keyword
https://read.qxmd.com/read/38544762/evaluation-of-hepatic-steatosis-and-fibrosis-using-transient-elastography-in-patients-with-obstructive-sleep-apnea
#1
JOURNAL ARTICLE
Ashwin Parchani, Ravi Gupta, Ravi Kant, Lokesh K Saini, Rohit Gupta
OBJECTIVES: Obstructive sleep apnea (OSA) is an independent risk factor for non-alcoholic fatty liver disease. This study was planned to assess proportion of patients with OSA that have hepatic steatosis and fibrosis, as measured by transient elastography, to explore variables influencing their development and to find out the polysomnography parameters that predict the need for transient elastography screening in OSA. METHODS: Consecutive participants having polysomnography proven OSA were included in the study after screening for eligibility criteria...
2024: Journal of Clinical and Experimental Hepatology
https://read.qxmd.com/read/38543737/effects-of-hcv-clearance-with-direct-acting-antivirals-daas-on-liver-stiffness-liver-fibrosis-stage-and-metabolic-cellular-parameters
#2
JOURNAL ARTICLE
Joana Ferreira, Manuel Bicho, Fátima Serejo
INTRODUCTION: Chronic hepatitis C (CHC) is a clinical and pathological syndrome with various causes and is characterized by varying degrees of hepatocellular necrosis and inflammation. It is a significant cause of liver transplantation and liver-related death worldwide. The hepatic manifestations of CHC are typically characterized by slowly progressing liver fibrosis, which is a non-specific and often disproportionate response to tissue damage. A large majority of HCV patients have extrahepatic manifestations with varying degrees of severity...
February 27, 2024: Viruses
https://read.qxmd.com/read/38542785/higher-level-steatosis-is-associated-with-a-greater-decrease-in-metabolic-dysfunction-associated-steatoic-liver-disease-after-eight-weeks-of-a-very-low-calorie-ketogenic-diet-vlckd-in-subjects-affected-by-overweight-and-obesity
#3
JOURNAL ARTICLE
Annamaria Sila, Sara De Nucci, Caterina Bonfiglio, Vincenza Di Stasi, Nicole Cerabino, Martina Di Chito, Roberta Rinaldi, Paola Cantalice, Endrit Shahini, Vito Giannuzzi, Pasqua Letizia Pesole, Sergio Coletta, Nicoletta Maria Tutino, Giuseppina Piazzolla, Raffaele Cozzolongo, Gianluigi Giannelli, Giovanni De Pergola
The most common form of chronic liver disease, recently defined as MASLD, is strongly linked to obesity and metabolic syndrome. Lifestyle changes are part of MASLD prevention. The very low-calorie ketogenic diet (VLCKD) is a useful option for treating MASLD and reducing liver steatosis in patients with obesity. We assessed whether a greater degree of steatosis could have a positive or negative impact on how well 8 weeks of using the VLCKD improve steatosis and fibrosis in a patient population of overweight and obese individuals...
March 18, 2024: Nutrients
https://read.qxmd.com/read/38541992/does-portal-hypertension-increase-the-risk-of-helicobacter-pylori-infection-and-pre-malignant-gastric-lesions
#4
JOURNAL ARTICLE
Rui Gaspar, Pedro Cardoso, Tiago Ribeiro, Marco Silva, Guilherme Macedo
Background and Aims: The presence of portal hypertension in cirrhotic patients is a major prognostic factor associated with the development of severe complications and increased mortality. The gold standard for diagnosing portal hypertension is the hepatic venous pressure gradient. More recently, spleen stiffness has emerged as a new and non-invasive diagnostic tool, and has already been included in the last Baveno VII guidelines. The exact prevalence of Helicobacter pylori infection, pre-malignant lesions and their relation to portal hypertension have never been described...
March 19, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541667/liver-stiffness-values-to-predict-occurrence-and-recurrence-of-hepatocellular-carcinoma
#5
REVIEW
Cristina Stasi, Stefano Brillanti
Globally, liver cancer is the third most frequent etiology of cancer death, with the rates of occurrence of both new cases and mortality estimated to increase. Given the availability of multiple treatments, interdisciplinary management of the patient is crucial. Moreover, the diagnostic assessment of patients with severe liver fibrosis is essential for the staging of HCC and liver cirrhosis and early diagnosis of HCC. In this context, non-invasive evaluation plays a critical role in identifying prognostic factors of clinical application for the surveillance of the occurrence or recurrence of HCC...
March 6, 2024: Life
https://read.qxmd.com/read/38539276/relationship-between-albumin-corrected-anion-gap-and-non-alcoholic-fatty-liver-disease-varied-in-different-waist-circumference-groups-a-cross-sectional-study
#6
JOURNAL ARTICLE
Ye Lu, Ya-Zhen Zhan, Wan Li, Shu-Li Liao
OBJECTIVES: To investigate the association of albumin-corrected anion gap (ACAG) with non-alcoholic fatty liver disease (NAFLD) and clinically significant fibrosis (CSF) defined by vibration-controlled transient elastography measurements. METHODS: This cross-sectional study including 4531 participants was conducted using the data from the NHANES database of cycles 2017-2018. The outcomes were set as NAFLD vs. non-NAFLD and NAFLD with CSF vs. NAFLD without CSF. The generalized additive model and restricted cubic spline analyses were used to assess the nonlinear relationship...
March 27, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38537184/multiparametric-ultrasound-evaluation-of-liver-fibrosis-steatosis-and-viscosity-in-patients-with-chronic-liver-disease
#7
JOURNAL ARTICLE
Iulia Minciuna, Madalina Taru, Andreea Fodor, Oana Nicoara Farcau, Petra Fischer, Corina Radu, Monica Lupsor-Platon, Horia Stefanescu, Bogdan Procopet
AIMS: This study assessed the effectiveness of three ultrasound-based techniques (2D-SWE.PLUS, Att.PLUS, Vi.PLUS) for non-invasive evaluation of liver fibrosis, steatosis, and inflammation in chronic liver disease (CLD) patients.Materials and methods: Involving 209 consecutive compensated CLD patients, the study compared these ultrasound methods from Aixplorerwith standard Vibration-controlled Transient Elastography (VCTE) and Controlled Attenuation Parameter (CAP) from Fibroscan, alongside non-invasive serological markers...
February 7, 2024: Medical Ultrasonography
https://read.qxmd.com/read/38535025/comparison-of-transient-elastography-and-point-shear-wave-elastography-for-analysis-of-liver-stiffness-a-prospective-study
#8
JOURNAL ARTICLE
Giuseppe Losurdo, Ilaria Ditonno, Domenico Novielli, Francesca Celiberto, Andrea Iannone, Antonino Castellaneta, Paola Dell'Aquila, Nunzio Ranaldo, Maria Rendina, Michele Barone, Enzo Ierardi, Alfredo Di Leo
Liver stiffness measurement (LSM) by Fibroscan is the most used non-invasive method to assess liver fibrosis. Recently, point-shear wave elastography (pSWE) has been introduced as a simple alternative non-invasive test. Therefore, we aimed to compare the results of these two techniques. One hundred and eighty-four consecutive patients attending our outpatient ultrasound clinic were recruited. LSM was performed by both Fibroscan and pSWE. Statistical analysis was conducted by Spearman's test for correlation and linear regression...
March 12, 2024: Diagnostics
https://read.qxmd.com/read/38532896/investigating-the-impact-of-elevated-urinary-trace-elements-on-non-alcoholic-fatty-liver-disease-using-vibration-controlled-transient-elastography
#9
JOURNAL ARTICLE
Chenxiao Wang, Xin Shang, Yu Fu, Panpan Guo, Ping Wang, Shuxun Yan
INTRODUCTION: Non-alcoholic fatty liver disease (NAFLD) is a global public health concern. However, limited data are available on urinary trace elements and NAFLD caused by various exposure factors. This study aimed to investigate the relationship between the presence of 16 trace elements in urine and NAFLD using data from the National Health and Nutrition Examination Survey (NHANES). METHODS: By utilizing the NHANES data from 2017 to 2018, 1613 participants who fulfilled the research criteria were identified from the initial pool of 2979 participants with available urine trace element detection data...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38532435/liver-stiffness-and-associated-risk-factors-among-people-with-a-history-of-injecting-drugs-a-prospective-cohort-study
#10
JOURNAL ARTICLE
Karl Trygve Druckrey-Fiskaaen, Jørn Henrik Vold, Tesfaye Madebo, Håvard Midgard, Olav Dalgard, Rafael Alexander Leiva, Lars T Fadnes
BACKGROUND: Persons with opioid use disorders (OUD) and persons with substance use disorders (SUD) who inject substances have a reduced life expectancy of up to 25 years compared with the general population. Chronic liver diseases are a substantial cause of this. Screening strategies based on liver stiffness measurements (LSM) may facilitate early detection, timely intervention, and treatment of liver disease. This study aims to investigate the extent of chronic liver disease measured with transient elastography and the association between LSM and various risk factors, including substance use patterns, hepatitis C virus (HCV) infection, alcohol use, body mass index, age, type 2 diabetes mellitus, and high-density lipoprotein (HDL) cholesterol among people with OUD or with SUD who inject substances...
March 26, 2024: Substance Abuse Treatment, Prevention, and Policy
https://read.qxmd.com/read/38530543/viscoelastic-parameters-derived-from-multifrequency-mr-elastography-for-depicting-hepatic-fibrosis-and-inflammation-in-chronic-viral-hepatitis
#11
JOURNAL ARTICLE
Yikun Wang, Jiahao Zhou, Huimin Lin, Huafeng Wang, Ingolf Sack, Jing Guo, Fuhua Yan, Ruokun Li
OBJECTIVES: The capability of MR elastography (MRE) to differentiate fibrosis and inflammation, and to provide precise diagnoses is crucial, whereas the coexistence of fibrosis and inflammation may obscure the diagnostic accuracy. METHODS: In this retrospective study, from June 2020 to December 2022, chronic viral hepatitis patients who underwent multifrequency MRE (mMRE) were included in, and further divided into, training and validation cohorts. The hepatic viscoelastic parameters [shear wave speed (c) and loss angle (φ) of the complex shear modulus] were obtained from mMRE...
March 26, 2024: Insights Into Imaging
https://read.qxmd.com/read/38527437/liver-stiffness-determined-by-transient-elastography-is-a-simple-and-highly-accurate-predictor-for-presence-of-liver-cirrhosis-in-clinical-routine
#12
JOURNAL ARTICLE
Peter Lemmer, Lydia Christina Rohr, Marie Henning, Kerem Bulut, Paul Manka, Ali Canbay, Jan-Peter Sowa
INTRODUCTION: Early detection of patients with advanced chronic liver disease is critical for prevention of complications and inclusion in surveillance programs for hepatocellular carcinoma. In daily clinical care, it remains challenging to differentiate early cirrhosis from lower fibrosis grades without performing a liver biopsy. Aim of the present study was to assess performance of different non-invasive detection tools to differentiate cirrhosis from lower fibrosis grades. METHODS: Data of 116 patients (51 male, 65 female) with chronic liver disease of various origin undergoing liver biopsy was analysed...
March 25, 2024: Digestive Diseases
https://read.qxmd.com/read/38526946/metabolic-dysfunction-associated-steatotic-liver-disease-related-hepatic-fibrosis-increases-risk-of-insulin-resistance-type-2-diabetes-and-chronic-kidney-disease
#13
JOURNAL ARTICLE
Weijing Zhang, Wen Jing Song, Weiyu Chen, Zoucheng Pan, Jiawei Zhang, Li Fan, Jie Li
Metabolic dysfunction-associated steatotic liver disease (MASLD) (previously called nonalcoholic fatty liver disease, NAFLD) is associated with cardiometabolic risk factors and chronic kidney disease (CKD). However, evidence is lacking regarding whether the severity of fibrosis is affected by these risk factors and diseases and to what degree. We aimed to determine the correlation between these factors and vibration-controlled transient elastography-determined liver stiffness measurements (LSMs) and controlled attenuation parameter (CAP) values in a sample of the US population...
March 22, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38526936/a-comparative-study-of-three-ultrasound-techniques-for-liver-fibrosis-staging
#14
JOURNAL ARTICLE
Qianqian Shen, Jiaqi Zhang, Shangjie Yang, Liping Liu
The aim of this study is to assess the agreement and performance of visual transient elastography (ViTE), sound touch elastography (STE), and sound touch quantification (STQ) for liver fibrosis staging using transient elastography (TE) as a standard. We finally enrolled 252 subjects with chronic liver disease (CLD) who underwent ViTE, STE, STQ, and TE examinations simultaneously in our hospital from October 2022 to July 2023. We evaluated the correlation and agreement between various technologies. And also evaluated the performances and optimal cutoffs of ViTE, STE, and STQ ...
March 19, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38521854/association-of-the-fat-mass-index-with-hepatic-steatosis-and-fibrosis-evidence-from-nhanes-2017-2018
#15
JOURNAL ARTICLE
Lihe Liu, Jiaxi Lin, Minyue Yin, Lu Liu, Jingwen Gao, Xiaolin Liu, Jinzhou Zhu, Airong Wu
Limited population-based studies discuss the association between fat mass index (FMI) and the risk of liver diseases. This investigation utilized data from the National Health and Nutrition Examination Survey (NHANES) to examine the linkage between the FMI and liver conditions, specifically steatosis and fibrosis. The study leveraged data from NHANES's 2017-2018 cross-sectional study, employing an oversampling technique to deal with sample imbalance. Hepatic steatosis and fibrosis were identified by vibration-controlled transient elastography...
March 23, 2024: Scientific Reports
https://read.qxmd.com/read/38521170/post-treatment-lsm-rather-than-change-during-treatment-predicts-decompensation-in-patients-with-cacld-after-hcv-cure
#16
JOURNAL ARTICLE
Georg Semmler, Sonia Alonso López, Monica Pons, Sabela Lens, Elton Dajti, Marie Griemsmann, Alberto Zanetto, Lukas Burghart, Stefanie Hametner-Schreil, Lukas Hartl, Marisa Manzano, Sergio Rodriguez-Tajes, Paola Zanaga, Michael Schwarz, María Luisa Gutierrez, Mathias Jachs, Anna Pocurull, Benjamín Polo, Dominik Ecker, Beatriz Mateos, Sonia Izquierdo, Yolanda Real, Adriana Ahumada, David Josef Maria Bauer, Jim Benjamin Mauz, Michelle Casanova-Cabral, Michael Gschwantler, Francesco Paolo Russo, Francesco Azzaroli, Benjamin Maasoumy, Thomas Reiberger, Xavier Forns, Joan Genesca, Rafael Bañares, Mattias Mandorfer
BACKGROUND & AIMS: Baveno VII has defined a clinically significant (i.e., prognostically meaningful) liver stiffness measurement (LSM)-decrease in cACLD by ≥20% associated with a final LSM<20 kPa, or any decrease to <10 kPa. However, these rules have not yet been validated against direct clinical endpoints. METHODS: We retrospectively analysed cACLD patients (LSM≥10 kPa) with paired liver stiffness measurement (LSM) before (BL) and after (FU) HCV-cure by interferon-free therapies from 15 European centers...
March 21, 2024: Journal of Hepatology
https://read.qxmd.com/read/38518655/predictors-of-liver-disease-progression-in-people-living-with-hiv-hbv-co-infection-on-antiretroviral-therapy
#17
JOURNAL ARTICLE
Kasha P Singh, Anchalee Avihingsanon, Jennifer M Zerbato, Wei Zhao, Sabine Braat, Surekha Tennakoon, Ajantha Rhodes, Gail V Matthews, Christopher K Fairley, Joe Sasadeusz, Megan Crane, Jennifer Audsley, Sharon R Lewin
BACKGROUND: In people living with HIV-HBV, liver fibrosis progression can occur even with suppressive antiretroviral therapy (ART). We investigated the relationship between liver fibrosis and biomarkers of inflammation, apoptosis, and microbial translocation. METHODS: In this observational cohort study adults living with HIV-HBV already on effective ART were recruited in Australia and Thailand and followed for 3 years including 6 monthly clinical review and blood tests and annual transient elastography...
March 21, 2024: EBioMedicine
https://read.qxmd.com/read/38517204/velacur-ace-outperforms-fibroscan-cap-for-diagnosis-of-masld
#18
JOURNAL ARTICLE
Rohit Loomba, Alnoor Ramji, Tarek Hassanein, Eric M Yoshida, Emily Pang, Caitlin Schneider, Michael P Curry, Nezam H Afdhal
BACKGROUND: As the prevalence of metabolic dysfunction-associated steatotic liver disease increases, it is imperative to have noninvasive alternatives to liver biopsy. Velacur offers a non-invasive, point-of-care ultrasound-based method for the assessment of liver stiffness and attenuation. The aim of this study was to perform a head-to-head comparison of liver stiffness and liver fat determined by Velacur and FibroScan using MRI-based measurements as the reference standard. METHODS: This prospective cross-sectional study included 164 adult participants with well-characterized metabolic dysfunction-associated steatotic liver disease...
April 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38514588/sleep-factors-were-associated-with-a-higher-risk-of-mafld-and-significant-fibrosis
#19
JOURNAL ARTICLE
Yaxin Li, Shiyun Tan
PURPOSE: The relationships of sleep factors separately and jointly with metabolic associated fatty liver disease (MAFLD) and significant fibrosis remain unclear. We intended to explore the relationships in the United States. METHODS: This cross-sectional study included 4477 individuals from the National Health and Nutrition Examination Survey from 2017 to 2018. Information regarding each sleep factor (sleep duration, trouble sleeping, snoring, excessive daytime sleep, and sleep apnea symptoms) was obtained through questionnaires...
March 22, 2024: Sleep & Breathing
https://read.qxmd.com/read/38514508/associations-of-urinary-nickel-with-nafld-and-liver-fibrosis-in-the-usa-a-nationwide-cross%C3%A2-sectional-study
#20
JOURNAL ARTICLE
Kening Zhang, Chunxiao Yang, Xue Zhao, Yuanyuan Wang, Zhuo Gu, Ruiming Yang, Haiyan Ding, Shuangshuang Li, Jian Qin, Xia Chu
Despite the robust correlation between metabolic disorders and heavy metals, there has been limited research on the associations between nickel levels and non-alcoholic fatty liver disease (NAFLD) as well as liver fibrosis. This study aimed to examine the associations among urinary nickel, NAFLD, and liver fibrosis. The data utilized in this study were obtained from the National Health and Nutrition Examination Survey 2017-2020. A comprehensive screening process was conducted, resulting in the inclusion of a total of 3169 American adults in the analysis...
March 22, 2024: Biological Trace Element Research
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