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Alexandro J Martagón, Omar Yaxmehen Bello-Chavolla, Olimpia Arellano-Campos, Paloma Almeda-Valdés, Geoffrey A Walford, Ivette Cruz-Bautista, Donají V Gómez-Velasco, Roopa Mehta, Liliana Muñoz-Hernández, Magdalena Sevilla-González, Tannia L Viveros-Ruiz, María Luisa Ordoñez-Sánchez, Rosario Rodríguez-Guillen, Jose C Florez, María Teresa Tusié-Luna, Carlos A Aguilar-Salinas
OBJECTIVE: To assess if an ethnic-specific variant (p.E508 K) in the maturity-onset diabetes of the young (MODY) gene hepatocyte nuclear factor-1α ( HNF1A ) found in Mexicans is associated with higher sensitivity to sulfonylureas, as documented in patients with MODY3. RESEARCH DESIGN AND METHODS: We recruited 96 participants (46 variant carriers and 50 age- and sex-matched noncarriers). Response to glipizide (one 2.5-5.0-mg dose), metformin (four 500-mg doses), and an oral glucose challenge was evaluated using a previously validated protocol...
May 29, 2018: Diabetes Care
Omar Yaxmehen Bello-Chavolla, Paloma Almeda-Valdes, Donaji Gomez-Velasco, Tannia Viveros-Ruiz, Ivette Cruz-Bautista, Alonso Romo-Romo, Daniel Sánchez-Lázaro, Dushan Meza-Oviedo, Arsenio Vargas-Vázquez, Olimpia Arellano Campos, Magdalena Del Rocío Sevilla-González, Alexandro J Martagón, Liliana Muñoz Hernández, Roopa Mehta, César Rodolfo Caballeros-Barragán, Carlos A Aguilar-Salinas
OBJECTIVE: We developed a novel non-insulin-based fasting score to evaluate insulin sensitivity validated against the euglycemic-hyperinsulinemic clamp (EHC). We also evaluated its correlation with ectopic fact accumulation and its capacity to predict incident type 2 diabetes mellitus (T2D). DESIGN AND METHODS: The discovery sample was composed by 125 subjects (57 without and 68 with T2D) that underwent an EHC. We defined METS-IR as Ln((2*G0 )+TG0 )*BMI)/(Ln(HDL-c)) (G0 : fasting glucose, TG0 : fasting triglycerides, BMI: body mass index, HDL-c: high-density lipoprotein cholesterol), and compared its diagnostic performance against the M-value adjusted by fat-free mass (MFFM) obtained by an EHC...
May 2018: European Journal of Endocrinology
Xun Gong, Kuo-Hsiang Hung, Yu-Wei Ting, Tsai-Wen Hsu, Lenka Malikova, Huyen Trang Tran, Chao-Li Huang, Shih-Hui Liu, Tzen-Yuh Chiang
Gene flow between species may last a long time in plants. Reticulation inevitably causes difficulties in phylogenetic reconstruction. In this study, we looked into the genetic divergence and phylogeny of 20 Lilium species based on multilocus analyses of 8 genes of chloroplast DNA (cpDNA), the internally transcribed nuclear ribosomal DNA (nrITS) spacer and 20 loci extracted from the expressed sequence tag (EST) libraries of L. longiflorum Thunb. and L. formosanum Wallace. The phylogeny based on the combined data of the maternally inherited cpDNA and nrITS was largely consistent with the taxonomy of Lilium sections...
2017: PloS One
Jan Antonio Lammel-Lindemann, Eduardo Flores-Villalba, Alexandro Jose Martagón, Eduardo DeObeso-Gonzalez, Francisco Puente-Gallegos
Arterial hypertension is a highly manageable disorder due to a variety of drugs available for its treatment. Since the late 1990s, angiotensin II receptor blockers have been widely prescribed, achieving appropriate control in patients' blood pressure. Few cases of serious adverse effects have been reported to date. Here, we present a case of acute hepatocellular injury secondary to candesartan administration. Further studies should be performed in patients who present with this adverse effect, in order to prevent more serious outcomes...
January 2018: British Journal of Clinical Pharmacology
M Urbaniec-Kiepura, A Bach
BACKGROUND: The aim of the present study was to compare different strategies for cryopreservation of martagon lily meristems and to evaluate the physiological status of the regenerants. MATERIALS AND METHODS: The bulblets were stored at 5 degree C or 20 degree C and pretreated with 3% or 6% sucrose prior to droplet-vitrification. The meristems were then assessed for their survival and regeneration. Their photochemical activity was investigated using a Photosynthesis Yield Analyzer MINI PAM 2000 Portable Chlorophyll Fluorometer and their photosynthesis oxygen production was evaluated with a Plant Vital 5030 device...
March 2017: Cryo Letters
Karen A Bjorndal, Alan B Bolten, Milani Chaloupka, Vincent S Saba, Cláudio Bellini, Maria A G Marcovaldi, Armando J B Santos, Luis Felipe Wurdig Bortolon, Anne B Meylan, Peter A Meylan, Jennifer Gray, Robert Hardy, Beth Brost, Michael Bresette, Jonathan C Gorham, Stephen Connett, Barbara Van Sciver Crouchley, Mike Dawson, Deborah Hayes, Carlos E Diez, Robert P van Dam, Sue Willis, Mabel Nava, Kristen M Hart, Michael S Cherkiss, Andrew G Crowder, Clayton Pollock, Zandy Hillis-Starr, Fernando A Muñoz Tenería, Roberto Herrera-Pavón, Vanessa Labrada-Martagón, Armando Lorences, Ana Negrete-Philippe, Margaret M Lamont, Allen M Foley, Rhonda Bailey, Raymond R Carthy, Russell Scarpino, Erin McMichael, Jane A Provancha, Annabelle Brooks, Adriana Jardim, Milagros López-Mendilaharsu, Daniel González-Paredes, Andrés Estrades, Alejandro Fallabrino, Gustavo Martínez-Souza, Gabriela M Vélez-Rubio, Ralf H Boulon, Jaime A Collazo, Robert Wershoven, Vicente Guzmán Hernández, Thomas B Stringell, Amdeep Sanghera, Peter B Richardson, Annette C Broderick, Quinton Phillips, Marta Calosso, John A B Claydon, Tasha L Metz, Amanda L Gordon, Andre M Landry, Donna J Shaver, Janice Blumenthal, Lucy Collyer, Brendan J Godley, Andrew McGowan, Matthew J Witt, Cathi L Campbell, Cynthia J Lagueux, Thomas L Bethel, Lory Kenyon
Somatic growth is an integrated, individual-based response to environmental conditions, especially in ectotherms. Growth dynamics of large, mobile animals are particularly useful as bio-indicators of environmental change at regional scales. We assembled growth rate data from throughout the West Atlantic for green turtles, Chelonia mydas, which are long-lived, highly migratory, primarily herbivorous mega-consumers that may migrate over hundreds to thousands of kilometers. Our dataset, the largest ever compiled for sea turtles, has 9690 growth increments from 30 sites from Bermuda to Uruguay from 1973 to 2015...
November 2017: Global Change Biology
Miriam Rodríguez-González, Laura Kawasaki, Nancy Velázquez-Zavala, Eunice Domínguez-Martín, Abraham Trejo-Medecigo, Natalia Martagón, Emilio Espinoza-Simón, Araceli Vázquez-Ibarra, Laura Ongay-Larios, Dimitris Georgellis, Eulàlia de Nadal, Francesc Posas, Roberto Coria
The Kluyveromyces lactis SLN1 phosphorelay system includes the osmosensor histidine kinase Sln1, the phosphotransfer protein Ypd1 and the response regulator Ssk1. Here we show that K. lactis has a functional phosphorelay system. In vitro assays, using a heterologous histidine kinase, show that the phosphate group is accepted by KlYpd1 and transferred to KlSsk1. Upon hyperosmotic stress the phosphorelay is inactivated, KlYpd1 is dephosphorylated in a KlSln1 dependent manner, and only the version of KlSsk1 that lacks the phosphate group interacts with the MAPKKK KlSsk2...
June 2017: Molecular Microbiology
Patricia Carolina Castillo-Castañeda, Ramón Gaxiola-Robles, Vanessa Labrada-Martagón, Baudilio Acosta Vargas, Lía Celina Méndez-Rodríguez, Tania Zenteno-Savín
INTRODUCTION: Breast milk contains molecules needed for the development of children; the integrity and function of these molecules is affected by the presence of pro-oxidants. Protein carbonyls are mainly produced as a result of the interaction of metals with reactive oxygen species (ROS), which may initiate a chain reaction that promotes molecular oxidation. OBJECTIVE: This study aimed to determine the association between the concentration of protein carbonyls with the concentration of trace elements (lead [Pb], cadmium [Cd] and selenium [Se]), superoxide radical (O2•-) production, and glutathione (GSH) content, as well with the activity of the main antioxidant enzymes (superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GPx], glutathione reductase [GR] and glutathione S-transferase [GST]) in breast milk...
February 1, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Roopa Mehta, Rafael Zubirán, Alexandro J Martagón, Alejandra Vazquez-Cárdenas, Yayoi Segura-Kato, María Teresa Tusié-Luna, Carlos A Aguilar-Salinas
The burden caused by familial hypercholesterolemia (FH) varies among countries and ethnic groups. The prevalence and characteristics of FH in Latin American (LA) countries is largely unknown. We present a systematic review (following the PRISMA statement) of FH in LA countries. The epidemiology, genetics, screening, management, and unique challenges encountered in these countries are discussed. Published reports discussing FH in Hispanic or LA groups was considered for analysis. Thirty studies were included representing 10 countries...
December 2016: Journal of Lipid Research
Patricia Carolina Castillo-Castañeda, Ramón Gaxiola-Robles, Lía Celina Méndez-Rodríguez, Vanessa Labrada-Martagón, Tania Zenteno-Savín
No abstract text is available yet for this article.
March 25, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Jean Z Lin, Alexandro J Martagón, Stephanie L Cimini, Daniel D Gonzalez, David W Tinkey, Amadeo Biter, John D Baxter, Paul Webb, Jan-Åke Gustafsson, Sean M Hartig, Kevin J Phillips
The functional conversion of white adipose tissue (WAT) into a tissue with brown adipose tissue (BAT)-like activity, often referred to as "browning," represents an intriguing strategy for combating obesity and metabolic disease. We demonstrate that thyroid hormone receptor (TR) activation by a synthetic agonist markedly induces a program of adaptive thermogenesis in subcutaneous WAT that coincides with a restoration of cold tolerance to cold-intolerant mice. Distinct from most other browning agents, pharmacological TR activation dissociates the browning of WAT from activation of classical BAT...
November 24, 2015: Cell Reports
Guillermo J Ruiz-Delgado, Jesús Hernández-Reyes, Mónica Patricia González-Ramírez, Nora Ángela Martagón-Herrera, Javier Garcés-Eisele, Alejandro Ruiz-Argüelles, Angélica González-Cortés, Guillermo J Ruiz-Argüelles
Donor-derived malignancies after allogeneic hematopoietic stem cell transplantation and after solid organ transplantation are considered as rare diseases. We have prospectively searched for donor cell leukemia in a 12-year period, in a single institution, in a group of 106 consecutive patients allografted because of leukemia. We have identified seven cases of donor cell leukemia; six were allografted because of relapsed acute lymphoblastic leukemia and one because of paroxysmal nocturnal hemoglobinuria/aplastic anemia...
September 2015: Gaceta Médica de México
Mónica P González-Ramírez, Karla Miravete-Lagunes, Andrés Gómez-de-León, Sergio Ponce-de-León, Andrea P Tenorio-Rojo, Nora A Martagón-Herrera, Jesús A Hernández-Reyes, Arturo García-Villasenor, Esteban Burguette, María Fernanda Vallejo-Villalobos, Guillermo J Ruiz-Delgado, David Gómez-Almaguer, Guillermo J Ruiz-Argüelles
BACKGROUND: Quality of life (QOL) is an important consideration in the counseling, implementation, and post-treatment management of arduous treatments for life-threatening conditions such as allogeneic hematopoietic cell transplantation (allo-HCT). OBJECTIVE: To analyze the QOL of leukemia patients allografted with the Mexican reduced-intensity conditioning regimen in two Mexican academic medical centers. MATERIAL AND METHODS: By means of the quality metric short form 36 version 2 to measure generic health concepts, relevant QOL was analyzed in leukemia patients who underwent allo-HCT using reduced-intensity conditioning on an outpatient basis at either the Centro de Hematología y Medicina Interna de Puebla of the Clínica Ruiz or the Hematology Service of the Internal Medicine Department of the Hospital "Dr...
March 2015: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
Ramón Gaxiola-Robles, Vanessa Labrada-Martagón, Oscar Kurt Bitzer-Quintero, Tania Zenteno-Savín, Lía Celina Méndez-Rodríguez
Purine nucleoside phosphorylase (PNP) is an ubiquitous enzyme which plays an important role in arsenic (As) detoxification. As is a toxic metalloid present in air, soil and water; is abundant in the environment and is readily transferred along the trophic chain, being found even in human breast milk. Milk is the main nutrient source for the growth and development of neonates. Information on breast milk synthesis and its potential defense mechanism against As toxicity is scarce. In this study, PNP and antioxidant enzymes activities, as well as glutathione (GSH) and total arsenic (TAs) concentrations, were quantified in breast milk samples...
May 1, 2015: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Alexandro J Martagón, Jean Z Lin, Stephanie L Cimini, Paul Webb, Kevin J Phillips
Thyroid hormone receptor (TR) agonists have been proposed as therapeutic agents to treat non-alcoholic fatty liver disease (NAFLD) and insulin resistance. We investigated the ability of the TR agonists GC-1 and KB2115 to reduce hepatic steatosis in ob/ob mice. Both compounds markedly reduced hepatic triglyceride levels and ameliorated hepatic steatosis. However, the amelioration of fatty liver was not sufficient to improve insulin sensitivity in these mice and reductions in hepatic triglycerides did not correlate with improvements in insulin sensitivity or glycemic control...
2015: PloS One
Gabriela Zamora-Ortiz, Sara Velázquez-Sánchez-de-Cima, Jesus Hernández-Reyes, Nora Angela Martagón-Herrera, Alejandro Ruiz-Argüelles, Guillermo J Ruiz-Delgado, Guillermo J Ruiz-Argüelles
BACKGROUND: The gold standard for paraproteinemia screening in plasma cell disorders has been serum protein electro- phoresis (SPE) with immunofixation electrophoresis (IFx); serum total and free light chain quantifications have also been used. OBJECTIVE: To define the role of SPE, IFx and serum total light chain (sLC) determinations in patients with multiple myeloma (MM), both at diagnosis and at maximum response during treatment follow-up. MATERIAL AND METHODS: These serological studies were performed in a group of 62 patients with MM at diagnosis, and in a subset of 29 patients at the point of maximum response to treatment...
July 2014: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
M Urbaniec-Kiepura, A Bach
BACKGROUND: The aim of the study was to compare different strategies for the cryopreservation of Lilium martagon L. seeds. MATERIALS AND METHODS: The starting material was seeds of the martagon lily (without or with a special pretreatment involving sucrose pre-culture dehydratation and desiccation) subjected to cryopreservation after preliminary storage under conventional conditions (-5 degree C, 5 degree C, or 15 degree C). The effects of storage, pretreatment and cryopreservation on the seeds were assessed in terms of seed germination and phenotypic changes in the seedlings derived from those seeds...
November 2014: Cryo Letters
Ramón Gaxiola-Robles, Vanessa Labrada-Martagón, Alfredo de Jesús Celis de la Rosa, Baudilio Acosta-Vargas, Lía Celina Méndez-Rodríguez, Tania Zenteno-Savín
Breast milk is regarded as an ideal source of nutrients for the growth and development of neonates, but it can also be a potential source of pollutants. Mothers can be exposed to different contaminants as a result of their lifestyle and environmental pollution. Mercury (Hg) and arsenic (As) could adversely affect the development of fetal and neonatal nervous system. Some fish and shellfish are rich in selenium (Se), an essential trace element that forms part of several enzymes related to the detoxification process, including glutathione S-transferase (GST)...
2014: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Jesús Hernández-Reyes, Mónica Patricia González-Ramírez, Nora Ángela Martagón-Herrera, Alan Daniel Rosales-Durón, Guillermo J Ruiz-Delgado, Guillermo J Ruiz-Argüelles
BACKGROUND: Paroxysmal nocturnal hemoglobinuria (PNH) stems from chronic, complement-mediated, intravascular hemolysis, which results in anemia, hemoglobinuria, fatigue, and other hemolysis-related disabling symptoms. Novel diagnostic methods have led into an increased identification of the disease. AIMS: To analyze the salient features of patients with PNH identified in a single institution in México, in a 30-year period. MATERIAL AND METHODS: The records of 31 patients with PNH identified between 1984 and 2013 were reviewed; 20 females...
January 2014: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
Sara Velázquez-Sánchez-de-Cima, Gabriela Zamora-Ortiz, Jesús Hernández-Reyes, Alan Daniel Rosales-Durón, Mónica Patricia González-Ramírez, Nora Angela Martagón-Herrera, Guillermo J Ruiz-Delgado, Guillermo J Ruiz-Argüelles
BACKGROUND: In 2003, oral fludarabine was introduced in the USA for the treatment of patients with hematologic malignancies as an alternative to its intravenous (i.v.) formulation; in 2008, it was introduced in México while the i.v. formulation was withdrawn. Accordingly, i.v. fludarabine had to be replaced by oral fludarabine as part of the conditioning regimen employed to conduct allogeneic stem cell transplantation in México. METHODS: Nonrandomized retrospective analysis of 55 patients conditioned with oral fludarabine compared with 113 patients conditioned with the i...
2014: Acta Haematologica
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