Ida Gregersen, Xiang Y Kong, Sander Kooijman, Håvard Foyn, Helene Grannes, Maria B Olsen, Anna M Lone, Kuan Yang, Ana Quiles-Jiménez, Marianne Tran, Jonas Øgaard, Filip M Segers, Azita Rashidi, Ellen Lund Sagen, Knut H Lauritzen, Amanda C M Pronk, Jan Freark de Boer, Kirsten B Holven, Espen Melum, Pål Aukrust, Kjetil Taskén, Sverre Holm, Patrick C N Rensen, Tuva B Dahl, Bente Halvorsen
Obesity is a complex multicausal disease that can cause morbidity and mortality, and there is need for improved knowledge on the underlying mechanisms. Using a mouse model of increased T cell responsiveness, we show that development of obesity can be driven by immune cells. This was confirmed with bone marrow transplantation and adoptive T cell transfer to several recipient mouse models. Single-cell RNA sequencing and CyTOF analysis showed that the mice display altered composition of circulating T cells and increased T cell activation in visceral adipose tissue, suggesting activated T cells as critical players in the increased fat mass...
April 19, 2024: IScience