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Aguilar-Salinas

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https://www.readbyqxmd.com/read/28128799/-concept-of-opinion-leader-recommendations-of-the-committee-on-ethics-and-transparency-in-the-medical-industry-relationship-cetremi-of-the-national-academy-of-medicine-anm
#1
Rubén Burgos, Carlos Alberto Aguilar-Salinas, Leonor Barile-Fabris, Manuel Sigfrido Rangel-Fraustro, Óscar Arrieta, Carlos Campillo, Miguel Ángel Celis, Manuel de la Llata, Judith Domínguez, José Halabe, Sergio Islas, Luis Jasso, Alberto Lifshitz, Mucio Moreno, Ricardo Plancarte, Alejandro Reyes, Antonio Soda, Emma Verástegui, Julio Sotelo
La relación que involucra al médico y la industria abarca un espectro amplio de formas, para lo cual se requiere una exposición clara y transparente de términos y principios. Uno de los objetivos primordiales de la industria es contar con un respaldo académico que le permita dar a conocer las características y las propiedades de sus productos -eficacia, eficiencia y seguridad- con el propósito de ser prescritos y usados. Los fines de la industria son la venta de sus productos, el reconocimiento como empresas de prestigio y la ganancia económica...
January 2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/28126460/laboratory-based-and-office-based-risk-scores-and-charts-to-predict-10-year-risk-of-cardiovascular-disease-in-182-countries-a-pooled-analysis-of-prospective-cohorts-and-health-surveys
#2
Peter Ueda, Mark Woodward, Yuan Lu, Kaveh Hajifathalian, Rihab Al-Wotayan, Carlos A Aguilar-Salinas, Alireza Ahmadvand, Fereidoun Azizi, James Bentham, Renata Cifkova, Mariachiara Di Cesare, Louise Eriksen, Farshad Farzadfar, Trevor S Ferguson, Nayu Ikeda, Davood Khalili, Young-Ho Khang, Vera Lanska, Luz León-Muñoz, Dianna J Magliano, Paula Margozzini, Kelias P Msyamboza, Gerald Mutungi, Kyungwon Oh, Sophal Oum, Fernando Rodríguez-Artalejo, Rosalba Rojas-Martinez, Gonzalo Valdivia, Rainford Wilks, Jonathan E Shaw, Gretchen A Stevens, Janne S Tolstrup, Bin Zhou, Joshua A Salomon, Majid Ezzati, Goodarz Danaei
BACKGROUND: Worldwide implementation of risk-based cardiovascular disease (CVD) prevention requires risk prediction tools that are contemporarily recalibrated for the target country and can be used where laboratory measurements are unavailable. We present two cardiovascular risk scores, with and without laboratory-based measurements, and the corresponding risk charts for 182 countries to predict 10-year risk of fatal and non-fatal CVD in adults aged 40-74 years. METHODS: Based on our previous laboratory-based prediction model (Globorisk), we used data from eight prospective studies to estimate coefficients of the risk equations using proportional hazard regressions...
January 23, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28096140/setting-the-lipid-component-of-the-diet-a-work-in-process
#3
REVIEW
Fabiola M Del Razo Olvera, Marco A Melgarejo Hernández, Roopa Mehta, Carlos A Aguilar Salinas
Some of the most relevant yet controversial issues in nutrition are those surrounding the guidelines on quality and quantity of dietary fat in the prevention and treatment of cardiovascular diseases and coronary heart diseases. Conflicting evidence questions the credibility of the previous dietary guidelines, particularly the quality of the evidence on which these recommendations were based. It is therefore important to explore the changes that have occurred in these guidelines and their influence on the adoption of different dietary patterns over time...
January 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28094565/the-decline-in-hiv-1-drug-resistance-in-heavily-antiretroviral-experienced-patients-is-associated-with-optimized-prescriptions-in-a-treatment-roll-out-program-in-mexico
#4
Juan J Calva, Silvana Larrea, Marco A Tapia-Maltos, Mauricio Ostrosky-Frid, Carolina Lara, Pedro Aguilar-Salinas, Héctor Rivera, Juan P Ramírez
A decrease in the rate of acquired antiretroviral (ARV) drug-resistance (ADR) over time has been documented in high-income settings, but data on the determinants of this phenomenon are lacking. We tested the hypothesis that in heavily ARV-experienced patients in the Mexican ARV therapy (ART) roll-out program, the drop in ADR would be associated with changes in ARV drug usage. Genotypic resistance tests obtained from 974 HIV-infected patients with virologic failure and at least 2 previously failed ARV regimens from throughout the country were analyzed for the presence of nRTI, NNRTI and PI resistance-associated mutations (RAMs)...
January 17, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28049755/prevention-of-diabetes-in-mexico-pragmatic-solutions-for-a-complex-problem
#5
Carlos A Aguilar-Salinas, Hector Bourges Rodriguez, Ernestina Polo Oteyza
The Tenth Nestlé Nutrition Conference, held in Mexico City in November 2014, focused on prevention of type 2 diabetes considering environment, lifestyles, and nutrition. Based on the evidence and recommendations presented during the conference, which are summarized in another article within this supplemental issue, a series of pragmatic proposals to address the environmental, social, and medical factors that have contributed to the growing prevalence of type 2 diabetes in Mexico was formulated. For this article, the actions were organized into 2 conceptual models: one that is applicable for the whole population and the other for at-risk individuals...
January 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/28049745/epidemiology-of-diabetes-mellitus-in-mexico
#6
Omar Y Bello-Chavolla, Rosalba Rojas-Martinez, Carlos A Aguilar-Salinas, Mauricio Hernández-Avila
Type 2 diabetes is the main health problem in Mexico. The large and growing number of cases and the remarkable economic impact of the disease support this statement. The condition is expressed at an earlier age and at a lower body mass index in Mexican mestizos compared with the age and body mass index reported in Caucasians. In addition, Mexican mestizos have an increased susceptibility to developing diabetic nephropathy. The Mexican health system needs major adjustments in order to prevent and treat type 2 diabetes...
January 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/28049744/prevention-of-diabetes-in-mexico-summary-of-evidence-on-preventive-interventions-presented-at-the-2014-nestle-nutrition-conference
#7
Carlos A Aguilar-Salinas, Hector Bourges-Rodriguez, Ernestina Polo-Oteyza
No abstract text is available yet for this article.
January 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/28003539/prenatal-docosahexaenoic-acid-supplementation-does-not-affect-nonfasting-serum-lipid-and-glucose-concentrations-of-offspring-at-4-years-of-age-in-a-follow-up-of-a-randomized-controlled-clinical-trial-in-mexico
#8
Yareni Gutierrez-Gomez, Aryeh D Stein, Usha Ramakrishnan, Albino Barraza-Villarreal, Hortensia Moreno-Macias, Carlos Aguilar-Salinas, Isabelle Romieu, Juan A Rivera
BACKGROUND: Docosahexaenoic acid (DHA) has regulatory effects on lipid and glucose metabolism. Differences in DHA availability during specific developmental windows may program metabolic changes. OBJECTIVE: We investigated the effects of maternal DHA supplementation during pregnancy on the nonfasting serum lipid and glucose concentrations of offspring at 4 y of age. METHODS: We used data from the Prenatal Omega-3 Fatty Acid Supplementation, Growth, and Development trial, a double-blind randomized controlled trial conducted in Mexico...
February 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/27939304/pooling-and-expanding-registries-of-familial-hypercholesterolaemia-to-assess-gaps-in-care-and-improve-disease-management-and-outcomes-rationale-and-design-of-the-global-eas-familial-hypercholesterolaemia-studies-collaboration
#9
MULTICENTER STUDY
Antonio J Vallejo-Vaz, Asif Akram, Sreenivasa Rao Kondapally Seshasai, Della Cole, Gerald F Watts, G Kees Hovingh, John J P Kastelein, Pedro Mata, Frederick J Raal, Raul D Santos, Handrean Soran, Tomas Freiberger, Marianne Abifadel, Carlos A Aguilar-Salinas, Fahad Alnouri, Rodrigo Alonso, Khalid Al-Rasadi, Maciej Banach, Martin P Bogsrud, Mafalda Bourbon, Eric Bruckert, Josip Car, Richard Ceska, Pablo Corral, Olivier Descamps, Hans Dieplinger, Can T Do, Ronen Durst, Marat V Ezhov, Zlatko Fras, Dan Gaita, Isabel M Gaspar, Jaques Genest, Mariko Harada-Shiba, Lixin Jiang, Meral Kayikcioglu, Carolyn S P Lam, Gustavs Latkovskis, Ulrich Laufs, Evangelos Liberopoulos, Jie Lin, Nan Lin, Vincent Maher, Nelson Majano, A David Marais, Winfried März, Erkin Mirrakhimov, André R Miserez, Olena Mitchenko, Hapizah Nawawi, Lennart Nilsson, Børge G Nordestgaard, György Paragh, Zaneta Petrulioniene, Belma Pojskic, Željko Reiner, Amirhossein Sahebkar, Lourdes E Santos, Heribert Schunkert, Abdullah Shehab, M Naceur Slimane, Mario Stoll, Ta-Chen Su, Andrey Susekov, Myra Tilney, Brian Tomlinson, Alexandros D Tselepis, Branislav Vohnout, Elisabeth Widén, Shizuya Yamashita, Alberico L Catapano, Kausik K Ray
BACKGROUND: The potential for global collaborations to better inform public health policy regarding major non-communicable diseases has been successfully demonstrated by several large-scale international consortia. However, the true public health impact of familial hypercholesterolaemia (FH), a common genetic disorder associated with premature cardiovascular disease, is yet to be reliably ascertained using similar approaches. The European Atherosclerosis Society FH Studies Collaboration (EAS FHSC) is a new initiative of international stakeholders which will help establish a global FH registry to generate large-scale, robust data on the burden of FH worldwide...
December 2016: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/27881840/a-combined-linkage-and-association-strategy-identifies-a-variant-near-the-gstp1-gene-associated-with-bmi-in-the-mexican-population
#10
Hugo Villamil-Ramírez, Paola León-Mimila, Luis R Macias-Kauffer, Adrián Canizalez-Román, Marisela Villalobos-Comparán, Nidia León-Sicairos, Joel Vega-Badillo, Fausto Sánchez-Muñoz, Blanca López-Contreras, Sofía Morán-Ramos, Teresa Villarreal-Molina, Luis C Zurita, Francisco Campos-Pérez, Adriana Huertas-Vazquez, Rafael Bojalil, Sandra Romero-Hidalgo, Carlos A Aguilar-Salinas, Samuel Canizales-Quinteros
Obesity is a major public health concern in Mexico and worldwide. Although the estimated heritability is high, common variants identified by genome-wide association studies explain only a small proportion of this heritability. A combination of linkage and association strategies could be a more robust and powerful approach to identify other obesity-susceptibility variants. We thus sought to identify novel genetic variants associated with obesity-related traits in the Mexican population by combining these methods...
November 24, 2016: Journal of Human Genetics
https://www.readbyqxmd.com/read/27789790/treatment-of-wide-necked-aneurysms-with-the-low-profile-visualized-intraluminal-support-lvis-jr-device-a-multicenter-experience
#11
J A Grossberg, R A Hanel, G Dabus, K Keigher, D C Haussen, E Sauvageau, I Linfante, D Gonsales, P Aguilar Salinas, M Bouslama, M Mayich, R G Nogueira, D K Lopes
BACKGROUND: The Low-profile Visualized Intraluminal Support (LVIS) Junior stent is newly approved for the treatment of wide-necked intracranial aneurysms. OBJECTIVE: To report our multicenter experience with use of the LVIS Jr device. METHODS: The neurointerventional databases of the participating institutions were retrospectively reviewed for aneurysms treated with LVIS Jr from the time of Food and Drug Administration approval until February 2016...
October 27, 2016: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/27777316/the-panorama-of-familial-hypercholesterolemia-in-latin-america-a-systematic-review
#12
REVIEW
Roopa Mehta, Rafael Zubirán, Alexandro J Martagón, Alejandra Vazquez-Cárdenas, Yayoi Segura-Kato, María Teresa Tusié-Luna, Carlos A Aguilar-Salinas
The burden caused by familial hypercholesterolemia (FH) varies among countries and ethnic groups. The prevalence and characteristics of FH in Latin American (LA) countries is largely unknown. We present a systematic review (following the PRISMA statement) of FH in LA countries. The epidemiology, genetics, screening, management, and unique challenges encountered in these countries are discussed. Published reports discussing FH in Hispanic or LA groups was considered for analysis. Thirty studies were included representing 10 countries...
December 2016: Journal of Lipid Research
https://www.readbyqxmd.com/read/27647130/evaluation-of-pipeline-flex-delivery-system-for-the-treatment-of-unruptured-aneurysms
#13
Pedro Aguilar-Salinas, Leonardo B C Brasiliense, Douglas Gonsales, Bartley Mitchell, Andrey Lima, Eric Sauvageau, Ricardo Hanel
Refinements in endovascular technology have revolutionized the treatment of intracranial aneurysms (IAs) with the development of flow-diversion technology. The first generation of the Pipelin Embolization Device (PED) has demonstrated its safety and efficacy. However, the deployment technique was a difficult task that often led to complex maneuvers. The Pipeline Flex Embolization Device (PED Flex) is the second generation and its introduction has arrived with high expectations due to a completely redesigned delivery system that intends to overcome deployment difficulties seen in the previous generation...
October 2016: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/27600089/impact-of-anthropometric-cut-off-values-in-determining-the-prevalence-of-metabolic-alterations
#14
REVIEW
Paloma Almeda-Valdes, Carlos A Aguilar-Salinas, Misael Uribe, Samuel Canizales-Quinteros, Nahum Méndez-Sánchez
BACKGROUND: The prevalence of obesity has increased worldwide in parallel with associated metabolic disturbances such as diabetes and non-alcoholic fatty liver disease. OBJECTIVE: The objective of this article is to underscore discrepancies in the standard anthropometric cut-off values and the presence of metabolic disturbances including diabetes and non-alcoholic fatty liver disease caused by biological and ethnic variations. MATERIALS AND METHODS: We performed a literature review regarding the diagnosis and prevalence of obesity, diabetes, metabolic syndrome and non-alcoholic fatty liver disease and about the different available indicators to define obesity...
November 2016: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27537496/effects-of-the-non-nutritive-sweeteners-on-glucose-metabolism-and-appetite-regulating-hormones-systematic-review-of-observational-prospective-studies-and-clinical-trials
#15
Alonso Romo-Romo, Carlos A Aguilar-Salinas, Griselda X Brito-Córdova, Rita A Gómez Díaz, David Vilchis Valentín, Paloma Almeda-Valdes
BACKGROUND: The effects of non-nutritive sweeteners (NNS) on glucose metabolism and appetite regulating hormones are not clear. There is an ongoing debate concerning NNS use and deleterious changes in metabolism. OBJECTIVES: The aim of this review is to analyze the scientific available evidence regarding the effects of NNS on glucose metabolism and appetite regulating hormones. DATA SOURCES AND STUDY ELIGIBILITY CRITERIA: We identified human observational studies evaluating the relation between NNS consumption and obesity, diabetes, and metabolic syndrome, in addition to clinical trials evaluating the effects of NNS in glucose metabolism and appetite regulating hormones...
2016: PloS One
https://www.readbyqxmd.com/read/27476441/lower-plasma-ghrelin-levels-are-found-in-women-with-diabetes-complicated-pregnancies
#16
Rita Angélica Gómez-Díaz, Monica P Gómez-Medina, Eleazar Ramírez-Soriano, Lucio López-Robles, Carlos A Aguilar-Salinas, Renata Saucedo, Arturo Zarate, Adan Valladares-Salgado, Niels H Wacher
OBJECTIVE: To evaluate the associations of glycemic control and gestational age with ghrelin and proinsulin levels in cord blood and mothers' peripheral blood during pregnancy. METHODS: This is a cross-sectional comparative study of twenty-four pregnant women with gestational diabetes (GD), 18 with type 2 diabetes mellitus (T2DM), and 36 without diabetes, as well as their neonates. Levels of proinsulin, ghrelin, and glycated hemoglobin A1c (HbA1c) were measured from maternal blood during the last week before caesarian delivery and in neonatal umbilical cord blood samples...
1, 2016: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/27382125/treatment-of-complex-anterior-cerebral-artery-aneurysms-with-pipeline-flow-diversion-mid-term-results
#17
REVIEW
Guilherme Dabus, Jonathan A Grossberg, C Michael Cawley, Jacques E Dion, Ajit S Puri, Ajay K Wakhloo, Douglas Gonsales, Pedro Aguilar-Salinas, Eric Sauvageau, Italo Linfante, Ricardo A Hanel
BACKGROUND: The off-label use of flow diverters in the treatment of distal aneurysms continues to be debated. OBJECTIVE: To report our multicenter experience in the treatment of complex anterior cerebral artery aneurysms with the Pipeline embolization device (PED). METHODS: The neurointerventional databases of the four participating institutions were retrospectively reviewed for aneurysms treated with PED between October 2011 and January of 2016...
July 5, 2016: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/27318658/modulation-of-energy-balance-by-fibroblast-growth-factor-21
#18
Daniel Cuevas-Ramos, Carlos A Aguilar-Salinas
Fibroblast growth factors (FGFs) are a superfamily of 22 proteins related to cell proliferation and tissue repair after injury. A subgroup of three proteins, FGF19, FGF21, and FGF23, are major endocrine mediators. These three FGFs have low affinity to heparin sulfate during receptor binding; in contrast they have a strong interaction with the cofactor Klotho/β-Klotho. FGF21 has received particular attention because of its key role in carbohydrate, lipids, and energy balance regulation. FGF21 improves glucose and lipids metabolism as well as increasing energy expenditure in animal models and humans...
June 20, 2016: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/27318233/intermittent-hypoxemia-and-sleep-fragmentation-associations-with-daytime-alertness-in-obese-sleep-apnea-patients-living-at-moderate-altitude
#19
Matilde Valencia-Flores, Babak Mokhlesi, Victoria Santiago-Ayala, Montserrat Reséndiz-García, Alejandra Castaño-Meneses, María Sonia Meza-Vargas, Alejandro Mendoza, Arturo Orea-Tejeda, Guillermo García-Ramos, Carlos Aguilar-Salinas, Donald L Bliwise
BACKGROUND: Although obstructive sleep apnea (OSA) has long been associated with daytime sleepiness, far less is known about its association with the ability to remain awake. The aim of this study was to examine the relative importance of inter-correlated measures of OSA severity (eg, various indices of oxygen saturation and sleep fragmentation) in the ability to stay alert as measured objectively by the Maintenance of Wakefulness Test (MWT), defined by a mean sleep latency of ≥12 min...
April 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27230431/rare-intronic-variants-of-tcf7l2-arising-by-selective-sweeps-in-an-indigenous-population-from-mexico
#20
Jose Luis Acosta, Alma Cristal Hernández-Mondragón, Laura Carolina Correa-Acosta, Sandra Nathaly Cazañas-Padilla, Berenice Chávez-Florencio, Elvia Yamilet Ramírez-Vega, Tulia Monge-Cázares, Carlos A Aguilar-Salinas, Teresa Tusié-Luna, Laura Del Bosque-Plata
BACKGROUND: Genetic variations of the TCF7L2 gene are associated with the development of Type 2 diabetes (T2D). The associated mutations have demonstrated an adaptive role in some human populations, but no studies have determined the impact of evolutionary forces on genetic diversity in indigenous populations from Mexico. Here, we sequenced and analyzed the variation of the TCF7L2 gene in three Amerindian populations and compared the results with whole-exon-sequencing of Mestizo populations from Sigma and the 1000 Genomes Project to assess the roles of selection and recombination in diversity...
2016: BMC Genetics
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