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https://www.readbyqxmd.com/read/28346954/evaluation-of-probably-benign-adnexal-masses-in-postmenopausal-women
#1
Burcu Kisa Karakaya, Emre Ozgu, Hatice Celik Kansu, Ozlem Evliyaoglu, Esma Sarikaya, Bugra Coskun, Salim Erkaya
Background Preoperatively identification of malignancy potential of a postmenopausal adnexal masses is important. Aim To evaluate the effectiveness of the Risk of Malignancy Index-2 in presumably benign adnexal masses in postmenopausal women. Study Design Retrospective, observational study. Methods 119 women with postmenopausal adnexal masses with a preliminary diagnosis of benign tumors according to the Risk of Malignancy Index-2 were included. Age, duration of menopause, ultrasonographic findings, and serum CA-125 levels were recorded preoperatively...
March 27, 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28346917/endocrine-long-term-follow-up-of-children-with-neurofibromatosis-type-1-and-optic-pathway-glioma%C3%A2
#2
Ilaria Sani, Assunta Albanese
BACKGROUND/AIMS: Children with optic pathway glioma (OPG) face sequelae related to tumour location and treatment modalities. We aimed to assess the prevalence of hypothalamic-pituitary dysfunctions in children with neurofibromatosis type 1 (NF1) and OPG who did not receive radiotherapy or surgical resection. The causative role of tumour location on endocrinopathy development is investigated. METHODS: A retrospective follow-up study of 40 children with NF1 and OPG evaluated between August 1996 and May 2015 was undertaken...
March 27, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28346858/circulating-soluble-il-6-receptor-concentration-and-visceral-adipocyte-size-are-related-to-insulin-resistance-in-taiwanese-adults-with-morbid-obesity
#3
Feng-Chih Kuo, Ya-Hsien Huang, Fu-Huang Lin, Yi-Jen Hung, Chang-Hsun Hsieh, Chieh-Hua Lu, Sheng-Chiang Su, Chia-Luen Huang, Chien-Hsing Lee, Nain-Feng Chu
BACKGROUND: Morbid obesity is related to chronic inflammation and many metabolic complications. Interleukin (IL)-6 plays a pivotal pathophysiological role in obesity, and IL-6 trans-signaling through the soluble IL-6 receptor (sIL-6R) has a major proinflammatory effect. The aim of this study was to investigate the association between sIL-6R, adipocyte size, and insulin resistance in morbidly obese individuals. METHODS: We measured concentrations of sIL-6R, high-sensitivity C-reactive protein, and lipid parameters and estimated homeostasis model assessment of insulin resistance (HOMA-IR) before the patients underwent bariatric surgery...
March 27, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28346817/the-psychosocial-work-environment-is-associated-with-risk-of-stroke-at-working-age
#4
Katarina Jood, Nadine Karlsson, Jennie Medin, Hélène Pessah-Rasmussen, Per Wester, Kerstin Ekberg
Objective The aim of this study was to explore the relation between the risk of first-ever stroke at working age and psychological work environmental factors. Methods A consecutive multicenter matched 1:2 case-control study of acute stroke cases (N=198, age 30-65 years) who had been working full-time at the time of their stroke and 396 sex- and age-matched controls. Stroke cases and controls answered questionnaires on their psychosocial situation during the previous 12 months. The psychosocial work environment was assessed using three different measures: the job-control-demand model, the effort-reward imbalance (ERI) score, and exposures to conflict at work...
March 27, 2017: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/28346816/child-adult-differences-in-using-dual-task-paradigms-to-measure-listening-effort
#5
Erin M Picou, Lauren M Charles, Todd A Ricketts
Purpose: The purpose of the project was to investigate the effects modifying the secondary task in a dual-task paradigm to measure objective listening effort. To be specific, the complexity and depth of processing were increased relative to a simple secondary task. Method: Three dual-task paradigms were developed for school-age children. The primary task was word recognition. The secondary task was a physical response to a visual probe (simple task), a physical response to a complex probe (increased complexity), or word categorization (increased depth of processing)...
March 27, 2017: American Journal of Audiology
https://www.readbyqxmd.com/read/28346806/active-surveillance-in-younger-men-with-prostate-cancer
#6
Michael S Leapman, Janet E Cowan, Hao G Nguyen, Katsuto K Shinohara, Nannette Perez, Matthew R Cooperberg, William J Catalona, Peter R Carroll
Purpose The suitability of younger patients with prostate cancer (PCa) for initial active surveillance (AS) has been questioned on the basis of eventual treatment necessity and concerns of safety; however, the role of age on surveillance outcomes has not been well defined. Patients and Methods We identified men managed with AS at our institution with a minimum follow-up of 6 months. The primary study objective was to examine the association of age with risk of biopsy-based Gleason score upgrade during AS. We also examined the association of age with related end points, including overall biopsy-determined progression, definitive treatment, and pathologic and biochemical outcomes after delayed radical prostatectomy (RP), using descriptive statistics, the Kaplan-Meier method, and multivariable Cox proportional hazards regression...
March 27, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28346765/the-medial-temporal-memory-system-in-down-syndrome-translating-animal-models-of-hippocampal-compromise
#7
Caron A C Clark, Fabian Fernandez, Stella Sakhon, Goffredina Spanò, Jamie O Edgin
Recent studies have highlighted the dentate gyrus as a region of increased vulnerability in mouse models of Down syndrome (DS). It is unclear to what extent these findings are reflected in the memory profile of people with the condition. We developed a series of novel tasks to probe distinct medial temporal functions in children and young adults with DS, including object, spatial, and serial order memory. Relative to mental age-matched controls (n = 45), individuals with DS (n = 28) were unimpaired on subtests involving short-term object or configural recall that was divorced from spatial or temporal contexts...
March 27, 2017: Hippocampus
https://www.readbyqxmd.com/read/28346746/simultaneous-determination-of-4-hydroxyphenyl-lactic-acid-4-hydroxyphenyl-acetic-acid-and-3-4-hydroxyphenyl-propionic-acid-in-human-urine-by-ultra-high-performance-liquid-chromatography-with-fluorescence-detection
#8
Yongli Yang, Fan Liu, Yiqun Wan
A simple and reliable method was established for simultaneous determination of 4-hydroxyphenyl acetic acid, 4-hydroxyphenyl lactic acid, and 3-4-hydroxyphenyl propionic acid in human urine by high-performance liquid chromatography with fluorescence detection. Solid-phase extraction was used to eliminate the interferences in urine. The separation of three analytes was achieved using a C18 column and a mobile phase formed by a 95:5 v/v mixture of 50 mmol/L ammonium acetate buffer at pH 6.8 that contained 5 mmol/L tetrabutyl ammonium bromide and acetonitrile...
March 27, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28346685/experience-of-shame-mediates-the-relationship-between-pathological-narcissism-and-suicidal-ideation-in-psychiatric-outpatients
#9
Nenad Jaksic, Darko Marcinko, Milena Skocic Hanzek, Blaz Rebernjak, John S Ogrodniczuk
OBJECTIVE: Pathological narcissism, described by 2 dysfunctional phenotypic forms-grandiosity and vulnerability-has often been connected to suicidal tendencies in theoretical and clinical literatures. Furthermore, shame proneness has been implicated as a key mechanism that links these 2 constructs. However, empirical evidence for the presumed relationship between pathological narcissism and suicidal tendencies is sparse, and no prior research has investigated the role of shame proneness in this relationship...
March 27, 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/28346682/age-related-variation-in-the-cellular-composition-of-equine-bronchoalveolar-lavage-fluid
#10
Shannon J Hostetter, Sandra K Clark, Jessica M Gilbertie, Sarah A Wiechert, Doug E Jones, Brett A Sponseller
BACKGROUND: Previous reports reveal variation in the cellular composition of equine bronchoalveolar lavage fluid (BALF). OBJECTIVES: The purpose of this study was to compare the profiles of BALF from horses to assess age-related differences. Serial BALF samples were collected from the same individuals over a one-year period to identify changes in individual animals as they aged. METHODS: Collection of BALF was performed on horses aged one week and one, 2, 6, and 12 months...
March 27, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28346661/a-major-shift-in-diversification-rate-helps-explain-macroevolutionary-patterns-in-primate-species-diversity
#11
Jessica H Arbour, Sharlene E Santana
Primates represent one of the most species rich, wide ranging and ecologically diverse clades of mammals. What major macroevolutionary factors have driven their diversification and contributed to the modern distribution of primate species remains widely debated. We employed phylogenetic comparative methods to examine the role of clade age and evolutionary rate heterogeneity in the modern distribution of species diversity of Primates. Primate diversification has accelerated since its origin, with decreased extinction leading to a shift to even higher evolutionary rates in the most species rich family (Cercopithecidae)...
March 27, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/28346656/7-year-follow-up-after-stereotactic-ablative-radiotherapy-for-patients-with-stage-i-non-small-cell-lung-cancer-results-of-a-phase-2-clinical-trial
#12
Bing Sun, Eric D Brooks, Ritsuko U Komaki, Zhongxing Liao, Melenda D Jeter, Mary F McAleer, Pamela K Allen, Peter A Balter, James D Welsh, Michael S O'Reilly, Daniel Gomez, Stephen M Hahn, Jack A Roth, Reza J Mehran, John V Heymach, Joe Y Chang
BACKGROUND: The authors evaluated the efficacy, patterns of failure, and toxicity of stereotactic ablative radiotherapy (SABR) for patients with medically inoperable, clinical stage I non-small cell lung cancer (NSCLC) in a prospective clinical trial with 7 years of follow-up. Clinical staging was performed according to the seventh edition of the American Joint Committee on Cancer TNM staging system. METHODS: Eligible patients with histologically confirmed NSCLC of clinical stage I as determined using positron emission tomography staging were treated with SABR (50 grays in 4 fractions)...
March 27, 2017: Cancer
https://www.readbyqxmd.com/read/28346588/association-between-childhood-onset-epilepsy-and-amyloid-burden-5-decades-later
#13
Juho Joutsa, Juha O Rinne, Bruce Hermann, Mira Karrasch, Anu Anttinen, Shlomo Shinnar, Matti Sillanpää
Importance: The effect of childhood epilepsy on later-life cognitive and brain health is an unclear and little-explored issue. Objective: To determine whether adults with a history of childhood-onset epilepsy exhibit increased brain amyloid accumulation, possibly predisposing to accelerated cognitive impairment or even frank cognitive disorders in later life. Design, Setting, and Participants: Forty-one adults from a population-based cohort of individuals with childhood-onset epilepsy in southwestern Finland, together with 46 matched population-based controls, underwent amyloid ligand carbon 11-labeled Pittsburgh Compound B (PiB) positron emission tomography after long-term prospective follow-up...
March 27, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28346575/perceptions-of-healthcare-professionals-on-the-usage-of-percutaneous-endoscopic-gastrostomy-in-a-teaching-hospital-from-a-middle-income-south-east-asian-country
#14
M H Jaafar, S Mahadeva, P Subramanian, M P Tan
OBJECTIVE: To explore the perceptions of healthcare professionals' (HCPs) in a South East Asian nation towards percutaneous endoscopic gastrostomy (PEG) feeding. DESIGN: Semi-structured, qualitative interviews. SETTINGS: A teaching hospital in Kuala Lumpur, Malaysia. PARTICIPANTS: A total of 17 healthcare professionals aged 23-43 years, 82% women. RESULTS: Thematic analysis revealed five themes that represent HCPs' perceptions in relation to the usage of PEG feeding: 1) knowledge of HCPs, 2) communication, 3) understanding among patients, and 4) financial and affordability...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28346571/is-the-ergogenicity-of-caffeine-affected-by-increasing-age-the-direct-effect-of-a-physiological-concentration-of-caffeine-on-the-power-output-of-maximally-stimulated-edl-and-diaphragm-muscle-isolated-from-the-mouse
#15
J Tallis, R S James, V M Cox, M J Duncan
INTRODUCTION: Caffeine is a well-established performance enhancing nutritional supplement in a young healthy population, however far less is known about how its ergogenicity is affected by increasing age. A recent review has highlighted the value of studies examining the direct effect of caffeine on isolated skeletal muscle contractility, but the present work is the first to assess the direct effect of 70µM caffeine (physiological maximum) on the maximal power output of isolated mammalian muscle from an age range representing developmental to early ageing...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28346570/tolerance-and-long-term-efficacy-of-polyethylene-glycol-4000-forlax%C3%A2-compared-to-lactulose-in-elderly-patients-with-chronic-constipation
#16
P Chassagne, P Ducrotte, P Garnier, H Mathiex-Fortunet
OBJECTIVES: To assess the tolerance and potential nutritional consequences of long-term repeated doses of PEG 4000 (10 to 30 g/day) in elderly patients with chronic constipation as compared to lactulose (10-30 g/day). DESIGN: Single blind, randomised, multicentre, parallel group comparative study. SETTING: Community-dwelling patients and nursing homes residents aged 70 years and older with a history of chronic constipation. Treatment intervention: PEG 4000 (10-30 g/day) or lactulose (10-30 g/day) for six months...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28346567/effect-of-a-low-glycemic-index-mediterranean-diet-on-non-alcoholic-fatty-liver-disease-a-randomized-controlled-clinici-trial
#17
G Misciagna, M Del Pilar Díaz, D V Caramia, C Bonfiglio, I Franco, M R Noviello, M Chiloiro, D I Abbrescia, A Mirizzi, M Tanzi, M G Caruso, M Correale, R Reddavide, R Inguaggiato, A M Cisternino, A R Osella
INTRODUCTION: Non-Alcoholic Fatty Liver Disease (NAFLD) is currently the most common form of liver disease worldwide affecting all ages and ethnic groups and it has become a consistent threat even in young people. Our aim was to estimate the effect of a Low Glycemic Index Mediterranean Diet (LGIMD) on the NAFLD score as measured by a Liver Ultrasonography (LUS). DESIGN: NUTRIzione in EPAtologia (NUTRIEPA) is a population-based Double-Blind RCT. Data were collected in 2011 and analyzed in 2013-14...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28346565/anticholinergic-burden-and-functional-status-in-older-people-with-cognitive-impairment-results-from-the-regal-project
#18
V Boccardi, M Baroni, L Paolacci, S Ercolani, A Longo, M Giordano, C Ruggiero, P Mecocci
OBJECTIVE: The use of drugs with intrinsic anticholinergic properties is widespread among old age persons. A growing body of evidences suggest that a high anticholinergic burden is associated with physical and cognitive impairment. However, the association between anticholinergic drug use and functional status is still poorly investigated, particularly among subjects with initial cognitive impairment. DESIGN: Cross-sectional study examining the association between drug-related anticholinergic burden and functional status in cognitively healthy (CH) (n=691), mild cognitive impairment (MCI) (n=541) or mild Alzheimer's diseases (AD) (n=1127) subjects...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28346561/reduced-intestinal-motility-mucosal-barrier-function-and-inflammation-in-aged-monkeys
#19
E L Mitchell, A T Davis, K Brass, M Dendinger, R Barner, R Gharaibeh, A A Fodor, K Kavanagh
OBJECTIVE: We aimed to examine the general health and intestinal physiology of young and old non-human primates with comparable life histories and dietary environments. DESIGN: Vervet monkeys (Chlorcebus aethiops sabaeus) in stable and comparable social and nutritional environments were selected for evaluation. Health phenotype, circulating cytokines and biomarkers of microbial translocation (MT) were measured (n=26-44). Subsets of monkeys additionally had their intestinal motility, intestinal permeability, and fecal microbiomes characterized...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28346541/quality-of-life-and-objective-outcome-assessment-in-women-with-tape-division-after-surgery-for-stress-urinary-incontinence
#20
Daniela Ulrich, Vesna Bjelic-Radisic, Anna Höllein, Gerda Trutnovsky, Karl Tamussino, Thomas Aigmüller
BACKGROUND: Midurethral tapes may cause long-term complications such as voiding dysfunction, groin pain, de novo urgency or mesh erosion, which necessitate a reoperation. There is a paucity of data regarding health related quality of life in patients undergoing tape removal. The aim of the study was to evaluate quality of life (QoL) and objective outcome after midurethral tape division or excision. METHODS: All patients who underwent a midurethral tape division for voiding difficulties, pain or therapy resistant de novo overactive bladder between 1999 and 2014 were invited for follow-up...
2017: PloS One
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