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Kazunori Tamaki, Ayumi Usui-Ouchi, Akira Murakami, Nobuyuki Ebihara
Purpose: The purpose of this study was to investigate whether fibrocytes participate in formation of the fibrovascular membrane (FVM) in patients with proliferative diabetic retinopathy (PDR). Methods: Vitreous fluid and FVM samples were obtained during vitrectomy in patients with PDR. Samples from patients with macular hole or epiretinal membrane were used as controls. Vitreous fluid and FVM samples were subjected to immunohistochemical analysis. In addition, cells isolated from the vitreous fluid of PDR and control patients were cultured in serum-free medium...
September 1, 2016: Investigative Ophthalmology & Visual Science
Xu Zhang, Wenyuan Ding
BACKGROUND Pentraxin 3 is considered to play an important role in immune and inflammatory reaction. This study aimed to detect the effect of pentraxin3 gene (PTX3) polymorphisms on ankylosing spondylitis (AS) risk. MATERIAL AND METHODS The genotyping of PTX3 polymorphisms in 101 AS patients and 93 controls was conducted by allelic discrimination assay and the genotype distribution was assessed for Hardy-Weinberg equilibrium (HWE). The differences of genotype, allele, haplotype, and some basic indexes were compared by χ2 test...
2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Andrew D Kraft, Christopher A McPherson, G Jean Harry
Complement-associated factors are implicated in pathogen presentation, neurodegeneration, and microglia resolution of tissue injury. To characterize complement activation with microglial clearance of degenerating mossy fiber boutons, hippocampal dentate granule neurons were ablated in CD-1 mice with trimethyltin (TMT; 2.2 mg/kg, i.p.). Neuronal apoptosis was accompanied by amoeboid microglia and elevations in tumor necrosis factor [Tnfa], interleukin 1β [Il1b], and Il6 mRNA and C1q protein. Inos mRNA levels were unaltered...
July 2016: Neurotoxicity Research
Giuseppe Di Caro, Michele Carvello, Samantha Pesce, Marco Erreni, Federica Marchesi, Jelena Todoric, Matteo Sacchi, Marco Montorsi, Paola Allavena, Antonino Spinelli
BACKGROUND: Cytokines and chemokines in the tumor microenvironment drive metastatic development and their serum levels might mirror the ongoing inflammatory reaction at the tumor site. Novel highly sensitive tools are needed to identify colorectal cancer patients at high risk of recurrence that should be more closely monitored during post-surgical follow up. Here we study whether circulating inflammatory markers might be used to predict recurrence in CRC patients. METHODS: Circulating levels of the inflammatory cytokines IL-1, IL-6, IL-10, TNFalpha, CCL2, CXCL8, VEGF and the acute phase protein Pentraxin-3 were measured by ELISA in preoperative serum samples prospectively collected from a cohort of sixty-nine patients undergoing surgical resection for stage 0-IV CRC and associated with post-operative disease recurrence...
2016: PloS One
Ryunosuke Tazaki, Jun Tanigawa, Tomohiro Fujisaka, Kensaku Shibata, Yoshihiro Takeda, Tadashi Ishihara, Masaaki Hoshiga, Toshiaki Hanafusa, Nobukazu Ishizaka
The role of pentraxin 3 (PTX3) has been implicated in the process of plaque vulnerability. However, few studies have addressed the direct relationship between plaque morphology and plasma PTX3. We evaluated the relationship between coronary vulnerable plaque, assessed by optical coherence tomography (OCT), and plasma PTX3 in patients with coronary artery disease (CAD).OCT was used to determine plaque vulnerability in 51 patients with non-ST segment elevation acute coronary syndrome (NSTE-ACS; n = 17) and stable angina (SA; n = 34)...
2016: International Heart Journal
Jingbo Zhang, Latifa Koussih, Lianyu Shan, Andrew J Halayko, Ben-Kuen Chen, Abdelilah S Gounni
BACKGROUND: Long pentraxin 3 (PTX3) is a novel candidate marker for inflammation in many chronic diseases. As a soluble pattern recognition receptor, PTX3 is involved in amplification of inflammatory reactions and regulation of innate immunity. Previously, we demonstrate that human airway smooth muscle cells (HASMC) express constitutively PTX3 and upon TNF stimulation. However, very little is known about the mechanism governing its expression in HASMC. We sought to investigate the mechanism governing TNF induced PTX3 expression in primary HASMC...
2015: Allergy, Asthma, and Clinical Immunology
Anna Paeschke, Anna Possehl, Karin Klingel, Martin Voss, Karolin Voss, Meike Kespohl, Martina Sauter, Hermen S Overkleeft, Nadine Althof, Cecilia Garlanda, Antje Voigt
Cardiomyocyte death as a result of viral infection is an excellent model for dissecting the inflammatory stress response that occurs in heart tissue. We reported earlier that a specific proteasome isoform, the immunoproteasome, prevents exacerbation of coxsackievirus B3 (CVB3)-induced myocardial destruction and preserves cell vitality in heart tissue inflammation. Following the aim to decipher molecular targets of immunoproteasome-dependent proteolysis, we investigated the function and regulation of the soluble PRR Pentraxin3 (PTX3)...
March 2016: European Journal of Immunology
Takashi Koyama, Hiroyuki Watanabe, Hiroshi Ito
BACKGROUND: Earlobe creases (ELC) are frequently observed in patients with atherosclerosis. Atherosclerosis is considered to be a systemic vascular inflammatory disease, and oxidative stress is known to be a contributor to vascular inflammation. It is well known that inflammatory biomarkers [high-sensitivity C-reactive protein (hs-CRP), pentraxin3 (PTX3)] and oxidative stress markers [malondialdehyde low-density lipoprotein (MDA-LDL)] are associated with atherosclerotic changes. This study was designed to test the hypothesis that biomarkers of inflammation and oxidative stress are increased in patients with ELC...
April 2016: Journal of Cardiology
Hisashi Sawada, Yoshiro Naito, Makiko Oboshi, Yuko Soyama, Koichi Nishimura, Akiyo Eguchi, Tomotaka Ando, Yoshitaka Okuhara, Daisuke Morisawa, Toshihiro Iwasaku, Shinichi Hirotani, Toshiaki Mano, Masataka Mitsuno, Yuji Miyamoto, Tohru Masuyama
No abstract text is available yet for this article.
September 15, 2015: International Journal of Cardiology
Angeliki Papapanagiotou, Gerasimos Siasos, Eva Kassi, Antonios N Gargalionis, Athanasios G Papavassiliou
Hyperlipidemia is characterized by abnormally increased plasma of any or all lipids and /or lipoproteins and is a confirmed risk factor for the formation of atherosclerosis. Inflammation plays a crucial role in the formation and progression of atherosclerosis and consequently on cardiovascular diseases. Nowadays, the effective role of the immune system and subsequently of systemic inflammation is well established. Multiple levels of evidence from experimental models and histopathologic assessment of tissues to systemic biomarkers and epidemiologic or clinical associations have revealed that inflammation is one of the basic mechanisms in the destabilization of the atherogenetic plaque which leads to clinical events...
2015: Current Medicinal Chemistry
Gemma Vilahur, Lina Badimon
The innate immunity is the first defense reaction against microorganisms or altered self-components upon tissue injury. Such exogenous or modified endogenous molecules present conserved molecular structures that are recognized by the immune system via pattern-recognition receptors or molecules. Within the soluble pattern-recognition molecules pentraxins play an important role in humoral innate immunity. Pentraxins branch off into the short and long pentraxins. Short constituents include C-reactive protein (CRP) and serum amyloid P-component which are synthesized in the liver mostly upon IL-6 stimulation...
October 2015: Vascular Pharmacology
Jung Kee Min, Jaehong Kim, Je Moon Woo
No abstract text is available yet for this article.
June 2016: Ocular Immunology and Inflammation
Rongqing Sun, Kai Wang, Feifei Li, Hongfu Yang, Xiaoge Sun
OBJECTIVE: To evaluate prognostic value of pentraxin3 ( PTX3 ) content combining with extravascular lung water index ( EVLWI ) in patients with sepsis. METHODS: A retrospective analysis of complete clinical data of septic patients admitted to Department of Critical Care Medicine of the First Affiliated Hospital of Zhengzhou University from February 2013 to February 2014 was conducted. These patients were divided into two groups, survival group and death group, according to the outcome on the 28th day...
January 2015: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
S Uysal, F M Yılmaz, K Karatoprak, F Artüz, N U Cumbul
OBJECTIVE: The objective of this study was to evaluate the relationship between disease severity and biochemical parameters such as pentraxin3, CRP, fetuin-A, insulin and HOMA-IR levels in patients with psoriasis. PATIENTS AND METHODS: This study included 58 patients with psoriasis and 30 healthy controls admitted to Ankara Numune Teaching and Research Hospital between January 2011-August 2012. Serum pentraxin3, CRP, fetuin-A and insulin concentrations were determined...
November 2014: European Review for Medical and Pharmacological Sciences
Yusuke Kobukai, Takashi Koyama, Hiroyuki Watanabe, Hiroshi Ito
This study investigated morning levels of pentraxin3 (PTX3) as a sensitive biomarker for acute inflammation in patients with obstructive sleep apnea (OSA). A total of 61 consecutive patients with OSA were divided into two groups: non-to-mild (n = 20) and moderate-to-severe (n = 41) OSA based on their apnea-hypopnea index (AHI) score. Those patients with moderate-to-severe OSA were further divided into continuous positive airway pressure (CPAP) treated (n = 21) and non-CPAP-treated (n = 20) groups. Morning and evening serum PTX3 and high-sensitivity (hs) C-reactive protein (CRP) levels were measured before and after 3 mo of CPAP therapy...
November 15, 2014: Journal of Applied Physiology
Weishuo Liu, Jianwei Jiang, Dan Yan, Dujuan Li, Wei Li, Yungui Ma, Lili Yang, Zhiling Qu, Qiurong Ruan
BACKGROUND: The objective of this study was to determine the effects of pentraxin3 (PTX3) on human oxidized low density lipoprotein (oxLDL) uptake and cholesterol efflux from human macrophage foam cells, which may play a critical role in atherogenesis. METHODS: The effects of PTX3 on oxLDL uptake and cholesterol efflux were determined after transfection of human THP-1 macrophages with pSG5hPTX3 or PTX3siRNA plasmids. To evaluate the role of specific signaling pathways, human THP-1 cells were pre-treated with inhibitors of the extracellular signal-regulated protein kinases 1 and 2 (ERK1/2), phosphatidylinositide 3-kinases (PI3-K), and p38 mitogen-activated protein kinase (MAPK) pathways (PD98059, LY294002, and SB203580, respectively), and then exposed to oxLDL for the uptake assay or oxLDL and [(3)H]-cholesterol and apolipoprotein A-I (apoA-I) for the cholesterol efflux assay...
June 2014: Experimental and Molecular Pathology
Jung Kee Min, Jaehong Kim, Je Moon Woo
PURPOSE: To evaluate pentraxin3 (PTX3) levels in patients with neovascular age-related macular degeneration (N-ARMD) and to investigate its role as a predictive biomarker. METHODS: Thirty individuals with N-ARMD and 30 controls without N-ARMD were studied. Plasma concentrations of C-reactive protein (CRP) and PTX3 were measured in frozen samples using an enzyme-linked immunosorbent assay kit. RESULTS: PTX3 concentration was 1341 ± 625 pg/mL (mean ± standard deviation) in N-ARMD patients, which was significantly higher than in control subjects (887 ± 478, p = 0...
June 2015: Ocular Immunology and Inflammation
Mitsuaki Isobe
Takayasu arteritis (TA) is a rare nonspecific inflammatory disease of unknown cause, predominantly affecting the aorta and its main branches, coronary arteries, and pulmonary arteries of young females. It induces a variety of nonspecific inflammatory symptoms and ischemic symptoms due to stenotic lesions. Further progression of TA causes destruction of the arterial wall media, leading to aortic regurgitation and aneurysms or rupture of the involved arteries. Although serological tests specific for TA are not available, new better biomarkers are emerging such as pentraxin3 and matrix metalloproteinases...
September 20, 2013: International Journal of Cardiology
Naoto Katakami, Hideaki Kaneto, Fumie Sakamoto, Mitsuyoshi Takahara, Yoko Irie, Keiko Fujisawa, Kazuyuki Miyashita, Tetsuyuki Yasuda, Taka-aki Matsuoka, Kazutomi Yoshiuchi, Ken'ya Sakamoto, Akio Kuroda, Munehide Matsuhisa, Keisuke Kosugi, Iichiro Shimomura
AIMS: Pentraxin3 (PTX3), a recently discovered inflammatory mediator, is produced abundantly in various cells in atherosclerotic lesions, and therefore, its plasma level could reflect local inflammation at the site of atherosclerotic lesion. The present study evaluated whether plasma PTX3 levels are associated with subclinical atherosclerosis in young subjects with type 1 diabetes. METHODS: Plasma PTX3 levels, urinary albumin excretion, diabetic retinopathy, and carotid intima-media thickness (IMT) were examined in 78 Japanese type 1 diabetic patients (30 men and 48 women, aged 28...
February 2013: Diabetes Research and Clinical Practice
Takashi Ishihara, Go Haraguchi, Daisuke Tezuka, Tetsuo Kamiishi, Hiroshi Inagaki, Mitsuaki Isobe
BACKGROUND: Patients with Takayasu arteritis (TA) often show recurrence under steroid treatment without an elevation of C-reactive protein (CRP). There is a report that matrix metalloproteinase (MMP)-2, MMP-3, MMP-9 and pentraxin3 (PTX3) could be sensitive biomarkers, but the characteristics of these biomarkers have not been established. METHODS AND RESULTS: We enrolled 45 consecutive patients; 28 were grouped in an active phase as evidenced by clinical recurrence within 2 years of blood sampling...
2013: Circulation Journal: Official Journal of the Japanese Circulation Society
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