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https://www.readbyqxmd.com/read/28532092/cytocompatibility-studies-of-titania-doped-calcium-borosilicate-bioactive-glasses-in-vitro
#1
Rajkumar Samudrala, Abdul Azeem P, Vasudevarao Penugurti, Bramanandam Manavathi
The present study aims to elucidate the applications of Titania (TiO2) doped calcium borosilicate glass as a biocompatible material in regenerative orthopedic applications. In this context, we have examined the bioactivity of various concentrations of TiO2 doped glasses with the help of simulated body fluid (SBF). Cytocompatibility, cell proliferation, and protein expression studies revealed the potential candidature of TiO2 doped glasses on osteoblast cell lines (MG-63). We hypothesized that TiO2 doped calcium borosilicate glasses are most cytocompatible material for bone implants...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28523072/delayed-endothelial-progenitor-cell-therapy-promotes-bone-defect-repair-in-a-clinically-relevant-rat-model
#2
Brent D Bates, Charles Godbout, David J Ramnaraign, Emil H Schemitsch, Aaron Nauth
The repair of segmental bone defects remains a significant challenge for orthopaedic surgeons. Endothelial progenitor cells (EPCs) have successfully promoted the repair of acute defects in animal models; however, the ability of EPCs to induce the repair of chronic nonhealing defects, such as those often encountered clinically, has not been investigated. Therefore, the purpose of this study was to investigate the ability of EPCs delivered in delayed fashion to induce the repair of nonhealing defects in a clinically relevant model...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28521380/-clinical-practical-examination-in-orthopaedic-teaching-who-is-the-ideal-examiner
#3
Peter Melcher, Andreas Roth, Mohamed Ghanem, Daisy Rotzoll
Background Medical curricula require an increasing amount of integrated clinical practical skills education. German medical faculties are increasingly implementing the OSCE (objective structured clinical examination) to test students' practical as well as communication skills. Teaching and assessment tools for practical skills include simulators and simulated patient scenarios, where peer-assisted teaching (PAT) is applied. Trained student tutors support this process. This study examines for the first time the use of PAT student tutors as examiners in an orthopaedic OSCE unit and the existence of possible differences in rating between faculty and PAT student tutors...
May 18, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28507421/orthopaedic-tumors-what-problems-are-we-solving-and-are-universities-and-major-medical-centers-doing-enough
#4
Mohamed Mediouni, Daniel R Schlatterer
Little has been published about the complexity of orthopaedic tumors compared to others tumors. The current study in the literature treated this problem in terms of classification, surgical intervention and impact on the patient. In this article, factors risks of tumors will be we identified. A strategy based on three dimensional simulations will be explained in order to improve the clinical trials.
June 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/28504931/robust-real-time-musculoskeletal-modeling-driven-by-electromyograms
#5
Guillaume Durandau, Dario Farina, Massimo Sartori
OBJECTIVE: Current clinical biomechanics involves lengthy data acquisition and time-consuming offline analyses and current biomechanical models cannot be used for real-time control in man-machine interfaces. We developed a method that enables online analysis of neuromusculoskeletal function in vivo in the intact human. METHODS: We used electromyography (EMG)-driven musculoskeletal modeling to simulate all transformations from muscle excitation onset (EMGs) to mechanical moment production around multiple lower-limb degrees of freedom (DOFs)...
May 12, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28503805/development-of-a-siyalon-glaze-for-improved-osteoconductivity-of-implantable-medical-devices
#6
Ryan M Bock, Elia Marin, Alfredo Rondinella, Francesco Boschetto, Tetsuya Adachi, Bryan J McEntire, B Sonny Bal, Giuseppe Pezzotti
The application of bioactive coatings onto orthopaedic appliances is commonly performed to compensate for the otherwise bioinert nature of medical devices and to improve their osseointegration. Calcium phosphates, hydroxyapatite (HAp), and bioglasses are commercially available for this purpose. Until recently, few other inorganic compounds have been identified with similar biofunctionality. However, silicon nitride (Si3 N4 ) has emerged as a new orthopaedic material whose unique surface chemistry also enhances osteoconductivity...
May 15, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28502388/the-grapefruit-an-alternative-arthroscopic-tool-skill-platform
#7
David A Molho, Stephen M Sylvia, Daniel L Schwartz, Sara L Merwin, I Martin Levy
PURPOSE: To establish the construct validity of an arthroscopic training model that teaches arthroscopic tool skills including triangulation, grasping, precision biting, implant delivery and ambidexterity and uses a whole grapefruit for its training platform. METHODS: For the grapefruit training model (GTM), an arthroscope and arthroscopic instruments were introduced through portals cut in the grapefruit skin of a whole prepared grapefruit. After institutional review board approval, participants performed a set of tasks inside the grapefruit...
May 11, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28497097/a-randomized-controlled-pilot-study-of-educational-techniques-in-teaching-basic-arthroscopic-skills-in-a-low-income-country
#8
Abhiram R Bhashyam, Catherine Logan, Heather J Roberts, Rameez A Qudsi, Jacky Fils, George S M Dyer
BACKGROUND: Little is known about how to introduce complex technologies like arthroscopy into low-income countries. Thus, we compared low- versus high-resource intensive methods of teaching basic arthroscopic skills in a randomized controlled trial in Haiti. METHODS: Forty-eight Haitian orthopaedic surgeons and residents attending an orthopaedic conference in Haiti were block randomized to receive instruction through a composite video (Control) or a composite video plus hands-on teaching with an expert visiting surgeon (Intervention)...
March 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/28481956/tibial-revision-knee-arthroplasty-with-metaphyseal-sleeves-the-effect-of-stems-on-implant-fixation-and-bone-flexibility
#9
Jan Nadorf, Stefan Kinkel, Simone Gantz, Eike Jakubowitz, J Philippe Kretzer
INTRODUCTION: Revision total knee arthoplasty often requires modular implants to treat bone defects of varying severity. In some cases, it may not be clear which module size and implant combination (e.g. sleeve and stem) should be chosen for a specific defect. When balancing implant stability and osseointegration against stress-shielding, it is important to choose an appropriate implant combination in order to match the given level of bone loss. Therefore, the necessity of stems in less extensive tibial defects and the advantage of different stems (lengths and stiffnesses) in combination with large metaphyseal sleeves on implant fixation and bone flexibility using a modular tibial revision knee system, were analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28475021/individualized-3d-printed-model-assisted-posterior-screw-fixation-for-the-treatment-of-craniovertebral-junction-abnormality-a-retrospective-study
#10
Fangyou Gao, Qu Wang, Chuangxi Liu, Bing Xiong, Tao Luo
OBJECTIVE This study was undertaken to evaluate the feasibility and efficacy of individualized 3D printed model-assisted posterior internal fixation in treating craniovertebral junction (CVJ) abnormalities. METHODS Forty-four patients (19 males and 25 females; mean age 36.5 ± 9.2 years, range 11-62 years; symptom duration 1 month-15 years) with a CVJ abnormality who were admitted to the authors' institution between April 2010 and April 2015 were retrospectively studied. The individualized 3D printed model of the CVJ was produced based on the individual CT data by use of 3D printing technology...
May 5, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28474057/-biomechanical-effect-of-2-anchorages-on-maxillary-protraction-with-cleft-lip-and-palate-a-finite-element-analysis
#11
Han Han, Ya-Fen Xu, Yu-Feng Duan, Yong-Hua Lei
PURPOSE: To establish cranio-maxillary complex finite element models (FEMs) in cleft lip and palate (CLP) patients with miniplate and tooth-borne anchorage, and to investigate the biomechanical effects on maxillary protraction. METHODS: The protracting process was simulated on FEMs established from a male patient's cone beam CT (CBCT) data to analyze the displacement and stress from different appliances. RESULTS: Four FEMs of unilateral cleft lip and palate (UCLP) or bilateral cleft lip and palate (BCLP) patients' cranio-maxillary complex with MA and TA were established...
February 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/28473955/orthopaedic-education-in-the-era-of-surgical-simulation-still-at-the-crawling-stage
#12
EDITORIAL
Kivanc Atesok, Peter MacDonald, Jeff Leiter, James Dubberley, Richard Satava, Ann VanHeest, Shepard Hurwitz, J Lawrence Marsh
Surgical skills education is in the process of a crucial transformation from a master-apprenticeship model to simulation-based training. Orthopaedic surgery is one of the surgical specialties where simulation-based skills training needs to be integrated into the curriculum efficiently and urgently. The reason for this strong and pressing need is that orthopaedic surgery covers broad human anatomy and pathologies and requires learning enormously diverse surgical procedures including basic and advanced skills...
April 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28473698/implantable-strain-sensor-to-monitor-fracture-healing-with-standard-radiography
#13
Hunter Pelham, Donald Benza, Paul W Millhouse, Nathan Carrington, Md Arifuzzaman, Caleb J Behrend, Jeffrey N Anker, John D DesJardins
Current orthopaedic clinical methods do not provide an objective measure of fracture healing or weight bearing for lower extremity fractures. The following report describes a novel approach involving in-situ strain sensors to objectively measure fracture healing. The sensor uses a cantilevered indicator pin that responds to plate bending and an internal scale to demonstrate changes in the pin position on plain film radiographs. The long lever arm amplifies pin movement compared to interfragmentary motion, and the scale enables more accurate measurement of position changes...
May 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28457266/effects-of-monocortical-and-bicortical-mini-implant-anchorage-on-bone-borne-palatal-expansion-using-finite-element-analysis
#14
Robert J Lee, Won Moon, Christine Hong
INTRODUCTION: Bone-borne palatal expansion relies on mini-implant stability for successful orthopedic expansion. The large magnitude of applied force experienced by mini-implants during bone-borne expansion may lead to high failure rates. Use of bicortical mini-implant anchorage rather than monocortical anchorage may improve mini-implant stability. The aims of this study were to analyze and compare the effects of bicortical and monocortical anchorages on stress distribution and displacement during bone-borne palatal expansion using finite element analysis...
May 2017: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/28415419/lsp-mao-composite-bio-coating-on-az80-magnesium-alloy-for-biomedical-application
#15
Ying Xiong, Qiang Hu, Renguo Song, Xiaxia Hu
A composite bio-coating was fabricated on AZ80 magnesium (Mg) alloy by using micro-arc oxidation (MAO) under the pretreatment of laser shock peening (LSP) in order to improve the bio-corrosion resistance and the mechanical integrity. LSP treatment could induce grain refinement and compressive residual stress field on the surface of material. MAO bio-coating was grown in alkaline electrolyte with hydroxyapatite (HA, Ca10(PO4)6(OH)2) to improve the biological properties of the material. The microstructure, element and phase composition for untreated based material (BM) and treated samples (LSP layer, MAO bio-coating and LSP/MAO composite bio-coating) were investigated by transmission electron microscopy (TEM), scanning electron microscope (SEM), energy dispersion spectroscopy (EDS) and X-ray diffraction (XRD)...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28410527/mechanisms-of-the-photochemical-release-of-phosphate-from-resuspended-sediments-under-solar-irradiation
#16
Xiaolu Li, Yiyong Zhou, Guanglong Liu, Hongjun Lei, Duanwei Zhu
In previous studies, resuspended sediments that were exposed to simulated solar irradiation could release dissolved phosphate (PO4(3-)). However, the mechanisms of phosphate release remain unclear. In this research, a battery of experiments was performed to reveal the mechanisms of the photochemical release of phosphate from resuspended sediments of a shallow eutrophic lake under solar irradiation. The results show that the PO4(3-) released in resuspended sediments was significantly higher than that in the dark control or in water alone after treatment with solar irradiation for 6h...
October 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28389485/operational-strategies-to-manage-non-elective-orthopaedic-surgical-flows-a-simulation-modelling-study
#17
Marie Persson, Helena Hvitfeldt-Forsberg, Maria Unbeck, Olof Gustaf Sköldenberg, Andreas Stark, Paula Kelly-Pettersson, Pamela Mazzocato
OBJECTIVES: To explore the value of simulation modelling in evaluating the effects of strategies to plan and schedule operating room (OR) resources aimed at reducing time to surgery for non-elective orthopaedic inpatients at a Swedish hospital. METHODS: We applied discrete-event simulation modelling. The model was populated with real world data from a university hospital with a strong focus on reducing waiting time to surgery for patients with hip fracture. The system modelled concerned two patient groups that share the same OR resources: hip-fracture and other non-elective orthopaedic patients in need of surgical treatment...
April 7, 2017: BMJ Open
https://www.readbyqxmd.com/read/28376059/skeletal-assessment-with-finite-element-analysis-relevance-pitfalls-and-interpretation
#18
Graeme Michael Campbell, Claus-C Glüer
PURPOSE OF REVIEW: Finite element models simulate the mechanical response of bone under load, enabling noninvasive assessment of strength. Models generated from quantitative computed tomography (QCT) incorporate the geometry and spatial distribution of bone mineral density (BMD) to simulate physiological and traumatic loads as well as orthopaedic implant behaviour. The present review discusses the current strengths and weakness of finite element models for application to skeletal biomechanics...
April 3, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28374679/in-vitro-study-of-electrodeposited-fluoridated-hydroxyapatite-coating-on-g-ii-titanium-with-a-nanostructured-tio2-interlayer
#19
Jin-Shyong Lin, Tzung-Bau Tsai, Wen-Ching Say, Chun Chiu, Shih-Hsun Chen
Titanium and its alloys have been widely used as orthopedic and dental implants for several decades due to their superior mechanical properties, corrosion resistance and biocompatibility. Recently, many researches revealed that the hydroxyapatite coatings on biomedical materials can further improve their biocompatibility and bioactivity. However, hydroxyapatite coatings are easily decomposed, weakening the bonding between implants and bone tissues and resulting in a high dissolution rate in the biological environment...
April 4, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28374350/teaching-the-basics-development-and-validation-of-a-distal-radius-reduction-and-casting-model
#20
Mark A Seeley, Peter D Fabricant, J Todd R Lawrence
BACKGROUND: Approximately one-third of reduced pediatric distal radius fractures redisplace, resulting in further treatment. Two major modifiable risk factors for loss of reduction are reduction adequacy and cast quality. Closed reduction and immobilization of distal radius fractures is an Accreditation Council for Graduate Medical Education residency milestone. Teaching and assessing competency could be improved with a life-like simulation training tool. QUESTIONS/PURPOSES: Our goal was to develop and validate a realistic distal radius fracture reduction and casting simulator as determined by (1) a questionnaire regarding the "realism" of the model and (2) the quantitative assessments of reduction time, residual angulation, and displacement...
April 3, 2017: Clinical Orthopaedics and related Research
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