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Masaaki Nagata, Namiko Hoshi, Hayato Yoshinaka, Hideyuki Shiomi, Mamoru Takenaka, Atsuhiro Masuda, Yumi Maruyama, Ray Uchida, Takeshi Azuma, Hiromu Kutsumi
Postoperative abdominal adhesions are one of the most common post-laparotomy complications observed. Several types of adhesion preventative agents are available and their effectiveness and adverse impact have been clinically evaluated in previous studies. However, few basic studies have tested whether those agents do not trigger any unwanted xenobiotic reaction, which makes some surgeons hesitant to use them. To clarify this point, we investigated whether the adhesion preventative agent Seprafilm(®) (KAKEN PHARMACEUTICAL CO...
2016: Progress in biomaterials
D Poehnert, L Grethe, L Maegel, D Jonigk, T Lippmann, A Kaltenborn, H Schrem, J Klempnauer, M Winny
BACKGROUND: Abdominal operations are followed by adhesions, a prevalent cause of abdominal pain, and the most frequent cause for bowel obstruction and secondary female infertility. This rat study addresses adhesion prevention capability of Adept(®), Interceed(®), Seprafilm(®), and a novel device, 4DryField(®) PH which is provided as powder and generates its effect as gel. METHODS: Sixty-eight male Lewis rats had cecal abrasion and creation of an equally sized abdominal wall defect, and were grouped randomly: A control group without treatment (n=10); two groups treated with 4DryField(®) PH using premixed gel (n=15) or in-situ gel technique (n=16); one group each was treated with Seprafilm(®) (n=8), Interceed(®) (n=9), or Adept(®) (n=10)...
2016: International Journal of Medical Sciences
Willy Arung, Pierre Drion, Olivier Detry
PURPOSE: The present study aimed to investigate the safety and the anti-postoperative peritoneal adhesion (PPA) characteristics of Sepramesh(®) (Davol), a composite mesh made of polypropylene covered with Seprafilm, when intraperitoneally placed in a rat model. METHODS: Twenty male rats were randomized into a control group and a Sepramesh group. They underwent a primary surgical procedure aiming to induce a peritoneal injury in order to induce PPAs. In the Sepramesh group, the burnt peritoneum was covered with a 2-cm diameter disc of Sepramesh prosthesis...
June 2, 2016: Acta Chirurgica Belgica
Ismail Hakkı Ozerhan, Murat Urkan, Ulvi Mehmet Meral, Aytekin Unlu, Nail Ersöz, Funda Demirag, Gokhan Yagci
INTRODUCTION: Intra-abdominal adhesions (IA) may occur after abdominal surgery and also may lead to complications such as infertility, intestinal obstruction and chronic pain. The aim of this study was to compare the effects of Mitomycin-C (MM-C) and sodium hyaluronate/carboxymethylcellulose [NH/CMC] on abdominal adhesions in a cecal abrasion model and to investigate the toxicity of MM-C on complete blood count (CBC) and bone marrow analyses. METHODS: The study comprised forty rats in four groups (Control, Sham, Cecal abrasion + MM-C, and Cecal abrasion + NH/CMC)...
2016: SpringerPlus
Ersoy Arslan, Oktay Irkorucu, Alper Sozutek, Suleyman Cetinkunar, Enver Reyhan, Abit Yaman, Figen Doran
PURPOSE: To investigate the potential efficacy of beractant (Survanta(r)) and Seprafilm(r) on the prevention of postoperative adhesions. METHODS: Forty Wistar-albino female rats were used. The rats were randomly allocated into four groups of 10 rats each as control group (CG), beractant group (BG), Seprafilm(r) group (SG), and combined group (COG). All rats underwent cecal abrasion via midline laparotomy. Before abdominal closure, isotonic saline, beractant, Seprafilm, and combined agents were intraperitoneally administered...
June 2016: Acta Cirúrgica Brasileira
Hideki Osawa, Junichi Nishimura, Masayuki Hiraki, Hidekazu Takahashi, Naotsugu Haraguchi, Taishi Hata, Masakazu Ikenaga, Kohei Murata, Hirofumi Yamamoto, Tsunekazu Mizushima, Yuichiro Doki, Masaki Mori
PURPOSE: To examine the regeneration of mesothelium under a bioresorbable membrane. METHODS: A 1 cm(2) piece of peritoneum was resected from both sides of the abdominal wall of retired female mice. A piece of hyaluronate and carboxymethyl-cellulose (Seprafilm(®)) was placed over the wound on one side and the other side was left uncovered. We evaluated the degree of adhesion and regeneration of mesothelial cells macroscopically and histologically using immunohistochemistry at different times...
May 11, 2016: Surgery Today
Yasuo Sumi, Kimihiro Yamashita, Kiyonori Kanemitsu, Masashi Yamamoto, Shingo Kanaji, Tatsuya Imanishi, Tetsu Nakamura, Satoshi Suzuki, Kenichi Tanaka, Yoshihiro Kakeji
Laparoscopic surgery is a minimally invasive surgery, and the incidence of postoperative small bowel obstruction (SBO) is not high. However, SBO is a disease that detracts from the benefits of laparoscopic surgery due to the need for additional therapies or prolongation of hospital stay. Seprafilm is effective in reducing adhesions and preventing the occurrence of SBO. However, it is very difficult to place the Seprafilm during laparoscopic surgery compared to open surgery. Herein, we report a simple and easy method...
December 2015: Indian Journal of Surgery
Tarik Artis, A Seda Artis, Ergin Arslan, Fatih Mutlu, Abdurrahman Akay, Kemal Deniz
OBJECTIVE: Postoperative adhesions are among the major causes of morbidity and mortality following abdominal surgery. As an antioxidant and antiinflamatory agent, the potential effect of ethyl pyruvate on adhesion prevention has not been clearly studied. We aimed to investigate the possible anti-adhesive effect of ethyl pyruvate compared with an effective barrier membrane, Seprafilm, in a rat cecal abrasion model. MATERIALS AND METHODS: Male Wistar albino rats separated into three adhesion model groups (n = 8, each) with applications of different agents during surgery: control (intraperitoneal normal saline), Seprafilm group (intraperitoneal Seprafilm), and Ethyl pyruvate group (40 mg/kg intraperitoneal ethyl pyruvate)...
October 2016: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
Mahmut Kalem, Ercan Şahin, Murat Songür, Sinan Zehir, Mehmet Armangil, Mehmet A Demirtaş
OBJECTIVE: This experimental study investigates the effectiveness of expanded polytetrafluoroethylene (Dualmesh®, Gore Medical, Flagstaff, AZ, USA), sodium hyaluronate-carboxymethyl cellulose (Seprafilm®, Genzyme, Cambridge, MA, USA), and polysiloxane (silicone) as anti-adhesive barriers for inhibition of fibrosis in the subacromial area following rotator cuff repair. METHODS: Rabbit rotator cuff tenotomy and repair was conducted on 24 rabbits in 4 groups: control (Group A), Dualmesh® (Group B), Seprafilm® (Group C), and silicone (Group D)...
2016: Acta Orthopaedica et Traumatologica Turcica
A Hinoki, A Saito, M Kinoshita, J Yamamoto, D Saitoh, S Takeoka
BACKGROUND: Ultrathin films (nanosheets) adhere tightly to organ surfaces but prevent adhesion to other organs. The antiadhesive effect of nanosheets and their effect on bacterial propagation were investigated in a murine intestinal adhesion model. METHODS: Polylactic acid nanosheets (approximately 80 nm thick) were produced. Serosal defects were created by peeling off the intestinal serosa; these were left open or covered with nanosheets or Seprafilm® and the formation of intestinal adhesions was analysed...
March 3, 2016: British Journal of Surgery
Songül Büyükkale, Necati Çıtak, Özgür İşgörücü, Adnan Sayar
INTRODUCTION: The aim of this experimental study was to investigate the anti-adhesion property of a bioabsorbable membrane following mediastinoscopy in a rat model. METHODS: The study was conducted in 20 male Sprague-Dawley rats. Mediastinoscopy was performed all of them. Rats were divided into two groups; control group (n=10); mediastinoscopy alone, study group (n=10); mediastinoscopy and sodiumhyaluronate-carboxymethlycellulose film (Seprafilm®; Genzyme Corporation, Cambridge, Mass...
2015: International Journal of Clinical and Experimental Medicine
Hiroyuki Nakagawa, Yoko Matsumoto, Yu Matsumoto, Yoshihiro Miwa, Yukio Nagasaki
Postsurgical tissue adhesion formation caused by inflammation and oxidative stress is one of the serious issues because it induces severe clinical disorders. In this study, we designed redox injectable gel (RIG) which covalently possesses nitroxide radicals as a reactive oxygen species (ROS) scavenger for high performance anti-adhesion agent. The redox flower micelles exhibiting gelation under physiological conditions were prepared by a polyion complex (PIC) between polyamine-PEG-polyamine triblock copolymer possessing nitroxide radicals as a side chain of polyamine segments and poly(acrylic acid)...
November 2015: Biomaterials
Chih-Hao Chen, Shih-Hsien Chen, K T Shalumon, Jyh-Ping Chen
Postoperative adhesion formation is the major complication that could occur after acute tendon surgery. The application of an anti-adhesive membrane at the post-surgical site is deemed as a potential way to solve this problem by preventing adhesive fibrotic tissue development. In this study, we fabricated electrospun composite poly(ethylene glycol) (PEG)/poly(caprolactone) (PCL) nanofibrous membrane (NFM) to prevent peritendinous adhesions, which could act as a barrier between the tendon and surrounding tissues, without interrupting mass transfer and normal tendon gliding...
September 1, 2015: Colloids and Surfaces. B, Biointerfaces
Gaity Ahmad, Helena O'Flynn, Akshay Hindocha, Andrew Watson
BACKGROUND: Pelvic adhesions can form as a result of inflammation, endometriosis or surgical trauma. During pelvic surgery, strategies to reduce pelvic adhesion formation include placing barrier agents such as oxidised regenerated cellulose, polytetrafluoroethylene or fibrin sheets between the pelvic structures. OBJECTIVES: To evaluate the effects of barrier agents used during pelvic surgery on rates of pain, live birth and postoperative adhesions in women of reproductive age...
2015: Cochrane Database of Systematic Reviews
Bruno Lefort, Jean-Marc El Arid, Anne-Lorraine Bouquiaux, Nathalie Soulé, Julie Chantreuil, Elsa Tavernier, Alain Chantepie, Paul Neville
BACKGROUND: Morbidity and mortality are higher for cardiac reoperations than first operation due to the presence of post-operative adhesions. We retrospectively evaluated the efficacy of the bioresorbable membrane Seprafilm to prevent pericardial adhesions after cardiac surgery in a paediatric congenital heart disease population. METHODS: Seventy-one children undergoing reoperations with sternotomy redo and cardiopulmonary bypass for congenital malformations were included...
2015: Journal of Cardiothoracic Surgery
Peyman Dinarvand, Seyed Mahdi Hassanian, Hartmut Weiler, Alireza R Rezaie
Postsurgical peritoneal adhesion bands are the most important causes of intestinal obstruction, pelvic pain, and female infertility. In this study, we used a mouse model of adhesion and compared the protective effect of activated protein C (APC) to that of the Food and Drug Administration-approved antiadhesion agent, sodium hyaluronate/carboxymethylcellulose (Seprafilm) by intraperitoneal administration of either APC or Seprafilm to experimental animals. Pathological adhesion bands were graded on day 7, and peritoneal fluid concentrations of tissue plasminogen activator (tPA), d-dimer, thrombin-antithrombin complex, and cytokines (IL-1β, IL-6, interferon-γ, tumor necrosis factor-α, transforming growth factor-β1) were evaluated...
February 19, 2015: Blood
Shyh Ming Kuo, Shwu Jen Chang, Hung-Yi Wang, Shu Ching Tang, Shan-Wei Yang
After tendon-repair surgery, adhesion between the surgical tendon and the synovial sheath is often presented resulting in poor functional repair of the tendon. This may be prevented using a commercially available mechanical barrier implant, Seprafilm, which is composed of hyaluronan (HA) and carboxymethyl cellulose hydrogels. In a rat model, prepared membranes of various compositions of gellan gum (GG), xanthan gum (XG) and HA as well as Seprafilm were wrapped around repaired tendons and the adhesion of the tendons was examined grossly and histologically after 3 weeks of healing...
December 19, 2014: Carbohydrate Polymers
E Kıyak Caglayan, K Caglayan, N Erdogan, H Cinar, B Güngör
OBJECTIVE: To compare the effectiveness of ethyl pyruvate (EP) with that of hyaluronic acid+carboxymethyl cellulose (Seprafilm) for the prevention of intraperitoneal adhesions. Seprafilm has been shown to be effective in many experimental and clinical studies. STUDY DESIGN: Thirty rats were divided into three groups at random, and uterine horn abrasion was performed by laparotomy. One group received no treatment (control group), one group received a single intraperitoneal dose of EP 50mg/kg (EP group), and a 2×1-cm patch of Seprafilm was applied in the third group (Seprafilm group)...
October 2014: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Stanislaw P Stawicki, John M Green, Niels D Martin, Raymond H Green, James Cipolla, Mark J Seamon, Daniel S Eiferman, David C Evans, Joshua P Hazelton, Charles H Cook, Steven M Steinberg
INTRODUCTION: The open abdominal (OA) approach is a management strategy used in the most severely injured trauma patients. In addition to the morbidity and mortality, a major challenge is the gradual development of dense adhesions that make reoperations progressively more difficult. This randomized, prospective, proof-of-concept study was conducted to determine the effect of carboxymethylcellulose sodium hyaluronate adhesion barrier (CMHAB; Seprafilm, Genzyme Biosurgery, Bridgewater, NJ) on abdominal adhesions and wound characteristics in trauma open abdomens...
August 2014: Surgery
Ahmet Karatas, Tulay Ozlu, Gulzade Ozyalvacli, Mehmet Tosun, Ayhan Cetinkaya, Melahat Emine Donmez, Arzu Turker, Husna Bayrakdar
OBJECTIVE: To evaluate intraperitoneal administration of Nigella sativa (NS) to prevent postoperative intraperitoneal adhesion (PPA) after surgical manipulation of rat uterine horn. MATERIALS AND METHODS: Two forms of NS were used in the study (Volatile oil (NSVO) and the ethanolic extract (NSEE)). A total of 50 rats were randomly assigned to the sham group (n = 10), control group (n = 10), NSVO group (n = 10), NSEE group (n = 10), and the Seprafilm group(n = 10)...
December 2014: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
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