compromise the regenerative outcome. In this study, the authors describe the development and characterization of a GBR membrane made of medical grade polycaprolactone (mPCL) electrospun fibers with antibacterial and immunomodulatory properties...
May 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28169513/multilayer-nanoscale-encapsulation-of-biofunctional-peptides-to-enhance-bone-tissue-regeneration-in-vivo
#11
Piergiorgio Gentile, Ana Marina Ferreira, Jill T Callaghan, Cheryl A Miller, Joss Atkinson, Christine Freeman, Paul V Hatton
Bone tissue healing is a dynamic process that is initiated by the recruitment of osteoprogenitor cells followed by their migration, proliferation, differentiation, and development of a mineralizing extracellular matrix. The work aims to manufacture a functionalized porous membrane that stimulates early events in bone healing for initiating a regenerative cascade. Layer-by-layer (LbL) assembly is proposed to modify the surface of osteoconductive electrospun meshes, based on poly(lactic-co-glycolic acid) and nanohydroxyapatite, by using poly(allylamine hydrochloride) and poly(sodium 4-styrenesulfonate) as polyelectrolytes...
April 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28138909/colloidal-gels-with-extracellular-matrix-particles-and-growth-factors-for-bone-regeneration-in-critical-size-rat-calvarial-defects
#12
Jakob M Townsend, S Connor Dennis, Jonathan Whitlow, Yi Feng, Jinxi Wang, Brian Andrews, Randolph J Nudo, Michael S Detamore, Cory J Berkland
Colloidal gels encapsulating natural materials and exhibiting paste-like properties for placement are promising for filling complex geometries in craniofacial bone regeneration applications. Colloidal materials have demonstrated modest clinical outcomes as bone substitutes in orthopedic applications, but limited success in craniofacial applications. As such, development of a novel colloidal gel will fill a void in commercially available products for use in craniofacial reconstruction. One likely application for this technology is cranial reconstruction...
May 2017: AAPS Journal
https://www.readbyqxmd.com/read/28098961/angiogenic-and-osteogenic-regeneration-in-rats-via-calcium-phosphate-scaffold-and-endothelial-cell-coculture-with-hbmscs-hucmscs-hipsc-mscs-and-hesc-mscs
#13
Wenchuan Chen, Xian Liu, Qianmin Chen, Chongyun Bao, Liang Zhao, Zhimin Zhu, Hockin H K Xu
Angiogenesis is a limiting factor in regenerating large bone defects. The objective of this study was to investigate angiogenic and osteogenic effects of coculture on calcium phosphate cement (CPC) scaffold using human umbilical vein endothelial cells (hUVECs) and mesenchymal stem cells (MSCs) from different origins for the first time. hUVECs were cocultured with four types of cells: human umbilical cord MSCs (hUCMSCs), human bone marrow MSCs (hBMSCs), and MSCs from induced pluripotent stem cells (hiPSC-MSCs) and embryonic stem cells (hESC-MSCs)...
January 18, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28032345/zygomatic-bone-shape-in-intentional-cranial-deformations-a-model-for-the-study-of-the-interactions-between-skull-growth-and-facial-morphology
#14
S Ketoff, F Girinon, S Schlager, M Friess, T Schouman, P Rouch, R H Khonsari
Intentional cranial deformations (ICD) were obtained by exerting external mechanical constraints on the skull vault during the first years of life to permanently modify head shape. The repercussions of ICD on the face are not well described in the midfacial region. Here we assessed the shape of the zygomatic bone in different types of ICDs. We considered 14 non-deformed skulls, 19 skulls with antero-posterior deformation, nine skulls with circumferential deformation and seven skulls with Toulouse deformation...
April 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/27994432/presurgical-nasoalveolar-molding-a-boon-to-facilitate-the-surgical-repair-in-infants-with-cleft-lip-and-palate
#15
Prabhakar Ramasetty Attiguppe, Y M Karuna, Chandrashekar Yavagal, Saraswathi V Naik, B M Deepak, Rekhamani Maganti, Chaithanya G Krishna
Cleft lip and palate (CLP) is the most common congenital craniofacial anomaly. Rehabilitation of CLP generally requires a team approach. Alveolar and nasal reconstruction for these patients is a challenge for the reconstructive surgeon. Various procedures have been attempted to reduce the cleft gap, so as to obtain esthetic results postsurgically. The presurgical nasoalveolar molding (PNAM) technique, developed by Grayson, is a new approach to presurgical infant orthopedics. PNAM reduces the severity of the initial cleft alveolar and nasal deformity...
October 2016: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/27898256/comparative-study-of-the-physiotherapeutic-and-drug-protocol-and-low-level-laser-irradiation-in-the-treatment-of-pain-associated-with-temporomandibular-dysfunction
#16
COMPARATIVE STUDY
Marcos Fernando Xisto Braga Cavalcanti, Uoston Holder Silva, Ernesto Cesar Pinto Leal-Junior, Rodrigo A B Lopes-Martins, Rodrigo Labat Marcos, Rodney Capp Pallotta, Francesca Diomede, Oriana Trubiani, Natalia De Isla, Lucio Frigo
BACKGROUND: The temporomandibular joint (TMJ) is a structure of the craniofacial complex affected by neurological diseases. Orthopedic and musculoskeletal changes can also cause temporomandibular disorders (TMD) and pain. Low-level laser (LLL) therapy has been studied in the treatment of temporomandibular jaw (TMJ) dysfunction, and controversial results were obtained. OBJECTIVE: The objective of this work was comparing the physiotherapeutic and drug protocol (PDP) to LLL therapy in the treatment of pain associated with TMD...
December 2016: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/27881916/osseointegration-of-nanohydroxyapatite-or-nano-calcium-silicate-incorporated-polyetheretherketone-bioactive-composites-in-vivo
#17
Rui Ma, Zhifeng Yu, Songchao Tang, Yongkang Pan, Jie Wei, Tingting Tang
Polyetheretherketone (PEEK) exhibits appropriate biomechanical strength as well as good biocompatibility and stable chemical properties but lacks bioactivity and cannot achieve highly efficient osseointegration after implantation. Incorporating bioceramics into the PEEK matrix is a feasible approach for improving its bioactivity. In this study, nanohydroxyapatite (n-HA) and nano-calcium silicate (n-CS) were separately incorporated into PEEK to prepare n-HA/PEEK and n-CS/PEEK biocomposites, respectively, using a compounding and injection-molding technique, and the in vitro degradation characteristics were evaluated...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27836765/nasal-breathing-and-the-vertical-dimension-a-cephalometric-study
#18
Amal El Aouame, Asmaa Daoui, Farid El Quars
INTRODUCTION: The aim of this work was to perform a cephalometric analysis of the craniofacial parameters and natural head posture of mouth-breathers compared with control subjects, and to study the relationship between nose-breathing and the vertical dimension. MATERIAL AND METHODS: The headfilms taken at start of treatment of 53 cases (28 girls, 25 boys) aged 9 to 30 who consulted the dento-facial orthopedic department of the Ibn Rochd Casablanca dental consultation and treatment center were studied...
December 2016: International Orthodontics
https://www.readbyqxmd.com/read/27811389/hydrogel-fibers-encapsulating-human-stem-cells-in-an-injectable-calcium-phosphate-scaffold-for-bone-tissue-engineering
#19
Lin Wang, Ping Wang, Michael D Weir, Mark A Reynolds, Liang Zhao, Hockin H K Xu
Human induced pluripotent stem cells (hiPSCs), human embryonic stem cells (hESCs) and human umbilical cord mesenchymal stem cells (hUCMSCs) are exciting cell sources for use in regenerative medicine. There have been no reports on long hydrogel fibers encapsulating stem cells inside an injectable calcium phosphate cement (CPC) scaffold for bone tissue engineering. The objectives of this study were: (1) to develop a novel injectable CPC construct containing hydrogel fibers encapsulating cells for bone engineering, and (2) to investigate and compare cell viability, proliferation and osteogenic differentiation of hiPSC-MSCs, hESC-MSCs and hUCMSCs in injectable CPC...
November 4, 2016: Biomedical Materials
https://www.readbyqxmd.com/read/27726836/-normal-and-pathologic-mandible-development-practical-deductions-in-maxillo-dento-facial-orthopedics
#20
Jean-Michel Salagnac
INTRODUCTION: The mandible consists of different segments, each of which possess its own specific characteristics regarding emergence, ossification during growth and pathologies. Orthodontists need to be very familiar with these developmental anomalies if they are to avoid failure in their orthopedic or orthodontic treatments and in order to understand the reasons for the lack of success of "conventional" treatments. Each segment must develop correctly if the mandible is to achieve optimal development and occupy a normal position within the cranio-facial complex...
September 2016: L' Orthodontie Fran├žaise
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