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Patricia Carolina Castillo-Castañeda, Ramón Gaxiola-Robles, Lía Celina Méndez-Rodríguez, Vanessa Labrada-Martagón, Tania Zenteno-Savín
Introducción: los plaguicidas organoclorados (POC) pueden incrementar la producción de especies reactivas de oxígeno (ERO). Tales efectos pueden ser contrarrestados por el sistema antioxidante, el cual se encuentra también en la leche materna. Objetivo: evaluar los indicadores de estrés oxidativo en leche materna asociados a la presencia de POC y su relación con la ingesta de alimentos marinos. Métodos: la leche materna fue colectada de 108 mujeres lactantes. Los indicadores de estrés oxidativo (actividad enzimática antioxidante, concentración de glutatión, producción de radical superóxido [O 2•- ], concentración de peroxidación de lípidos y carbonilos proteicos) se analizaron por espectrofotometría...
2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Jean Z Lin, Alexandro J Martagón, Stephanie L Cimini, Daniel D Gonzalez, David W Tinkey, Amadeo Biter, John D Baxter, Paul Webb, Jan-Åke Gustafsson, Sean M Hartig, Kevin J Phillips
The functional conversion of white adipose tissue (WAT) into a tissue with brown adipose tissue (BAT)-like activity, often referred to as "browning," represents an intriguing strategy for combating obesity and metabolic disease. We demonstrate that thyroid hormone receptor (TR) activation by a synthetic agonist markedly induces a program of adaptive thermogenesis in subcutaneous WAT that coincides with a restoration of cold tolerance to cold-intolerant mice. Distinct from most other browning agents, pharmacological TR activation dissociates the browning of WAT from activation of classical BAT...
November 24, 2015: Cell Reports
Guillermo J Ruiz-Delgado, Jesús Hernández-Reyes, Mónica Patricia González-Ramírez, Nora Ángela Martagón-Herrera, Javier Garcés-Eisele, Alejandro Ruiz-Argüelles, Angélica González-Cortés, Guillermo J Ruiz-Argüelles
Donor-derived malignancies after allogeneic hematopoietic stem cell transplantation and after solid organ transplantation are considered as rare diseases. We have prospectively searched for donor cell leukemia in a 12-year period, in a single institution, in a group of 106 consecutive patients allografted because of leukemia. We have identified seven cases of donor cell leukemia; six were allografted because of relapsed acute lymphoblastic leukemia and one because of paroxysmal nocturnal hemoglobinuria/aplastic anemia...
September 2015: Gaceta Médica de México
Mónica P González-Ramírez, Karla Miravete-Lagunes, Andrés Gómez-de-León, Sergio Ponce-de-León, Andrea P Tenorio-Rojo, Nora A Martagón-Herrera, Jesús A Hernández-Reyes, Arturo García-Villasenor, Esteban Burguette, María Fernanda Vallejo-Villalobos, Guillermo J Ruiz-Delgado, David Gómez-Almaguer, Guillermo J Ruiz-Argüelles
BACKGROUND: Quality of life (QOL) is an important consideration in the counseling, implementation, and post-treatment management of arduous treatments for life-threatening conditions such as allogeneic hematopoietic cell transplantation (allo-HCT). OBJECTIVE: To analyze the QOL of leukemia patients allografted with the Mexican reduced-intensity conditioning regimen in two Mexican academic medical centers. MATERIAL AND METHODS: By means of the quality metric short form 36 version 2 to measure generic health concepts, relevant QOL was analyzed in leukemia patients who underwent allo-HCT using reduced-intensity conditioning on an outpatient basis at either the Centro de Hematología y Medicina Interna de Puebla of the Clínica Ruiz or the Hematology Service of the Internal Medicine Department of the Hospital "Dr...
March 2015: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
Ramón Gaxiola-Robles, Vanessa Labrada-Martagón, Oscar Kurt Bitzer-Quintero, Tania Zenteno-Savín, Lía Celina Méndez-Rodríguez
Purine nucleoside phosphorylase (PNP) is an ubiquitous enzyme which plays an important role in arsenic (As) detoxification. As is a toxic metalloid present in air, soil and water; is abundant in the environment and is readily transferred along the trophic chain, being found even in human breast milk. Milk is the main nutrient source for the growth and development of neonates. Information on breast milk synthesis and its potential defense mechanism against As toxicity is scarce. In this study, PNP and antioxidant enzymes activities, as well as glutathione (GSH) and total arsenic (TAs) concentrations, were quantified in breast milk samples...
2015: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Alexandro J Martagón, Jean Z Lin, Stephanie L Cimini, Paul Webb, Kevin J Phillips
Thyroid hormone receptor (TR) agonists have been proposed as therapeutic agents to treat non-alcoholic fatty liver disease (NAFLD) and insulin resistance. We investigated the ability of the TR agonists GC-1 and KB2115 to reduce hepatic steatosis in ob/ob mice. Both compounds markedly reduced hepatic triglyceride levels and ameliorated hepatic steatosis. However, the amelioration of fatty liver was not sufficient to improve insulin sensitivity in these mice and reductions in hepatic triglycerides did not correlate with improvements in insulin sensitivity or glycemic control...
2015: PloS One
Gabriela Zamora-Ortiz, Sara Velázquez-Sánchez-de-Cima, Jesus Hernández-Reyes, Nora Angela Martagón-Herrera, Alejandro Ruiz-Argüelles, Guillermo J Ruiz-Delgado, Guillermo J Ruiz-Argüelles
BACKGROUND: The gold standard for paraproteinemia screening in plasma cell disorders has been serum protein electro- phoresis (SPE) with immunofixation electrophoresis (IFx); serum total and free light chain quantifications have also been used. OBJECTIVE: To define the role of SPE, IFx and serum total light chain (sLC) determinations in patients with multiple myeloma (MM), both at diagnosis and at maximum response during treatment follow-up. MATERIAL AND METHODS: These serological studies were performed in a group of 62 patients with MM at diagnosis, and in a subset of 29 patients at the point of maximum response to treatment...
July 2014: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
M Urbaniec-Kiepura, A Bach
BACKGROUND: The aim of the study was to compare different strategies for the cryopreservation of Lilium martagon L. seeds. MATERIALS AND METHODS: The starting material was seeds of the martagon lily (without or with a special pretreatment involving sucrose pre-culture dehydratation and desiccation) subjected to cryopreservation after preliminary storage under conventional conditions (-5 degree C, 5 degree C, or 15 degree C). The effects of storage, pretreatment and cryopreservation on the seeds were assessed in terms of seed germination and phenotypic changes in the seedlings derived from those seeds...
November 2014: Cryo Letters
Ramón Gaxiola-Robles, Vanessa Labrada-Martagón, Alfredo de Jesús Celis de la Rosa, Baudilio Acosta-Vargas, Lía Celina Méndez-Rodríguez, Tania Zenteno-Savín
Breast milk is regarded as an ideal source of nutrients for the growth and development of neonates, but it can also be a potential source of pollutants. Mothers can be exposed to different contaminants as a result of their lifestyle and environmental pollution. Mercury (Hg) and arsenic (As) could adversely affect the development of fetal and neonatal nervous system. Some fish and shellfish are rich in selenium (Se), an essential trace element that forms part of several enzymes related to the detoxification process, including glutathione S-transferase (GST)...
2014: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Jesús Hernández-Reyes, Mónica Patricia González-Ramírez, Nora Ángela Martagón-Herrera, Alan Daniel Rosales-Durón, Guillermo J Ruiz-Delgado, Guillermo J Ruiz-Argüelles
BACKGROUND: Paroxysmal nocturnal hemoglobinuria (PNH) stems from chronic, complement-mediated, intravascular hemolysis, which results in anemia, hemoglobinuria, fatigue, and other hemolysis-related disabling symptoms. Novel diagnostic methods have led into an increased identification of the disease. AIMS: To analyze the salient features of patients with PNH identified in a single institution in México, in a 30-year period. MATERIAL AND METHODS: The records of 31 patients with PNH identified between 1984 and 2013 were reviewed; 20 females...
January 2014: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
Sara Velázquez-Sánchez-de-Cima, Gabriela Zamora-Ortiz, Jesús Hernández-Reyes, Alan Daniel Rosales-Durón, Mónica Patricia González-Ramírez, Nora Angela Martagón-Herrera, Guillermo J Ruiz-Delgado, Guillermo J Ruiz-Argüelles
BACKGROUND: In 2003, oral fludarabine was introduced in the USA for the treatment of patients with hematologic malignancies as an alternative to its intravenous (i.v.) formulation; in 2008, it was introduced in México while the i.v. formulation was withdrawn. Accordingly, i.v. fludarabine had to be replaced by oral fludarabine as part of the conditioning regimen employed to conduct allogeneic stem cell transplantation in México. METHODS: Nonrandomized retrospective analysis of 55 patients conditioned with oral fludarabine compared with 113 patients conditioned with the i...
2014: Acta Haematologica
Ramón Gaxiola-Robles, Oscar Kurt Bitzer-Quintero, Lía Celina Méndez-Rodríguez, Vanessa Labrada-Martagón, Adolfo García-González, Luis Javier Ramírez-Jirano, Marcela Veléz-Alavez, Tania Zenteno-Savín
INTRODUCTION: Diabetes is associated with increased lipid peroxidation, quantified as the levels of thiobarbituric acid reactive substances (TBARS). In parallel, the antioxidant defense system (ADS) reacts to diminish the oxidative damage. OBJECTIVE: To determine the levels of lipid peroxidation and the activity of antioxidant enzymes in obese type 2 diabetic (DM2) individuals compared to non-obese DM2 individuals. METHODS: Lipid peroxidation was quantified by measuring TBARS and the ADS response by measuring the activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)...
November 2013: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Yun-peng Du, Chi Wei, Zhong-xuan Wang, Shuang Li, Heng-bin He, Gui-xia Jia
Recent molecular and karyologic studies have significantly modified delimitation of Lilium. However, despite the importance of pollen evolution in the genus comprehensive studies with electron microscopy and evaluation of pollen evolution are lacking. Therefore, we studied pollen morphology in a sample of 65 individuals from 37 taxa covering all the sections distributed in the world, using scanning electron microscopy. Our collection of 49 individuals from 21 taxa covering all five sections in China was also included in the database...
2014: PloS One
Yun-peng Du, Heng-bin He, Zhong-xuan Wang, Shuang Li, Chi Wei, Xiao-na Yuan, Qi Cui, Gui-xia Jia
We present a comprehensive phylogeny derived from nuclear ribosomal DNA (nrDNA) for 214 samples representing 98 species and five varieties, including 44 species and five varieties native to China. Our collection of 25 species and five varieties (44 samples) covering all five sections of the genus (Comber) distributed in China also were included in the internal transcribed spacer (ITS) database. This study incorporates previous research with an emphasis on Chinese species, including the controversial subsection, Sinomartagon 5c Comber...
March 2014: Journal of Plant Research
Auras R Atreya, Sonali Arora, Vijay T Gadiraju, José Martagon-Villamil, Daniel J Skiest
Toxoplasma encephalitis (TE) is usually diagnosed in advanced stages of HIV infection when the CD4+ count is <100-200 cells/µl. A 55-year-old woman with HIV/AIDS, well controlled on antiretroviral therapy (ART), CD4+ count in the 300 cells/μl range for >1 year presented with acute onset of headache, nausea and vomiting. She had been on her current ART regimen consisting of raltegravir, co-formulated emtricitabine/tenofovir and etravirine for three years and had been off Pneumocystis prophylaxis for 10 months (trimethoprim-sulfamethoxazole)...
April 2014: International Journal of STD & AIDS
Ramón Gaxiola-Robles, Tania Zenteno-Savín, Vanessa Labrada-Martagón, Alfredo de Jesús Celis de la Rosa, Baudillo Acosta Vargas, Lía Celina Méndez-Rodríguez
OBJECTIVE: To determine THg levels in milk of women from Northwest Mexico and its potential association with maternal factors such as diet and tobacco smoke. METHOD: The study was performed in 108 milk samples donated by women in Baja California Sur. Data were stratified into three groups of 36 donors by number of pregnancies. General data, smoking, exposure to environmental tobacco smoke and seafood intake were explored. THg levels were measured using atomic absorption spectrophotometry...
May 2013: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Alexandro J Martagón, Kevin J Philips, Paul Webb
No abstract text is available yet for this article.
July 2013: Endocrinology
Vanessa Labrada-Martagón, Lia C Méndez-Rodríguez, Marc Mangel, Tania Zenteno-Savín
Generalized linear models were fitted to evaluate the relationship between 17β-estradiol (E2), testosterone (T) and thyroxine (T4) levels in immature East Pacific green sea turtles (Chelonia mydas) and their body condition, size, mass, blood biochemistry parameters, handling time, year, season and site of capture. According to external (tail size) and morphological (<77.3 straight carapace length) characteristics, 95% of the individuals were juveniles. Hormone levels, assessed on sea turtles subjected to a capture stress protocol, were <34...
September 2013: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
Irina Goleva, Claus P W Zebitz
The predacious mite Amblyseius swirskii Athias-Henriot is used as a biological control agent against various pests in greenhouses. Pollen offered as supplementary food is reported to improve their fast establishment and performance. However, the nutritional suitability of different pollens for A. swirskii is not sufficiently known yet. Pollens of 21 plant species were offered to the mites as exclusive food during preimaginal development. Preimaginal mortality and developmental time have been assessed, followed by a life-table analysis of the emerged adults and a calculation of demographic parameters...
November 2013: Experimental & Applied Acarology
Marcela Vélez-Alavez, Vanessa Labrada-Martagón, Lía C Méndez-Rodriguez, Felipe Galván-Magaña, Tania Zenteno-Savín
Liver, kidney and muscle from juvenile mako sharks (Isurus oxyrinchus) were collected in Baja California Sur. Lead (Pb), cadmium (Cd), mercury (Hg) and arsenic (As) concentrations were determined by atomic absorption spectrophotometry. The production of superoxide radical (O2(•-)) was measured as an indicator of reactive oxygen species production; lipid peroxidation (TBARS) and protein carbonyl levels were quantified as indicators of oxidative damage, and the activity of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione-S-transferase (GST) was assessed as indicator of antioxidant defenses...
August 2013: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
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