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Hugo Villamil-Ramírez, Paola León-Mimila, Luis R Macias-Kauffer, Adrián Canizalez-Román, Marisela Villalobos-Comparán, Nidia León-Sicairos, Joel Vega-Badillo, Fausto Sánchez-Muñoz, Blanca López-Contreras, Sofía Morán-Ramos, Teresa Villarreal-Molina, Luis C Zurita, Francisco Campos-Pérez, Adriana Huertas-Vazquez, Rafael Bojalil, Sandra Romero-Hidalgo, Carlos A Aguilar-Salinas, Samuel Canizales-Quinteros
Obesity is a major public health concern in Mexico and worldwide. Although the estimated heritability is high, common variants identified by genome-wide association studies explain only a small proportion of this heritability. A combination of linkage and association strategies could be a more robust and powerful approach to identify other obesity-susceptibility variants. We thus sought to identify novel genetic variants associated with obesity-related traits in the Mexican population by combining these methods...
November 24, 2016: Journal of Human Genetics
J A Grossberg, R A Hanel, G Dabus, K Keigher, D C Haussen, E Sauvageau, I Linfante, D Gonsales, P Aguilar Salinas, M Bouslama, M Mayich, R G Nogueira, D K Lopes
BACKGROUND: The Low-profile Visualized Intraluminal Support (LVIS) Junior stent is newly approved for the treatment of wide-necked intracranial aneurysms. OBJECTIVE: To report our multicenter experience with use of the LVIS Jr device. METHODS: The neurointerventional databases of the participating institutions were retrospectively reviewed for aneurysms treated with LVIS Jr from the time of Food and Drug Administration approval until February 2016...
October 27, 2016: Journal of Neurointerventional Surgery
Roopa Mehta, Rafael Zubiran, Alexandro Martagon, Alejandra Vazquez-Cardenas, Yayoi Segura-Kato, Maria Teresa Tusie-Luna, Carlos A Aguilar-Salinas
The burden caused by familial hypercholesterolemia (FH) varies among countries and ethnic groups. The prevalence and characteristics of FH in Latin American (LA) countries is largely unknown. We present a systematic review (following the PRISMA statement) of FH in LA countries. The epidemiology, genetics, screening, management and unique challenges encountered in these countries are discussed. Published reports discussing FH in Hispanic or LA groups was considered for analysis. Thirty studies were included representing 10 countries...
October 24, 2016: Journal of Lipid Research
Pedro Aguilar-Salinas, Leonardo B C Brasiliense, Douglas Gonsales, Bartley Mitchell, Andrey Lima, Eric Sauvageau, Ricardo Hanel
Refinements in endovascular technology have revolutionized the treatment of intracranial aneurysms (IAs) with the development of flow-diversion technology. The first generation of the Pipelin Embolization Device (PED) has demonstrated its safety and efficacy. However, the deployment technique was a difficult task that often led to complex maneuvers. The Pipeline Flex Embolization Device (PED Flex) is the second generation and its introduction has arrived with high expectations due to a completely redesigned delivery system that intends to overcome deployment difficulties seen in the previous generation...
October 2016: Expert Review of Medical Devices
Paloma Almeda-Valdes, Carlos A Aguilar-Salinas, Misael Uribe, Samuel Canizales-Quinteros, Nahum Méndez-Sánchez
BACKGROUND: The prevalence of obesity has increased worldwide in parallel with associated metabolic disturbances such as diabetes and non-alcoholic fatty liver disease. OBJECTIVE: The objective of this article is to underscore discrepancies in the standard anthropometric cut-off values and the presence of metabolic disturbances including diabetes and non-alcoholic fatty liver disease caused by biological and ethnic variations. MATERIALS AND METHODS: We performed a literature review regarding the diagnosis and prevalence of obesity, diabetes, metabolic syndrome and non-alcoholic fatty liver disease and about the different available indicators to define obesity...
September 7, 2016: European Journal of Clinical Investigation
Alonso Romo-Romo, Carlos A Aguilar-Salinas, Griselda X Brito-Córdova, Rita A Gómez Díaz, David Vilchis Valentín, Paloma Almeda-Valdes
BACKGROUND: The effects of non-nutritive sweeteners (NNS) on glucose metabolism and appetite regulating hormones are not clear. There is an ongoing debate concerning NNS use and deleterious changes in metabolism. OBJECTIVES: The aim of this review is to analyze the scientific available evidence regarding the effects of NNS on glucose metabolism and appetite regulating hormones. DATA SOURCES AND STUDY ELIGIBILITY CRITERIA: We identified human observational studies evaluating the relation between NNS consumption and obesity, diabetes, and metabolic syndrome, in addition to clinical trials evaluating the effects of NNS in glucose metabolism and appetite regulating hormones...
2016: PloS One
Rita A Gómez-Díaz, Mónica Patricia Gómez-Medina, Eleazar Ramírez-Soriano, Lucio López-Robles, Carlos A Aguilar-Salinas, Renata Saucedo, Arturo Zarate, Adán Valladares-Salgado, Niels H Wacher
OBJECTIVE: To evaluate the associations of glycemic control and gestational age with ghrelin and proinsulin levels in neonates' umbilical cord blood and mothers' peripheral blood. METHODS: This is a cross-sectional comparative study of twenty-four pregnant women with gestational diabetes (GD), 18 with type 2 diabetes (T2D), and 36 without diabetes, as well as their neonates. Levels of proinsulin, ghrelin, and glycated hemoglobin (HbA1c) in the maternal and neonatal umbilical cord blood samples...
July 20, 2016: Journal of Clinical Research in Pediatric Endocrinology
Guilherme Dabus, Jonathan A Grossberg, C Michael Cawley, Jacques E Dion, Ajit S Puri, Ajay K Wakhloo, Douglas Gonsales, Pedro Aguilar-Salinas, Eric Sauvageau, Italo Linfante, Ricardo A Hanel
BACKGROUND: The off-label use of flow diverters in the treatment of distal aneurysms continues to be debated. OBJECTIVE: To report our multicenter experience in the treatment of complex anterior cerebral artery aneurysms with the Pipeline embolization device (PED). METHODS: The neurointerventional databases of the four participating institutions were retrospectively reviewed for aneurysms treated with PED between October 2011 and January of 2016...
July 5, 2016: Journal of Neurointerventional Surgery
Daniel Cuevas-Ramos, Carlos A Aguilar-Salinas
Fibroblast growth factors (FGFs) are a superfamily of 22 proteins related to cell proliferation and tissue repair after injury. A subgroup of three proteins, FGF19, FGF21, and FGF23, are major endocrine mediators. These three FGFs have low affinity to heparin sulfate during receptor binding; in contrast they have a strong interaction with the cofactor Klotho/β-Klotho. FGF21 has received particular attention because of its key role in carbohydrate, lipids, and energy balance regulation. FGF21 improves glucose and lipids metabolism as well as increasing energy expenditure in animal models and humans...
June 20, 2016: Hormone Molecular Biology and Clinical Investigation
Matilde Valencia-Flores, Babak Mokhlesi, Victoria Santiago-Ayala, Montserrat Reséndiz-García, Alejandra Castaño-Meneses, María Sonia Meza-Vargas, Alejandro Mendoza, Arturo Orea-Tejeda, Guillermo García-Ramos, Carlos Aguilar-Salinas, Donald L Bliwise
BACKGROUND: Although obstructive sleep apnea (OSA) has long been associated with daytime sleepiness, far less is known about its association with the ability to remain awake. The aim of this study was to examine the relative importance of inter-correlated measures of OSA severity (eg, various indices of oxygen saturation and sleep fragmentation) in the ability to stay alert as measured objectively by the Maintenance of Wakefulness Test (MWT), defined by a mean sleep latency of ≥12 min...
April 2016: Sleep Medicine
Jose Luis Acosta, Alma Cristal Hernández-Mondragón, Laura Carolina Correa-Acosta, Sandra Nathaly Cazañas-Padilla, Berenice Chávez-Florencio, Elvia Yamilet Ramírez-Vega, Tulia Monge-Cázares, Carlos A Aguilar-Salinas, Teresa Tusié-Luna, Laura Del Bosque-Plata
BACKGROUND: Genetic variations of the TCF7L2 gene are associated with the development of Type 2 diabetes (T2D). The associated mutations have demonstrated an adaptive role in some human populations, but no studies have determined the impact of evolutionary forces on genetic diversity in indigenous populations from Mexico. Here, we sequenced and analyzed the variation of the TCF7L2 gene in three Amerindian populations and compared the results with whole-exon-sequencing of Mestizo populations from Sigma and the 1000 Genomes Project to assess the roles of selection and recombination in diversity...
2016: BMC Genetics
Stephanie L Schmit, Fredrick R Schumacher, Christopher K Edlund, David V Conti, Ugonna Ihenacho, Peggy Wan, David Van Den Berg, Graham Casey, Barbara K Fortini, Heinz-Josef Lenz, Teresa Tusié-Luna, Carlos A Aguilar-Salinas, Hortensia Moreno-Macías, Alicia Huerta-Chagoya, María Luisa Ordóñez-Sánchez, Rosario Rodríguez-Guillén, Ivette Cruz-Bautista, Maribel Rodríguez-Torres, Linda Liliana Muñóz-Hernández, Olimpia Arellano-Campos, Donají Gómez, Ulices Alvirde, Clicerio González-Villalpando, María Elena González-Villalpando, Loic Le Marchand, Christopher A Haiman, Jane C Figueiredo
Genome-wide association studies (GWAS) have identified 58 susceptibility alleles across 37 regions associated with the risk of colorectal cancer (CRC) with P < 5×10(-8) Most studies have been conducted in non-Hispanic whites and East Asians; however, the generalizability of these findings and the potential for ethnic-specific risk variation in Hispanic and Latino (HL) individuals have been largely understudied. We describe the first GWAS of common genetic variation contributing to CRC risk in HL (1611 CRC cases and 4330 controls)...
June 2016: Carcinogenesis
Alejandra Rodríguez, Luis Gonzalez, Arthur Ko, Marcus Alvarez, Zong Miao, Yash Bhagat, Elina Nikkola, Ivette Cruz-Bautista, Olimpia Arellano-Campos, Linda L Muñoz-Hernández, Maria-Luisa Ordóñez-Sánchez, Rosario Rodriguez-Guillen, Karen L Mohlke, Markku Laakso, Teresa Tusie-Luna, Carlos A Aguilar-Salinas, Päivi Pajukanta
OBJECTIVE: We recently identified a locus on chromosome 18q11.2 for high serum triglycerides in Mexicans. We hypothesize that the lead genome-wide association study single-nucleotide polymorphism rs9949617, or its linkage disequilibrium proxies, regulates 1 of the 5 genes in the triglyceride-associated region. APPROACH AND RESULTS: We performed a linkage disequilibrium analysis and found 9 additional variants in linkage disequilibrium (r(2)>0.7) with the lead single-nucleotide polymorphism...
July 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
Nicholas Keisuke Brownell, Marcela Rodriguez-Flores, Eduardo Garcia-Garcia, Samuel Ordoñez-Ortega, Jorge Oseguera-Moguel, Carlos A Aguilar-Salinas, Paul Poirier
BACKGROUND: Body mass index (BMI) ≥50.0 kg/m(2) has been associated with increased surgical complications and mortality. We assessed echocardiographic characteristics and bariatric surgery complications of patients with BMI ≥50.0 kg/m(2) vs. those in less severe obesity. METHODS AND RESULTS: A retrospective analysis in patients who underwent gastric bypass was performed. Pre-surgery structural characteristics analyzed included left atrial dimension (LA), left ventricle mass (LVM), LVM indexed for height(2...
November 2016: Obesity Surgery
Joel Vega-Badillo, Roxana Gutiérrez-Vidal, Hugo A Hernández-Pérez, Hugo Villamil-Ramírez, Paola León-Mimila, Fausto Sánchez-Muñoz, Sofía Morán-Ramos, Elena Larrieta-Carrasco, Itzel Fernández-Silva, Nahúm Méndez-Sánchez, Armando R Tovar, Francisco Campos-Pérez, Teresa Villarreal-Molina, Rogelio Hernández-Pando, Carlos A Aguilar-Salinas, Samuel Canizales-Quinteros
BACKGROUND AND AIM: Abnormal cholesterol metabolism may contribute to the pathogenesis of non-alcoholic steatohepatitis (NASH) and fibrosis. miR-33 and miR-144 regulate adenosine triphosphate binding cassette transporter (ABCA1) and other target genes involved in cholesterol efflux, fatty acid oxidation and inflammation. We explored relationships between non-alcoholic fatty liver disease (NAFLD) and the hepatic expression of ABCA1/ABCG1, as well as other target genes regulated by miR-33 (carnitine O-octanoyltransferase, CROT and hydroxyacyl-CoA-dehydrogenase β-subunit, HADHB) and miR-144 (toll-like receptor-2, TLR2)...
September 2016: Liver International: Official Journal of the International Association for the Study of the Liver
Rigoberto Pallares-Méndez, Carlos A Aguilar-Salinas, Ivette Cruz-Bautista, Laura Del Bosque-Plata
Metabolomics is a promising approach for the identification of chemical compounds that serve for early detection, diagnosis, prediction of therapeutic response and prognosis of disease. Moreover, metabolomics has shown to increase the diagnostic threshold and prediction of type 2 diabetes. Evidence suggests that branched-chain amino acids, acylcarnitines and aromatic amino acids may play an early role on insulin resistance, exposing defects on amino acid metabolism, β-oxidation, and tricarboxylic acid cycle...
2016: Annals of Medicine
Donají Rodríguez-Ortiz, Azucena Reyes-Pérez, Pablo León, Hugo Sánchez, Maureen Mosti, Carlos A Aguilar-Salinas, David Velázquez-Fernández, Miguel F Herrera
BACKGROUND: Bariatric surgery has proven to provide durable weight loss and control of comorbid conditions, including the metabolic syndrome (MS). Existing definitions of MS have caused substantial confusion regarding their concordance for identifying the same individuals. The aim of this study was to assess the value of 2 different diagnostic guidelines criteria (National Cholesterol Education Adult Treatment Panel III [ATP III] and International Diabetes Federation [IDF]) for the evaluation of remission of MS after Roux-en-Y gastric bypass (RYGB)...
April 2016: Surgery
Benjamin L Brown, Demetrius Lopes, David A Miller, Rabih G Tawk, Leonardo B C Brasiliense, Andrew Ringer, Eric Sauvageau, Ciarán J Powers, Adam Arthur, Daniel Hoit, Kenneth Snyder, Adnan Siddiqui, Elad Levy, L Nelson Hopkins, Hugo Cuellar, Rafael Rodriguez-Mercado, Erol Veznedaroglu, Mandy Binning, J Mocco, Pedro Aguilar-Salinas, Alan Boulos, Junichi Yamamoto, Ricardo A Hanel
OBJECTIVE: The authors sought to determine whether flow diversion with the Pipeline Embolization Device (PED) can approximate microsurgical decompression in restoring function after cranial neuropathy following carotid artery aneurysms. METHODS: This multiinstitutional retrospective study involved 45 patients treated with PED across the United States. All patients included presented between November 2009 and October 2013 with cranial neuropathy (cranial nerves [CNs] II, III, IV, and VI) due to intracranial aneurysm...
April 2016: Journal of Neurosurgery
Nancy E Aguilar-Olivos, Paloma Almeda-Valdes, Carlos A Aguilar-Salinas, Misael Uribe, Nahum Méndez-Sánchez
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. NAFLD is strongly associated with obesity and metabolic syndrome (MetS). Current treatment of NAFLD is based on weight reduction. Bariatric surgery is the most effective treatment for morbid obesity and its associated metabolic comorbidities. There is evidence indicating that bariatric surgery improves histological and biochemical parameters of NAFLD, but currently is not considered a treatment option for NAFLD...
August 2016: Metabolism: Clinical and Experimental
Antonio J Vallejo-Vaz, Sreenivasa Rao Kondapally Seshasai, Della Cole, G Kees Hovingh, John J P Kastelein, Pedro Mata, Frederick J Raal, Raul D Santos, Handrean Soran, Gerald F Watts, Marianne Abifadel, Carlos A Aguilar-Salinas, Asif Akram, Fahad Alnouri, Rodrigo Alonso, Khalid Al-Rasadi, Maciej Banach, Martin P Bogsrud, Mafalda Bourbon, Eric Bruckert, Josip Car, Pablo Corral, Olivier Descamps, Hans Dieplinger, Ronen Durst, Tomas Freiberger, Isabel M Gaspar, Jaques Genest, Mariko Harada-Shiba, Lixin Jiang, Meral Kayikcioglu, Carolyn S P Lam, Gustavs Latkovskis, Ulrich Laufs, Evangelos Liberopoulos, Lennart Nilsson, Børge G Nordestgaard, John M O'Donoghue, Amirhossein Sahebkar, Heribert Schunkert, Abdulla Shehab, Mario Stoll, Ta-Chen Su, Andrey Susekov, Elisabeth Widén, Alberico L Catapano, Kausik K Ray
No abstract text is available yet for this article.
November 2015: Atherosclerosis
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