Lianggong Ding, Florian Huwyler, Fen Long, Wu Yang, Jonas Binz, Kendra Wernlé, Matthias Pfister, Manuel Klug, Miroslav Balaz, Barbara Ukropcova, Jozef Ukropec, Chunyan Wu, Tongtong Wang, Min Gao, Pierre-Alain Clavien, Philipp Dutkowski, Mark W Tibbitt, Christian Wolfrum
Metabolic crosstalk of the major nutrients glucose, amino acids and fatty acids (FAs) ensures systemic metabolic homeostasis. The coordination between the supply of glucose and FAs to meet various physiological demands is especially important as improper nutrient levels lead to metabolic disorders, such as diabetes and metabolic dysfunction-associated steatohepatitis (MASH). In response to the oscillations in blood glucose levels, lipolysis is thought to be mainly regulated hormonally to control FA liberation from lipid droplets by insulin, catecholamine and glucagon...
April 1, 2024: Nature Cell Biology