Yu Feng, Keziah S Diego, Zhe Dong, Zoé Christenson Wick, Lucia Page-Harley, Veronica Page-Harley, Julia Schnipper, Sophia I Lamsifer, Zachary T Pennington, Lauren M Vetere, Paul A Philipsberg, Ivan Soler, Albert Jurkowski, Christin J Rosado, Nadia N Khan, Denise J Cai, Tristan Shuman
Temporal lobe epilepsy (TLE) causes pervasive and progressive memory impairments, yet the specific circuit changes that drive these deficits remain unclear. To investigate how hippocampal-entorhinal dysfunction contributes to progressive memory deficits in epilepsy, we performed simultaneous in vivo electrophysiology in hippocampus (HPC) and medial entorhinal cortex (MEC) of control and epileptic mice 3 or 8 weeks after pilocarpine-induced status epilepticus (Pilo-SE). We found that HPC synchronization deficits (including reduced theta power, coherence, and altered interneuron spike timing) emerged within 3 weeks of Pilo-SE, aligning with early-onset, relatively subtle memory deficits...
March 14, 2024: bioRxiv