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Seprafilm

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https://www.readbyqxmd.com/read/28557204/anti-adhesive-effects-of-a-newly-developed-two-layered-gelatin-sheet-in-dogs
#1
Hiroko Torii, Toshitaka Takagi, Mamoru Urabe, Hiroyuki Tsujimoto, Yuki Ozamoto, Hiroe Miyamoto, Yoshihito Ikada, Akeo Hagiwara
AIM: Adhesion after pelvic surgery causes infertility, ectopic pregnancy, and ileus or abdominal pain. The materials currently available for clinical use are insufficient. The purpose of this study was to develop an anti-adhesive material that overcomes the limitations of conventional anti-adhesive agents. METHODS: The adhesion prevention effects of three methods - a two-layered sheet composed of gelatin film and gelatin sponge, Seprafilm and INTERCEED - were evaluated in 37 dogs...
May 29, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28400696/seprafilm%C3%A2-application-method-in-laparoscopic-surgery
#2
Mun-Kun Hong, Dah-Ching Ding
BACKGROUND AND OBJECTIVES: Postoperative adhesions occur less often in laparoscopies than in laparotomies, but the incidence can be reduced further. Seprafilm, a sodium hyaluronate/carboxymethylcellulose absorbable barrier, was developed to prevent adhesions after abdominal surgery, and is approved for postoperative adhesion prevention. However, Seprafilm is seldom used in laparoscopic surgery because of its tendency to break apart when it is inserted into the abdominal cavity through a trocar, resulting in a high placement failure rate...
January 2017: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/28293518/the-use-of-a-hyaluronic-acid-carboxymethylcellulose-membrane-as-an-adhesion-barrier-during-nipple-delay-before-nipple-preserving-mastectomy
#3
Andreas M Lamelas, Eric M Jablonka, Marco A Harmaty, Philip J Torina
The desire for nipple-preserving mastectomies has increased over the past decade as studies have proven that the procedure has comparable oncologic risk as a traditional mastectomy in both therapeutic and prophylactic cases. Partial or complete nipple necrosis is a well-known complication of this procedure with rates in the literature ranging between 1% and 9%. In high-risk patients, surgeons are performing a delay procedure before the mastectomy to help improve nipple vascularity and decrease necrosis rates...
December 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28266968/long-term-follow-up-of-adhesion-prevention-with-use-of-hyaluronic-acid-carboxymethylcellulose-membrane-seprafilm
#4
Tzu-An Chen, Chien-Yuh Yeh
No abstract text is available yet for this article.
April 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28263453/tissue-response-to-five-commercially-available-peritoneal-adhesion-barriers-a-systematic-histological-evaluation
#5
Volker H Schmitt, Andreas Mamilos, Christine Schmitt, Constanze N E Neitzer-Planck, Taufiek K Rajab, David Hollemann, Willi Wagner, Bernhard Krämer, Helmut Hierlemann, C James Kirkpatrick, Christoph Brochhausen
Separating wounded serosa by physical barriers is the only clinically approved adjunct for postoperative adhesion prevention. Since the optimal adhesion barrier has not been found, it is essential to improve our pathogenic understanding of adhesion formation and to compare the effects of different barrier materials on tissue and cells. Wistar rats underwent standardized peritoneal damage and were treated either with Seprafilm, Adept, Intercoat, Spraygel, SupraSeal or remained untreated as a control. 14 days postoperatively, the lesions were explanted and histomorphologically analyzed using the European ISO score to evaluate material implants...
March 6, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28207824/evaluation-of-surgical-anti-adhesion-products-to-reduce-postsurgical-intra-abdominal-adhesion-formation-in-a-rat-model
#6
Long-Xiang Lin, Fang Yuan, Hui-Hui Zhang, Ni-Na Liao, Jing-Wan Luo, Yu-Long Sun
BACKGROUND: Adhesions frequently occur after abdominal surgery. Many anti-adhesion products have been used in clinic. However, the evidences are short for surgeons to reasonably choose the suitable anti-adhesion produces in clinical practice. This study provided such evidence by comparing the efficiency of five products to prevent abdominal adhesion formation in a rat model. METHODS: Fifty-six Sprague-Dawley rats were randomly divided into seven groups: sham-operation group, adhesion group, and five product groups (n = 8)...
2017: PloS One
https://www.readbyqxmd.com/read/28128794/patching-retinal-breaks-with-seprafilm-for-treating-retinal-detachments-in-humans-9-years-of-follow-up
#7
M Haruta, M Arai, J Sueda, T Hirose, R Yamakawa
PurposeTo describe the long-term surgical outcomes of four patients treated for retinal detachment using Seprafilm as a novel technique.MethodsRetinal breaks in four eyes were covered with Seprafilm using a transvitreal approach after cataract surgery, pars plana vitrectomy, fluid-air exchange, and laser photocoagulation. Neither long-standing gas nor silicone oil was used. The patients were not instructed to maintain a specific head positioning postoperatively.ResultsSuccessful retinal reattachment was achieved with a single surgery in all four eyes, and none developed proliferative vitreoretinopathy...
May 2017: Eye
https://www.readbyqxmd.com/read/27525202/evaluation-of-the-xenobiotic-reaction-against-hyaluronate-based-bioresorbable-membrane-in-the-abdominal-cavity
#8
Masaaki Nagata, Namiko Hoshi, Hayato Yoshinaka, Hideyuki Shiomi, Mamoru Takenaka, Atsuhiro Masuda, Yumi Maruyama, Ray Uchida, Takeshi Azuma, Hiromu Kutsumi
Postoperative abdominal adhesions are one of the most common post-laparotomy complications observed. Several types of adhesion preventative agents are available and their effectiveness and adverse impact have been clinically evaluated in previous studies. However, few basic studies have tested whether those agents do not trigger any unwanted xenobiotic reaction, which makes some surgeons hesitant to use them. To clarify this point, we investigated whether the adhesion preventative agent Seprafilm(®) (KAKEN PHARMACEUTICAL CO...
2016: Progress in biomaterials
https://www.readbyqxmd.com/read/27429589/evaluation-of-the-effectiveness-of-peritoneal-adhesion-prevention-devices-in-a-rat-model
#9
D Poehnert, L Grethe, L Maegel, D Jonigk, T Lippmann, A Kaltenborn, H Schrem, J Klempnauer, M Winny
BACKGROUND: Abdominal operations are followed by adhesions, a prevalent cause of abdominal pain, and the most frequent cause for bowel obstruction and secondary female infertility. This rat study addresses adhesion prevention capability of Adept(®), Interceed(®), Seprafilm(®), and a novel device, 4DryField(®) PH which is provided as powder and generates its effect as gel. METHODS: Sixty-eight male Lewis rats had cecal abrasion and creation of an equally sized abdominal wall defect, and were grouped randomly: A control group without treatment (n=10); two groups treated with 4DryField(®) PH using premixed gel (n=15) or in-situ gel technique (n=16); one group each was treated with Seprafilm(®) (n=8), Interceed(®) (n=9), or Adept(®) (n=10)...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27426659/sepramesh-and-postoperative-peritoneal-adhesions-in-a-rat-model
#10
Willy Arung, Pierre Drion, Olivier Detry
PURPOSE: The present study aimed to investigate the safety and the anti-postoperative peritoneal adhesion (PPA) characteristics of Sepramesh(®) (Davol), a composite mesh made of polypropylene covered with Seprafilm, when intraperitoneally placed in a rat model. METHODS: Twenty male rats were randomized into a control group and a Sepramesh group. They underwent a primary surgical procedure aiming to induce a peritoneal injury in order to induce PPAs. In the Sepramesh group, the burnt peritoneum was covered with a 2-cm diameter disc of Sepramesh prosthesis...
December 2016: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/27386295/comparison-of-the-effects-of-mitomycin-c-and-sodium-hyaluronate-carboxymethylcellulose-nh-cmc-seprafilm-on-abdominal-adhesions
#11
Ismail Hakkı Ozerhan, Murat Urkan, Ulvi Mehmet Meral, Aytekin Unlu, Nail Ersöz, Funda Demirag, Gokhan Yagci
INTRODUCTION: Intra-abdominal adhesions (IA) may occur after abdominal surgery and also may lead to complications such as infertility, intestinal obstruction and chronic pain. The aim of this study was to compare the effects of Mitomycin-C (MM-C) and sodium hyaluronate/carboxymethylcellulose [NH/CMC] on abdominal adhesions in a cecal abrasion model and to investigate the toxicity of MM-C on complete blood count (CBC) and bone marrow analyses. METHODS: The study comprised forty rats in four groups (Control, Sham, Cecal abrasion + MM-C, and Cecal abrasion + NH/CMC)...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27355746/the-potential-efficacy-of-survanta-r-and-seprafilm-r-on-preventing-intra-abdominal-adhesions-in-rats
#12
Ersoy Arslan, Oktay Irkorucu, Alper Sozutek, Suleyman Cetinkunar, Enver Reyhan, Abit Yaman, Figen Doran
PURPOSE: To investigate the potential efficacy of beractant (Survanta(r)) and Seprafilm(r) on the prevention of postoperative adhesions. METHODS: Forty Wistar-albino female rats were used. The rats were randomly allocated into four groups of 10 rats each as control group (CG), beractant group (BG), Seprafilm(r) group (SG), and combined group (COG). All rats underwent cecal abrasion via midline laparotomy. Before abdominal closure, isotonic saline, beractant, Seprafilm, and combined agents were intraperitoneally administered...
June 2016: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/27167879/regeneration-of-peritoneal-mesothelial-cells-after-placement-of-hyaluronate-carboxymethyl-cellulose-seprafilm-%C3%A2
#13
Hideki Osawa, Junichi Nishimura, Masayuki Hiraki, Hidekazu Takahashi, Naotsugu Haraguchi, Taishi Hata, Masakazu Ikenaga, Kohei Murata, Hirofumi Yamamoto, Tsunekazu Mizushima, Yuichiro Doki, Masaki Mori
PURPOSE: To examine the regeneration of mesothelium under a bioresorbable membrane. METHODS: A 1 cm(2) piece of peritoneum was resected from both sides of the abdominal wall of retired female mice. A piece of hyaluronate and carboxymethyl-cellulose (Seprafilm(®)) was placed over the wound on one side and the other side was left uncovered. We evaluated the degree of adhesion and regeneration of mesothelial cells macroscopically and histologically using immunohistochemistry at different times...
January 2017: Surgery Today
https://www.readbyqxmd.com/read/27011601/simple-and-easy-technique-for-the-placement-of-seprafilm-during-laparoscopic-surgery
#14
Yasuo Sumi, Kimihiro Yamashita, Kiyonori Kanemitsu, Masashi Yamamoto, Shingo Kanaji, Tatsuya Imanishi, Tetsu Nakamura, Satoshi Suzuki, Kenichi Tanaka, Yoshihiro Kakeji
Laparoscopic surgery is a minimally invasive surgery, and the incidence of postoperative small bowel obstruction (SBO) is not high. However, SBO is a disease that detracts from the benefits of laparoscopic surgery due to the need for additional therapies or prolongation of hospital stay. Seprafilm is effective in reducing adhesions and preventing the occurrence of SBO. However, it is very difficult to place the Seprafilm during laparoscopic surgery compared to open surgery. Herein, we report a simple and easy method...
December 2015: Indian Journal of Surgery
https://www.readbyqxmd.com/read/27010523/preventive-effect-of-ethyl-pyruvate-on-postoperative-adhesion-formation-following-abdominal-surgery
#15
Tarik Artis, A Seda Artis, Ergin Arslan, Fatih Mutlu, Abdurrahman Akay, Kemal Deniz
OBJECTIVE: Postoperative adhesions are among the major causes of morbidity and mortality following abdominal surgery. As an antioxidant and antiinflamatory agent, the potential effect of ethyl pyruvate on adhesion prevention has not been clearly studied. We aimed to investigate the possible anti-adhesive effect of ethyl pyruvate compared with an effective barrier membrane, Seprafilm, in a rat cecal abrasion model. MATERIALS AND METHODS: Male Wistar albino rats separated into three adhesion model groups (n = 8, each) with applications of different agents during surgery: control (intraperitoneal normal saline), Seprafilm group (intraperitoneal Seprafilm), and Ethyl pyruvate group (40 mg/kg intraperitoneal ethyl pyruvate)...
October 2016: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/26969960/role-of-anti-adhesive-barriers-following-rotator-cuff-repair-surgery-an-experimental-study
#16
Mahmut Kalem, Ercan Şahin, Murat Songür, Sinan Zehir, Mehmet Armangil, Mehmet A Demirtaş
OBJECTIVE: This experimental study investigates the effectiveness of expanded polytetrafluoroethylene (Dualmesh®, Gore Medical, Flagstaff, AZ, USA), sodium hyaluronate-carboxymethyl cellulose (Seprafilm®, Genzyme, Cambridge, MA, USA), and polysiloxane (silicone) as anti-adhesive barriers for inhibition of fibrosis in the subacromial area following rotator cuff repair. METHODS: Rabbit rotator cuff tenotomy and repair was conducted on 24 rabbits in 4 groups: control (Group A), Dualmesh® (Group B), Seprafilm® (Group C), and silicone (Group D)...
2016: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/26936491/polylactic-acid-nanosheets-in-prevention-of-postoperative-intestinal-adhesion-and-their-effects-on-bacterial-propagation-in-an-experimental-model
#17
A Hinoki, A Saito, M Kinoshita, J Yamamoto, D Saitoh, S Takeoka
BACKGROUND: Ultrathin films (nanosheets) adhere tightly to organ surfaces but prevent adhesion to other organs. The antiadhesive effect of nanosheets and their effect on bacterial propagation were investigated in a murine intestinal adhesion model. METHODS: Polylactic acid nanosheets (approximately 80 nm thick) were produced. Serosal defects were created by peeling off the intestinal serosa; these were left open or covered with nanosheets or Seprafilm® and the formation of intestinal adhesions was analysed...
May 2016: British Journal of Surgery
https://www.readbyqxmd.com/read/26379978/a-bioabsorbable-membrane-seprafilm%C3%A2-may-prevent-postoperative-mediastinal-adhesions-following-mediastinoscopy-an-experimental-study-in-rats
#18
Songül Büyükkale, Necati Çıtak, Özgür İşgörücü, Adnan Sayar
INTRODUCTION: The aim of this experimental study was to investigate the anti-adhesion property of a bioabsorbable membrane following mediastinoscopy in a rat model. METHODS: The study was conducted in 20 male Sprague-Dawley rats. Mediastinoscopy was performed all of them. Rats were divided into two groups; control group (n=10); mediastinoscopy alone, study group (n=10); mediastinoscopy and sodiumhyaluronate-carboxymethlycellulose film (Seprafilm®; Genzyme Corporation, Cambridge, Mass...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/26288251/design-of-high-performance-anti-adhesion-agent-using-injectable-gel-with-an-anti-oxidative-stress-function
#19
Hiroyuki Nakagawa, Yoko Matsumoto, Yu Matsumoto, Yoshihiro Miwa, Yukio Nagasaki
Postsurgical tissue adhesion formation caused by inflammation and oxidative stress is one of the serious issues because it induces severe clinical disorders. In this study, we designed redox injectable gel (RIG) which covalently possesses nitroxide radicals as a reactive oxygen species (ROS) scavenger for high performance anti-adhesion agent. The redox flower micelles exhibiting gelation under physiological conditions were prepared by a polyion complex (PIC) between polyamine-PEG-polyamine triblock copolymer possessing nitroxide radicals as a side chain of polyamine segments and poly(acrylic acid)...
November 2015: Biomaterials
https://www.readbyqxmd.com/read/26115533/prevention-of-peritendinous-adhesions-with-electrospun-polyethylene-glycol-polycaprolactone-nanofibrous-membranes
#20
Chih-Hao Chen, Shih-Hsien Chen, K T Shalumon, Jyh-Ping Chen
Postoperative adhesion formation is the major complication that could occur after acute tendon surgery. The application of an anti-adhesive membrane at the post-surgical site is deemed as a potential way to solve this problem by preventing adhesive fibrotic tissue development. In this study, we fabricated electrospun composite poly(ethylene glycol) (PEG)/poly(caprolactone) (PCL) nanofibrous membrane (NFM) to prevent peritendinous adhesions, which could act as a barrier between the tendon and surrounding tissues, without interrupting mass transfer and normal tendon gliding...
September 1, 2015: Colloids and Surfaces. B, Biointerfaces
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