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https://www.readbyqxmd.com/read/28069527/liver-transplantation-for-advanced-hepatocellular-carcinoma-after-downstaging-without-up-front-stage-restrictions
#1
William C Chapman, Sandra Garcia-Aroz, Neeta Vachharajani, Kathryn Fowler, Nael Saad, Yiing Lin, Jason Wellen, Benjamin Tan, Adeel S Khan, Majella Doyle
BACKGROUND: The incidence of HCC continues to increase dramatically worldwide. Liver transplantation (LT) is now standard and optimal treatment for patients with HCC in the setting of cirrhosis, but only for tumors within Milan criteria (MC). In patients presenting beyond Milan, locoregional therapy (LRT) may downstage to within-Milan for consideration of LT. While controversial, the current study aims to evaluate the outcomes of LT in patients presenting with advanced stage HCC who underwent downstaging and compare to patients who meet Milan criteria at presentation...
January 6, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28001101/palatal-fistula-risk-after-primary-palatoplasty-a-retrospective-comparison-of-a-humanitarian-organization-and-tertiary-hospitals
#2
Kimberly M Daniels, Emily Yang Yu, Rebecca G Maine, Yin Heng, Li Yang, Bing Shi, D Scott Corlew, William Y Hoffman, George A Gregory
BACKGROUND:   Humanitarian surgical organizations provide palatoplasties for patients without access to surgical care. Few organizations have evaluated the outcomes of these trips. This study evaluates the palatal fistula rate in patients from two cohorts in rural China and one in the United States. METHODS:   This study compared the odds of fistula formation among three cohorts whose palates were repaired between 2005 and 2009. One cohort included 97 Chinese patients operated on by teams from the United States and Canada under the auspices of Resurge International...
December 21, 2016: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/27986989/cyclops-lesions-detected-by-mri-are-frequent-findings-after-acl-surgical-reconstruction-but-do-not-impact-clinical-outcome-over-2%C3%A2-years
#3
Luca Facchetti, Benedikt J Schwaiger, Alexandra S Gersing, Julio Brandao Guimaraes, Lorenzo Nardo, Sharmila Majumdar, Benjamin C Ma, Thomas M Link, Xiaojuan Li
OBJECTIVES: To assess the impact of cyclops lesions with MRI in patients treated for anterior cruciate ligament (ACL) tears on clinical outcome. METHODS: In 113 patients (age 29.8 ± 10.5y; 55 females; BMI 24.8 ± 3.7 kg/m(2)) with complete ACL tear, 3 T-MRI scans were obtained before, 6-months, 1-year (n = 75) and 2-years (n = 33) after ACL reconstruction. Presence and volume of cyclops lesions were assessed. Clinical outcomes were measured using the Knee injury and Osteoarthritis Outcome Score (KOOS) and differences between time points (∆KOOS) were calculated...
December 16, 2016: European Radiology
https://www.readbyqxmd.com/read/27968894/hiv-self-testing-among-high-risk-men-who-have-sex-with-men-in-china-a-cross-sectional-study
#4
Yilu Qin, Fengying Liu, Weiming Tang, Songyuan Tang, Chuncheng Liu, Jessica Mao, Chongyi Wei, Joseph Tucker
BACKGROUND: HIV self-testing holds great promise for reaching high-risk key populations who do not access facility-based services, but it has rarely been evaluated outside of structured research settings. HIV self-testing is a process by which a person takes and interprets a test. We aimed to characterise implementation of unsupervised HIV self-testing among men who have sex with men (MSM) in China. METHODS: We undertook a nationwide online survey of MSM in November, 2015, in China...
October 2016: Lancet
https://www.readbyqxmd.com/read/27943639/genetic-prion-disease-experience-of-a-rapidly-progressive-dementia-center-in-the-united-states-and-a-review-of-the-literature
#5
REVIEW
Leonel T Takada, Mee-Ohk Kim, Ross W Cleveland, Katherine Wong, Sven A Forner, Ignacio Illán Gala, Jamie C Fong, Michael D Geschwind
Although prion diseases are generally thought to present as rapidly progressive dementias with survival of only a few months, the phenotypic spectrum for genetic prion diseases (gPrDs) is much broader. The majority have a rapid decline with short survival, but many patients with gPrDs present as slowly progressive ataxic or parkinsonian disorders with progression over a few to several years. A few very rare mutations even present as neuropsychiatric disorders, sometimes with systemic symptoms such as gastrointestinal disorders and neuropathy, progressing over years to decades...
January 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/27888318/toward-improving-the-fetal-diagnosis-of-coarctation-of-the-aorta
#6
Meaghan Beattie, Shabnam Peyvandi, Suguna Ganesan, Anita Moon-Grady
Coarctation of the aorta (CoA) is the most common ductal-dependent lesion missed on neonatal exam screening. Prenatal diagnosis of CoA improves outcomes through early initiation of prostaglandin. Fetal echocardiographic parameters including 2D and Doppler findings have been studied as predictive measures for fetal diagnosis of CoA, but diagnosis rates remain variable. A comprehensive set of predictor variables was applied to fetuses suspected of CoA to analyze which parameters were associated with postnatal CoA...
November 25, 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27850851/1215-intrahospital-transport-of-icu-patients-clinician-perceptions-and-proposed-solutions
#7
Amie Lencioni, Kelly Timothy, Hildy Schell-Chaple, Kendall Gross, David Shimabukuro, Angela Lipshutz, Denise Barchas
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27850834/1198-target-rass-an-example-of-leveraging-the-ehr-to-standardize-goal-based-interventions
#8
Kendall Gross, Jennifer Schwarz, Raman Khanna, Hildy Schell-Chaple, Michael Gropper, Angela Lipshutz, Matthew Aldrich
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27835710/external-validation-of-the-liverpool-uveal-melanoma-prognosticator-online
#9
Sarah W DeParis, Azzam Taktak, Antonio Eleuteri, Wayne Enanoria, Heinrich Heimann, Sarah E Coupland, Bertil Damato
Purpose: To validate the Liverpool Uveal Melanoma Prognosticator Online (LUMPO) in a cohort of patients treated at the University of California-San Francisco (UCSF). Methods: A retrospective chart review was performed of 390 patients treated between 2002 and 2007 for choroidal melanoma at UCSF. Similar patients (n = 1175) treated at the Liverpool Ocular Oncology Centre (LOOC) were included in the study. The data were analyzed using the model previously developed for LUMPO, an online prognostication tool combining multiple prognostic factors...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27826556/living-donor-liver-transplantation-for-hepatocellular-carcinoma-achieves-better-outcomes
#10
REVIEW
Chih-Che Lin, Chao-Long Chen
Liver transplantation (LT) for hepatocellular carcinoma (HCC) at Kaohsiung Chang Gung Memorial Hospital mainly relies on live donor LT (LDLT). Owing to taking the risk of LD, we are obligated to adopt strict selection criteria for HCC patients and optimize the pre-transplant conditions to ensure a high disease-free survival similar to those without HCC, even better than deceased donor LT (DDLT). Better outcomes are attributed to excellent surgical results and optimal patient selection. The hospital mortality of primary and salvage LDLT are lower than 2% in our center...
October 2016: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/27825633/survival-analysis-of-sirolimus-based-immunosuppression-in-liver-transplantation-in-patients-with-hepatocellular-carcinoma
#11
Shi-Lei Xu, Ying-Cai Zhang, Guo-Ying Wang, Qin Yang, Bo Liu, Jian Zhang, Hua Li, Gen-Shu Wang, Yang Yang, Gui-Hua Chen
AIM: To investigate the effect of a sirolimus-based immunosuppressive protocol on tumor recurrence and survival after liver transplantation (LT) in hepatocellular carcinoma (HCC) patients. METHODS: We retrospectively analyzed 142 HCC patients who underwent LT in our hospital from January 2006 to January 2012. The patients were divided into the sirolimus (SRL) group (62 cases) and non-sirolimus (control) group (80 cases). Disease-free survival (DFS) and tumor-bearing survival after tumor recurrence were compared using the Kaplan-Meier method...
December 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27785435/emphysematous-pyelonephritis-the-impact-of-urolithiasis-on-disease-severity
#12
Thomas H Sanford, Frank Myers, Thomas Chi, Herman S Bagga, Andrew G Taylor, Marshall L Stoller
BACKGROUND: Emphysematous pyelonephritis is a severe infection of the kidney associated with formation of gas in the renal parenchyma and/or collecting system. The purpose of this study was to evaluate outcomes of patients with emphysematous pyelonephritis in a contemporary cohort and to evaluate the impact of urolithiasis on disease severity. METHODS: A search of all imaging reports at University of California San Francisco (UCSF) for the term "emphysematous pyelonephritis" was undertaken from 2003-2014...
October 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/27773831/kidney-transplantation-of-highly-sensitized-recipients-under-the-new-kidney-allocation-system-a-reflection-from-five-different-transplant-centers-across-the-united-states
#13
Ronald F Parsons, Jayme E Locke, Robert R Redfield, Garrett R Roll, Matthew H Levine
Deceased donor kidney allocation was reorganized in the United States to address several problems, including the highly sensitized patients disadvantaged with large, diverse repertoires of antibodies. Here, five transplant surgeons review their center's experience with the new allocation changes: highlighting areas of accomplishment, opportunities for improvement and, in some cases, stark differences in practice. Across these five centers the highly sensitized patients (CPRA ⩾98%) range from 5.5 to 9.2% of the 12,364 candidates on their collective waitlist...
October 20, 2016: Human Immunology
https://www.readbyqxmd.com/read/27746112/association-of-busulfan-exposure-with-survival-and-toxicity-after-haemopoietic-cell-transplantation-in-children-and-young-adults-a-multicentre-retrospective-cohort-analysis
#14
Imke H Bartelink, Arief Lalmohamed, Elisabeth M L van Reij, Christopher C Dvorak, Rada M Savic, Juliette Zwaveling, Robbert G M Bredius, Antoine C G Egberts, Marc Bierings, Morris Kletzel, Peter J Shaw, Christa E Nath, George Hempel, Marc Ansari, Maja Krajinovic, Yves Théorêt, Michel Duval, Ron J Keizer, Henrique Bittencourt, Moustapha Hassan, Tayfun Güngör, Robert F Wynn, Paul Veys, Geoff D E Cuvelier, Sarah Marktel, Robert Chiesa, Morton J Cowan, Mary A Slatter, Melisa K Stricherz, Cathryn Jennissen, Janel R Long-Boyle, Jaap Jan Boelens
BACKGROUND: Intravenous busulfan combined with therapeutic drug monitoring to guide dosing improves outcomes after allogeneic haemopoietic cell transplantation (HCT). The best method to estimate busulfan exposure and optimum exposure in children or young adults remains unclear. We therefore assessed three approaches to estimate intravenous busulfan exposure (expressed as cumulative area under the curve [AUC]) and associated busulfan AUC with clinical outcomes in children or young adults undergoing allogeneic HCT...
November 2016: Lancet Haematology
https://www.readbyqxmd.com/read/27739440/-non-classical-her2-fish-results-in-breast-cancer-a-multi-institutional-study
#15
Morgan Ballard, Florencia Jalikis, Gregor Krings, Rodney A Schmidt, Yunn-Yi Chen, Mara H Rendi, Suzanne M Dintzis, Kristin C Jensen, Robert B West, Richard K Sibley, Megan L Troxell, Kimberly H Allison
The 2013 CAP/ASCO HER2 Testing Guidelines Update modified HER2 FISH categories such that some cases with 'monosomy', 'co-amplification/polysomy', low-level increased HER2 signals or clustered heterogeneity now are considered amplified or equivocal. This study examines the frequency and clinico-pathologic characteristics of breast cancers with equivocal or 'non-classical' HER2 FISH results. Breast cancers (2001-2014) with HER2 FISH results, HER2 immunohistochemistry, ER, grade, and age from three institutions (Stanford, UCSF, UWMC) were collected...
October 14, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27732095/econsults-to-endocrinologists-improve-access-and-change-primary-care-provider-behavior
#16
Christopher S Tran, Clare E Liddy, Dora M Liu, Amir Afkham, Erin J Keely
OBJECTIVE: To describe the impact of an eConsult service on access to endocrinologists along with its influence on changing primary care provider (PCP) course of action and referral behaviors. METHODS: Established in 2011, the Champlain BASE (Building Access to Specialist Care via eConsult) service allows PCPs to access specialist care in lieu of traditional face-to-face referrals. We conducted a cross-sectional study of eConsult cases submitted to endocrinologists by PCPs between April 15, 2011 and January 31, 2015...
October 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27697868/comparing-the-effectiveness-of-a-crowdsourced-video-and-a-social-marketing-video-in-promoting-condom-use-among-chinese-men-who-have-sex-with-men-a-study-protocol
#17
Chuncheng Liu, Jessica Mao, Terrence Wong, Weiming Tang, Lai Sze Tso, Songyuan Tang, Ye Zhang, Wei Zhang, Yilu Qin, Zihuang Chen, Wei Ma, Dianming Kang, Haochu Li, Meizhen Liao, Katie Mollan, Michael Hudgens, Barry Bayus, Shujie Huang, Bin Yang, Chongyi Wei, Joseph D Tucker
INTRODUCTION: Crowdsourcing has been used to spur innovation and increase community engagement in public health programmes. Crowdsourcing is the process of giving individual tasks to a large group, often involving open contests and enabled through multisectoral partnerships. Here we describe one crowdsourced video intervention in which a video promoting condom use is produced through an open contest. The aim of this study is to determine whether a crowdsourced intervention is as effective as a social marketing intervention in promoting condom use among high-risk men who have sex with men (MSM) and transgender male-to-female (TG) in China...
October 3, 2016: BMJ Open
https://www.readbyqxmd.com/read/27663783/a-novel-tobacco-use-phenotype-suggests-the-15q25-and-19q13-loci-may-be-differentially-associated-with-cigarettes-per-day-and-tobacco-related-problems
#18
Leah S Richmond-Rakerd, Jacqueline M Otto, Wendy S Slutske, Cindy L Ehlers, Kirk C Wilhelmsen, Ian R Gizer
INTRODUCTION: Tobacco use is associated with variation at the 15q25 gene cluster and the Cytochrome P450 (CYP) genes CYP2A6 and CYP2B6. Despite the variety of outcomes associated with these genes, few studies have adopted a data-driven approach to defining tobacco use phenotypes for genetic association analyses. We used factor analysis to generate a tobacco use measure, explored its incremental validity over a simple indicator of tobacco involvement: cigarettes per day (CPD), and tested both phenotypes in a genetic association study...
September 23, 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/27658851/identification-of-disease-states-associated-with-coagulopathy-in-trauma
#19
Yuanyang Zhang, Tie Bo Wu, Bernie J Daigle, Mitchell Cohen, Linda Petzold
BACKGROUND: Trauma is the leading cause of death between the ages of 1 to 44 in the United States. Blood loss is the primary cause of these deaths. The discrimination of states through which patients transition would be helpful in understanding the disease process, and in identification of critical states and appropriate interventions. Even though these states are strongly associated with patients' blood composition data, there has not been a way to directly identify them. Statistical tools such as hidden Markov models can be used to infer the discrete latent states from the blood composition data...
2016: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/27658492/programmed-death-ligand-1-pd-l1-characterization-of-circulating-tumor-cells-ctcs-in-muscle-invasive-and-metastatic-bladder-cancer-patients
#20
Archana Anantharaman, Terence Friedlander, David Lu, Rachel Krupa, Gayatri Premasekharan, Jeffrey Hough, Matthew Edwards, Rosa Paz, Karla Lindquist, Ryon Graf, Adam Jendrisak, Jessica Louw, Lyndsey Dugan, Sarah Baird, Yipeng Wang, Ryan Dittamore, Pamela L Paris
BACKGROUND: While programmed death 1 (PD-1) and programmed death-ligand 1 (PD-L1) checkpoint inhibitors have activity in a proportion of patients with advanced bladder cancer, strongly predictive and prognostic biomarkers are still lacking. In this study, we evaluated PD-L1 protein expression on circulating tumor cells (CTCs) isolated from patients with muscle invasive (MIBC) and metastatic (mBCa) bladder cancer and explore the prognostic value of CTC PD-L1 expression on clinical outcomes...
2016: BMC Cancer
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