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cardiac denervation post ablation

Naoko Yamaguchi, Kentaro Yamakawa, Pradeep S Rajendran, Tatsuo Takamiya, Marmar Vaseghi
BACKGROUND: Neuraxial modulation with cardiac sympathetic denervation (CSD) can potentially reduce burden of ventricular tachyarrhythmias (VT). However, despite catheter ablation and CSD, VT can recur in patients with cardiomyopathy and the role of vagal nerve stimulation (VNS) in this setting is unclear. OBJECTIVE: The purpose of this study was to evaluate the electrophysiological effects of VNS after CSD in normal and infarcted hearts. METHODS: In 10 normal and 6 infarcted pigs, electrophysiological and hemodynamic parameters were evaluated before and during intermittent VNS pre-CSD (bilateral stellectomy and T2-T4 thoracic ganglia removal) as well as post-CSD...
March 9, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Erin J Howden, Cara East, Justin S Lawley, Abigail S L Stickford, Myrthe Verhees, Qi Fu, Benjamin D Levine
BACKGROUND: Whether renal denervation (RDN) in patients with resistant hypertension normalizes blood pressure (BP) regulation in response to routine cardiovascular stimuli such as upright posture is unknown. We conducted an integrative study of BP regulation in patients with resistant hypertension who had received RDN to characterize autonomic circulatory control. METHODS: Twelve patients (60 ± 9 [SD] years, n = 10 males) who participated in the Symplicity HTN-3 trial were studied and compared to 2 age-matched normotensive (Norm) and hypertensive (unmedicated, HTN) control groups...
June 1, 2017: American Journal of Hypertension
Y Huang, D-N Wang, P Liu, Y Song, H-M Cui, J-Y Zhang, J Blackwell, D-N Liao
OBJECTIVE: To observe the effects of local radiofrequency denervation on ventricular effective refractory periods, electrical alternans and ventricular arrhythmia susceptibility post myocardial infarction. MATERIALS AND METHODS: Thirty-four mongrel dogs were randomly divided into the normal heart group (n = 16, 8 in sham and 8 in local sympathetic denervation - LSD) and the acute myocardial ischemia (AMI) group (n = 18, 9 in control and 9 in LSD). The left cardiac sympathetic nerve was denervated with irrigated catheter radiofrequency ablation...
June 2016: European Review for Medical and Pharmacological Sciences
Márcio Galindo Kiuchi, Gustavo Ramalho E Silva, Luis Marcelo Rodrigues Paz, Shaojie Chen, Gladyston Luiz Lima Souto
BACKGROUND OR PURPOSE: Polymorphic premature ventricular complexes (PVCs) are very common, appearing most frequently in patients with hypertension, obesity, sleep apnea, and structural heart disease. Sympathetic hyperactivity plays a critical role in the development, maintenance, and aggravation of ventricular arrhythmias. Recently, the relevance of sympathetic activation in patients with ventricular arrhythmias was reported, and this finding suggested a potential role for catheter-based renal sympathetic denervation in reducing the arrhythmic burden...
November 2016: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Francesca Cagnoni, Maurizio Destro, Erika Bontempelli, Giovanni Locatelli, Dagmara Hering, Markus P Schlaich
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. Overactivation of the sympathetic nervous system (SNS) plays an important role in the pathogenesis of comorbidities related to AF such as hypertension, congestive heart failure, obesity, insulin resistance, and obstructive sleep apnea. Methods that reduce sympathetic drive, such as centrally acting sympatho-inhibitory agents, have been shown to reduce the incidence of spontaneous or induced atrial arrhythmias, suggesting that neuromodulation may be helpful in controlling AF...
February 2016: Current Hypertension Reports
Yun Xie, Qiliang Liu, Youlong Xu, Junqing Gao, Pengyong Yan, Wenquan Zhang, Jianguang Sun, Mingyu Wang, Huigen Jin, Jinfa Jiang, Zongjun Liu
OBJECTIVE: This study investigated the effect of catheter-based renal sympathetic denervation (RDN) in pigs with rapid pacing induced heart failure. METHODS: Heart failure was induced by rapid right ventricular pacing in 12 pigs and pigs were randomly divided into RDN group (n = 6): pacing+RDN at 7 days post pacing; control group (n = 6): pacing only. Echocardiography examination (LVEF, LVEDD and LVESD) was performed before pacing and at 1 and 2 weeks post pacing...
January 2014: Zhonghua Xin Xue Guan Bing za Zhi
L R A Olde Nordkamp, A H G Driessen, A Odero, N A Blom, D R Koolbergen, P J Schwartz, A A M Wilde
INTRODUCTION: Treating therapy-resistant patients with inherited arrhythmia syndromes can be difficult and left cardiac sympathetic denervation (LCSD) might be a viable alternative treatment option. We provide an overview of the indications and outcomes of LCSD in patients with inherited arrhythmia syndromes in the only tertiary referral centre in the Netherlands where LCSD is conducted in these patients. METHODS: This was a retrospective study, including all patients with inherited arrhythmia syndromes who underwent LCSD in our institution between 2005 and 2013...
April 2014: Netherlands Heart Journal
Rodrigo Del Rio, Noah J Marcus, Harold D Schultz
OBJECTIVES: This study sought to investigate whether selective ablation of the carotid body (CB) chemoreceptors improves cardiorespiratory control and survival during heart failure. BACKGROUND: Chronic heart failure (CHF) is a recognized health problem worldwide, and novel treatments are needed to better improve life quality and decrease mortality. Enhanced carotid chemoreflex drive from the CB is thought to contribute significantly to autonomic dysfunction, abnormal breathing patterns, and increased mortality in heart failure...
December 24, 2013: Journal of the American College of Cardiology
Demosthenes G Katritsis, Evgeny Pokushalov, Alexander Romanov, Eleftherios Giazitzoglou, George C M Siontis, Sunny S Po, A John Camm, John P A Ioannidis
OBJECTIVES: The aim of this study was to investigate whether the combination of conventional pulmonary vein isolation (PVI) by circumferential antral ablation with ganglionated plexi (GP) modification in a single ablation procedure, yields higher success rates than PVI or GP ablation alone, in patients with paroxysmal atrial fibrillation (PAF). BACKGROUND: Conventional PVI transects the major left atrial GP, and it is possible that autonomic denervation by inadvertent GP ablation plays a central role in the efficacy of PVI...
December 17, 2013: Journal of the American College of Cardiology
Cécile Otten, Salim Abdelilah-Seyfried
Various experimental approaches have been used in mouse to induce muscle injury with the aim to study muscle regeneration, including myotoxin injections (bupivacaine, cardiotoxin or notexin), muscle transplantations (denervation-devascularization induced regeneration), intensive exercise, but also murine muscular dystrophy models such as the mdx mouse (for a review of these approaches see). In zebrafish, genetic approaches include mutants that exhibit muscular dystrophy phenotypes (such as runzel or sapje) and antisense oligonucleotide morpholinos that block the expression of dystrophy-associated genes...
2013: Journal of Visualized Experiments: JoVE
Cleo A C Leite, Edwin W Taylor, Tobias Wang, Augusto S Abe, Denis O V de Andrade
The morphologically undivided ventricle of the heart in non-crocodilian reptiles permits the mixing of oxygen-rich blood returning from the lungs and oxygen-poor blood from the systemic circulation. A possible functional significance for this intra-cardiac shunt has been debated for almost a century. Unilateral left vagotomy rendered the single effective pulmonary artery of the South American rattlesnake, Crotalus durissus, unable to adjust the magnitude of blood flow to the lung. The higher constant perfusion of the lung circulation and the incapability of adjusting the right-left shunt in left-denervated snakes persisted over time, providing a unique model for investigation of the long-term consequences of cardiac shunting in a squamate...
May 15, 2013: Journal of Experimental Biology
Humera Ahmed, Petr Neuzil, Jan Skoda, Jan Petru, Lucie Sediva, Marcela Schejbalova, Vivek Y Reddy
OBJECTIVES: This study sought to assess whether renal sympathetic denervation (RSDN) can be achieved using an off-the-shelf saline-irrigated radiofrequency ablation (RFA) catheter typically employed for cardiac tissue ablation. BACKGROUND: RSDN using a specialized solid-tip RFA catheter has recently been demonstrated to safely reduce systemic blood pressure in patients with refractory hypertension. For cardiac tissue ablation, RFA technology has evolved from nonirrigated to saline-irrigated ablation electrodes to improve both safety and effectiveness...
July 2012: JACC. Cardiovascular Interventions
Mira A Coleman, J Martijn Bos, Jonathan N Johnson, Heidi J Owen, Claude Deschamps, Christopher Moir, Michael J Ackerman
BACKGROUND: Treatment options for patients with recurrent ventricular arrhythmias refractory to pharmacotherapy and ablation are minimal. Although left cardiac sympathetic denervation (LCSD) is well established in long-QT syndrome, its role in non-long-QT syndrome arrhythmogenic channelopathies and cardiomyopathies is less clear. Here, we report our single-center experience in performing LCSD in this setting. METHODS AND RESULTS: In this institutional review board-approved study, we retrospectively reviewed the electronic medical records of all patients (N=91) who had videoscopic LCSD at our institution from 2005 to 2011...
August 1, 2012: Circulation. Arrhythmia and Electrophysiology
Jose Carlos M Pachon, Enrique Indalecio M Pachon, Maria Zelia Cunha Pachon, Tasso Julio Lobo, Juan Carlos M Pachon, Tomas Guilhermo P Santillana
AIMS: Neurally meditated reflex or neurocardiogenic or vasovagal syncope (NMS) is usually mediated by a massive vagal reflex. This study reports the long-term outcome of NMS therapy based on endocardial radiofrequency (RF) catheter ablation of the cardiac vagal nervous system aiming permanent attenuation or elimination of the cardioinhibitory reflex (cardioneuroablation). METHODS AND RESULTS: A total of 43 patients (18F/25M, 32.9 ± 15 years) without apparent cardiopathy (left ventricular ejection fraction=68...
September 2011: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Krishnakumar Nair, Menashe Waxman, Talha Farid, Kumaraswamy Nanthakumar
Radiofrequency ablation of post-transplant flutter in a centrally denervated donor atrium at a site remote from the AV node resulted in transient worsening of AV nodal conduction, with absent central vagal reinnervation. This could be an electrophysiological marker of intact innervation to the donor AV node from the intrinsic cardiac neuronal plexus, not demonstrated in human hearts earlier.
February 2010: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Mehdi Razavi, Jie Cheng, Abdi Rasekh, Donghui Yang, Scott Delapasse, Tomohiko Ai, Thomas Meade, Alan Donsky, Mary J Goodman, Ali Massumi
BACKGROUND: Studies indicate that success of radiofrequency (RF) ablation of atrial fibrillation (AF) may be in part due to vagal denervation. RFAof supraventricular tachycardia (SVT) has been associated with vagal denervation. The effects of slow pathway (SP) ablation on AF inducibility have not been studied. OBJECTIVE: To test the hypothesis that SP ablation renders AF less inducible. METHODS: Consecutive patients referred for SVT were studied...
November 2006: Pacing and Clinical Electrophysiology: PACE
N Zhao, M Khan, S Ingenito, A L Sica, N Gootman, P M Gootman
Using a conscious swine model, we studied the effects of different patterns of cardiac autonomic denervation on alterations of R-R and Q T intervals for 8 postnatal weeks. Newborn pigs were assigned randomly to four different groups: sham-operated controls (C), stellate ganglion ablation (SGX), either left (LSGX) or right (RSGX), and the right cardiac vagus nerve (RCVX) transection. The ECGs were recorded by telemetry while animals rested quietly or were judged behaviorally to be asleep. Analyses of the ECG included measurements of R-R and Q-T intervals, as well as corrected Q-T intervals (QTc)...
May 14, 2001: Autonomic Neuroscience: Basic & Clinical
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