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https://www.readbyqxmd.com/read/29049359/analysis-of-pd-1-expression-in-the-monocyte-subsets-from-non-septic-and-septic-preterm-neonates
#1
Magdalena Zasada, Marzena Lenart, Magdalena Rutkowska-Zapała, Małgorzata Stec, Wojciech Durlak, Andrzej Grudzień, Agnieszka Krzeczkowska, Nina Mól, Marta Pilch, Maciej Siedlar, Przemko Kwinta
Programmed death-1 (PD-1) receptor system represents a part of recently reported immunoregulatory pathway. PD-1 is an immune checkpoint molecule, which plays an important role in downregulating the immune system proinflammatory activity. Until recently, PD-1 expression was not established on immune cells of the preterm infants. The study objectives were to confirm expression of the PD-1 receptors on the monocytes isolated from very low birth weight newborns (VLBW), and to analyze their expression during the first week of life and late-onset sepsis...
2017: PloS One
https://www.readbyqxmd.com/read/29046116/impact-of-human-milk-banking-on-neonatal-mortality-necrotizing-enterocolitis-and-exclusive-breastfeeding-experience-from-a-tertiary-care-teaching-hospital-south-india
#2
B Adhisivam, Vishnu Bhat, N Banupriya, Rachel Poorna, Nishad Plakkal, C Palanivel
OBJECTIVE: To study the impact of a Human Milk Bank (HMB) on neonatal mortality, incidence of necrotizing enterocolitis (NEC) and rate of exclusive breastfeeding. METHODS: This pre-post intervention study was conducted in a tertiary care teaching institute in south India. Data regarding neonatal mortality, incidence of NEC and exclusive breastfeeding rates were collected for a period of 6 months before and after establishing a modern HMB and compared. RESULTS: The number of deliveries, live births and incidence of preterm and VLBW neonates during pre- and post-HMB periods were comparable...
October 18, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29031388/postnatal-rbc-arachidonic-and-docosahexaenoic-acids-deficiencies-are-associated-with-higher-risk-of-neonatal-morbidities-and-mortality-in-preterm-infants
#3
S Fares, M M Sethom, M B Hammami, M Cheour, M Feki, S Hadj-Taieb, S Kacem
Arachidonic (AA) and docosahexaenoic (DHA) acids are essential for the health and development of the neonate. Red blood cell (RBC) fatty acids were analyzed in 583 very low birth weight (VLBW) infants and 274 term infants using capillary gas chromatography. VLBW infants exhibited significantly lower RBC AA (13.0 ± 0.89 vs. 13.5 ± 0.98) and DHA (3.77 ± 0.60 vs. 3.80 ± 0.62), but higher n6:n3 ratio (3.97 ± 0.46 vs. 3.63 ± 0.37) than term infants. In VLBW infants, DHA was lower in those born with small for gestational age (3...
November 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29030727/-parenteral-nutrition-in-premature-babies-with-a-birth-weight-1500g-a%C3%A2-systematic-single-center-analysis-and-comparison-with-current-guidelines
#4
Melanie Sirch, Martin Poryo, Mona Butte, Ulrike Lindner, Ludwig Gortner, Michael Zemlin, Holger Nunold, Sascha Meyer
BACKGROUND: Parenteral and enteral nutrition are essential for both growth and development of preterm infants. Based on the results of many studies, the rate of nutritional growth and the amount of substrate delivered parenterally are under debate. OBJECTIVE: The main aim of this study was to assess parenteral nutrition in very and extremely immature preterm infants, i.e. very low birth weight (VLBW, birth weight <1500g) and extremely low birth weight (ELBW, birth weight <1000g) neonates, and to compare the amount of parenterally delivered substrate in our neonatal intensive care unit (NICU) to current German guidelines...
October 13, 2017: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28968426/neuroimaging-of-decoding-and-language-comprehension-in-young-very-low-birth-weight-vlbw-adolescents-indications-for-compensatory-mechanisms
#5
Helene van Ettinger-Veenstra, Carin Widén, Maria Engström, Thomas Karlsson, Ingemar Leijon, Nina Nelson
In preterm children with very low birth weight (VLBW ≤ 1500 g), reading problems are often observed. Reading comprehension is dependent on word decoding and language comprehension. We investigated neural activation-within brain regions important for reading-related to components of reading comprehension in young VLBW adolescents in direct comparison to normal birth weight (NBW) term-born peers, with the use of functional magnetic resonance imaging (fMRI). We hypothesized that the decoding mechanisms will be affected by VLBW, and expect to see increased neural activity for VLBW which may be modulated by task performance and cognitive ability...
2017: PloS One
https://www.readbyqxmd.com/read/28960518/high-sensitivity-c-reactive-protein-concentration-in-young-adults-in-the-helsinki-study-of-very-low-birth-weight-adults
#6
Kai Yin Ho, Rie Goto, Pieta Näsänen-Gilmore, Sture Andersson, Johan G Eriksson, Eero Kajantie, Petteri Hovi
Low birth weight and chronic low-grade inflammation have been significantly associated with an increased risk of cardiovascular disease (CVD) (1,2). C-reactive protein (CRP) is a highly sensitive biomarker that is used to detect the inflammation associated with predictive factors related to CVD, such as atherogenesis or atherosclerosis (3). Adults born preterm at a very low birth weight (VLBW) of less than 1,500g represent the low end of the low birth weight spectrum and have increased levels of CVD risk factors (4)...
September 28, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28943321/a-randomized-pilot-study-comparing-the-role-of-peep-o2-flow-and-high-flow-air-for-weaning-of-ventilatory-support-in-very-low-birth-weight-infants
#7
Chang-Yo Yang, Mei-Chin Yang, Shih-Ming Chu, Ming-Chou Chiang, Reyin Lien
BACKGROUND: There is a lack of evidence to guide step-wise weaning of positive pressure respiratory support for premature infants. This study sought to compare the efficacy of three weaning protocols we designed to facilitate weaning of very low birth weight (VLBW, less than 1500 g) preterm infants from nasal continuous positive airway pressure (NCPAP) support. METHODS: This was a prospective, randomized, controlled trial of VLBW preterm infants who received positive pressure ventilatory support in our neonatal intensive care unit (NICU) from April 2008 through March 2009...
September 6, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28936899/morbidity-and-mortality-of-very-low-birth-weight-multiples-compared-with-singletons
#8
Roser Porta, Eva Capdevila, Francesc Botet, Sergi Verd, Gemma Ginovart, Elisenda Moliner, Marta Nicolàs, Jose Rios
BACKGROUND: Previous studies comparing the neonatal outcome of very low birth weight (VLBW) multiples and singletons have suggested a worse outcome for multiples at gestational ages on the limits of viability. OBJECTIVES: The objective of this study is to determine the neonatal mortality and morbidity of VLBW multiples compared to singletons. METHODS: This is a retrospective study including all infants registered in the Spanish network for infants under 1500 g (SEN1500), over a 12-year period (from 2002 to 2013)...
September 22, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28919598/risk-factors-and-immediate-outcome-of-very-low-birth-weight-babies-appropriate-for-gestational-age-in-newly-established-scanu-mymensingh-medical-college-hospital
#9
K Begum, M N Islam, M A Hossain, M A Ali, M K Islam, M A Islam, M Salim, M Oliullah
Low birth weight (LBW) is the most important preventable cause in the neonatal period leading to very high neonatal mortality and morbidity in developing countries like Bangladesh. A cross sectional study was conducted in the neonatology ward, Mymensingh Medical College Hospital, Mymensingh from July 2014 to December 2014 to identify the risk factors and immediate hospital outcome of Very Low Birth Weight (VLBW) Appropriate for Gestational Age (AGA) babies in context of present neonatal hospital care standard...
July 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28916575/effects-of-probiotics-on-necrotizing-enterocolitis-sepsis-intraventricular-hemorrhage-mortality-length-of-hospital-stay-and-weight-gain-in-very-preterm-infants-a-meta-analysis
#10
REVIEW
Jing Sun, Gayatri Marwah, Matthew Westgarth, Nicholas Buys, David Ellwood, Peter H Gray
Probiotics are increasingly used as a supplement to prevent adverse health outcomes in preterm infants. We conducted a systematic review, meta-analysis, and subgroup analysis of findings from randomized controlled trials (RCTs) to assess the magnitude of the effect of the probiotics on health outcomes among very-low-birth-weight (VLBW) infants. Relevant articles from January 2003 to June 2017 were selected from a broad range of databases, including Medline, PubMed, Scopus, and Embase. Studies were included if they used an RCT design, involved a VLBW infant (birthweight <1500 g or gestational age <32 wk) population, included a probiotic intervention group, measured necrotizing enterocolitis (NEC) as a primary outcome, and measured sepsis, mortality, length of hospital stay, weight gain, and intraventricular hemorrhage (IVH) as additional outcomes...
September 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28901786/effect-of-gestational-age-on-the-epidemiology-of-late-onset-sepsis-in-neonatal-intensive-care-units-a-review
#11
Elsa Da Palma Afonso, Stijn Blot
Neonatal sepsis is a major cause of morbidity and mortality. Late-onset sepsis affects a significant percentage of infants admitted to the neonatal intensive care unit (NICU). Most affected newborns are preterm or low birth weight, but late-onset sepsis also affects late preterm and term infants. Understanding how gestational age affects the epidemiology of late-onset sepsis can be of use when defining strategies for its prevention and clinical management in NICU. Areas covered: Available evidence suggests the incidence and mortality of late-onset sepsis is higher in preterm and VLBW infants, but pathogen distribution and risk exposure is similar across all infants admitted to NICU...
September 25, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28898404/high-versus-standard-volume-enteral-feeds-to-promote-growth-in-preterm-or-low-birth-weight-infants
#12
REVIEW
Thangaraj Abiramalatha, Niranjan Thomas, Vijay Gupta, Anand Viswanathan, William McGuire
BACKGROUND: Breast milk alone, given at standard recommended volumes (150 to 180 mL/kg/d), is not adequate to meet the protein, energy, and other nutrient requirements of growing preterm or low birth weight infants. One strategy that may be used to address these potential nutrient deficits is to give infants enteral feeds in excess of 200 mL/kg/d ('high-volume' feeds). This approach may increase nutrient uptake and growth rates, but concerns include that high-volume enteral feeds may cause feed intolerance, gastro-oesophageal reflux, aspiration pneumonia, necrotising enterocolitis, or complications related to fluid overload, including patent ductus arteriosus and bronchopulmonary dysplasia...
September 12, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28866004/neurodevelopmental-outcomes-of-infants-with-very-low-birth-weights-are-associated-with-the-severity-of-their-extra-uterine-growth-retardation
#13
Han-Chun Chien, Chao-Huei Chen, Teh-Ming Wang, Ya-Chi Hsu, Ming-Chih Lin
BACKGROUND: For infants with very low birth weights (VLBW), their neurodevelopmental outcomes are thought to be associated with extra-uterine growth retardation (EUGR). In this study, based on a single institute, we analyzed the association between different levels or severity of EUGR of VLBW infants and their neurodevelopmental outcomes later at a corrected age of 24 months. METHODS: This is a hospital-based retrospective cohort study. The severity of EUGR was classified into three categories according to the z-score of discharge weight: z < -2...
August 11, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28854319/slow-advancement-of-enteral-feed-volumes-to-prevent-necrotising-enterocolitis-in-very-low-birth-weight-infants
#14
REVIEW
Sam J Oddie, Lauren Young, William McGuire
BACKGROUND: Early enteral feeding practices are potentially modifiable risk factors for necrotising enterocolitis (NEC) in very preterm or very low birth weight (VLBW) infants. Observational studies suggest that conservative feeding regimens, including slowly advancing enteral feed volumes, reduce the risk of NEC. However, slow feed advancement may delay establishment of full enteral feeding and may be associated with metabolic and infectious morbidities secondary to prolonged exposure to parenteral nutrition...
August 30, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28826265/role-of-delayed-cord-clamping-in-prevention-of-necrotizing-enterocolitis-in-preterm-neonates-a-systematic-review
#15
Bhawan Deep Garg, Anju Bansal
BACKGROUND: Necrotizing enterocolitis (NEC) is one of the leading causes of neonatal mortality and morbidity particularly in very-low-birth-weight (VLBW) neonates. The incidence of NEC varies across countries and neonatal centers in between 7-14%. AIMS: To evaluate the role of delayed cord clamping (DCC) for prevention of NEC in preterm neonates. METHOD: The literature search was done for various randomized control trial (RCT) by searching the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, EMBASE, ongoing clinical trials and abstract of conferences...
August 21, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28812000/diagnostic-imaging-features-of-necrotizing-enterocolitis-a-narrative-review
#16
REVIEW
Francesco Esposito, Rosanna Mamone, Marco Di Serafino, Carmela Mercogliano, Valerio Vitale, Gianfranco Vallone, Patrizia Oresta
Necrotizing enterocolitis (NEC) is an inflammatory process, characterized by intestinal necrosis of variable extension, leading to perforation, generalized peritonitis and death. The classical pathogenetic theory focuses on mucosal damage related to a stress induced intestinal ischemia leading to mucosal injury and bacterial colonization of the wall. A more recent hypothesis emphasizes the role of immaturity of gastrointestinal and immune system, particularly of the premature, responsible of bowel wall vulnerability and suffering...
June 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28811156/screening-of-congenital-hypothyroidism-in-preterm-low-birth-weight-and-very-low-birth-weight-neonates-a-systematic-review
#17
REVIEW
Mahin Hashemipour, Silva Hovsepian, Arman Ansari, Mojtaba Keikha, Pooyan Khalighinejad, Negar Niknam
Evidence from different screening programs indicated that the rate of congenital hypothyroidism (CH) was higher in pre-term and low-birth-weight (LBW) newborns than normal ones. Incomplete development of hypothalamic-pituitary axis in this group of neonates results in the delayed rise of TSH and missing cases with CH. Hence, there is a great need for a practicable systematic screening method for proper diagnosis of CH in this group of neonates. In this review, we systematically reviewed papers with the following key words ([Congenital Hypothyroidism AND Screening AND Thyroxine AND Thyroid Stimulating Hormone AND Low Birth Weight AND Premature]) in international electronic databases including PubMed, Scopus, and Google Scholar...
July 22, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28802067/crh-stimulation-tests-for-the-infants-with-relative-adrenal-insufficiency
#18
Kougoro Iwanaga, Akane Yamamoto, Takashi Matsukura, Fusako Niwa, Masahiko Kawai
BACKGROUND: Very low birth weight (VLBW) infants are considered to be vulnerable to relative adrenal insufficiency (RAI); however, diagnosis is difficult in some clinical settings. Considering this background, it is necessary to establish a diagnosis of RAI in preterm infants. OBJECTIVE: In this study, we attempted to clarify the difference in response to CRH stimulation tests for preterm infants with or without RAI. METHODS: Between June 2009 and December 2015, we performed CRH stimulation tests for preterm infants born at a gestational age of <30 weeks at around two weeks of age...
August 12, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28798147/very-preterm-birth-and-parents-quality-of-life-27-years-later
#19
Dieter Wolke, Nicole Baumann, Barbara Busch, Peter Bartmann
BACKGROUND AND OBJECTIVES: Parents of preterm children experience increased distress early in their children's lives. Whether the quality of life of parents of preterm children is comparable to that of parents of term children by the time their offspring reach adulthood is unknown. What precursors in their offspring's childhood predict parental quality of life? METHODS: A prospective whole-population study in Germany followed very preterm (VP) (<32 weeks gestation) or very low birth weight (VLBW) (<1500 g) (N = 250) and term-born individuals (N = 230) and their parents (VP or VLBW: N = 219; term: N = 227) from birth to adulthood...
September 2017: Pediatrics
https://www.readbyqxmd.com/read/28796851/association-of-maternal-preeclampsia-with-infant-risk-of-premature-birth-and-retinopathy-of-prematurity
#20
Julia P Shulman, Cindy Weng, Jacob Wilkes, Tom Greene, M Elizabeth Hartnett
Importance: Studies report conflicting associations between preeclampsia and retinopathy of prematurity (ROP). This study provides explanations for the discrepancies to clarify the relationship between preeclampsia and ROP. Objective: To evaluate the association of maternal preeclampsia and risk of ROP among infants in an unrestricted birth cohort and a restricted subcohort of preterm, very low birth weight (P-VLBW) infants. Design, Setting, and Participants: A retrospective review of 290 992 live births within the Intermountain Healthcare System in Utah from January 1, 2001, through December 31, 2010, was performed...
September 1, 2017: JAMA Ophthalmology
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