Giovanni Occhipinti, Claudio Laudani, Marco Spagnolo, Simone Finocchiaro, Placido Maria Mazzone, Denise Cristiana Faro, Maria Sara Mauro, Carla Rochira, Federica Agnello, Daniele Giacoppo, Nicola Ammirabile, Davide Landolina, Antonino Imbesi, Giuseppe Sangiorgio, Antonio Greco, Davide Capodanno
The evolution of anticoagulation therapy, from vitamin K antagonists to the advent of direct oral anticoagulants (DOACs) almost two decades ago, marks significant progress. Despite improved safety demonstrated in pivotal trials and post-marketing observations, persistent concerns exist, particularly regarding bleeding risk and the absence of therapeutic indications in specific subgroups or clinical contexts. Factor XI (FXI) has recently emerged as a pivotal contributor to intraluminal thrombus formation and growth, playing a limited role in sealing vessel wall injuries...
January 9, 2024: European Heart Journal. Cardiovascular Pharmacotherapy