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Simulation AND Virtual

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https://www.readbyqxmd.com/read/28098503/relationship-between-perceived-competence-and-performance-during-real-and-virtual-motor-tasks-by-children-with-developmental-coordination-disorder
#1
Batya Engel-Yeger, Rotem Sido, Aviva Mimouni-Bloch, Patrice L Weiss
PURPOSE: (i) To compare children with DCD and typically developing participants via standard motor assessments, two interactive virtual games, measures of physical, social and cognitive self-competence and feedback while playing the virtual games and (ii) To examine the contribution of age and each motor assessment to predict self-competence. METHODS: Participants were 25 boys with DCD and 25 typically developing boys, aged 5-9 years. They completed the M-ABC-2, the Pictorial Scale of Perceived Competence, the 6-Minute Walk Test, and then played the two Kinect games and completed the Short Feedback Questionnaire for Children...
January 18, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/28097218/energy-penetration-into-arrays-of-aligned-nanowires-irradiated-with-relativistic-intensities-scaling-to-terabar-pressures
#2
Clayton Bargsten, Reed Hollinger, Maria Gabriela Capeluto, Vural Kaymak, Alexander Pukhov, Shoujun Wang, Alex Rockwood, Yong Wang, David Keiss, Riccardo Tommasini, Richard London, Jaebum Park, Michel Busquet, Marcel Klapisch, Vyacheslav N Shlyaptsev, Jorge J Rocca
Ultrahigh-energy density (UHED) matter, characterized by energy densities >1 × 10(8) J cm(-3) and pressures greater than a gigabar, is encountered in the center of stars and inertial confinement fusion capsules driven by the world's largest lasers. Similar conditions can be obtained with compact, ultrahigh contrast, femtosecond lasers focused to relativistic intensities onto targets composed of aligned nanowire arrays. We report the measurement of the key physical process in determining the energy density deposited in high-aspect-ratio nanowire array plasmas: the energy penetration...
January 2017: Science Advances
https://www.readbyqxmd.com/read/28097210/preclinical-positron-emission-tomography-scanner-based-on-a-monolithic-annulus-of-scintillator-initial-design-study
#3
Alexander V Stolin, Peter F Martone, Gangadhar Jaliparthi, Raymond R Raylman
Positron emission tomography (PET) scanners designed for imaging of small animals have transformed translational research by reducing the necessity to invasively monitor physiology and disease progression. Virtually all of these scanners are based on the use of pixelated detector modules arranged in rings. This design, while generally successful, has some limitations. Specifically, use of discrete detector modules to construct PET scanners reduces detection sensitivity and can introduce artifacts in reconstructed images, requiring the use of correction methods...
January 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28095849/simulated-case-management-of-home-telemonitoring-to-assess-the-impact-of-different-alert-algorithms-on-work-load-and-clinical-decisions
#4
Illapha Cuba Gyllensten, Amanda Crundall-Goode, Ronald M Aarts, Kevin M Goode
BACKGROUND: Home telemonitoring (HTM) of chronic heart failure (HF) promises to improve care by timely indications when a patient's condition is worsening. Simple rules of sudden weight change have been demonstrated to generate many alerts with poor sensitivity. Trend alert algorithms and bio-impedance (a more sensitive marker of fluid change), should produce fewer false alerts and reduce workload. However, comparisons between such approaches on the decisions made and the time spent reviewing alerts has not been studied...
January 17, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28094862/software-platform-for-simulation-of-a-prototype-proton-ct-scanner
#5
Valentina Giacometti, Vladimir A Bashkirov, Pierluigi Piersimoni, Susanna Guatelli, Tia E Plautz, Hartmut F-W Sadrozinski, Robert P Johnson, Andriy Zatserklyaniy, Thomas Tessonnier, Katia Parodi, Anatoly B Rosenfeld, Reinhard W Schulte
PURPOSE: Proton computed tomography (pCT) is a promising imaging technique to substitute or at least complement x-ray CT for more accurate proton therapy treatment planning as it allows calculating directly proton relative stopping power from proton energy loss measurements. A proton CT scanner with a silicon-based particle tracking system and a 5 stage scintillating energy detector has been completed. In parallel a modular software platform was developed to characterize the performance of the proposed pCT...
January 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/28093771/improving-prospective-memory-performance-with-future-event-simulation-in-traumatic-brain-injury-patients
#6
Giovanna Mioni, Erica Bertucci, Antonella Rosato, Gill Terrett, Peter G Rendell, Massimo Zamuner, Franca Stablum
OBJECTIVE: Previous studies have shown that traumatic brain injury (TBI) patients have difficulties with prospective memory (PM). Considering that PM is closely linked to independent living it is of primary interest to develop strategies that can improve PM performance in TBI patients. METHOD: This study employed Virtual Week task as a measure of PM, and we included future event simulation to boost PM performance. Study 1 evaluated the efficacy of the strategy and investigated possible practice effects...
January 17, 2017: British Journal of Clinical Psychology
https://www.readbyqxmd.com/read/28090509/innovations-in-surgery-simulation-a-review-of-past-current-and-future-techniques
#7
REVIEW
Ido Badash, Karen Burtt, Carlos A Solorzano, Joseph N Carey
As a result of recent work-hours limitations and concerns for patient safety, innovations in extraclinical surgical simulation have become a desired part of residency education. Current simulation models, including cadaveric, animal, bench-top, virtual reality (VR) and robotic simulators are increasingly used in surgical training programs. Advances in telesurgery, three-dimensional (3D) printing, and the incorporation of patient-specific anatomy are paving the way for simulators to become integral components of medical training in the future...
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28090102/virtual-patient-case-sharing-across-two-schools-of-pharmacy
#8
Michael A Smith, Laura A Siemianowski, Neal Benedict
Objective. To expand the use of virtual patients at 2 schools of pharmacy through virtual patient case sharing. Design. Faculty members at two schools of pharmacy collaborated to expand the use of virtual patients. Two simulation programs, vpSim and DecisionSim (Decision Simulation, LLC, Chadsford, PA), were used to create interactive patient cases for a required course and an elective course at the different schools. Each school developed cases for their own use and then shared the cases with the other school...
November 25, 2016: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28089607/estimates-of-nasal-airflow-at-the-nasal-cycle-mid-point-improve-the-correlation-between-objective-and-subjective-measures-of-nasal-patency
#9
Courtney Gaberino, John S Rhee, Guilherme J M Garcia
INTRODUCTION: The nasal cycle represents a significant challenge when comparing pre- and post-surgery objective measures of nasal airflow. METHODS: Computational fluid dynamics (CFD) simulations of nasal airflow were conducted in 12 nasal airway obstruction patients showing significant nasal cycling between pre- and post-surgery computed tomography scans. To correct for the nasal cycle, mid-cycle models were created virtually. Subjective scores of nasal patency were obtained via the Nasal Obstruction Symptom Evaluation (NOSE) and unilateral visual analog scale (VAS)...
January 9, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28089473/box-or-virtual-reality-trainer-which-tool-results-in-better-transfer-of-laparoscopic-basic-skills-a-prospective-randomized-trial
#10
Christian Brinkmann, Mathias Fritz, Ulrich Pankratius, Ralf Bahde, Philipp Neumann, Steffen Schlueter, Norbert Senninger, Emile Rijcken
OBJECTIVE: Simulation training improves laparoscopic performance. Laparoscopic basic skills can be learned in simulators as box- or virtual-reality (VR) trainers. However, there is no clear recommendation for either box or VR trainers as the most appropriate tool for the transfer of acquired laparoscopic basic skills into a surgical procedure. DESIGN: Both training tools were compared, using validated and well-established curricula in the acquirement of basic skills, in a prospective randomized trial in a 5-day structured laparoscopic training course...
January 12, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28087436/functional-connectivity-analysis-using-fnirs-in-healthy-subjects-during-prolonged-simulated-driving
#11
Liwei Xu, Bitian Wang, Gongcheng Xu, Wei Wang, Zhian Liu, Zengyong Li
Noninvasive and accurate assessment of driving fatigue in relation to brain activity during long-term driving can contribute to traffic safety and accident prevention. This study evaluated functional connectivity (FC) in relevant brain regions. Synergistic mechanisms in different brain regions were detected by a novel simulator, which combined semi-immersive virtual reality technology and functional near-infrared spectroscopy. Each subject was instructed to complete driving tasks coupled with a mental calculation task...
January 10, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28079471/pre-implant-modeling-of-depth-lead-placement-in-white-matter-for-maximizing-the-extent-of-cortical-activation-during-direct-neurostimulation-therapy
#12
Leopoldo Cendejas Zaragoza, Richard W Byrne, Marvin A Rossi
INTRODUCTION: The objective of this work was to predict preoperatively the maximum extent to which direct stimulation therapy can propagate through an epileptic circuit for stabilizing refractory focal-onset epilepsy. A pre-surgical workflow is presented which comprises a computationally intensive process for calculating the volume of cortical activation (VOCA) surrounding cylindrical depth contacts virtually placed in white matter. The process employs an activation function (AF) derived from cable modeling of an axon...
January 12, 2017: Neurological Research
https://www.readbyqxmd.com/read/28076291/individual-construction-of-freeform-fabricated-polycaprolactone-scaffolds-for-osteogenesis
#13
Lu Liu, Guixin Shi, Ying Cui, Hui Li, Zhengchao Li, Qiangcheng Zeng, Yong Guo
The construction of engineered bone mostly focuses on simulating the extracellular matrix (ECM) for proper biological activity. However, the complexity of architecture and the variability of the mechanical properties of natural bones are related to individual differences in age, nutritional state, mechanical loading and disease status. Defect substitutions should be normed with the host natural bone, balancing architectural and mechanical adaption, as well as biological activity. Using a freeform fabrication (FFF) method, we prepared polycaprolactone (PCL) scaffolds with different architectures...
January 11, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28075330/building-an-open-source-simulation-platform-of-acoustic-radiation-force-based-breast-elastography
#14
Yu Wang, Bo Peng, Jingfeng Jiang
Ultrasound-based elastography techniques including quasi-static strain elastography (SE), acoustic radiation force Impulse (ARFI) imaging, point shear wave elastography (pSWE) and supersonic shear imaging (SSI) have been used to differentiate breast tumors. The objective of this study is to extend a previously published virtual simulation platform of SE toward acoustic radiation force-based breast elastography. The proposed platform inherited four key components from the previously published virtual SE platform: an ultrasound simulator (Field II), a mesh generator (Tetgen), a finite element (FE) solver (FEBio) and a visualization and data processing package (VTK)...
January 11, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28073670/simulation-based-training-platforms-for-arthroscopy-a-randomized-comparison-of-virtual-reality-learning-to-benchtop-learning
#15
Robert M Middleton, Abtin Alvand, Patrick Garfjeld Roberts, Caroline Hargrove, Georgina Kirby, Jonathan L Rees
PURPOSE: To determine whether a virtual reality (VR) arthroscopy simulator or benchtop (BT) arthroscopy simulator showed superiority as a training tool. METHODS: Arthroscopic novices were randomized to a training program on a BT or a VR knee arthroscopy simulator. The VR simulator provided user performance feedback. Individuals performed a diagnostic arthroscopy on both simulators before and after the training program. Performance was assessed using wireless objective motion analysis and a global rating scale...
January 7, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28072524/common-hits-approach-combining-pharmacophore-modeling-and-molecular-dynamics-simulations
#16
Marcus Wieder, Arthur Garon, Ugo Perricone, Stefan Boresch, Thomas Seidel, Anna Maria Almerico, Thierry Langer
We present a new approach that incorporates flexibility based on extensive MD simulations of protein-ligand complexes into structure based pharmacophore modeling and virtual screening. The approach uses the multiple coordinate sets saved during the MD simulations and generates for each frame a pharmacophore model. Pharmacophore models with the same pharmacophore features are pooled. In this way the high number of pharmacophore models that results from the MD simulation is reduced to only a few hundred representative pharmacophore models...
January 10, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28068773/truncated-conjugate-gradient-an-optimal-strategy-for-the-analytical-evaluation-of-the-many-body-polarization-energy-and-forces-in-molecular-simulations
#17
Félix Aviat, Antoine Levitt, Benjamin Stamm, Yvon Maday, Pengyu Ren, Jay W Ponder, Louis Lagardère, Jean-Philip Piquemal
We introduce a new class of methods, denoted as Truncated Conjugate Gradient(TCG), to solve the many-body polarization energy and its associated forces in molecular simulations (i.e. molecular dynamics (MD) and Monte Carlo). The method consists in a fixed number of Conjugate Gradient (CG) iterations. TCG approaches provide a scalable solution to the polarization problem at a user-chosen cost and a corresponding optimal accuracy. The optimality of the CG-method guarantees that the number of the required matrix-vector products are reduced to a minimum compared to other iterative methods...
January 10, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28065455/spatial-curvilinear-path-following-control-of-underactuated-auv-with-multiple-uncertainties
#18
Jianming Miao, Shaoping Wang, Zhiping Zhao, Yuan Li, Mileta M Tomovic
This paper ̇α investigates the problem of spatial curvilinear path following control of underactuated autonomous underwater vehicles (AUVs) with multiple uncertainties. Firstly, in order to design the appropriate controller, path following error dynamics model is constructed in a moving Serret-Frenet frame, and the five degrees of freedom (DOFs) dynamic model with multiple uncertainties is established. Secondly, the proposed control law is separated into kinematic controller and dynamic controller via back-stepping technique...
January 5, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28064377/octopus-a-platform-for-the-virtual-high-throughput-screening-of-a-pool-of-compounds-against-a-set-of-molecular-targets
#19
Eduardo Habib Bechelane Maia, Vinícius Alves Campos, Bianca Dos Reis Santos, Marina Santos Costa, Iann Gabriel Lima, Sandro J Greco, Rosy I M A Ribeiro, Felipe M Munayer, Alisson Marques da Silva, Alex Gutterres Taranto
Octopus is an automated workflow management tool that is scalable for virtual high-throughput screening (vHTS). It integrates MOPAC2016, MGLTools, PyMOL, and AutoDock Vina. In contrast to other platforms, Octopus can perform docking simulations of an unlimited number of compounds into a set of molecular targets. After generating the ligands in a drawing package in the Protein Data Bank (PDB) format, Octopus can carry out geometry refinement using the semi-empirical method PM7 implemented in MOPAC2016. Docking simulations can be performed using AutoDock Vina and can utilize the Our Own Molecular Targets (OOMT) databank...
January 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28064083/identification-of-novel-pad4-inhibitors-based-on-a-pharmacophore-model-derived-from-transition-state-coordinates
#20
Yu Wei, Ruihua Liu, Cui Liu, Jin Jin, Dongmei Li, Jianping Lin
1.4 Protein arginine deiminases 4 (PAD4) is an attractive target for the development of novel and selective inhibitors of Rheumatoid Arthritis (RA). F-amidine is known as mechanism-based inhibitor targeting PAD4 and used as inactivators by covalently modifying the active site Cys645. To identify novel structural inhibitors of PAD4, we investigated the flexibility of protein on basis of the transition state geometry of PAD4 inhibited by F-amidine from our previous QM/MM calculation. And a pharmacophore model was generated containing four features (ADHH) using five representative structures from molecular dynamic (MD) simulation on basis of the transition state geometry of PAD4 inhibited by F-amidine...
December 19, 2016: Journal of Molecular Graphics & Modelling
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