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Liver elastography

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https://www.readbyqxmd.com/read/28820411/-importance-of-shear-wave-elastography-of-livers-in-practically-healthy-pregnant-women
#1
E Sariyeva, S Salahova, N Bayramov
Pulse-wave elastography (SWE) that is one of the mostly used methods in the recent years holds important place in assessment of liver fibrosis. However there is no exact information on the results of liver elastography in healthy pregnant women in the world literature. The aim of the study was to investigate theSWE parameters of liver elastography in practically healthy pregnant women. The subject of the research was 50 practically healthy pregnant women within 18-45 years old (mean age 27.7±0.7). The pregnant women with genital and extragenital diseases were not included to the research...
July 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28811064/evaluation-of-non-alcoholic-fatty-liver-disease-using-acoustic-radiation-force-impulse-imaging-elastography-in-rat-models
#2
Yanrong Guo, Changfeng Dong, Haoming Lin, Xinyu Zhang, Huiying Wen, Yuanyuan Shen, Tianfu Wang, Siping Chen, Yingxia Liu, Xin Chen
The aim of this study is to evaluate the utility of acoustic radiation force impulse (ARFI) elastography for assessing hepatic fibrosis stage and non-alcoholic fatty liver disease (NAFLD) severity, as well as the relationship among hepatic histologic changes using shear wave velocity (SWV). Animal models with various degrees of NAFLD were established in 110 rats. The right liver lobe was processed and embedded in a fabricated gelatin solution (porcine skin). Liver mechanics were measured using SWV induced by acoustic radiation force...
August 12, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28807448/assessing-hepatic-fibrosis-using-2-d-shear-wave-elastography-in-patients-with-liver-tumors-a-prospective-single-center-study
#3
Zhongxi Huang, Wei Zheng, Yao-Jun Zhang, Li Xu, Jin-Bin Chen, Jian-Cong Chen, Min-Shan Chen, Zhongguo Zhou
The purpose of this study was to investigate the diagnostic performance of 2-D shear wave elastography (2-D-SWE) in evaluations of liver stiffness in patients with liver tumors before resection. A total of 121 consecutive patients with hepatocellular carcinoma (HCC) (n = 93), intra-hepatic cholangiocarcinoma (n = 6), mixed hepatocellular carcinoma and intra-hepatic cholangiocarcinoma (n = 6), liver metastases (n = 10) and benign tumors (n = 6) were prospectively enrolled in this study from June 2015 to March 2016...
August 11, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28804946/coefficient-of-variance-as-quality-criterion-for-evaluation-of-advanced-hepatic-fibrosis-using-2d-shear-wave-elastography
#4
Sanghyeok Lim, Seung Hyun Kim, Yongsoo Kim, Young Seo Cho, Tae Yeob Kim, Woo Kyoung Jeong, Joo Hyun Sohn
OBJECTIVES: To compare the diagnostic performance for advanced hepatic fibrosis measured by 2D shear-wave elastography (SWE), using either the coefficient of variance (CV) or the interquartile range divided by the median value (IQR/M) as quality criteria. METHODS: In this retrospective study, from January 2011 to December 2013, 96 patients, who underwent both liver stiffness measurement by 2D SWE and liver biopsy for hepatic fibrosis grading, were enrolled. The diagnostic performances of the CV and the IQR/M were analyzed using receiver operating characteristic curves with areas under the curves (AUCs) and were compared by Fisher's Z test, based on matching the cutoff points in an interactive dot diagram...
August 14, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28801939/assessment-of-advanced-hepatic-mr-elastography-methods-for-susceptibility-artifact-suppression-in-clinical-patients
#5
Jin Wang, Kevin J Glaser, Tianhui Zhang, Qungang Shan, Bingjun He, Jun Chen, Meng Yin, Bogdan Dzyubak, Jennifer L Kugel, Scott A Kruse, Roger C Grimm, Sudhakar K Venkatesh, Richard L Ehman
PURPOSE: To assess the success rate, image quality, and the ability to stage liver fibrosis of a standard 2D gradient-recalled echo (GRE) and four different spin-echo (SE) magnetic resonance elastography (MRE) sequences in patients with different liver iron concentrations. MATERIALS AND METHODS: A total of 332 patients who underwent 3T MRE examinations that included liver fat and iron quantification were enrolled, including 136 patients with all five MRE techniques...
August 11, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28800087/imaging-features-of-non-alcoholic-fatty-liver-disease-in-children-and-adolescents
#6
REVIEW
Michele Di Martino, Kameliya Koryukova, Mario Bezzi, Carlo Catalano
Non-invasive diagnosis and quantification of liver steatosis is important to overcome limits of liver biopsy, in order to follow up patients during their therapy and to establish a reference standard that can be used in clinical trials and longitudinal studies. Imaging offers several methods in this setting: ultrasound, which is the cheapest technique and easy to perform; magnetic resonance spectroscopy (MRS), which reflects the real content of triglycerides in a specific volume; and proton density fat fraction (PDFF) magnetic resonance, which is a simple method that reflects the distribution of the fat in the whole liver...
August 11, 2017: Children
https://www.readbyqxmd.com/read/28791501/skeletal-muscle-mass-to-visceral-fat-area-ratio-is-an-important-determinant-affecting-hepatic-conditions-of-non-alcoholic-fatty-liver-disease
#7
Takashi Shida, Kentaro Akiyama, Sechang Oh, Akemi Sawai, Tomonori Isobe, Yoshikazu Okamoto, Kazunori Ishige, Yuji Mizokami, Kenji Yamagata, Kojiro Onizawa, Hironori Tanaka, Hiroko Iijima, Junichi Shoda
BACKGROUND: Not only obesity but also sarcopenia is associated with NAFLD. The influence of altered body composition on the pathophysiology of NAFLD has not been fully elucidated. The aim of this study is to determine whether skeletal muscle mass to visceral fat area ratio (SV ratio) affects NAFLD pathophysiology. METHODS: A total of 472 subjects were enrolled. The association between SV ratio and NAFLD pathophysiological factors was assessed in a cross-sectional nature by stratification analysis...
August 8, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28790832/combination-of-sofosbuvir-and-daclatasvir-in-the-treatment-of-genotype-3-chronic-hepatitis-c-virus-infection-in-patients-on-maintenance-hemodialysis
#8
Jan Sperl, Sona Frankova, Miluse Kreidlova, Dusan Merta, Monika Tothova, Julius Spicak
Chronic hepatitis C virus infection (HCV) has a negative impact on the long-term survival of recipients of kidney transplants. HCV should be treated in hemodialyzed patients before their enlistment for kidney transplantation in order to avoid the reactivation of virus after transplantation. Direct-acting antivirals represent the current standard of care in hemodialyzed patients with HCV genotypes 1 and 4; in patients with genotypes 2 or 3, the optimal regimen is yet to be established. Sofosbuvir (SOF) and daclatasvir (DCV) represent an antiviral pangenotypic regimen with favorable pharmacokinetics in hemodialyzed patients...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28790227/evaluation-of-acoustic-radiation-force-impulse-arfi-for-fibrosis-staging-in-chronic-liver-diseases
#9
Rino Alvani Gani, Irsan Hasan, Andri Sanityoso, Cosmas Rinaldi A Lesmana, Juferdy Kurniawan, Chyntia Olivia Maurine Jasirwan, Kemal Fariz Kalista, Lutfie Lutfie
BACKGROUND: acoustic radiation force impulse (ARFI) is a new proposed noninvasive method for liver fibrosis staging. Integrated with B-mode ultrasonography, ARFI can be used to assess liver tissue condition. However its diagnostic accuracy is still being continuously evaluated. Also, there is lack of data regarding the utilization of ARFI in our population. This study aimed to evaluate the diagnostic value of ARFI as an alternative noninvasive modality for fibrosis staging in chronic hepatitis B and hepatitis C patients in our population...
April 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28790222/prevalence-and-profile-of-fibrosis-in-diabetic-patients-with-non-alcoholic-fatty-liver-disease-and-the-associated-factors
#10
Ignatius Bima Prasetya, Irsan Hasan, Wismandari Wisnu, Cleopas Martin Rumende
BACKGROUND: the risk of Non-Alcoholic Fatty Liver Disease (NAFLD) is increasing in patients with type-2 diabetes. Prevalence and factors related to the increased risk of NAFLD in diabetic patients in Indonesia has never been studied before. Data regarding the profile of fibrosis in the population has also been unknown. This study aimed to identify the difference on the profile of diabetic patients with and without NAFLD as well as the degree of fibrosis. METHODS: the study was conducted using a cross-sectional method in type-2 diabetic patients who were treated at the outpatient clinic of endocrinology and metabolic division in Cipto Mangunkusumo Hospital...
April 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28789631/efficacy-of-glutathione-for-the-treatment-of-nonalcoholic-fatty-liver-disease-an-open-label-single-arm-multicenter-pilot-study
#11
Yasushi Honda, Takaomi Kessoku, Yoshio Sumida, Takashi Kobayashi, Takayuki Kato, Yuji Ogawa, Wataru Tomeno, Kento Imajo, Koji Fujita, Masato Yoneda, Koshi Kataoka, Masataka Taguri, Takeharu Yamanaka, Yuya Seko, Saiyu Tanaka, Satoru Saito, Masafumi Ono, Satoshi Oeda, Yuichiro Eguchi, Wataru Aoi, Kenji Sato, Yoshito Itoh, Atsushi Nakajima
BACKGROUND: Glutathione plays crucial roles in the detoxification and antioxidant systems of cells and has been used to treat acute poisoning and chronic liver diseases by intravenous injection. This is a first study examining the therapeutic effects of oral administration of glutathione in patients with nonalcoholic fatty liver disease (NAFLD). METHODS: The study was an open label, single arm, multicenter, pilot trial. Thirty-four NAFLD patients diagnosed using ultrasonography were prospectively evaluated...
August 8, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28777887/role-of-2d-shear-wave-elastography-in-the-assessment-of-chronic-liver-diseases
#12
EDITORIAL
Siddharth Singh, Rohit Loomba
No abstract text is available yet for this article.
August 4, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28776387/the-baveno-vi-criteria-for-predicting-esophageal-varices-validation-in-real-life-practice
#13
Mafalda Sousa, Sónia Fernandes, Luísa Proença, Ana Paula Silva, Sónia Leite, Joana Silva, Ana Ponte, Jaime Rodrigues, João Carlos Silva, João Carvalho
BACKGROUND AND AIMS: According to the Baveno VI consensus, patients with liver stiffness < 20 kPa and a platelet count > 150,000 ul have very low risk of clinically significant varices and do not need a screening endoscopy. The aim of this study was to evaluate non-invasive methods as predictors of esophageal varices according to the Baveno VI recommendations, in real life clinical practice. METHODS: Retrospective evaluation of patients with chronic liver disease who underwent transient elastography between January 2013 and December 2015...
August 4, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28772340/inverse-relationship-between-hepatic-steatosis-and-hepatitis-b-viremia-results-of-a-large-case-control-study
#14
Rex Wh Hui, Wai-Kay Seto, Ka-Shing Cheung, Lung-Yi Mak, Kevin Sh Liu, James Fung, Danny Ka-Ho Wong, Ching-Lung Lai, Man-Fung Yuen
The potential interaction between chronic hepatitis B (CHB) and non-alcoholic fatty liver disease (NAFLD), two of the most prevalent liver diseases worldwide, has not been well-defined. We performed liver stiffness (LS) and controlled attenuation parameter (CAP) measurements using transient elastography in 1202 CHB patients. Of these, 601 steatotic patients were matched with non-steatotic controls in a 1:1 ratio by age, gender, nucleoside analogue treatment status, and treatment duration. Severe fibrosis was defined according to EASL-ALEH criteria, and steatosis defined as CAP ≥222 dB m(-1) ...
August 3, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28765706/non-invasive-assessment-of-liver-fibrosis-using-two-dimensional-shear-wave-elastography-in-patients-with-autoimmune-liver-diseases
#15
Jie Zeng, Ze-Ping Huang, Jian Zheng, Tao Wu, Rong-Qin Zheng
AIM: To determine the diagnostic accuracy of two-dimensional shear wave elastography (2D-SWE) for the non-invasive assessment of liver fibrosis in patients with autoimmune liver diseases (AILD) using liver biopsy as the reference standard. METHODS: Patients with AILD who underwent liver biopsy and 2D-SWE were consecutively enrolled. Receiver operating characteristic (ROC) curves were constructed to assess the overall accuracy and to identify optimal cut-off values...
July 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28765697/eight-week-ledipasvir-sofosbuvir-in-non-cirrhotic-treatment-na%C3%A3-ve-hepatitis-c-genotype-1-patients-with-hepatitis-c-virus-rna-6-million-single-center-real-world-effectiveness-and-safety
#16
Nyan L Latt, Beshoy T Yanny, Derenik Gharibian, Rita Gevorkyan, Amandeep K Sahota
AIM: To evaluate sustained viral response (SVR) of 8-wk ledipasvir/sofosbuvir therapy among non-cirrhotic, genotype-1 hepatitis C virus (HCV) patients with RNA < 6 million IU/mL. METHODS: We performed a retrospective cohort study to examine SVR rates, predictors of treatment failure and safety analysis of 8-wk ledipasvir/sofosbuvir (LDV/SOF) therapy among non-cirrhotic, genotype 1 HCV patients with viral load < 6 million IU/mL. Primary outcome was an achievement of SVR at 12 wk after treatment...
July 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28759632/significant-liver-fibrosis-assessed-using-liver-transient-elastography-is-independently-associated-with-low-bone-mineral-density-in-patients-with-non-alcoholic-fatty-liver-disease
#17
Gyuri Kim, Kwang Joon Kim, Yumie Rhee, Sung-Kil Lim
BACKGROUND: Metabolic bone disorders frequently occur in patients with chronic liver disease; however, the association between liver fibrosis and bone mineral density in patients with non-alcoholic fatty liver disease (NAFLD) is unclear. METHODS: This is a cross-sectional analysis of 231 asymptomatic subjects (160 women, 61.6 years old) from a university hospital setting, between February 2012 and December 2014. Bone mineral density (BMD) was measured at the lumbar spine, femur neck, and total hip using dual-energy X-ray absorptiometry (DXA)...
2017: PloS One
https://www.readbyqxmd.com/read/28752925/management-of-portal-hypertension-before-and-after-liver-transplantation
#18
L W Unger, G Berlakovich, M Trauner, T Reiberger
Orthotopic liver transplantation (OLT) represents a curative treatment option for end-stage liver disease (ESLD). While epidemiology of ESLD has recently changed due the rising prevalence of non-alcoholic fatty liver disease (NAFLD) and decreased burden of hepatitis C virus (HCV) infections due to highly-effective antiviral regimens, the management of portal hypertension (PHT) remains a clinical challenge in the pre- and post-OLT setting. The measurement of hepatic venous pressure gradient (HVPG) represents the most reliable, but invasive tool for assessment of the severity of PHT...
July 28, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28750503/protein-and-vitamin-b6-intake-are-associated-with-liver-steatosis-assessed-by-transient-elastography-especially-in-obese-individuals
#19
Yvelise Ferro, Ilaria Carè, Elisa Mazza, Francesco Provenzano, Carmela Colica, Carlo Torti, Stefano Romeo, Arturo Pujia, Tiziana Montalcini
Background/Aims: Although the detrimental effects of several dietary components on the promotion of nonalcoholic fatty liver disease are well known, no studies have assessed the role of dietary vitamin B6. Moreover, studies on the associations between dietary components or body composition indices and liver steatosis assessed by transient elastography are rare. Our aim was to identify the nutritional factors and anthropometric parameters associated with liver steatosis. Methods: In this cross-sectional study, we enrolled 168 individuals (35% obese) who underwent a liver steatosis assessment by Controlled Attenuation Parameter measurement and nutritional assessment...
July 28, 2017: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/28735336/acoustic-radiation-force-impulse-arfi-elastography-and-serological-markers-in-assessment-of-liver-fibrosis-and-free-portal-pressure-in-patients-with-hepatitis-b
#20
Jun Li, Jie Yu, Xin-Yu Peng, Ting-Ting Du, Jia-Jia Wang, Jin Tong, Gui-Lin Lu, Xiang-Wei Wu
BACKGROUND The aim of this study was to investigate the feasibility of using acoustic radiation force impulse (ARFI) elastography, AST-to-platelet ratio index (APRI), and FIB-4 in assessing liver fibrosis and free portal pressure in patients with hepatitis B. MATERIAL AND METHODS We enrolled 126 patients with hepatitis B who underwent liver surgery at the General Surgery Department of the First Affiliated Hospital of Shihezi University Medical School from February 2013 to August 2015. Preoperatively, shear wave velocity (SWV) of the liver was measured with the Siemens S2000 ultrasound system to reflect liver stiffness...
July 23, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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