Read by QxMD icon Read


Thomas V Kodankandath, Paul Wright, Paul M Power, Marcella De Geronimo, Richard B Libman, Thomas Kwiatkowski, Jeffrey M Katz
BACKGROUND AND OBJECTIVE: The transfer of acute ischemic stroke (AIS) patients to a comprehensive stroke center (CSC) must be rapid. Delays pose an obstacle to time-sensitive stroke treatments and, therefore, increase the likelihood of exclusion from endovascular stroke therapy. This study aims to evaluate the impact of the Stroke Rescue Program, with its goal of minimizing interfacility transfer delays and increasing the number of transport times completed within 60 minutes. METHODS: The Stroke Rescue Program was initiated to facilitate the rapid transfer of AIS patients from regional primary stroke centers (PSCs) to the network's CSC...
October 12, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Michal R Janik, Maciej Walędziak, Jakub Brągoszewski, Andrzej Kwiatkowski, Krzysztof Paśnik
INTRODUCTION: Laparoscopic sleeve gastrectomy (LSG) is one of the most frequently performed bariatric procedures. Hemorrhagic complications (HC) after surgery are common and require surgical revision. Accurate estimation of the risk of postoperative HC can improve surgical decision-making process and minimize the risk of reoperation. The aim of the present study was to develop a predictive model for HC after LSG. MATERIAL AND METHODS: The retrospective analysis of 522 patients after primary LSG was performed...
October 11, 2016: Obesity Surgery
Mirosław Kwiatkowski, Vanessa Fierro, Alain Celzard
This paper presents the results of the application of the advanced LBET and QSDFT methods compared to the BET and DR approach to the comprehensive analysis of the porous structure of activated carbons obtained by chemical activation of demineralised Kraft lignin with potassium and sodium hydroxides. Based on the analysis of nitrogen adsorption isotherms, the influence of the preparation process conditions on the porous structure formation was investigated. Particularly, the impact of the type of activating agent, the activation temperature, the hydroxide to lignin mass ratio, and the flow rate of inert gas on the porous structure formation was assessed...
October 4, 2016: Journal of Colloid and Interface Science
Robert J Adams, Dan T Lackland, Lynette Brown, David Brown, Jenifer Voeks, Heather J Fullerton, Julie Kanter, Janet L Kwiatkowski
In children with Sickle Cell Disease, the combination of risk stratification with Transcranial Doppler Ultrasound (TCD) and selective chronic red cell transfusion (CRCT-the STOP Protocol) is one of the most effective stroke prevention strategies in medicine. How fully it is being implemented is unclear. Nineteen of 26 sites that conducted the two pivotal clinical trials (STOP and STOP II) participated in Post STOP, a comprehensive medical records review assessing protocol implementation in the 10-15 years since the trials ended...
September 13, 2016: American Journal of Hematology
Jennifer Hamm, Nisha Rathore, Pearlene Lee, Zachary LeBlanc, Jeffrey Lebensburger, Emily Riehm Meier, Janet L Kwiatkowski
BACKGROUND: Patients with sickle cell disease (SCD) may experience many complications of the central nervous system (CNS) including stroke, silent cerebral infarcts, and neuropsychological deficits. Cranial epidural hematoma is a rare but potentially serious complication. PROCEDURE: Case series of cranial epidural hematomas in children with SCD from three different institutions is considered, along with a literature review of cranial epidural hematomas in this population...
September 13, 2016: Pediatric Blood & Cancer
E Steve Roach, David J Kwiatkowski
No abstract text is available yet for this article.
September 6, 2016: Lancet
Carol F Kwiatkowski, Ashley L Bolden, Richard A Liroff, Johanna R Rochester, John G Vandenbergh
No abstract text is available yet for this article.
September 1, 2016: Environmental Health Perspectives
Tinghu Zhang, Nicholas Kwiatkowski, Calla M Olson, Sarah E Dixon-Clarke, Brian J Abraham, Ann K Greifenberg, Scott B Ficarro, Jonathan M Elkins, Yanke Liang, Nancy M Hannett, Theresa Manz, Mingfeng Hao, Bartlomiej Bartkowiak, Arno L Greenleaf, Jarrod A Marto, Matthias Geyer, Alex N Bullock, Richard A Young, Nathanael S Gray
Cyclin-dependent kinases 12 and 13 (CDK12 and CDK13) play critical roles in the regulation of gene transcription. However, the absence of CDK12 and CDK13 inhibitors has hindered the ability to investigate the consequences of their inhibition in healthy cells and cancer cells. Here we describe the rational design of a first-in-class CDK12 and CDK13 covalent inhibitor, THZ531. Co-crystallization of THZ531 with CDK12-cyclin K indicates that THZ531 irreversibly targets a cysteine located outside the kinase domain...
October 2016: Nature Chemical Biology
Rafał Rzepka, Barbara Dołęgowska, Aleksandra Rajewska, Daria Sałata, Marta Budkowska, Sebastian Kwiatkowski, Andrzej Torbé
Preterm birth remains the most prevalent cause of neonatal morbidity. This study aimed to evaluate the diagnostic value of SDF-1α, resistin, secretory RAGE (sRAGE), and endogenous secretory RAGE (esRAGE) in preterm labor. A total of 211 pregnant women participated in the study. Group A contained 72 women between 22 and 36 weeks of gestation, with premature labor, who finally had preterm birth. Group B contained 66 women in labor between 37 and 41 weeks of gestation. Women in group A had lower SDF-1α and sRAGE levels than those in group B...
2016: BioMed Research International
Agnieszka Sliwinska, Dominik Kwiatkowski, Piotr Czarny, Monika Toma, Paulina Wigner, Jozef Drzewoski, Krystyna Fabianowska-Majewska, Janusz Szemraj, Michael Maes, Piotr Galecki, Tomasz Sliwinski
Evidence indicates that oxidative stress contributes to neuronal cell death in Alzheimer's disease (AD). Increased oxidative DNA damage l, as measured with 8-oxoguanine (8-oxoG), and reduced capacity of proteins responsible for removing of DNA damage, including 8-oxoguanine DNA glycosylase 1 (OGG1), were detected in brains of AD patients. In the present study we assessed peripheral blood biomarkers of oxidative DNA damage, i.e. 8- oxoG and OGG1, in AD diagnosis, by comparing their levels between the patients and the controls...
September 15, 2016: Journal of the Neurological Sciences
Alistair Miles, Zamin Iqbal, Paul Vauterin, Richard Pearson, Susana Campino, Michel Theron, Kelda Gould, Daniel Mead, Eleanor Drury, John O'Brien, Valentin Ruano Rubio, Bronwyn MacInnis, Jonathan Mwangi, Upeka Samarakoon, Lisa Ranford-Cartwright, Michael Ferdig, Karen Hayton, Xin-Zhuan Su, Thomas Wellems, Julian Rayner, Gil McVean, Dominic Kwiatkowski
The malaria parasite Plasmodium falciparum has a great capacity for evolutionary adaptation to evade host immunity and develop drug resistance. Current understanding of parasite evolution is impeded by the fact that a large fraction of the genome is either highly repetitive or highly variable and thus difficult to analyze using short-read sequencing technologies. Here, we describe a resource of deep sequencing data on parents and progeny from genetic crosses, which has enabled us to perform the first genome-wide, integrated analysis of SNP, indel and complex polymorphisms, using Mendelian error rates as an indicator of genotypic accuracy...
September 2016: Genome Research
Pedro S Gomes, Amir Zomorodian, Lech Kwiatkowski, Rafal Lutze, Alicja Balkowiec, Bruno Colaço, Vitor Pinheiro, João C S Fernandes, Maria F Montemor, Maria H Fernandes
Magnesium alloys are regarded as potential biodegradable load-bearing biomaterials for orthopedic applications due to their physico-chemical and biomechanical properties. However, their clinical applicability is restricted by their high degradation rate, which limits the physiological reconstruction of the neighbouring tissues. In this work, a multifunctional coating architecture was developed on an AZ31 alloy by conjoining an anodization process with the deposition of a polymeric-based layer consisting of polyether imine reinforced with hydroxyapatite nanoparticles, aiming at improved control of the corrosion activity and biological performance of the Mg substrate...
2016: Biomedical Materials
M Bieniasz, A Chmura, M Kwapisz, M Czerwińska, R Kieszek, P Domagała, M Wszoła, M Serwańska-Świętek, B Górnicka, M Durlik, L Pączek, A Kwiatkowski
BACKGROUND: Malignancies will be a leading cause of mortality in renal transplant recipients in the next 20 years. Renal cell cancer (RCC) is the most common urologic cancer in kidney transplant recipients. The risk of RCC development in kidney transplant recipients is 15-100 times higher than in the general population. The purpose of the current retrospective study was to assess the frequency of nephrectomies performed because of renal tumors in the native kidneys in kidney transplant recipients in the Department of General and Transplantation Surgery at the Medical University of Warsaw between 2010 and 2014 year; the identification of kidney recipients diagnosed with RCC; and epidemiologic, clinical, and histopathological aspects associated with RCC...
June 2016: Transplantation Proceedings
A Perkowska-Ptasińska, D Dęborska-Materkowska, M Serwańska-Świętek, M Wszoła, A Kwiatkowski, M Durlik
BACKGROUND: We report 2 cases of polyomavirus-associated nephropathy (PyVAN) emerging within the initial 8 posttransplant weeks. These cases were characterized by intraepithelial BK virus replication without typical nuclear inclusions in epithelial cells. METHODS AND RESULTS: A 70-year-old male recipient of a cadaveric kidney transplant had experienced unsatisfying graft function since the time of transplantation (Tx). One month after Tx, results of a graft biopsy revealed mild tubulointerstitial inflammation...
June 2016: Transplantation Proceedings
K Majchrzak, E Mierzwinska-Nastalska, A Chmura, A Kwiatkowski, L Paczek, G Mlynarczyk, K Szymanek-Majchrzak
BACKGROUND: Biofilm occurring on removable prostheses is a reservoir of bacterial flora, consisting of both physiological and pathogenic multidrug-resistant microorganisms. Patients undergoing dialysis and organ transplantation are particularly prone to bacterial infections, which can have its source in denture plaque. This study was a comparison of the composition of staphylococcal flora within the surface of the pharyngeal mucous membrane as well as denture plaque in kidney transplant recipients...
June 2016: Transplantation Proceedings
J Gozdowska, M Czerwińska, Ł Chabros, G Młynarczyk, A Kwiatkowski, A Chmura, M Durlik
INTRODUCTION: The aim of this study was to investigate risk factors for urinary tract infections (UTI), the causative organisms of UTI and also their management and treatment. In addition, we evaluated the effects of UTI on renal graft function. METHODS: This analysis included 107 kidney transplant recipients (64% women) with a diagnosis of UTIs confirmed by positive results on urine culture. Type of pathogens, sensitivity to drugs, risk factors for infection, incidence of urosepsis, hospitalization period, treatment methods, and recurrence rates were analyzed...
June 2016: Transplantation Proceedings
J Gozdowska, E Jędrych, A Chabior, R Kieszek, A Kwiatkowski, A Chmura, M Durlik
BACKGROUND: Cardiovascular (CV) complications are the major cause of death in kidney transplant (KT) patients. METHODS: During a 3-year follow-up, 112 KT recipients, from living (LD KTRs; n = 54), and deceased (DD KTRs; n = 58) donors, were assessed for 10-year risk of fatal CV events with the use of the Heartscore tool ( In post-KT months 6, 12, and 36, current and optimum (target) CV risks (CVRs) were estimated. RESULTS: Current risk was lower in the LD KTRs and remained stable...
June 2016: Transplantation Proceedings
J Pazik, Z Lewandowski, M Oldak, D Oziębło, A Perkowska Ptasinska, A Sadowska, E Nowacka-Cieciura, M Nowaczyk, J Malejczyk, A Kwiatkowski, M Durlik
Allelic variants of the MYH9 gene, encoding myosin nonmuscle heavy chain type IIA, have been shown to correlate with diminished glomerular filtration rates and end-stage kidney disease in individuals of Caucasian ancestry. Myosin nonmuscle heavy chain type IIA is expressed during development as well as in injured vessels and kidney structures. We hypothesized that MYH9 risk variants may correlate with kidney artery injury and dysfunctional healing, such as transplant renal artery stenosis (TRAS). Our study aimed at evaluating the association of MYH9 risk allelic variants (rs4821480, rs4821481, rs3752462, rs11089788, rs136211, rs5756168, rs2032487, and rs2239784) with TRAS, defined as >50% renal artery lumen reduction...
June 2016: Transplantation Proceedings
J Gozdowska, M Zatorski, P Torchalla, Ł Białek, A Bojanowska, A Tomaszek, M Serwańska-Świętek, R Kieszek, A Kwiatkowski, A Chmura, M Durlik
INTRODUCTION: Health benefits of a living-donor kidney transplantation are numerous and well known. There is, however, a dearth of knowledge on postoperative quality of life among the living-donor (LD) compared to deceased-donor (DD) transplant recipients. MATERIALS AND METHODS: The study involved 89 patients after renal transplantation: 48 from LDs and 41 from DDs. Interview data indirectly indicated the patients' health, whereas physiological parameters directly pinpointed the patients' health and the graft function...
June 2016: Transplantation Proceedings
A Jozwik, P Domagala, R Kieszek, M Wszola, M Serwanska-Swietek, E Karpeta, L Gorski, M Bieniasz, M Jonas, A Berman, L Paczek, M Durlik, A Chmura, A Kwiatkowski
AIM: A major problem for the transplant society is a shortage of organs for transplantation compared with the number of patients on the waiting list. This study aimed to assess the results of the transplantation of kidneys procured from older donors. PATIENTS AND METHODS: A total of 27 kidneys procured from donors age 70 years or older were transplanted between January 1, 2010, and April 25, 2015. These represented only 4.1% of the 657 kidneys transplanted from deceased donors during this period at the same center...
June 2016: Transplantation Proceedings
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"