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https://www.readbyqxmd.com/read/29161780/assessment-of-relationship-of-abo-blood-groups-among-tobacco-induced-oral-cancer-patients-of-kanpur-population-uttar-pradesh
#1
Gayathri Ramesh, Anuradha Katiyar, Amrita Raj, Amit Kumar, Ramesh Nagarajappa, Amit Pandey
Background: The possibility of association between ABO blood groups and malignancy was first discussed by Anderson DE & Haas C. The association between blood group and oral cancer is least explored and hence this study was undertaken to evaluate relationship of ABO blood groups with an increased risk for oral cancer. Materials and method: The present study was conducted at various cancer hospitals in Kanpur. The study samples comprised 100 oral cancer patients and 50 controls with tobacco chewing habit...
November 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29161773/silodosin-for-the-treatment-of-lower-urinary-tract-symptoms-in-men-with-benign-prostatic-hyperplasia
#2
REVIEW
Jae Hung Jung, Jiye Kim, Roderick MacDonald, Balaji Reddy, Myung Ha Kim, Philipp Dahm
BACKGROUND: A variety of alpha-blockers are used for treating lower urinary tract symptoms (LUTS) in men with benign prostatic hyperplasia (BPH). Silodosin is a novel, more selective alpha-blocker, which is specific to the lower urinary tract and may have fewer side effects than other alpha-blockers. OBJECTIVES: To assess the effects of silodosin for the treatment of LUTS in men with BPH. SEARCH METHODS: We performed a comprehensive search using multiple databases (Cochrane Library, MEDLINE, EMBASE, Scopus, Google Scholar, and Web of Science), trials registries, other sources of grey literature, and conference proceedings with no restrictions on the language of publication or publication status up until 13 June 2017...
November 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29161769/influence-of-biceps-brachii-tendon-mechanical-properties-on-elbow-flexor-force-steadiness-in-young-and-old-males
#3
Rowan R Smart, Stéphane Baudry, Andrey Fedorov, Samantha L Kuzyk, Jennifer M Jakobi
Elbow flexor force steadiness (FS) depends on strength and decreases with age. Achilles tendon mechanics effect standing balance and isometric plantarflexion FS. This study investigated the influence of distal biceps brachii (BB) tendon mechanics and elbow flexor strength on age-related decline in FS. Nine young (23±2 years) and 9 old (77±5 years) males performed submaximal isometric elbow flexion tasks at low (2.5, 5, 10% maximal voluntary contraction (MVC)) and high (20, 40, 60, 80%MVC) forces in a neutral forearm position...
November 21, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29161752/prenatal-megacystis-is-prediction-of-outcome-and-renal%C3%A2-function-possible
#4
Regina Tschannen, Rita Gobet, Josef Wisser
Objective To assess prenatal prognostic criteria for fetuses with megacystis in order to counsel parents. Methods In a retrospective observational study at a single tertiary referral center, we assessed the clinical course of 53 fetuses with megacystis cared for at the Department of Obstetrics of the University Hospital Zurich between 1995 and 2008 and followed them up for 2 to 12 years. We determined fetal karyotype, amniotic fluid volume and fetal urinary biochemistry as prenatal prognostic factors...
November 21, 2017: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/29161697/age-period-cohort-modeling-of-multiple-sclerosis-incidence-rates-in-kuwait-1980-2014
#5
Saeed Akhtar, Jarrah Al-Abkal, Jasem Y Al-Hashel, Raed Alroughani
BACKGROUND: Multiple sclerosis (MS) is a complex immune-mediated disorder of the central nervous system with undefined etiology. Genetic predisposition and environmental factors play an imperative role in MS causation and its sustained increasing burden worldwide. This study examined the age, period, and cohort effects on MS incidence rates in Kuwait. METHODS: In this retrospective cohort study, data on MS cases diagnosed between January 1, 1980 and December 31, 2014 and registered in National MS Registry and reference population were obtained...
November 21, 2017: Neuroepidemiology
https://www.readbyqxmd.com/read/29161682/socioeconomic-status-disparities-in-late-life-disability-based-on-age-period-and-cohort-in-japan
#6
Hidehiro Sugisawa, Ken Harada, Yoko Sugihara, Shizuko Yanagisawa, Masaya Shinmei
INTRODUCTION: Effects of disparities in socioeconomic status (SES) on late-life disabilities have been reported around the world. However, there are only a few studies that have examined age, period, and cohort dependent influences of SES disparities on late-life disabilities. We investigated associations between SES disparities and late-life disability based on the Age-Period-Cohort. We also investigated how macro-economic conditions unique to a period, or a cohort might explain the period or the cohort trends...
November 14, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29161668/patterns-of-c-reactive-protein-ratio-response-to-antibiotics-in-pediatric-sepsis-a-prospective-cohort-study
#7
Vanessa Soares Lanziotti, Pedro Póvoa, Arnaldo Prata-Barbosa, Lucas Berbet Pulcheri, Ligia S C F Rabello, José Roberto Lapa E Silva, Marcio Soares, Jorge I F Salluh
PURPOSE: Evaluate sequential C-reactive protein (CRP) measurements and patterns of CRP-ratio response to antibiotic therapy during first 7days in Pediatric Intensive Care Unit (PICU) of septic children. METHODS: Prospective, cohort study of children (1month-12years) admitted at 3 PICUs, with diagnosis of sepsis with <72h course. CRP-ratio was calculated in relation to D0_CRP value. Children were classified according to an individual pattern of CRP-ratio response: fast - CRP_D4 of therapy was <0...
November 11, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29161655/the-association-between-ambient-temperature-and-mortality-in-south-africa-a-time-series-analysis
#8
Noah Scovronick, Francesco Sera, Fiorella Acquaotta, Diego Garzena, Simona Fratianni, Caradee Y Wright, Antonio Gasparrini
BACKGROUND: There is an extensive literature describing temperature-mortality associations in developed regions, but research from developing countries, and Africa in particular, is limited. METHODS: We conducted a time-series analysis using daily temperature data and a national dataset of all 8.8 million recorded deaths in South Africa between 1997 and 2013. Mortality and temperature data were linked at the district municipality level and relationships were estimated with a distributed lag non-linear model with 21 days of lag, and pooled in a multivariate meta-analysis...
November 18, 2017: Environmental Research
https://www.readbyqxmd.com/read/29161636/infant-hpa-axis-as-a-potential-mechanism-linking-maternal-mental-health-and-infant-telomere-length
#9
Benjamin W Nelson, Nicholas B Allen, Heidemarie Laurent
Maternal depression has been suggested to be an independent risk factor for both dysregulated hypothalamic-pituitary-adrenal axis (HPA) functioning and shorter telomere length in offspring. In contrast, research suggests that individual differences in mindfulness may act as a protective factor against one's own telomere degradation. Currently, research has yet to investigate the association between longitudinal changes in maternal mental health (depressive symptoms and mindfulness) and salivary infant telomere length, and whether such changes might be mediated by alterations in infant cortisol response...
November 18, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29161632/ambient-air-pollution-adipokines-and-glucose-homeostasis-the-framingham-heart-study
#10
Wenyuan Li, Kirsten S Dorans, Elissa H Wilker, Mary B Rice, Itai Kloog, Joel D Schwartz, Petros Koutrakis, Brent A Coull, Diane R Gold, James B Meigs, Caroline S Fox, Murray A Mittleman
OBJECTIVE: To examine associations of proximity to major roadways, sustained exposure to fine particulate matter (PM2.5), and acute exposure to ambient air pollutants with adipokines and measures of glucose homeostasis among participants living in the northeastern United States. METHODS: We included 5958 participants from the Framingham Offspring cohort examination cycle 7 (1998-2001) and 8 (2005-2008) and Third Generation cohort examination cycle 1 (2002-2005) and 2 (2008-2011), who did not have type 2 diabetes at the time of examination visit...
November 18, 2017: Environment International
https://www.readbyqxmd.com/read/29161630/active-epilepsy-prevalence-the-treatment-gap-and-treatment-gap-risk-profile-in-eastern-china-a-population-based-study
#11
Xiaoyan Ding, Yang Zheng, Yi Guo, Chunhong Shen, Shan Wang, Feng Chen, Shengqiang Yan, Meiping Ding
We measured the prevalence of active epilepsy and investigated the treatment gap and treatment gap risk profile in eastern China. This was a cross-sectional population-based survey conducted in Zhejiang, China, from October 2013 to March 2014. A total 54,976 people were selected using multi-stage cluster sampling. A two-stage questionnaire-based process was used to identify patients with active epilepsy and to record their demographic, socioeconomic, and epilepsy-related features. Logistic regression analysis was used to analyze risk factors of the treatment gap in eastern China, as adjusted for age and sex...
November 18, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29161624/are-there-associations-with-age-and-sex-in-walking-stability-in-healthy-older-adults
#12
Daan van Kooten, Florentina Hettinga, Kim Duffy, Jo Jackson, Matthew J D Taylor
The variability of the centre of pressure (COP) during walking can provide information in relation to stability when walking. The aim of this study was to investigate if age and sex were associated with COP variability, COP excursions, and COP velocities during walking. One-hundred and fourteen older adults (age 65.1±5.5 yrs.) participated in the study. A Kistler force platform (1000Hz) recorded the ground reaction forces and COPs during walking at a self-selected walking speed. The stance phase was divided, using the vertical GRF, into four sub-phases: loading response (LR), mid-stance (MSt), terminal stance (TSt), and pre-swing (PSw)...
November 13, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29161609/cancers-in-france-in-2015-attributable-to-high-body-mass-index
#13
Melina Arnold, Marina Touillaud, Laure Dossus, Heinz Freisling, Freddie Bray, Irène Margaritis, Valérie Deschamps, Isabelle Soerjomataram
BACKGROUND: Overweight, as defined by high body mass index (BMI), is an established risk factor for various morbidities including cancer. Globally, its prevalence has increased markedly over the past decades. The aim of this study was to estimate the proportion and number of cancers that were attributable to high BMI in France in 2015. METHODS: Population attributable fractions (PAFs) and numbers of cancer cases attributable to high BMI (a population mean BMI above the optimum of 22kg/m(2)) were estimated by age and sex, for cancer sites with convincing or probable evidence of an established causal link...
November 18, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29161577/histological-characteristics-of-the-gonads-of-pig-fetuses-and-their-relationship-with-fetal-anatomical-measurements
#14
Thais Preisser Pontelo, José Rafael Miranda, Matheus Augusto Rodrigues Felix, Barbara Azevedo Pereira, William Eduardo da Silva, Gleide Fernandes Avelar, Flávia Cristina Martins Queiroz Mariano, Gregório Corrêa Guimarães, Márcio Gilberto Zangeronimo
The objective was to evaluate the histomorphometric characteristics of the testis and ovaries of pig fetuses at different gestational ages, as well as their correlation with some fetus measurements. Forty-four fetuses were separated for gender (male and female) and gestational age (50, 80 and 106days of gestation). After slaughter, fetuses had their body length, head and thoracic perimeters measured and their gonads submitted to histomorphometric analyses. The gonadal characteristics at different gestational ages were statistically compared, correlations with the fetal measurements were performed and equations to predict the gonadal characteristics from the fetal measurements were obtained...
November 11, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29161540/delirium-symptoms-are-associated-with-decline-in-cognitive-function-between-ages-53-and-69-years-findings-from-a-british-birth-cohort-study
#15
A Tsui, D Kuh, M Richards, D Davis
INTRODUCTION: Few population studies have investigated whether longitudinal decline after delirium in mid-to-late life might affect specific cognitive domains. METHODS: Participants from a birth cohort completing assessments of search speed, verbal memory, and the Addenbrooke's Cognitive Examination at age 69 were asked about delirium symptoms between ages 60 and 69 years. Linear regression models estimated associations between delirium symptoms and cognitive outcomes...
November 18, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29161531/pulmonary-safety-and-tolerability-of-inhaled-levodopa-cvt-301-administered-to-patients-with-parkinson-s-disease
#16
Peter A LeWitt, Rajesh Pahwa, Alexander Sedkov, Ann Corbin, Richard Batycky, Harald Murck
BACKGROUND: CVT-301, an inhaled levodopa (LD) formulation, is under development for relief of OFF periods in Parkinson's disease (PD). Previously, we reported that CVT-301 improved OFF symptoms relative to placebo. In this study, we evaluate pulmonary function in patients treated with a single dose of CVT-301 or placebo for 3 hours, or received multiple doses/day for 4 weeks. METHODS: As part of two phase 2 studies, pulmonary safety and tolerability of CVT-301 were evaluated in PD patients experiencing motor fluctuations (≥2 hours OFF/day), Hoehn and Yahr stage 1-3, and forced expiratory volume in 1 second/forced vital capacity ratio ≥75% of predicted (in ON state)...
November 21, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/29161522/development-of-a-measure-to-assess-parent-perceptions-of-barriers-to-child-weight-management
#17
Katherine E Darling, Amy F Sato, Manfred van Dulmen, Christopher Flessner, Geoffrey Putt
BACKGROUND: Families face many barriers related to creating or maintaining a healthy lifestyle, which likely contributes to the prevalence of childhood obesity in the United States; however, no measure currently exists to examine these barriers. This study developed a quantitative measure of parents' perceptions of barriers to family healthy lifestyle. METHODS: Parents of children between the ages of 7-17 were recruited using Amazon Mturk (n = 812). Exploratory and confirmatory factor analyses and preliminary convergent validity analyses were conducted...
November 21, 2017: Childhood Obesity
https://www.readbyqxmd.com/read/29161471/peer-to-peer-mentoring-for-african-american-women-with-lupus-a-feasibility-pilot
#18
Edith M Williams, J Madison Hyer, Ramakrishnan Viswanathan, Trevor D Faith, Delia Voronca, Mulugeta Gebregzaibher, Jim C Oates, Leonard Egede
OBJECTIVE: To examine the feasibility and potential benefits of peer mentoring to improve the disease self-management and quality of life of individuals with systemic lupus erythematosus (SLE). METHODS: Peer mentors were trained and paired with up to three mentees to receive self-management education and support by telephone over 12 weeks. This study took place at an academic teaching hospital in Charleston, South Carolina. Seven quads consisting of one peer mentor and three mentees were matched based on factors such as age, area of residence, marital and work status...
November 21, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29161463/the-il-21-mtor-axis-blocks-treg-differentiation-and-function-by-suppression-of-autophagy-in-patients-with-systemic-lupus-erythematosus
#19
Hiroshi Kato, Andras Perl
OBJECTIVES: The mechanistic target of rapamycin (mTOR) has become a therapeutic target in systemic lupus erythematosus (SLE). mTOR regulates normal T-cell lineage specification, including development of regulatory cells (Tregs). Therefore, we investigated whether mTOR is activated within Tregs and causes their depletion and dysfunction in patients with SLE. METHODS: Activities of mTOR complexes 1 (mTORC1) and 2 (mTORC2) were examined by phosphorylation of 4E-BP1, S6K, and Akt, respectively, in SLE patients relative to healthy control females age-matched for each experiment...
November 21, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29161431/volunteering-in-the-community-potential-benefits-for-cognitive-aging
#20
Hayley Guiney, Liana Machado, Bob G Knight
Objectives: This review aims to advance understanding of the potential benefits of volunteering in the community for older adults' cognitive functioning by taking an in-depth look at the relevant evidence to date. Method: This review describes the main pathways through which volunteering could plausibly benefit cognitive functioning and critically examines research that has specifically investigated links between volunteering and cognition. Fifteen articles that assessed in adults aged ≥ 55 years the relationship between volunteering (predictor) and cognitive functioning (outcome) were identified via literature database searches...
November 17, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
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