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https://www.readbyqxmd.com/read/29768083/sebo-pharmacokinetics-a-proposed-percutaneous-sebum-egression-method
#1
Rasika Reddy, John Havens Cary, Akram Elmahdy, Howard Maibach
BACKGROUND/AIMS: The sebaceous gland is widely believed a critical factor in the pathogenesis of acne vulgaris. Although extensive studies document the ability of oral and topical treatments to improve acne, little is known about the quantification and mechanism of drug delivery via the sebaceous gland. A percutaneous egression method presents a way to study how drugs reaching the bloodstream can enter the skin. METHODS: A literature search was performed across databases (PubMed, Embase, and Google Scholar) and the University of California, San Francisco (UCSF) textbook library with relevant search terms...
May 16, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29761124/progranulin-levels-in-blood-in-alzheimer-s-disease-and-mild-cognitive-impairment
#2
Yonatan A Cooper, Daniel Nachun, Deepika Dokuru, Zhongan Yang, Anna M Karydas, Ginette Serrero, Binbin Yue, Adam L Boxer, Bruce L Miller, Giovanni Coppola
Objective: Changes in progranulin ( GRN ) expression have been hypothesized to alter risk for Alzheimer's disease (AD). We investigated the relationship between GRN expression in peripheral blood and clinical diagnosis of AD and mild cognitive impairment (MCI). Methods: Peripheral blood progranulin gene expression was measured, using microarrays from Alzheimer's ( n = 186), MCI ( n = 118), and control ( n = 204) subjects from the University of California San Francisco Memory and Aging Center (UCSF-MAC) and two independent published series (AddNeuroMed and ADNI)...
May 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29735971/functional-and-in-silico-assessment-of-gdf3-gene-variants-in-a-chinese-congenital-scoliosis-population
#3
Jia Chen, Xiaoxin Li, Yuchen Niu, Zhihong Wu, Guixing Qiu
BACKGROUND The present study aimed to evaluate the pathogenicity of 5 [i]GDF3[/i] gene variations using functional and [i]in silico[/i] assessment approaches in a Chinese congenital scoliosis population. MATERIAL AND METHODS We selected 13 patients carrying 5 variants from a congenital scoliosis cohort. The PCR products of samples were verified by Sanger sequencing. The data and sequence alignment were analyzed using Chromas and ClustalW. SIFT and PolyPhen-2 were used to predict the functional effects of each missense and amino acid substitutions...
May 8, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29707868/transarterial-chemoembolization-in-children-to-treat-unresectable-hepatocellular-carcinoma
#4
Krista E Weiss, Daniel Y Sze, Arun A Rangaswami, Carlos O Esquivel, Waldo Concepcion, Edward A Lebowitz, Nishita Kothary, Matthew P Lungren
Children with unresectable HCC have a dismal prognosis and few approved treatment options. TACE is an effective treatment option for adults with HCC, but experience in children is very limited. Retrospective analysis was performed of 8 patients aged 4-17 years (4 male, mean 12.5 years) who underwent TACE for unresectable HCC. Response to TACE was evaluated by change in AFP, RECIST and tumor volume, PRETEXT, and transplantation eligibility by UCSF and Milan criteria. Post-procedure mean follow-up was 8.2 years...
April 29, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29676697/the-transcortical-equatorial-approach-for-gliomas-of-the-mesial-temporal-lobe-techniques-and-functional-outcomes
#5
Ramin A Morshed, Jacob S Young, Seunggu J Han, Shawn L Hervey-Jumper, Mitchel S Berger
OBJECTIVE Many surgical approaches have been described for lesions within the mesial temporal lobe (MTL), but there are limited reports on the transcortical approach for the resection of tumors within this region. Here, the authors describe the technical considerations and functional outcomes in patients undergoing transcortical resection of gliomas of the MTL. METHODS Patients with a glioma (WHO grades I-IV) located within the MTL who had undergone the transcortical approach in the period between 1998 and 2016 were identified through the University of California, San Francisco (UCSF) tumor registry and were classified according to tumor location: preuncus, uncus, hippocampus/parahippocampus, and various combinations of the former groups...
April 20, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29625945/structural-and-functional-annotation-of-citrate-synthase-from-aspergillus-niger-anj-120
#6
Ghulam Mustafa, Rawaba Arif, Shazia Anwer Bukhari, Muhammad Ali, Sumaira Sharif, Asia Atta
Citrate synthase (CS) is involved in citric acid biosynthesis which is a well-established metabolic pathway. The condensation of acetyl-CoA with oxaloacetate is catalyzed by CS. Citric acid (CA) has a number of applications in pharmaceutical industry. CA in combination with bicarbonates is used as an effervescent in the preparations of tablets and powders. It has also been used as an anticoagulant and acidulant to form mild astringent. In current study, detailed structural and functional analyses of CS protein were carried out using various bioinformatics tools...
March 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29599607/model-combining-pre-transplant-tumor-biomarkers-and-tumor-size-shows-more-utility-in-predicting-hepatocellular-carcinoma-recurrence-and-survival-than-the-balad-models
#7
Nicha Wongjarupong, Gabriela M Negron-Ocasio, Roongruedee Chaiteerakij, Benyam D Addissie, Essa A Mohamed, Kristin C Mara, William S Harmsen, J Paul Theobald, Brian E Peters, Joseph G Balsanek, Melissa M Ward, Nasra H Giama, Sudhakar K Venkatesh, Denise M Harnois, Michael R Charlton, Hiroyuki Yamada, Alicia Algeciras-Schimnich, Melissa R Snyder, Terry M Therneau, Lewis R Roberts
AIM: To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma (HCC) patients after liver transplant. METHODS: BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein (AFP), Lens culinaris agglutinin-reactive AFP (AFP-L3), and des-gamma-carboxyprothrombin (DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios (HR) for recurrence and death were calculated...
March 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29546392/tobacco-industry-promotional-strategies-targeting-american-indians-alaska-natives-and-exploiting-tribal-sovereignty
#8
Lauren K Lempert, Stanton A Glantz
Introduction: American Indians/Alaska Natives have the highest commercial tobacco use in the United States, resulting in higher tobacco-caused deaths and diseases than the general population. Some American Indians/Alaska Natives use commercial tobacco for ceremonial as well as recreational uses. Because federally-recognized Tribal lands are sovereign, they are not subject to state cigarette taxes and smokefree laws. This study analyzes tobacco industry promotional efforts specifically targeting American Indians/Alaska Natives and exploiting Tribal lands to understand appropriate policy responses in light of American Indians'/Alaska Natives' unique sovereign status and culture...
March 12, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29539389/droids-1-20-a-gui-based-pipeline-for-gpu-accelerated-comparative-protein-dynamics
#9
Gregory A Babbitt, Jamie S Mortensen, Erin E Coppola, Lily E Adams, Justin K Liao
Traditional informatics in comparative genomics work only with static representations of biomolecules (i.e., sequence and structure), thereby ignoring the molecular dynamics (MD) of proteins that define function in the cell. A comparative approach applied to MD would connect this very short timescale process, defined in femtoseconds, to one of the longest in the universe: molecular evolution measured in millions of years. Here, we leverage advances in graphics-processing-unit-accelerated MD simulation software to develop a comparative method of MD analysis and visualization that can be applied to any two homologous Protein Data Bank structures...
March 13, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29527266/survival-outcomes-of-liver-transplantation-for-hepatocellular-carcinoma-in-patients-with-normal-high-and-very-high-preoperative-alpha-fetoprotein-levels
#10
Wong Hoi She, Albert Chi Yan Chan, Tan To Cheung, Chung Mau Lo, Kenneth Siu Ho Chok
AIM: To investigate the impact of alpha-fetoprotein (AFP) on long-term recurrence rate and overall survival and we also aimed to define the level of AFP leading to a higher risk of disease recurrence and affecting patient survival. METHODS: Data of adult patients who received liver transplant (LT) for hepatocellular carcinoma (HCC) at our hospital from January 2000 to December 2013 were reviewed. Reviewed data included demographic characteristics, preoperative AFP level, operative details, follow-up details, and survival outcomes...
February 27, 2018: World Journal of Hepatology
https://www.readbyqxmd.com/read/29469048/results-of-liver-transplantation-for-hepatocellular-carcinoma-in-a-multicenter-latin-american-cohort-study
#11
Federico Piñero, Paulo Costa, Yuri L Boteon, Sergio Hoyos Duque, Sebastian Marciano, Margarita Anders, Adriana Varón, Alina Zerega, Jaime Poniachik, Alejandro Soza, Martín Padilla Machaca, Josemaría Menéndez, Rodrigo Zapata, Mario Vilatoba, Linda Muñoz, Martín Maraschio, Martín Fauda, Lucas McCormack, Adrian Gadano, Ilka Sf Boin, Jose H Parente García, Marcelo Silva
BACKGROUND AND AIMS: Heterogeneous data has been reported regarding liver transplantation (LT) for hepatocellular carcinoma (HCC) in Latin America. We aimed to describe treatment during waiting list, survival and recurrence of HCC after LT in a multicenter study from Latin America. MATERIAL AND METHODS: Patients with HCC diagnosed prior to transplant (cHCC) and incidentally found in the explanted liver (iHCC) were included. Imaging-explanted features were compared in cHCC (non-discordant if pre and post-LT were within Milan, discordant if pre-LT was within and post-LT exceeding Milan)...
March 1, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29453245/early-vs-late-age-at-onset-frontotemporal-dementia-and-frontotemporal-lobar-degeneration
#12
Sang Won Seo, Marie-Pierre Thibodeau, David C Perry, Alice Hua, Manu Sidhu, Isabel Sible, Jose Norberto S Vargas, Stephanie E Gaus, Gil D Rabinovici, Katherine D Rankin, Adam L Boxer, Joel H Kramer, Howard J Rosen, Maria Luisa Gorno-Tempini, Lea T Grinberg, Eric J Huang, Stephen J DeArmond, John Q Trojanowski, Bruce L Miller, William W Seeley
OBJECTIVE: To examine clinicopathologic correlations in early vs late age at onset frontotemporal dementia (FTD) and frontotemporal lobar degeneration (FTLD). METHODS: All patients were clinically evaluated and prospectively diagnosed at the UCSF Memory and Aging Center. Two consecutive series were included: (1) patients with a clinically diagnosed FTD syndrome who underwent autopsy (cohort 1) and (2) patients with a primary pathologic diagnosis of FTLD, regardless of the clinical syndrome (cohort 2)...
March 20, 2018: Neurology
https://www.readbyqxmd.com/read/29449270/internship-experiences-contribute-to-confident-career-decision-making-for-doctoral-students-in-the-life-sciences
#13
Alexandra M Schnoes, Anne Caliendo, Janice Morand, Teresa Dillinger, Michelle Naffziger-Hirsch, Bruce Moses, Jeffery C Gibeling, Keith R Yamamoto, Bill Lindstaedt, Richard McGee, Theresa C O'Brien
The Graduate Student Internships for Career Exploration (GSICE) program at the University of California, San Francisco (UCSF), offers structured training and hands-on experience through internships for a broad range of PhD-level careers. The GSICE program model was successfully replicated at the University of California, Davis (UC Davis). Here, we present outcome data for a total of 217 PhD students participating in the UCSF and UC Davis programs from 2010 to 2015 and 2014 to 2015, respectively. The internship programs at the two sites demonstrated comparable participation, internship completion rates, and overall outcomes...
2018: CBE Life Sciences Education
https://www.readbyqxmd.com/read/29445252/implications-of-measurement-assay-type-in-design-of-hiv-experiments
#14
LaMont Cannon, Aditya Jagarapu, Cesar A Vargas-Garcia, Michael J Piovoso, Ryan Zurakowski
Time series measurements of circular viral episome (2-LTR) concentrations enable indirect quantification of persistent low-level Human Immunodeficiency Virus (HIV) replication in patients on Integrase-Inhibitor intensified Combined Antiretroviral Therapy (cART). In order to determine the magnitude of these low level infection events, blood has to be drawn from a patients at a frequency and volume that is strictly regulated by the Institutional Review Board (IRB). Once the blood is drawn, the 2-LTR concentration is determined by quantifying the amount of HIV DNA present in the sample via a PCR (Polymerase Chain Reaction) assay...
December 2017: Proceedings of the ... IEEE Conference on Decision & Control
https://www.readbyqxmd.com/read/29417649/-addressed-to-you-not-as-a-smoker%C3%A2-but-as-a-doctor-doctor-targeted-cigarette-advertisements-in-jama
#15
Robert K Jackler, Noel F Ayoub
BACKGROUND AND AIM: During the mid-20th century tobacco companies placed advertisements in medical journals to entice physicians to smoke their brand and, more importantly, to recommend it to their patients. They have been little studied, in part because advertising sections in medical journals are almost universally discarded before binding. This study aimed to define the themes and techniques used in doctor-targeted tobacco advertisements that appeared in American medical journals in the mid-20th century and determine the motivations and tactics of the tobacco industry in engaging the medical profession in this way...
February 7, 2018: Addiction
https://www.readbyqxmd.com/read/29379634/life-as-an-early-career-researcher-interview-with-minhaj-sirajuddin
#16
Minhaj Sirajuddin
Minhaj Sirajuddin talks to Francesca Lake, Head of Open Access Publishing. Minhaj Sirajuddin is currently an Assistant Investigator at the Institute for Stem Cell Biology and Regenerative Medicine (InStem), Bangalore, India. His lab works on understanding biological motility mediated by cytoskeleton elements using biophysics and cell biology. Previously his tenures were at UCSF (CA, USA) for his postdoctoral work and the Max Planck Institute (Dortmund, Germany) for his PhD. Minhaj is a recipient of Wellcome Trust - DBT India Alliance Intermediate Fellowship and the EMBO Young Investigator Award...
February 2018: Future Science OA
https://www.readbyqxmd.com/read/29377168/technical-note-feasibility-study-of-titanium-markers-in-choroidal-melanoma-localization-for-proton-beam-radiation-therapy
#17
Inder K Daftari, Jeanne M Quivey, Jennifer S Chang, Kavita K Mishra
PURPOSE: The purpose of this study is to explore the feasibility of the use of titanium fiducial markers to minimize the metallic artifact seen with tantalum markers which causes significant distortion on postoperative orbital CT scans. METHOD: We designed and constructed the titanium markers in the shop of Crocker Nuclear Laboratory, UC Davis, CA. The markers were placed on an eyeball phantom. The eyeball was inserted into the Rando phantom in the orbital space...
March 2018: Medical Physics
https://www.readbyqxmd.com/read/29374661/multicentre-validation-of-a-sepsis-prediction-algorithm-using-only-vital-sign-data-in-the-emergency-department-general-ward-and-icu
#18
Qingqing Mao, Melissa Jay, Jana L Hoffman, Jacob Calvert, Christopher Barton, David Shimabukuro, Lisa Shieh, Uli Chettipally, Grant Fletcher, Yaniv Kerem, Yifan Zhou, Ritankar Das
OBJECTIVES: We validate a machine learning-based sepsis-prediction algorithm ( InSight ) for the detection and prediction of three sepsis-related gold standards, using only six vital signs. We evaluate robustness to missing data, customisation to site-specific data using transfer learning and generalisability to new settings. DESIGN: A machine-learning algorithm with gradient tree boosting. Features for prediction were created from combinations of six vital sign measurements and their changes over time...
January 26, 2018: BMJ Open
https://www.readbyqxmd.com/read/29355911/the-brain-health-assessment-for-detecting-and-diagnosing-neurocognitive-disorders
#19
Katherine L Possin, Tacie Moskowitz, Sabrina J Erlhoff, Kirsten M Rogers, Erica T Johnson, Natasha Z R Steele, Joseph J Higgins, Jordan Stiver, Andrea G Alioto, Sarah T Farias, Bruce L Miller, Katherine P Rankin
BACKGROUND/OBJECTIVES: Brief cognitive screens lack the sensitivity to detect mild cognitive impairment (MCI) or support differential diagnoses. The objective of this study was to validate the 10-minute, tablet-based University of California, San Francisco (UCSF) Brain Health Assessment (BHA) to overcome these limitations. DESIGN: Cross-sectional. SETTING: UCSF Memory and Aging Center. PARTICIPANTS: Older adults (N = 347) (neurologically healthy controls (n = 185), and individuals diagnosed with MCI (n = 99), dementia (n = 42), and as normal with concerns (n = 21))...
January 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29355423/the-evidence-for-caries-management-by-risk-assessment-cambra%C3%A2
#20
J D B Featherstone, B W Chaffee
A system for Caries Management by Risk Assessment (CAMBRA® ) has been developed in California. The purpose of this article is to summarize the science behind the methodology, the history of the development of CAMBRA, and the outcomes of clinical application. The CAMBRA caries risk assessment (CRA) tool for ages 6 y through adult has been used at the University of California, San Francisco (UCSF), for 14 y, and outcome studies involving thousands of patients have been conducted. Three outcomes assessments, each on different patient cohorts, demonstrated a clear relationship between CAMBRA-CRA risk levels of low, moderate, high, and extreme with cavitation or lesions into dentin (by radiograph) at follow-up...
February 2018: Advances in Dental Research
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