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Imke H Bartelink, Arief Lalmohamed, Elisabeth M L van Reij, Christopher C Dvorak, Rada M Savic, Juliette Zwaveling, Robbert G M Bredius, Antoine C G Egberts, Marc Bierings, Morris Kletzel, Peter J Shaw, Christa E Nath, George Hempel, Marc Ansari, Maja Krajinovic, Yves Théorêt, Michel Duval, Ron J Keizer, Henrique Bittencourt, Moustapha Hassan, Tayfun Güngör, Robert F Wynn, Paul Veys, Geoff D E Cuvelier, Sarah Marktel, Robert Chiesa, Morton J Cowan, Mary A Slatter, Melisa K Stricherz, Cathryn Jennissen, Janel R Long-Boyle, Jaap Jan Boelens
BACKGROUND: Intravenous busulfan combined with therapeutic drug monitoring to guide dosing improves outcomes after allogeneic haemopoietic cell transplantation (HCT). The best method to estimate busulfan exposure and optimum exposure in children or young adults remains unclear. We therefore assessed three approaches to estimate intravenous busulfan exposure (expressed as cumulative area under the curve [AUC]) and associated busulfan AUC with clinical outcomes in children or young adults undergoing allogeneic HCT...
October 13, 2016: Lancet Haematology
Morgan Ballard, Florencia Jalikis, Gregor Krings, Rodney A Schmidt, Yunn-Yi Chen, Mara H Rendi, Suzanne M Dintzis, Kristin C Jensen, Robert B West, Richard K Sibley, Megan L Troxell, Kimberly H Allison
The 2013 CAP/ASCO HER2 Testing Guidelines Update modified HER2 FISH categories such that some cases with 'monosomy', 'co-amplification/polysomy', low-level increased HER2 signals or clustered heterogeneity now are considered amplified or equivocal. This study examines the frequency and clinico-pathologic characteristics of breast cancers with equivocal or 'non-classical' HER2 FISH results. Breast cancers (2001-2014) with HER2 FISH results, HER2 immunohistochemistry, ER, grade, and age from three institutions (Stanford, UCSF, UWMC) were collected...
October 14, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Christopher S Tran, Clare E Liddy, Dora M Liu, Amir Afkham, Erin J Keely
OBJECTIVE: To describe the impact of an eConsult service on access to endocrinologists along with its influence on changing primary care provider (PCP) course of action and referral behaviors. METHODS: Established in 2011, the Champlain BASE (Building Access to Specialist Care via eConsult) service allows PCPs to access specialist care in lieu of traditional face-to-face referrals. We conducted a cross-sectional study of eConsult cases submitted to endocrinologists by PCPs between April 15, 2011 and January 31, 2015...
October 2016: Endocrine Practice
Chuncheng Liu, Jessica Mao, Terrence Wong, Weiming Tang, Lai Sze Tso, Songyuan Tang, Ye Zhang, Wei Zhang, Yilu Qin, Zihuang Chen, Wei Ma, Dianming Kang, Haochu Li, Meizhen Liao, Katie Mollan, Michael Hudgens, Barry Bayus, Shujie Huang, Bin Yang, Chongyi Wei, Joseph D Tucker
INTRODUCTION: Crowdsourcing has been used to spur innovation and increase community engagement in public health programmes. Crowdsourcing is the process of giving individual tasks to a large group, often involving open contests and enabled through multisectoral partnerships. Here we describe one crowdsourced video intervention in which a video promoting condom use is produced through an open contest. The aim of this study is to determine whether a crowdsourced intervention is as effective as a social marketing intervention in promoting condom use among high-risk men who have sex with men (MSM) and transgender male-to-female (TG) in China...
October 3, 2016: BMJ Open
Leah S Richmond-Rakerd, Jacqueline M Otto, Wendy S Slutske, Cindy L Ehlers, Kirk C Wilhelmsen, Ian R Gizer
INTRODUCTION: Tobacco use is associated with variation at the 15q25 gene cluster and the Cytochrome P450 (CYP) genes CYP2A6 and CYP2B6. Despite the variety of outcomes associated with these genes, few studies have adopted a data-driven approach to defining tobacco use phenotypes for genetic association analyses. We used factor analysis to generate a tobacco use measure, explored its incremental validity over a simple indicator of tobacco involvement: cigarettes per day (CPD), and tested both phenotypes in a genetic association study...
September 23, 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
Yuanyang Zhang, Tie Bo Wu, Bernie J Daigle, Mitchell Cohen, Linda Petzold
BACKGROUND: Trauma is the leading cause of death between the ages of 1 to 44 in the United States. Blood loss is the primary cause of these deaths. The discrimination of states through which patients transition would be helpful in understanding the disease process, and in identification of critical states and appropriate interventions. Even though these states are strongly associated with patients' blood composition data, there has not been a way to directly identify them. Statistical tools such as hidden Markov models can be used to infer the discrete latent states from the blood composition data...
2016: BMC Medical Informatics and Decision Making
Archana Anantharaman, Terence Friedlander, David Lu, Rachel Krupa, Gayatri Premasekharan, Jeffrey Hough, Matthew Edwards, Rosa Paz, Karla Lindquist, Ryon Graf, Adam Jendrisak, Jessica Louw, Lyndsey Dugan, Sarah Baird, Yipeng Wang, Ryan Dittamore, Pamela L Paris
BACKGROUND: While programmed death 1 (PD-1) and programmed death-ligand 1 (PD-L1) checkpoint inhibitors have activity in a proportion of patients with advanced bladder cancer, strongly predictive and prognostic biomarkers are still lacking. In this study, we evaluated PD-L1 protein expression on circulating tumor cells (CTCs) isolated from patients with muscle invasive (MIBC) and metastatic (mBCa) bladder cancer and explore the prognostic value of CTC PD-L1 expression on clinical outcomes...
2016: BMC Cancer
Rahul C Deo
BACKGROUND: -Truncating mutations in the giant sarcomeric gene Titin are the most common type of genetic alteration in dilated cardiomyopathy (DCM). Detailed studies have amassed a wealth of information regarding truncating variant position in cases and controls. Nonetheless, considerable confusion exists as to how to interpret the pathogenicity of these variants, hindering our ability to make useful recommendations to patients. METHODS AND RESULTS: -Building on our recent discovery of a conserved internal promoter within the Titin gene, we sought to develop an integrative statistical model to explain the observed pattern of TTN truncation variants in DCM patients and population controls...
September 13, 2016: Circulation. Cardiovascular Genetics
Mahmoud Abdelwahab Ali, Wei-Feng Li, Jing-Houng Wang, Chih-Che Lin, Ying-Ju Chen, Ting-Lung Lin, Tsan-Shiun Lin, Sheng-Nan Lu, Chih-Chi Wang, Chao-Long Chen
BACKGROUND: Currently, there is no definitive management for hepatocellular carcinoma (HCC) intrahepatic recurrence (IHR) after primary resection (PR). The aim of this study was to analyze the outcomes of three modalities for patients who received curative PR and had IHR within the University of California San Francisco (UCSF) criteria. METHODS: Between 2003 and 2010, patients with IHR after PR were treated with salvage liver transplantation (SLT), re-resection (RR) or local ablation (LA)...
October 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Pauline Filippou, Anobel Odisho, Krishna Ramaswamy, Manint Usawachintachit, Weiguo Hu, Jianxing Li, Thomas Chi
INTRODUCTION: To assess the effect of a hands-on ultrasound training session to teach urologic trainees ultrasound-guided percutaneous needle placement. MATERIALS AND METHODS: University of California, San Francisco (UCSF) urology residentes completed a time trial, placing a needle into a phantom model target under ultrasound guidance. Participants were randomized into three educational exposure groups: Group 1's time trial occurred prior to any teaching intervention, group 2's after experiencing a hands-on training module, and group 3's after exposure to both the training module and one-on-one attending feedback...
July 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
David A Edmondson, Erin E Karski, Ayano Kohlgruber, Harsha Koneru, Katherine K Matthay, Shelly Allen, Christine L Hartmann, Leif E Peterson, Steven G DuBois, Matthew A Coleman
Calculating internal dose from therapeutic radionuclides currently relies on estimates made from multiple radiation exposure measurements, converted to absorbed dose in specific organs using the Medical Internal Radiation Dose (MIRD) schema. As an alternative biodosimetric approach, we utilized gene expression analysis of whole blood from patients receiving targeted radiotherapy. Collected blood from patients with relapsed or refractory neuroblastoma who received (131)I-labeled metaiodobenzylguanidine ((131)I-mIBG) at the University of California San Francisco (UCSF) was used to compare calculated internal dose with the modulation of chosen gene expression...
September 2016: Radiation Research
Matthew P Mulé, Gabriel N Mannis, Brent L Wood, Jerald P Radich, Jimmy Hwang, Nestor R Ramos, Charalambos Andreadis, Lloyd Damon, Aaron C Logan, Thomas G Martin, Christopher S Hourigan
We report here the largest study to date of adult patients with acute myeloid leukemia (AML) tested for measurable residual disease (MRD) at the time of autologous hematopoietic cell transplantation (auto-HCT). Seventy-two adult patients who underwent transplantation between 2004 and 2013 at a single academic medical center (University of California San Francisco) were eligible for this retrospective study based on availability of cryopreserved granulocyte colony-stimulating factor (GCSF)-mobilized autologous peripheral blood progenitor cell (PBPC) leukapheresis specimens ("autografts")...
November 2016: Biology of Blood and Marrow Transplantation
Michał Grąt, Karolina M Wronka, Jan Stypułkowski, Emil Bik, Maciej Krasnodębski, Łukasz Masior, Zbigniew Lewandowski, Karolina Grąt, Waldemar Patkowski, Marek Krawczyk
BACKGROUND: Combination of the University of California, San Francisco (UCSF) and the up-to-7 criteria with alpha-fetoprotein (AFP) cutoff of 100 ng/ml was proposed as the Warsaw expansion of the Milan criteria in selection of hepatocellular cancer (HCC) patients for liver transplantation. The purpose of this retrospective study was to validate this proposal. METHODS: A total of 240 HCC patients after liver transplantation were included. Recurrence-free survival and overall survival at 5 years were set as the primary and secondary outcome measures, respectively...
August 16, 2016: Annals of Surgical Oncology
Zhenglu Wang, Weihua Gong, Dawei Shou, Luzhou Zhang, Xiangqian Gu, Yuliang Wang, Dahong Teng, Hong Zheng
BACKGROUND This study aimed to determine whether patterns of tumor clonal origin in pluri-nodular hepatocellular carcinoma (PNHC) could serve as an indicator of tumor recurrence following liver transplantation. MATERIAL AND METHODS Tumor tissue samples from 60 PNHC patients who underwent liver transplantation were examined. The diagnosis of patients conformed to the University of California San Francisco (UCSF) standards for pluri-nodular hepatocellular carcinoma. We performed loss of heterozygosity tests at multiple microsatellite sites to determine the clonal origins of the tumors...
2016: Annals of Transplantation: Quarterly of the Polish Transplantation Society
Shingo Matsumoto
Tumors develop a characteristic microenvironment depending on their specific genetic mutations. The direct products of mutant genes and the resulting microenvironmental changes provoke metabolic changes in the tumor. If noninvasive imaging techniques including magnetic resonance imaging (MRI) could be used to detect such microenvironmental and metabolic changes in tumors, we might be able to provide more effective treatment strategies for individual tumors in patients. In addition to conventional imaging techniques, this review article introduces quantitative 3D oxygen imaging using electron paramagnetic resonance imaging (EPRI) and hyperpolarized (13)C metabolic MRI and shows how these imaging techniques can help to monitor and predict tumor response to various treatments including radiation therapy and antiangiogenic agents...
2016: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
S Bonaretti, N Vilayphiou, C M Chan, A Yu, K Nishiyama, D Liu, S Boutroy, A Ghasem-Zadeh, S K Boyd, R Chapurlat, H McKay, E Shane, M L Bouxsein, D M Black, S Majumdar, E S Orwoll, T F Lang, S Khosla, A J Burghardt
: In this study, we determined that operator positioning precision contributes significant measurement error in high-resolution peripheral quantitative computed tomography (HR-pQCT). Moreover, we developed software to quantify intra- and inter-operator variability and demonstrated that standard positioning training (now available as a web-based application) can significantly reduce inter-operator variability. INTRODUCTION: HR-pQCT is increasingly used to assess bone quality, fracture risk, and anti-fracture interventions...
July 30, 2016: Osteoporosis International
V Iremashvili, M Manoharan, D J Parekh, S Punnen
BACKGROUND: Our goal was to compare the ability of active surveillance (AS) criteria and preoperative nomograms to identify patients with pathologically low-risk prostate cancer. METHODS: The study cohort consisted of 402 radical prostatectomy patients with Gleason 6 prostate cancer on at least 10-core biopsy. In this group, we analyzed the ability of Kattan and Truong nomograms to select patients with Gleason 3+3 or 3+4 organ-confined prostate cancer, and compared it with that of AS criteria of John Hopkins (JH) and University of California at San Francisco (UCSF) medical centers, and Prostate Cancer Research International: Active Surveillance (PRIAS) study...
July 19, 2016: Prostate Cancer and Prostatic Diseases
Michael S Deiner, Thomas M Lietman, Stephen D McLeod, James Chodosh, Travis C Porco
IMPORTANCE: Internet-based search engine and social media data may provide a novel complementary source for better understanding the epidemiologic factors of infectious eye diseases, which could better inform eye health care and disease prevention. OBJECTIVE: To assess whether data from internet-based social media and search engines are associated with objective clinic-based diagnoses of conjunctivitis. DESIGN, SETTING, AND PARTICIPANTS: Data from encounters of 4143 patients diagnosed with conjunctivitis from June 3, 2012, to April 26, 2014, at the University of California San Francisco (UCSF) Medical Center, were analyzed using Spearman rank correlation of each weekly observation to compare demographics and seasonality of nonallergic conjunctivitis with allergic conjunctivitis...
September 1, 2016: JAMA Ophthalmology
Alok K Shah, Kim-Anh Lê Cao, Eunju Choi, David Chen, Benoît Gautier, Derek Nancarrow, David C Whiteman, Peter R Baker, Karl R Clauser, Robert J Chalkley, Nicholas A Saunders, Andrew P Barbour, Virendra Joshi, Michelle M Hill
This data article describes serum glycoprotein biomarker discovery and qualification datasets generated using lectin magnetic bead array (LeMBA) - mass spectrometry techniques, "Serum glycoprotein biomarker discovery and qualification pipeline reveals novel diagnostic biomarker candidates for esophageal adenocarcinoma" [1]. Serum samples collected from healthy, metaplastic Barrett׳s esophagus (BE) and esophageal adenocarcinoma (EAC) individuals were profiled for glycoprotein subsets via differential lectin binding...
June 2016: Data in Brief
Corinna Clio Zygourakis, Victoria Valencia, Chris Moriates, Christy Boscardin, Sereina Catschegn, Andrew Goldberg, Kevin Bozic, Kent Soo Hoo, Rosanna Wustrack, Lawrence H Pitts, Adams Dudley, Ralph Gonzales, Michael T Lawton
INTRODUCTION: Despite the large contribution of surgical expenses to rising health care costs, many surgeons have little knowledge of their operating room (OR) costs. The goal of OR SCORE (OR Surgical Cost Reduction) is to determine whether providing surgeons with cost feedback reduces OR costs. METHODS: We performed a prospective controlled trial from January to December 2015 at University of California San Francisco (UCSF). Each surgeon in the orthopedic, ear, nose, and throat, and neurosurgery departments received standardized scorecards on a monthly basis in 2015...
August 2016: Neurosurgery
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