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Liver elastography

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https://www.readbyqxmd.com/read/29033488/automated-liver-elasticity-calculation-for-3d-mre
#1
Bogdan Dzyubak, Kevin J Glaser, Armando Manduca, Richard L Ehman
Magnetic Resonance Elastography (MRE) is a phase-contrast MRI technique which calculates quantitative stiffness images, called elastograms, by imaging the propagation of acoustic waves in tissues. It is used clinically to diagnose liver fibrosis. Automated analysis of MRE is difficult as the corresponding MRI magnitude images (which contain anatomical information) are affected by intensity inhomogeneity, motion artifact, and poor tissue- and edge-contrast. Additionally, areas with low wave amplitude must be excluded...
March 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/29030995/magnetic-resonance-elastography-is-as-accurate-as-liver-biopsy-for-liver-fibrosis-staging
#2
Hiroyuki Morisaka, Utaroh Motosugi, Shintaro Ichikawa, Tadao Nakazawa, Tetsuo Kondo, Satoshi Funayama, Masanori Matsuda, Tomoaki Ichikawa, Hiroshi Onishi
BACKGROUND: Liver MR elastography (MRE) is available for the noninvasive assessment of liver fibrosis; however, no previous studies have compared the diagnostic ability of MRE with that of liver biopsy. PURPOSE: To compare the diagnostic accuracy of liver fibrosis staging between MRE-based methods and liver biopsy using the resected liver specimens as the reference standard. STUDY TYPE: A retrospective study at a single institution. POPULATION: In all, 200 patients who underwent preoperative MRE and subsequent surgical liver resection were included in this study...
October 14, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29028279/liver-elastography-malignancy-prediction-lemp-score-for-noninvasive-characterization-of-focal-liver-lesions
#3
Ivica Grgurevic, Tomislav Bokun, Nermin N Salkic, Boris Brkljacic, Mirjana Vukelić-Markovic, Tajana Stoos-Veic, Gorana Aralica, Mislav Rakic, Tajana Filipec-Kanizaj, Annalisa Berzigotti
BACKGROUND & AIMS: To analyse elastographic characteristics of focal liver lesions (FLL)s and diagnostic performance of real-time two-dimensional shear-wave elastography (RT-2D-SWE) in order to differentiate benign and malignant FLLs. PATIENTS AND METHODS: Consecutive patients diagnosed with FLL by abdominal ultrasound (US) underwent RT-2D-SWE of FLL and non-infiltrated liver by intercostal approach over the right liver lobe. The nature of FLL was determined by diagnostic work-up, including at least one contrast-enhanced imaging modality (MDCT/MRI), check-up of target organs when metastatic disease was suspected and FLL biopsy in inconclusive cases...
October 13, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29023554/reproducibility-of-shear-wave-elastography-swe-in-patients-with-chronic-liver-disease
#4
Marcello Mancini, Angelo Salomone Megna, Monica Ragucci, Massimo De Luca, Giuseppina Marino Marsilia, Gerardo Nardone, Pietro Coccoli, Anna Prinster, Lorenzo Mannelli, Emilia Vergara, Serena Monti, Raffaele Liuzzi, Mariarosaria Incoronato
The presence of significant fibrosis is an indicator for liver disease staging and prognosis. The aim of the study was to determine reproducibility of real-time shear wave elastography using a hepatic biopsy as the reference standard to identify patients with chronic liver disease. Forty patients with chronic liver disease and 12 normal subjects received shear wave elastography performed by skilled operators. Interoperator reproducibility was studied in 29 patients. Fibrosis was evaluated using the Metavir score...
2017: PloS One
https://www.readbyqxmd.com/read/29018925/the-diagnostic-performance-of-shear-wave-elastography-for-liver-fibrosis-in-children-and-adolescents-a-systematic-review-and-diagnostic-meta-analysis
#5
Jeong Rye Kim, Chong Hyun Suh, Hee Mang Yoon, Jin Seong Lee, Young Ah Cho, Ah Young Jung
OBJECTIVE: To assess the diagnostic performance of shear-wave elastography for determining the severity of liver fibrosis in children and adolescents. METHODS: An electronic literature search of PubMed and EMBASE was conducted. Bivariate modelling and hierarchical summary receiver-operating-characteristic modelling were performed to evaluate the diagnostic performance of shear-wave elastography. Meta-regression and subgroup analyses according to the modality of shear-wave imaging and the degree of liver fibrosis were also performed...
October 10, 2017: European Radiology
https://www.readbyqxmd.com/read/28989092/advanced-liver-fibrosis-but-not-steatosis-is-independently-associated-with-albuminuria-in-chinese-patients-with-type-2-diabetes
#6
Ming-Wai Yeung, Grace Lai-Hung Wong, Kai Chow Choi, Andrea On-Yan Luk, Raymond Kwok, Sally She-Ting Shu, Anthony Wing-Hung Chan, Eric Siu Him Lau, Ronald Ching Wan Ma, Henry Lik-Yuen Chan, Juliana Chung-Ngor Chan, Vincent Wai-Sun Wong, Alice Pik-Shan Kong
BACKGROUND & AIMS: Increasing evidence suggests that non-alcoholic fatty liver disease (NAFLD) may be an independent risk factor for chronic kidney disease (CKD). Given the high prevalence of NAFLD among patients with diabetes who are also at risk for CKD, we aimed to investigate the association between NAFLD and albuminuria, a marker commonly found in diabetic nephropathy. METHODS: This study included a cohort of Chinese patients with type 2 diabetes from the Hong Kong Diabetes Registry recruited between March 2013 and May 2014...
October 5, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28988274/ultrasound-or-mr-elastography%C3%A2-of-liver-which-one-shall-i-use
#7
Meng Yin, Sudhakar K Venkatesh
Liver stiffness is now a well-established noninvasive biomarker for assessing fibrosis in chronic liver disease. MRI-based and ultrasound-based dynamic elastography techniques have been introduced for assessment of liver stiffness and useful in clinical staging of hepatic fibrosis. Several different elastography techniques are now available with each method having inherent strengths and limitations. The published literature generally indicates that MR elastography has a higher diagnostic performance and fewer technical failures than ultrasound-based elastography techniques in assessing hepatic fibrosis...
October 7, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28987693/association-between-non-hypervascular-hypointense-nodules-on-gadoxetic-acid-enhanced-mri-and-liver-stiffness-or-hepatocellular-carcinoma
#8
Jeong Ah Hwang, Tae Wook Kang, Young Kon Kim, Seong Hyun Kim, Yong Han Paik, Sang Yun Ha, Seonwoo Kim
PURPOSE: To assess the association between non-hypervascular hypointense nodules (NHHNs) on gadoxetic acid-enhanced magnetic resonance imaging (MRI) and liver stiffness (LS) in patients with chronic liver disease, and analyzed their progression to overt hepatocellular carcinoma (HCC). METHODS: Between August 2012 and March 2016, a total of 714 consecutive patients who had undergone transient elastography for LS measurement and gadoxetic acid-enhanced MRI were investigated...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28981243/-treatments-of-non-alcoholic-steatohepatitis
#9
T Gustot
Non-alcoholic fatty liver diseases are highly prevalent in Western countries and associated with insulin resitance and metabolic syndrome. Non-alcoholic steatohepatitis (NASH) is characterized by lobular inflammation and hepatocellular ballooning, and may be associated with liver fibrosis leading to cirrhosis and its complications as hepatocarcinoma. The presence of obesity, type 2 diabetes mellitus or increased liver enzymes in patients with metabolic syndrome should prompt non-invasive screening (liver ultrasound, serum markers and/or transient elastography) to predict steatosis, NASH and fibrosis...
2017: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/28970710/transient-elastography-fibroscan-in-patients-with-non-cirrhotic-portal-fibrosis
#10
Praveen Sharma, Rachit Agarwal, Shashi Dhawan, Naresh Bansal, Vikas Singla, Ashish Kumar, Anil Arora
BACKGROUND: Non-cirrhotic portal hypertension (NCPH) is a common cause of variceal bleed in developing countries. Transient elastography (TE) using Fibroscan is a useful technique for evaluation of fibrosis in patients with liver disease. There is a paucity of studies evaluating TE in patients with Non-cirrhotic portal fibrosis (NCPF) and none in Asian population. Aim of this study was to evaluate role of TE in NCPF. METHODS: Retrospective data of consecutive patients of NCPF as per Asian pacific association for the study of liver (APASL) guidelines were noted...
September 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/28970701/sofosbuvir-and-ribavirin-for-24-weeks-is-an-effective-treatment-option-for-recurrent-hepatitis-c-infection-after-living-donor-liver-transplantation
#11
Anil C Anand, Shaleen K Agarwal, Hitendra K Garg, Sudeep Khanna, Subhash Gupta
BACKGROUND: Recurrent hepatitis C virus (HCV) has been a serious problem after liver transplantation (LT). We report our experience of 24-week therapy with sofosbuvir (SOF) and ribavirin (RBV) in post-LT recurrent HCV in living donor liver transplantation (LDLT) setting in South Asia. METHODS: Data from all patients treated for post-transplantation HCV recurrence in a single center were analyzed. Treatment regimen was 24 weeks of SOF 400 mg daily and RBV (starting at 800 mg daily, increased as tolerated)...
September 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/28970146/association-between-hepatic-steatosis-measured-by-controlled-attenuation-parameter-and-fibrosis-burden-in-chronic-hepatitis-b
#12
Wai-Kay Seto, Rex Wh Hui, Lung-Yi Mak, James Fung, Ka-Shing Cheung, Kevin Sh Liu, Danny Ka-Ho Wong, Ching-Lung Lai, Man-Fung Yuen
BACKGROUND & AIMS: The interaction between chronic hepatitis B (CHB) and hepatic steatosis is poorly understood. We investigated whether measurement of controlled attenuation parameter (CAP), a non-invasive method to quantify steatosis, can assist in monitoring patients with CHB. METHODS: We performed transient elastography, to measure liver stiffness, and made CAP measurements in 1606 patients with CHB (898 treated with nucleoside analogues, for a median 75.4 months) in Hong Kong, from January 2015 through September 2016...
September 29, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28968053/improving-the-identification-and-monitoring-of-cirrhosis
#13
Margaret G Keane, Charles Hensher, Stephen P Pereira
Morbidity and mortality associated with cirrhosis are on the increase. In a recent UK cohort study the incidence of cirrhosis increased by 50.6% between 1998 and 2009. Although all causes of liver disease increased during this period, this trend was primarily attributed to rising levels of alcohol misuse and obesity. Cirrhosis generally results from chronic liver damage over many years. It is characterised by fibrosis and nodularity of the parenchyma, which interferes with the synthetic, metabolic and excretory functions of the liver...
November 2016: Practitioner
https://www.readbyqxmd.com/read/28967501/intra-individual-comparison-between-2-d-shear-wave-elastography-ge-system-and-virtual-touch-tissue-quantification-siemens-system-in-grading-liver-fibrosis
#14
Rosa M S Sigrist, Ahmed El Kaffas, R Brooke Jeffrey, Jarrett Rosenberg, Jürgen K Willmann
Ultrasound-based shear wave elastography (SWE) has recently gained substantial attention for non-invasive assessment of liver fibrosis. The purpose of this study was to perform an intra-individual comparison between 2-D shear wave elastography (2-D-SWE with a GE system) and Virtual Touch Tissue Quantification (VTTQ with a Siemens system) to assess whether these can be used interchangeably to grade fibrosis. Ninety-three patients (51 men, 42 women; mean age, 54 y) with liver disease of various etiologies (hepatitis B virus = 47, hepatitis C virus = 22; alcohol = 6, non-alcoholic steatohepatitis = 5, other = 13) were included...
September 26, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28966288/ultrasound-evaluation-of-liver-stiffness-accuracy-of-ultrasound-imaging-for-the-prediction-of-liver-cirrhosis-as-evaluated-using-a-liver-stiffness-measurement
#15
Momoe Endo, Yoko Soroida, Masaya Sato, Tamaki Kobayashi, Hiromi Hikita, Mamiko Sato, Hiroaki Gotoh, Tomomi Iwai, Shinji Sone, Tetsuo Sasano, Yuki Sumi, Kazuhiko Koike, Yutaka Yatomi, Hitoshi Ikeda
BACKGROUND AND AIMS: Because of the low penetration rate of transient elastography (TE) or its limitations in patients with obesity, narrow intercostal spaces, or ascites, the physical appearance of the liver as visualized using ultrasonography (US) is still thought to provide important information for the prediction of liver fibrosis. We examined the accuracy of various US signs when assessing the presence of liver cirrhosis, compared with TE. METHODS: We enrolled 189 patients who had undergone both conventional US and TE examinations...
2017: Journal of Medical and Dental Sciences
https://www.readbyqxmd.com/read/28965721/prospective-comparison-of-the-diagnostic-performance-of-magnetic-resonance-elastography-with-acoustic-radiation-force-impulse-elastography-for-pre-operative-staging-of-hepatic-fibrosis-in-patients-with-hepatocellular-carcinoma
#16
Chen-Te Chou, Ran-Chou Chen, Wen-Pei Wu, Ping-Yi Lin, Yao-Li Chen
The purpose of this study was to compare the diagnostic accuracy of magnetic resonance (MR) elastography with that of acoustic radiation force impulse (ARFI) elastography for pre-operative staging of hepatic fibrosis in patients with hepatocellular carcinoma. We prospectively enrolled 77 patients who were scheduled to undergo hepatectomy for hepatocellular carcinoma. Pre-operative MRE and ARFI elastography examinations were performed on the same day, and liver stiffness/velocity values were determined. Fibrosis stage and necro-inflammatory activity of resected specimens were determined histopathologically using the METAVIR scoring system...
September 28, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28964958/hepatitis-b-virus-reactivation-after-heart-transplant-incidence-and-clinical-impact
#17
Martina Vitrone, Domenico Iossa, Luca Rinaldi, Pia Clara Pafundi, Rosa Molaro, Antonio Parrella, Roberto Andini, Enrico Ragone, Ciro Maiello, Rosa Zampino, Emanuele Durante-Mangoni
BACKGROUND: Occult hepatitis B infection consists of persistence of HBV genomes in hepatocytes,absence of serum HBsAg, low/undetectable serum HBVDNA. Reactivation of HBV infection may occur during immunosuppression, but few data are available in heart transplant. OBJECTIVES: We followed-up heart recipients with or without markers of previous HBV infection,evaluating prevalence of HBV markers, incidence of HBV reactivation and its virological and clinical features...
September 23, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28953939/performance-of-transient-elastography-and-serum-fibrosis-biomarkers-for-non-invasive-evaluation-of-recurrent-fibrosis-after-liver-transplantation-a-meta-analysis
#18
Mamatha Bhat, Mahmood Tazari, Giada Sebastiani
Recurrent fibrosis after liver transplantation (LT) impacts on long-term graft and patient survival. We performed a meta-analysis to compare the accuracy of non-invasive methods to diagnose significant recurrent fibrosis (stage F2-F4) following LT. Studies comparing serum fibrosis biomarkers, namely AST-to-platelet ratio index (APRI), fibrosis score 4 (FIB-4), or transient elastography (TE) with liver biopsy in LT recipients were systematically identified through electronic databases. In the meta-analysis, we calculated the weighted pooled odds ratio and used a fixed effect model, as there was no significant heterogeneity between studies...
2017: PloS One
https://www.readbyqxmd.com/read/28953628/can-ultrasound-elastography-identify-mass-like-focal-fatty-change-ffc-from-liver-mass
#19
Tingting Qiu, Wenwu Ling, Jiawu Li, Qiang Lu, Changli Lu, Xiaomin Li, Cairong Zhu, Yan Luo
Focal fatty change (FFC) may mimic liver mass on conventional B-mode ultrasound. Clinical differentiation of mass-like FFC and liver mass is important due to different clinical interventions. Contrast-enhanced imaging (CEI) or biopsy is reliable for this differentiation, but is expensive and invasive. This study aimed to explore utilities of ultrasound elastography for this differentiation.This study enrolled 79 patients with focal liver lesions (FLLs), of which 26 were mass-like FFC confirmed by at least 2 CEI modalities...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28952003/uterine-fibroids-correlations-between-mri-appearance-and-stiffness-via-magnetic-resonance-elastography
#20
Danielle E Jondal, Jin Wang, Jun Chen, Krzysztof R Gorny, Joel Felmlee, Gina Hesly, Shannon Laughlin-Tommaso, Elizabeth A Stewart, Richard Ehman, David A Woodrum
RATIONALE AND OBJECTIVES: Magnetic resonance elastography has proven to be a valuable tool in the diagnosis of liver fibrosis, breast and cervical cancer, but its application in uterine fibroids requires further characterization. The aim of the present study was to examine the relationship between uterine fibroid stiffness by MRE and MR imaging characteristics. MATERIALS AND METHODS: An IRB-approved, HIPAA compliant review was performed of prospectively collected pelvic MRI and 2D-MRE data in patients with symptomatic uterine fibroids (N = 102)...
September 26, 2017: Abdominal Radiology
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