keyword
https://read.qxmd.com/read/25929406/purine-nucleoside-phosphorylase-and-the-enzymatic-antioxidant-defense-system-in-breast-milk-from-women-with-different-levels-of-arsenic-exposure
#21
JOURNAL ARTICLE
Ramón Gaxiola-Robles, Vanessa Labrada-Martagón, Oscar Kurt Bitzer-Quintero, Tania Zenteno-Savín, Lía Celina Méndez-Rodríguez
Purine nucleoside phosphorylase (PNP) is an ubiquitous enzyme which plays an important role in arsenic (As) detoxification. As is a toxic metalloid present in air, soil and water; is abundant in the environment and is readily transferred along the trophic chain, being found even in human breast milk. Milk is the main nutrient source for the growth and development of neonates. Information on breast milk synthesis and its potential defense mechanism against As toxicity is scarce. In this study, PNP and antioxidant enzymes activities, as well as glutathione (GSH) and total arsenic (TAs) concentrations, were quantified in breast milk samples...
May 1, 2015: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://read.qxmd.com/read/25849936/the-amelioration-of-hepatic-steatosis-by-thyroid-hormone-receptor-agonists-is-insufficient-to-restore-insulin-sensitivity-in-ob-ob-mice
#22
JOURNAL ARTICLE
Alexandro J Martagón, Jean Z Lin, Stephanie L Cimini, Paul Webb, Kevin J Phillips
Thyroid hormone receptor (TR) agonists have been proposed as therapeutic agents to treat non-alcoholic fatty liver disease (NAFLD) and insulin resistance. We investigated the ability of the TR agonists GC-1 and KB2115 to reduce hepatic steatosis in ob/ob mice. Both compounds markedly reduced hepatic triglyceride levels and ameliorated hepatic steatosis. However, the amelioration of fatty liver was not sufficient to improve insulin sensitivity in these mice and reductions in hepatic triglycerides did not correlate with improvements in insulin sensitivity or glycemic control...
2015: PloS One
https://read.qxmd.com/read/25695296/poor-performance-of-the-total-kappa-lambda-light-chain-quantification-in-the-diagnosis-and-follow-up-of-patients-with-multiple-myeloma
#23
COMPARATIVE STUDY
Gabriela Zamora-Ortiz, Sara Velázquez-Sánchez-de-Cima, Jesus Hernández-Reyes, Nora Angela Martagón-Herrera, Alejandro Ruiz-Argüelles, Guillermo J Ruiz-Delgado, Guillermo J Ruiz-Argüelles
BACKGROUND: The gold standard for paraproteinemia screening in plasma cell disorders has been serum protein electro- phoresis (SPE) with immunofixation electrophoresis (IFx); serum total and free light chain quantifications have also been used. OBJECTIVE: To define the role of SPE, IFx and serum total light chain (sLC) determinations in patients with multiple myeloma (MM), both at diagnosis and at maximum response during treatment follow-up. MATERIAL AND METHODS: These serological studies were performed in a group of 62 patients with MM at diagnosis, and in a subset of 29 patients at the point of maximum response to treatment...
July 2014: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/25583006/effect-of-pre-storage-on-lilium-martagon-l-seed-longevity-following-cryopreservation
#24
COMPARATIVE STUDY
M Urbaniec-Kiepura, A Bach
BACKGROUND: The aim of the study was to compare different strategies for the cryopreservation of Lilium martagon L. seeds. MATERIALS AND METHODS: The starting material was seeds of the martagon lily (without or with a special pretreatment involving sucrose pre-culture dehydratation and desiccation) subjected to cryopreservation after preliminary storage under conventional conditions (-5 degree C, 5 degree C, or 15 degree C). The effects of storage, pretreatment and cryopreservation on the seeds were assessed in terms of seed germination and phenotypic changes in the seedlings derived from those seeds...
November 2014: Cryo Letters
https://read.qxmd.com/read/25208800/interaction-between-mercury-hg-arsenic-as-and-selenium-se-affects-the-activity-of-glutathione-s-transferase-in-breast-milk-possible-relationship-with-fish-and-sellfish-intake
#25
JOURNAL ARTICLE
Ramón Gaxiola-Robles, Vanessa Labrada-Martagón, Alfredo de Jesús Celis de la Rosa, Baudilio Acosta-Vargas, Lía Celina Méndez-Rodríguez, Tania Zenteno-Savín
Breast milk is regarded as an ideal source of nutrients for the growth and development of neonates, but it can also be a potential source of pollutants. Mothers can be exposed to different contaminants as a result of their lifestyle and environmental pollution. Mercury (Hg) and arsenic (As) could adversely affect the development of fetal and neonatal nervous system. Some fish and shellfish are rich in selenium (Se), an essential trace element that forms part of several enzymes related to the detoxification process, including glutathione S-transferase (GST)...
2014: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://read.qxmd.com/read/24762722/paroxysmal-nocturnal-hemoglobinuria-in-m%C3%A3-xico-a-30-year-single-institution-experience
#26
JOURNAL ARTICLE
Jesús Hernández-Reyes, Mónica Patricia González-Ramírez, Nora Ángela Martagón-Herrera, Alan Daniel Rosales-Durón, Guillermo J Ruiz-Delgado, Guillermo J Ruiz-Argüelles
BACKGROUND: Paroxysmal nocturnal hemoglobinuria (PNH) stems from chronic, complement-mediated, intravascular hemolysis, which results in anemia, hemoglobinuria, fatigue, and other hemolysis-related disabling symptoms. Novel diagnostic methods have led into an increased identification of the disease. AIMS: To analyze the salient features of patients with PNH identified in a single institution in México, in a 30-year period. MATERIAL AND METHODS: The records of 31 patients with PNH identified between 1984 and 2013 were reviewed; 20 females...
January 2014: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/24556580/oral-versus-intravenous-fludarabine-as-part-of-a-reduced-intensity-conditioning-for-allogeneic-stem-cell-transplantation
#27
COMPARATIVE STUDY
Sara Velázquez-Sánchez-de-Cima, Gabriela Zamora-Ortiz, Jesús Hernández-Reyes, Alan Daniel Rosales-Durón, Mónica Patricia González-Ramírez, Nora Angela Martagón-Herrera, Guillermo J Ruiz-Delgado, Guillermo J Ruiz-Argüelles
BACKGROUND: In 2003, oral fludarabine was introduced in the USA for the treatment of patients with hematologic malignancies as an alternative to its intravenous (i.v.) formulation; in 2008, it was introduced in México while the i.v. formulation was withdrawn. Accordingly, i.v. fludarabine had to be replaced by oral fludarabine as part of the conditioning regimen employed to conduct allogeneic stem cell transplantation in México. METHODS: Nonrandomized retrospective analysis of 55 patients conditioned with oral fludarabine compared with 113 patients conditioned with the i...
2014: Acta Haematologica
https://read.qxmd.com/read/24506367/-lipid-peroxidation-and-the-response-of-the-antioxidant-defense-system-in-the-obese-type-2-diabetic-compared-with-the-non-obese-type-2-diabetic
#28
JOURNAL ARTICLE
Ramón Gaxiola-Robles, Oscar Kurt Bitzer-Quintero, Lía Celina Méndez-Rodríguez, Vanessa Labrada-Martagón, Adolfo García-González, Luis Javier Ramírez-Jirano, Marcela Veléz-Alavez, Tania Zenteno-Savín
INTRODUCTION: Diabetes is associated with increased lipid peroxidation, quantified as the levels of thiobarbituric acid reactive substances (TBARS). In parallel, the antioxidant defense system (ADS) reacts to diminish the oxidative damage. OBJECTIVE: To determine the levels of lipid peroxidation and the activity of antioxidant enzymes in obese type 2 diabetic (DM2) individuals compared to non-obese DM2 individuals. METHODS: Lipid peroxidation was quantified by measuring TBARS and the ADS response by measuring the activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)...
November 2013: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://read.qxmd.com/read/24498208/lilium-spp-pollen-in-china-liliaceae-taxonomic-and-phylogenetic-implications-and-pollen-evolution-related-to-environmental-conditions
#29
JOURNAL ARTICLE
Yun-peng Du, Chi Wei, Zhong-xuan Wang, Shuang Li, Heng-bin He, Gui-xia Jia
Recent molecular and karyologic studies have significantly modified delimitation of Lilium. However, despite the importance of pollen evolution in the genus comprehensive studies with electron microscopy and evaluation of pollen evolution are lacking. Therefore, we studied pollen morphology in a sample of 65 individuals from 37 taxa covering all the sections distributed in the world, using scanning electron microscopy. Our collection of 49 individuals from 21 taxa covering all five sections in China was also included in the database...
2014: PloS One
https://read.qxmd.com/read/24212402/molecular-phylogeny-and-genetic-variation-in-the-genus-lilium-native-to-china-based-on-the-internal-transcribed-spacer-sequences-of-nuclear-ribosomal-dna
#30
JOURNAL ARTICLE
Yun-peng Du, Heng-bin He, Zhong-xuan Wang, Shuang Li, Chi Wei, Xiao-na Yuan, Qi Cui, Gui-xia Jia
We present a comprehensive phylogeny derived from nuclear ribosomal DNA (nrDNA) for 214 samples representing 98 species and five varieties, including 44 species and five varieties native to China. Our collection of 25 species and five varieties (44 samples) covering all five sections of the genus (Comber) distributed in China also were included in the internal transcribed spacer (ITS) database. This study incorporates previous research with an emphasis on Chinese species, including the controversial subsection, Sinomartagon 5c Comber...
March 2014: Journal of Plant Research
https://read.qxmd.com/read/24108450/toxoplasma-encephalitis-in-an-hiv-infected-patient-on-highly-active-antiretroviral-therapy-despite-sustained-immune-response
#31
JOURNAL ARTICLE
Auras R Atreya, Sonali Arora, Vijay T Gadiraju, José Martagon-Villamil, Daniel J Skiest
Toxoplasma encephalitis (TE) is usually diagnosed in advanced stages of HIV infection when the CD4+ count is <100-200 cells/µl. A 55-year-old woman with HIV/AIDS, well controlled on antiretroviral therapy (ART), CD4+ count in the 300 cells/μl range for >1 year presented with acute onset of headache, nausea and vomiting. She had been on her current ART regimen consisting of raltegravir, co-formulated emtricitabine/tenofovir and etravirine for three years and had been off Pneumocystis prophylaxis for 10 months (trimethoprim-sulfamethoxazole)...
April 2014: International Journal of STD & AIDS
https://read.qxmd.com/read/23848122/-mercury-concentration-in-breast-milk-of-women-from-northwest-mexico-possible-association-with-diet-tobacco-and-other-maternal-factors
#32
JOURNAL ARTICLE
Ramón Gaxiola-Robles, Tania Zenteno-Savín, Vanessa Labrada-Martagón, Alfredo de Jesús Celis de la Rosa, Baudillo Acosta Vargas, Lía Celina Méndez-Rodríguez
OBJECTIVE: To determine THg levels in milk of women from Northwest Mexico and its potential association with maternal factors such as diet and tobacco smoke. METHOD: The study was performed in 108 milk samples donated by women in Baja California Sur. Data were stratified into three groups of 36 donors by number of pregnancies. General data, smoking, exposure to environmental tobacco smoke and seafood intake were explored. THg levels were measured using atomic absorption spectrophotometry...
May 2013: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://read.qxmd.com/read/23794412/opening-the-black-box-revealing-the-molecular-basis-of-thyroid-hormone-transport
#33
COMMENT
Alexandro J Martagón, Kevin J Philips, Paul Webb
No abstract text is available yet for this article.
July 2013: Endocrinology
https://read.qxmd.com/read/23707886/applying-generalized-linear-models-as-an-explanatory-tool-of-sex-steroids-thyroid-hormones-and-their-relationships-with-environmental-and-physiologic-factors-in-immature-east-pacific-green-sea-turtles-chelonia-mydas
#34
JOURNAL ARTICLE
Vanessa Labrada-Martagón, Lia C Méndez-Rodríguez, Marc Mangel, Tania Zenteno-Savín
Generalized linear models were fitted to evaluate the relationship between 17β-estradiol (E2), testosterone (T) and thyroxine (T4) levels in immature East Pacific green sea turtles (Chelonia mydas) and their body condition, size, mass, blood biochemistry parameters, handling time, year, season and site of capture. According to external (tail size) and morphological (<77.3 straight carapace length) characteristics, 95% of the individuals were juveniles. Hormone levels, assessed on sea turtles subjected to a capture stress protocol, were <34...
September 2013: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://read.qxmd.com/read/23670826/suitability-of-different-pollen-as-alternative-food-for-the-predatory-mite-amblyseius-swirskii-acari-phytoseiidae
#35
JOURNAL ARTICLE
Irina Goleva, Claus P W Zebitz
The predacious mite Amblyseius swirskii Athias-Henriot is used as a biological control agent against various pests in greenhouses. Pollen offered as supplementary food is reported to improve their fast establishment and performance. However, the nutritional suitability of different pollens for A. swirskii is not sufficiently known yet. Pollens of 21 plant species were offered to the mites as exclusive food during preimaginal development. Preimaginal mortality and developmental time have been assessed, followed by a life-table analysis of the emerged adults and a calculation of demographic parameters...
November 2013: Experimental & Applied Acarology
https://read.qxmd.com/read/23500624/oxidative-stress-indicators-and-trace-element-concentrations-in-tissues-of-mako-shark-isurus-oxyrinchus
#36
JOURNAL ARTICLE
Marcela Vélez-Alavez, Vanessa Labrada-Martagón, Lía C Méndez-Rodriguez, Felipe Galván-Magaña, Tania Zenteno-Savín
Liver, kidney and muscle from juvenile mako sharks (Isurus oxyrinchus) were collected in Baja California Sur. Lead (Pb), cadmium (Cd), mercury (Hg) and arsenic (As) concentrations were determined by atomic absorption spectrophotometry. The production of superoxide radical (O2(•-)) was measured as an indicator of reactive oxygen species production; lipid peroxidation (TBARS) and protein carbonyl levels were quantified as indicators of oxidative damage, and the activity of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione-S-transferase (GST) was assessed as indicator of antioxidant defenses...
August 2013: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://read.qxmd.com/read/23087171/thyroid-hormone-receptor-agonists-reduce-serum-cholesterol-independent-of-the-ldl-receptor
#37
JOURNAL ARTICLE
Jean Z Lin, Alexandro J Martagón, Willa A Hsueh, John D Baxter, Jan-Åke Gustafsson, Paul Webb, Kevin J Phillips
The majority of cholesterol reduction therapies, such as the statin drugs, work primarily by inducing the expression of hepatic low-density lipoprotein receptors (LDLRs), rendering these therapeutics only partially effective in animals lacking LDLRs. Although thyroid hormones and their synthetic derivatives, often referred to as thyromimetics, have been clearly shown to reduce serum cholesterol levels, this action has generally been attributed to their ability to increase expression of hepatic LDLRs. Here we show for the first time that the thyroid hormone T(3) and the thyroid hormone receptor-β selective agonists GC-1 and KB2115 are capable of markedly reducing serum cholesterol in mice devoid of functional LDLRs by inducing Cyp7a1 expression and stimulating the conversion and excretion of cholesterol as bile acids...
December 2012: Endocrinology
https://read.qxmd.com/read/22099088/group-a-streptococcus-emm-gene-types-in-pharyngeal-isolates-ontario-canada-2002-2010
#38
JOURNAL ARTICLE
Patrick R Shea, Amy L Ewbank, Javier H Gonzalez-Lugo, Alexandro J Martagon-Rosado, Juan C Martinez-Gutierrez, Hina A Rehman, Monica Serrano-Gonzalez, Nahuel Fittipaldi, Stephen B Beres, Anthony R Flores, Donald E Low, Barbara M Willey, James M Musser
Group A Streptococcus (GAS) is a human-adapted pathogen that causes a variety of diseases, including pharyngitis and invasive infections. GAS strains are categorized by variation in the nucleotide sequence of the gene (emm) that encodes the M protein. To identify the emm types of GAS strains causing pharyngitis in Ontario, Canada, we sequenced the hypervariable region of the emm gene in 4,635 pharyngeal GAS isolates collected during 2002-2010. The most prevalent emm types varied little from year to year. In contrast, fine-scale geographic analysis identified inter-site variability in the most common emm types...
November 2011: Emerging Infectious Diseases
https://read.qxmd.com/read/21383167/distinct-signatures-of-diversifying-selection-revealed-by-genome-analysis-of-respiratory-tract-and-invasive-bacterial-populations
#39
JOURNAL ARTICLE
Patrick R Shea, Stephen B Beres, Anthony R Flores, Amy L Ewbank, Javier H Gonzalez-Lugo, Alexandro J Martagon-Rosado, Juan C Martinez-Gutierrez, Hina A Rehman, Monica Serrano-Gonzalez, Nahuel Fittipaldi, Stephen D Ayers, Paul Webb, Barbara M Willey, Donald E Low, James M Musser
Many pathogens colonize different anatomical sites, but the selective pressures contributing to survival in the diverse niches are poorly understood. Group A Streptococcus (GAS) is a human-adapted bacterium that causes a range of infections. Much effort has been expended to dissect the molecular basis of invasive (sterile-site) infections, but little is known about the genomes of strains causing pharyngitis (streptococcal "sore throat"). Additionally, there is essentially nothing known about the genetic relationships between populations of invasive and pharyngitis strains...
March 22, 2011: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/21377544/oxidative-stress-indicators-and-chemical-contaminants-in-east-pacific-green-turtles-chelonia-mydas-inhabiting-two-foraging-coastal-lagoons-in-the-baja-california-peninsula
#40
JOURNAL ARTICLE
Vanessa Labrada-Martagón, Paola A Tenorio Rodríguez, Lia C Méndez-Rodríguez, Tania Zenteno-Savín
In order to determine the potential effects of contaminants in juveniles of East Pacific green turtle, Chelonia mydas, captured alive, circulating trace metal and organochlorine pesticide concentrations were correlated with body condition, antioxidant enzyme activities and lipid peroxidation levels. Turtles were sampled in Punta Abreojos (PAO) and Bahía Magdalena (BMA). Turtles from PAO showed higher silicon and cadmium concentrations, but lower α-hexachlorocyclohexane, γ-hexachlorocyclohexane, hexachlorobenzene and aldrin concentrations than individuals from BMA...
August 2011: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
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