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https://www.readbyqxmd.com/read/27915311/can-we-stop-the-current-epidemic-of-blindness-from-retinopathy-of-prematurity
#1
Sourabh Dutta, Talkad Raghuveer, Anand Vinekar, Mangat Ram Dogra
Retinopathy of Prematurity (ROP) is a retinal vascular disease of the premature infant. There have been significant advances in the understanding of the pathogenesis, prevention, detection and treatment of severe ROP. In developed countries, all premature infants at risk for ROP are screened routinely based on national guidelines and treatment is prompt, resulting in good visual outcomes. Blindness from ROP is a rare event in these countries. However, there is an ongoing epidemic of ROP- induced blindness in India...
November 7, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27743509/remote-vital-parameter-monitoring-in-neonatology-robust-unobtrusive-heart-rate-detection-in-a-realistic-clinical-scenario
#2
Nikolai Blanik, Konrad Heimann, Carina Pereira, Michael Paul, Vladimir Blazek, Boudewijn Venema, Thorsten Orlikowsky, Steffen Leonhardt
Vital parameter monitoring of term and preterm infants during incubator care with self-adhesive electrodes or sensors directly positioned on the skin [e.g. photoplethysmography (PPG) for oxygen saturation or electrocardiography (ECG)] is an essential part of daily routine care in neonatal intensive care units. For various reasons, this kind of monitoring contains a lot of stress for the infants. Therefore, there is a need to measure vital parameters (for instance respiration, temperature, pulse, oxygen saturation) without mechanical or conductive contact...
December 1, 2016: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/27717357/perfusion-index-assessment-during-transition-period-of-newborns-an-observational-study
#3
Sezin Unal, Ebru Ergenekon, Selma Aktas, Serdar Beken, Nilgun Altuntas, Ebru Kazanci, Ferit Kulali, Ibrahim M Hirfanoglu, Esra Onal, Canan Turkyilmaz, Esin Koc, Yildiz Atalay
BACKGROUND: Perfusion index (PI) is becoming a part of clinical practice in neonatology to monitor peripheral perfusion noninvasively. Hemodynamic and respiratory changes occur in newborns during the transition period after birth in which peripheral perfusion may be affected. Tachypnea is a frequent symptom during this period. While some tachypneic newborns get well in less than 6 h and diagnosed as "delayed transition", others get admitted to intensive care unit which transient tachypnea of newborn (TTN) being the most common diagnosis among them...
October 7, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27682969/bronchopulmonary-dysplasia-old-becomes-new-again
#4
Colby L Day, Rita M Ryan
Despite the many advances in neonatology, bronchopulmonary dysplasia (BPD) continues to be a frustrating disease of prematurity. BPD is a disease which is defined oddly by its treatment rather than its pathophysiology, leading to frequently changing nomenclature which has widespread implications on our ability to both understand and follow the progression of BPD. As various treatment modalities for BPD were developed and a larger number of extremely preterm infants survived, the 'old' BPD based on lung injury from oxygen therapy and mechanical ventilation transitioned into a 'new' BPD focused more on the interruption of normal development...
September 28, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27667749/correlation-between-some-arterial-and-venous-blood-gas-parameters-in-healthy-newborn-martina-franca-donkey-foals-from-birth-to-96%C3%A2-hours-of-age
#5
A Carluccio, A Contri, A Gloria, M C Veronesi, M P Sfirro, S Parrillo, D Robbe
In neonatology, blood gas analysis is a useful tool in the evaluation of the health of newborns and plays a key role in early detection of critically ill subjects. Because blood gas analysis parameters have not previously been studied in any depth in donkey foals, this study was performed on 16 healthy Martina Franca donkey foals born after an uncomplicated delivery. Arterial and venous blood samples were collected at 5 minutes and at 12, 24, 72, and 96 hours of age. Blood gas analysis was performed by a portable analyzer, measuring arterial and venous total carbon dioxide, carbon dioxide partial pressure (pCO2), oxygen partial pressure (pO2), oxygen saturation (sO2), bicarbonate, base excess (BE), pH, and lactate (LT)...
August 31, 2016: Theriogenology
https://www.readbyqxmd.com/read/27400776/current-status-and-problems-concerning-neonatal-resuscitation-in-japan-in-2015
#6
Tetsuya Kunikata, Kayo Morita, Hayato Sakurai, Hiroko Kakei, Masakazu Honda, Masaki Wada, Hidenori Kawasaki, Masanori Tamura
BACKGROUND: The International Liaison Committee on Resuscitation (ILCOR) published Consensus 2015 in October, 2015. Thereafter, Japanese version of neonatal cardiopulmonary resuscitation programs was revised. Prior to the revision, we re-conducted questionnaire surveys in three types of medical facilities in January 2015. METHODS: Targeted groups included (1) 277 training hospitals authorized by the Japanese Society of Perinatal/Neonatal Medicine for training of physicians specialized in perinatal care (neonatology) in January 2015 (training hospitals, response rate: 70...
July 12, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27063086/why-do-premature-newborn-infants-display-elevated-blood-adenosine-levels
#7
Isabella Panfoli, Michela Cassanello, Matteo Bruschettini, Marina Colella, Roberto Cerone, Silvia Ravera, Daniela Calzia, Giovanni Candiano, Luca Ramenghi
Our preliminary data show high levels of adenosine in the blood of very low birth weight (VLBW) infants, positively correlating to their prematurity (i.e. body weight class). This prompted us to look for a mechanism promoting such impressive adenosine increase. We hypothesized a correlation with oxygen challenge. In fact, it is recognized that either oxygen lack or its excess contribute to the pathogenesis of the injuries of prematurity, such as retinopathy (ROP) and periventricular white matter lesions (PWMI)...
May 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/26940318/concepts-from-paediatric-extracorporeal-membrane-oxygenation-for-adult-intensivists
#8
Warwick Butt, Graeme MacLaren
Over the last 5 years, there has been a dramatic increase in the use of extracorporeal membrane oxygenation (ECMO) in adult patients with severe respiratory or cardiac failure. This contrasts to the use of the technology in neonatal and paediatric intensive care units, where it has been regarded as a standard of care for a number of conditions for over 25 years. Many innovations in ECMO circuitry or clinical management evolve first in one particular discipline and it may be helpful for individual clinicians to keep abreast of developments in ECMO across the entire age range, from neonatology to older adults...
December 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/26760414/newborn-respiratory-distress
#9
Christian L Hermansen, Anand Mahajan
Newborn respiratory distress presents a diagnostic and management challenge. Newborns with respiratory distress commonly exhibit tachypnea with a respiratory rate of more than 60 respirations per minute. They may present with grunting, retractions, nasal flaring, and cyanosis. Common causes include transient tachypnea of the newborn, respiratory distress syndrome, meconium aspiration syndrome, pneumonia, sepsis, pneumothorax, persistent pulmonary hypertension of the newborn, and delayed transition. Congenital heart defects, airway malformations, and inborn errors of metabolism are less common etiologies...
December 1, 2015: American Family Physician
https://www.readbyqxmd.com/read/26709767/retinopathy-of-prematurity-an-oxidative-stress-neonatal-disease
#10
William L Stone, Darshan Shah, Shawn M Hollinger
Proteomics is the global study of proteins in an organism or a tissue/fluid and is clinically relevant since most disease states are accompanied by specific alterations in an organism's proteome. This review focuses on the application of proteomics to neonatology with particular emphasis on retinopathy of prematurity (ROP), which is a disease in which oxidative stress plays a key pathophysiological role. Oxidative stress is a physiologically relevant redox imbalance caused by an excess of reactive oxygen (ROS) or reactive nitrogen oxide species (RNOS)...
January 1, 2016: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/26167395/safety-and-long-term-outcomes-with-high-flow-nasal-cannula-therapy-in-neonatology-a-large-retrospective-cohort-study
#11
Michael McQueen, Jorge Rojas, Shyan C Sun, Robert Tero, Kevin Ives, Frank Bednarek, Larry Owens, Kevin Dysart, George Dungan, Thomas H Shaffer, Thomas L Miller
OBJECTIVE: High flow nasal cannula therapy (HFT) has been shown to be similar to nasal continuous positive airway pressure (nCPAP) in neonates with respect to avoiding intubation. The objective of the current study is to determine if there are trends for adverse safety and long-term respiratory outcomes in very low birth weight infants (<1500 g) from centers using HFT as their primary mode of non-invasive respiratory support compared to data from the largest neonatal outcomes database (Vermont Oxford Network; VON)...
December 2014: Journal of Pulmonary & Respiratory Medicine
https://www.readbyqxmd.com/read/26143998/-oxidative-stress-after-preterm-birth-origins-biomarkers-and-possible-therapeutic-approaches
#12
REVIEW
C Yzydorczyk, D Mitanchez, C Buffat, I Ligi, I Grandvuillemin, F Boubred, U Simeoni
The survival of preterm babies has increased over the last few decades. However, disorders associated with preterm birth, known as oxygen radical diseases of neonatology, such as retinopathy, bronchopulmonary dysplasia, periventricular leukomalacia, and necrotizing enterocolitis are severe complications related to oxidative stress, which can be defined by an imbalance between oxidative reactive species production and antioxidant defenses. Oxidative stress causes lipid, protein, and DNA damage. Preterm infants have decreased antioxidant defenses in response to oxidative challenges, because the physiologic increase of antioxidant capacity occurs at the end of gestation in preparation for the transition to extrauterine life...
October 2015: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/26135948/delivery-room-management-of-elbw-infants-in-italy
#13
Francesca Rech Morassutti, Irene Satariano, Nicoletta Doglioni, Giulio Criscoli, Francesco Cavallin, Camilla Gizzi, Claudio Martano, Fabrizio Ciralli, Flaminia Torielli, Paolo E Villani, Sandra Di Fabio, Lorenzo Quartulli, Luigi Giannini, Daniele Trevisanuto, On Behalf Of Neonatal Resuscitation Study Group Italian Society Of Neonatology
In this article we evaluated the consistency of practice and the adherence to the International Guidelines in early delivery room management of ELBW infants in Italy. A polyethylene bag/wrap was used by 54 centres (55.1%). In Northern regions, one centre (2.5%) reported to use oxygen concentrations >40% to initiate positive pressure ventilation in ELBW infants. These proportions were higher in the Central (14.3%) and Southern (16.2%) areas. A T-piece device for positive pressure ventilation was widely used (77/97, 79...
June 29, 2015: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/26080662/-the-morbidities-of-extremely-preterm-and-extremely-low-birth-weight-infants-during-hospitalization
#14
(no author information available yet)
OBJECTIVE: Extremely preterm (EP) and extremely low birth weight infants (ELBWI) tended to suffer from some serious complications. How to treat and make them survive reflect the progress of perinatal medicine and neonatal treatment technology. But in our country, there was still lack of data analysis about the morbidities and interventions of large sample survey on such infants. This study was designed to survey the in-hospital morbidities of EP and ELBWI who had been admitted to neonatology departments...
May 2015: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/25721799/ketamine-attenuates-the-acth-response-to-hypoxia-in-late-gestation-ovine-fetus
#15
Eileen I Chang, Charles E Wood
BACKGROUND: Ketamine, a noncompetitive N-Methyl-D-aspartate (NMDA) receptor antagonist, is a commonly used dissociative anesthetic in neonatology. We have proposed that ketamine reduces fetal stress responsiveness to stimuli that involve reduced oxygen supply to the fetal brain. Previously, we have shown that ketamine inhibits plasma ACTH levels in late-gestation fetal sheep subjected to brachiocephalic artery occlusion (BCO), an ischemic hypoxia model that might activate some of the same direct and reflex responses as hypoxia...
2015: Neonatology
https://www.readbyqxmd.com/read/25593745/high-flow-nasal-cannula-recommendations-for-daily-practice-in-pediatrics
#16
REVIEW
Christophe Milési, Mathilde Boubal, Aurélien Jacquot, Julien Baleine, Sabine Durand, Marti Pons Odena, Gilles Cambonie
High-flow nasal cannula (HFNC) is a relatively new device for respiratory support. In pediatrics, HFNC use continues to increase as the system is easily set up and is well tolerated by patients. The use of nasal cannula adapted to the infant's nares size to deliver heated and humidified gas at high flow rates has been associated with improvements in washout of nasopharyngeal dead space, lung mucociliary clearance, and oxygen delivery compared with other oxygen delivery systems. HFNC may also create positive pharyngeal pressure to reduce the work of breathing, which positions the device midway between classical oxygen delivery systems, like the high-concentration face mask and continuous positive airway pressure (CPAP) generators...
2014: Annals of Intensive Care
https://www.readbyqxmd.com/read/25531535/intermittent-hypoxemia-bradycardia-and-the-developing-brain-how-much-is-too-much-commentary-on-m-b-schmid-et-al-cerebral-oxygenation-during-intermittent-hypoxemia-and-bradycardia-in-preterm-infants-neonatology-2015-107-137-146
#17
COMMENT
https://www.readbyqxmd.com/read/25510072/-pulmonary-hypertension-of-the-newborn-recent-advances-in-the-management-and-treatment
#18
REVIEW
L Vakrilova, P Radulova, St Hitrova, B Slancheva
Pulmonary hypertension of the newborn is a clinical syndrome with diverse etiology in which the transition from fetal circulation with high pulmonary vascular resistance to postnatal circulation with low pulmonary vascular resistance failed. The persistence of high pulmonary vascular pressure leads to right-left shunts and marked cyanosis. Despite of the advances in neonatology, the treatment of some forms of PPHN is often difficult and mortality rate remains high. In infants with PPHN appropriate interventions are critical to reverse hypoxemia, improve pulmonary and systemic perfusion and preserve end-organ function...
2014: Akusherstvo i Ginekologii︠a︡
https://www.readbyqxmd.com/read/25303135/high-frequency-oscillatory-ventilation-in-pediatrics-and-neonatology
#19
José Roberto Fioretto, Celso Moura Rebello
This article intends to review literature on high frequency oscillatory ventilation and describe its main clinical applications for children and neonates. Articles from the last 15 years were selected using MedLine and SciElo databases. The following key words were used: high frequency oscillatory ventilation, mechanical ventilation, acute respiratory distress syndrome, children, and new-born. The review describes high frequency oscillatory ventilation in children with acute respiratory distress syndrome, air leak syndrome, and obstructive lung disease...
March 2009: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/25220123/use-of-erythropoietin-is-associated-with-threshold-retinopathy-of-prematurity-rop-in-preterm-elbw-neonates-a-retrospective-cohort-study-from-two-large-tertiary-nicus-in-italy
#20
Paolo Manzoni, Luigi Memo, Michael Mostert, Elena Gallo, Roberta Guardione, Andrea Maestri, Onofrio Sergio Saia, Anna Opramolla, Sara Calabrese, Elena Tavella, Martina Luparia, Daniele Farina
BACKGROUND: Retinopathy of prematurity (ROP) is a multifactorial disease with evidence of many associated risk factors. Erythropoietin has been reported to be associated with this disorder in a murine model, as well as in humans in some single-center reports. We reviewed the data from two large tertiary NICUs in Italy to test the hypothesis that the use of erythropoietin may be associated with the development of the most severe stages of ROP in extremely low birth weight (ELBW) neonates...
September 2014: Early Human Development
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