keyword
https://read.qxmd.com/read/38528351/diagnostic-and-prognostic-value-of-pentraxin-3-interleukin-6-crp-and-procalcitonin-levels-in-patients-with-sepsis-and-septic-shock
#1
JOURNAL ARTICLE
B Palalıoğlu, S Erdoğan, G Atay, H C Tugrul, Ö F Özer
INTRODUCTION AND PURPOSE: In this prospective study, we aim to evaluate the effects of antibiotherapy on pentraxin-3 (PTX3), C-reactive protein (CRP), and interleukin-6 (IL-6) levels in patients with sepsis and septic shock. MATERIALS AND METHODS: In our study, CRP, procalcitonin, IL-6, and PTX3 levels at initial and 48 hours of the antibiotherapy of patients who were admitted to the pediatric intensive care unit (PICU) with the diagnosis of sepsis and septic shock between June 2020 and March 2021 were compared...
March 1, 2024: Nigerian Journal of Clinical Practice
https://read.qxmd.com/read/38518545/advances-in-pediatric-emergency-from-2023
#2
REVIEW
Joshua S Easter, Emily Rose
Most children receive emergency care by general emergency physicians and not in designated children's hospitals. There are unique considerations in the care of children that differ from the care of adults. Many management principles can be extrapolated from adult studies, but the unique pathophysiology of pediatric disease requires specialized attention and management updates. This article highlights ten impactful articles from the year 2023 whose findings can improve the care of children in the Emergency Department (ED)...
March 15, 2024: American Journal of Emergency Medicine
https://read.qxmd.com/read/38518030/the-evolution-of-sepsis-publications-and-global-productivity-a-bibliometric-analysis-between-1980-and-2020
#3
JOURNAL ARTICLE
Arzu Akdagli Ekici, Alperen Kisa, Semin Önder Turhan
The literature study was conducted by using the Web of Science (WoS) database, employing bibliometric analysis to examine all papers released from 1980 to 2020. The search was performed using the terms "sepsis, septicemia, septic shock" specifically within the titles of the publications. The findings of the literature research revealed a total of 51,725 articles. Out of the total number of publications, 26,896 articles were identified, accounting for 51.9% of the total. The bibliometric study revealed that the United States had the largest number of papers (8693), followed by China (2807), Germany (2299), France (1606), and the United Kingdom (1932)...
March 22, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38499323/assessment-of-adherence-to-the-2020-surviving-sepsis-campaign-guidelines-for-fluid-resuscitation-in-children-with-suspected-septic-shock-in-paediatric-emergency-departments-a-prospective-multicentre-study
#4
JOURNAL ARTICLE
Julian San Geroteo, Michael Levy, Marion Bailhache, Claire De Jorna, Elodie Privat, Oussama Gasmi, Maria Fuentes-Lopez, Yacine Laoudi, Mustapha Mazeghrane, Aline Malterre, Pauline Bories, Khaled Abdel Aal, Iozefina Arjoca, Jean Gaschignard, Davy Tanchaleune, Philippe Minodier, Fabien Audren, Tifanny Mazetier, Pauline Quagliaro, Florence Raimond, Soria Sieng, Blandine Robert, Delphine Wohrer, Nathalie De Suremain, Stéphane Dauger
BACKGROUND: Paediatric sepsis is the leading cause of death in children under 5 years. No studies have evaluated the application of the Surviving Sepsis Campaign 2020 (SSC-2020) guidelines in paediatric emergency departments (PEDs). OBJECTIVE: To assess physician adherence to the SSC-2020 fluid resuscitation guidelines in children with suspected septic shock in PEDs. METHODS: This was a prospective multicentre observational study conducted in 21 French hospitals over 5 sequential weeks, between November 2021 and March 2022...
March 18, 2024: Archives of Disease in Childhood
https://read.qxmd.com/read/38497960/severe-sepsis-during-treatment-for-childhood-leukemia-and-sequelae-among-adult-survivors
#5
JOURNAL ARTICLE
Kathryn P Goggin, Lu Lu, Danielle E Lee, Carrie R Howell, Deokumar Srivastava, Tara M Brinkman, Gregory T Armstrong, Nickhill Bhakta, Leslie L Robison, Mathew J Ehrhardt, Melissa M Hudson, Kevin R Krull, Ching-Hon Pui, Jeffrey Rubnitz, Kirsten K Ness, Joshua Wolf
IMPORTANCE: Children undergoing treatment for leukemia are at increased risk of severe sepsis, a dysregulated immune response to infection leading to acute organ dysfunction. As cancer survivors, they face a high burden of long-term adverse effects. The association between sepsis during anticancer therapy and long-term organ dysfunction in adult survivors of childhood cancer has not been examined. OBJECTIVE: To determine whether severe sepsis during therapy for leukemia in childhood is associated with subsequent chronic health conditions in adult survivors...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38496155/profile-of-acute-kidney-injury-in-the-pediatric-age-group-in-a-tertiary-care-hospital-a-prospective-observational-study
#6
JOURNAL ARTICLE
Ishan Kapil, Anil Kumar Goel, Manas R Sahoo
BACKGROUND AND OBJECTIVES: Acute kidney injury (AKI) is a menace in the pediatric intensive care unit (PICU) and is responsible for significant morbidity and mortality all over the world. There are limited data available on pediatric AKI in central India. Our primary objective is to determine the clinical, etiological, and outcome profile of AKI in the pediatric age group of 3 months to 15 years admitted to the All India Institute of Medical Sciences (AIIMS), Raipur. The secondary objective(s) is to predict the association of mortality in children diagnosed with AKI and to estimate the number of patients developing chronic kidney disease (CKD) at three-month follow-up...
February 2024: Curēus
https://read.qxmd.com/read/38491391/risk-factors-for-venous-thromboembolism-in-a-single-pediatric-intensive-care-unit-in-china
#7
JOURNAL ARTICLE
Jintuo Zhou, Yanting Zhu, Ying Liu, Hairong Zhan, Peiguang Niu, Huajiao Chen, Jinhua Zhang
BACKGROUND: Analyses of extensive, nationally representative databases indicate a rising prevalence of venous thromboembolism (VTE) among critically ill children. However, the majority of studies on childhood VTE have primarily concentrated on Caucasian populations in the United States and European countries. There is a lack of epidemiological studies on VTE in Chinese children. METHODS: We conducted a retrospective cohort study of data from the Pediatric Intensive Care (PIC) database...
March 15, 2024: Thrombosis Journal
https://read.qxmd.com/read/38471759/emergency-department-sepsis-triage-scoring-tool-elements-associated-with-hypotension-within-24-hours-in-children-with-fever-and-tachycardia
#8
JOURNAL ARTICLE
Alexandra H Baker, Vanessa M Mazandi, Jackson S Norton, Elliot Melendez
OBJECTIVE: Pediatric sepsis screening is becoming the standard of care for children presenting to the emergency department (ED) and has been shown to improve recognition of severe sepsis, but it is unknown if these screening tools can predict progression of disease. The objective of this study was to determine if any elements of a sepsis triage trigger tool were predictive of progression to hypotensive shock in children presenting to the ED with fever and tachycardia. METHODS: This study is a retrospective case-control study of children ≤18 years presenting to an ED with fever and tachycardia, comparing those who went on to develop hypotensive shock in the subsequent 24 hours (case) to those who did not (control)...
March 13, 2024: Pediatric Emergency Care
https://read.qxmd.com/read/38465952/biomarker-assessment-of-a-high-risk-data-driven-pediatric-sepsis-phenotype-characterized-by-persistent-hypoxemia-encephalopathy-and-shock
#9
JOURNAL ARTICLE
Mihir R Atreya, Tellen D Bennett, Alon Geva, E Vincent S Faustino, Colin M Rogerson, Riad Lutfi, Natalie Z Cvijanovich, Michael T Bigham, Jeffrey Nowak, Adam J Schwarz, Torrey Baines, Bereketeab Haileselassie, Neal J Thomas, Yuan Luo, L Nelson Sanchez-Pinto
OBJECTIVES: Identification of children with sepsis-associated multiple organ dysfunction syndrome (MODS) at risk for poor outcomes remains a challenge. We sought to the determine reproducibility of the data-driven "persistent hypoxemia, encephalopathy, and shock" (PHES) phenotype and determine its association with inflammatory and endothelial biomarkers, as well as biomarker-based pediatric risk strata. DESIGN: We retrained and validated a random forest classifier using organ dysfunction subscores in the 2012-2018 electronic health record (EHR) dataset used to derive the PHES phenotype...
March 11, 2024: Pediatric Critical Care Medicine
https://read.qxmd.com/read/38435306/case-report-metagenomics-next-generation-sequencing-in-the-diagnosis-of-septic-shock-due-to-fusobacterium-necrophorum-in-a-6-year-old-child
#10
Haiyang Zhang, Zhongqiang Liu, Yuanlin Guan, Deyuan Li, Hanmin Liu, Lingying Ruan
Fusobacterium necrophorum ( F. necrophorum ) infection is rare in pediatrics. In addition, the detection time of F. necrophorum by blood culture is long, and the positive rate is low. Infection with F. necrophorum bacilli usually follows rapid disease progression, resulting in high mortality. In previous reports of F. necrophorum -related cases, the most dangerous moment of the disease occurred after the appearance of Lemierre's syndrome. We report an atypical case of a 6-year-old female patient who developed septic shock within 24 h of admission due to F...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38403808/pattern-of-fluid-overload-and-its-impact-on-mortality-among-mechanically-ventilated-children-secondary-analysis-of-the-relisch-trial
#11
JOURNAL ARTICLE
Shubham Charaya, Suresh Kumar Angurana, Karthi Nallasamy, Arun Bansal, Jayashree Muralidharan
OBJECTIVES: To assess the pattern of fluid overload (FO) and its impact on mortality among mechanically ventilated children. METHODS: In this secondary analysis of an open-label randomized controlled trial (ReLiSCh trial, October 2020-September 2021), hemodynamically stable mechanically ventilated children (n = 100) admitted to a tertiary level pediatric intensive care unit (PICU) in North India were enrolled. The primary outcome was pattern of FO (FO% >10% and cumulative FO% from day 1-7); and secondary outcomes were pattern of FO among survivors and non-survivors, and prescription practices of maintenance fluid...
February 26, 2024: Indian Journal of Pediatrics
https://read.qxmd.com/read/38360044/high-dose-intravenous-immunoglobulin-versus-albumin-4-in-paediatric-toxic-shock-syndrome-a-randomised-controlled-feasibility-study
#12
JOURNAL ARTICLE
Aurélie Portefaix, Carole Dhelens, Morgan Recher, Fleur Cour-Andlauer, Jérôme Naudin, Guillaume Mortamet, Nicolas Joram, Pierre Tissières, Tiphanie Ginhoux, Behrouz Kassai, Florent Boutitie, Delphine Maucort-Boulch, Etienne Javouhey
PURPOSE: Toxic shock syndrome (TSS) is a rare disease responsible for significant morbidity and mortality. Intravenous immunoglobulin (IG) therapy in paediatric TSS could improve shock and organ failure, but more consistent efficacy and safety data are needed. Our objective was to determine whether a randomised clinical trial (RCT) assessing intravenous IG in TSS in children is feasible. METHODS: We performed a multicentre, feasibility, double-blind RCT assessing efficacy of high-dose intravenous IG versus albumin 4% (control group) within the first 12 hours of shock onset...
February 15, 2024: Archives of Disease in Childhood
https://read.qxmd.com/read/38353591/epidemiology-and-clinical-characteristics-of-pediatric-sepsis-in-picus-in-southwest-china-a-prospective-multicenter-study
#13
JOURNAL ARTICLE
Rong Liu, Zhicai Yu, Changxue Xiao, Feng Xu, Shufang Xiao, Juan He, Yan Shi, Yuanyuan Hua, Jimin Zhou, Guoying Zhang, Tao Wang, Jianyu Jiang, Daoxue Xiong, Yan Chen, Hongbo Xu, Hong Yun, Hui Sun, Tingting Pan, Rui Wang, Shuangmei Zhu, Dong Huang, Yujiang Liu, Yuhang Hu, Xinrui Ren, Mingfang Shi, Sizun Song, Jumei Luo, Gang He, Juan Zhang
OBJECTIVES: To describe the epidemiological characteristics of pediatric sepsis in Southwest China PICUs. DESIGN: A prospective, multicenter, and observational study. SETTING: Twelve PICUs in Southwest China. PATIENTS: The patients admitted to the PICU from April 1, 2022, to March 31, 2023. The age ranged from 28 days to 18 years. All patients met the criteria of severe sepsis or septic shock. INTERVENTIONS: None...
February 14, 2024: Pediatric Critical Care Medicine
https://read.qxmd.com/read/38353586/association-of-an-in-hospital-desirability-of-outcomes-ranking-scale-with-postdischarge-health-related-quality-of-life-a-secondary-analysis-of-the-life-after-pediatric-sepsis-evaluation
#14
JOURNAL ARTICLE
Grace E Logan, Russell K Banks, Ron Reeder, Kristen Miller, Peter M Mourani, Tellen D Bennett, Stephanie L Bourque, Kathleen L Meert, Jerry Zimmerman, Aline B Maddux
OBJECTIVES: To develop a desirability of outcome ranking (DOOR) scale for use in children with septic shock and determine its correlation with a decrease in 3-month postadmission health-related quality of life (HRQL) or death. DESIGN: Secondary analysis of the Life After Pediatric Sepsis Evaluation prospective study. SETTING: Twelve U.S. PICUs, 2013-2017. PATIENTS: Children (1 mo-18 yr) with septic shock. INTERVENTIONS: None...
February 14, 2024: Pediatric Critical Care Medicine
https://read.qxmd.com/read/38294838/impact-of-biologics-and-small-molecule-agents-on-postoperative-complications-in-inflammatory-bowel-disease-a-systematic-review
#15
JOURNAL ARTICLE
Kate E Lee, J Alexander Sizemore, Grace Kim, Bo Shen, Bruce E Sands
BACKGROUND: Patients with inflammatory bowel disease may require colectomy for severe disease unresponsive or refractory to pharmacological therapy. The question of the impact of biologic use on postoperative complications is a topic of active investigation. OBJECTIVE: A systematic literature review was performed to describe the current state of knowledge of the impact of perioperative biologic and tofacitinib use on postoperative complications in patients with inflammatory bowel disease...
January 31, 2024: Diseases of the Colon and Rectum
https://read.qxmd.com/read/38276999/echocardiographic-characteristics-in-neonates-with-septic-shock
#16
JOURNAL ARTICLE
Kumari Gunjan, Manoj Modi, Anup Thakur, Arun Soni, Satish Saluja
Clinical parameters used for hemodynamic assessment and titration of vasopressor therapy in neonates with septic shock have several limitations. Functional echocardiography is an emerging tool for bedside assessment of cardiac function and may be useful for diagnosis of shock and assessing the response to therapy. Data regarding echocardiographic parameters in neonates with shock is lacking. This prospective observational study was conducted in a Level III NICU with the primary objective of comparing echocardiographic characteristics of neonates with septic shock at diagnosis, following fluid boluses, and after maximum inotropic support [A1]...
January 26, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/38245897/development-and-validation-of-the-phoenix-criteria-for-pediatric-sepsis-and-septic-shock
#17
JOURNAL ARTICLE
L Nelson Sanchez-Pinto, Tellen D Bennett, Peter E DeWitt, Seth Russell, Margaret N Rebull, Blake Martin, Samuel Akech, David J Albers, Elizabeth R Alpern, Fran Balamuth, Melania Bembea, Mohammod Jobayer Chisti, Idris Evans, Christopher M Horvat, Juan Camilo Jaramillo-Bustamante, Niranjan Kissoon, Kusum Menon, Halden F Scott, Scott L Weiss, Matthew O Wiens, Jerry J Zimmerman, Andrew C Argent, Lauren R Sorce, Luregn J Schlapbach, R Scott Watson, Paolo Biban, Enitan Carrol, Kathleen Chiotos, Claudio Flauzino De Oliveira, Mark W Hall, David Inwald, Paul Ishimine, Michael Levin, Rakesh Lodha, Simon Nadel, Satoshi Nakagawa, Mark J Peters, Adrienne G Randolph, Suchitra Ranjit, Daniela Carla Souza, Pierre Tissieres, James L Wynn
IMPORTANCE: The Society of Critical Care Medicine Pediatric Sepsis Definition Task Force sought to develop and validate new clinical criteria for pediatric sepsis and septic shock using measures of organ dysfunction through a data-driven approach. OBJECTIVE: To derive and validate novel criteria for pediatric sepsis and septic shock across differently resourced settings. DESIGN, SETTING, AND PARTICIPANTS: Multicenter, international, retrospective cohort study in 10 health systems in the US, Colombia, Bangladesh, China, and Kenya, 3 of which were used as external validation sites...
February 27, 2024: JAMA
https://read.qxmd.com/read/38245889/international-consensus-criteria-for-pediatric-sepsis-and-septic-shock
#18
JOURNAL ARTICLE
Luregn J Schlapbach, R Scott Watson, Lauren R Sorce, Andrew C Argent, Kusum Menon, Mark W Hall, Samuel Akech, David J Albers, Elizabeth R Alpern, Fran Balamuth, Melania Bembea, Paolo Biban, Enitan D Carrol, Kathleen Chiotos, Mohammod Jobayer Chisti, Peter E DeWitt, Idris Evans, Cláudio Flauzino de Oliveira, Christopher M Horvat, David Inwald, Paul Ishimine, Juan Camilo Jaramillo-Bustamante, Michael Levin, Rakesh Lodha, Blake Martin, Simon Nadel, Satoshi Nakagawa, Mark J Peters, Adrienne G Randolph, Suchitra Ranjit, Margaret N Rebull, Seth Russell, Halden F Scott, Daniela Carla de Souza, Pierre Tissieres, Scott L Weiss, Matthew O Wiens, James L Wynn, Niranjan Kissoon, Jerry J Zimmerman, L Nelson Sanchez-Pinto, Tellen D Bennett
IMPORTANCE: Sepsis is a leading cause of death among children worldwide. Current pediatric-specific criteria for sepsis were published in 2005 based on expert opinion. In 2016, the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) defined sepsis as life-threatening organ dysfunction caused by a dysregulated host response to infection, but it excluded children. OBJECTIVE: To update and evaluate criteria for sepsis and septic shock in children...
January 21, 2024: JAMA
https://read.qxmd.com/read/38245695/the-association-between-prolonged-capillary-refill-time-and-microcirculation-changes-in-children-with-sepsis
#19
JOURNAL ARTICLE
Jaime Fernández-Sarmiento, Shirley Lamprea, Sofia Barrera, Lorena Acevedo, Catalina Duque, Manuela Trujillo, Valeria Aguirre, Carolina Jimenez
BACKGROUNDS: In children with sepsis, circulatory shock and multi-organ failure remain major contributors to mortality. Prolonged capillary refill time (PCRT) is a clinical tool associated with disease severity and tissue hypoperfusion. Microcirculation assessment with videomicroscopy represents a promising candidate for assessing and improving hemodynamic management strategies in children with sepsis. Particularly when there is loss of coherence between the macro and microcirculation (hemodynamic incoherence)...
January 20, 2024: BMC Pediatrics
https://read.qxmd.com/read/38245631/assessment-of-hemodynamic-dysfunction-in-septic-newborns-by-functional-echocardiography-a-systematic-review
#20
Flaminia Pugnaloni, Domenico Umberto De Rose, Florian Kipfmueller, Neil Patel, Maria Paola Ronchetti, Andrea Dotta, Pietro Bagolan, Irma Capolupo, Cinzia Auriti
BACKGROUND: Neonatal sepsis remains a leading cause of mortality in neonatal units. Neonatologist-performed echocardiography (NPE) offers the potential for early detection of sepsis-associated cardiovascular dysfunction. This review examines available echocardiographic findings in septic neonates. METHODS: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we systematically reviewed prospective observational, cross-sectional, case control, and cohort studies on septic newborns with echocardiographic assessments from PubMed, Scopus and Embase...
January 20, 2024: Pediatric Research
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