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https://www.readbyqxmd.com/read/28741855/in-vivo-rescue-of-the-hematopoietic-niche-by-pluripotent-stem-cell-complementation-of-defective-osteoblast-compartments
#1
Rhiannon Chubb, James Oh, Alyssa K Riley, Takaharu Kimura, Sean M Wu, Joy Y Wu
Bone-forming osteoblasts play critical roles in supporting bone marrow hematopoiesis. Pluripotent stem cells (PSCs), including embryonic stem (ES) cells and induced pluripotent stem (iPS) cells, are capable of differentiating into osteoblasts. To determine the capacity of stem cells needed to rescue aberrant skeletal development and bone marrow hematopoiesis in vivo, we employed a skeletal complementation model. Mice deficient in Runx2, a master transcription factor for osteoblastogenesis, fail to form a mineralized skeleton and bone marrow...
July 25, 2017: Stem Cells
https://www.readbyqxmd.com/read/28741295/early-segmental-relaxation-abnormalities-in-hypertrophic-cardiomyopathy-for-differential-diagnostic-of-patients-with-left-ventricular-hypertrophy
#2
Christian Voigt, Julia Münch, Maxim Avanesov, Anna Suling, Katrin Witzel, Gunnar Lund, Monica Patten
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is characterized by asymmetric left ventricular hypertrophy (LVH). However, clinical signs can be subtle and differentiation from other causes of LVH is challenging. HYPOTHESIS: As diastolic dysfunction (DD) is an early sign in HCM, we aimed to find regional changes in relaxation pattern for differentiation from other entities of LVH. METHODS: In 148 patients (81 HCM, 55 arterial hypertension (AHT), 12 Fabry disease) and 63 healthy controls, relaxation patterns were assessed using regional tissue Doppler imaging...
July 24, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28741153/recovery-of-acl-function-after-dynamic-intraligamentary-stabilization-is-resultant-to-restoration-of-acl-integrity-and-scar-tissue-formation
#3
Atesch Ateschrang, Sufian S Ahmad, Ulrich Stöckle, Steffen Schroeter, Willem Schenk, Marc Daniel Ahrend
PURPOSE: Dynamic intraligamentary stabilization (DIS) is recognized as a ligament preserving technique for the treatment of acute anterior cruciate ligament (ACL) injuries. The aim of this study was to assess the integrity and morphology of the recovered ACL after DIS repair. METHODS: The cohort comprised 47 patients with an acute proximal ACL rupture undergoing DIS repair. All patients underwent diagnostic arthroscopy after a minimum postoperative interval of 6 months for semi-quantitative evaluation of ACL integrity, function and scar tissue formation...
July 24, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28740761/local-application-of-statins-significantly-reduced-hypertrophic-scarring-in-a-rabbit-ear-model
#4
Shengxian Jia, Ping Xie, Seok J Hong, Robert D Galiano, Thomas A Mustoe
BACKGROUND: We previously showed that intradermal injection of statins is a successful treatment for hypertrophic scarring. Topical application has many advantages over intradermal injection. In this study, we demonstrate the efficacy of topical statin treatment in reducing scar in our validated rabbit ear scar model. METHODS: Twenty New Zealand White rabbits were divided into 2 study groups, with 6 rabbits receiving 10 μm pravastatin intradermally at postoperative days 15, 18, and 21, and 14 rabbits receiving 0...
June 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28740644/the-hemodynamic-impact-of-acute-nasal-continuous-positive-airway-pressure-treatment-in-hypertrophic-cardiomyopathy-is-it-safe
#5
EDITORIAL
Bo Xu, Reena Mehra
No abstract text is available yet for this article.
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28740513/igf-1-gene-transfer-to-human-synovial-mscs-promotes-their-chondrogenic-differentiation-potential-without-induction-of-the-hypertrophic-phenotype
#6
Yasutoshi Ikeda, Morito Sakaue, Ryota Chijimatsu, David A Hart, Hidenori Otsubo, Kazunori Shimomura, Henning Madry, Tomoyuki Suzuki, Hideki Yoshikawa, Toshihiko Yamashita, Norimasa Nakamura
Mesenchymal stem cell- (MSC-) based therapy is a promising treatment for cartilage. However, repair tissue in general fails to regenerate an original hyaline-like tissue. In this study, we focused on increasing the expression levels for insulin-like growth factor-1 (IGF-1) to improve repair tissue quality. The IGF-1 gene was introduced into human synovial MSCs with a lentiviral vector and examined the levels of gene expression and morphological status of MSCs under chondrogenic differentiation condition using pellet cultures...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28740379/peg-coated-gold-nanoparticles-attenuate-%C3%AE-adrenergic-receptor-mediated-cardiac-hypertrophy
#7
Yuhui Qiao, Baoling Zhu, Aiju Tian, Zijian Li
Gold nanoparticles (AuNPs) are widely used as a drug delivery vehicle, which can accumulate in the heart through blood circulation. Therefore, it is very important to understand the effect of AuNPs on the heart, especially under pathological conditions. In this study, we found that PEG-coated AuNPs attenuate β-adrenergic receptor (β-AR)-mediated acute cardiac hypertrophy and inflammation. However, both isoproterenol, a non-selective β-AR agonist, and AuNPs did not induce cardiac function change or cardiac fibrosis...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28739175/sudden-infant-death-from-neonate-carnitine-palmitoyl-transferase-ii-deficiency
#8
Si-Hao Du, Fu Zhang, Yan-Geng Yu, Chuan-Xiang Chen, Hui-Jun Wang, Dong-Ri Li
A full-term female baby born to parents who gave birth three years prior to a girl who survived only 31h postpartum died 36h after birth. An autopsy showed that the heart was markedly hypertrophic (32g). Microscopically, the myocardium, liver and kidney cells exhibited extensive vacuolar degeneration. Sudan III staining was positive in cardiac muscle, liver and kidney tissue. Tandem mass spectrometry analysis revealed that the deceased patient had a carnitine palmitoyl transferase II (CPT2) deficiency or a carnitine-acylcarnitine translocase deficiency...
June 27, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28738492/-percutaneous-transluminal-septal-myocardial-ablation-by-microsphere-embolisation-for-a-patient-with-hypertrophic-obstructive-cardiomyophthy
#9
G Q Lin, M F Wu, J M Lin
No abstract text is available yet for this article.
July 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28738217/association-between-an-indel-polymorphism-in-the-3-utr-of-col1a2-and-the-risk-of-sudden-cardiac-death-in-chinese-populations
#10
Zhixia Yin, Yadong Guo, Jianhua Zhang, Qing Zhang, Lijuan Li, Shouyu Wang, Chaoqun Wang, Yan He, Shaohua Zhu, Chengtao Li, Suhua Zhang, Lagabaiyila Zha, Jifeng Cai, Bin Luo, Yuzhen Gao
Sudden cardiac death (SCD) describes the unexpected natural death from a cardiac cause within a short time period. Compelling evidence suggests the involvement of host genetic factors in SCD etiology. Identification of genetic variations predisposed to SCD enables genetic testing that may contribute to SCD diagnosis and risk stratification. Previous studies have suggested that dysregulation of pro-alpha2 chain of type I collagen, encoded by collagen type I alpha 2 chain (COL1A2) gene, was involved in cardiac disorders such as myocardial infarction, hypertrophic cardiomyopathy and atherosclerosis...
July 19, 2017: Legal Medicine
https://www.readbyqxmd.com/read/28737122/preserved-heart-function-after-left-ventricular-pressure-overload-in-adult-mice-subjected-to-neonatal-cardiac-hypoplasia
#11
K Heinecke, A Heuser, F Blaschke, C Jux, L Thierfelder, J-D Drenckhahn
Intrauterine growth restriction in animal models reduces heart size and cardiomyocyte number at birth. Such incomplete cardiomyocyte endowment is believed to increase susceptibility toward cardiovascular disease in adulthood, a phenomenon referred to as developmental programming. We have previously described a mouse model of impaired myocardial development leading to a 25% reduction of cardiomyocyte number in neonates. This study investigated the response of these hypoplastic hearts to pressure overload in adulthood, applied by abdominal aortic constriction (AAC)...
July 24, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28736850/progressive-ataxia-and-palatal-tremor-two-autopsy-cases-of-a-novel-tauopathy
#12
Andrew F Gao, Achinoam Faust-Socher, Maryam Al-Murshed, Marc R Del Bigio, Anthony E Lang, David G Munoz
BACKGROUND: Sporadic progressive ataxia and palatal tremor is a rare syndrome characterized by mid- to late-adult-onset symptomatic palatal tremor and slowly progressive cerebellar ataxia. To date, there has been only one autopsy report, which described a novel 4-repeat tauopathy with hypertrophic olivary degeneration and tau-positive inclusions in olivary neurons and dystrophic neuritic processes termed glomeruloid bodies. We report on 2 additional autopsy cases. METHODS: Sections from selected paraffin-embedded brain regions were stained with hematoxylin and eosin/Luxol fast blue and processed for phosphorylated tau, 3-repeat tau, 4-repeat tau, neurofilament, glial fibrillary acid protein, phosphorylated α-synuclein, phosphorylated TAR DNA-binding protein 43, beta-amyloid, and p62 immunohistochemistry...
July 24, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28736272/rheumatic-paraneoplastic-syndromes-a-clinical-link-between-malignancy-and-autoimmunity
#13
Bernhard Manger, Georg Schett
Paraneoplastic syndromes are rare but can have enormous clinical impact on diagnosis and outcome of neoplastic diseases. The rheumatologist should be familiar with a few typical musculoskeletal manifestations of malignancies to be able to diagnose them early for a timely initiation of anti-tumour therapies. This review describes the characteristic features of various paraneoplastic arthritides and vasculitides, cancer-associated myositis, hypertrophic osteoarthropathy, and tumour-induced osteomalacia. In addition, the current knowledge about underlying pathomechanisms of these syndromes is discussed...
July 20, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28735352/long-noncoding-rna-expression-profiles-in-chondrogenic-and-hypertrophic-differentiation-of-mouse-mesenchymal-stem-cells
#14
Zhen Cao, Song Huang, Jianmei Li, Yun Bai, Ce Dou, Chuan Liu, Fei Kang, Xiaoshan Gong, Haibin Ding, Tianyong Hou, Shiwu Dong
Long noncoding RNAs (lncRNAs) are important regulators for a variety of biological processes. Chondrogenic differentiation of mesenchymal stem cells (MSCs) is a crucial stage in chondrogenesis while chondrocyte hypertrophy is related to endochondral ossification and osteoarthritis. However, the effects of lncRNAs on chondrogenic and hypertrophic differentiation of mouse MSCs are unclear. To explore the potential mechanisms of lncRNAs during chondrogenesis and chondrocyte hypertrophy, microarray was performed to investigate the expression profiles of lncRNA and mRNA in MSCs, pre-chondrocytes, and hypertrophic chondrocytes...
July 22, 2017: Functional & Integrative Genomics
https://www.readbyqxmd.com/read/28735292/pathogenesis-of-hypertrophic-cardiomyopathy-is-mutation-rather-than-disease-specific-a-comparison-of-the-cardiac-troponin-t-e163r-and-r92q-mouse-models
#15
Cecilia Ferrantini, Raffaele Coppini, Josè Manuel Pioner, Francesca Gentile, Benedetta Tosi, Luca Mazzoni, Beatrice Scellini, Nicoletta Piroddi, Annunziatina Laurino, Lorenzo Santini, Valentina Spinelli, Leonardo Sacconi, Pieter De Tombe, Rachel Moore, Jil Tardiff, Alessandro Mugelli, Iacopo Olivotto, Elisabetta Cerbai, Chiara Tesi, Corrado Poggesi
BACKGROUND: In cardiomyocytes from patients with hypertrophic cardiomyopathy, mechanical dysfunction and arrhythmogenicity are caused by mutation-driven changes in myofilament function combined with excitation-contraction (E-C) coupling abnormalities related to adverse remodeling. Whether myofilament or E-C coupling alterations are more relevant in disease development is unknown. Here, we aim to investigate whether the relative roles of myofilament dysfunction and E-C coupling remodeling in determining the hypertrophic cardiomyopathy phenotype are mutation specific...
July 22, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28734889/subaortic-membrane-and-hypertrophic%C3%A2-obstructive-cardiomyopathy-in-the-cardiac-catheterization-lab
#16
Musa A Sharkawi, Talhat Azemi, Brett Duncan, Immad Sadiq
No abstract text is available yet for this article.
July 19, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28734448/alternative-strategy-for-biventricular-assist-device-in-an-infant-with-hypertrophic-cardiomyopathy
#17
John C Dykes, Olaf Reinhartz, Christopher S Almond, Vamsi Yarlagadda, Jenna Murray, David N Rosenthal, Katsuhide Maeda
We report an infant with hypertrophic cardiomyopathy who underwent biventricular assist device placement with two 15-mL Berlin Heart EXCOR pediatric ventricular assist devices using an alternative atrial cannulation strategy. The systemic circulation was supported by left atrium (LA) to aorta cannulation. The LA was accessed through the right atrium by extending a 6-mm EXCOR cannula with a Gore-Tex graft connected to an atrial septal defect. The pulmonary circulation was supported with cannulation of the right atrium to pulmonary artery...
August 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28734434/the-first-operation-for-apical-hypertrophic-cardiomyopathy-dr-dwight-mcgoon-1972
#18
Anita Nguyen, Hartzell V Schaff, William R Miranda, A Jamil Tajik
The first operation for apical hypertrophic cardiomyopathy (ApHCM) was performed on September 7, 1972 by Dr Dwight McGoon at Mayo Clinic on a 16-year-old boy who was thought to have a cardiac neoplasm.
August 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28733069/pulmonary-hypertension-and-clinical-correlates-in-hypertrophic-cardiomyopathy
#19
Maria Beatrice Musumeci, Vittoria Mastromarino, Matteo Casenghi, Giacomo Tini, Pietro Francia, Antonello Maruotti, Antonella Romaniello, Damiano Magrì, Rosa Lillo, Carmen Adduci, Massimo Volpe, Camillo Autore
BACKGROUND: Pulmonary hypertension (PH) in patients with hypertrophic cardiomyopathy (HCM) has been investigated in a small number of studies. Purpose of this study was to assess the prevalence and its association with outcome in a population of consecutive HCM outpatients. METHODS: We retrospectively analyzed data of 361 consecutive HCM outpatients in whom echocardiographic measurements of pulmonary artery systolic pressure (PASP) were available at initial and most recent evaluation...
July 14, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28732555/hepatobiliary-scintigraphy-to-evaluate-liver-function-in-associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-liver-volume-overestimates-liver-function
#20
Pim B Olthof, Federico Tomassini, Pablo E Huespe, Stephanie Truant, François-René Pruvot, Roberto I Troisi, Carlos Castro, Erik Schadde, Rimma Axelsson, Ernesto Sparrelid, Roelof J Bennink, Rene Adam, Thomas M van Gulik, Eduardo de Santibanes
BACKGROUND: Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) induces a rapid and extensive increase in liver volume. The functional quality of this hypertrophic response has been called into question because ALPPS is associated with a substantial incidence of liver failure and high perioperative mortality. This multicenter study aimed to evaluate functional liver regeneration in contrast to volumetric liver regeneration in ALPPS, using technetium-99m hepatobiliary scintigraphy and computed tomography volumetry, respectively...
July 18, 2017: Surgery
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