keyword
https://read.qxmd.com/read/29886065/clinical-study-of-presepsin-and-pentraxin3-in-critically-ill-children
#21
JOURNAL ARTICLE
Fady M El Gendy, Muhammad S El-Mekkawy, Nagwan Y Saleh, Mona Salah El-Din Habib, Faten Ezzelarab Younis
PURPOSE: To assess the value of Presepsin and Pentraxin3 measurement in critically ill children. MATERIALS AND METHODS: Prospective observational study conducted on 80 children admitted into Pediatric Intensive Care Unit (PICU) and 80 healthy controls. Patients were evaluated for presence of sepsis. Pediatric Risk of Mortality (PRISM) and Pediatric Index of Mortality (PIM2) were calculated. Serum Presepsin and Pentraxin3 were measured within 24 h of admission...
October 2018: Journal of Critical Care
https://read.qxmd.com/read/29681053/diagnostic-value-of-plasma-pentraxin3-level-for-diagnosis-of-erectile-dysfunction
#22
JOURNAL ARTICLE
Ali Erhan Eren, Ahmet Reit Ersay, Emrah Demirci, Cabir Alan, Gökhan Basturk
PURPOSE: Erectile dysfunction (ED) is a sexual dysfunction described as the inability to develop or maintain an erection of the penis adequate for sexual intercourse, and its prevalence increases with age. Seen as a common sexual disorder worldwide, organic causes are the underlying reason for 80 percent of ED cases, with the most characteristic pathology responsible for organic ED being atherosclerosis. This study investigates the diagnostic value of plasma PTX-3 levels in arterial ED...
July 10, 2018: Urology Journal
https://read.qxmd.com/read/28739185/novel-atherogenic-pathways-from-the-differential-transcriptome-analysis-of-diabetic-epicardial-adipose-tissue
#23
COMPARATIVE STUDY
V Camarena, D Sant, M Mohseni, T Salerno, M L Zaleski, G Wang, G Iacobellis
BACKGROUND AND AIM: To evaluate the epicardial adipose tissue (EAT) transcriptome in comparison to subcutaneous fat (SAT) in coronary artery disease (CAD) and type 2 diabetes (T2DM). METHODS AND RESULTS: SAT and EAT samples were obtained from subjects with T2DM and CAD (n = 5) and those without CAD with or without T2DM (=3) undergoing elective cardiac surgery. RNA-sequencing analysis was performed in both EAT and SAT. Gene enrichment analysis was conducted to identify pathways affected by the differentially expressed genes...
August 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://read.qxmd.com/read/28523566/radial-glia-cells-control-angiogenesis-in-the-developing-cerebral-cortex-through-tgf-%C3%AE-1-signaling
#24
JOURNAL ARTICLE
Michele Siqueira, Daniel Francis, Diego Gisbert, Flávia Carvalho Alcantara Gomes, Joice Stipursky
Neuroangiogenesis in the developing central nervous system is controlled by interactions between endothelial cells (ECs) and radial glia (RG) neural stem cells, although RG-derived molecules implicated in these events are not fully known. Here, we investigated the role of RG-secreted TGF-β1, in angiogenesis in the developing cerebral cortex. By isolation of murine microcapillary brain endothelial cells (MBECs), we demonstrate that conditioned medium from RG cultures (RG-CM) promoted MBEC migration and formation of vessel-like structures in vitro, in a TGF-β1-dependent manner...
May 2018: Molecular Neurobiology
https://read.qxmd.com/read/28377558/pentraxin-3-as-a-new-indicator-of-cardiovascular%C3%A2-related-death-in-patients-with-advanced-chronic-kidney-disease
#25
JOURNAL ARTICLE
Marcin Krzanowski, Katarzyna Krzanowska, Mariusz Gajda, Paulina Dumnicka, Artur Dziewierz, Karolina Woziwodzka, Jan A Litwin, Władysław Sułowicz
INTRODUCTION    Pentraxin3 (PTX3) play an important role in the inflammatory response, taking part in recognizing pathogens and damaged tissues. OBJECTIVES    The aim of the study was to assess the relationship between PTX3 levels and all-cause and cardiovascular (CV) mortality in chronic kidney disease (CKD) patients during five-year observation period.  PATIENTS AND METHODS    The study comprised 78 patients (51 hemodialyzed, 27 predialysis). The examined parameters included PTX3, calcium, phosphate, iPTH, interleukin-6 (IL-6), fibroblast growth factor 23 (FGF-23), osteopontin (OPN), osteoprotegerin (OPG), osteocalcin (OC), osteopontin (OPN), osteoprotegerin (OPG), osteocalcin, tumor necrosis factor receptor II (TNF-R II), transforming growth factor-β (TGF-β), hepatocyte growth factor (HGF), stromal cell-derived factor α (SDF1α), and thrombomodulin (TM)...
February 27, 2017: Polish Archives of Internal Medicine
https://read.qxmd.com/read/28267132/pentraxin3-as-a-new-indicator-of-cardiovascular-related-death-in-patients-with-advanced-chronic-kidney-disease
#26
JOURNAL ARTICLE
Marcin Krzanowski, Katarzyna Krzanowska, Mariusz Gajda, Paulina Dumnicka, Artur Dziewierz, Karolina Woziwodzka, Jan A Litwin, Władysław Sułowicz
INTRODUCTION    Pentraxin3 (PTX3) play an important role in the inflammatory response, taking part in recognizing pathogens and damaged tissues. OBJECTIVES    The aim of the study was to assess the relationship between PTX3 levels and all-cause and cardiovascular (CV) mortality in chronic kidney disease (CKD) patients during five-year observation period.  PATIENTS AND METHODS    The study comprised 78 patients (51 hemodialyzed, 27 predialysis). The examined parameters included PTX3, calcium, phosphate, iPTH, interleukin-6 (IL-6), fibroblast growth factor 23 (FGF-23), osteopontin (OPN), osteoprotegerin (OPG), osteocalcin (OC), osteopontin (OPN), osteoprotegerin (OPG), osteocalcin, tumor necrosis factor receptor II (TNF-R II), transforming growth factor-β (TGF-β), hepatocyte growth factor (HGF), stromal cell-derived factor α (SDF1α), and thrombomodulin (TM)...
February 27, 2017: Polish Archives of Internal Medicine
https://read.qxmd.com/read/27935854/second-trimester-maternal-serum-markers-in-the-prediction-of-preeclampsia
#27
JOURNAL ARTICLE
Qiong Luo, Xiujun Han
AIM: To determine whether late second-trimester maternal serum biomarkers are useful for the prediction of preeclampsia during the third trimester, a case-control study including 33 preeclamptic and 71 healthy pregnancies was conducted. Maternal serum concentrations of placental protein 13 (PP13), pregnancy-associated plasma protein (PAPP-A), pentraxin3 (PTX3), soluble FMS-like tyrosine kinase-1 (sFlt-1), myostatin and follistatin-like-3 (FSLT-3) were measured at 24-28 weeks' gestation...
October 26, 2017: Journal of Perinatal Medicine
https://read.qxmd.com/read/27889356/role-of-ptx3-in-corneal-epithelial-innate-immunity-against-aspergillus-fumigatus-infection
#28
JOURNAL ARTICLE
Jie Zhang, Guiqiu Zhao, Jing Lin, Chengye Che, Cui Li, Nan Jiang, Liting Hu, Qian Wang
Pentraxin3 (PTX3), a member of long pentraxin family, plays a non-redundant role in human humoral innate immunity. However, whether PTX3 is expressed by corneal epithelial cells and its role during corneal fungi infection has not yet been investigated. To identify the presence of PTX3 in cornea, the possible mechanisms involved in its expression, and also the effects on corneal anti-fungi innate immune response, clinic human corneal tissues and cultured human corneal epithelial cells (HCECs) were resorted. PTX3 mRNA and protein were detected in corneal samples and cultured HCECs, which was significantly up-regulated after exposing to Aspergillus fumigatus (A...
February 2018: Experimental Eye Research
https://read.qxmd.com/read/27775787/ptx3-expression-in-the-plasma-of-elderly-aci-patients-and-its-relationship-with-severity-and-prognosis-of-the-disease
#29
JOURNAL ARTICLE
L-Z Qin, W Li, Y Huang, F Lu, S-J Li, H-Q Yang, J-W Zhang
OBJECTIVE: This study aims to investigate the expression of pentraxin3 (PTX3) in elderly patients with acute cerebral infarction (ACI) and to analyze the relationship of PTX3 with the severity and prognosis of ACI. PATIENTS AND METHODS: Between June 2014 and August 2015, 96 elderly patients with first-onset of ACI admitted to our institution were enrolled in the present study. Also, 70 healthy elderly subjects were included as controls in this study. Levels of PTX3, C-reactive protein (CRP), tumor necrosis factor (TNF)-α, homocysteine (Hcy), fibrinogen (FIB), total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were determined in all patients both pre-therapeutically and 30 days post-therapeutically...
October 2016: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/27661853/fibrocytes-and-fibrovascular-membrane-formation-in-proliferative-diabetic-retinopathy
#30
JOURNAL ARTICLE
Kazunori Tamaki, Ayumi Usui-Ouchi, Akira Murakami, Nobuyuki Ebihara
Purpose: The purpose of this study was to investigate whether fibrocytes participate in formation of the fibrovascular membrane (FVM) in patients with proliferative diabetic retinopathy (PDR). Methods: Vitreous fluid and FVM samples were obtained during vitrectomy in patients with PDR. Samples from patients with macular hole or epiretinal membrane were used as controls. Vitreous fluid and FVM samples were subjected to immunohistochemical analysis. In addition, cells isolated from the vitreous fluid of PDR and control patients were cultured in serum-free medium...
September 1, 2016: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/27538101/association-of-genetic-variants-in-pentraxin-3-gene-with-ankylosing-spondylitis
#31
JOURNAL ARTICLE
Xu Zhang, Wenyuan Ding
BACKGROUND Pentraxin 3 is considered to play an important role in immune and inflammatory reaction. This study aimed to detect the effect of pentraxin3 gene (PTX3) polymorphisms on ankylosing spondylitis (AS) risk. MATERIAL AND METHODS The genotyping of PTX3 polymorphisms in 101 AS patients and 93 controls was conducted by allelic discrimination assay and the genotype distribution was assessed for Hardy-Weinberg equilibrium (HWE). The differences of genotype, allele, haplotype, and some basic indexes were compared by χ2 test...
August 18, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/26892644/association-between-microglia-inflammatory-factors-and-complement-with-loss-of-hippocampal-mossy-fiber-synapses-induced-by-trimethyltin
#32
JOURNAL ARTICLE
Andrew D Kraft, Christopher A McPherson, G Jean Harry
Complement-associated factors are implicated in pathogen presentation, neurodegeneration, and microglia resolution of tissue injury. To characterize complement activation with microglial clearance of degenerating mossy fiber boutons, hippocampal dentate granule neurons were ablated in CD-1 mice with trimethyltin (TMT; 2.2 mg/kg, i.p.). Neuronal apoptosis was accompanied by amoeboid microglia and elevations in tumor necrosis factor [Tnfa], interleukin 1β [Il1b], and Il6 mRNA and C1q protein. Inos mRNA levels were unaltered...
July 2016: Neurotoxicity Research
https://read.qxmd.com/read/26859579/circulating-inflammatory-mediators-as-potential-prognostic-markers-of-human-colorectal-cancer
#33
JOURNAL ARTICLE
Giuseppe Di Caro, Michele Carvello, Samantha Pesce, Marco Erreni, Federica Marchesi, Jelena Todoric, Matteo Sacchi, Marco Montorsi, Paola Allavena, Antonino Spinelli
BACKGROUND: Cytokines and chemokines in the tumor microenvironment drive metastatic development and their serum levels might mirror the ongoing inflammatory reaction at the tumor site. Novel highly sensitive tools are needed to identify colorectal cancer patients at high risk of recurrence that should be more closely monitored during post-surgical follow up. Here we study whether circulating inflammatory markers might be used to predict recurrence in CRC patients. METHODS: Circulating levels of the inflammatory cytokines IL-1, IL-6, IL-10, TNFalpha, CCL2, CXCL8, VEGF and the acute phase protein Pentraxin-3 were measured by ELISA in preoperative serum samples prospectively collected from a cohort of sixty-nine patients undergoing surgical resection for stage 0-IV CRC and associated with post-operative disease recurrence...
2016: PloS One
https://read.qxmd.com/read/26673442/plasma-pentraxin3-level-is-associated-with-plaque-vulnerability-assessed-by-optical-coherence-tomography-in-patients-with-coronary-artery-disease
#34
JOURNAL ARTICLE
Ryunosuke Tazaki, Jun Tanigawa, Tomohiro Fujisaka, Kensaku Shibata, Yoshihiro Takeda, Tadashi Ishihara, Masaaki Hoshiga, Toshiaki Hanafusa, Nobukazu Ishizaka
The role of pentraxin 3 (PTX3) has been implicated in the process of plaque vulnerability. However, few studies have addressed the direct relationship between plaque morphology and plasma PTX3. We evaluated the relationship between coronary vulnerable plaque, assessed by optical coherence tomography (OCT), and plasma PTX3 in patients with coronary artery disease (CAD).OCT was used to determine plaque vulnerability in 51 patients with non-ST segment elevation acute coronary syndrome (NSTE-ACS; n = 17) and stable angina (SA; n = 34)...
2016: International Heart Journal
https://read.qxmd.com/read/26644796/tnf-up-regulates-pentraxin3-expression-in-human-airway-smooth-muscle-cells-via-jnk-and-erk1-2-mapk-pathways
#35
JOURNAL ARTICLE
Jingbo Zhang, Latifa Koussih, Lianyu Shan, Andrew J Halayko, Ben-Kuen Chen, Abdelilah S Gounni
BACKGROUND: Long pentraxin 3 (PTX3) is a novel candidate marker for inflammation in many chronic diseases. As a soluble pattern recognition receptor, PTX3 is involved in amplification of inflammatory reactions and regulation of innate immunity. Previously, we demonstrate that human airway smooth muscle cells (HASMC) express constitutively PTX3 and upon TNF stimulation. However, very little is known about the mechanism governing its expression in HASMC. We sought to investigate the mechanism governing TNF induced PTX3 expression in primary HASMC...
2015: Allergy, Asthma, and Clinical Immunology
https://read.qxmd.com/read/26578407/the-immunoproteasome-controls-the-availability-of-the-cardioprotective-pattern-recognition-molecule-pentraxin3
#36
JOURNAL ARTICLE
Anna Paeschke, Anna Possehl, Karin Klingel, Martin Voss, Karolin Voss, Meike Kespohl, Martina Sauter, Hermen S Overkleeft, Nadine Althof, Cecilia Garlanda, Antje Voigt
Cardiomyocyte death as a result of viral infection is an excellent model for dissecting the inflammatory stress response that occurs in heart tissue. We reported earlier that a specific proteasome isoform, the immunoproteasome, prevents exacerbation of coxsackievirus B3 (CVB3)-induced myocardial destruction and preserves cell vitality in heart tissue inflammation. Following the aim to decipher molecular targets of immunoproteasome-dependent proteolysis, we investigated the function and regulation of the soluble PRR Pentraxin3 (PTX3)...
March 2016: European Journal of Immunology
https://read.qxmd.com/read/26162942/the-association-of-circulating-inflammatory-and-oxidative-stress-biomarker-levels-with-diagonal-earlobe-crease-in-patients-with-atherosclerotic-diseases
#37
JOURNAL ARTICLE
Takashi Koyama, Hiroyuki Watanabe, Hiroshi Ito
BACKGROUND: Earlobe creases (ELC) are frequently observed in patients with atherosclerosis. Atherosclerosis is considered to be a systemic vascular inflammatory disease, and oxidative stress is known to be a contributor to vascular inflammation. It is well known that inflammatory biomarkers [high-sensitivity C-reactive protein (hs-CRP), pentraxin3 (PTX3)] and oxidative stress markers [malondialdehyde low-density lipoprotein (MDA-LDL)] are associated with atherosclerotic changes. This study was designed to test the hypothesis that biomarkers of inflammation and oxidative stress are increased in patients with ELC...
April 2016: Journal of Cardiology
https://read.qxmd.com/read/26056957/increment-of-pentraxin3-expression-in-abdominal-aortic-aneurysm
#38
LETTER
Hisashi Sawada, Yoshiro Naito, Makiko Oboshi, Yuko Soyama, Koichi Nishimura, Akiyo Eguchi, Tomotaka Ando, Yoshitaka Okuhara, Daisuke Morisawa, Toshihiro Iwasaku, Shinichi Hirotani, Toshiaki Mano, Masataka Mitsuno, Yuji Miyamoto, Tohru Masuyama
No abstract text is available yet for this article.
September 15, 2015: International Journal of Cardiology
https://read.qxmd.com/read/25989910/novel-inflammatory-markers-in-hyperlipidemia-clinical-implications
#39
REVIEW
Angeliki Papapanagiotou, Gerasimos Siasos, Eva Kassi, Antonios N Gargalionis, Athanasios G Papavassiliou
Hyperlipidemia is characterized by abnormally increased plasma of any or all lipids and /or lipoproteins and is a confirmed risk factor for the formation of atherosclerosis. Inflammation plays a crucial role in the formation and progression of atherosclerosis and consequently on cardiovascular diseases. Nowadays, the effective role of the immune system and subsequently of systemic inflammation is well established. Multiple levels of evidence from experimental models and histopathologic assessment of tissues to systemic biomarkers and epidemiologic or clinical associations have revealed that inflammation is one of the basic mechanisms in the destabilization of the atherogenetic plaque which leads to clinical events...
2015: Current Medicinal Chemistry
https://read.qxmd.com/read/25962566/biological-actions-of-pentraxins
#40
REVIEW
Gemma Vilahur, Lina Badimon
The innate immunity is the first defense reaction against microorganisms or altered self-components upon tissue injury. Such exogenous or modified endogenous molecules present conserved molecular structures that are recognized by the immune system via pattern-recognition receptors or molecules. Within the soluble pattern-recognition molecules pentraxins play an important role in humoral innate immunity. Pentraxins branch off into the short and long pentraxins. Short constituents include C-reactive protein (CRP) and serum amyloid P-component which are synthesized in the liver mostly upon IL-6 stimulation...
October 2015: Vascular Pharmacology
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