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https://www.readbyqxmd.com/read/28646815/integrative-treatment-of-chronic-abdominal-bloating-and-pain-associated-with-overgrowth-of-small-intestinal-bacteria-a-case-report
#1
Laura Kwiatkowski, Elizabeth Rice, Jeffrey Langland
Context • Small intestinal bacterial overgrowth (SIBO) is commonly defined as an increased number of bacteria and/or an abnormal type of bacteria in the small intestine. Conventional treatment for SIBO is typically focused on antibiotics to eradicate the bacterial overgrowth. Numerous studies have demonstrated the antimicrobial activity of herbs, and a diet low in fermentable oligo-, di-, and monosaccharides and polyols (FODMAPs) has been shown to enhance antibiotic therapy. Objective • The current case study intended to evaluate the benefits of an alternative, multifaceted approach-including botanical and homeopathic therapies in conjunction with a low-FODMAP diet-in the treatment of SIBO and its associated symptoms...
July 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28634875/mental-health-care-disparities-now-and-in-the-future
#2
Rahn Bailey, Daphne Sharpe, Tricia Kwiatkowski, Susanne Watson, A Dexter Samuels, Jasmine Hall
In 2014, the USA spent $3 trillion dollars in health care the most per capita in the world. However, the USA lacks universal health coverage, and lags behind other highly developed and wealthy countries in life expectancy (even some "non wealthy" countries have better outcomes). The USA also has deficits in other health outcome measures. Health care costs in the USA continue to rise annually and many patients receive only mediocre care. In addition, clear disparities exist across different communities, socioeconomic groups, and race and ethnicity groups...
June 20, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28617138/targeting-transcription-factor-lysine-acetylation-in-inflammatory-airway-diseases
#3
Thea van den Bosch, Marcel Kwiatkowski, Rainer Bischoff, Frank J Dekker
Asthma and chronic obstructive pulmonary disease are inflammatory airway diseases for which alternative therapeutic strategies are urgently needed. Interestingly, HDAC inhibitors show anti-inflammatory effects in mouse models for these diseases. Here we explore underlying mechanisms that may explain these effects. In previous studies, effects of HDAC inhibitors on histone acetylation are often correlated with their effects on gene expression. However, effects of HDAC inhibitors on transcription factors and their acetylation status may be particularly important in explaining these effects...
June 15, 2017: Epigenomics
https://www.readbyqxmd.com/read/28613922/apparent-sporadic-lymphangioleiomyomatosis-lam-in-a-man-due-to-extreme-mosaicism-for-a-tsc2-mutation
#4
MeiLan K Han, Magdalena E Tyburczy, Thomas N Darling, Ella A Kazerooni, Jeffrey L Myers, Francis X McCormack, Joel Moss, David J Kwiatkowski
No abstract text is available yet for this article.
June 14, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28612053/micro-epidemiological-structuring-of-plasmodium-falciparum-parasite-populations-in-regions-with-varying-transmission-intensities-in-africa
#5
Irene Omedo, Polycarp Mogeni, Teun Bousema, Kirk Rockett, Alfred Amambua-Ngwa, Isabella Oyier, Jennifer C Stevenson, Amrish Y Baidjoe, Etienne P de Villiers, Greg Fegan, Amanda Ross, Christina Hubbart, Anne Jeffreys, Thomas N Williams, Dominic Kwiatkowski, Philip Bejon
Background: The first models of malaria transmission assumed a completely mixed and homogeneous population of parasites.  Recent models include spatial heterogeneity and variably mixed populations. However, there are few empiric estimates of parasite mixing with which to parametize such models. Methods: Here we genotype 276 single nucleotide polymorphisms (SNPs) in 5199 P. falciparum isolates from two Kenyan sites and one Gambian site to determine the spatio-temporal extent of parasite mixing, and use Principal Component Analysis (PCA) and linear regression to examine the relationship between genetic relatedness and relatedness in space and time for parasite pairs...
2017: Wellcome Open Research
https://www.readbyqxmd.com/read/28598439/erratum-lkb1-inactivation-drives-lung-cancer-lineage-switching-governed-by-polycomb-repressive-complex-2
#6
Haikuo Zhang, Christine Fillmore Brainson, Shohei Koyama, Amanda J Redig, Ting Chen, Shuai Li, Manav Gupta, Carolina Garcia-de-Alba, Margherita Paschini, Grit S Herter-Sprie, Gang Lu, Xin Zhang, Bryan P Marsh, Stephanie J Tuminello, Chunxiao Xu, Zhao Chen, Xiaoen Wang, Esra A Akbay, Mei Zheng, Sangeetha Palakurthi, Lynette M Sholl, Anil K Rustgi, David J Kwiatkowski, J Alan Diehl, Adam J Bass, Norman E Sharpless, Glenn Dranoff, Peter S Hammerman, Hongbin Ji, Nabeel Bardeesy, Dieter Saur, Hideo Watanabe, Carla F Kim, Kwok-Kin Wong
This corrects the article DOI: 10.1038/ncomms14922.
June 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28586030/expression-of-the-ep300-tp53-and-bax-genes-in-colorectal-cancer-correlations-with-clinicopathological-parameters-and-survival
#7
Anna E Kowalczyk, Bartlomiej E Krazinski, Janusz Godlewski, Jolanta Kiewisz, Przemyslaw Kwiatkowski, Agnieszka Sliwinska-Jewsiewicka, Jacek Kiezun, Marian Sulik, Zbigniew Kmiec
E1A binding protein P300 (EP300), tumor protein P53 (TP53) and BCL2 associated X, apoptosis regulator (BAX) genes encode proteins which cooperate to regulate important cellular processes. The present study aimed to determine the expression levels of EP300, TP53 and BAX in colorectal cancer (CRC) and to investigate their prognostic value and association with the progression of CRC. Tumor and matched unchanged colorectal tissues were collected from 121 CRC patients. Quantitative polymerase chain reaction and immunohistochemistry were used to assess the mRNA and protein levels of the studied genes...
June 1, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28583029/p-gp-expression-levels-in-the-erythrocytes-of-brown-trout-a-new-tool-for-aquatic-sentinel-biomarker-development
#8
Emeline Valton, Ivan Wawrzyniak, Christian Amblard, Bruno Combourieu, Marie-Laure Bayle, François Desmolles, Fabrice Kwiatkowski, Frédérique Penault-Llorca, Mahchid Bamdad
CONTEXT: P-glycoprotein (P-gp) is a ubiquitous membrane detoxification pump involved in cellular defence against xenobiotics. Blood is a hub for the trade and transport of physiological molecules and xenobiotics. Our recent studies have highlighted the expression of a 140-kDa P-gp in brown trout erythrocytes in primary cell culture and its dose-dependent response to Benzo[a]pyrene pollutant. OBJECTIVE: The purpose of this study was focused on using P-gp expression in brown trout erythrocytes as a biomarker for detecting the degree of river pollution...
June 19, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28571996/the-effect-of-the-use-of-a-tnf-alpha-inhibitor-in-hypothermic-machine-perfusion-on-kidney-function-after-transplantation
#9
Piotr Diuwe, Piotr Domagala, Magdalena Durlik, Janusz Trzebicki, Andrzej Chmura, Artur Kwiatkowski
One of the most important problems in transplantation medicine is the ischemia/reperfusion injury of the organs to be transplanted. The aim of the present study was to assess the effect of tumor necrosis factor-alpha (TNF-alpha) inhibitor etanercept on the machine perfusion hypothermia of renal allograft kidney function and organ perfusion. No statistically significant differences were found in the impact of the applied intervention on kidney machine perfusion during which the average flow and vascular resistance were evaluated...
May 29, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28571558/protein-profile-analysis-of-two-australian-snake-venoms-by-one-dimensional-gel-electrophoresis-and-ms-ms-experiments
#10
Dessi Georgieva, Diana Hildebrand, Rodrigo Simas, Monika A Coronado, Marcel Kwiatkowski, Hartmut Schlüter, Raghuvir Arni, Patrick Spencer, Christian Betzel
The Pseudechis colletti and Pseudechis butleri venoms were analyzed by 1-D gel electrophoresis, followed by mass spectrometric analysis of tryptic peptides obtained from the protein bands. Both venoms contain highly potent pharmacologically active components, which were assigned to the following protein families: basic and acidic phospholipases A2 (PLA2s), L-amino acid oxidases (LAAOs), P-III metalloproteinases (P-III SVMPs), 5'-nucleotidases (5'-NTDs), cysteine-rich secretory proteins (CRISPs), venom nerve growth factors (VNGFs) and post-synaptic neurotoxins...
May 31, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28570520/measuring-protein-binding-to-f-actin-by-co-sedimentation
#11
Jonathon A Heier, Daniel J Dickinson, Adam V Kwiatkowski
Filamentous actin (F-actin) organization within cells is regulated by a large number of actin-binding proteins that control actin nucleation, growth, cross-linking and/or disassembly. This protocol describes a technique - the actin co-sedimentation, or pelleting, assay - to determine whether a protein or protein domain binds F-actin and to measure the affinity of the interaction (i.e., the dissociation equilibrium constant). In this technique, a protein of interest is first incubated with F-actin in solution...
May 18, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28569765/corrigendum-small-genomic-insertions-form-enhancers-that-misregulate-oncogenes
#12
Brian J Abraham, Denes Hnisz, Abraham S Weintraub, Nicholas Kwiatkowski, Charles H Li, Zhaodong Li, Nina Weichert-Leahey, Sunniyat Rahman, Yu Liu, Julia Etchin, Benshang Li, Shuhong Shen, Tong Ihn Lee, Jinghui Zhang, A Thomas Look, Marc R Mansour, Richard A Young
This corrects the article DOI: 10.1038/ncomms14385.
June 1, 2017: Nature Communications
https://www.readbyqxmd.com/read/28569239/environmental-noise-spectroscopy-with-qubits-subjected-to-dynamical-decoupling
#13
Piotr Szańkowski, Guy Ramon, Jan Krzywda, Damian Kwiatkowski, Lukasz Cywinski
A qubit subjected to pure dephasing due to classical Gaussian noise can be turned into a spectrometer of this noise (a sensor from readout of which one can reconstruct the power spectral density of the noise) by subjecting it to a properly chosen dynamical decoupling (DD) sequence. We review the theory behind this DD-based noise spectroscopy technique, paying special attention to issues that arise when the environmental noise is non-Gaussian and/or it has truly quantum properties. While we focus on theoretical basis of the method, we connect the discussed concepts with specific experiments, and we also give an overview of environmental noise models relevant for solid-state based qubits (quantum-dot based spin qubits, superconducting qubits, and NV centers in diamond)...
June 1, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28551630/expression-and-prognostic-significance-of-ep300-tp53-and-bax-in-clear-cell-renal-cell-carcinoma
#14
Janusz Godlewski, Bartlomiej E Krazinski, Anna E Kowalczyk, Jolanta Kiewisz, Jacek Kiezun, Przemyslaw Kwiatkowski, Agnieszka Sliwińska-Jewsiewicka, Piotr W Wierzbicki, Zbigniew Kmieć
BACKGROUND: Histone acetyltransferase E1A-binding protein p300 (EP300), tumor protein p53 (TP53) and B-cell lymphoma-2-associated X protein (BAX) contribute to the regulation of the cell cycle and apoptosis, cellular processes that are often impaired in cancer cells. The aim of this study was to determine the expression levels of EP300, TP53 and BAX genes and their respective proteins in clear cell renal cell carcinoma (ccRCC) and evaluate the value of these factors as prognostic factors...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28528867/a-pan-cancer-proteogenomic-atlas-of-pi3k-akt-mtor-pathway-alterations
#15
Yiqun Zhang, Patrick Kwok-Shing Ng, Melanie Kucherlapati, Fengju Chen, Yuexin Liu, Yiu Huen Tsang, Guillermo de Velasco, Kang Jin Jeong, Rehan Akbani, Angela Hadjipanayis, Angeliki Pantazi, Christopher A Bristow, Eunjung Lee, Harshad S Mahadeshwar, Jiabin Tang, Jianhua Zhang, Lixing Yang, Sahil Seth, Semin Lee, Xiaojia Ren, Xingzhi Song, Huandong Sun, Jonathan Seidman, Lovelace J Luquette, Ruibin Xi, Lynda Chin, Alexei Protopopov, Thomas F Westbrook, Carl Simon Shelley, Toni K Choueiri, Michael Ittmann, Carter Van Waes, John N Weinstein, Han Liang, Elizabeth P Henske, Andrew K Godwin, Peter J Park, Raju Kucherlapati, Kenneth L Scott, Gordon B Mills, David J Kwiatkowski, Chad J Creighton
Molecular alterations involving the PI3K/AKT/mTOR pathway (including mutation, copy number, protein, or RNA) were examined across 11,219 human cancers representing 32 major types. Within specific mutated genes, frequency, mutation hotspot residues, in silico predictions, and functional assays were all informative in distinguishing the subset of genetic variants more likely to have functional relevance. Multiple oncogenic pathways including PI3K/AKT/mTOR converged on similar sets of downstream transcriptional targets...
June 12, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28526297/modeling-the-structure-of-keratin-1-and-10-terminal-domains-and-their-misassembly-in-keratoderma
#16
Cedric Badowski, Adelene Y L Sim, Chandra Verma, Ildikó Szeverényi, Chidambaram Natesavelalar, Ana Terron-Kwiatkowski, John Harper, Edel A O'Toole, E Birgitte Lane
The terminal domains of suprabasal keratins of the skin epithelium are very resistant to evidence-based structural analysis because of their inherent flexibility and lack of predictable structure. We present a model for the structure and interactions of the head and tail domains of epidermal keratins K1 and K10, based on all-atom 3D simulations of keratin primary amino acid sequences, and tyrosine phosphorylation predictions, extracted from published databases. We observed that K1 and K10 end domains are likely to form a tetrameric terminal domain complex (TTDC) incorporating a reversibly extendable region potentially acting as a molecular spring...
May 16, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28522690/resistance-to-malaria-through-structural-variation-of-red-blood-cell-invasion-receptors
#17
Ellen M Leffler, Gavin Band, George B J Busby, Katja Kivinen, Quang Si Le, Geraldine M Clarke, Kalifa A Bojang, David J Conway, Muminatou Jallow, Fatoumatta Sisay-Joof, Edith C Bougouma, Valentina D Mangano, David Modiano, Sodiomon B Sirima, Eric Achidi, Tobias O Apinjoh, Kevin Marsh, Carolyne M Ndila, Norbert Peshu, Thomas N Williams, Chris Drakeley, Alphaxard Manjurano, Hugh Reyburn, Eleanor Riley, David Kachala, Malcolm Molyneux, Vysaul Nyirongo, Terrie Taylor, Nicole Thornton, Louise Tilley, Shane Grimsley, Eleanor Drury, Jim Stalker, Victoria Cornelius, Christina Hubbart, Anna E Jeffreys, Kate Rowlands, Kirk A Rockett, Chris C A Spencer, Dominic P Kwiatkowski
The malaria parasite Plasmodium falciparum invades human red blood cells via interactions between host and parasite surface proteins. By analyzing genome sequence data from human populations, including 1269 individuals from sub-Saharan Africa, we identify a diverse array of large copy number variants affecting the host invasion receptor genes GYPA and GYPB We find that a nearby association with severe malaria is explained by a complex structural rearrangement involving the loss of GYPB and gain of two GYPB-A hybrid genes, which encode a serologically distinct blood group antigen known as Dantu...
May 18, 2017: Science
https://www.readbyqxmd.com/read/28509311/ultrastructural-characteristics-of-myenteric-plexus-in-patients-with-colorectal-cancer
#18
Agata Zauszkiewicz-Pawlak, Janusz Godlewski, Przemyslaw Kwiatkowski, Zbigniew Kmiec
INTRODUCTION: It have been found previously that colorectal cancer (CRC) is accompanied by atrophy of myenteric plexuses (MPs) localized close to the tumor. The aim of the study was to compare ultrastructure of MPs localized in the unchanged part of the colon wall distant to CRC tumor with the ultrastructure of MPs in the vicinity of CRC tumor. MATERIAL AND METHODS: The present study was conducted using post-operative material derived from 11 patients with CRC. Samples of colon wall were taken from the margin of cancer invasion and from a macroscopically unchanged segment of the large intestine, immediately fixed and processed according to the standard protocol for transmission electron microscopy studies...
2017: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/28495449/peripheral-circulatory-disorders-in-essential-thrombocythemia
#19
Rafał Małecki, Małgorzata Gacka, Żanna Fiodorenko-Dumas, Ilias Dumas, Jacek Kwiatkowski, Rajmund Adamiec, Małgorzata Kuliszkiewicz-Janus
A significant amount of patients with essential thrombocythemia (ET) complain of symptoms including distal parts of the extremities (e.g., paresthesias or Raynaud's phenomenon). The aim of the present study was to examine peripheral circulation in the upper extremities of individuals with ET. The study included 45 ET patients and 30 control subjects. All participants were subjected to thermography, photoplethysmography, impedance plethysmography, and applanation tonometry pulse wave analysis. The patients with ET differed significantly from the control subjects in terms of 3rd finger skin temperature (mean 31...
May 7, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28494217/urinary-il-8-is-a-marker-of-early-and-long-term-graft-function-after-renal-transplantation
#20
Ewa Kwiatkowska, Leszek Domański, Joanna Bober, Krzysztof Safranow, Jolanta Szymańska-Pasternak, Aneta Sulecka, Andrzej Pawlik, Kazimierz Ciechanowski, Sebastian Kwiatkowski
In this study, we examined whether the IL-8 content of urine sampled on day 1 and day 14 after renal transplantation is a marker of early and long-term renal function. Moreover, we assessed whether its concentration is positively correlated with the matrix metalloproteinase-9 (MMP-9) content of urine sampled on day 1 and day 30 and 12 months after renal transplantation. Our analysis covered 87 patients who underwent a kidney transplant. The patients were observed for an average of 30 months (12-60 months)...
November 2017: Renal Failure
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